As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryItems Standard Result Assay 99.9%min 99.9% Hangzhou Dingyan Chem is a leading manufacturer and supplier of che
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryTianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationship
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
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inquiryAtorvastatin lactone CAS:125995-03-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryProduct Name: Atorvastatin lactone Synonyms: 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide;Atorvastatin d-Lactone;Atorvastatin EP Impurity H (USP RC H)Ato
Cas:125995-03-1
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryAtorvastatin LactoneAppearance:Pls see the Details Storage:Keep away of light, hot, water, Store in dry, dark and ventilated place Package:according to customers' requirements Application:Steroids, Cosmetics Ingredients, APIs, Intermediates, OLED&Bat
Superior quality, moderate price & quick delivery. Appearance:White crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide interm
Product name: 5-(4-Fluorophenyl)-2-(1-Methylethyl)-N,4-Diphenyl-1-[2-[(2R,4R)-Tetrahydro-4-Hydroxy-6-oxo--2H-Pyran-2-yl]ethyl]-1H-Pyrrole-3-Carboxamide CAS No.:125995-03-1 Molecule Formula:C33H33FN2O4 Molecule Weight:540.62 Purity: 99.0%
Cas:125995-03-1
Min.Order:1 Kilogram
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inquiryHangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:125995-03-1
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiry1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
Cas:125995-03-1
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inquiryShanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is
Cas:125995-03-1
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Type:Other
inquiryhigh purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 96% B n/a |
1-[2-((2R,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
atorvastatin lactone
Conditions | Yield |
---|---|
With manganese(IV) oxide In acetone at 25℃; for 24h; | 95% |
With Dess-Martin periodane In dichloromethane at 20℃; for 2.5h; |
2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid
atorvastatin lactone
Conditions | Yield |
---|---|
With camphor-10-sulfonic acid In tetrahydrofuran at 20℃; for 3h; | 90% |
lipitor
atorvastatin lactone
Conditions | Yield |
---|---|
Stage #1: lipitor With hydrogenchloride In water; ethyl acetate at 4 - 20℃; Stage #2: In toluene for 2.5h; Reflux; Dean-Stark; | 88% |
With hydrogenchloride In water at 20℃; for 2h; | 55% |
Stage #1: lipitor With hydrogenchloride In dichloromethane; water Stage #2: With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Cooling with ice; | 2.78 g |
atorvastatin lactone
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water at 20℃; stereoselective reaction; | 75% |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 74% B n/a |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 70% B n/a |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 68% B n/a |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 66% B n/a |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 66% B n/a |
lipitor
A
(S)-5-(4-fluorophenyl)-2-isopropyl-1-(2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
B
atorvastatin lactone
Conditions | Yield |
---|---|
With hydrogenchloride In water for 4h; Reflux; | A 14% B 65% |
lipitor
isopropyl alcohol
A
(3R,5R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
B
atorvastatin lactone
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 54% B n/a |
atorvastatin
atorvastatin lactone
Conditions | Yield |
---|---|
In toluene at 60℃; for 40h; | 46% |
hydrogenchloride In toluene | n/a |
In toluene for 4h; Product distribution / selectivity; Heating / reflux; | |
In hexane for 6h; Heating; | 3.9 g |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 20℃; for 2.58333h; | A 44% B n/a |
1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate
atorvastatin lactone
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
(+/-)-trans-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-<2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-3-carboxamide
A
atorvastatin lactone
B
(-)-(4S)-trans-2-(4-fluorophenyl)-5-(1-methylethyl)-N,3-diphenyl-1-<(tetrahydro-4-hydroxy-2-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-4-carboxamide
Conditions | Yield |
---|---|
Yield given. Yields of byproduct given; |
methanol
atorvastatin
A
atorvastatin lactone
B
(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
Conditions | Yield |
---|---|
With phosphoric acid In acetonitrile at 80℃; for 3h; | A 15.2 mg B 6.9 mg |
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 82.5 percent / triethylamine / acetonitrile / Ambient temperature 2: triethylamine / CH2Cl2 / 1 h / 0 °C 3: NaOH / methanol; H2O / 2 h / Heating 4: 43 percent / acetic anhydride / 4 h / 90 °C 5: 1.) concd. HCl, 2.) p-TSA, H2O / 1.) ethanol, reflux, 24 h, 2.) acetone, reflux, 2 d 6: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h 7: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT 8: toluene / 6 h / Heating View Scheme |
ethyl 3-(4-cyanophenyl)propiolate
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 2: 73.9 g / methanol; tetrahydrofuran / 0 °C 3: 73 g / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 4 h / -70 °C View Scheme |
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: triethylamine / CH2Cl2 / 1 h / 0 °C 2: NaOH / methanol; H2O / 2 h / Heating 3: 43 percent / acetic anhydride / 4 h / 90 °C 4: 1.) concd. HCl, 2.) p-TSA, H2O / 1.) ethanol, reflux, 24 h, 2.) acetone, reflux, 2 d 5: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h 6: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT 7: toluene / 6 h / Heating View Scheme |
α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 43 percent / acetic anhydride / 4 h / 90 °C 2: 1.) concd. HCl, 2.) p-TSA, H2O / 1.) ethanol, reflux, 24 h, 2.) acetone, reflux, 2 d 3: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h 4: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT 5: toluene / 6 h / Heating View Scheme |
α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid, ethyl ester
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: NaOH / methanol; H2O / 2 h / Heating 2: 43 percent / acetic anhydride / 4 h / 90 °C 3: 1.) concd. HCl, 2.) p-TSA, H2O / 1.) ethanol, reflux, 24 h, 2.) acetone, reflux, 2 d 4: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h 5: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT 6: toluene / 6 h / Heating View Scheme |
5-(4-fluorophenyl)-2-(1-methylethyl)-1-(3-oxopropyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h 2: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT 3: toluene / 6 h / Heating View Scheme |
1-<2-(1,3-dioxolan-2-yl)ethyl>-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) concd. HCl, 2.) p-TSA, H2O / 1.) ethanol, reflux, 24 h, 2.) acetone, reflux, 2 d 2: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h 3: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT 4: toluene / 6 h / Heating View Scheme |
methyl (R)-(+)-5-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-3-hydroxy-1-pentanoate
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 73 g / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 4 h / -70 °C View Scheme |
(R*,R*)-3,5-dihydroxy-7-<(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-1-heptanoic acid
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene / 6 h / Heating View Scheme |
methyl 7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT 2: toluene / 6 h / Heating View Scheme |
*,S*)>-5-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-3-hydroxy-1-pentanoic acid, 2-hydroxy-1,2,2-triphenylethyl ester
atorvastatin lactone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 73.9 g / methanol; tetrahydrofuran / 0 °C 2: 73 g / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 4 h / -70 °C View Scheme |
[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid; ammonium salt
atorvastatin lactone
Conditions | Yield |
---|---|
In toluene for 12h; Heating / reflux; |
atorvastatin lactone
1-((3R,5R)-3,5-dihydroxy-7-(hydroxyamino)-7-oxoheptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-7H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With hydroxylamine In tetrahydrofuran; water for 48h; | 99% |
With magnesium(II) bromide; hydroxylamine hydrochloride; sodium hydrogencarbonate In tetrahydrofuran; methanol at 20℃; for 20h; | 51% |
atorvastatin lactone
tetraethyl 3-aminopropylidene-1,1-bisphosphonate
tetraethyl (3R,5R)-3-N-(7-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)aminopropane-1,1-bisphosphonate
Conditions | Yield |
---|---|
In tetrahydrofuran at 60℃; for 48h; | 96.3% |
atorvastatin lactone
lipitor
Conditions | Yield |
---|---|
Stage #1: atorvastatin lactone With calcium hydroxide In tetrahydrofuran; water at 45 - 50℃; for 2h; Stage #2: In dichloromethane; di-isopropyl ether at 10 - 15℃; for 0.25h; Product distribution / selectivity; | 95.1% |
Stage #1: atorvastatin lactone With sodium hydroxide In methanol; water at 25 - 50℃; for 2h; Stage #2: With hydrogenchloride In water pH=7.8 - 8.2; Stage #3: With calcium acetate In methanol; water at 25 - 30℃; Product distribution / selectivity; | 92.21% |
Stage #1: atorvastatin lactone With calcium hydroxide In tetrahydrofuran; water at 45 - 50℃; for 2h; Stage #2: In methanol at 40 - 45℃; Product distribution / selectivity; | 91.82% |
atorvastatin lactone
1-[2-((2R,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: atorvastatin lactone With diisobutylaluminium hydride In dichloromethane; toluene at -78℃; for 1h; Stage #2: With water; rochelle salt In dichloromethane; toluene at 20℃; Product distribution / selectivity; | 95% |
Conditions | Yield |
---|---|
Stage #1: atorvastatin lactone With sodium hydroxide In methanol; tert-butyl methyl ether; water at 50℃; for 2h; Stage #2: calcium acetate hydrate In water at 30 - 50℃; for 4.5h; Heating; | 94% |
atorvastatin lactone
tert-butyldimethylsilyl chloride
(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide | 92% |
Conditions | Yield |
---|---|
Stage #1: strontium hydroxide; atorvastatin lactone With water In tert-butyl methyl ether; acetone at 20℃; for 3.5h; Stage #2: strontium(II) acetate With water In acetone at 50℃; for 10h; Product distribution / selectivity; | 85% |
atorvastatin lactone
Conditions | Yield |
---|---|
Stage #1: atorvastatin lactone With strontium hydroxide In tert-butyl methyl ether; water; acetone at 20℃; Stage #2: With strontium(II) acetate In water; acetone at 50℃; Product distribution / selectivity; | 85% |
Conditions | Yield |
---|---|
Stage #1: strontium hydroxide; atorvastatin lactone In methanol; tert-butyl methyl ether; water at 20℃; for 3.5h; Stage #2: strontium(II) acetate In methanol; tert-butyl methyl ether; water at 50℃; for 19h; | 77% |
Conditions | Yield |
---|---|
Stage #1: atorvastatin lactone With methanol; sodium hydroxide; water Stage #2: calcium chloride In water | 77% |
atorvastatin lactone
(R)-2-[(2-aminoethoxy)methyl]4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
Conditions | Yield |
---|---|
In ethanol for 18h; Heating / reflux; | 76% |
atorvastatin lactone
Conditions | Yield |
---|---|
With 1H-imidazole; tert-butyldimethylsilyl chloride In DMF (N,N-dimethyl-formamide) at 20℃; for 6h; | 73% |
atorvastatin lactone
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; for 24h; | 71% |
atorvastatin lactone
amlodipine
Conditions | Yield |
---|---|
In ethanol for 18h; Heating / reflux; | 64% |
atorvastatin lactone
tetraethyl (aminomethylene)bis(phosphonate)
tetraethyl [(3R,5R)-(7-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)aminomethylene]bisphosphonate
Conditions | Yield |
---|---|
In tetrahydrofuran at 60℃; for 48h; | 62.3% |
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