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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Atorvastatin lactone

Cas:125995-03-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 99.9%min 99.9% Hangzhou Dingyan Chem is a leading manufacturer and supplier of che

High quality 125995-03-1 Atorvastatin lactone

Cas:125995-03-1

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1600.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Atorvastatin lactone

Cas:125995-03-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationship

125995-03-1 Atorvastatin lactone

Cas:125995-03-1

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Atorvastatin lactone CAS 125995-03-1

Cas:125995-03-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 125995-03-1 with competitive price

Cas:125995-03-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 125995-03-1 Atorvastatin lactone with best price

Cas:125995-03-1

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Qingdao Beluga Import and Export Co., LTD

Atorvastatin lactone CAS:125995-03-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

Atorvastatin lactone CAS:125995-03-1

Cas:125995-03-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Atorvastatin Lactone

Cas:125995-03-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Atorvastatin lactone Synonyms: 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide;Atorvastatin d-Lactone;Atorvastatin EP Impurity H (USP RC H)Ato

Atorvastatin lactone supplier best quality

Cas:125995-03-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Atorvastatin lactone

Cas:125995-03-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Atorvastatin lactone

Cas:125995-03-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-

Cas:125995-03-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Atorvastatin lactone CAS NO.125995-03-1

Cas:125995-03-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

Atorvastatin LactoneAppearance:Pls see the Details Storage:Keep away of light, hot, water, Store in dry, dark and ventilated place Package:according to customers' requirements Application:Steroids, Cosmetics Ingredients, APIs, Intermediates, OLED&Bat

Atorvastatin Lactone

Cas:125995-03-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide interm

Atorvastatin lactone

Cas:125995-03-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 5-(4-Fluorophenyl)-2-(1-Methylethyl)-N,4-Diphenyl-1-[2-[(2R,4R)-Tetrahydro-4-Hydroxy-6-oxo--2H-Pyran-2-yl]ethyl]-1H-Pyrrole-3-Carboxamide CAS No.:125995-03-1 Molecule Formula:C33H33FN2O4 Molecule Weight:540.62 Purity: 99.0%

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Atorvastatin lactone

Cas:125995-03-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Atorvastatin lactone

Cas:125995-03-1

Min.Order:0

Negotiable

Type:Other

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

Atorvastatin Lactone

Cas:125995-03-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Atorvastatin Lactone

Cas:125995-03-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Atorvastatin lactone

Cas:125995-03-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

pentan-1-ol
71-41-0

pentan-1-ol

lipitor
134523-03-8

lipitor

A

pentyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

pentyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 96%
B n/a
1-[2-((2R,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
842163-03-5

1-[2-((2R,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With manganese(IV) oxide In acetone at 25℃; for 24h;95%
With Dess-Martin periodane In dichloromethane at 20℃; for 2.5h;
2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid
581772-29-4

2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With camphor-10-sulfonic acid In tetrahydrofuran at 20℃; for 3h;90%
lipitor
134523-03-8

lipitor

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Stage #1: lipitor With hydrogenchloride In water; ethyl acetate at 4 - 20℃;
Stage #2: In toluene for 2.5h; Reflux; Dean-Stark;
88%
With hydrogenchloride In water at 20℃; for 2h;55%
Stage #1: lipitor With hydrogenchloride In dichloromethane; water
Stage #2: With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Cooling with ice;
2.78 g
(3R,5R)-methyl 3,5-bis((tert-butyldimethylsilyl)oxy)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate

(3R,5R)-methyl 3,5-bis((tert-butyldimethylsilyl)oxy)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 20℃; stereoselective reaction;75%
2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

lipitor
134523-03-8

lipitor

A

isobutyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

isobutyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 74%
B n/a
propan-1-ol
71-23-8

propan-1-ol

lipitor
134523-03-8

lipitor

A

propyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

propyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 70%
B n/a
n-heptan1ol
111-70-6

n-heptan1ol

lipitor
134523-03-8

lipitor

A

heptyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

heptyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 68%
B n/a
lipitor
134523-03-8

lipitor

hexan-1-ol
111-27-3

hexan-1-ol

A

hexyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

hexyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 66%
B n/a
lipitor
134523-03-8

lipitor

nonyl alcohol
143-08-8

nonyl alcohol

A

nonyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

nonyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 66%
B n/a
lipitor
134523-03-8

lipitor

A

(S)-5-(4-fluorophenyl)-2-isopropyl-1-(2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
442851-50-5

(S)-5-(4-fluorophenyl)-2-isopropyl-1-(2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With hydrogenchloride In water for 4h; Reflux;A 14%
B 65%
lipitor
134523-03-8

lipitor

isopropyl alcohol
67-63-0

isopropyl alcohol

A

(3R,5R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate
1035205-25-4

(3R,5R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 54%
B n/a
atorvastatin
134523-00-5

atorvastatin

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
In toluene at 60℃; for 40h;46%
hydrogenchloride In toluenen/a
In toluene for 4h; Product distribution / selectivity; Heating / reflux;
In hexane for 6h; Heating;3.9 g
2,2-dimethyl-propanol-1
75-84-3

2,2-dimethyl-propanol-1

lipitor
134523-03-8

lipitor

A

neopentyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

neopentyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

B

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;A 44%
B n/a
1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate
134394-98-2

1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Yield given. Multistep reaction;
(+/-)-trans-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-<2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-3-carboxamide
110862-39-0, 125995-03-1, 134523-07-2

(+/-)-trans-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-<2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-3-carboxamide

A

atorvastatin lactone
125995-03-1

atorvastatin lactone

B

(-)-(4S)-trans-2-(4-fluorophenyl)-5-(1-methylethyl)-N,3-diphenyl-1-<(tetrahydro-4-hydroxy-2-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-4-carboxamide
134523-07-2

(-)-(4S)-trans-2-(4-fluorophenyl)-5-(1-methylethyl)-N,3-diphenyl-1-<(tetrahydro-4-hydroxy-2-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-4-carboxamide

Conditions
ConditionsYield
Yield given. Yields of byproduct given;
methanol
67-56-1

methanol

atorvastatin
134523-00-5

atorvastatin

A

atorvastatin lactone
125995-03-1

atorvastatin lactone

B

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
345891-62-5

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With phosphoric acid In acetonitrile at 80℃; for 3h;A 15.2 mg
B 6.9 mg
ethyl α-bromo-4-fluorobenzeneacetate

ethyl α-bromo-4-fluorobenzeneacetate

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 82.5 percent / triethylamine / acetonitrile / Ambient temperature
2: triethylamine / CH2Cl2 / 1 h / 0 °C
3: NaOH / methanol; H2O / 2 h / Heating
4: 43 percent / acetic anhydride / 4 h / 90 °C
5: 1.) concd. HCl, 2.) p-TSA, H2O / 1.) ethanol, reflux, 24 h, 2.) acetone, reflux, 2 d
6: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h
7: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT
8: toluene / 6 h / Heating
View Scheme
ethyl 3-(4-cyanophenyl)propiolate
143952-58-3

ethyl 3-(4-cyanophenyl)propiolate

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
2: 73.9 g / methanol; tetrahydrofuran / 0 °C
3: 73 g / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 4 h / -70 °C
View Scheme
ethyl α-<<2-(1,3-dioxolan-2-yl)ethyl>amino>-4-fluorobenzeneacetate

ethyl α-<<2-(1,3-dioxolan-2-yl)ethyl>amino>-4-fluorobenzeneacetate

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: triethylamine / CH2Cl2 / 1 h / 0 °C
2: NaOH / methanol; H2O / 2 h / Heating
3: 43 percent / acetic anhydride / 4 h / 90 °C
4: 1.) concd. HCl, 2.) p-TSA, H2O / 1.) ethanol, reflux, 24 h, 2.) acetone, reflux, 2 d
5: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h
6: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT
7: toluene / 6 h / Heating
View Scheme
α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid
110862-44-7

α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 43 percent / acetic anhydride / 4 h / 90 °C
2: 1.) concd. HCl, 2.) p-TSA, H2O / 1.) ethanol, reflux, 24 h, 2.) acetone, reflux, 2 d
3: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h
4: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT
5: toluene / 6 h / Heating
View Scheme
α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid, ethyl ester
110862-43-6

α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid, ethyl ester

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NaOH / methanol; H2O / 2 h / Heating
2: 43 percent / acetic anhydride / 4 h / 90 °C
3: 1.) concd. HCl, 2.) p-TSA, H2O / 1.) ethanol, reflux, 24 h, 2.) acetone, reflux, 2 d
4: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h
5: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT
6: toluene / 6 h / Heating
View Scheme
5-(4-fluorophenyl)-2-(1-methylethyl)-1-(3-oxopropyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
110862-46-9

5-(4-fluorophenyl)-2-(1-methylethyl)-1-(3-oxopropyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h
2: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT
3: toluene / 6 h / Heating
View Scheme
1-<2-(1,3-dioxolan-2-yl)ethyl>-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
110862-45-8

1-<2-(1,3-dioxolan-2-yl)ethyl>-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) concd. HCl, 2.) p-TSA, H2O / 1.) ethanol, reflux, 24 h, 2.) acetone, reflux, 2 d
2: 1.) sodium hydride, n-butyllithium / 1.) THF, hexane, 0 deg C, 30 min, 2.)a) -78 deg C, 30 min, b) 0 deg C, 1 h
3: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT
4: toluene / 6 h / Heating
View Scheme
methyl (R)-(+)-5-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-3-hydroxy-1-pentanoate
134394-97-1

methyl (R)-(+)-5-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-3-hydroxy-1-pentanoate

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 73 g / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 4 h / -70 °C
View Scheme
(R*,R*)-3,5-dihydroxy-7-<(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-1-heptanoic acid
125971-63-3

(R*,R*)-3,5-dihydroxy-7-<(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-1-heptanoic acid

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / 6 h / Heating
View Scheme
methyl 7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate
110862-47-0

methyl 7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) tributylborane, sodium borohydride, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, a) RT, b) 0 deg C, 3 h, 2.) RT
2: toluene / 6 h / Heating
View Scheme
*,S*)>-5-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-3-hydroxy-1-pentanoic acid, 2-hydroxy-1,2,2-triphenylethyl ester
134394-96-0

*,S*)>-5-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-3-hydroxy-1-pentanoic acid, 2-hydroxy-1,2,2-triphenylethyl ester

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 73.9 g / methanol; tetrahydrofuran / 0 °C
2: 73 g / diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 4 h / -70 °C
View Scheme
[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid; ammonium salt
340266-37-7

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid; ammonium salt

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
In toluene for 12h; Heating / reflux;
atorvastatin lactone
125995-03-1

atorvastatin lactone

1-((3R,5R)-3,5-dihydroxy-7-(hydroxyamino)-7-oxoheptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-7H-pyrrole-3-carboxamide
1174332-81-0

1-((3R,5R)-3,5-dihydroxy-7-(hydroxyamino)-7-oxoheptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-7H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With hydroxylamine In tetrahydrofuran; water for 48h;99%
With magnesium(II) bromide; hydroxylamine hydrochloride; sodium hydrogencarbonate In tetrahydrofuran; methanol at 20℃; for 20h;51%
atorvastatin lactone
125995-03-1

atorvastatin lactone

tetraethyl 3-aminopropylidene-1,1-bisphosphonate
141473-49-6

tetraethyl 3-aminopropylidene-1,1-bisphosphonate

tetraethyl (3R,5R)-3-N-(7-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)aminopropane-1,1-bisphosphonate
1040395-59-2

tetraethyl (3R,5R)-3-N-(7-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)aminopropane-1,1-bisphosphonate

Conditions
ConditionsYield
In tetrahydrofuran at 60℃; for 48h;96.3%
atorvastatin lactone
125995-03-1

atorvastatin lactone

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: atorvastatin lactone With calcium hydroxide In tetrahydrofuran; water at 45 - 50℃; for 2h;
Stage #2: In dichloromethane; di-isopropyl ether at 10 - 15℃; for 0.25h; Product distribution / selectivity;
95.1%
Stage #1: atorvastatin lactone With sodium hydroxide In methanol; water at 25 - 50℃; for 2h;
Stage #2: With hydrogenchloride In water pH=7.8 - 8.2;
Stage #3: With calcium acetate In methanol; water at 25 - 30℃; Product distribution / selectivity;
92.21%
Stage #1: atorvastatin lactone With calcium hydroxide In tetrahydrofuran; water at 45 - 50℃; for 2h;
Stage #2: In methanol at 40 - 45℃; Product distribution / selectivity;
91.82%
atorvastatin lactone
125995-03-1

atorvastatin lactone

1-[2-((2R,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
842163-03-5

1-[2-((2R,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Stage #1: atorvastatin lactone With diisobutylaluminium hydride In dichloromethane; toluene at -78℃; for 1h;
Stage #2: With water; rochelle salt In dichloromethane; toluene at 20℃; Product distribution / selectivity;
95%
calcium acetate hydrate
114460-21-8

calcium acetate hydrate

atorvastatin lactone
125995-03-1

atorvastatin lactone

2C33H36FN2O5(1-)*Ca(2+)

2C33H36FN2O5(1-)*Ca(2+)

Conditions
ConditionsYield
Stage #1: atorvastatin lactone With sodium hydroxide In methanol; tert-butyl methyl ether; water at 50℃; for 2h;
Stage #2: calcium acetate hydrate In water at 30 - 50℃; for 4.5h; Heating;
94%
atorvastatin lactone
125995-03-1

atorvastatin lactone

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
842162-99-6

(2R,4R)-1-{2-[4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide92%
strontium hydroxide
1311-10-0

strontium hydroxide

strontium(II) acetate
543-94-2

strontium(II) acetate

atorvastatin lactone
125995-03-1

atorvastatin lactone

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoate strontium pentahydrate

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoate strontium pentahydrate

Conditions
ConditionsYield
Stage #1: strontium hydroxide; atorvastatin lactone With water In tert-butyl methyl ether; acetone at 20℃; for 3.5h;
Stage #2: strontium(II) acetate With water In acetone at 50℃; for 10h; Product distribution / selectivity;
85%
atorvastatin lactone
125995-03-1

atorvastatin lactone

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoate strontium

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoate strontium

Conditions
ConditionsYield
Stage #1: atorvastatin lactone With strontium hydroxide In tert-butyl methyl ether; water; acetone at 20℃;
Stage #2: With strontium(II) acetate In water; acetone at 50℃; Product distribution / selectivity;
85%
strontium hydroxide
1311-10-0

strontium hydroxide

strontium(II) acetate
543-94-2

strontium(II) acetate

atorvastatin lactone
125995-03-1

atorvastatin lactone

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoate strontium

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoate strontium

Conditions
ConditionsYield
Stage #1: strontium hydroxide; atorvastatin lactone In methanol; tert-butyl methyl ether; water at 20℃; for 3.5h;
Stage #2: strontium(II) acetate In methanol; tert-butyl methyl ether; water at 50℃; for 19h;
77%
atorvastatin lactone
125995-03-1

atorvastatin lactone

calcium chloride

calcium chloride

atorvastatin calcium

atorvastatin calcium

Conditions
ConditionsYield
Stage #1: atorvastatin lactone With methanol; sodium hydroxide; water
Stage #2: calcium chloride In water
77%
atorvastatin lactone
125995-03-1

atorvastatin lactone

(R)-2-[(2-aminoethoxy)methyl]4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
103129-81-3

(R)-2-[(2-aminoethoxy)methyl]4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester

(R)-3-ethyl-5-methyl-2-{[2-({7-[(3-anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoyl}amino)ethoxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate

(R)-3-ethyl-5-methyl-2-{[2-({7-[(3-anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoyl}amino)ethoxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate

Conditions
ConditionsYield
In ethanol for 18h; Heating / reflux;76%
atorvastatin lactone
125995-03-1

atorvastatin lactone

(2R,4R)-1-{2-[4-(tert-Butyldimethylsilyloxy)-6-oxotetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

(2R,4R)-1-{2-[4-(tert-Butyldimethylsilyloxy)-6-oxotetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

Conditions
ConditionsYield
With 1H-imidazole; tert-butyldimethylsilyl chloride In DMF (N,N-dimethyl-formamide) at 20℃; for 6h;73%
atorvastatin lactone
125995-03-1

atorvastatin lactone

1-((3R,5R)-7-amino-3,5-dihydroxy-7-oxoheptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide

1-((3R,5R)-7-amino-3,5-dihydroxy-7-oxoheptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With ammonia In methanol at 20℃; for 24h;71%
atorvastatin lactone
125995-03-1

atorvastatin lactone

amlodipine
103129-82-4

amlodipine

(S)-3-ethyl-5-methyl-2-{[2-({7-[(3-anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoyl}amino)ethoxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate

(S)-3-ethyl-5-methyl-2-{[2-({7-[(3-anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoyl}amino)ethoxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate

Conditions
ConditionsYield
In ethanol for 18h; Heating / reflux;64%
atorvastatin lactone
125995-03-1

atorvastatin lactone

tetraethyl (aminomethylene)bis(phosphonate)
80474-99-3

tetraethyl (aminomethylene)bis(phosphonate)

tetraethyl [(3R,5R)-(7-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)aminomethylene]bisphosphonate
1040395-64-9

tetraethyl [(3R,5R)-(7-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)aminomethylene]bisphosphonate

Conditions
ConditionsYield
In tetrahydrofuran at 60℃; for 48h;62.3%

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