As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
Name:Atorvastatin The alias:Atorvastatin Acid CAS NO:134523-00-5 Molecular formula:C33H33CaFNO5 Molecular weight:582.6947 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Secu
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
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inquiryProduct name Atorvastatin Specification EP CAS 134523-00-5 Package 25kg net per drum. Stock Fresh stock; good price; samples a
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryProduct Name: Atorvastatin CAS: 134523-00-5 MF: C33H35FN2O5 MW: 558.65 EINECS: 806-698-0 Product Categories: Mol File: 134523-00-5.mol Atorvastatin Structure Atorvastatin Chemical Properties Melting point 176-178°C Boil
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
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inquiryAtorvastatin CAS:134523-00-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
in Synonyms: Atorvastatin (Subject to Patent free);(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid;Atorvastatin&Ats-5Ats-8Ats-9M4L1;(bR,dR)-2-(p-Fluorophenyl)-β,δ-d
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquirySuperior quality, moderate price & quick delivery. Appearance:white crystal or crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , p
Product name: (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Phenylcarbamoyl)pyrrol-1-yl]-3,5-Dihydro Heptanoic Acid CAS No.:134523-00-5 Molecule Formula:C33H33CaFNO5 Molecule Weight:582.69 Purity: 99.0% Package: 25kg/drum Descri
Cas:134523-00-5
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
atorvastatin sodium
atorvastatin
Conditions | Yield |
---|---|
With sodium hydroxide at 60 - 70℃; pH=12-13; | 95% |
With hydrogenchloride In dichloromethane; water for 0.5h; Cooling with ice; | 94% |
lipitor
atorvastatin
Conditions | Yield |
---|---|
With hydrogenchloride In tert-butyl methyl ether; water | 92% |
With hydrogenchloride In water; acetonitrile at 20℃; for 0.25h; pH=2.35 - 7; | |
With sodium hydrogen sulfate In water; ethyl acetate |
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
atorvastatin
Conditions | Yield |
---|---|
With Trimethylacetic acid In toluene at 90℃; for 22h; Solvent; Temperature; | 91% |
(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester
atorvastatin
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; water at 20℃; Hydrolysis; | |
With methanol; potassium hydroxide; water | |
Stage #1: (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester With methanol; sodium hydroxide; water In tert-butyl methyl ether for 2.08333 - 7.08333h; Heating / reflux; Stage #2: With hydrogenchloride pH=8.0 - 8.2; |
4-methyl-3-oxo-N-phenylpentanamide
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: β-alanine; glacial acetic acid / hexane / Heating 2: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating 3: pivalic acid / tetrahydrofuran; toluene; heptane / Heating 4: HCl / tetrahydrofuran; H2O / 20 °C 5: sodium hydroxide / H2O; tetrahydrofuran / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: β-alanine; glacial acetic acid / hexane / Heating 2: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating 3: pivalic acid / tetrahydrofuran; toluene; heptane / Heating 4: HCl / tetrahydrofuran; H2O / 20 °C 5: sodium hydroxide / H2O; tetrahydrofuran / 20 °C View Scheme |
4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating 2: pivalic acid / tetrahydrofuran; toluene; heptane / Heating 3: HCl / tetrahydrofuran; H2O / 20 °C 4: sodium hydroxide / H2O; tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / Reflux 2.1: Trimethylacetic acid / toluene; hexane; tetrahydrofuran / Reflux 3.1: hydrogenchloride / methanol / 0.08 h / 60 °C 3.2: 0.08 h / 60 °C View Scheme |
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pivalic acid / tetrahydrofuran; toluene; heptane / Heating 2: HCl / tetrahydrofuran; H2O / 20 °C 3: sodium hydroxide / H2O; tetrahydrofuran / 20 °C View Scheme |
tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCl / tetrahydrofuran; H2O / 20 °C 2: sodium hydroxide / H2O; tetrahydrofuran / 20 °C View Scheme | |
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In tetrahydrofuran; methanol at 20℃; Stage #2: With sodium hydroxide; water In tetrahydrofuran; methanol at 0 - 20℃; | |
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In tetrahydrofuran at 25℃; for 8h; Stage #2: With sodium hydroxide; water In tetrahydrofuran for 8h; Stage #3: With phosphoric acid In water; ethyl acetate pH=4.0; Product distribution / selectivity; |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 96 percent / toluene / Heating 2: β-alanine; glacial acetic acid / hexane / Heating 3: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating 4: pivalic acid / tetrahydrofuran; toluene; heptane / Heating 5: HCl / tetrahydrofuran; H2O / 20 °C 6: sodium hydroxide / H2O; tetrahydrofuran / 20 °C View Scheme |
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 96 percent / toluene / Heating 2: β-alanine; glacial acetic acid / hexane / Heating 3: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating 4: pivalic acid / tetrahydrofuran; toluene; heptane / Heating 5: HCl / tetrahydrofuran; H2O / 20 °C 6: sodium hydroxide / H2O; tetrahydrofuran / 20 °C View Scheme |
((4R,6R)-6-(2-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrole-1-yl]-ethyl)-2-phenethyl-[1,3,2]dioxaborinane-4-yl)-acetic acid t-butyl ester
atorvastatin
Conditions | Yield |
---|---|
Stage #1: ((4R,6R)-6-(2-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrole-1-yl]-ethyl)-2-phenethyl-[1,3,2]dioxaborinane-4-yl)-acetic acid t-butyl ester With sodium hydroxide; water In ethyl acetate for 0.5h; Stage #2: With hydrogenchloride; water In ethyl acetate for 0.5h; pH=1 - ~ 2; |
(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
B
(2E,5S)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxyhept-2-enoic acid
C
atorvastatin
Conditions | Yield |
---|---|
Stage #1: (3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate With dmap; acetic anhydride; triethylamine In toluene at 60℃; for 2h; Stage #2: With sodium hydroxide In tetrahydrofuran; water; toluene at 25℃; for 16h; Further stages.; |
(R)-N,N-diallyl-5-(benzyloxy)-3-hydroxypentanethioamide
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1.1: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C 2.1: diethyl ether / 4.5 h / 0 - 20 °C 3.1: tetrahydrofuran; diethyl ether / -78 °C 3.2: -78 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 - 20 °C 5.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C 6.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C 7.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr 8.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C 9.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C 10.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C 11.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere 12.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C 13.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C 13.2: 20 °C View Scheme |
(R)-N,N-diallyl-5-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)pentanethioamide
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1.1: diethyl ether / 4.5 h / 0 - 20 °C 2.1: tetrahydrofuran; diethyl ether / -78 °C 2.2: -78 °C 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 - 20 °C 4.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C 5.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C 6.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr 7.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C 8.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C 9.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C 10.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere 11.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C 12.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C 12.2: 20 °C View Scheme |
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: tetrahydrofuran; diethyl ether / -78 °C 1.2: -78 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 - 20 °C 3.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C 4.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C 5.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr 6.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C 7.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C 8.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C 9.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere 10.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C 11.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C 11.2: 20 °C View Scheme |
(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 - 20 °C 2.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C 3.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C 4.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr 5.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C 6.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C 7.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C 8.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere 9.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C 10.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C 10.2: 20 °C View Scheme |
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C 2.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C 3.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr 4.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C 5.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C 6.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C 7.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere 8.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C 9.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C 9.2: 20 °C View Scheme |
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C 2.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr 3.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C 4.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C 5.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C 6.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere 7.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C 8.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C 8.2: 20 °C View Scheme |
tert-butyl 2-((4R,6R)-6-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr 2.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C 4.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C 5.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere 6.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C 7.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C 7.2: 20 °C View Scheme |
tert-butyl 2-((4R,6R)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C 2.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C 3.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C 4.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere 5.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C 6.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C 6.2: 20 °C View Scheme |
tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C 2.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C 3.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere 4.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C 5.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C 5.2: 20 °C View Scheme |
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
atorvastatin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere 2.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C 3.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C 3.2: 20 °C View Scheme |
Conditions | Yield |
---|---|
In methanol; ethyl acetate at 25℃; for 1h; | 96% |
In ethanol; water at 75℃; |
Conditions | Yield |
---|---|
In ethyl acetate at 25℃; for 24h; | 95% |
In dichloromethane at 25℃; for 24h; | 72% |
In isopropyl alcohol at 20℃; for 168h; | |
In ethanol; water at 75℃; |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 60 - 70℃; pH=7 - 8; | 93% |
Conditions | Yield |
---|---|
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 30℃; for 9h; | 91% |
atorvastatin
Conditions | Yield |
---|---|
With calcium hydroxide; water In methanol Product distribution / selectivity; Heating / reflux; | 88% |
With calcium hydroxide; water In acetone at 20 - 25℃; for 50.0333h; Product distribution / selectivity; | 68% |
With sodium hydroxide; calcium acetate In tert-butyl methyl ether; water; isopropyl alcohol for 24h; Product distribution / selectivity; | |
With sodium hydroxide; calcium chloride In water at 20 - 80℃; for 21.5h; Product distribution / selectivity; |
atorvastatin
1-((3R,5R)-3,5-dihydroxy-7-(hydroxyamino)-7-oxoheptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-7H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With hydroxylamine In tetrahydrofuran; water at 20℃; for 1h; | 88% |
Conditions | Yield |
---|---|
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 6h; | 88% |
Conditions | Yield |
---|---|
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 12h; | 88% |
Conditions | Yield |
---|---|
Stage #1: atorvastatin With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: C21H19BrNO4(1+)*Br(1-) In N,N-dimethyl-formamide at 70℃; | 87% |
Conditions | Yield |
---|---|
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 35℃; for 12h; | 86% |
Conditions | Yield |
---|---|
Stage #1: calcium acetate; atorvastatin In water; acetonitrile at 44℃; for 1.25h; Stage #2: With sodium hydroxide In water at 30 - 70℃; for 9.5h; Product distribution / selectivity; | 84.35% |
D-lysine
atorvastatin
(3R,5R)-7-[3-phenyl-4-[(phenylamino)carbonyl]-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid D-lysine salt
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 20h; | 76% |
2,6-diaminocaproic acid
atorvastatin
(3R,5R)-7-[3-phenyl-4-[(phenylamino)carbonyl]-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid DL-lysine salt
Conditions | Yield |
---|---|
In ethyl acetate | 65% |
L-ornithine
atorvastatin
Conditions | Yield |
---|---|
In ethyl acetate | 47% |
atorvastatin
atorvastatin lactone
Conditions | Yield |
---|---|
In toluene at 60℃; for 40h; | 46% |
hydrogenchloride In toluene | n/a |
In toluene for 4h; Product distribution / selectivity; Heating / reflux; | |
In hexane for 6h; Heating; | 3.9 g |
2,2-dimethoxy-propane
atorvastatin
2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In acetone at 20℃; for 15h; | 46% |
In dichloromethane at 20℃; |
atorvastatin
1-((19R,21R)-1-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-ylamino)-19,21-dihydroxy-17-oxo-1-thioxo-6,9,12-trioxa-2,16-diazatricosan-23-yl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 36h; | 41% |
1-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-3-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)thiourea
atorvastatin
1-((19R,21R)-1-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-ylamino)-19,21-dihydroxy-17-oxo-1-thioxo-6,9,12-trioxa-2,16-diazatricosan-23-yl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 36h; | 41% |
methanol
atorvastatin
A
atorvastatin lactone
B
(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
Conditions | Yield |
---|---|
With phosphoric acid In acetonitrile at 80℃; for 3h; | A 15.2 mg B 6.9 mg |
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