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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Atorvastatin Manufacturer/High quality/Best price/In stock

Cas:134523-00-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Atorvastatin 134523-00-5 GMP manufacturer

Cas:134523-00-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

Atorvastatin

Cas:134523-00-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Atorvastatin The alias:Atorvastatin Acid CAS NO:134523-00-5 Molecular formula:C33H33CaFNO5 Molecular weight:582.6947 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Secu

Atorvastatin/CAS:134523-00-5/Raw material supply

Cas:134523-00-5

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Atorvastatin CAS 134523-00-5

Cas:134523-00-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Atorvastatin 134523-00-5

Cas:134523-00-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 134523-00-5 with competitive price

Cas:134523-00-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Atorvastatin CAS134523-00-5

Cas:134523-00-5

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name Atorvastatin Specification EP CAS 134523-00-5 Package 25kg net per drum. Stock Fresh stock; good price; samples a

Atorvastatin

Cas:134523-00-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Atorvastatin Manufacturer For Hypolipidemic Drugs

Cas:134523-00-5

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Atorvastatin 134523-00-5

Cas:134523-00-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Atorvastatin Medicine powder Atorvastatin Powder Material Atorvastatin

Cas:134523-00-5

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Product Name: Atorvastatin CAS: 134523-00-5 MF: C33H35FN2O5 MW: 558.65 EINECS: 806-698-0 Product Categories: Mol File: 134523-00-5.mol Atorvastatin Structure Atorvastatin Chemical Properties Melting point 176-178°C Boil

Atorvastatin

Cas:134523-00-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

atorvastatin api with GMP DMF high quality CAS 134523-00-5

Cas:134523-00-5

Min.Order:1 Kilogram

FOB Price: $110.0 / 120.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Atorvastatin CAS:134523-00-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Atorvastatin CAS:134523-00-5

Cas:134523-00-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Atorvastatin

Cas:134523-00-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

in Synonyms: Atorvastatin (Subject to Patent free);(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid;Atorvastatin&Ats-5Ats-8Ats-9M4L1;(bR,dR)-2-(p-Fluorophenyl)-β,δ-d

Atorvastatin (Subject to Patent free) Manufactory best quality

Cas:134523-00-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Atorvastatin

Cas:134523-00-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Atorvastatin

Cas:134523-00-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Atorvastatin

Cas:134523-00-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Atorvastatin

Cas:134523-00-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ATORVASTATIN ACID

Cas:134523-00-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Atorvastatin

Cas:134523-00-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal or crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , p

Atorvastatin

Cas:134523-00-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Phenylcarbamoyl)pyrrol-1-yl]-3,5-Dihydro Heptanoic Acid CAS No.:134523-00-5 Molecule Formula:C33H33CaFNO5 Molecule Weight:582.69 Purity: 99.0% Package: 25kg/drum Descri

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Atorvastatin

Cas:134523-00-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferAtorvastatin

Cas:134523-00-5

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

atorvastatin sodium
134523-01-6

atorvastatin sodium

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
With sodium hydroxide at 60 - 70℃; pH=12-13;95%
With hydrogenchloride In dichloromethane; water for 0.5h; Cooling with ice;94%
lipitor
134523-03-8

lipitor

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
With hydrogenchloride In tert-butyl methyl ether; water92%
With hydrogenchloride In water; acetonitrile at 20℃; for 0.25h; pH=2.35 - 7;
With sodium hydrogen sulfate In water; ethyl acetate
C7H15NO4

C7H15NO4

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
With Trimethylacetic acid In toluene at 90℃; for 22h; Solvent; Temperature;91%
(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester
134395-00-9

(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃; Hydrolysis;
With methanol; potassium hydroxide; water
Stage #1: (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester With methanol; sodium hydroxide; water In tert-butyl methyl ether for 2.08333 - 7.08333h; Heating / reflux;
Stage #2: With hydrogenchloride pH=8.0 - 8.2;
4-methyl-3-oxo-N-phenylpentanamide
124401-38-3

4-methyl-3-oxo-N-phenylpentanamide

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: β-alanine; glacial acetic acid / hexane / Heating
2: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating
3: pivalic acid / tetrahydrofuran; toluene; heptane / Heating
4: HCl / tetrahydrofuran; H2O / 20 °C
5: sodium hydroxide / H2O; tetrahydrofuran / 20 °C
View Scheme
benzaldehyde
100-52-7

benzaldehyde

HI, I2

HI, I2

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: β-alanine; glacial acetic acid / hexane / Heating
2: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating
3: pivalic acid / tetrahydrofuran; toluene; heptane / Heating
4: HCl / tetrahydrofuran; H2O / 20 °C
5: sodium hydroxide / H2O; tetrahydrofuran / 20 °C
View Scheme
4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide
125971-57-5

4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating
2: pivalic acid / tetrahydrofuran; toluene; heptane / Heating
3: HCl / tetrahydrofuran; H2O / 20 °C
4: sodium hydroxide / H2O; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / Reflux
2.1: Trimethylacetic acid / toluene; hexane; tetrahydrofuran / Reflux
3.1: hydrogenchloride / methanol / 0.08 h / 60 °C
3.2: 0.08 h / 60 °C
View Scheme
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pivalic acid / tetrahydrofuran; toluene; heptane / Heating
2: HCl / tetrahydrofuran; H2O / 20 °C
3: sodium hydroxide / H2O; tetrahydrofuran / 20 °C
View Scheme
tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate
125971-95-1

tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / tetrahydrofuran; H2O / 20 °C
2: sodium hydroxide / H2O; tetrahydrofuran / 20 °C
View Scheme
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In tetrahydrofuran; methanol at 20℃;
Stage #2: With sodium hydroxide; water In tetrahydrofuran; methanol at 0 - 20℃;
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In tetrahydrofuran at 25℃; for 8h;
Stage #2: With sodium hydroxide; water In tetrahydrofuran for 8h;
Stage #3: With phosphoric acid In water; ethyl acetate pH=4.0; Product distribution / selectivity;
aniline
62-53-3

aniline

Wang resin-bound styrene 4

Wang resin-bound styrene 4

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 96 percent / toluene / Heating
2: β-alanine; glacial acetic acid / hexane / Heating
3: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating
4: pivalic acid / tetrahydrofuran; toluene; heptane / Heating
5: HCl / tetrahydrofuran; H2O / 20 °C
6: sodium hydroxide / H2O; tetrahydrofuran / 20 °C
View Scheme
isobutyryl Meldrum's acid

isobutyryl Meldrum's acid

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 96 percent / toluene / Heating
2: β-alanine; glacial acetic acid / hexane / Heating
3: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating
4: pivalic acid / tetrahydrofuran; toluene; heptane / Heating
5: HCl / tetrahydrofuran; H2O / 20 °C
6: sodium hydroxide / H2O; tetrahydrofuran / 20 °C
View Scheme
((4R,6R)-6-(2-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrole-1-yl]-ethyl)-2-phenethyl-[1,3,2]dioxaborinane-4-yl)-acetic acid t-butyl ester
1049684-97-0

((4R,6R)-6-(2-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrole-1-yl]-ethyl)-2-phenethyl-[1,3,2]dioxaborinane-4-yl)-acetic acid t-butyl ester

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Stage #1: ((4R,6R)-6-(2-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrole-1-yl]-ethyl)-2-phenethyl-[1,3,2]dioxaborinane-4-yl)-acetic acid t-butyl ester With sodium hydroxide; water In ethyl acetate for 0.5h;
Stage #2: With hydrogenchloride; water In ethyl acetate for 0.5h; pH=1 - ~ 2;
(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
345891-62-5

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

A

(2Z,5S)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxyhept-2-enoic acid

(2Z,5S)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxyhept-2-enoic acid

B

(2E,5S)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxyhept-2-enoic acid
1105067-93-3

(2E,5S)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxyhept-2-enoic acid

C

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Stage #1: (3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate With dmap; acetic anhydride; triethylamine In toluene at 60℃; for 2h;
Stage #2: With sodium hydroxide In tetrahydrofuran; water; toluene at 25℃; for 16h; Further stages.;
(R)-N,N-diallyl-5-(benzyloxy)-3-hydroxypentanethioamide
1331869-16-9

(R)-N,N-diallyl-5-(benzyloxy)-3-hydroxypentanethioamide

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C
2.1: diethyl ether / 4.5 h / 0 - 20 °C
3.1: tetrahydrofuran; diethyl ether / -78 °C
3.2: -78 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 - 20 °C
5.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C
6.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C
7.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr
8.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C
9.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C
10.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
11.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere
12.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
13.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C
13.2: 20 °C
View Scheme
(R)-N,N-diallyl-5-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)pentanethioamide
1347738-07-1

(R)-N,N-diallyl-5-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)pentanethioamide

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: diethyl ether / 4.5 h / 0 - 20 °C
2.1: tetrahydrofuran; diethyl ether / -78 °C
2.2: -78 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 - 20 °C
4.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C
5.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C
6.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr
7.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C
8.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C
9.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
10.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere
11.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
12.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C
12.2: 20 °C
View Scheme
CF3O3S(1-)*C25H42NO2SSi(1+)

CF3O3S(1-)*C25H42NO2SSi(1+)

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: tetrahydrofuran; diethyl ether / -78 °C
1.2: -78 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 - 20 °C
3.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C
4.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C
5.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr
6.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C
7.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C
8.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
9.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere
10.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
11.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C
11.2: 20 °C
View Scheme
(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate
1331869-20-5

(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 - 20 °C
2.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C
3.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C
4.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr
5.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C
6.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C
7.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
8.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere
9.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
10.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C
10.2: 20 °C
View Scheme
C18H26O5

C18H26O5

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C
2.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C
3.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr
4.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C
5.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C
6.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
7.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere
8.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
9.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C
9.2: 20 °C
View Scheme
C18H28O5

C18H28O5

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C
2.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr
3.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C
4.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C
5.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
6.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere
7.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
8.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C
8.2: 20 °C
View Scheme
tert-butyl 2-((4R,6R)-6-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
1331869-21-6

tert-butyl 2-((4R,6R)-6-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr
2.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C
3.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C
4.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
5.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere
6.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
7.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C
7.2: 20 °C
View Scheme
tert-butyl 2-((4R,6R)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
1173184-84-3

tert-butyl 2-((4R,6R)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C
2.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C
3.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
4.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere
5.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
6.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C
6.2: 20 °C
View Scheme
tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate
1331869-22-7

tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 °C
2.1: water; triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
3.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere
4.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
5.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C
5.2: 20 °C
View Scheme
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
125971-86-0, 125995-13-3

tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Trimethylacetic acid / tetrahydrofuran; hexane; toluene / 30 h / 110 °C / Inert atmosphere
2.1: hydrogenchloride / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
3.1: sodium hydroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C
3.2: 20 °C
View Scheme
L-arginine
74-79-3

L-arginine

atorvastatin
134523-00-5

atorvastatin

atorvastatin arginine

atorvastatin arginine

Conditions
ConditionsYield
In methanol; ethyl acetate at 25℃; for 1h;96%
In ethanol; water at 75℃;
L-lysine
56-87-1

L-lysine

atorvastatin
134523-00-5

atorvastatin

atorvastatin lysine

atorvastatin lysine

Conditions
ConditionsYield
In ethyl acetate at 25℃; for 24h;95%
In dichloromethane at 25℃; for 24h;72%
In isopropyl alcohol at 20℃; for 168h;
In ethanol; water at 75℃;
berberine chloride
633-65-8

berberine chloride

atorvastatin
134523-00-5

atorvastatin

C33H34FN2O5(1-)*C20H18NO4(1+)

C33H34FN2O5(1-)*C20H18NO4(1+)

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 60 - 70℃; pH=7 - 8;93%
C50H104N2O24

C50H104N2O24

atorvastatin
134523-00-5

atorvastatin

C116H170F2N6O32

C116H170F2N6O32

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 30℃; for 9h;91%
atorvastatin
134523-00-5

atorvastatin

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, calcium salt

[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, calcium salt

Conditions
ConditionsYield
With calcium hydroxide; water In methanol Product distribution / selectivity; Heating / reflux;88%
With calcium hydroxide; water In acetone at 20 - 25℃; for 50.0333h; Product distribution / selectivity;68%
With sodium hydroxide; calcium acetate In tert-butyl methyl ether; water; isopropyl alcohol for 24h; Product distribution / selectivity;
With sodium hydroxide; calcium chloride In water at 20 - 80℃; for 21.5h; Product distribution / selectivity;
atorvastatin
134523-00-5

atorvastatin

1-((3R,5R)-3,5-dihydroxy-7-(hydroxyamino)-7-oxoheptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-7H-pyrrole-3-carboxamide
1174332-81-0

1-((3R,5R)-3,5-dihydroxy-7-(hydroxyamino)-7-oxoheptyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-7H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With hydroxylamine In tetrahydrofuran; water at 20℃; for 1h;88%
3,6-dioxa-1,8-diaminooctane
929-59-9

3,6-dioxa-1,8-diaminooctane

atorvastatin
134523-00-5

atorvastatin

C72H82F2N6O10

C72H82F2N6O10

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 6h;88%
atorvastatin
134523-00-5

atorvastatin

PEODA13
361543-12-6

PEODA13

C92H122F2N6O20

C92H122F2N6O20

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 12h;88%
C21H19BrNO4(1+)*Br(1-)

C21H19BrNO4(1+)*Br(1-)

atorvastatin
134523-00-5

atorvastatin

C54H53FN3O9(1+)*Br(1-)

C54H53FN3O9(1+)*Br(1-)

Conditions
ConditionsYield
Stage #1: atorvastatin With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: C21H19BrNO4(1+)*Br(1-) In N,N-dimethyl-formamide at 70℃;
87%
1,14-diamino-3,6,9,12-tetraoxatetradecane
68960-97-4

1,14-diamino-3,6,9,12-tetraoxatetradecane

atorvastatin
134523-00-5

atorvastatin

C76H90F2N6O12

C76H90F2N6O12

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 35℃; for 12h;86%
calcium acetate
62-54-4

calcium acetate

atorvastatin
134523-00-5

atorvastatin

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
Stage #1: calcium acetate; atorvastatin In water; acetonitrile at 44℃; for 1.25h;
Stage #2: With sodium hydroxide In water at 30 - 70℃; for 9.5h; Product distribution / selectivity;
84.35%
D-lysine
923-27-3

D-lysine

atorvastatin
134523-00-5

atorvastatin

(3R,5R)-7-[3-phenyl-4-[(phenylamino)carbonyl]-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid D-lysine salt
609843-25-6

(3R,5R)-7-[3-phenyl-4-[(phenylamino)carbonyl]-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid D-lysine salt

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 20h;76%
atorvastatin
134523-00-5

atorvastatin

(3R,5R)-7-[3-phenyl-4-[(phenylamino)carbonyl]-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid DL-lysine salt
609843-24-5

(3R,5R)-7-[3-phenyl-4-[(phenylamino)carbonyl]-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid DL-lysine salt

Conditions
ConditionsYield
In ethyl acetate65%
L-ornithine
70-26-8

L-ornithine

atorvastatin
134523-00-5

atorvastatin

(3R,5R)-7-[3-phenyl-4-[(phenylamino)carbonyl]-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid L-ornithine salt

(3R,5R)-7-[3-phenyl-4-[(phenylamino)carbonyl]-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid L-ornithine salt

Conditions
ConditionsYield
In ethyl acetate47%
atorvastatin
134523-00-5

atorvastatin

atorvastatin lactone
125995-03-1

atorvastatin lactone

Conditions
ConditionsYield
In toluene at 60℃; for 40h;46%
hydrogenchloride In toluenen/a
In toluene for 4h; Product distribution / selectivity; Heating / reflux;
In hexane for 6h; Heating;3.9 g
2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

atorvastatin
134523-00-5

atorvastatin

2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid
581772-29-4

2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetone at 20℃; for 15h;46%
In dichloromethane at 20℃;
atorvastatin
134523-00-5

atorvastatin

FITC-PEG3-NH2

FITC-PEG3-NH2

1-((19R,21R)-1-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-ylamino)-19,21-dihydroxy-17-oxo-1-thioxo-6,9,12-trioxa-2,16-diazatricosan-23-yl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
1440755-31-6

1-((19R,21R)-1-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-ylamino)-19,21-dihydroxy-17-oxo-1-thioxo-6,9,12-trioxa-2,16-diazatricosan-23-yl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 36h;41%
1-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-3-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)thiourea
843660-59-3

1-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-3-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)thiourea

atorvastatin
134523-00-5

atorvastatin

1-((19R,21R)-1-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-ylamino)-19,21-dihydroxy-17-oxo-1-thioxo-6,9,12-trioxa-2,16-diazatricosan-23-yl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
1440755-31-6

1-((19R,21R)-1-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-ylamino)-19,21-dihydroxy-17-oxo-1-thioxo-6,9,12-trioxa-2,16-diazatricosan-23-yl)-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 36h;41%
methanol
67-56-1

methanol

atorvastatin
134523-00-5

atorvastatin

A

atorvastatin lactone
125995-03-1

atorvastatin lactone

B

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
345891-62-5

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With phosphoric acid In acetonitrile at 80℃; for 3h;A 15.2 mg
B 6.9 mg
atorvastatin
134523-00-5

atorvastatin

A

5-(4-Fluoro-phenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3-isopropyl-2-oxo-4-phenyl-2,3-dihydro-1H-pyrrole-3-carboxylic acid phenylamide

5-(4-Fluoro-phenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3-isopropyl-2-oxo-4-phenyl-2,3-dihydro-1H-pyrrole-3-carboxylic acid phenylamide

B

(3R,5R)-7-[3-(4-Fluoro-phenyl)-5-isopropyl-2-oxo-3-phenyl-4-phenylcarbamoyl-2,3-dihydro-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid

(3R,5R)-7-[3-(4-Fluoro-phenyl)-5-isopropyl-2-oxo-3-phenyl-4-phenylcarbamoyl-2,3-dihydro-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid

C

(3R,5R)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-2-oxo-4-phenyl-3-phenylcarbamoyl-2,3-dihydro-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid

(3R,5R)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-2-oxo-4-phenyl-3-phenylcarbamoyl-2,3-dihydro-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid

7-(9-fluoro-3-isopropyl-2-oxo-3-phenylcarbamoyl-2,3-dihydro-dibenzo[e,g]indol-1-yl)-3,5-dihydroxy-heptanoic acid

7-(9-fluoro-3-isopropyl-2-oxo-3-phenylcarbamoyl-2,3-dihydro-dibenzo[e,g]indol-1-yl)-3,5-dihydroxy-heptanoic acid

Conditions
ConditionsYield
In acetone for 14h; Irradiation;

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