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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Atorvastatin sodium

Cas:134523-01-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 134523-01-6 with best quality

Cas:134523-01-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 134523-01-6 ,Cardiovascular Agent Atorvastatin Sodium

Cas:134523-01-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr

Cardiovascular Agent Atorvastatin Sodium cas no 134523-01-6

Cas:134523-01-6

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

Atorvastatin sodium

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

ATORVASTATIN SODIUM CAS:134523-01-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

ATORVASTATIN SODIUM CAS:134523-01-6

Cas:134523-01-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Atorvastatin Calcium 134523-01-6

Cas:134523-01-6

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Atorvastatin sodium salt

Cas:134523-01-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Cardiovascular Agent Atorvastatin Sodium cas no 134523-01-6

Cas:134523-01-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply ATORVASTATIN SODIUM

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Other

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

ATORVASTATINSODIUM

Cas:134523-01-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Cardiovascular Agent Atorvastatin Sodium cas no 134523-01-6

Cas:134523-01-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Cardiovascular Agent Atorvastatin Sodium cas no 134523-01-6

Cas:134523-01-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Cardiovascular Agent Atorvastatin Sodium cas no 134523-01-6

Cas:134523-01-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/ATORVASTATIN SODIUM/SAGECHEM/Manufacturer in China

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:

ATORVASTATIN SODIUM

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Cardiovascular Agent Atorvastatin Sodium cas no 134523-01-6

Cas:134523-01-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

We produce carbomer by our own factory,carbomer 940 is our best seller.It is used for cosmetic and medical.And we also become agent for lubrizol.Our carbomer 940 get high viscosity and good transparency.The price will depond on the market,surely supp

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

TIANFUCHEM--134523-01-6---ATORVASTATIN SODIUM

Cas:134523-01-6

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

ATORVASTATIN SODIUM

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

ATORVASTATIN SODIUM

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

ATORVASTATIN SODIUM CAS 134523-01-6

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Other

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Atorvastatin Sodium

Cas:134523-01-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Hangzhou Dingyan Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in your re

Atorvastatin Sodium

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Atorvastatin Sodium

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

ATORVASTATIN SODIUM

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

ATORVASTATIN SODIUM

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Atorvastatin Sodium CAS No.134523-01-6

Cas:134523-01-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester
134395-00-9

(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
With sodium hydroxide; water In 1,4-dioxane; tert-butyl methyl ether for 21h; Product distribution / selectivity; Heating / reflux;97.7%
With methanol; sodium hydroxide; water In tert-butyl methyl ether for 21h; Product distribution / selectivity; Heating / reflux;91%
With sodium hydroxide; water; tert-butyl alcohol In tert-butyl methyl ether for 21h; Product distribution / selectivity; Heating / reflux;91%
ethyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
1146977-93-6

ethyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
With water; sodium hydroxide at 20℃; for 15h;89%
lipitor
134523-03-8

lipitor

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Stage #1: lipitor With hydrogenchloride In tetrahydrofuran; water at 20℃;
Stage #2: With sodium hydroxide In methanol; water Heating / reflux;
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2) NEt3 / 1) ethyl thiazolium catalyst / or with methyl thiazolium catalyst; 1) EtOH
2: 75 percent / pivalic acid / toluene; heptane; tetrahydrofuran / Heating
3: aq. HCl / methanol
4: aq. NaOH / methanol
View Scheme
tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
125971-86-0, 125995-13-3

tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 75 percent / pivalic acid / toluene; heptane; tetrahydrofuran / Heating
2: aq. HCl / methanol
3: aq. NaOH / methanol
View Scheme
Multi-step reaction with 3 steps
1: Acidic conditions
2: hydrogenchloride; methanol
3: sodium hydroxide / water
View Scheme
Multi-step reaction with 3 steps
1: Trimethylacetic acid / toluene / 1 h / 105 - 110 °C / Industrial scale
2: hydrogenchloride / methanol; water / 0 - 30 °C / Industrial scale
3: water; sodium hydroxide / methanol / 2.5 h / 0 - 30 °C / Industrial scale
View Scheme
Multi-step reaction with 3 steps
1: Trimethylacetic acid; diisopropylamine; tetra(n-butyl)ammonium hydrogensulfate / 40 h / 78 - 85 °C
2: hydrogenchloride; water / methanol / 25 - 30 °C
3: water; sodium hydroxide
View Scheme
2-((4R, 6R)-6-cyanomethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid tert-butyl ester
125971-94-0

2-((4R, 6R)-6-cyanomethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid tert-butyl ester

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / H2, ammonia / Molybdenum doped Raney nickel / methanol / 2585.7 Torr
2: 75 percent / pivalic acid / toluene; heptane; tetrahydrofuran / Heating
3: aq. HCl / methanol
4: aq. NaOH / methanol
View Scheme
Multi-step reaction with 4 steps
1: hydrogen; nickel; ammonia / methanol
2: Acidic conditions
3: hydrogenchloride; methanol
4: sodium hydroxide / water
View Scheme
Multi-step reaction with 4 steps
1: hydrogen; ammonia / cyclohexane; water / 30 - 40 °C / 3750.38 Torr / Autoclave
2: Trimethylacetic acid; diisopropylamine; tetra(n-butyl)ammonium hydrogensulfate / 40 h / 78 - 85 °C
3: hydrogenchloride; water / methanol / 25 - 30 °C
4: water; sodium hydroxide
View Scheme
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 75 percent / pivalic acid / toluene; heptane; tetrahydrofuran / Heating
2: aq. HCl / methanol
3: aq. NaOH / methanol
View Scheme
Multi-step reaction with 2 steps
1.1: Trimethylacetic acid / n-heptane / 100 °C
2.1: hydrogenchloride; water / methanol / 25 - 30 °C
2.2: -10 °C
View Scheme
Multi-step reaction with 3 steps
1: Trimethylacetic acid / toluene / 1 h / 105 - 110 °C / Industrial scale
2: hydrogenchloride / methanol; water / 0 - 30 °C / Industrial scale
3: water; sodium hydroxide / methanol / 2.5 h / 0 - 30 °C / Industrial scale
View Scheme
tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate
125971-95-1

tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. HCl / methanol
2: aq. NaOH / methanol
View Scheme
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydroxylamine hydrochloride In methanol; water; acetone at 55 - 65℃; Industry scale;
Stage #2: With sodium hydroxide In methanol; water at 35 - 45℃; Product distribution / selectivity;
Stage #1: tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride; water In tetrahydrofuran at 25℃; for 6.25h; Industry scale;
Stage #2: With sodium hydroxide In tetrahydrofuran at 31℃; for 14h; Product distribution / selectivity; Cooling;
[R(R*,R*)]-2-(4-fluorophenyl)-β,δ-di(tert-butyldimethylsiloxy)-5-(1-methylethyl)-3-phenyl-4-[(pheny)carbonyl]-1H-pyrrole-1-heptanoic acid test-butyl ester
697266-12-9

[R(R*,R*)]-2-(4-fluorophenyl)-β,δ-di(tert-butyldimethylsiloxy)-5-(1-methylethyl)-3-phenyl-4-[(pheny)carbonyl]-1H-pyrrole-1-heptanoic acid test-butyl ester

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 6h; Heating / reflux;
atorvastatin
134523-00-5

atorvastatin

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
With sodium hydroxide In water; acetonitrile at 20℃; for 144h;
With sodium hydroxide In water
With sodium hydroxide In water
(6-{2-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrolidin-1-yl]-ethyl}-2-phenyl-[1,3,2] dioxaborinan-4-yl)-acetic acid tert-butyl ester

(6-{2-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrolidin-1-yl]-ethyl}-2-phenyl-[1,3,2] dioxaborinan-4-yl)-acetic acid tert-butyl ester

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Stage #1: (6-{2-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrolidin-1-yl]-ethyl}-2-phenyl-[1,3,2] dioxaborinan-4-yl)-acetic acid tert-butyl ester In tetrahydrofuran for 0.5h;
Stage #2: With sodium hydroxide; water In tetrahydrofuran for 2 - 4h; Product distribution / selectivity; Heating / reflux;
C34H35FN2O3

C34H35FN2O3

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
With sodium hydroxide In methanol; water; acetone at 60℃; for 0.666667h; pH=12; Product distribution / selectivity;
With sodium hydroxide In water; isopropyl alcohol; acetone at 65℃; for 0.75h; pH=11.9; Product distribution / selectivity;
atorvastatin lactone
125995-03-1

atorvastatin lactone

(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester
134395-00-9

(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
With sodium hydroxide; water In methanol at 35 - 45℃; for 0.5 - 0.666667h; Product distribution / selectivity;
With sodium hydroxide; water In ethanol at 35 - 45℃; for 0.5 - 0.666667h; Product distribution / selectivity;
tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3,2-dioxaborinan-4-yl)acetate
849928-46-7

tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3,2-dioxaborinan-4-yl)acetate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
With water; sodium hydroxide In tetrahydrofuran at 20℃; for 3h;
With water; sodium hydroxide In tetrahydrofuran at 20℃; for 3h;
tert-butyl (4S,6S)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate
472967-95-6

tert-butyl (4S,6S)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Stage #1: tert-butyl (4S,6S)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate With hydrogenchloride In acetonitrile at 20℃;
Stage #2: With sodium hydroxide In water; acetonitrile at 20℃;
Stage #3: With hydrogenchloride In water; acetonitrile pH=9.0 - 9.5; Product distribution / selectivity;
Atorvastatin boronate

Atorvastatin boronate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 100℃; for 4h;
cis-t-butyl-7-nitro-3,5-dihydroxy-heptanoate
1370478-51-5

cis-t-butyl-7-nitro-3,5-dihydroxy-heptanoate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: methanesulfonic acid / tetrahydrofuran / 0 °C
2: hydrogen; ammonia / palladium 10% on activated carbon / water; tetrahydrofuran; methanol / 6 h / 20 °C
3: triethylamine / acetonitrile / 0 - 20 °C / Inert atmosphere
4: triethylamine / dichloromethane / 0 °C / Inert atmosphere
5: acetic anhydride / 5 h / 75 - 80 °C / Inert atmosphere
6: hydrogenchloride; water / methanol / 1.5 h / 20 °C
7: sodium hydroxide; water / methanol / 0 - 20 °C / pH 12
View Scheme
cis-t-butyl-2-methoxy-3,5-dioxane-6-amino-(N-ethyl-(4-fluorobenzene)-acetate)-heptanoate

cis-t-butyl-2-methoxy-3,5-dioxane-6-amino-(N-ethyl-(4-fluorobenzene)-acetate)-heptanoate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 0 °C / Inert atmosphere
2: acetic anhydride / 5 h / 75 - 80 °C / Inert atmosphere
3: hydrogenchloride; water / methanol / 1.5 h / 20 °C
4: sodium hydroxide; water / methanol / 0 - 20 °C / pH 12
View Scheme
cis-t-butyl-2-ethoxy-3,5-dioxane-6-amino(N,N-((4-fluorobenzene)isobutyryl)-acetic acid)-heptanoate

cis-t-butyl-2-ethoxy-3,5-dioxane-6-amino(N,N-((4-fluorobenzene)isobutyryl)-acetic acid)-heptanoate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic anhydride / 5 h / 75 - 80 °C / Inert atmosphere
2: hydrogenchloride; water / methanol / 1.5 h / 20 °C
3: sodium hydroxide; water / methanol / 0 - 20 °C / pH 12
View Scheme
cis-t-butyl-2-methoxy-3,5-dioxane-7-nitro-heptanoate

cis-t-butyl-2-methoxy-3,5-dioxane-7-nitro-heptanoate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: hydrogen; ammonia / palladium 10% on activated carbon / water; tetrahydrofuran; methanol / 6 h / 20 °C
2: triethylamine / acetonitrile / 0 - 20 °C / Inert atmosphere
3: triethylamine / dichloromethane / 0 °C / Inert atmosphere
4: acetic anhydride / 5 h / 75 - 80 °C / Inert atmosphere
5: hydrogenchloride; water / methanol / 1.5 h / 20 °C
6: sodium hydroxide; water / methanol / 0 - 20 °C / pH 12
View Scheme
cis-t-butyl-2-methoxy-3,5-dioxane-7-amino-heptanoate

cis-t-butyl-2-methoxy-3,5-dioxane-7-amino-heptanoate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / acetonitrile / 0 - 20 °C / Inert atmosphere
2: triethylamine / dichloromethane / 0 °C / Inert atmosphere
3: acetic anhydride / 5 h / 75 - 80 °C / Inert atmosphere
4: hydrogenchloride; water / methanol / 1.5 h / 20 °C
5: sodium hydroxide; water / methanol / 0 - 20 °C / pH 12
View Scheme
ethyl 7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-5-hydroxyhept-3-enoate

ethyl 7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-5-hydroxyhept-3-enoate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 20 °C
2: benzaldehyde; potassium tert-butylate / tetrahydrofuran / 1.75 h / -5 °C
3: hydrogenchloride / water; methanol; tetrahydrofuran / 3 h / 50 °C
4: sodium hydroxide; water / 15 h / 20 °C
View Scheme
ethyl 2-[6-{2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1Hpyrrol-1-yl]ethyl}-2-phenyl-1,3-dioxan-4-yl]acetate

ethyl 2-[6-{2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1Hpyrrol-1-yl]ethyl}-2-phenyl-1,3-dioxan-4-yl]acetate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hexane; isopropyl alcohol / 50 - 60 °C
2: hydrogenchloride / water; methanol; tetrahydrofuran / 3 h / 50 °C
3: sodium hydroxide; water / 15 h / 20 °C
View Scheme
C35H37FN2O4

C35H37FN2O4

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: benzaldehyde; potassium tert-butylate / tetrahydrofuran / 1.75 h / -5 °C
2: hydrogenchloride / water; methanol; tetrahydrofuran / 3 h / 50 °C
3: sodium hydroxide; water / 15 h / 20 °C
View Scheme
ethyl 2-[(2R,4R,6R)-6-{2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1Hpyrrol-1-yl]ethyl}-2-phenyl-1,3-dioxan-4-yl]acetate

ethyl 2-[(2R,4R,6R)-6-{2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1Hpyrrol-1-yl]ethyl}-2-phenyl-1,3-dioxan-4-yl]acetate

atorvastatin sodium
134523-01-6

atorvastatin sodium

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; methanol; tetrahydrofuran / 3 h / 50 °C
2: sodium hydroxide; water / 15 h / 20 °C
View Scheme
atorvastatin sodium
134523-01-6

atorvastatin sodium

atorvastatin
134523-00-5

atorvastatin

Conditions
ConditionsYield
With sodium hydroxide at 60 - 70℃; pH=12-13;95%
With hydrogenchloride In dichloromethane; water for 0.5h; Cooling with ice;94%
atorvastatin sodium
134523-01-6

atorvastatin sodium

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
With calcium acetate In water at 20℃; for 2h;93%
With calcium acetate In methanol; water at 60 - 65℃; for 2h; Industrial scale;85.4%
With calcium acetate In water at 13 - 63℃;
methanol
67-56-1

methanol

atorvastatin sodium
134523-01-6

atorvastatin sodium

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
345891-62-5

(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;88%
atorvastatin sodium
134523-01-6

atorvastatin sodium

hexan-1-ol
111-27-3

hexan-1-ol

hexyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

hexyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With sulfuric acid In dichloromethane at 0 - 20℃; for 2.58333h;70%
ethanol
64-17-5

ethanol

atorvastatin sodium
134523-01-6

atorvastatin sodium

ethyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
1146977-93-6

ethyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 2.58333h;68%
atorvastatin sodium
134523-01-6

atorvastatin sodium

butan-1-ol
71-36-3

butan-1-ol

butyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

butyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

Conditions
ConditionsYield
With sulfuric acid In dichloromethane at 0 - 20℃; for 2.58333h;59%
atorvastatin sodium
134523-01-6

atorvastatin sodium

{[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid} hemi-magnesium salt

{[R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid} hemi-magnesium salt

Conditions
ConditionsYield
With magnesium chloride In tert-butyl methyl ether; water for 1.41667h;
With hydrogenchloride; magnesium acetate In water; acetone at 25 - 45℃; for 73.5h; pH=8 - 8.5; Product distribution / selectivity;
atorvastatin sodium
134523-01-6

atorvastatin sodium

[R-(RS,RS)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid iron salt

[R-(RS,RS)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid iron salt

Conditions
ConditionsYield
With iron(II) sulfate In water at 40 - 45℃; for 1h; Product distribution / selectivity;
With iron(II) chloride In water at 40 - 45℃; for 2h; Product distribution / selectivity;
calcium acetate
62-54-4

calcium acetate

atorvastatin sodium
134523-01-6

atorvastatin sodium

lipitor
134523-03-8

lipitor

Conditions
ConditionsYield
In methanol; water at 13 - 63℃; Product distribution / selectivity;
atorvastatin sodium
134523-01-6

atorvastatin sodium

atorvastatin hemicalcium

atorvastatin hemicalcium

Conditions
ConditionsYield
With calcium chloride In water at 35 - 45℃; for 0.166667 - 0.5h; Product distribution / selectivity;
With calcium acetate In methanol; water at 50℃;
With calcium chloride In methanol; tert-butyl methyl ether; water at 25 - 30℃; pH=7.5 - 8.5; Product distribution / selectivity;

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