we are professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a R&D center in Hangzhou. I
Cas:163222-33-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:163222-33-1
Min.Order:1 Kilogram
FOB Price: $45.0 / 200.0
Type:Trading Company
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:163222-33-1
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquirySpecifications CAS No.: 190595-65-4 Other Names: Ezetimibe intermediates MF: C31H25F2NO3 EINECS No.: N/A
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Crystalline Powder Storage:-20°C Freezer Package:1kg/fo
Cas:163222-33-1
Min.Order:1 Kilogram
FOB Price: $10.0
Type:Trading Company
inquiry1 Factory price 2 High quality 3 Good service 4 Prompt service Appearance:powder Storage:Kept in dry and cool place and from sunlight; Kept the packing intact. Package: 25kg plastic woven bag with inner linning. Application:Is psychotropic dr
We are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical
Cas:163222-33-1
Min.Order:1 Gram
FOB Price: $10.0
Type:Manufacturers
inquiryEzetimibe CAS No.:163222-33-1 Name: Ezetimibe Synonyms: 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one
Cas:163222-33-1
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:163222-33-1
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c
Cas:163222-33-1
Min.Order:1 Kilogram
FOB Price: $12.0 / 13.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Ezetimibe The alias:Ezetimibe CAS NO:163222-33-1 Molecular formula:C24H21F2NO3 Molecular weight:409.4252 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security wit
Cas:163222-33-1
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryTIANFUCHEM--163222-33-1-- Ezetimibe in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationships
Cas:163222-33-1
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:163222-33-1
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:163222-33-1
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:163222-33-1
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryProduct Name: Ezetimibe Synonyms: (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; Ezetimibe
Cas:163222-33-1
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:163222-33-1
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:White crystalline powder Storage:Room temperature Package:1kg/bag Application:API Transportation:Express/Sea/Air Port:Any port in china
Cas:163222-33-1
Min.Order:100 Gram
FOB Price: $8.0
Type:Lab/Research institutions
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
Cas:163222-33-1
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
163222-33-1 On Sale 163222-33-1 Wholesaler Ezetimibe low price Product name Ezetimibe, cholesterol absorption inhibitor Description Potent selective cholesterol absorption inhibitor Alternative names Ezetrol SCH-58235
Cas:163222-33-1
Min.Order:100 Gram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:163222-33-1
Min.Order:10 Gram
FOB Price: $0.7
Type:Trading Company
inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA
Cas:163222-33-1
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At pres
Ezetimibe CAS:163222-33-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:163222-33-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:163222-33-1
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:163222-33-1
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiry(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone
ezetemibe
Conditions | Yield |
---|---|
With 10 wt% Pd(OH)2 on carbon; hydrogen In methanol; cyclohexane at 70℃; under 760.051 Torr; for 3h; | 99% |
With 5%-palladium/activated carbon; hydrogen In tetrahydrofuran; ethanol at 50 - 55℃; under 37.5038 - 75.0075 Torr; | 90.3% |
With palladium 10% on activated carbon; ammonium formate; acetic acid for 6h; Reflux; | 90% |
1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone hydrate
ezetemibe
Conditions | Yield |
---|---|
In n-heptane; tert-butyl methyl ether at 20℃; Product distribution / selectivity; Heating / reflux; | 99% |
In Isopropyl acetate at 20℃; Product distribution / selectivity; Heating / reflux; | |
With acetic acid at 20℃; Product distribution / selectivity; Heating / reflux; |
ezetemibe
Conditions | Yield |
---|---|
With sulfuric acid In water; isopropyl alcohol at 20 - 25℃; for 1h; | 95% |
With perchloric acid at 40℃; for 3h; Temperature; Solvent; | 92% |
With sulfuric acid In water; isopropyl alcohol at 20℃; for 1h; | 91.5% |
ezetemibe
Conditions | Yield |
---|---|
With pyridine hydrofluoride In tetrahydrofuran; pyridine at 20℃; for 24h; | 93% |
4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl pivalate
ezetemibe
Conditions | Yield |
---|---|
Stage #1: 4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl pivalate With sodium hydroxide In tetrahydrofuran; methanol at -15℃; Stage #2: With hydrogenchloride; water In ethyl acetate | 92% |
ezetemibe
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride In tert-butyl methyl ether at 20℃; for 0.25h; | 91% |
[14C]-Sch 57871
ezetemibe
Conditions | Yield |
---|---|
With dimethylsulfide borane complex; trifluoroacetic anhydride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In dichloromethane; toluene at -25 - -20℃; for 3h; Inert atmosphere; | 90% |
With glucose dehydrogenase; alpha-D-glucopyranose; NADP; KRED-128 In water; isopropyl alcohol at 35℃; for 1.5h; pH=7; Product distribution / selectivity; Phosphate buffer; | 89.26% |
With glucose dehydrogenase; potassium phosphate; alpha-D-glucopyranose; DL-dithiothreitol; NADP; magnesium sulfate; KRED-118 In methanol; water at 30℃; pH=7.0; Product distribution / selectivity; | 87.59% |
ezetemibe
Conditions | Yield |
---|---|
With hydrogen bromide In isopropyl alcohol at 20℃; for 4h; | 87% |
(3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)azetidin-2-one
ezetemibe
Conditions | Yield |
---|---|
With dihydrogen peroxide In acetic acid at 20℃; for 2h; Time; | 86.23% |
With dihydrogen peroxide In water; isopropyl alcohol at 20℃; for 0.5h; |
ezetemibe
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen; acetic acid In ethanol at 25℃; for 4h; pH=3; | 85.4% |
ezetemibe
Conditions | Yield |
---|---|
With hydrogen fluoride In ethanol at 0 - 10℃; Inert atmosphere; | 80.6% |
benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate
ezetemibe
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In methanol under 760.051 Torr; for 23h; Product distribution / selectivity; | 76% |
ezetemibe
Conditions | Yield |
---|---|
With trimethyl(benzyl)ammonium fluoride In propan-1-ol at 20 - 30℃; Inert atmosphere; | 75.1% |
ezetemibe
Conditions | Yield |
---|---|
Stage #1: C34H35F2NO3Si With sulfuric acid In isopropyl alcohol at 20℃; for 1h; Stage #2: With palladium 10% on activated carbon; hydrogen; ammonium formate In methanol for 2h; Inert atmosphere; | 75% |
C43H35F2NO3
ezetemibe
Conditions | Yield |
---|---|
With hydrogen; 3% Pd/C In methanol at 20℃; for 18h; Product distribution / selectivity; | 73.3% |
[14C]-Sch 57871
A
ezetemibe
B
(3R,4S)-1-(4-fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetidin-2-one
Conditions | Yield |
---|---|
With sodium tetrahydroborate; iodine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran; dichloromethane; toluene at -8 - 0℃; for 4h; Corey-Bakshi-Shibata Reduction; Inert atmosphere; stereoselective reaction; | A 55.4% B n/a |
With hydrogen; palladium 10% on activated carbon In ethanol under 3102.97 Torr; for 16h; | |
With Rhodococcus fascians MO22 cells at 35℃; pH=7; Microbiological reaction; aq. phosphate buffer; optical yield given as %de; diastereoselective reaction; |
(3R,4S)-4-(4-(trimethylsilyloxy)phenyl)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one
ezetemibe
Conditions | Yield |
---|---|
Stage #1: (3R,4S)-4-(4-(trimethylsilyloxy)phenyl)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one With methanesulfonic acid; dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran; methanol; toluene at -25 - 25℃; for 2.5 - 2.75h; Stage #2: With hydrogenchloride; water In tetrahydrofuran; methanol; toluene at 0℃; for 0.5h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With formic acid; triethylamine; (1S,2S)-N-methanesulfonyl-1,2-diphenylethane-1,2-diamine; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In tert-butyl methyl ether at 65℃; for 17h; Product distribution / selectivity; | A n/a B n/a |
With formic acid; triethylamine; dichloro(benzene)ruthenium(II) dimer; (1S,2S)-N-methanesulfonyl-1,2-diphenylethane-1,2-diamine In tert-butyl methyl ether at 65℃; for 17h; Product distribution / selectivity; | A n/a B n/a |
With formic acid; triethylamine; dichloro(mesitylene)ruthenium(II) dimer; N-((1S,2S)-2-amino-1,2-diphenylethyl)-1,1,1-trifluoromethanesulfonamide In tert-butyl methyl ether at 65℃; for 17h; Product distribution / selectivity; | A n/a B n/a |
(3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C 2: 79 percent / ammonium formate; HOAc / Pd-C / methanol / 3 h / 45 - 55 °C / pH 3 - 5 View Scheme | |
Multi-step reaction with 2 steps 1: BH3*Me2S / tetrahydrofuran / 3 h / 22 °C 2: H2 / 10percent Pd/C / ethanol / 16 h / 3102.9 Torr View Scheme | |
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / dichloromethane; tetrahydrofuran / 5 h / 0 °C 2: palladium on activated charcoal; hydrogen / methanol / 6 h / 20 °C / 3800.26 Torr View Scheme | |
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; dichloromethane / 5 h / 0 °C 2: palladium on activated charcoal; hydrogen / methanol / 6 h / 20 °C / 3800.26 Torr View Scheme | |
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / -10 °C / Inert atmosphere 2: palladium on activated charcoal; formic acid; ammonium formate / isopropyl alcohol / 3 h / 40 °C View Scheme |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C 2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C 3: BF3 etherate / toluene / 0.08 h / -30 °C 4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 5: 90 percent / hydrogen / 10 percent Pd/C / methanol; ethyl acetate / 3 h / 1551.44 Torr 6: 79 percent / bistrimethylsilylurea; BH3-Me2S / CH2Cl2 / 5 h / -20 - -15 °C View Scheme | |
Multi-step reaction with 7 steps 1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C 2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C 3: BF3 etherate / toluene / 0.08 h / -30 °C 4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 5: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr 6: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C 7: 79 percent / ammonium formate; HOAc / Pd-C / methanol / 3 h / 45 - 55 °C / pH 3 - 5 View Scheme | |
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 3 h / -5 °C 2: N,O-Bis(trimethylsilyl)acetamide; tetrabutyl ammonium fluoride / toluene / 48 h / Reflux 3: formic acid / dichloromethane / 12 h / Reflux 4: dimethyl sulfide borane / dichloromethane; toluene; tetrahydrofuran / 12 h / 15 °C 5: acetic acid; ammonium formate; palladium 10% on activated carbon / 6 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 5 h / -30 - -20 °C 2.1: tetrabutyl ammonium fluoride / toluene / 3 h / 60 °C 3.1: sulfuric acid / isopropyl alcohol / 1 h / 20 °C 3.2: 2 h / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride / toluene / 60 °C 2: dimethylsulfide borane complex / dichloromethane; toluene / 3 h / -5 - 0 °C / Inert atmosphere 3: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h View Scheme |
(2S,3S)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxazetidine-3-carbaldehyde
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: BF3 etherate / toluene / 0.08 h / -30 °C 2: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 3: 90 percent / hydrogen / 10 percent Pd/C / methanol; ethyl acetate / 3 h / 1551.44 Torr 4: 79 percent / bistrimethylsilylurea; BH3-Me2S / CH2Cl2 / 5 h / -20 - -15 °C View Scheme | |
Multi-step reaction with 5 steps 1: BF3 etherate / toluene / 0.08 h / -30 °C 2: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 3: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr 4: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C 5: 79 percent / ammonium formate; HOAc / Pd-C / methanol / 3 h / 45 - 55 °C / pH 3 - 5 View Scheme |
(3S,4S)-4-(4-Benzyloxy-phenyl)-3-((S)-1,2-dihydroxy-ethyl)-1-(4-fluoro-phenyl)-azetidin-2-one
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C 2: BF3 etherate / toluene / 0.08 h / -30 °C 3: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 4: 90 percent / hydrogen / 10 percent Pd/C / methanol; ethyl acetate / 3 h / 1551.44 Torr 5: 79 percent / bistrimethylsilylurea; BH3-Me2S / CH2Cl2 / 5 h / -20 - -15 °C View Scheme | |
Multi-step reaction with 6 steps 1: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C 2: BF3 etherate / toluene / 0.08 h / -30 °C 3: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 4: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr 5: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C 6: 79 percent / ammonium formate; HOAc / Pd-C / methanol / 3 h / 45 - 55 °C / pH 3 - 5 View Scheme |
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: BF3 etherate / toluene / 0.08 h / -30 °C 2: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 3: 90 percent / hydrogen / 10 percent Pd/C / methanol; ethyl acetate / 3 h / 1551.44 Torr 4: 79 percent / bistrimethylsilylurea; BH3-Me2S / CH2Cl2 / 5 h / -20 - -15 °C View Scheme | |
Multi-step reaction with 5 steps 1: BF3 etherate / toluene / 0.08 h / -30 °C 2: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 3: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr 4: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C 5: 79 percent / ammonium formate; HOAc / Pd-C / methanol / 3 h / 45 - 55 °C / pH 3 - 5 View Scheme |
(3R,4S)-4-(4-Benzyloxy-phenyl)-1-(4-fluoro-phenyl)-3-[(E)-3-(4-fluoro-phenyl)-3-oxo-propenyl]-azetidin-2-one
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / hydrogen / 10 percent Pd/C / methanol; ethyl acetate / 3 h / 1551.44 Torr 2: 79 percent / bistrimethylsilylurea; BH3-Me2S / CH2Cl2 / 5 h / -20 - -15 °C View Scheme | |
Multi-step reaction with 3 steps 1: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr 2: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C 3: 79 percent / ammonium formate; HOAc / Pd-C / methanol / 3 h / 45 - 55 °C / pH 3 - 5 View Scheme |
(3S,4S)-4-(4-Benzyloxy-phenyl)-1-(4-fluoro-phenyl)-3-[3-(4-fluoro-phenyl)-1-hydroxy-3-oxo-propyl]-azetidin-2-one
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 2: 90 percent / hydrogen / 10 percent Pd/C / methanol; ethyl acetate / 3 h / 1551.44 Torr 3: 79 percent / bistrimethylsilylurea; BH3-Me2S / CH2Cl2 / 5 h / -20 - -15 °C View Scheme | |
Multi-step reaction with 4 steps 1: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 2: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr 3: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C 4: 79 percent / ammonium formate; HOAc / Pd-C / methanol / 3 h / 45 - 55 °C / pH 3 - 5 View Scheme |
(Z)-1-(4-(benzyloxy)phenyl)-N-(4-fluorophenyl)methaneimine
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: (nBu)3N / heptane; toluene / 80 - 90 °C 2: LiOH*H2O / methanol / 2 h 3: oxalyl chloride / CH2Cl2 / 16 h / 22 °C 4: (Ph3P)4Pd / tetrahydrofuran / 1 h / 10 °C 5: BH3*Me2S / tetrahydrofuran / 3 h / 22 °C 6: H2 / 10percent Pd/C / ethanol / 16 h / 3102.9 Torr View Scheme |
(3R,4S)-1-(4-fluorophenyl)-3-(3-hydroxy-3-oxopropyl)-4-(4-benzyloxyphenyl)-2-azetidinone
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: oxalyl chloride / CH2Cl2 / 16 h / 22 °C 2: (Ph3P)4Pd / tetrahydrofuran / 1 h / 10 °C 3: BH3*Me2S / tetrahydrofuran / 3 h / 22 °C 4: H2 / 10percent Pd/C / ethanol / 16 h / 3102.9 Torr View Scheme |
3-((3R,4S)-1-(4-fluorophenyl)-2-oxo-4-(4-(benzyloxy)phenyl)azetidin-3-yl)propionic acid chloride
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: (Ph3P)4Pd / tetrahydrofuran / 1 h / 10 °C 2: BH3*Me2S / tetrahydrofuran / 3 h / 22 °C 3: H2 / 10percent Pd/C / ethanol / 16 h / 3102.9 Torr View Scheme |
methyl 3-((2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)propanoate
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: LiOH*H2O / methanol / 2 h 2: oxalyl chloride / CH2Cl2 / 16 h / 22 °C 3: (Ph3P)4Pd / tetrahydrofuran / 1 h / 10 °C 4: BH3*Me2S / tetrahydrofuran / 3 h / 22 °C 5: H2 / 10percent Pd/C / ethanol / 16 h / 3102.9 Torr View Scheme | |
Multi-step reaction with 4 steps 1.1: diethyl aluminiumcholoride / toluene / -12 - 20 °C / Inert atmosphere 2.1: magnesium / tetrahydrofuran / 1 h / 40 - 50 °C / Inert atmosphere 2.2: 1 h / -5 - 0 °C 3.1: [(S,S)-teth-TsDpen RuCl]; triethylamine; formic acid / ethylbenzene / 24 h / 35 - 40 °C / Inert atmosphere 4.1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran; ethanol / 50 - 55 °C / 37.5 - 75.01 Torr View Scheme |
acetic anhydride
ezetemibe
4(S)-(4-acetyloxyphenyl)-3(R)-(3(S)-acetyloxy-3-(4-fluorophenyl)propyl)-1-(4-fluorophenyl)-2-azetidinone
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane | 100% |
With dmap; triethylamine In dichloromethane at 20℃; for 2h; | 96% |
phenyl trifluoromethanesulfonamide
ezetemibe
(trifluoromethanesulfonyl)ezetimibe
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 3.5h; | 99% |
With dmap; triethylamine In dichloromethane at 20℃; for 3.5h; | 96% |
benzyl bromide
ezetemibe
(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 3h; | 99% |
acetic anhydride
ezetemibe
Acetic acid 4-{(2S,3R)-1-(4-fluoro-phenyl)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-4-oxo-azetidin-2-yl}-phenyl ester
Conditions | Yield |
---|---|
With sodium hydroxide In isopropyl alcohol for 5h; | 97% |
With sodium hydroxide In water; isopropyl alcohol for 5h; | 97% |
tert-butyldimethylsilyl chloride
ezetemibe
3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-fluoro-phenyl)-azetidin-2-one
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide for 5h; | 97% |
With 1H-imidazole In DMF (N,N-dimethyl-formamide) for 5h; | 97% |
N,N-phenylbistrifluoromethane-sulfonimide
ezetemibe
(trifluoromethanesulfonyl)ezetimibe
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 3.5h; | 96% |
With dmap; triethylamine In dichloromethane at 23℃; for 3h; | 95% |
With dmap; triethylamine In dichloromethane at 23℃; for 3h; | 95% |
With dmap; triethylamine In dichloromethane at 20℃; for 3h; Inert atmosphere; | 562.7 mg |
benzyl chloroformate
ezetemibe
benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; for 0.5h; | 92% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View