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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Manufacturer/High quality/Best price/In stock

Cas:70627-52-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Basic information Product Name: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Synonyms: 4-BENZYLOXYBENZYLIDENE-(4-FLUORO

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Fluoro-N-{[4-(phenylmethoxy)-phenyl]-methylene}-aniline

Cas:70627-52-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/870.html Product Name N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline CAS No.

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:1 Gram

FOB Price: $15.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 70627-52-0 with best quality

Cas:70627-52-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline CAS:70627-52-0

Cas:70627-52-0

Min.Order:1 Kilogram

FOB Price: $38.0 / 59.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline CAS:70627-52-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline CAS:70627-52-0

Cas:70627-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzenamine,4-fluoro-N-[[4-(phenylmethoxy)phenyl]methylene]-

Cas:70627-52-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-(4-Benzyloxybenzylidene) Fluoroaniline

Cas:70627-52-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance: White or off white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

CAS70627-52-0 N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:1 Kilogram

FOB Price: $10.0 / 30.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

ezetimibe intermediate 70627-52-0

Cas:70627-52-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

EZETIMIBE 163222-33-1 INTERMEDIATES

Cas:70627-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shangdong Shinning Pharm co.ltd

100% owned factory, regulatory compliance and be audited. Shandong Shining Pharm:Provincial chemical industry park(the first batch of certified park in Shandong Province), raw material and intermediate production base. Bromination, high pressure, hig

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Cas no.70627-52-0 99.5%+

Cas:70627-52-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzenamine,4-fluoro-N-[[4-(phenylmethoxy)phenyl]methylene]-

Cas:70627-52-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline CAS NO.70627-52-0

Cas:70627-52-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline CAS.70627-52-0;98% in stock,competitive priceAppearance:White to pale yellow plate crystals. Storage:Store in an airtight container, protected from light. Package:according to customers' requirements Appli

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

CAS70627-52-0 N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4'-(Benzyloxy)benzylidene-4-fluoroaniline >

Cas:70627-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Synonyms: 4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE;4-(4-Benzyloxybenzylidene)Fluoroaniline;N-(4-(benzyloxy)benzylidene)-4-fluorobenzenamine;4-Fluoro-N-[[4-(phenylmethoxy)phenyl]methylen

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

CAS70627-52-0 N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: N-(4-(Benzyloxy)benzylidene)-4-Fluoroaniline CAS No.:70627-52-0 Molecule Formula:C20H16FNO Molecule Weight:305.35 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

High Quality N-(4-(Benzyloxy)benzylidene)-4-Fluoroaniline

Cas:70627-52-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Cas:70627-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

p-benzyloxybenzaldehyde
4397-53-9

p-benzyloxybenzaldehyde

4-fluoroaniline
371-40-4

4-fluoroaniline

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

Conditions
ConditionsYield
In isopropyl alcohol at 40℃;95%
In toluene Reflux; Large scale;93.6%
In toluene for 48h; Heating;75%
With magnesium sulfate In dichloromethane at 20℃; for 2h;
benzyl bromide
100-39-0

benzyl bromide

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

4-fluoroaniline
371-40-4

4-fluoroaniline

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

Conditions
ConditionsYield
Stage #1: benzyl bromide; 4-hydroxy-benzaldehyde With potassium carbonate at 20℃; for 12h;
Stage #2: 4-fluoroaniline In acetone for 4h; Reflux;
92%
Stage #1: 4-hydroxy-benzaldehyde With sodium hydroxide; tetrabutylammomium bromide In dichloromethane; water at 20℃; for 0.25h;
Stage #2: benzyl bromide In dichloromethane; water at 25 - 30℃; for 1.5h;
Stage #3: 4-fluoroaniline In isopropyl alcohol at 20 - 60℃; for 2.5h;
Reaxys ID: 30143016

Reaxys ID: 30143016

(S)-4-phenyl-2-oxazolidinone
99395-88-7

(S)-4-phenyl-2-oxazolidinone

A

Reaxys ID: 30143012

Reaxys ID: 30143012

B

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: isopropyl alcohol / 40 °C
View Scheme
benzyl chloride
100-44-7

benzyl chloride

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: isopropyl alcohol / 40 °C
View Scheme
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

benzyl chloride
100-44-7

benzyl chloride

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;20.3 g
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

C40H36F2N2O5
1185883-39-9

C40H36F2N2O5

Conditions
ConditionsYield
Stage #1: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine; (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one With N-ethyl-N,N-diisopropylamine In dichloromethane at -5℃; for 2h; Inert atmosphere;
Stage #2: With titanium tetrachloride In dichloromethane at -30℃; for 2h; Inert atmosphere;
94%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

C43H44F2N2O5Si

C43H44F2N2O5Si

Conditions
ConditionsYield
Stage #1: chloro-trimethyl-silane; 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine; (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one With N-ethyl-N,N-diisopropylamine In dichloromethane at -5 - 5℃; Inert atmosphere;
Stage #2: With titanium tetrachloride In dichloromethane at -5 - 5℃; for 1h;
93%
(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one
942485-56-5

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

(3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one
190595-65-4

(3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one

Conditions
ConditionsYield
With N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride In toluene at 60℃;88.94%
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

N-(4-(benzyloxy)benzyl)-4-fluoroaniline
415960-63-3

N-(4-(benzyloxy)benzyl)-4-fluoroaniline

Conditions
ConditionsYield
With 4-Fluorothiophenol In toluene for 8h; Sealed tube; Irradiation;85%
3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4S)-phenyl-1,3-oxazolidin-2-one
953805-20-4

3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4S)-phenyl-1,3-oxazolidin-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

3-{(2R,3S)-3-[(4-fluorophenyl)amino]-2-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-3-[4-(benzyloxy)phenyI]propanoyl}-(4S)-4-phenyl-1,3-oxazolidin-2-one
953805-22-6

3-{(2R,3S)-3-[(4-fluorophenyl)amino]-2-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-3-[4-(benzyloxy)phenyI]propanoyl}-(4S)-4-phenyl-1,3-oxazolidin-2-one

Conditions
ConditionsYield
With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane at -5℃; for 3h;78%
ethyl 3-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]propanoate

ethyl 3-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]propanoate

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

ethyl-3-(4-(benzyloxy)benzyl)-3-((4-fluorophenyl)amino)-2-((S)-2-oxo-4-phenyloxazolidin-3-carbonyl)propanoate

ethyl-3-(4-(benzyloxy)benzyl)-3-((4-fluorophenyl)amino)-2-((S)-2-oxo-4-phenyloxazolidin-3-carbonyl)propanoate

Conditions
ConditionsYield
Stage #1: ethyl 3-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]propanoate; 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine With N-ethyl-N,N-diisopropylamine In dichloromethane at -30℃; for 0.166667h; Inert atmosphere;
Stage #2: With titanium tetrachloride In dichloromethane at -30 - -20℃; for 3h;
76%
(-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one
793673-93-5

(-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

trans-1-(4-fluorophenyl)-3-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone

trans-1-(4-fluorophenyl)-3-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone

Conditions
ConditionsYield
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -50℃; for 0.5h;
Stage #2: (-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one at -50℃; for 0.25h;
Stage #3: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In tetrahydrofuran; DMF (N,N-dimethyl-formamide); hexane at -50℃; for 1h;
67%
(-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one
793673-93-5

(-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

C31H27F2NO3

C31H27F2NO3

Conditions
ConditionsYield
Stage #1: (-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -50℃; for 0.916667h;
Stage #2: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine In tetrahydrofuran at -50℃; for 2.5h; Reagent/catalyst;
67%
(3S)-hydroxy-γ-butyrolactone
5469-16-9, 58081-05-3, 131432-37-6, 7331-52-4

(3S)-hydroxy-γ-butyrolactone

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

A

(3S,4S)-4-(4-Benzyloxy-phenyl)-3-((S)-1,2-dihydroxy-ethyl)-1-(4-fluoro-phenyl)-azetidin-2-one
221349-56-0

(3S,4S)-4-(4-Benzyloxy-phenyl)-3-((S)-1,2-dihydroxy-ethyl)-1-(4-fluoro-phenyl)-azetidin-2-one

B

(3S,4R)-4-(4-Benzyloxy-phenyl)-3-((S)-1,2-dihydroxy-ethyl)-1-(4-fluoro-phenyl)-azetidin-2-one

(3S,4R)-4-(4-Benzyloxy-phenyl)-3-((S)-1,2-dihydroxy-ethyl)-1-(4-fluoro-phenyl)-azetidin-2-one

Conditions
ConditionsYield
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium chloride; lithium diisopropyl amide In tetrahydrofuran; N,N-dimethyl-formamide at -30 - -25℃; for 18h; Cycloaddition;A 64%
B n/a
(4S)-N-acetyl-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one
1375257-24-1

(4S)-N-acetyl-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

(R)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)azetidin-2-one

(R)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)azetidin-2-one

Conditions
ConditionsYield
Stage #1: N-acetyl-(S)-4-isopropyl-1-[(R)-1-phenylethyl] imidazolidin-2-one With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h; Mannich Aminomethylation; Inert atmosphere;
Stage #2: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine In tetrahydrofuran at -78 - 0℃; Mannich Aminomethylation; Inert atmosphere; stereoselective reaction;
63%
(S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one
1185883-41-3

(S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

C42H40F2N2O6

C42H40F2N2O6

Conditions
ConditionsYield
With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane at -50℃; for 3.66667h; Inert atmosphere;62.5%
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

C40H36F2N2O5

C40H36F2N2O5

Conditions
ConditionsYield
With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane at -30 - -20℃; for 5h;60.9%
(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one
942485-56-5

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

(S)-3-{(R)-2-[(S)-[4-(benzyloxy)phenyl][(4-fluorophenyl)amino]methyl]-4-[2-(4-fluorophenyl)[1,3]dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one
954109-20-7

(S)-3-{(R)-2-[(S)-[4-(benzyloxy)phenyl][(4-fluorophenyl)amino]methyl]-4-[2-(4-fluorophenyl)[1,3]dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: (S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one With titanium(IV) isopropylate; titanium tetrachloride In dichloromethane at 0℃; for 0.666667h;
Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h;
Stage #3: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine Product distribution / selectivity;
58%
5-(4-fluorophenyl)pentanoyl chloride
204589-92-4

5-(4-fluorophenyl)pentanoyl chloride

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-2-azetidinone

4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-2-azetidinone

Conditions
ConditionsYield
With tributyl-amine In toluene for 72h; Heating;48%
1-(5-methoxy-1,5-dioxopentyl)-4(S)-phenyloxazolidin-2-one
477558-79-5

1-(5-methoxy-1,5-dioxopentyl)-4(S)-phenyloxazolidin-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

3-[2-(3-methoxy-3-oxopropyl)-3-(4-fluorophenylamino)-3-(4-benzyloxyphenyl)-1-oxopropyl]-4(S)-phenyloxazolidin-2-one
934245-17-7

3-[2-(3-methoxy-3-oxopropyl)-3-(4-fluorophenylamino)-3-(4-benzyloxyphenyl)-1-oxopropyl]-4(S)-phenyloxazolidin-2-one

Conditions
ConditionsYield
Stage #1: 1-(5-methoxy-1,5-dioxopentyl)-4(S)-phenyloxazolidin-2-one With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane at -10℃; for 1h;
Stage #2: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine In dichloromethane at -10℃; for 6h; optical yield given as %de;
48%
Stage #1: 1-(5-methoxy-1,5-dioxopentyl)-4(S)-phenyloxazolidin-2-one With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h;
Stage #2: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine In dichloromethane at -20℃; for 4h;
Stage #3: With acetic acid In dichloromethane at -20 - 0℃;
5,6-dihydro-pyran-2-one
3393-45-1

5,6-dihydro-pyran-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

anti-3-(3-hydroxypropyl)-1-(4-methoxyphenyl)-4-phenylazetidin-2-one

anti-3-(3-hydroxypropyl)-1-(4-methoxyphenyl)-4-phenylazetidin-2-one

Conditions
ConditionsYield
Stage #1: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine With chloro(1,5-cyclooctadiene)rhodium(I) dimer; boron trifluoride diethyl etherate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Schlenk technique;
Stage #2: 5,6-dihydro-pyran-2-one With diethylzinc In tetrahydrofuran; hexane at 20℃; for 24h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; Schlenk technique;
46%
5,6-dihydro-pyran-2-one
3393-45-1

5,6-dihydro-pyran-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

C26H26FNO2

C26H26FNO2

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; diethylzinc; aluminum isopropoxide In tetrahydrofuran at 20℃; for 24h; Catalytic behavior; Temperature; Solvent; Reagent/catalyst; Inert atmosphere; Schlenk technique;9%
pent-4-enoic acid
591-80-0

pent-4-enoic acid

4-fluoro-1-iodobenzene
352-34-1

4-fluoro-1-iodobenzene

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-1-E-propenyl)-4-(4-benzyloxyphenyl)-2-azetidinone

1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-1-E-propenyl)-4-(4-benzyloxyphenyl)-2-azetidinone

1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-2-E-propenyl)-4-(4-benzyloxyphenyl)-2-azetidinone

1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-2-E-propenyl)-4-(4-benzyloxyphenyl)-2-azetidinone

Conditions
ConditionsYield
Stage #1: pent-4-enoic acid; 4-fluoro-1-iodobenzene With tetrabutyl-ammonium chloride; potassium acetate; triphenylphosphine; palladium diacetate In N,N-dimethyl-formamide at 80℃; Arylation;
Stage #2: With oxalyl dichloride In dichloromethane at 22℃; for 1h; Substitution;
Stage #3: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine With tributyl-amine In n-heptane; toluene at 80℃; for 18h; cyclocondensation; Staudinger conditions;
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone

1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 48 percent / tributylamine / toluene / 72 h / Heating
2: 63 percent / ammonium formate / 10 percent Pd/C / methanol / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: PPh3; KOAc; n-Bu4NCl / Pd(OAc)2 / dimethylformamide / 80 °C
1.2: oxalyl chloride / CH2Cl2 / 1 h / 22 °C
1.3: NBu3 / toluene; heptane / 18 h / 80 °C
2.1: 68 percent / BCl3*SMe2 / CH2Cl2 / 18 h / 20 °C
3.1: H2 / 10 percent Pd/C / ethyl acetate / 2 h / 760 Torr
View Scheme
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

N-(4-fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide

N-(4-fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 48 percent / tributylamine / toluene / 72 h / Heating
2: 20 percent / ammonium formate / 10 percent Pd/C / methanol / Heating
View Scheme
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-2-E-propenyl]-4-(4-hydroxyphenyl)-2-azetidinone

1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-2-E-propenyl]-4-(4-hydroxyphenyl)-2-azetidinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: PPh3; KOAc; n-Bu4NCl / Pd(OAc)2 / dimethylformamide / 80 °C
1.2: oxalyl chloride / CH2Cl2 / 1 h / 22 °C
1.3: NBu3 / toluene; heptane / 18 h / 80 °C
2.1: 68 percent / BCl3*SMe2 / CH2Cl2 / 18 h / 20 °C
View Scheme
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-2-azetidinone

4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-2-azetidinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: PPh3; KOAc; n-Bu4NCl / Pd(OAc)2 / dimethylformamide / 80 °C
1.2: oxalyl chloride / CH2Cl2 / 1 h / 22 °C
1.3: NBu3 / toluene; heptane / 18 h / 80 °C
2.1: H2 / 10 percent Pd/C / ethyl acetate / 2 h / 760 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: PPh3; KOAc; n-Bu4NCl / Pd(OAc)2 / dimethylformamide / 80 °C
1.2: oxalyl chloride / CH2Cl2 / 1 h / 22 °C
1.3: NBu3 / toluene; heptane / 18 h / 80 °C
2.1: H2 / 10 percent Pd/C / ethyl acetate / 2 h / 760 Torr
View Scheme
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

[14C]-Sch 57871
191330-56-0

[14C]-Sch 57871

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C
2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C
3: BF3 etherate / toluene / 0.08 h / -30 °C
4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C
5: 90 percent / hydrogen / 10 percent Pd/C / methanol; ethyl acetate / 3 h / 1551.44 Torr
View Scheme
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

(3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one
190595-65-4

(3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C
2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C
3: BF3 etherate / toluene / 0.08 h / -30 °C
4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C
5: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 3 h / -5 °C
2: N,O-Bis(trimethylsilyl)acetamide; tetrabutyl ammonium fluoride / toluene / 48 h / Reflux
3: formic acid / dichloromethane / 12 h / Reflux
View Scheme
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

ezetemibe
163222-33-1

ezetemibe

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C
2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C
3: BF3 etherate / toluene / 0.08 h / -30 °C
4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C
5: 90 percent / hydrogen / 10 percent Pd/C / methanol; ethyl acetate / 3 h / 1551.44 Torr
6: 79 percent / bistrimethylsilylurea; BH3-Me2S / CH2Cl2 / 5 h / -20 - -15 °C
View Scheme
Multi-step reaction with 7 steps
1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C
2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C
3: BF3 etherate / toluene / 0.08 h / -30 °C
4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C
5: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr
6: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C
7: 79 percent / ammonium formate; HOAc / Pd-C / methanol / 3 h / 45 - 55 °C / pH 3 - 5
View Scheme
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 3 h / -5 °C
2: N,O-Bis(trimethylsilyl)acetamide; tetrabutyl ammonium fluoride / toluene / 48 h / Reflux
3: formic acid / dichloromethane / 12 h / Reflux
4: dimethyl sulfide borane / dichloromethane; toluene; tetrahydrofuran / 12 h / 15 °C
5: acetic acid; ammonium formate; palladium 10% on activated carbon / 6 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 5 h / -30 - -20 °C
2.1: tetrabutyl ammonium fluoride / toluene / 3 h / 60 °C
3.1: sulfuric acid / isopropyl alcohol / 1 h / 20 °C
3.2: 2 h / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride / toluene / 60 °C
2: dimethylsulfide borane complex / dichloromethane; toluene / 3 h / -5 - 0 °C / Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h
View Scheme
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone
163222-32-0

(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C
2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C
3: BF3 etherate / toluene / 0.08 h / -30 °C
4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C
5: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr
6: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C
View Scheme
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 3 h / -5 °C
2: N,O-Bis(trimethylsilyl)acetamide; tetrabutyl ammonium fluoride / toluene / 48 h / Reflux
3: formic acid / dichloromethane / 12 h / Reflux
4: dimethyl sulfide borane / dichloromethane; toluene; tetrahydrofuran / 12 h / 15 °C
View Scheme
Multi-step reaction with 2 steps
1: N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride / toluene / 60 °C
2: dimethylsulfide borane complex / dichloromethane; toluene / 3 h / -5 - 0 °C / Inert atmosphere
View Scheme
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

(2S,3S)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxazetidine-3-carbaldehyde
221349-58-2

(2S,3S)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxazetidine-3-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C
2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / -30 °C / Inert atmosphere
1.2: 3 h / -30 - -20 °C
2.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 3 h / 50 °C
2.2: 2 h / Reflux
3.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / -45 - 20 °C
View Scheme
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
70627-52-0

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

(3R,4S)-4-(4-Benzyloxy-phenyl)-1-(4-fluoro-phenyl)-3-[(E)-3-(4-fluoro-phenyl)-3-oxo-propenyl]-azetidin-2-one
221349-60-6

(3R,4S)-4-(4-Benzyloxy-phenyl)-1-(4-fluoro-phenyl)-3-[(E)-3-(4-fluoro-phenyl)-3-oxo-propenyl]-azetidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C
2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C
3: BF3 etherate / toluene / 0.08 h / -30 °C
4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C
View Scheme

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