Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:70627-52-0
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryN-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Basic information Product Name: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Synonyms: 4-BENZYLOXYBENZYLIDENE-(4-FLUORO
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:70627-52-0
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/870.html Product Name N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline CAS No.
Cas:70627-52-0
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:70627-52-0
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:70627-52-0
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inquiryN-(4-(Benzyloxy)benzylidene)-4-fluoroaniline CAS:70627-52-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryAppearance: White or off white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:
Cas:70627-52-0
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inquiryOur advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
Cas:70627-52-0
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:70627-52-0
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:70627-52-0
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:70627-52-0
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inquiry100% owned factory, regulatory compliance and be audited. Shandong Shining Pharm:Provincial chemical industry park(the first batch of certified park in Shandong Province), raw material and intermediate production base. Bromination, high pressure, hig
Cas:70627-52-0
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inquiryWe are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co
Cas:70627-52-0
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:70627-52-0
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:70627-52-0
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:70627-52-0
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inquiryN-(4-(Benzyloxy)benzylidene)-4-fluoroaniline CAS.70627-52-0;98% in stock,competitive priceAppearance:White to pale yellow plate crystals. Storage:Store in an airtight container, protected from light. Package:according to customers' requirements Appli
Cas:70627-52-0
Min.Order:1 Gram
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o
Cas:70627-52-0
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:70627-52-0
Min.Order:1 Gram
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:70627-52-0
Min.Order:1 Milligram
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inquiryProduct Name: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Synonyms: 4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE;4-(4-Benzyloxybenzylidene)Fluoroaniline;N-(4-(benzyloxy)benzylidene)-4-fluorobenzenamine;4-Fluoro-N-[[4-(phenylmethoxy)phenyl]methylen
Cas:70627-52-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:70627-52-0
Min.Order:1 Kilogram
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inquiryProduct name: N-(4-(Benzyloxy)benzylidene)-4-Fluoroaniline CAS No.:70627-52-0 Molecule Formula:C20H16FNO Molecule Weight:305.35 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard
Cas:70627-52-0
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:70627-52-0
Min.Order:1 Kilogram
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:70627-52-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryp-benzyloxybenzaldehyde
4-fluoroaniline
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
In isopropyl alcohol at 40℃; | 95% |
In toluene Reflux; Large scale; | 93.6% |
In toluene for 48h; Heating; | 75% |
With magnesium sulfate In dichloromethane at 20℃; for 2h; |
benzyl bromide
4-hydroxy-benzaldehyde
4-fluoroaniline
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Stage #1: benzyl bromide; 4-hydroxy-benzaldehyde With potassium carbonate at 20℃; for 12h; Stage #2: 4-fluoroaniline In acetone for 4h; Reflux; | 92% |
Stage #1: 4-hydroxy-benzaldehyde With sodium hydroxide; tetrabutylammomium bromide In dichloromethane; water at 20℃; for 0.25h; Stage #2: benzyl bromide In dichloromethane; water at 25 - 30℃; for 1.5h; Stage #3: 4-fluoroaniline In isopropyl alcohol at 20 - 60℃; for 2.5h; |
(S)-4-phenyl-2-oxazolidinone
B
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
4-hydroxy-benzaldehyde
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: isopropyl alcohol / 40 °C View Scheme |
benzyl chloride
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: isopropyl alcohol / 40 °C View Scheme |
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
benzyl chloride
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h; | 20.3 g |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
C40H36F2N2O5
Conditions | Yield |
---|---|
Stage #1: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine; (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one With N-ethyl-N,N-diisopropylamine In dichloromethane at -5℃; for 2h; Inert atmosphere; Stage #2: With titanium tetrachloride In dichloromethane at -30℃; for 2h; Inert atmosphere; | 94% |
chloro-trimethyl-silane
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
Conditions | Yield |
---|---|
Stage #1: chloro-trimethyl-silane; 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine; (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one With N-ethyl-N,N-diisopropylamine In dichloromethane at -5 - 5℃; Inert atmosphere; Stage #2: With titanium tetrachloride In dichloromethane at -5 - 5℃; for 1h; | 93% |
(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
(3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride In toluene at 60℃; | 88.94% |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
N-(4-(benzyloxy)benzyl)-4-fluoroaniline
Conditions | Yield |
---|---|
With 4-Fluorothiophenol In toluene for 8h; Sealed tube; Irradiation; | 85% |
3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4S)-phenyl-1,3-oxazolidin-2-one
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
3-{(2R,3S)-3-[(4-fluorophenyl)amino]-2-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-3-[4-(benzyloxy)phenyI]propanoyl}-(4S)-4-phenyl-1,3-oxazolidin-2-one
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane at -5℃; for 3h; | 78% |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Stage #1: ethyl 3-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]propanoate; 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine With N-ethyl-N,N-diisopropylamine In dichloromethane at -30℃; for 0.166667h; Inert atmosphere; Stage #2: With titanium tetrachloride In dichloromethane at -30 - -20℃; for 3h; | 76% |
(-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -50℃; for 0.5h; Stage #2: (-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one at -50℃; for 0.25h; Stage #3: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In tetrahydrofuran; DMF (N,N-dimethyl-formamide); hexane at -50℃; for 1h; | 67% |
(-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Stage #1: (-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -50℃; for 0.916667h; Stage #2: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine In tetrahydrofuran at -50℃; for 2.5h; Reagent/catalyst; | 67% |
(3S)-hydroxy-γ-butyrolactone
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
A
(3S,4S)-4-(4-Benzyloxy-phenyl)-3-((S)-1,2-dihydroxy-ethyl)-1-(4-fluoro-phenyl)-azetidin-2-one
Conditions | Yield |
---|---|
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium chloride; lithium diisopropyl amide In tetrahydrofuran; N,N-dimethyl-formamide at -30 - -25℃; for 18h; Cycloaddition; | A 64% B n/a |
(4S)-N-acetyl-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Stage #1: N-acetyl-(S)-4-isopropyl-1-[(R)-1-phenylethyl] imidazolidin-2-one With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h; Mannich Aminomethylation; Inert atmosphere; Stage #2: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine In tetrahydrofuran at -78 - 0℃; Mannich Aminomethylation; Inert atmosphere; stereoselective reaction; | 63% |
(S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane at -50℃; for 3.66667h; Inert atmosphere; | 62.5% |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
Conditions | Yield |
---|---|
With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane at -30 - -20℃; for 5h; | 60.9% |
(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
(S)-3-{(R)-2-[(S)-[4-(benzyloxy)phenyl][(4-fluorophenyl)amino]methyl]-4-[2-(4-fluorophenyl)[1,3]dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: (S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one With titanium(IV) isopropylate; titanium tetrachloride In dichloromethane at 0℃; for 0.666667h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h; Stage #3: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine Product distribution / selectivity; | 58% |
5-(4-fluorophenyl)pentanoyl chloride
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
With tributyl-amine In toluene for 72h; Heating; | 48% |
1-(5-methoxy-1,5-dioxopentyl)-4(S)-phenyloxazolidin-2-one
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
3-[2-(3-methoxy-3-oxopropyl)-3-(4-fluorophenylamino)-3-(4-benzyloxyphenyl)-1-oxopropyl]-4(S)-phenyloxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 1-(5-methoxy-1,5-dioxopentyl)-4(S)-phenyloxazolidin-2-one With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane at -10℃; for 1h; Stage #2: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine In dichloromethane at -10℃; for 6h; optical yield given as %de; | 48% |
Stage #1: 1-(5-methoxy-1,5-dioxopentyl)-4(S)-phenyloxazolidin-2-one With titanium(IV) isopropylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h; Stage #2: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine In dichloromethane at -20℃; for 4h; Stage #3: With acetic acid In dichloromethane at -20 - 0℃; |
5,6-dihydro-pyran-2-one
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Stage #1: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine With chloro(1,5-cyclooctadiene)rhodium(I) dimer; boron trifluoride diethyl etherate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Schlenk technique; Stage #2: 5,6-dihydro-pyran-2-one With diethylzinc In tetrahydrofuran; hexane at 20℃; for 24h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; Schlenk technique; | 46% |
5,6-dihydro-pyran-2-one
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; diethylzinc; aluminum isopropoxide In tetrahydrofuran at 20℃; for 24h; Catalytic behavior; Temperature; Solvent; Reagent/catalyst; Inert atmosphere; Schlenk technique; | 9% |
pent-4-enoic acid
4-fluoro-1-iodobenzene
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Stage #1: pent-4-enoic acid; 4-fluoro-1-iodobenzene With tetrabutyl-ammonium chloride; potassium acetate; triphenylphosphine; palladium diacetate In N,N-dimethyl-formamide at 80℃; Arylation; Stage #2: With oxalyl dichloride In dichloromethane at 22℃; for 1h; Substitution; Stage #3: 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine With tributyl-amine In n-heptane; toluene at 80℃; for 18h; cyclocondensation; Staudinger conditions; |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 48 percent / tributylamine / toluene / 72 h / Heating 2: 63 percent / ammonium formate / 10 percent Pd/C / methanol / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: PPh3; KOAc; n-Bu4NCl / Pd(OAc)2 / dimethylformamide / 80 °C 1.2: oxalyl chloride / CH2Cl2 / 1 h / 22 °C 1.3: NBu3 / toluene; heptane / 18 h / 80 °C 2.1: 68 percent / BCl3*SMe2 / CH2Cl2 / 18 h / 20 °C 3.1: H2 / 10 percent Pd/C / ethyl acetate / 2 h / 760 Torr View Scheme |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 48 percent / tributylamine / toluene / 72 h / Heating 2: 20 percent / ammonium formate / 10 percent Pd/C / methanol / Heating View Scheme |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: PPh3; KOAc; n-Bu4NCl / Pd(OAc)2 / dimethylformamide / 80 °C 1.2: oxalyl chloride / CH2Cl2 / 1 h / 22 °C 1.3: NBu3 / toluene; heptane / 18 h / 80 °C 2.1: 68 percent / BCl3*SMe2 / CH2Cl2 / 18 h / 20 °C View Scheme |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: PPh3; KOAc; n-Bu4NCl / Pd(OAc)2 / dimethylformamide / 80 °C 1.2: oxalyl chloride / CH2Cl2 / 1 h / 22 °C 1.3: NBu3 / toluene; heptane / 18 h / 80 °C 2.1: H2 / 10 percent Pd/C / ethyl acetate / 2 h / 760 Torr View Scheme | |
Multi-step reaction with 2 steps 1.1: PPh3; KOAc; n-Bu4NCl / Pd(OAc)2 / dimethylformamide / 80 °C 1.2: oxalyl chloride / CH2Cl2 / 1 h / 22 °C 1.3: NBu3 / toluene; heptane / 18 h / 80 °C 2.1: H2 / 10 percent Pd/C / ethyl acetate / 2 h / 760 Torr View Scheme |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
[14C]-Sch 57871
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C 2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C 3: BF3 etherate / toluene / 0.08 h / -30 °C 4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 5: 90 percent / hydrogen / 10 percent Pd/C / methanol; ethyl acetate / 3 h / 1551.44 Torr View Scheme |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
(3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C 2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C 3: BF3 etherate / toluene / 0.08 h / -30 °C 4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 5: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr View Scheme | |
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 3 h / -5 °C 2: N,O-Bis(trimethylsilyl)acetamide; tetrabutyl ammonium fluoride / toluene / 48 h / Reflux 3: formic acid / dichloromethane / 12 h / Reflux View Scheme |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
ezetemibe
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C 2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C 3: BF3 etherate / toluene / 0.08 h / -30 °C 4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 5: 90 percent / hydrogen / 10 percent Pd/C / methanol; ethyl acetate / 3 h / 1551.44 Torr 6: 79 percent / bistrimethylsilylurea; BH3-Me2S / CH2Cl2 / 5 h / -20 - -15 °C View Scheme | |
Multi-step reaction with 7 steps 1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C 2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C 3: BF3 etherate / toluene / 0.08 h / -30 °C 4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 5: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr 6: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C 7: 79 percent / ammonium formate; HOAc / Pd-C / methanol / 3 h / 45 - 55 °C / pH 3 - 5 View Scheme | |
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 3 h / -5 °C 2: N,O-Bis(trimethylsilyl)acetamide; tetrabutyl ammonium fluoride / toluene / 48 h / Reflux 3: formic acid / dichloromethane / 12 h / Reflux 4: dimethyl sulfide borane / dichloromethane; toluene; tetrahydrofuran / 12 h / 15 °C 5: acetic acid; ammonium formate; palladium 10% on activated carbon / 6 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 5 h / -30 - -20 °C 2.1: tetrabutyl ammonium fluoride / toluene / 3 h / 60 °C 3.1: sulfuric acid / isopropyl alcohol / 1 h / 20 °C 3.2: 2 h / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride / toluene / 60 °C 2: dimethylsulfide borane complex / dichloromethane; toluene / 3 h / -5 - 0 °C / Inert atmosphere 3: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h View Scheme |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C 2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C 3: BF3 etherate / toluene / 0.08 h / -30 °C 4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C 5: 71 percent / (PPh3)3RhCl; hydrogen / CH2Cl2 / 18 h / 3102.89 Torr 6: 70 percent / CBS; BH3-Me2S / toluene; CH2Cl2 / 2 h / -20 °C View Scheme | |
Multi-step reaction with 4 steps 1: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 3 h / -5 °C 2: N,O-Bis(trimethylsilyl)acetamide; tetrabutyl ammonium fluoride / toluene / 48 h / Reflux 3: formic acid / dichloromethane / 12 h / Reflux 4: dimethyl sulfide borane / dichloromethane; toluene; tetrahydrofuran / 12 h / 15 °C View Scheme | |
Multi-step reaction with 2 steps 1: N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride / toluene / 60 °C 2: dimethylsulfide borane complex / dichloromethane; toluene / 3 h / -5 - 0 °C / Inert atmosphere View Scheme |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
(2S,3S)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxazetidine-3-carbaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C 2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / -30 °C / Inert atmosphere 1.2: 3 h / -30 - -20 °C 2.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 3 h / 50 °C 2.2: 2 h / Reflux 3.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / -45 - 20 °C View Scheme |
4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine
(3R,4S)-4-(4-Benzyloxy-phenyl)-1-(4-fluoro-phenyl)-3-[(E)-3-(4-fluoro-phenyl)-3-oxo-propenyl]-azetidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 64 percent / LDA; DMPU; LiCl / dimethylformamide; tetrahydrofuran / 18 h / -30 - -25 °C 2: 90 percent / NaIO4 / acetonitrile; H2O / 2 h / 20 °C 3: BF3 etherate / toluene / 0.08 h / -30 °C 4: 99 g / p-toluenesulfonic acid monohydrate; molecular sieves / toluene / 4 h / 40 - 50 °C View Scheme |
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