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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-[[(4-Fluorophenyl)imino]methyl]-phenol Manufacturer/High quality/Best price/In stock

Cas:3382-63-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product informations Product Name 4-[[(4-Fluorophenyl)imino Methyl-phenol CAS No. 3382-63-6

4-[[(4-Fluorophenyl)imino Methyl-phenol

Cas:3382-63-6

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

4-[[(4-Fluorophenyl)imino]methyl]-phenol CAS No.:3382-63-6 Name: 4-[[(4-Fluorophenyl)imino]methyl]-phenol Molecular Structure: Molecular Formula: C13H10FNO Molecular Weight: 215.23 CAS Re

High purity 4-[[(4-Fluorophenyl)imino]methyl]-phenol CAS No.:3382-63-6

Cas:3382-63-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-[(4-Fluorophenylimino)methyl]phenol

Cas:3382-63-6

Min.Order:1

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Application:intermediate Port:shanghai

3382-63-6 4-[[(4-Fluorophenyl)imino]methyl]-phenol

Cas:3382-63-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 3382-63-6 4-[[(4-Fluorophenyl)imino]methyl]-phenol Manufacturer

Cas:3382-63-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-[[(Fluorophenyl)-imino]-methyl]-phenol

Cas:3382-63-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

Highest quality CAS NO. 3382-63-6 for ezetimibe intermediate

Cas:3382-63-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--3382-63-6-- 4-[[(4-Fluorophenyl)imino]methyl]-phenol in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stab

TIANFUCHEM--3382-63-6-- 4-[[(4-Fluorophenyl)imino]methyl]-phenol in stock

Cas:3382-63-6

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

4-[[(4-Fluorophenyl)imino]methyl]-phenol

Cas:3382-63-6

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 3382-63-6 with competitive price

Cas:3382-63-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name 4-[[(4-Fluorophenyl)imino]methyl]-phenol CAS 3382-63-6 MF C13H10FNO MW

4-[[(4-Fluorophenyl)imino]methyl]-phenol

Cas:3382-63-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-[[(4-Fluorophenyl)imino]methyl]-phenol 3382-63-6

Cas:3382-63-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

4-[[(4-Fluorophenyl)imino]methyl]-phenol

Cas:3382-63-6

Min.Order:1 Kilogram

FOB Price: $68.0 / 75.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

4-[[(4-Fluorophenyl)imino]methyl]-phenol CAS: 3382-63-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high

4-[[(4-Fluorophenyl)imino]methyl]-phenol CAS: 3382-63-6

Cas:3382-63-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

4-[[(4-Fluorophenyl)imino]methyl]-phenol CAS: 3382-63-6 Specification Product Name 4-[[(4-Fluorophenyl)imino Methyl-phenol CAS No. 3382-63-6 Appearance White or off

Factory supply 4-[[(4-Fluorophenyl)imino]methyl]-phenol

Cas:3382-63-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-[[(4-Fluorophenyl)imino]methyl]-phenol

Cas:3382-63-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-(4-Fluorophenylimino)Methyl)Phenol

Cas:3382-63-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

4-[[(4-Fluorophenyl)imino]methyl]-phenol

Cas:3382-63-6

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-[[(4-FLUOROPHENYL)IMINO]METHYL]-PHENOL

Cas:3382-63-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-[[(4-Fluorophenyl)imino]methyl]-phenol C13H10FNO

Cas:3382-63-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-(4 ' -Hydrophenyl)-4-fluorobenyl imine

Cas:3382-63-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co

Phenol, 4-[[(4-fluorophenyl)imino]methyl]-

Cas:3382-63-6

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

3382-63-6 4-[[(4-Fluorophenyl)imino]methyl]-phenol Appearance:white powder Storage:room temperature Package:according to customers' requirements Application:Pharma intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FO

3382-63-6 4-[[(4-Fluorophenyl)imino]methyl]-phenol

Cas:3382-63-6

Min.Order:1 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. It is made obtainable from us at the most reasonable rate. Our Service: 1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical are

Ezetimibe Impurity (E)-4-(((4-fluorophenyl) imino)methyl)phenol CAS 3382-63-6

Cas:3382-63-6

Min.Order:1 Kilogram

FOB Price: $4.8 / 5.0

Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4-[[(4-Fluorophenyl)imino]methyl]-phenol

Cas:3382-63-6

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 4-(4-Fluorophenylimino)Methyl)Phenol

Cas:3382-63-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Synthetic route

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

4-fluoroaniline
371-40-4

4-fluoroaniline

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Conditions
ConditionsYield
In water at 20 - 85℃; for 5.5h; Large scale;97.5%
In methanol at 20 - 30℃; Large scale;90%
In isopropyl alcohol at 50℃; for 1h;88%
ezetemibe
163222-33-1

ezetemibe

A

(-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one
793673-93-5

(-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one

B

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Conditions
ConditionsYield
In water; acetonitrile UV-irradiation;
p-azidofluorobenzene
3296-02-4

p-azidofluorobenzene

trans-4-Hydroxystilbene
6554-98-9

trans-4-Hydroxystilbene

A

N-benzylidene-4-fluoroaniline
331-98-6, 83306-62-1, 83306-65-4

N-benzylidene-4-fluoroaniline

B

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Conditions
ConditionsYield
With iron(II) chloride In acetonitrile at 100℃; Sealed tube; Inert atmosphere;
4-fluoroaniline
371-40-4

4-fluoroaniline

A

N-benzylidene-4-fluoroaniline
331-98-6, 83306-62-1, 83306-65-4

N-benzylidene-4-fluoroaniline

B

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C / Inert atmosphere
1.2: 10 h / 20 °C / Inert atmosphere
2.1: iron(II) chloride / acetonitrile / 100 °C / Sealed tube; Inert atmosphere
View Scheme
4-hydroxybenzenediazonium tetrafluoroborate

4-hydroxybenzenediazonium tetrafluoroborate

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate; palladium diacetate / 12 h / 20 °C / Inert atmosphere
2: iron(II) chloride / acetonitrile / 100 °C / Sealed tube; Inert atmosphere
View Scheme
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

N-(4-((tert-butyldimethylsilyl)oxy)benzylidene)-4-fluoroaniline
179411-51-9

N-(4-((tert-butyldimethylsilyl)oxy)benzylidene)-4-fluoroaniline

Conditions
ConditionsYield
Stage #1: N-(4-hydroxybenzylidene)-4-fluorobenzenamine With dmap; triethylamine In dichloromethane at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: tert-butyldimethylsilyl chloride In dichloromethane at 0 - 20℃; Inert atmosphere;
99%
With 1H-imidazole In N,N-dimethyl-formamide at 60℃; for 4h;97.5%
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

acetyl chloride
75-36-5

acetyl chloride

C15H12FNO2

C15H12FNO2

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 5h;98%
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

trityl chloride
76-83-5

trityl chloride

N-(4-trityloxybenzylidene)-4-fluoroaniline
1159183-26-2

N-(4-trityloxybenzylidene)-4-fluoroaniline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 10 - 20℃; for 1.08333h;97.8%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 10 - 20℃;
With N-ethyl-N,N-diisopropylamine In dichloromethane at 10 - 20℃;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone
1076200-08-2

3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one
858126-22-4

3-{2-[3-(fluorophenyl)-3-(trimethyl silyloxy)-propyl]-3-(4-fluoro phenyl amino)-3-(4-trimethyl silyloxy phenyl)-1-oxo-propyl}-4-(S)-phenyl oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: 3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-2-oxazolidinone With dimethylsulfide borane complex; ascorbic acid; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In dichloromethane at -10 - 8℃; for 7.25h; Inert atmosphere; Large scale;
Stage #2: With dihydrogen peroxide In methanol; dichloromethane at -5 - 20℃; for 0.5h; Inert atmosphere; Large scale;
Stage #3: chloro-trimethyl-silane; N-(4-hydroxybenzylidene)-4-fluorobenzenamine Large scale; Further stages;
96.3%
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

2,2,2-Trichloroethyl chloroformate
17341-93-4

2,2,2-Trichloroethyl chloroformate

C16H11Cl3FNO3

C16H11Cl3FNO3

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 5℃; for 6h;95%
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

pivaloyl chloride
3282-30-2

pivaloyl chloride

2,2-dimethylpropionic acid 4-[(4-fluorophenylimino)methyl]phenyl ester
1232148-23-0

2,2-dimethylpropionic acid 4-[(4-fluorophenylimino)methyl]phenyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane93%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate
870634-36-9

methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

(3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-(trimethylsilyloxy)propanyl)-4-(4-(trimethylsiloxy)phenyl)azetidinone

(3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-(trimethylsilyloxy)propanyl)-4-(4-(trimethylsiloxy)phenyl)azetidinone

Conditions
ConditionsYield
Stage #1: chloro-trimethyl-silane; methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate; N-(4-hydroxybenzylidene)-4-fluorobenzenamine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -10 - 0℃; Inert atmosphere;
Stage #2: With (R,R)-(+)-N-benzyl-3,4-bis(diphenylphosphino)pyrrolidine; lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at -10 - 0℃; Inert atmosphere;
79%
methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate
870634-36-9

methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate

triethylsilyl chloride
994-30-9

triethylsilyl chloride

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

C36H49F2NO3Si2

C36H49F2NO3Si2

Conditions
ConditionsYield
Stage #1: methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate; triethylsilyl chloride; N-(4-hydroxybenzylidene)-4-fluorobenzenamine With tributyl-amine In 2-methyltetrahydrofuran at -10 - 0℃; Inert atmosphere;
Stage #2: With (R,R)-(+)-N-benzyl-3,4-bis(diphenylphosphino)pyrrolidine; lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at -10 - 0℃; Inert atmosphere;
78.3%
methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate
870634-36-9

methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate

chlorotripropylsilane
995-25-5

chlorotripropylsilane

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

C42H61F2NO3Si2

C42H61F2NO3Si2

Conditions
ConditionsYield
Stage #1: methyl 5S-5-(4-fluorophenyl)-5-hydroxyvalerate; chlorotripropylsilane; N-(4-hydroxybenzylidene)-4-fluorobenzenamine With triethylamine In 2-methyltetrahydrofuran at -20 - -10℃; Inert atmosphere;
Stage #2: With (R,R)-(+)-N-benzyl-3,4-bis(diphenylphosphino)pyrrolidine; lithium diisopropyl amide In tetrahydrofuran; n-heptane; ethylbenzene at -20 - -10℃; Inert atmosphere;
76.7%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

C20H19ClFNO4

C20H19ClFNO4

C39H45ClF2N2O5Si2

C39H45ClF2N2O5Si2

Conditions
ConditionsYield
Stage #1: chloro-trimethyl-silane; N-(4-hydroxybenzylidene)-4-fluorobenzenamine; C20H19ClFNO4 With N-ethyl-N,N-diisopropylamine for 1h;
Stage #2: With titanium tetrachloride at -30 - -25℃; for 3h;
71%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

(4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]({4-[(trimethylsilyl)oxy]phenyl})methyl]-5-[(trimethylsilyl)oxy]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one
272778-12-8

(4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]({4-[(trimethylsilyl)oxy]phenyl})methyl]-5-[(trimethylsilyl)oxy]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: chloro-trimethyl-silane; N-(4-hydroxybenzylidene)-4-fluorobenzenamine; (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one With N-ethyl-N,N-diisopropylamine In dichloromethane at -10 - 0℃; Inert atmosphere;
Stage #2: With titanium tetrachloride In dichloromethane at -30 - -25℃; Inert atmosphere;
66.6%
With triethylamine In dichloromethane at -20℃; Reagent/catalyst; Solvent;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

C39H46F2N2O5Si2

C39H46F2N2O5Si2

Conditions
ConditionsYield
Stage #1: N-(4-hydroxybenzylidene)-4-fluorobenzenamine; (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one With N-ethyl-N,N-diisopropylamine In dichloromethane at -10 - -5℃;
Stage #2: chloro-trimethyl-silane In dichloromethane at -5℃; for 1.5h;
Stage #3: With N,O-bis-(trimethylsilyl)-acetamide; titanium tetrachloride more than 3 stages;
65%
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

C37H38F2N2O7

C37H38F2N2O7

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at -20 - -10℃; for 1h; Temperature; Reagent/catalyst;64.5%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

(4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]({4-[(trimethylsilyl)oxy]phenyl})methyl]-5-[(trimethylsilyl)oxy]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one
272778-12-8

(4S)-3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino]({4-[(trimethylsilyl)oxy]phenyl})methyl]-5-[(trimethylsilyl)oxy]pentanoyl]-4-phenyl-1,3-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: chloro-trimethyl-silane; N-(4-hydroxybenzylidene)-4-fluorobenzenamine; (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one With N-ethyl-N,N-diisopropylamine In dichloromethane at -10 - -5℃; for 1h;
Stage #2: With titanium tetrachloride In dichloromethane at -30℃; for 20h;
Stage #3: N,O-bis-(trimethylsilyl)-acetamide
60%
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

m-nitrobenzoic acid chloride
121-90-4

m-nitrobenzoic acid chloride

C20H13FN2O4

C20H13FN2O4

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20 - 30℃; Large scale;59%
(S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one
1185883-41-3

(S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

benzyl chloroformate
501-53-1

benzyl chloroformate

C41H34F2N2O7
1185883-42-4

C41H34F2N2O7

Conditions
ConditionsYield
Stage #1: N-(4-hydroxybenzylidene)-4-fluorobenzenamine; benzyl chloroformate With N-ethyl-N,N-diisopropylamine In dichloromethane; toluene at 0 - 20℃; for 1.66667h;
Stage #2: (S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one With titanium(IV) trichloride isopropoxide In dichloromethane; toluene at -35 - -30℃; for 3.33333h;
51.76%
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

stearic acid
57-11-4

stearic acid

C31H44FNO2

C31H44FNO2

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran for 6h;45%
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

C29H40FNO2

C29H40FNO2

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran for 6h;44%
lauric acid
143-07-7

lauric acid

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

C25H32FNO2

C25H32FNO2

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran for 6h;41%
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

n-tetradecanoic acid
544-63-8

n-tetradecanoic acid

C27H36FNO2

C27H36FNO2

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran for 6h;41%
1-decanoic acid
334-48-5

1-decanoic acid

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

C23H28FNO2

C23H28FNO2

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran for 6h;38%
N-(2-chloroethyl)-pyrrolidine
5050-41-9

N-(2-chloroethyl)-pyrrolidine

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

4-fluorophenyl[4-(2-pyrrolidin-1-yl-ethoxy)benzylidene]amine

4-fluorophenyl[4-(2-pyrrolidin-1-yl-ethoxy)benzylidene]amine

Conditions
ConditionsYield
Stage #1: N-(4-hydroxybenzylidene)-4-fluorobenzenamine With potassium carbonate In acetone for 0.166667h; Inert atmosphere;
Stage #2: N-(2-chloroethyl)-pyrrolidine In acetone Inert atmosphere; Reflux;
37%
3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone

3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

C39H47FN2O4Si2

C39H47FN2O4Si2

Conditions
ConditionsYield
Stage #1: 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone; N-(4-hydroxybenzylidene)-4-fluorobenzenamine With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; titanium tetrachloride In n-heptane; toluene at -35 - -10℃; for 4.75h;
Stage #2: With bistrimethylsilylacetamide In n-heptane; toluene for 0.5h; Heating / reflux;
(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one
942485-56-5

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

(S)-3-{(R)-2-[(S)-(4-fluorophenylamino)-(4-hydroxyphenyl)methyl]-4-[2-(4-fluorophenyl)-[1,3]-dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one
954109-25-2

(S)-3-{(R)-2-[(S)-(4-fluorophenylamino)-(4-hydroxyphenyl)methyl]-4-[2-(4-fluorophenyl)-[1,3]-dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one

Conditions
ConditionsYield
Stage #1: (S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one; N-(4-hydroxybenzylidene)-4-fluorobenzenamine With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine In dichloromethane at -10℃; for 1.5h;
Stage #2: With titanium tetrachloride In dichloromethane at -15℃;
N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

benzyl chloroformate
501-53-1

benzyl chloroformate

benzyl-[4-(4-fluorophenyliminomethyl)phenyl]-carbonate
1159183-27-3

benzyl-[4-(4-fluorophenyliminomethyl)phenyl]-carbonate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane; toluene at 5 - 10℃;
With N-ethyl-N,N-diisopropylamine In dichloromethane; toluene at 5 - 10℃; for 1.08333h;
Reaxys ID: 19845321

Reaxys ID: 19845321

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

Reaxys ID: 19845322

Reaxys ID: 19845322

Reaxys ID: 19845323

Reaxys ID: 19845323

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

Reaxys ID: 19845322

Reaxys ID: 19845322

Conditions
ConditionsYield
With titanium tetrachloride; N-ethyl-N,N-diisopropylamine In dichloromethane
(S)-3-(5-(4-fluorophenyl)-5-(hydroxyimino)pentanoyl)-4-phenyloxazolidin-2-one

(S)-3-(5-(4-fluorophenyl)-5-(hydroxyimino)pentanoyl)-4-phenyloxazolidin-2-one

N-(4-hydroxybenzylidene)-4-fluorobenzenamine
3382-63-6

N-(4-hydroxybenzylidene)-4-fluorobenzenamine

C39H45F2N3O5Si2

C39H45F2N3O5Si2

Conditions
ConditionsYield
Stage #1: (S)-3-(5-(4-fluorophenyl)-5-(hydroxyimino)pentanoyl)-4-phenyloxazolidin-2-one; N-(4-hydroxybenzylidene)-4-fluorobenzenamine With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine In dichloromethane at -10 - -5℃;
Stage #2: titanium tetrachloride In dichloromethane at -30 - -25℃; for 3 - 6h;

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