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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti

Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ethyl 3,4-Bis(2-Methoxyethoxy)Benzoate supplier in China

Cas:183322-16-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:1

Negotiable

Type:Other

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

CAS:183322-16-9/High quality/Factory supply

Cas:183322-16-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ethyl 3,4-bis-(2-methoxyethoxy)-benzoate

Cas:183322-16-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester CAS NO:183322-16-9 Grade:Used as food additives, pharmaceutical intermediates, etc; Erotinib hydrochloride intermediate Product Quality 12 years of chemical raw materials Mature operation of

3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester CAS:183322-16-9 Chinese manufacturers high-quality

Cas:183322-16-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/564.html Product Name Ethyl 3,4-bis(2-methoxyethoxy)be

Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:1 Gram

FOB Price: $43.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Ethyl 3,4-bis(2-methoxyethoxy)benzoate Basic information Product Name: Ethyl 3,4-bis(2-methoxyethoxy)benzoate Synonyms: 3,4-Bis(2-methoxyethoxy)benzoic acid ethyl e

183322-16-9

Cas:183322-16-9

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 183322-16-9 with best quality

Cas:183322-16-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white or off-white powder Storage:Store in sealed containers

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzoic acid,3,4-bis(2-methoxyethoxy)-, ethyl ester 183322-16-9

Cas:183322-16-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Ethyl 3,4-bis(2-methoxyethoxy)benzoate CAS:183322-16-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q

Ethyl 3,4-bis(2-methoxyethoxy)benzoate CAS:183322-16-9

Cas:183322-16-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzoic acid,3,4-bis(2-methoxyethoxy)-, ethyl ester

Cas:183322-16-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:183322-16-9

Cas:183322-16-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

3,-bis(2-methoxyethoxy)-benzoic acid ethyl ester

Cas:183322-16-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl 3,4-Bis(2-Methoxyethoxy) Benzoate

Cas:183322-16-9

Min.Order:0

Negotiable

Type:Manufacturers

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 183322-16-9 Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3,-bis(2-methoxyethoxy)-benzoic acid ethyl ester

Cas:183322-16-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Ethyl 3,4-Bis(2-Methoxyethoxy)Benzoate

Cas:183322-16-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

Ethyl 3,4-bis(2-methoxyethoxy)benzoate;cas.183322-16-9;98%;ready stock, competitive priceAppearance:White powder Storage:Store in an airtight container, protected from light. Package:according to customers' requirements Application:This product is an

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

3,-bis(2-methoxyethoxy)-benzoic acid ethyl ester

Cas:183322-16-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Erlotinib Intermediate I CAS No.: 183322-16-9 Molecule Formula:C15H22O6 Molecule Weight:298.33 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTI

Lower Price Erlotinib Intermediate I

Cas:183322-16-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Ethyl 3,4-bis(2-methoxyethoxy)benzoate Basic information Product Name: Ethyl 3,4-bis(2-methoxyethoxy)benzoate Synonyms: 3,4-Bis(2-methoxyethoxy)benzoic acid ethyl ester;Ethyl 3,4-bis(2-methoxyethoxy)benzoate;Thyl3,4-bis(2-methoxyethoxy)benzoat

Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ethyl 3,4-bis(2-methoxyethoxy)benzoate

Cas:183322-16-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

BEST PRICE/Ethyl3,4-bis(2-methoxyethoxy)benzoate CAS NO.183322-16-9 CAS NO.183322-16-9

Cas:183322-16-9

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Synthetic route

Ethyl protocatechuate
3943-89-3

Ethyl protocatechuate

2-Bromoethyl methyl ether
6482-24-2

2-Bromoethyl methyl ether

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetone at 60℃; for 19h; Inert atmosphere;100%
With potassium carbonate In acetone at 20 - 70℃; for 24h;93%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 64h; Inert atmosphere; Reflux;93%
3,4-bis(2-methoxyethoxy)-benzoic acid
819813-71-3

3,4-bis(2-methoxyethoxy)-benzoic acid

ethanol
64-17-5

ethanol

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid Cooling with ice; Reflux;98%
2-chloroethyl methyl ether
627-42-9

2-chloroethyl methyl ether

Ethyl protocatechuate
3943-89-3

Ethyl protocatechuate

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

Conditions
ConditionsYield
With 4-(Methylamino)pyridine; potassium carbonate at 90 - 95℃; Temperature; Reagent/catalyst;95%
With carbon dioxide; ammonia at 50℃; for 0.5h; Temperature; Reagent/catalyst;94.6%
With potassium tert-butylate; potassium iodide In N,N-dimethyl-formamide at 100℃; for 12h;87%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 120h; Heating;
With potassium carbonate In N,N-dimethyl-formamide at 90 - 100℃; for 9h;95 %Chromat.
2-methoxyethyl methanesulfonate
16427-44-4

2-methoxyethyl methanesulfonate

Ethyl protocatechuate
3943-89-3

Ethyl protocatechuate

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In toluene for 6h; Reflux;95%
With potassium tert-butylate; tetrabutylammomium bromide In N,N-dimethyl-formamide at 30 - 40℃; for 10h;90.5%
Ethyl protocatechuate
3943-89-3

Ethyl protocatechuate

2-methoxy-ethyl p-toluenesulfonyloxy ester
17178-10-8

2-methoxy-ethyl p-toluenesulfonyloxy ester

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 6h; Reflux;89%
With potassium carbonate In acetonitrile for 6h; Reflux;89%
4-chloro-6,7-di-(2-methoxyethoxy)quinazoline hydrochloride

4-chloro-6,7-di-(2-methoxyethoxy)quinazoline hydrochloride

Ethyl protocatechuate
3943-89-3

Ethyl protocatechuate

2-Bromoethyl methyl ether
6482-24-2

2-Bromoethyl methyl ether

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone
3,4-Dihydroxybenzoic acid
99-50-3

3,4-Dihydroxybenzoic acid

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid / 10 h / 40 - 80 °C
2: potassium tert-butylate; potassium iodide / N,N-dimethyl-formamide / 12 h / 100 °C
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester
179688-26-7

2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid; nitric acid In acetic acid at 20 - 70℃; for 2h;100%
With sulfuric acid; nitric acid In acetic acid at 15 - 35℃;100%
With sulfuric acid; nitric acid; acetic anhydride; acetic acid at 40℃; for 2h; Concentration; Large scale;98.3%
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

C15H22O7

C15H22O7

Conditions
ConditionsYield
Stage #1: 3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester In tetrahydrofuran for 0.5h; Reflux;
Stage #2: With peracetic acid; dinitrogen monoxide In tetrahydrofuran at 50℃; under 22502.3 Torr; for 2h; Reagent/catalyst; Temperature; Autoclave;
95.2%
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

3,4-bis(2-methoxyethoxy)-benzoic acid
819813-71-3

3,4-bis(2-methoxyethoxy)-benzoic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 3h;90%
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; nitric acid / 24 h / 20 °C
2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
3: 84 percent / 12 h / 165 - 170 °C
View Scheme
Multi-step reaction with 3 steps
1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C
2: 94 percent / hydrogen / palladium on activated carbon / methanol
3: 62 percent / formamide / 3 h / 160 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid; nitric acid / 0 °C
2: hydrogen; palladium on activated charcoal / methanol
3: 165 - 170 °C
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid; nitric acid / 24 h / 20 °C
2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
3: 84 percent / 12 h / 165 - 170 °C
4: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
View Scheme
Multi-step reaction with 4 steps
1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C
2: 94 percent / hydrogen / palladium on activated carbon / methanol
3: 62 percent / formamide / 3 h / 160 °C
4: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetic acid; nitric acid / 24 h / 20 °C
2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
3: 84 percent / 12 h / 165 - 170 °C
4: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
5: pyridine / propan-2-ol
View Scheme
Multi-step reaction with 6 steps
1.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness
2.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C
2.2: 20 °C
3.1: ammonium formate; triethylamine / 6 h / 160 °C
4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C
5.1: methanol / 3 h / 20 - 30 °C
5.2: 3 h / 50 °C
6.1: hydrogenchloride / water; dichloromethane; methanol / 3 h / 25 °C
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
179688-27-8

ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; nitric acid / 24 h / 20 °C
2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
View Scheme
Multi-step reaction with 2 steps
1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C
2: 94 percent / hydrogen / palladium on activated carbon / methanol
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / acetic acid / 15 - 35 °C
2: hydrogen; platinum on carbon / methanol / 20 - 40 °C / 760.05 Torr
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

4-(3'-chloro-4'-fluoroanilino)-6,7-bis(2-methoxyethoxy)-quinazoline

4-(3'-chloro-4'-fluoroanilino)-6,7-bis(2-methoxyethoxy)-quinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C
2: 94 percent / hydrogen / palladium on activated carbon / methanol
3: 62 percent / formamide / 3 h / 160 °C
4: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating
5: 53 percent / pyridine / propan-2-ol / 2 h / Heating
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one
179688-29-0

6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
View Scheme
Multi-step reaction with 2 steps
1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice
2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuric acid; nitric acid / acetic acid / 15 - 35 °C
2.1: hydrogen; platinum on carbon / methanol / 20 - 40 °C / 760.05 Torr
3.1: N,N-dimethyl-formamide / 10 h / 130 - 140 °C
3.2: 65 - 80 °C
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-chloro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
1347720-71-1

9-chloro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: isopropyl alcohol / 4 h / Reflux
5.1: trichlorophosphate / 2 h / Reflux
5.2: pH 10
View Scheme
Multi-step reaction with 5 steps
1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice
2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C
3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
4: isopropyl alcohol / 4 h / Reflux
5: trichlorophosphate / 2 h / Reflux
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-bromo-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
1347720-74-4

9-bromo-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: pyridine / acetonitrile / 4 h / Reflux
5.1: trichlorophosphate / 2 h / Reflux
5.2: pH 9
View Scheme
Multi-step reaction with 5 steps
1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice
2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C
3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
4: pyridine / acetonitrile / 4 h / Reflux
5: trichlorophosphate / 2 h / Reflux
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-fluoro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
1347719-30-5

9-fluoro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: hydrogenchloride / isopropyl alcohol; water
5.1: triethylamine; methanesulfonyl chloride / toluene / 7 h / 20 °C / cooling with ice
View Scheme
Multi-step reaction with 5 steps
1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice
2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C
3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
4: hydrogenchloride / isopropyl alcohol; water / 20 °C
5: triethylamine; methanesulfonyl chloride / toluene / 7 h / 20 °C / Cooling with ice
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-ethynyl-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
1347720-79-9

9-ethynyl-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: pyridine / acetonitrile / 4 h / Reflux
5.1: trichlorophosphate / 2 h / Reflux
5.2: pH 9
6.1: hydrogenchloride / ethanol; water / Heating
7.1: triethylamine / triphenylphosphine; palladium diacetate; copper(l) iodide / 7 h / Inert atmosphere; Reflux
8.1: sodium hydroxide / toluene / 6 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 8 steps
1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice
2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C
3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
4: pyridine / acetonitrile / 4 h / Reflux
5: trichlorophosphate / 2 h / Reflux
6: hydrogenchloride / ethanol / Heating
7: triethylamine; triphenylphosphine; palladium diacetate; copper(l) iodide / 7 h / Inert atmosphere; Reflux
8: sodium hydroxide / toluene / 4 h / Resolution of racemate; Inert atmosphere
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-nitro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
1347719-34-9

9-nitro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: hydrogenchloride / 1,4-dioxane; water / 7 h / 20 °C
5.1: triethylamine; methanesulfonyl chloride / chloroform / 20 °C / cooling with ice
View Scheme
Multi-step reaction with 5 steps
1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice
2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C
3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
4: hydrogenchloride / water; 1,4-dioxane / 7 h / 20 °C
5: triethylamine; methanesulfonyl chloride / chloroform / 20 °C
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-amino-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline
1347720-84-6

9-amino-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: hydrogenchloride / 1,4-dioxane; water / 7 h / 20 °C
5.1: triethylamine; methanesulfonyl chloride / chloroform / 20 °C / cooling with ice
6.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 760.05 Torr / Reflux
View Scheme
Multi-step reaction with 6 steps
1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice
2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C
3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
4: hydrogenchloride / water; 1,4-dioxane / 7 h / 20 °C
5: triethylamine; methanesulfonyl chloride / chloroform / 20 °C
6: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 760.05 Torr / Reflux
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-chloro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline hydrochloride

9-chloro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: isopropyl alcohol / 4 h / Reflux
5.1: trichlorophosphate / 2 h / Reflux
5.2: pH 10
6.1: hydrogenchloride / ethanol; water / Heating
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-fluoro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline mesylate

9-fluoro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline mesylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: hydrogenchloride / isopropyl alcohol; water
5.1: triethylamine; methanesulfonyl chloride / toluene / 7 h / 20 °C / cooling with ice
6.1: ethanol / 0.5 h / Reflux
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-ethynyl-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline hydrochloride

9-ethynyl-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: pyridine / acetonitrile / 4 h / Reflux
5.1: trichlorophosphate / 2 h / Reflux
5.2: pH 9
6.1: hydrogenchloride / ethanol; water / Heating
7.1: triethylamine / triphenylphosphine; palladium diacetate; copper(l) iodide / 7 h / Inert atmosphere; Reflux
8.1: sodium hydroxide / toluene / 6 h / Inert atmosphere; Reflux
9.1: hydrogenchloride / ethanol
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-amino-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline hydrobromide

9-amino-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: hydrogenchloride / 1,4-dioxane; water / 7 h / 20 °C
5.1: triethylamine; methanesulfonyl chloride / chloroform / 20 °C / cooling with ice
6.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 760.05 Torr / Reflux
7.1: hydrogen bromide / ethyl acetate; ethanol
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

C21H24ClN3O5
1347720-70-0

C21H24ClN3O5

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: isopropyl alcohol / 4 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice
2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C
3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
4: isopropyl alcohol / 4 h / Reflux
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

C21H24BrN3O5
1347720-73-3

C21H24BrN3O5

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: pyridine / acetonitrile / 4 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice
2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C
3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
4: pyridine / acetonitrile / 4 h / Reflux
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

9-bromo-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline hydrochloride

9-bromo-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: pyridine / acetonitrile / 4 h / Reflux
5.1: trichlorophosphate / 2 h / Reflux
5.2: pH 9
6.1: hydrogenchloride / ethanol; water / Heating
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

C21H24FN3O5
1347720-76-6

C21H24FN3O5

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
4.1: hydrogenchloride / isopropyl alcohol; water
View Scheme
Multi-step reaction with 4 steps
1: nitric acid; acetic acid / 24 h / 20 °C / Cooling with ice
2: ammonium formate; 5%-palladium/activated carbon / 7 h / 150 °C
3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
4: hydrogenchloride / isopropyl alcohol; water / 20 °C
View Scheme

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