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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Manufacturer/High quality/Best price/In stock

Cas:179688-29-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Off white powder Conforms Melting point 182.0~184.0℃

High purity Various Specifications 6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one CAS:179688-29-0

Cas:179688-29-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 6,7-Bis-(2-Methoxyethoxy)-Quinazolin-4(3H)-One supplier in China

Cas:179688-29-0

Min.Order:1 Kilogram

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Nanjing Yuance Industry&Trade Co., Ltd.

Purity 98% with good quality Competitive price Fast delivery Prompt shipment Appearance:White powder Storage:Store in cool dry place Package:25 kg/drum Application:Pharmaceutical intermediates Port:Shanghai, Nanjing

6,7-bis-(2-Methoxyethoxy)-quinazolin-4(3h)-one

Cas:179688-29-0

Min.Order:1 Metric Ton

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Jinan Finer Chemical Co., Ltd

Product Description 6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one

6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one

Cas:179688-29-0

Min.Order:10 Gram

FOB Price: $20.0 / 30.0

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Hangzhou Think Chemical Co. Ltd

Erlotinib Intermediate 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone[CAS:179688-29-0] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years

High purity 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone for Erlotinib

Cas:179688-29-0

Min.Order:1 Kilogram

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one

Cas:179688-29-0

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

Basic information Product Name: 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Synonyms: 6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(1H)-ONE;6,7-bis(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one;6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone;6

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Cas:179688-29-0

Min.Order:1 Kilogram

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Hebei yanxi chemical co.,LTD.

Our advantage: 1: High quality and Competitive price 2: Quality control, GC&HPLC&NMR or as your requested 3: Packing as your requested, and double check before shipment 4: Prompt shipment with professional documents 5: Excellent after-

6,7-Bis-(2-Methoxyethoxy)-4(3H)-Quinazolinone CAS NO.179688-29-0

Cas:179688-29-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6,7-bis-(2-methoxyethoxy)-quinazolin-4(3h)-one

Cas:179688-29-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name: 6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one CAS NO:179688-29-0 Grade:Erotinib intermediate pharmaceutical intermediate Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage S

6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one CAS:179688-29-0 Chinese manufacturers high-quality

Cas:179688-29-0

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM -6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Cas:179688-29-0

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Name: 6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one CAS: 179688-29-0 Our factory capacity: 50kg/month Other name: Erlotinib interMidiate V Package: 25kg/drum Erlotinib hydrochloride & Intermediates Erlotinib hydrochloride 183319-6

6, 7-Bis- (2-methoxyethoxy) - 4 (3H) -Quinazolinone CAS 179688-29-0

Cas:179688-29-0

Min.Order:1 Kilogram

FOB Price: $2.0 / 55.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 179688-29-0 with best quality

Cas:179688-29-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name Erlotinib Intermediates 6,7-bis-(2-Methoxyethoxy)-quinazolin-4(3h)-one CAS NO. 179688-29-0 Synonyms 6,7-bis-(2-Methoxyethoxy)-quinazolin-4(3h)-one

6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one

Cas:179688-29-0

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Cas:179688-29-0

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Cas:179688-29-0

Min.Order:1 Gram

FOB Price: $1.0

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Qingdao Beluga Import and Export Co., LTD

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone CAS: 179688-29-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone CAS: 179688-29-0

Cas:179688-29-0

Min.Order:1 Gram

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Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Cas:179688-29-0

Min.Order:1 Kilogram

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone/ LIDE PHARMA- Factory supply / Best price

Cas:179688-29-0

Min.Order:0

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Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail bes

Factory price 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone CAS:179688-29-0

Cas:179688-29-0

Min.Order:100 Kilogram

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Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Cas:179688-29-0

Min.Order:1 Kilogram

FOB Price: $20.0 / 50.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Cas:179688-29-0

Min.Order:0

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Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

6,7-Bis-(2-Methoxyethoxy)-4(3H)-Quinazolinone

Cas:179688-29-0

Min.Order:0

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Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one

Cas:179688-29-0

Min.Order:100 Gram

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Cas:179688-29-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Synonyms: 6,7-bis(2-Methoxyethoxy)-3,4-dihydroquinazolin-4-one;6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone;6,7-Bis-(2-Methoxyethoxy)quinazolin-4(3H)-one;6,7-bis(2-methoxyethoxy)-1H-qu

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone Manufactuered in China best quality

Cas:179688-29-0

Min.Order:100 Gram

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Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 179688-29-0 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Cas:179688-29-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

Cas:179688-29-0

Min.Order:0 Metric Ton

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Type:Lab/Research institutions

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Synthetic route

C14H17NO6

C14H17NO6

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With ammonium hydroxide; tetrabutylammomium bromide for 0.0833333h; Time; Irradiation;99.2%
With ammonium hydroxide; tetrabutylammomium bromide In dichloromethane at 20℃; Reagent/catalyst;99.2%
With ammonium hydroxide; tetrabutylammomium bromide for 0.0833333h; Time; Sonication;99.2%
With ammonium hydroxide; tetrabutyl ammonium fluoride at 20℃; for 0.25h; Time; Sonication;99.2%
formamidine acetic acid
3473-63-0

formamidine acetic acid

ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
179688-27-8

ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Stage #1: formamidine acetic acid; ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate In butan-1-ol at 80℃; for 5h; Inert atmosphere;
Stage #2: In Isopropyl acetate for 1h; Reflux;
98%
In ethanol at 55℃; for 3h; Concentration; Temperature; Solvent; Green chemistry;98.5%
In 2-methoxy-ethanol at 125℃; for 8h;63.5%
6,7-di(2'-methoxyethoxy)quinazoline
1208902-93-5

6,7-di(2'-methoxyethoxy)quinazoline

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With peracetic acid; sulfuric acid In ethanol at 60℃; for 4h;93%
Stage #1: 6,7-di(2'-methoxyethoxy)quinazoline With ammonium cerium (IV) nitrate; acetic acid In water
Stage #2: With sodium hydroxide In water
88%
Methyl formate
107-31-3

Methyl formate

2-amino-4,5-bis-(2-methoxyethoxy)-benzoic acid methyl ester
476168-17-9

2-amino-4,5-bis-(2-methoxyethoxy)-benzoic acid methyl ester

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With ammonia In methanol for 7h; Concentration; Reflux;92%
formaldehyd
50-00-0

formaldehyd

2-amino-4,5-bis(2-methoxyethyloxy)benzamide
236750-62-2

2-amino-4,5-bis(2-methoxyethyloxy)benzamide

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
In water at 130℃; for 24h; Temperature;92%
tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

2-amino-4,5-bis(2-methoxyethyloxy)benzamide
236750-62-2

2-amino-4,5-bis(2-methoxyethyloxy)benzamide

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With chloro-trimethyl-silane In acetonitrile at 70℃;92%
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
179688-27-8

ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With ammonium formate In N,N-dimethyl-formamide at 160℃;79%
2-((6,7-bis(2-methoxyethoxy))-4-quinazolinylamino)-ethanol

2-((6,7-bis(2-methoxyethoxy))-4-quinazolinylamino)-ethanol

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With hydrogenchloride In water at 100 - 105℃; for 2h;71%
With hydrogenchloride In water at 100 - 105℃; for 2h;
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
179688-27-8

ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
In formamide at 160℃; for 3h;62%
C13H19NO5
1006377-63-4

C13H19NO5

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic anhydride / 110 °C
2.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
3.2: 81 percent / HCl / H2O / 90 - 130 °C
View Scheme
3,4-bis(2-methoxyethoxy) benzonitrile
80407-68-7

3,4-bis(2-methoxyethoxy) benzonitrile

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
2.2: 81 percent / HCl / H2O / 90 - 130 °C
View Scheme
Multi-step reaction with 4 steps
1: nitric acid
2: dihydrogen peroxide
3: palladium on activated charcoal; ammonium formate
4: water / 24 h / 130 °C
View Scheme
Multi-step reaction with 3 steps
1.1: nitric acid / dichloromethane / 12 h / 20 °C
2.1: pyrographite; iron(III) chloride; hydrazine hydrate / methanol / 4 h / Reflux
2.2: 12 h / Reflux
3.1: methanol / 8 h / Reflux
View Scheme
3,4-bis(2-methoxyethoxy)benzaldehyde
80407-64-3

3,4-bis(2-methoxyethoxy)benzaldehyde

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydroxylamine hydrochloride; pyridine / methanol / Heating
2.1: acetic anhydride / 110 °C
3.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
4.2: 81 percent / HCl / H2O / 90 - 130 °C
View Scheme
Multi-step reaction with 4 steps
1: nitric acid / water
2: hydrogenchloride; iron / ethanol
3: ethanol / Reflux
4: peracetic acid; sulfuric acid / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium permanganate; sodium hydroxide / water / 14.42 h / 0 - 40 °C
2: sulfuric acid / 5 h / 0 - 10 °C
3: nitric acid; sulfuric acid / chloroform / 1.5 h / 0 - 40 °C
4: iron; ammonium chloride; hydrogenchloride / water; ethanol / 15 h / 80 °C / Inert atmosphere
5: ammonia / methanol / 7 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: hydroxylamine hydrochloride; acetic anhydride
2: nitric acid
3: dihydrogen peroxide
4: palladium on activated charcoal; ammonium formate
5: water / 24 h / 130 °C
View Scheme
Multi-step reaction with 4 steps
1.1: formic acid; hydroxylamine hydrochloride; sodium formate / 8 h / 90 - 100 °C
2.1: nitric acid / dichloromethane / 12 h / 20 °C
3.1: pyrographite; iron(III) chloride; hydrazine hydrate / methanol / 4 h / Reflux
3.2: 12 h / Reflux
4.1: methanol / 8 h / Reflux
View Scheme
3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 98 percent / potassium carbonate / dimethylformamide / 100 °C
2.1: hydroxylamine hydrochloride; pyridine / methanol / Heating
3.1: acetic anhydride / 110 °C
4.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
5.2: 81 percent / HCl / H2O / 90 - 130 °C
View Scheme
Multi-step reaction with 6 steps
1: potassium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 105 - 110 °C / Inert atmosphere
2: potassium permanganate; sodium hydroxide / water / 14.42 h / 0 - 40 °C
3: sulfuric acid / 5 h / 0 - 10 °C
4: nitric acid; sulfuric acid / chloroform / 1.5 h / 0 - 40 °C
5: iron; ammonium chloride; hydrogenchloride / water; ethanol / 15 h / 80 °C / Inert atmosphere
6: ammonia / methanol / 7 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: sodium iodide / N,N-dimethyl-formamide / Reflux
2.1: formic acid; hydroxylamine hydrochloride; sodium formate / 8 h / 90 - 100 °C
3.1: nitric acid / dichloromethane / 12 h / 20 °C
4.1: pyrographite; iron(III) chloride; hydrazine hydrate / methanol / 4 h / Reflux
4.2: 12 h / Reflux
5.1: methanol / 8 h / Reflux
View Scheme
Ethyl protocatechuate
3943-89-3

Ethyl protocatechuate

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating
2: acetic acid; nitric acid / 24 h / 20 °C
3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
4: 84 percent / 12 h / 165 - 170 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate; tetrabutylammonium iodide / acetone
2: acetic acid; nitric acid / 24 h / 20 °C
3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
4: 84 percent / 12 h / 165 - 170 °C
View Scheme
Multi-step reaction with 4 steps
1: 68 percent / potassium carbonate; tetrabutylammonium iodide / acetone / 72 h / Heating
2: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C
3: 94 percent / hydrogen / palladium on activated carbon / methanol
4: 62 percent / formamide / 3 h / 160 °C
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; nitric acid / 24 h / 20 °C
2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
3: 84 percent / 12 h / 165 - 170 °C
View Scheme
Multi-step reaction with 3 steps
1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C
2: 94 percent / hydrogen / palladium on activated carbon / methanol
3: 62 percent / formamide / 3 h / 160 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid; nitric acid / 0 °C
2: hydrogen; palladium on activated charcoal / methanol
3: 165 - 170 °C
View Scheme
2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester
179688-26-7

2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
2: 84 percent / 12 h / 165 - 170 °C
View Scheme
Multi-step reaction with 2 steps
1: 94 percent / hydrogen / palladium on activated carbon / methanol
2: 62 percent / formamide / 3 h / 160 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen; palladium on activated charcoal / methanol
2: 165 - 170 °C
View Scheme
formamidine acetic acid
3473-63-0

formamidine acetic acid

2-amino-4,5-bis-(2-methoxyethoxy)-benzoic acid methyl ester
476168-17-9

2-amino-4,5-bis-(2-methoxyethoxy)-benzoic acid methyl ester

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
In 2-methoxy-ethanol for 24h; Heating / reflux;
In ethanol Reflux;
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

A

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

B

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline With pyridine In isopropyl alcohol at 80℃; for 1h;
Stage #2: With hydrogenchloride In 1,4-dioxane; diethyl ether; chloroform at 20℃; for 1h; Product distribution / selectivity;
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline With pyridine In isopropyl alcohol at 80℃; for 1h;
Stage #2: With hydrogenchloride In 1,4-dioxane; diethyl ether; chloroform at 20℃;
methyl 3,4-bis{[2-(methyloxy)ethyl]oxy}benzoate
179688-14-3

methyl 3,4-bis{[2-(methyloxy)ethyl]oxy}benzoate

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: nitric acid; acetic anhydride; acetic acid / acetic acid / 0 - 5 °C
2: hydrogen / ethanol
3: ethanol / Reflux
View Scheme
Multi-step reaction with 3 steps
1: nitric acid; sulfuric acid / chloroform / 1.5 h / 0 - 40 °C
2: iron; ammonium chloride; hydrogenchloride / water; ethanol / 15 h / 80 °C / Inert atmosphere
3: ammonia / methanol / 7 h / Reflux
View Scheme
methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate
501684-22-6

methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / ethanol
2: ethanol / Reflux
View Scheme
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
With oxalyl dichloride In chloroform; N,N-dimethyl-formamide for 1.5h; Heating;98%
With oxalyl dichloride In dichloromethane Solvent; Reagent/catalyst; Temperature; Reflux; Large scale;97%
With thionyl chloride In N,N-dimethyl-formamide at 60℃; Temperature; Concentration;95.6%
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

6,7-bis(2-methoxyethoxy)quinazoline-4(3H)-thione
958669-56-2

6,7-bis(2-methoxyethoxy)quinazoline-4(3H)-thione

Conditions
ConditionsYield
With pyridine; tetraphosphorus decasulfide for 15h; Reflux;97%
With tetraphosphorus decasulfide In pyridine for 24h; Heating;95%
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
for 3h; Temperature; Reflux; Large scale;95.1%
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

methanol
67-56-1

methanol

6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline
1312937-41-9

6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline

Conditions
ConditionsYield
Stage #1: 6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one With trichlorophosphate; N,N-dimethyl-formamide at 80℃; for 0.5h;
Stage #2: methanol With potassium carbonate In toluene at 0 - 40℃; for 0.5h; Product distribution / selectivity;
94%
Stage #1: 6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one With trichlorophosphate; N,N-dimethyl-formamide at 80℃; for 0.5h;
Stage #2: methanol With potassium carbonate In N,N-dimethyl-formamide; toluene at 0 - 40℃; Product distribution / selectivity;
94%
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