Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:3543-75-7
Min.Order:1 Kilogram
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inquiryItems Standard Result Appearance White or off-white powder,encounter light easy to change color White powder,encounter light easy to ch
Cas:3543-75-7
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:3543-75-7
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:3543-75-7
Min.Order:1 Gram
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Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
CAS RN.: 3543-75-7;97832-05-8 Molecular Weight: 394.7238 Molecular Formula:
Cas:3543-75-7
Min.Order:10 Kilogram
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Type:Trading Company
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:3543-75-7
Min.Order:1 Gram
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:3543-75-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryTIANFUCHEM--3543-75-7--Bendamustine hydrochloride factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable busines
Cas:3543-75-7
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:3543-75-7
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inquiryProduct Name Bendamustine hydrochloride CAS No. 3543-75-7 Molecular Formula C16H21Cl2N3O2.HCl Molecular Weight 394.72 Appearance White powde
Cas:3543-75-7
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:3543-75-7
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
Cas:3543-75-7
Min.Order:10 Gram
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Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:3543-75-7
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
Cas:3543-75-7
Min.Order:1 Gram
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:3543-75-7
Min.Order:1 Metric Ton
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Type:Trading Company
inquiryBendamustine hydrochloride CAS:3543-75-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
Cas:3543-75-7
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:3543-75-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:3543-75-7
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryAppearance:white to brown low melting crystallin. Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Comm
Cas:3543-75-7
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:3543-75-7
Min.Order:1 Gram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
inquiry≥98.5% Enterprise standard. Appearance:White to almost white crystalline powder Storage:Room temperature Package:as required Application:used in medicine Transportation:BY SEA BY AIR EXPRESS Port:China main port
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:3543-75-7
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:3543-75-7
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:3543-75-7
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:3543-75-7
Min.Order:0
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:3543-75-7
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:3543-75-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryBendamustine HydrochlorideAppearance:white to brown low melting crystallin. Storage:Store in a cool,dry place and keep away from direct strong light Package:according to customers' requirements Application:Used for research and industrial manufacture
bendamustine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water for 4h; Reflux; | 83% |
With hydrogenchloride; water at 40℃; for 2h; Product distribution / selectivity; | |
With hydrogenchloride In water at 25 - 28℃; for 0.25h; |
4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
bendamustine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester With thionyl chloride In dichloromethane at -1 - 22℃; for 17h; Stage #2: With hydrogenchloride In water at 75℃; | 76.2% |
Stage #1: 4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester With thionyl chloride In chloroform at 0 - 5℃; Stage #2: With hydrogenchloride; pyrographite In water at 30℃; Reflux; | 75% |
Stage #1: 4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester With thionyl chloride In chloroform at 0 - 25℃; Large scale; Stage #2: With hydrogenchloride In chloroform; water Large scale; | 75% |
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid methyl ester
bendamustine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride for 4h; Reflux; Large scale reaction; | 76% |
With hydrogenchloride; water for 4h; Reflux; | |
With hydrogenchloride In water at 25 - 28℃; for 0.25h; |
bendamustine isopropyl ester
bendamustine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; water at 35 - 40℃; for 1.5h; Product distribution / selectivity; | 75% |
isopropyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / water / 2 h / 70 - 75 °C 1.2: 1.5 h / 70 - 75 °C 2.1: thionyl chloride / dichloromethane / 7 h / 0 - 30 °C 3.1: hydrogenchloride; water / 1.5 h / 35 - 40 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C 2.1: thionyl chloride / dichloromethane / 2 h / 25 - 60 °C 2.2: 25 - 30 °C View Scheme |
4-(2,4-dinitrophenylcarbamoyl)butyric acid methyl ester
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / acetonitrile / 23 - 25 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 3: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction 4: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 23 - 25 °C 2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 2.2: 2 h / 60 - 65 °C 3.1: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction 4.1: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 23 - 25 °C 2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 2.2: 2 h / 60 - 65 °C 3.1: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction 4.1: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 4 steps 1: potassium carbonate / acetonitrile / 23 - 25 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 3: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction 4: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme |
4-[(2,4-dinitrophenyl)methylcarbamoyl]butyric acid methyl ester
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 2: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction 3: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 3 steps 1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 1.2: 2 h / 60 - 65 °C 2.1: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction 3.1: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 3 steps 1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 1.2: 2 h / 60 - 65 °C 2.1: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction 3.1: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 3 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 2: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction 3: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme |
4-(5-amino-1-methyl-1H-benzoimidazol-2-yl)butyric acid methyl ester hydrochloride
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction 2: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction 2: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: toluene / 6 h / 95 - 105 °C / Large scale reaction 2: potassium carbonate / acetonitrile / 23 - 25 °C 3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 4: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction 5: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 5 steps 1.1: toluene / 6 h / 95 - 105 °C / Large scale reaction 2.1: potassium carbonate / acetonitrile / 23 - 25 °C 3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 3.2: 2 h / 60 - 65 °C 4.1: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction 5.1: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 5 steps 1.1: toluene / 6 h / 95 - 105 °C / Large scale reaction 2.1: potassium carbonate / acetonitrile / 23 - 25 °C 3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 3.2: 2 h / 60 - 65 °C 4.1: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction 5.1: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 5 steps 1: toluene / 6 h / 95 - 105 °C / Large scale reaction 2: potassium carbonate / acetonitrile / 23 - 25 °C 3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 4: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction 5: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: toluene / 6 h / 95 - 105 °C / Large scale reaction 2: potassium carbonate / acetonitrile / 23 - 25 °C 3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 4: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction 5: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 5 steps 1.1: toluene / 6 h / 95 - 105 °C / Large scale reaction 2.1: potassium carbonate / acetonitrile / 23 - 25 °C 3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 3.2: 2 h / 60 - 65 °C 4.1: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction 5.1: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 5 steps 1.1: toluene / 6 h / 95 - 105 °C / Large scale reaction 2.1: potassium carbonate / acetonitrile / 23 - 25 °C 3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 3.2: 2 h / 60 - 65 °C 4.1: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction 5.1: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme | |
Multi-step reaction with 5 steps 1: toluene / 6 h / 95 - 105 °C / Large scale reaction 2: potassium carbonate / acetonitrile / 23 - 25 °C 3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction 4: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction 5: hydrogenchloride / 4 h / Reflux; Large scale reaction View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium sulfide; sodium hydrogencarbonate / water; methanol / 25 - 80 °C 2.1: 35 - 40 °C 2.2: 80 - 85 °C 2.3: 25 - 30 °C 3.1: hydrogen / Raney nickel / methanol / 25 - 30 °C / 4654.46 - 5171.62 Torr 4.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C 5.1: thionyl chloride / dichloromethane / 25 - 60 °C 5.2: 55 - 60 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium sulfide; sodium hydrogencarbonate / methanol; water / 25 - 80 °C 2.1: 35 - 40 °C 2.2: 35 - 85 °C / Reflux 3.1: hydrogen / methanol / 4654.46 - 5171.62 Torr / Autoclave 4.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C 5.1: thionyl chloride / dichloromethane / 2 h / 25 - 60 °C 5.2: 25 - 30 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: water; methanol / 0 - 30 °C 2.1: sodium sulfide; sodium hydrogencarbonate / water; methanol / 25 - 80 °C 3.1: 35 - 40 °C 3.2: 80 - 85 °C 3.3: 25 - 30 °C 4.1: hydrogen / Raney nickel / methanol / 25 - 30 °C / 4654.46 - 5171.62 Torr 5.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C 6.1: thionyl chloride / dichloromethane / 25 - 60 °C 6.2: 55 - 60 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: methanol; water 2.1: sodium sulfide; sodium hydrogencarbonate / methanol; water / 25 - 80 °C 3.1: 35 - 40 °C 3.2: 35 - 85 °C / Reflux 4.1: hydrogen / methanol / 4654.46 - 5171.62 Torr / Autoclave 5.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C 6.1: thionyl chloride / dichloromethane / 2 h / 25 - 60 °C 6.2: 25 - 30 °C View Scheme |
N1-methyl-4-nitrobenzene-1,2-diamine
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 35 - 40 °C 1.2: 80 - 85 °C 1.3: 25 - 30 °C 2.1: hydrogen / Raney nickel / methanol / 25 - 30 °C / 4654.46 - 5171.62 Torr 3.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C 4.1: thionyl chloride / dichloromethane / 25 - 60 °C 4.2: 55 - 60 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 35 - 40 °C 1.2: 35 - 85 °C / Reflux 2.1: hydrogen / methanol / 4654.46 - 5171.62 Torr / Autoclave 3.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C 4.1: thionyl chloride / dichloromethane / 2 h / 25 - 60 °C 4.2: 25 - 30 °C View Scheme |
isopropyl 4-(5-bis(2-hydroxyethyl)amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
bendamustine hydrochloride
Conditions | Yield |
---|---|
Stage #1: isopropyl 4-(5-bis(2-hydroxyethyl)amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate With thionyl chloride In dichloromethane at 25 - 60℃; Stage #2: With hydrogenchloride In water at 55 - 60℃; | |
Stage #1: isopropyl 4-(5-bis(2-hydroxyethyl)amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate With thionyl chloride In dichloromethane at 25 - 60℃; for 2h; Stage #2: With water In dichloromethane at 25 - 30℃; | 16.4 g |
isopropyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogen / Raney nickel / methanol / 25 - 30 °C / 4654.46 - 5171.62 Torr 2.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C 3.1: thionyl chloride / dichloromethane / 25 - 60 °C 3.2: 55 - 60 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogen / methanol / 4654.46 - 5171.62 Torr / Autoclave 2.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C 3.1: thionyl chloride / dichloromethane / 2 h / 25 - 60 °C 3.2: 25 - 30 °C View Scheme |
4-{5-[bis-(2-hydroxyethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-butanoic acid methyl ester
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trichlorophosphate / 0.25 h / Reflux 2: hydrogenchloride / water / 0.25 h / 25 - 28 °C View Scheme | |
Stage #1: 4-{5-[bis-(2-hydroxyethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-butanoic acid methyl ester With thionyl chloride In dichloromethane at 20 - 30℃; for 7h; Stage #2: With hydrogenchloride In dichloromethane at 20 - 70℃; |
4‐(1‐methyl‐5‐nitro‐1H‐benzoimidazol‐2‐yl)butyric acid ethyl ester
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: iron; hydrogenchloride; ammonium chloride / methanol; water / 2 h / 60 - 65 °C 2.1: sodium carbonate; sodium iodide / 65 - 70 °C 3.1: thionyl chloride / dichloromethane / 0 °C / Reflux 3.2: 80 - 90 °C View Scheme | |
Multi-step reaction with 4 steps 1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr 2: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale 3: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 4: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 4 steps 1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr 2: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5 3: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 4: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr 2.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5 3.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 3.2: 75 °C View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium carbonate; sodium iodide / 65 - 70 °C 2.1: thionyl chloride / dichloromethane / 0 °C / Reflux 2.2: 80 - 90 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale 2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 3: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5 2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 3: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5 2.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 2.2: 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetic acid / water / -5 - 0 °C 2: thionyl chloride / dichloromethane / 2 h / -5 - 20 °C 3: hydrogenchloride / water / 4 h / Reflux View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: toluene / 4 h / 70 - 85 °C 2.1: water / 3 h / 75 °C 2.2: 55 - 60 °C 3.1: sulfuric acid / 10 h / Reflux 4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr 5.1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale 6.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 7.1: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: toluene / 4 h / 70 - 85 °C 2.1: water / 3 h / 75 °C 2.2: 55 - 60 °C 3.1: sulfuric acid / 10 h / Reflux 4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr 5.1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5 6.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 7.1: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: hydrogenchloride / toluene / 4 h / 85 °C 1.2: 3 h / 75 °C 2.1: sulfuric acid / 10 h / Reflux 3.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr 4.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5 5.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 5.2: 75 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: toluene / 4 h / 70 - 85 °C 2.1: water / 3 h / 75 °C 2.2: 55 - 60 °C 3.1: sulfuric acid / 10 h / Reflux 4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr 5.1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale 6.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 7.1: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: toluene / 4 h / 70 - 85 °C 2.1: water / 3 h / 75 °C 2.2: 55 - 60 °C 3.1: sulfuric acid / 10 h / Reflux 4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr 5.1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5 6.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 7.1: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: hydrogenchloride / toluene / 4 h / 85 °C 1.2: 3 h / 75 °C 2.1: sulfuric acid / 10 h / Reflux 3.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr 4.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5 5.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 5.2: 75 °C View Scheme |
4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sulfuric acid / 10 h / Reflux 2: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr 3: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale 4: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 5: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 5 steps 1: sulfuric acid / 10 h / Reflux 2: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr 3: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5 4: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 5: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sulfuric acid / 10 h / Reflux 2.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr 3.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5 4.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 4.2: 75 °C View Scheme |
bendamustine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 40 - 75℃; | 225 g |
5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: water / 3 h / 75 °C 1.2: 55 - 60 °C 2.1: sulfuric acid / 10 h / Reflux 3.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr 4.1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale 5.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 6.1: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: water / 3 h / 75 °C 1.2: 55 - 60 °C 2.1: sulfuric acid / 10 h / Reflux 3.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr 4.1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5 5.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 6.1: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme |
1-aminodecane
bendamustine hydrochloride
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-N-decyl-butyramide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 2.7 - 10℃; for 1.5h; Inert atmosphere; | 100% |
1-dodecyl alcohol
bendamustine hydrochloride
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid dodecyl ester
Conditions | Yield |
---|---|
Stage #1: bendamustine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.733333h; Inert atmosphere; Stage #2: 1-dodecyl alcohol In dichloromethane for 0.183333h; Inert atmosphere; Stage #3: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 23.5h; Reagent/catalyst; | 98% |
Conditions | Yield |
---|---|
With methanesulfonic acid at 70℃; for 1h; Inert atmosphere; | 97% |
methanol
bendamustine hydrochloride
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid methyl ester
Conditions | Yield |
---|---|
With methanesulfonic acid at 65℃; for 1h; Inert atmosphere; | 94% |
bendamustine hydrochloride
bendamustine
Conditions | Yield |
---|---|
With triethylamine In methanol other reagent; | 89% |
1-Decanol
bendamustine hydrochloride
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid decyl ester
Conditions | Yield |
---|---|
Stage #1: bendamustine hydrochloride With triethylamine In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: 1-Decanol With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 20h; Reagent/catalyst; Time; Inert atmosphere; | 88.6% |
bendamustine hydrochloride
4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butan-1-ol
Conditions | Yield |
---|---|
With borane-THF In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 86% |
Conditions | Yield |
---|---|
With hydrogenchloride for 4h; Ambient temperature; | 85% |
bendamustine hydrochloride
Conditions | Yield |
---|---|
With 1-hydroxy-pyrrolidine-2,5-dione; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride for 12h; | 82.4% |
bendamustine hydrochloride
4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure-hydrochlorid
Conditions | Yield |
---|---|
With water at 95℃; for 5h; | 82% |
4-amino-1-((2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,3-difluoro-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
bendamustine hydrochloride
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 40℃; for 12h; | 79% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere; | 73% |
Conditions | Yield |
---|---|
Stage #1: bendamustine hydrochloride With triethylamine; dicyclohexyl-carbodiimide In chloroform at 0℃; for 0.5h; Stage #2: irinotecan With dmap In chloroform at 0 - 20℃; for 48h; Darkness; | 69% |
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxysulfosuccinimide sodium salt In water at 20℃; for 12.5h; | 66.1% |
L-alanine methyl ester hydrochloride
bendamustine hydrochloride
(S)-2-(4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyrylamino)propionic acid methyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 1.9 - 20℃; for 4h; Inert atmosphere; | 63.3% |
Conditions | Yield |
---|---|
Stage #1: bendamustine hydrochloride With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 5-Fluoro-2'-deoxyuridine With dmap; triethylamine In N,N-dimethyl-formamide at 25℃; for 48h; Darkness; | 61% |
tetradecylamine
bendamustine hydrochloride
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-N-tetradecyl-butyramide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 3.3 - 20℃; for 3h; Inert atmosphere; | 57.6% |
bendamustine hydrochloride
Lenalidomide
Conditions | Yield |
---|---|
With dmap; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 40℃; | 51% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; | 48.3% |
1-docosanol
bendamustine hydrochloride
4-{5-[bis-(chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}butyric acid docosyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere; | 43.1% |
rac-2-dodecanol
bendamustine hydrochloride
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid 2-dodecyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere; | 40% |
1-Tetradecanol
bendamustine hydrochloride
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid tetradecyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 20h; Inert atmosphere; | 36.4% |
bendamustine hydrochloride
cyclohexanol
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid cyclohexyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h; Inert atmosphere; | 27.9% |
decan-5-ol
bendamustine hydrochloride
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid 5-decyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In 1,2-dichloro-ethane at 75℃; for 120h; Inert atmosphere; | 24.2% |
bendamustine hydrochloride
A
4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure-hydrochlorid
B
4-(6-((2-chloroethyl)(2-hydroxyethyl)amino)-3-methylbenzimidazolyl(2))butyric acid hydrochloride
Conditions | Yield |
---|---|
With water at 95℃; for 1h; |
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