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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Bendamustine hydrochloride Manufacturer/High quality/Best price/In stock

Cas:3543-75-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or off-white powder,encounter light easy to change color White powder,encounter light easy to ch

Bendamustine Hydrochloride High purity CAS:3543-75-7

Cas:3543-75-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Bendamustine Hydrochloride supplier in China

Cas:3543-75-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Bendamustine hydrochloride 3543-75-7 with best price

Cas:3543-75-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Bendamustine Hydrochloride

Cas:3543-75-7

Min.Order:1

Negotiable

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

CAS RN.: 3543-75-7;97832-05-8 Molecular Weight: 394.7238 Molecular Formula:

Bendamustine hydrochloride 3543-75-7

Cas:3543-75-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Bendamustine hydrochloride 3543-75-7 GMP Manufacturer

Cas:3543-75-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Bendamustine hydrochloride

Cas:3543-75-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--3543-75-7--Bendamustine hydrochloride factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable busines

TIANFUCHEM--3543-75-7--Bendamustine hydrochloride factory price

Cas:3543-75-7

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 3543-75-7 with best quality

Cas:3543-75-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name Bendamustine hydrochloride CAS No. 3543-75-7 Molecular Formula C16H21Cl2N3O2.HCl Molecular Weight 394.72 Appearance White powde

Bendamustine hydrochloride CAS NO.: 3543-75-7

Cas:3543-75-7

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

3543-75-7 Bendamustine Hydrochloride

Cas:3543-75-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

99%min Bendamustine Hydrochloride 3543-75-7

Cas:3543-75-7

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Supply Anti-Cancer Pharmaceutical Grade API 99% CAS 3543-75-7 Bendamustine Hydrochloride Powder

Cas:3543-75-7

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Bendamustine hydrochloride

Cas:3543-75-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Bendamustine hydrochloride CAS NO. 3543-75-7

Cas:3543-75-7

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Bendamustine hydrochloride CAS:3543-75-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

Bendamustine hydrochloride CAS:3543-75-7

Cas:3543-75-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Bendamustine hydrochloride

Cas:3543-75-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:3543-75-7

Cas:3543-75-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Bendamustine Hydrochloride cas:3543-75-7

Cas:3543-75-7

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Triumph International Development Limilted

Appearance:white to brown low melting crystallin. Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Comm

Bendamustine Hydrochloride

Cas:3543-75-7

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Bendamustine hydrochloride

Cas:3543-75-7

Min.Order:1 Gram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

≥98.5% Enterprise standard. Appearance:White to almost white crystalline powder Storage:Room temperature Package:as required Application:used in medicine Transportation:BY SEA BY AIR EXPRESS Port:China main port

Bendamustine hydrochloride

Cas:3543-75-7

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

bendamustine hydrochloride 3543-75-7

Cas:3543-75-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Bendamustine?HCl

Cas:3543-75-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Bendamustine Hydrochloride CAS 3543-75-7

Cas:3543-75-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Bendamustine hydrochloride

Cas:3543-75-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-Bromo-1-cyclohexene

Cas:3543-75-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Bendamustine Hydrochloride

Cas:3543-75-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Bendamustine HydrochlorideAppearance:white to brown low melting crystallin. Storage:Store in a cool,dry place and keep away from direct strong light Package:according to customers' requirements Application:Used for research and industrial manufacture

Bendamustine Hydrochloride

Cas:3543-75-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Synthetic route

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water for 4h; Reflux;83%
With hydrogenchloride; water at 40℃; for 2h; Product distribution / selectivity;
With hydrogenchloride In water at 25 - 28℃; for 0.25h;
4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
3543-74-6

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Stage #1: 4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester With thionyl chloride In dichloromethane at -1 - 22℃; for 17h;
Stage #2: With hydrogenchloride In water at 75℃;
76.2%
Stage #1: 4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester With thionyl chloride In chloroform at 0 - 5℃;
Stage #2: With hydrogenchloride; pyrographite In water at 30℃; Reflux;
75%
Stage #1: 4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester With thionyl chloride In chloroform at 0 - 25℃; Large scale;
Stage #2: With hydrogenchloride In chloroform; water Large scale;
75%
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid methyl ester
109882-25-9

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid methyl ester

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride for 4h; Reflux; Large scale reaction;76%
With hydrogenchloride; water for 4h; Reflux;
With hydrogenchloride In water at 25 - 28℃; for 0.25h;
bendamustine isopropyl ester
1313020-25-5

bendamustine isopropyl ester

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water at 35 - 40℃; for 1.5h; Product distribution / selectivity;75%
isopropyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
1313020-26-6

isopropyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / water / 2 h / 70 - 75 °C
1.2: 1.5 h / 70 - 75 °C
2.1: thionyl chloride / dichloromethane / 7 h / 0 - 30 °C
3.1: hydrogenchloride; water / 1.5 h / 35 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C
2.1: thionyl chloride / dichloromethane / 2 h / 25 - 60 °C
2.2: 25 - 30 °C
View Scheme
4-(2,4-dinitrophenylcarbamoyl)butyric acid methyl ester
1221157-09-0

4-(2,4-dinitrophenylcarbamoyl)butyric acid methyl ester

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / acetonitrile / 23 - 25 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
3: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction
4: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 23 - 25 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
2.2: 2 h / 60 - 65 °C
3.1: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction
4.1: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 23 - 25 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
2.2: 2 h / 60 - 65 °C
3.1: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction
4.1: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / acetonitrile / 23 - 25 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
3: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction
4: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
4-[(2,4-dinitrophenyl)methylcarbamoyl]butyric acid methyl ester
1221157-10-3

4-[(2,4-dinitrophenyl)methylcarbamoyl]butyric acid methyl ester

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
2: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction
3: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
1.2: 2 h / 60 - 65 °C
2.1: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction
3.1: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
1.2: 2 h / 60 - 65 °C
2.1: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction
3.1: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
2: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction
3: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
4-(5-amino-1-methyl-1H-benzoimidazol-2-yl)butyric acid methyl ester hydrochloride
1221157-11-4

4-(5-amino-1-methyl-1H-benzoimidazol-2-yl)butyric acid methyl ester hydrochloride

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction
2: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 2 steps
1: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction
2: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
methyl 4-(chlorocarbonyl)butyrate
1501-26-4

methyl 4-(chlorocarbonyl)butyrate

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: toluene / 6 h / 95 - 105 °C / Large scale reaction
2: potassium carbonate / acetonitrile / 23 - 25 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
4: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction
5: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 5 steps
1.1: toluene / 6 h / 95 - 105 °C / Large scale reaction
2.1: potassium carbonate / acetonitrile / 23 - 25 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
3.2: 2 h / 60 - 65 °C
4.1: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction
5.1: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 5 steps
1.1: toluene / 6 h / 95 - 105 °C / Large scale reaction
2.1: potassium carbonate / acetonitrile / 23 - 25 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
3.2: 2 h / 60 - 65 °C
4.1: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction
5.1: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 5 steps
1: toluene / 6 h / 95 - 105 °C / Large scale reaction
2: potassium carbonate / acetonitrile / 23 - 25 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
4: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction
5: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
2,4-Dinitroanilin
97-02-9

2,4-Dinitroanilin

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: toluene / 6 h / 95 - 105 °C / Large scale reaction
2: potassium carbonate / acetonitrile / 23 - 25 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
4: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction
5: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 5 steps
1.1: toluene / 6 h / 95 - 105 °C / Large scale reaction
2.1: potassium carbonate / acetonitrile / 23 - 25 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
3.2: 2 h / 60 - 65 °C
4.1: sodium tetrahydroborate / 1,2-dichloro-ethane / 30 - 50 °C / Large scale reaction
5.1: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 5 steps
1.1: toluene / 6 h / 95 - 105 °C / Large scale reaction
2.1: potassium carbonate / acetonitrile / 23 - 25 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
3.2: 2 h / 60 - 65 °C
4.1: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction
5.1: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 5 steps
1: toluene / 6 h / 95 - 105 °C / Large scale reaction
2: potassium carbonate / acetonitrile / 23 - 25 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr / Large scale reaction
4: borane-THF / tetrahydrofuran / 30 - 50 °C / Large scale reaction
5: hydrogenchloride / 4 h / Reflux; Large scale reaction
View Scheme
N-methyl-2,4-dinitroaniline
2044-88-4

N-methyl-2,4-dinitroaniline

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium sulfide; sodium hydrogencarbonate / water; methanol / 25 - 80 °C
2.1: 35 - 40 °C
2.2: 80 - 85 °C
2.3: 25 - 30 °C
3.1: hydrogen / Raney nickel / methanol / 25 - 30 °C / 4654.46 - 5171.62 Torr
4.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C
5.1: thionyl chloride / dichloromethane / 25 - 60 °C
5.2: 55 - 60 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium sulfide; sodium hydrogencarbonate / methanol; water / 25 - 80 °C
2.1: 35 - 40 °C
2.2: 35 - 85 °C / Reflux
3.1: hydrogen / methanol / 4654.46 - 5171.62 Torr / Autoclave
4.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C
5.1: thionyl chloride / dichloromethane / 2 h / 25 - 60 °C
5.2: 25 - 30 °C
View Scheme
1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: water; methanol / 0 - 30 °C
2.1: sodium sulfide; sodium hydrogencarbonate / water; methanol / 25 - 80 °C
3.1: 35 - 40 °C
3.2: 80 - 85 °C
3.3: 25 - 30 °C
4.1: hydrogen / Raney nickel / methanol / 25 - 30 °C / 4654.46 - 5171.62 Torr
5.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C
6.1: thionyl chloride / dichloromethane / 25 - 60 °C
6.2: 55 - 60 °C
View Scheme
Multi-step reaction with 6 steps
1.1: methanol; water
2.1: sodium sulfide; sodium hydrogencarbonate / methanol; water / 25 - 80 °C
3.1: 35 - 40 °C
3.2: 35 - 85 °C / Reflux
4.1: hydrogen / methanol / 4654.46 - 5171.62 Torr / Autoclave
5.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C
6.1: thionyl chloride / dichloromethane / 2 h / 25 - 60 °C
6.2: 25 - 30 °C
View Scheme
N1-methyl-4-nitrobenzene-1,2-diamine
41939-61-1

N1-methyl-4-nitrobenzene-1,2-diamine

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 35 - 40 °C
1.2: 80 - 85 °C
1.3: 25 - 30 °C
2.1: hydrogen / Raney nickel / methanol / 25 - 30 °C / 4654.46 - 5171.62 Torr
3.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C
4.1: thionyl chloride / dichloromethane / 25 - 60 °C
4.2: 55 - 60 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 35 - 40 °C
1.2: 35 - 85 °C / Reflux
2.1: hydrogen / methanol / 4654.46 - 5171.62 Torr / Autoclave
3.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C
4.1: thionyl chloride / dichloromethane / 2 h / 25 - 60 °C
4.2: 25 - 30 °C
View Scheme
isopropyl 4-(5-bis(2-hydroxyethyl)amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
1313020-24-4

isopropyl 4-(5-bis(2-hydroxyethyl)amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Stage #1: isopropyl 4-(5-bis(2-hydroxyethyl)amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate With thionyl chloride In dichloromethane at 25 - 60℃;
Stage #2: With hydrogenchloride In water at 55 - 60℃;
Stage #1: isopropyl 4-(5-bis(2-hydroxyethyl)amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate With thionyl chloride In dichloromethane at 25 - 60℃; for 2h;
Stage #2: With water In dichloromethane at 25 - 30℃;
16.4 g
isopropyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate
1374784-01-6

isopropyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen / Raney nickel / methanol / 25 - 30 °C / 4654.46 - 5171.62 Torr
2.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C
3.1: thionyl chloride / dichloromethane / 25 - 60 °C
3.2: 55 - 60 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen / methanol / 4654.46 - 5171.62 Torr / Autoclave
2.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C
3.1: thionyl chloride / dichloromethane / 2 h / 25 - 60 °C
3.2: 25 - 30 °C
View Scheme
4-{5-[bis-(2-hydroxyethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-butanoic acid methyl ester
109882-31-7

4-{5-[bis-(2-hydroxyethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-butanoic acid methyl ester

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trichlorophosphate / 0.25 h / Reflux
2: hydrogenchloride / water / 0.25 h / 25 - 28 °C
View Scheme
Stage #1: 4-{5-[bis-(2-hydroxyethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-butanoic acid methyl ester With thionyl chloride In dichloromethane at 20 - 30℃; for 7h;
Stage #2: With hydrogenchloride In dichloromethane at 20 - 70℃;
4‐(1‐methyl‐5‐nitro‐1H‐benzoimidazol‐2‐yl)butyric acid ethyl ester
3543-72-4

4‐(1‐methyl‐5‐nitro‐1H‐benzoimidazol‐2‐yl)butyric acid ethyl ester

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: iron; hydrogenchloride; ammonium chloride / methanol; water / 2 h / 60 - 65 °C
2.1: sodium carbonate; sodium iodide / 65 - 70 °C
3.1: thionyl chloride / dichloromethane / 0 °C / Reflux
3.2: 80 - 90 °C
View Scheme
Multi-step reaction with 4 steps
1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
2: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale
3: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
4: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 4 steps
1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
2: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5
3: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
4: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
2.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
3.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
3.2: 75 °C
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium carbonate; sodium iodide / 65 - 70 °C
2.1: thionyl chloride / dichloromethane / 0 °C / Reflux
2.2: 80 - 90 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale
2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
3: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5
2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
3: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
2.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
2.2: 75 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid / water / -5 - 0 °C
2: thionyl chloride / dichloromethane / 2 h / -5 - 20 °C
3: hydrogenchloride / water / 4 h / Reflux
View Scheme
6-fluoro-3-nitroaniline
369-36-8

6-fluoro-3-nitroaniline

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: toluene / 4 h / 70 - 85 °C
2.1: water / 3 h / 75 °C
2.2: 55 - 60 °C
3.1: sulfuric acid / 10 h / Reflux
4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
5.1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale
6.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
7.1: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 7 steps
1.1: toluene / 4 h / 70 - 85 °C
2.1: water / 3 h / 75 °C
2.2: 55 - 60 °C
3.1: sulfuric acid / 10 h / Reflux
4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
5.1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5
6.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
7.1: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride / toluene / 4 h / 85 °C
1.2: 3 h / 75 °C
2.1: sulfuric acid / 10 h / Reflux
3.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
4.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
5.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
5.2: 75 °C
View Scheme
glutaric anhydride,
108-55-4

glutaric anhydride,

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: toluene / 4 h / 70 - 85 °C
2.1: water / 3 h / 75 °C
2.2: 55 - 60 °C
3.1: sulfuric acid / 10 h / Reflux
4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
5.1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale
6.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
7.1: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 7 steps
1.1: toluene / 4 h / 70 - 85 °C
2.1: water / 3 h / 75 °C
2.2: 55 - 60 °C
3.1: sulfuric acid / 10 h / Reflux
4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
5.1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5
6.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
7.1: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride / toluene / 4 h / 85 °C
1.2: 3 h / 75 °C
2.1: sulfuric acid / 10 h / Reflux
3.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
4.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
5.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
5.2: 75 °C
View Scheme
4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid
31349-48-1

4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sulfuric acid / 10 h / Reflux
2: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
3: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale
4: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
5: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 5 steps
1: sulfuric acid / 10 h / Reflux
2: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
3: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5
4: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
5: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sulfuric acid / 10 h / Reflux
2.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
3.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
4.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
4.2: 75 °C
View Scheme
bendamustine hydrochloride

bendamustine hydrochloride

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 40 - 75℃;225 g
5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid
451459-95-3

5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: water / 3 h / 75 °C
1.2: 55 - 60 °C
2.1: sulfuric acid / 10 h / Reflux
3.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
4.1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale
5.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
6.1: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 6 steps
1.1: water / 3 h / 75 °C
1.2: 55 - 60 °C
2.1: sulfuric acid / 10 h / Reflux
3.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
4.1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5
5.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
6.1: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
1-aminodecane
2016-57-1

1-aminodecane

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-N-decyl-butyramide
1609623-14-4

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-N-decyl-butyramide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 2.7 - 10℃; for 1.5h; Inert atmosphere;100%
1-dodecyl alcohol
112-53-8

1-dodecyl alcohol

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid dodecyl ester
1456608-94-8

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid dodecyl ester

Conditions
ConditionsYield
Stage #1: bendamustine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.733333h; Inert atmosphere;
Stage #2: 1-dodecyl alcohol In dichloromethane for 0.183333h; Inert atmosphere;
Stage #3: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 23.5h; Reagent/catalyst;
98%
ethanol
64-17-5

ethanol

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester

Conditions
ConditionsYield
With methanesulfonic acid at 70℃; for 1h; Inert atmosphere;97%
methanol
67-56-1

methanol

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid methyl ester
109882-25-9

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid methyl ester

Conditions
ConditionsYield
With methanesulfonic acid at 65℃; for 1h; Inert atmosphere;94%
bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
With triethylamine In methanol other reagent;89%
1-Decanol
112-30-1

1-Decanol

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid decyl ester
1609623-04-2

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid decyl ester

Conditions
ConditionsYield
Stage #1: bendamustine hydrochloride With triethylamine In dichloromethane at 20℃; for 0.25h; Inert atmosphere;
Stage #2: 1-Decanol With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 20h; Reagent/catalyst; Time; Inert atmosphere;
88.6%
bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butan-1-ol
1221157-14-7

4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butan-1-ol

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 0 - 20℃; Inert atmosphere;86%
ethanol
64-17-5

ethanol

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

bendamustine hydrochloride

bendamustine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride for 4h; Ambient temperature;85%
bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

bendamustine hydrazide

bendamustine hydrazide

Conditions
ConditionsYield
With 1-hydroxy-pyrrolidine-2,5-dione; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride for 12h;82.4%
bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure-hydrochlorid
109882-29-3

4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure-hydrochlorid

Conditions
ConditionsYield
With water at 95℃; for 5h;82%
4-amino-1-((2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,3-difluoro-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
688009-09-8

4-amino-1-((2R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,3-difluoro-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-(1-((2R,4R,5R)- 4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,3-difluorotetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-butanamide

4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-(1-((2R,4R,5R)- 4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3,3-difluorotetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-butanamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 40℃; for 12h;79%
1-octadecanol
112-92-5

1-octadecanol

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

C34H57Cl2N3O2
1609623-08-6

C34H57Cl2N3O2

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere;73%
bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

C49H57Cl2N7O7

C49H57Cl2N7O7

Conditions
ConditionsYield
Stage #1: bendamustine hydrochloride With triethylamine; dicyclohexyl-carbodiimide In chloroform at 0℃; for 0.5h;
Stage #2: irinotecan With dmap In chloroform at 0 - 20℃; for 48h; Darkness;
69%
acetic acid hydrazide
1068-57-1

acetic acid hydrazide

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

C18H25Cl2N5O2

C18H25Cl2N5O2

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxysulfosuccinimide sodium salt In water at 20℃; for 12.5h;66.1%
L-alanine methyl ester hydrochloride
2491-20-5

L-alanine methyl ester hydrochloride

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

(S)-2-(4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyrylamino)propionic acid methyl ester
1609623-17-7

(S)-2-(4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyrylamino)propionic acid methyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 1.9 - 20℃; for 4h; Inert atmosphere;63.3%
bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

C25H30Cl2FN5O6

C25H30Cl2FN5O6

Conditions
ConditionsYield
Stage #1: bendamustine hydrochloride With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: 5-Fluoro-2'-deoxyuridine With dmap; triethylamine In N,N-dimethyl-formamide at 25℃; for 48h; Darkness;
61%
tetradecylamine
2016-42-4

tetradecylamine

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-N-tetradecyl-butyramide
1609623-15-5

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}-N-tetradecyl-butyramide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 3.3 - 20℃; for 3h; Inert atmosphere;57.6%
bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-4-yl)butanamide

4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-4-yl)butanamide

Conditions
ConditionsYield
With dmap; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 40℃;51%
5-hydroxymicheliolide

5-hydroxymicheliolide

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

C31H39Cl2N3O5

C31H39Cl2N3O5

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;48.3%
1-docosanol
661-19-8

1-docosanol

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-{5-[bis-(chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}butyric acid docosyl ester
1609623-09-7

4-{5-[bis-(chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}butyric acid docosyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere;43.1%
rac-2-dodecanol
10203-28-8

rac-2-dodecanol

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid 2-dodecyl ester
1609623-10-0

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid 2-dodecyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere;40%
1-Tetradecanol
112-72-1

1-Tetradecanol

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid tetradecyl ester
1609623-05-3

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid tetradecyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 20h; Inert atmosphere;36.4%
bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

cyclohexanol
108-93-0

cyclohexanol

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid cyclohexyl ester
1609623-12-2

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid cyclohexyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h; Inert atmosphere;27.9%
decan-5-ol
5205-34-5

decan-5-ol

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid 5-decyl ester
1609623-11-1

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid 5-decyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In 1,2-dichloro-ethane at 75℃; for 120h; Inert atmosphere;24.2%
bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

A

4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure-hydrochlorid
109882-29-3

4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure-hydrochlorid

B

4-(6-((2-chloroethyl)(2-hydroxyethyl)amino)-3-methylbenzimidazolyl(2))butyric acid hydrochloride
109882-26-0

4-(6-((2-chloroethyl)(2-hydroxyethyl)amino)-3-methylbenzimidazolyl(2))butyric acid hydrochloride

Conditions
ConditionsYield
With water at 95℃; for 1h;
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