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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

Bendamustine

Cas:16506-27-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Bendamustine 16506-27-7 GMP manufacturer

Cas:16506-27-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 16506-27-7 with best quality

Cas:16506-27-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

16506-27-7 Bendamustine

Cas:16506-27-7

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Best quality Bendamustine 16506-27-7 with best price

Cas:16506-27-7

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Benzimidazole-2-butanoicacid, 5-[bis(2-chloroethyl)amino]-1-methyl- 16506-27-7

Cas:16506-27-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Benzimidazole-2-butanoicacid, 5-[bis(2-chloroethyl)amino]-1-methyl-

Cas:16506-27-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Bendamustine cas:16506-27-7

Cas:16506-27-7

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Benzimidazole-2-butanoicacid, 5-[bis(2-chloroethyl)amino]-1-methyl-

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,DHL/TNT/FEdex/UPS/EMS Port:QI

Bendamustine

Cas:16506-27-7

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

BENDAMUSTINE

Cas:16506-27-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1H-Benzimidazole-2-butanoicacid, 5-[bis(2-chloroethyl)amino]-1-methyl-

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

16506-27-7 Bendamustine

Cas:16506-27-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

Bendamustine 16506-27-7

Cas:16506-27-7

Min.Order:0 Metric Ton

Negotiable

Type:Other

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

16506-27-7 CAS NO.16506-27-7

Cas:16506-27-7

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Bendamustine

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Product Name: Bendamustine Synonyms: 5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid;5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid;Bendamustine CAS: 16506-27…Appearance:Solid powder Storage:Sealed,light and

Bendamustine

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

1H-Benzimidazole-2-butanoicacid, 5-[bis(2-chloroethyl)amino]-1-methyl-

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Bendamustine

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Bendamustine

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1H-Benzimidazole-2-butanoicacid, 5-[bis(2-chloroethyl)amino]-1-methyl-

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Bendamustine Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

High purity Bendamustine supplier

Cas:16506-27-7

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

16506-27-7

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

Bendamustine

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Bendamustine

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

16506-27-7 Application:intermediate

5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

16506-27-7

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Bendamustine 16506-27-7

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Bendamustine 16506-27-7

Cas:16506-27-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
With triethylamine In methanol other reagent;89%
4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
3543-74-6

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
With thionyl chloride In dichloromethane at 5 - 20℃; for 16h;73%
4-{5-[bis(2-chloro-ethyl)amino]-1-methyl-2-benzimidazolyl}butyric acid hydrochloride

4-{5-[bis(2-chloro-ethyl)amino]-1-methyl-2-benzimidazolyl}butyric acid hydrochloride

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
With sodium hydroxide In water
4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
Stage #1: 4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester With water Alkaline conditions;
Stage #2: With hydrogenchloride In water pH=~ 6 - ~ 7;
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
2: thionyl chloride / dichloromethane / 16 h / 5 - 20 °C
View Scheme
6-fluoro-3-nitroaniline
369-36-8

6-fluoro-3-nitroaniline

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / toluene / 4 h / 85 °C
1.2: 3 h / 75 °C
2.1: sulfuric acid / 10 h / Reflux
3.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
4.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
5.1: thionyl chloride / dichloromethane / 16 h / 5 - 20 °C
View Scheme
glutaric anhydride,
108-55-4

glutaric anhydride,

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / toluene / 4 h / 85 °C
1.2: 3 h / 75 °C
2.1: sulfuric acid / 10 h / Reflux
3.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
4.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
5.1: thionyl chloride / dichloromethane / 16 h / 5 - 20 °C
View Scheme
4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid
31349-48-1

4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid / 10 h / Reflux
2: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
3: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
4: thionyl chloride / dichloromethane / 16 h / 5 - 20 °C
View Scheme
4‐(1‐methyl‐5‐nitro‐1H‐benzoimidazol‐2‐yl)butyric acid ethyl ester
3543-72-4

4‐(1‐methyl‐5‐nitro‐1H‐benzoimidazol‐2‐yl)butyric acid ethyl ester

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
2: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
3: thionyl chloride / dichloromethane / 16 h / 5 - 20 °C
View Scheme
bendamustine
16506-27-7

bendamustine

4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butan-1-ol
1221157-14-7

4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butan-1-ol

Conditions
ConditionsYield
Stage #1: bendamustine With borane-THF In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #2: With water In tetrahydrofuran at 0℃;
86%
1-Tetradecanol
112-72-1

1-Tetradecanol

bendamustine
16506-27-7

bendamustine

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid tetradecyl ester
1609623-05-3

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid tetradecyl ester

Conditions
ConditionsYield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 27℃; Inert atmosphere;83.4%
2-(morpholin-4-yl)ethanol
622-40-2

2-(morpholin-4-yl)ethanol

bendamustine
16506-27-7

bendamustine

2-morpholinoethyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

2-morpholinoethyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h;82%
bendamustine
16506-27-7

bendamustine

A

4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure
109882-30-6

4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure

B

4-[5-[(2-chloroethyl)-(2-hydroxy-ethyl)amino]-1-methyl-benzimidazo-2-yl]-butanoic acid
109882-27-1

4-[5-[(2-chloroethyl)-(2-hydroxy-ethyl)amino]-1-methyl-benzimidazo-2-yl]-butanoic acid

Conditions
ConditionsYield
With water at 37℃; for 8h;A 81.6%
B 14.7%
With water at 37℃; for 2h;A 18.8%
B 36.8%
ciprofloxacin
85721-33-1

ciprofloxacin

bendamustine
16506-27-7

bendamustine

C33H37Cl2FN6O4*ClH
1318338-83-8

C33H37Cl2FN6O4*ClH

Conditions
ConditionsYield
Stage #1: bendamustine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.25h;
Stage #2: ciprofloxacin In dichloromethane at 20℃; for 1h;
73%
C19H32N4O6
1297582-71-8

C19H32N4O6

bendamustine
16506-27-7

bendamustine

C51H70Cl4N10O8

C51H70Cl4N10O8

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 25h; Steglich reaction;72.5%
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione
1585-90-6

1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

bendamustine
16506-27-7

bendamustine

2-{4-[6-bis(2-chloroethyl)amino-3-methylbenzo[d]imidazol-2-yl]butanoyl}oxyethylmaleimide
1297582-82-1

2-{4-[6-bis(2-chloroethyl)amino-3-methylbenzo[d]imidazol-2-yl]butanoyl}oxyethylmaleimide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 25h; Steglich reaction;70.1%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Steglich reaction;
With O-[(cyano(ethoxycarbonyl)methylidene)amino]-1,1,3,3-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Inert atmosphere;1.08 g
bendamustine
16506-27-7

bendamustine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

C25H30Cl2FN5O6

C25H30Cl2FN5O6

Conditions
ConditionsYield
Stage #1: 5-Fluoro-2'-deoxyuridine With dmap; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 0.25h; Inert atmosphere;
Stage #2: bendamustine In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere;
69%
(5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
117507-84-3

(5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

bendamustine
16506-27-7

bendamustine

4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}-N-[(10S,11S,15R,16R)-16-(4-hydroxy-3,5-dimethoxyphenyl)-14-oxo-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1,3(7),8-trien-10-yl]butanamide

4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}-N-[(10S,11S,15R,16R)-16-(4-hydroxy-3,5-dimethoxyphenyl)-14-oxo-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1,3(7),8-trien-10-yl]butanamide

Conditions
ConditionsYield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; Inert atmosphere;65%
1-dodecyl alcohol
112-53-8

1-dodecyl alcohol

bendamustine
16506-27-7

bendamustine

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid dodecyl ester
1456608-94-8

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid dodecyl ester

Conditions
ConditionsYield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20 - 27℃; Inert atmosphere;59%
C24H42N4O6
1297582-73-0

C24H42N4O6

bendamustine
16506-27-7

bendamustine

C56H80Cl4N10O8

C56H80Cl4N10O8

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 25h; Steglich reaction;56.7%
13-(2-hydroxy)ethoxymatrine

13-(2-hydroxy)ethoxymatrine

bendamustine
16506-27-7

bendamustine

13-[2-(4-[5-[bis-(2-chloroethyl)amino]-1-methyl-2-benzoimidazole]butyrate)ethoxy]matrine

13-[2-(4-[5-[bis-(2-chloroethyl)amino]-1-methyl-2-benzoimidazole]butyrate)ethoxy]matrine

Conditions
ConditionsYield
With sulfuric acid In toluene at 125 - 130℃; for 5.5h;53%
N-[(10S,11S,15R,16R)-16-(4-hydroxy-3,5-dimethoxyphenyl)-14-oxo-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1,3(7),8-trien-10-yl]-2-(piperazin-1-yl)acetamide

N-[(10S,11S,15R,16R)-16-(4-hydroxy-3,5-dimethoxyphenyl)-14-oxo-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1,3(7),8-trien-10-yl]-2-(piperazin-1-yl)acetamide

bendamustine
16506-27-7

bendamustine

2-[4-(4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}butanoyl)piperazin-1-yl]-N-[(10S,11S,15R,16R)-16-(4-hydroxy-3,5-dimethoxyphenyl)-14-oxo-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1,3(7),8-trien-10-yl]acetamide

2-[4-(4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}butanoyl)piperazin-1-yl]-N-[(10S,11S,15R,16R)-16-(4-hydroxy-3,5-dimethoxyphenyl)-14-oxo-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1,3(7),8-trien-10-yl]acetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; Inert atmosphere;52%
13-(2-amino)ethoxymatrine

13-(2-amino)ethoxymatrine

bendamustine
16506-27-7

bendamustine

13-[2-(4-{5-[bis-(2-chloroethyl)amino]-1-methyl-2-benzimidazolyl}butylacetamido)ethoxy]matrine

13-[2-(4-{5-[bis-(2-chloroethyl)amino]-1-methyl-2-benzimidazolyl}butylacetamido)ethoxy]matrine

Conditions
ConditionsYield
Stage #1: bendamustine With thionyl chloride In dichloromethane for 1h; Reflux;
Stage #2: 13-(2-amino)ethoxymatrine With potassium carbonate In chloroform for 22h; Reflux;
51%
bendamustine
16506-27-7

bendamustine

1,3,5-tris(3-aminopropyl)benzene

1,3,5-tris(3-aminopropyl)benzene

1,3,5-tris{3-{{4-[6-bis(2-chloroethyl)amino-3-methylbenzo[d]imidazol-2-yl]butanoyl}amino}propyl}benzene

1,3,5-tris{3-{{4-[6-bis(2-chloroethyl)amino-3-methylbenzo[d]imidazol-2-yl]butanoyl}amino}propyl}benzene

Conditions
ConditionsYield
Stage #1: bendamustine With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In dichloromethane; N,N-dimethyl-formamide at -20 - 20℃;
Stage #2: 1,3,5-tris(3-aminopropyl)benzene With N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at -20 - 20℃; for 20h;
42%
hydroxymethylparthenolide
93930-15-5

hydroxymethylparthenolide

bendamustine
16506-27-7

bendamustine

((1aR,7aS,10aS,10bS,E)-1a-methyl-8-methylene-9-oxo-1a,2,3,6,7,7a,8,9,10a,10b-decahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-5-yl)methyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

((1aR,7aS,10aS,10bS,E)-1a-methyl-8-methylene-9-oxo-1a,2,3,6,7,7a,8,9,10a,10b-decahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-5-yl)methyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 20℃;40%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 4h;39.7%
4-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)but-3-yn-1-yl methyl(2-(methylamino)ethyl)carbamate trifluoroacetate

4-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)but-3-yn-1-yl methyl(2-(methylamino)ethyl)carbamate trifluoroacetate

bendamustine
16506-27-7

bendamustine

4-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)but-3-yn-1-yl (2-(4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-methylbutanamido)ethyl)(methyl)carbamate

4-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)but-3-yn-1-yl (2-(4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-methylbutanamido)ethyl)(methyl)carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;38%
C20H34N4O6
1297582-72-9

C20H34N4O6

bendamustine
16506-27-7

bendamustine

C52H72Cl4N10O8

C52H72Cl4N10O8

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 25h; Steglich reaction;35%
sophora acid ethyl ester
109905-27-3

sophora acid ethyl ester

bendamustine
16506-27-7

bendamustine

C33H49Cl2N5O3

C33H49Cl2N5O3

Conditions
ConditionsYield
Stage #1: bendamustine With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 0.25h;
Stage #2: sophora acid ethyl ester With dmap In tetrahydrofuran at 20℃; for 48h;
32%
C18H30N4O6
1297582-69-4

C18H30N4O6

bendamustine
16506-27-7

bendamustine

C50H68Cl4N10O8

C50H68Cl4N10O8

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 25h; Steglich reaction;23.73%
bendamustine
16506-27-7

bendamustine

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid methyl ester
109882-25-9

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid methyl ester

Conditions
ConditionsYield
In methanol
1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione
1585-90-6

1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione

bendamustine
16506-27-7

bendamustine

A

C22H28N4O6
1247136-75-9

C22H28N4O6

B

C22H27ClN4O5
1247136-74-8

C22H27ClN4O5

C

4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure
109882-30-6

4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure

D

4-[5-[(2-chloroethyl)-(2-hydroxy-ethyl)amino]-1-methyl-benzimidazo-2-yl]-butanoic acid
109882-27-1

4-[5-[(2-chloroethyl)-(2-hydroxy-ethyl)amino]-1-methyl-benzimidazo-2-yl]-butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 25 h / 20 °C
2: water / 8 h / 37 °C
View Scheme
bendamustine
16506-27-7

bendamustine

4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure
109882-30-6

4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure

Conditions
ConditionsYield
With water at 37℃; for 2h; pH=7.4; aq. phosphate buffer;
bendamustine
16506-27-7

bendamustine

4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanal
1376614-94-6

4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanal

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
1.2: 0 °C
2.1: Dess-Martin periodane / dichloromethane / 20 °C
View Scheme

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