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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ethyl 4-(5-Amino-1-Methyl-1H-Benzo[D]Imidazol-2-Yl]Butanoate supplier in China

Cas:3543-73-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/925.html Product Name 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:1 Gram

FOB Price: $43.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

Bendamustine HCl[CAS:3543-75-7] Ethyl 4-(1-Methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate[CAS:3543-72-4] Ethyl 4-(1-Methyl-5-amino-1H-benzo[d]imidazol-2-yl)butanoate[CAS:3543-73-5] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an int

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

5-aMino-1-Methyl-2-BenziMidazolebutyric acid ethyl ester

Cas:3543-73-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

4-(5-amino-1-methyl-1H-benzoimidazol-2-yl)-butyric acid ethyl ester

Cas:3543-73-5

Min.Order:0

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

img _fcksavedurl="/UserAppearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:It is an important raw material and intermediate used in Organic Synthesis, Phar

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-(5-Amino-1-methyl-1H-benzoimidazol-2-yl)-butyric acid ethyl ester

Cas:3543-73-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--3543-73-5--1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China An

TIANFUCHEM--3543-73-5--1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester factory price

Cas:3543-73-5

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 3543-73-5 with best quality

Cas:3543-73-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

1-Methyl-5-amino-1H-benzimidazole-2- butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:10 Kilogram

FOB Price: $180.0 / 200.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Synonyms 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester;butanoic acid ethyl ester CAS: 354

1-Methyl-5-amino-1H-benzimidazole-2-butanoic Acid Ethyl Ester,CAS:3543-73-

Cas:3543-73-5

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester CAS 3543-73-5

Cas:3543-73-5

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 3543-73-5

Cas:3543-73-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:1 Kilogram

FOB Price: $900.0 / 1000.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester CAS:3543-73-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, s

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester CAS:3543-73-5

Cas:3543-73-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

ethyl 4-(5-amino-1-methylbenzimidazol-2-yl)butanoate cas:3543-73-5

Cas:3543-73-5

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl 4-(5-Amino-1-Methyl-1H-Benzo[D]Imidazol-2-Yl]Butanoate

Cas:3543-73-5

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai

3543-73-5

Cas:3543-73-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

1-METHYL-5-AMINO-1H-BENZIMIDAZOLE-2-BUTANOIC ACID ETHYLESTER

Cas:3543-73-5

Min.Order:1 Kilogram

FOB Price: $90.0 / 100.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1-Methyl-5-amino-1H-benzimidazole-2- butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

Cas:3543-73-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Ethyl 4-(5-Amino-1-Methyl-1H-Benzo[D]Imidazol-2-Yl]Butanoate

Cas:3543-73-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

4‐(1‐methyl‐5‐nitro‐1H‐benzoimidazol‐2‐yl)butyric acid ethyl ester
3543-72-4

4‐(1‐methyl‐5‐nitro‐1H‐benzoimidazol‐2‐yl)butyric acid ethyl ester

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol; ethyl acetate at 20℃; for 16h;98.3%
With 5% Pd/C-iron; hydrogen In ethanol under 3000.3 Torr;87.5%
With 5%-palladium/activated carbon; hydrogen In methanol; acetic acid at 25℃; under 750.075 - 1500.15 Torr; for 15h;77.8%
6-fluoro-3-nitroaniline
369-36-8

6-fluoro-3-nitroaniline

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / toluene / 4 h / 85 °C
1.2: 3 h / 75 °C
2.1: sulfuric acid / 10 h / Reflux
3.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 4 h / 70 - 85 °C
2.1: water / 3 h / 75 °C
2.2: 55 - 60 °C
3.1: sulfuric acid / 10 h / Reflux
4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
View Scheme
glutaric anhydride,
108-55-4

glutaric anhydride,

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / toluene / 4 h / 85 °C
1.2: 3 h / 75 °C
2.1: sulfuric acid / 10 h / Reflux
3.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 4 h / 70 - 85 °C
2.1: water / 3 h / 75 °C
2.2: 55 - 60 °C
3.1: sulfuric acid / 10 h / Reflux
4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
View Scheme
4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid
31349-48-1

4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid / 10 h / Reflux
2: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr
View Scheme
5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid
451459-95-3

5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: water / 3 h / 75 °C
1.2: 55 - 60 °C
2.1: sulfuric acid / 10 h / Reflux
3.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl‐4,6‐d2)butanoic‐2,2,4,4‐d4 acid hydrochloride

4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl‐4,6‐d2)butanoic‐2,2,4,4‐d4 acid hydrochloride

Conditions
ConditionsYield
With water; water-d2; hydrogen chloride at 180℃; for 1.5h; Microwave irradiation; Sealed tube;93.5%
2,4-dinitrobenzoyl chloride
20195-22-6

2,4-dinitrobenzoyl chloride

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

ethyl 4-(5-(2,4-dinitrobenzamido)-1-methyl-1H-benzimidazol-2-yl)butanoate
1227860-30-1

ethyl 4-(5-(2,4-dinitrobenzamido)-1-methyl-1H-benzimidazol-2-yl)butanoate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;83%
benzyl bromide
100-39-0

benzyl bromide

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

ethyl 4-(5-(dibenzylamino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

ethyl 4-(5-(dibenzylamino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 25℃; for 24h;82.9%
oxirane
75-21-8

oxirane

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
3543-74-6

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester

Conditions
ConditionsYield
Stage #1: oxirane; ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate With sodium acetate trihydrate In water; acetic acid at 0 - 25℃; for 23h;
Stage #2: With potassium carbonate In dichloromethane at 20 - 25℃;
78.53%
With acetic acid In water at -5 - 0℃;78.5%
Stage #1: ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate With acetic acid In water at 0 - 5℃;
Stage #2: oxirane In water at 0 - 20℃; for 1.5h;
oxirene
157-18-6

oxirene

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
3543-74-6

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester

Conditions
ConditionsYield
With sodium acetate; acetic acid In water at 0 - 25℃; for 23h; Concentration; Temperature; Time; Reagent/catalyst; Solvent;78.53%
2-(2-bromoethoxy)ethan-1-ol
57641-66-4

2-(2-bromoethoxy)ethan-1-ol

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

C18H27N3O4

C18H27N3O4

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 85℃;66%
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

2-bromoethanol
540-51-2

2-bromoethanol

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
3543-74-6

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester

Conditions
ConditionsYield
With calcium carbonate In acetonitrile at 80 - 90℃;56.3%
With potassium carbonate In water at 69 - 70℃; for 13.5h; pH=4.2 - 5.5; Large scale;343.5 g
With diammonium phosphate; potassium iodide In water at 65 - 70℃; pH=4.2 - 5.5; Reagent/catalyst; pH-value; Temperature;17.2 g
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

2-chloro-ethanol
107-07-3

2-chloro-ethanol

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
3543-74-6

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester

Conditions
ConditionsYield
With sodium carbonate; sodium iodide at 20 - 70℃;
With sodium carbonate; sodium iodide at 65 - 70℃;10 g
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

lithium 4-[1-methyl-5-bis-(2-chloroethyl)-benzimidazolyl-2] butanoate

lithium 4-[1-methyl-5-bis-(2-chloroethyl)-benzimidazolyl-2] butanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium acetate; acetic acid / water / 23 h / 0 - 25 °C
2: thionyl chloride / dichloromethane / 6 h / Reflux
3: lithium hydroxide / water; acetone / 6 h / 15 - 20 °C
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

4-{5-[bis(2-chloro-ethyl)amino]-1-methyl-2-benzimidazolyl}butyric acid hydrochloride

4-{5-[bis(2-chloro-ethyl)amino]-1-methyl-2-benzimidazolyl}butyric acid hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium acetate; acetic acid / water / 23 h / 0 - 25 °C
2: thionyl chloride / dichloromethane / 6 h / Reflux
3: lithium hydroxide / water; acetone / 6 h / 15 - 20 °C
4: hydrogenchloride / water / 65 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium acetate trihydrate / water; acetic acid / 23 h / 0 - 25 °C
1.2: 20 - 25 °C
2.1: thionyl chloride / dichloromethane / 6 h / 35 - 45 °C
3.1: lithium hydroxide monohydrate / water; acetone / 15 - 20 °C
4.1: hydrogenchloride / water / 65 °C
View Scheme
Multi-step reaction with 4 steps
1: calcium carbonate / acetonitrile / 80 - 90 °C
2: thionyl chloride / dichloromethane / 6 h / 35 - 45 °C
3: lithium hydroxide monohydrate / water; acetone / 15 - 20 °C
4: hydrogenchloride / water / 65 °C
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate; acetic acid / water / 23 h / 0 - 25 °C
2: thionyl chloride / dichloromethane / 6 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: calcium carbonate / acetonitrile / 80 - 90 °C
2: thionyl chloride / dichloromethane / 6 h / 35 - 45 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid / water / -5 - 0 °C
2: thionyl chloride / dichloromethane / 2 h / -5 - 20 °C
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

bendamustine hydrochloride
3543-75-7

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium carbonate; sodium iodide / 65 - 70 °C
2.1: thionyl chloride / dichloromethane / 0 °C / Reflux
2.2: 80 - 90 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale
2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
3: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5
2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
3: hydrogenchloride / water; acetone / 40 - 75 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
2.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
2.2: 75 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid / water / -5 - 0 °C
2: thionyl chloride / dichloromethane / 2 h / -5 - 20 °C
3: hydrogenchloride / water / 4 h / Reflux
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

bendamustine
16506-27-7

bendamustine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5
2: thionyl chloride / dichloromethane / 16 h / 5 - 20 °C
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

bendamustine hydrochloride

bendamustine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale
2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
View Scheme
Multi-step reaction with 2 steps
1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5
2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

2-bromoethanol
540-51-2

2-bromoethanol

A

C20H32N3O5(1+)*Br(1-)

C20H32N3O5(1+)*Br(1-)

B

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
3543-74-6

4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester

Conditions
ConditionsYield
With diammonium hydrogenphosphate In water at 65 - 70℃; pH=4.2 - 5.5;
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

lithium 4-[1-methyl-5-bis-(2-chloroethyl)-benzimidazolyl-2]butanoate

lithium 4-[1-methyl-5-bis-(2-chloroethyl)-benzimidazolyl-2]butanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium acetate trihydrate / water; acetic acid / 23 h / 0 - 25 °C
1.2: 20 - 25 °C
2.1: thionyl chloride / dichloromethane / 6 h / 35 - 45 °C
3.1: lithium hydroxide monohydrate / water; acetone / 15 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: calcium carbonate / acetonitrile / 80 - 90 °C
2: thionyl chloride / dichloromethane / 6 h / 35 - 45 °C
3: lithium hydroxide monohydrate / water; acetone / 15 - 20 °C
View Scheme
chloroacetic acid
79-11-8

chloroacetic acid

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester

4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid ethyl ester

Conditions
ConditionsYield
Stage #1: chloroacetic acid; ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate In tetrahydrofuran at 20℃; for 1.5h; Inert atmosphere;
Stage #2: With borane-THF In tetrahydrofuran at 55 - 58℃; for 1.83333h;
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl‐4,6‐d2)butanoate‐2,2,4,4‐d4

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl‐4,6‐d2)butanoate‐2,2,4,4‐d4

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen chloride; water-d2; water / 1.5 h / 180 °C / Microwave irradiation; Sealed tube
2: thionyl chloride / 4.5 h / 0 - 50 °C
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

ethyl 4‐(5‐(bis (2‐hydroxyethyl)amino)‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl‐4,6‐d2)butanoate‐2,2,4,4‐d4

ethyl 4‐(5‐(bis (2‐hydroxyethyl)amino)‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl‐4,6‐d2)butanoate‐2,2,4,4‐d4

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen chloride; water-d2; water / 1.5 h / 180 °C / Microwave irradiation; Sealed tube
2: thionyl chloride / 4.5 h / 0 - 50 °C
3: acetic acid / water-d2 / 19 h / 0 - 25 °C
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

C18H19(2)H6Cl2N3O2

C18H19(2)H6Cl2N3O2

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen chloride; water-d2; water / 1.5 h / 180 °C / Microwave irradiation; Sealed tube
2: thionyl chloride / 4.5 h / 0 - 50 °C
3: acetic acid / water-d2 / 19 h / 0 - 25 °C
4: thionyl chloride / dichloromethane / 10 h / 0 - 25 °C
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

4‐(5‐(bis(2‐chloroethyl)amino)‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl‐4,6‐d2)butanoic‐2,2,4,4‐d4 acid hydrochloride

4‐(5‐(bis(2‐chloroethyl)amino)‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl‐4,6‐d2)butanoic‐2,2,4,4‐d4 acid hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen chloride; water-d2; water / 1.5 h / 180 °C / Microwave irradiation; Sealed tube
2: thionyl chloride / 4.5 h / 0 - 50 °C
3: acetic acid / water-d2 / 19 h / 0 - 25 °C
4: thionyl chloride / dichloromethane / 10 h / 0 - 25 °C
5: hydrogen chloride; water / water-d2 / 2 h / Reflux
View Scheme
2-(2-Chloroethoxy)ethanol
628-89-7

2-(2-Chloroethoxy)ethanol

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

C18H27N3O4

C18H27N3O4

Conditions
ConditionsYield
With sodium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃;
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

C20H31N3O5

C20H31N3O5

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 °C
2: acetic acid / water / 24 h / 5 - 10 °C / Sealed tube
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 °C
2: sodium ethanolate / ethanol / 48 h / 0 - 10 °C / Sealed tube
View Scheme
Multi-step reaction with 2 steps
1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 85 °C
2: acetic acid / water / 24 h / 5 - 10 °C / Sealed tube
View Scheme
Multi-step reaction with 2 steps
1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 85 °C
2: sodium ethanolate / ethanol / 48 h / 0 - 10 °C / Sealed tube
View Scheme
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
3543-73-5

ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate

C18H25Cl2N3O3*ClH

C18H25Cl2N3O3*ClH

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 °C
2.1: acetic acid / water / 24 h / 5 - 10 °C / Sealed tube
3.1: thionyl chloride; chloroform / chloroform / 0 - 50 °C
3.2: 80 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 °C
2.1: sodium ethanolate / ethanol / 48 h / 0 - 10 °C / Sealed tube
3.1: thionyl chloride; chloroform / chloroform / 0 - 50 °C
3.2: 80 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 85 °C
2.1: acetic acid / water / 24 h / 5 - 10 °C / Sealed tube
3.1: thionyl chloride; chloroform / chloroform / 0 - 50 °C
3.2: 80 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 85 °C
2.1: sodium ethanolate / ethanol / 48 h / 0 - 10 °C / Sealed tube
3.1: thionyl chloride; chloroform / chloroform / 0 - 50 °C
3.2: 80 °C
View Scheme

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