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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/925.html Product Name 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
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inquiryBendamustine HCl[CAS:3543-75-7] Ethyl 4-(1-Methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate[CAS:3543-72-4] Ethyl 4-(1-Methyl-5-amino-1H-benzo[d]imidazol-2-yl)butanoate[CAS:3543-73-5] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an int
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inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryTIANFUCHEM--3543-73-5--1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China An
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Synonyms 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester;butanoic acid ethyl ester CAS: 354
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inquiryAppearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiry4‐(1‐methyl‐5‐nitro‐1H‐benzoimidazol‐2‐yl)butyric acid ethyl ester
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol; ethyl acetate at 20℃; for 16h; | 98.3% |
With 5% Pd/C-iron; hydrogen In ethanol under 3000.3 Torr; | 87.5% |
With 5%-palladium/activated carbon; hydrogen In methanol; acetic acid at 25℃; under 750.075 - 1500.15 Torr; for 15h; | 77.8% |
6-fluoro-3-nitroaniline
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / toluene / 4 h / 85 °C 1.2: 3 h / 75 °C 2.1: sulfuric acid / 10 h / Reflux 3.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr View Scheme | |
Multi-step reaction with 4 steps 1.1: toluene / 4 h / 70 - 85 °C 2.1: water / 3 h / 75 °C 2.2: 55 - 60 °C 3.1: sulfuric acid / 10 h / Reflux 4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / toluene / 4 h / 85 °C 1.2: 3 h / 75 °C 2.1: sulfuric acid / 10 h / Reflux 3.1: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr View Scheme | |
Multi-step reaction with 4 steps 1.1: toluene / 4 h / 70 - 85 °C 2.1: water / 3 h / 75 °C 2.2: 55 - 60 °C 3.1: sulfuric acid / 10 h / Reflux 4.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr View Scheme |
4-(1-methyl-5-nitro-1H-benzimidazol-2-yl)butanoic acid
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid / 10 h / Reflux 2: 5% Pd/C-iron; hydrogen / ethanol / 3000.3 Torr View Scheme |
5-(2-fluoro-5-nitroanilino)-5-oxopentanoic acid
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: water / 3 h / 75 °C 1.2: 55 - 60 °C 2.1: sulfuric acid / 10 h / Reflux 3.1: ferrous(II) sulfate heptahydrate; hydrogen; Iron(III) nitrate nonahydrate; 5% Pd/C / ethanol / 3000.3 Torr View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
With water; water-d2; hydrogen chloride at 180℃; for 1.5h; Microwave irradiation; Sealed tube; | 93.5% |
2,4-dinitrobenzoyl chloride
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
ethyl 4-(5-(2,4-dinitrobenzamido)-1-methyl-1H-benzimidazol-2-yl)butanoate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 83% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 25℃; for 24h; | 82.9% |
oxirane
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: oxirane; ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate With sodium acetate trihydrate In water; acetic acid at 0 - 25℃; for 23h; Stage #2: With potassium carbonate In dichloromethane at 20 - 25℃; | 78.53% |
With acetic acid In water at -5 - 0℃; | 78.5% |
Stage #1: ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate With acetic acid In water at 0 - 5℃; Stage #2: oxirane In water at 0 - 20℃; for 1.5h; |
oxirene
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
Conditions | Yield |
---|---|
With sodium acetate; acetic acid In water at 0 - 25℃; for 23h; Concentration; Temperature; Time; Reagent/catalyst; Solvent; | 78.53% |
2-(2-bromoethoxy)ethan-1-ol
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 85℃; | 66% |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
2-bromoethanol
4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
Conditions | Yield |
---|---|
With calcium carbonate In acetonitrile at 80 - 90℃; | 56.3% |
With potassium carbonate In water at 69 - 70℃; for 13.5h; pH=4.2 - 5.5; Large scale; | 343.5 g |
With diammonium phosphate; potassium iodide In water at 65 - 70℃; pH=4.2 - 5.5; Reagent/catalyst; pH-value; Temperature; | 17.2 g |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
2-chloro-ethanol
4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide at 20 - 70℃; | |
With sodium carbonate; sodium iodide at 65 - 70℃; | 10 g |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium acetate; acetic acid / water / 23 h / 0 - 25 °C 2: thionyl chloride / dichloromethane / 6 h / Reflux 3: lithium hydroxide / water; acetone / 6 h / 15 - 20 °C View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium acetate; acetic acid / water / 23 h / 0 - 25 °C 2: thionyl chloride / dichloromethane / 6 h / Reflux 3: lithium hydroxide / water; acetone / 6 h / 15 - 20 °C 4: hydrogenchloride / water / 65 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium acetate trihydrate / water; acetic acid / 23 h / 0 - 25 °C 1.2: 20 - 25 °C 2.1: thionyl chloride / dichloromethane / 6 h / 35 - 45 °C 3.1: lithium hydroxide monohydrate / water; acetone / 15 - 20 °C 4.1: hydrogenchloride / water / 65 °C View Scheme | |
Multi-step reaction with 4 steps 1: calcium carbonate / acetonitrile / 80 - 90 °C 2: thionyl chloride / dichloromethane / 6 h / 35 - 45 °C 3: lithium hydroxide monohydrate / water; acetone / 15 - 20 °C 4: hydrogenchloride / water / 65 °C View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium acetate; acetic acid / water / 23 h / 0 - 25 °C 2: thionyl chloride / dichloromethane / 6 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: calcium carbonate / acetonitrile / 80 - 90 °C 2: thionyl chloride / dichloromethane / 6 h / 35 - 45 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetic acid / water / -5 - 0 °C 2: thionyl chloride / dichloromethane / 2 h / -5 - 20 °C View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
bendamustine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium carbonate; sodium iodide / 65 - 70 °C 2.1: thionyl chloride / dichloromethane / 0 °C / Reflux 2.2: 80 - 90 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale 2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 3: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5 2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 3: hydrogenchloride / water; acetone / 40 - 75 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5 2.1: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C 2.2: 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetic acid / water / -5 - 0 °C 2: thionyl chloride / dichloromethane / 2 h / -5 - 20 °C 3: hydrogenchloride / water / 4 h / Reflux View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
bendamustine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium iodide; diammonium phosphate / water / 65 - 70 °C / pH 4.2 - 5.5 2: thionyl chloride / dichloromethane / 16 h / 5 - 20 °C View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / Large scale 2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C View Scheme | |
Multi-step reaction with 2 steps 1: diammonium hydrogenphosphate / water / 65 - 70 °C / pH 4.2 - 5.5 2: thionyl chloride / dichloromethane / 17 h / -1 - 22 °C View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
2-bromoethanol
B
4-{5-[bis-(2-hydroxyl-ethyl)-amino]-1-methyl-1H-benzoimidazol-2yl}-butyric acid ethyl ester
Conditions | Yield |
---|---|
With diammonium hydrogenphosphate In water at 65 - 70℃; pH=4.2 - 5.5; |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium acetate trihydrate / water; acetic acid / 23 h / 0 - 25 °C 1.2: 20 - 25 °C 2.1: thionyl chloride / dichloromethane / 6 h / 35 - 45 °C 3.1: lithium hydroxide monohydrate / water; acetone / 15 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: calcium carbonate / acetonitrile / 80 - 90 °C 2: thionyl chloride / dichloromethane / 6 h / 35 - 45 °C 3: lithium hydroxide monohydrate / water; acetone / 15 - 20 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: chloroacetic acid; ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate In tetrahydrofuran at 20℃; for 1.5h; Inert atmosphere; Stage #2: With borane-THF In tetrahydrofuran at 55 - 58℃; for 1.83333h; |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen chloride; water-d2; water / 1.5 h / 180 °C / Microwave irradiation; Sealed tube 2: thionyl chloride / 4.5 h / 0 - 50 °C View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen chloride; water-d2; water / 1.5 h / 180 °C / Microwave irradiation; Sealed tube 2: thionyl chloride / 4.5 h / 0 - 50 °C 3: acetic acid / water-d2 / 19 h / 0 - 25 °C View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogen chloride; water-d2; water / 1.5 h / 180 °C / Microwave irradiation; Sealed tube 2: thionyl chloride / 4.5 h / 0 - 50 °C 3: acetic acid / water-d2 / 19 h / 0 - 25 °C 4: thionyl chloride / dichloromethane / 10 h / 0 - 25 °C View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogen chloride; water-d2; water / 1.5 h / 180 °C / Microwave irradiation; Sealed tube 2: thionyl chloride / 4.5 h / 0 - 50 °C 3: acetic acid / water-d2 / 19 h / 0 - 25 °C 4: thionyl chloride / dichloromethane / 10 h / 0 - 25 °C 5: hydrogen chloride; water / water-d2 / 2 h / Reflux View Scheme |
2-(2-Chloroethoxy)ethanol
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
With sodium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 °C 2: acetic acid / water / 24 h / 5 - 10 °C / Sealed tube View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 °C 2: sodium ethanolate / ethanol / 48 h / 0 - 10 °C / Sealed tube View Scheme | |
Multi-step reaction with 2 steps 1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 85 °C 2: acetic acid / water / 24 h / 5 - 10 °C / Sealed tube View Scheme | |
Multi-step reaction with 2 steps 1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 85 °C 2: sodium ethanolate / ethanol / 48 h / 0 - 10 °C / Sealed tube View Scheme |
ethyl 4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)butanoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 °C 2.1: acetic acid / water / 24 h / 5 - 10 °C / Sealed tube 3.1: thionyl chloride; chloroform / chloroform / 0 - 50 °C 3.2: 80 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 °C 2.1: sodium ethanolate / ethanol / 48 h / 0 - 10 °C / Sealed tube 3.1: thionyl chloride; chloroform / chloroform / 0 - 50 °C 3.2: 80 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 85 °C 2.1: acetic acid / water / 24 h / 5 - 10 °C / Sealed tube 3.1: thionyl chloride; chloroform / chloroform / 0 - 50 °C 3.2: 80 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 85 °C 2.1: sodium ethanolate / ethanol / 48 h / 0 - 10 °C / Sealed tube 3.1: thionyl chloride; chloroform / chloroform / 0 - 50 °C 3.2: 80 °C View Scheme |
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