As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:85721-33-1
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inquiryItems Standard Result Appearance Almost white or pale yellow crystalline powder Pale yellow crystalline powder Ide
Cas:85721-33-1
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inquiryWe are very compeitive on Ciprofloxacin HCl.Our mfr is GMP certified for this item with CEP document. Product Name: Ciprofloxacin CAS: 85721-33-1 MF: C17H18FN3O3.H
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inquiry1.High quality : the purity is 99% min . through multiple producing procedures. 2.Competitive price : low price because of our skilled production technolpgy ,save the production cost at most , and give big profit room to our customers
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inquiryFactory supplies Ciprofloxacin,Ciprofloxacin Base CAS 85721-33-1 TAIHO Unique Advantages: 1.We're factory 2.Free samples available 3.Commodity inspection can be done 4.ISO9001,Kosher certifications 5.10 years experiences Appearance:powder Storag
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:85721-33-1
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:85721-33-1
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
Cas:85721-33-1
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inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c
Cas:85721-33-1
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:85721-33-1
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white or off-white powder Storage:Store in sealed containers
Cas:85721-33-1
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:85721-33-1
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:85721-33-1
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inquiry85721-33-1 Appearance:pale yellow powder Storage:0-5°C Package:as client requirement Application:Fluorinated quinolone antibacterial Transportation:Express, Air ,Sea Port:Any port of China
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:85721-33-1
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inquiryCiprofloxacin CAS:85721-33-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:85721-33-1
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:85721-33-1
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. 3) OEM/ODM Available; 4) Reasonable & Compet
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inquiryAppearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture.The third generation quinolone antibi
Cas:85721-33-1
Min.Order:100 Metric Ton
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Type:Lab/Research institutions
inquiryQ1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo
Cas:85721-33-1
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:85721-33-1
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inquirySpecification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:85721-33-1
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:85721-33-1
Min.Order:20 Gram
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Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:85721-33-1
Min.Order:10 Kilogram
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Type:Trading Company
inquiryCiprofloxacin CAS 85721-33-1 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control sy
Cas:85721-33-1
Min.Order:1 Kilogram
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Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Ciprofloxacin CAS 85721-33-1 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2
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inquiry7-[4-tert-butoxycarbonyl-piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
ciprofloxacin
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 2h; | 98.7% |
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium hydroxide at 70℃; for 5h; Reagent/catalyst; Temperature; | 96.2% |
ciprofloxacin hydrochloride
ciprofloxacin
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water | 96% |
With sodium hydrogencarbonate In water | 95% |
With ammonium hydroxide In water at 30 - 55℃; for 4.41667h; pH=6.8; Temperature; Reagent/catalyst; pH-value; | 82.52% |
piperazine
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
ciprofloxacin
Conditions | Yield |
---|---|
With nano iron oxide on ZrO2 coated sulfonic acid In water for 0.366667h; Reflux; | 94% |
at 150℃; Microwave irradiation; | 90% |
With aluminum tri-bromide In ethanol at 75℃; for 4h; Reagent/catalyst; Solvent; Temperature; | 89.7% |
piperazine
ciprofloxacin
Conditions | Yield |
---|---|
With aluminum (III) chloride In i-Amyl alcohol at 140℃; for 8h; Reagent/catalyst; Temperature; | 91.2% |
piperazine
1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
ciprofloxacin
Conditions | Yield |
---|---|
In pyridine for 18h; Heating; | 89% |
In water | |
In dimethyl sulfoxide Heating; | 960 mg |
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
ciprofloxacin
Conditions | Yield |
---|---|
88% |
piperazine
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
A
ciprofloxacin
Conditions | Yield |
---|---|
In water for 15h; Heating; | A 86% B n/a |
In water at 150℃; for 5h; | A 65% B 10% |
In dimethylsulfoxide-d6 at 120 - 130℃; | A 87 % Spectr. B 13 % Spectr. |
ciprofloxacin
Conditions | Yield |
---|---|
With adsorption onto charcoal; trifluoroacetic acid 2.) dichloromethane; | 57% |
With adsorption onto charcoal; trifluoroacetic acid In dichloromethane Product distribution; solid/solution phase synthesis to eliminate impurities; | |
With water; pyrographite; trifluoroacetic acid In dichloromethane at 20℃; for 0.25h; Hydrolysis; |
piperazine
ethyl 2,4,5-trifluorobenzoylacetate
N,N-dimethyl-formamide dimethyl acetal
Cyclopropylamine
ciprofloxacin
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
piperazine
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid boron diacetate
ciprofloxacin
Conditions | Yield |
---|---|
With sodium hydroxide 1.) DMSO, 110 deg C, 2 h; 2.) reflux, 1 h; Yield given; |
ciprofloxacin
Conditions | Yield |
---|---|
With sodium hydroxide for 1h; Heating; |
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 71 percent / BF3*Et2O / diethyl ether; CH2Cl2 / 5 h / Heating 2: 96 percent / triethylamine / dimethylsulfoxide / 3 h / 60 °C 3: aq. NaOH / 1 h / Heating View Scheme |
C13H8BClF3NO3
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 96 percent / triethylamine / dimethylsulfoxide / 3 h / 60 °C 2: aq. NaOH / 1 h / Heating View Scheme |
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid methyl ester
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Alkaline hydrolysis 2: butan-1-ol / 5 h / 135 °C View Scheme | |
Multi-step reaction with 2 steps 1: 92 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating 2: 79 percent / pyridine / 8 h / Heating View Scheme |
methyl 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylate
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: K2CO3 / dimethylformamide / 5 h / 130 °C 2: Alkaline hydrolysis 3: butan-1-ol / 5 h / 135 °C View Scheme |
ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylate
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. HCl / Heating 2: 89 percent / pyridine / 18 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: dimethyl sulfoxide / Heating 2: sodium hydroxide / dimethyl sulfoxide / 90 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride; water; acetic acid / 2.5 h / Reflux 2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 140 °C 3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C View Scheme |
3-Cyclopropylamino-2-(2,4,5-trifluorbenzoyl)acrylsaeure-ethylester
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: t-BuOK / 2-methyl-propan-2-ol 2: aq. HCl / Heating 3: 89 percent / pyridine / 18 h / Heating View Scheme |
ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: acetic anhydride / 2 h / Heating 2: 92 percent / ethanol / 1 h / Ambient temperature 3: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 4: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 5: 79 percent / pyridine / 8 h / Heating View Scheme |
3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-ethylester
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 2: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 3: 79 percent / pyridine / 8 h / Heating View Scheme |
ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylate
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 2: 79 percent / pyridine / 8 h / Heating View Scheme |
2,4-dichloro-5-fluorobenzoyl chloride
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 62 percent / pyridine / dioxane / 1.) 2 h, room temperature, 2.) 1 h, 70 - 80 deg C. 2: 85 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 3: 92 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating 4: 79 percent / pyridine / 8 h / Heating View Scheme | |
Multi-step reaction with 7 steps 1: Mg/ethanol, CCl4 / ethanol; toluene / 1.) 0 to -5 deg C, 2.) 12 h, room temperature 2: p-toluenesulfonic acid / H2O / 5 h / Heating 3: acetic anhydride / 2 h / Heating 4: 92 percent / ethanol / 1 h / Ambient temperature 5: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 6: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 7: 79 percent / pyridine / 8 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: tributyl-amine / 1 h / 70 °C 1.2: 15 °C / 1520.1 Torr 2.1: sodium hydroxide / 5,5-dimethyl-1,3-cyclohexadiene / 125 - 130 °C 2.2: 8 h / 85 °C View Scheme |
3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-methylester
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 85 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 2: 92 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating 3: 79 percent / pyridine / 8 h / Heating View Scheme |
diethyl 2,4-dichloro-5-fluoro-benzoyl-malonate
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: p-toluenesulfonic acid / H2O / 5 h / Heating 2: acetic anhydride / 2 h / Heating 3: 92 percent / ethanol / 1 h / Ambient temperature 4: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 5: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 6: 79 percent / pyridine / 8 h / Heating View Scheme |
3-(Cyclopropylamino)acrylsaeure-methylester
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 62 percent / pyridine / dioxane / 1.) 2 h, room temperature, 2.) 1 h, 70 - 80 deg C. 2: 85 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 3: 92 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating 4: 79 percent / pyridine / 8 h / Heating View Scheme |
2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester
ciprofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 92 percent / ethanol / 1 h / Ambient temperature 2: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 3: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 4: 79 percent / pyridine / 8 h / Heating View Scheme |
C17H18FN3O3*H3N
ciprofloxacin
Conditions | Yield |
---|---|
Purification / work up; HPLC column; |
7-[4-(ethoxycarbonyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
ciprofloxacin
Conditions | Yield |
---|---|
Stage #1: 7-[4-(ethoxycarbonyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid With potassium hydroxide; water for 3 - 6h; Heating / reflux; Stage #2: With hydrogenchloride In water at 20℃; for 0.5h; pH=7.7 - 7.9; Product distribution / selectivity; |
ciprofloxacin
Conditions | Yield |
---|---|
Purification / work up; HPLC column; |
di-tert-butyl dicarbonate
ciprofloxacin
7-[4-tert-butoxycarbonyl-piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran at 20℃; for 16h; Inert atmosphere; | 100% |
Stage #1: ciprofloxacin With sodium hydroxide In 1,4-dioxane; water Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 20℃; for 48h; | 99% |
With trimethylamine In tetrahydrofuran at 0 - 20℃; for 8.16667h; | 97.3% |
ciprofloxacin
propionyl chloride
Conditions | Yield |
---|---|
With TEA In tetrahydrofuran at 20℃; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 1.5h; | 75% |
Stage #1: ciprofloxacin With triethylamine In dichloromethane at 0℃; for 0.25h; Stage #2: propionyl chloride In dichloromethane at 0 - 20℃; |
formaldehyd
{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1,3,4-oxadiazole-2-thiol
ciprofloxacin
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 100℃; for 0.0833333h; Temperature; Time; Mannich Aminomethylation; Microwave irradiation; Sealed tube; | 100% |
Conditions | Yield |
---|---|
In methanol; water at 20℃; for 3h; | 100% |
Conditions | Yield |
---|---|
In methanol; water at 20℃; for 2h; | 100% |
ciprofloxacin
toluenesulfonic acid 3-azidopropyl ester
7-(4-(3-azidopropyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; sodium iodide In acetonitrile Inert atmosphere; Reflux; | 100% |
formaldehyd
ciprofloxacin
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 100℃; for 0.0833333h; Temperature; Time; Mannich Aminomethylation; Microwave irradiation; Sealed tube; | 99% |
Conditions | Yield |
---|---|
In methanol; water at 20℃; for 2h; | 99% |
ciprofloxacin
ciprofloxacin hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water Heating; | 98% |
With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 1h; | 95% |
With hydrogenchloride In methanol; water at 45 - 50℃; for 2h; Product distribution / selectivity; |
ciprofloxacin
ethyl bromoacetate
Conditions | Yield |
---|---|
Stage #1: ciprofloxacin With sodium In ethanol for 0.0666667h; Sealed tube; Microwave irradiation; Stage #2: ethyl bromoacetate In ethanol for 0.166667h; Microwave irradiation; | 98% |
With potassium iodide; triethylamine In N-methyl-acetamide; water |
pent-4-enoyl chloride
ciprofloxacin
Conditions | Yield |
---|---|
With sodium acetate In dichloromethane at 20℃; for 0.166667h; | 98% |
formaldehyd
ciprofloxacin
Conditions | Yield |
---|---|
With indium(III) chloride In water; N,N-dimethyl-formamide at 20℃; for 4.5h; Reagent/catalyst; Mannich Aminomethylation; | 98% |
Conditions | Yield |
---|---|
In methanol; water at 140℃; Concentration; Temperature; | 98% |
tert-butyldicarbonate
ciprofloxacin
7-[4-tert-butoxycarbonyl-piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
Conditions | Yield |
---|---|
In methanol; chloroform | 97% |
In methanol; chloroform | 97% |
succinic acid anhydride
ciprofloxacin
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 95℃; for 12h; Inert atmosphere; | 97% |
In dimethyl sulfoxide at 95℃; for 24h; | 59% |
With sodium hydroxide In 1,4-dioxane; water |
ciprofloxacin
Conditions | Yield |
---|---|
With water In dimethyl sulfoxide for 24h; | 97% |
formaldehyd
ciprofloxacin
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 50℃; for 0.0833333h; Temperature; Microwave irradiation; | 97% |
formaldehyd
ciprofloxacin
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 100℃; for 0.0833333h; Temperature; Time; Mannich Aminomethylation; Microwave irradiation; Sealed tube; | 97% |
formaldehyd
ciprofloxacin
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In water; N,N-dimethyl-formamide at 20℃; for 4h; Reagent/catalyst; Mannich Aminomethylation; | 97% |
formaldehyd
ciprofloxacin
Conditions | Yield |
---|---|
In neat (no solvent) for 0.25h; Solvent; Mannich Aminomethylation; Microwave irradiation; Green chemistry; | 97% |
formaldehyd
ciprofloxacin
Conditions | Yield |
---|---|
With indium(III) chloride In N,N-dimethyl-formamide at 20℃; for 24h; Mannich Aminomethylation; | 97% |
6-(tert-butoxycarbonylamino)hexanoic acid
ciprofloxacin
7-(4-(6-((tert-butoxycarbonyl)amino)hexanoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 4h; | 96% |
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine at 20℃; |
Conditions | Yield |
---|---|
In acetone at 20℃; | 96% |
Conditions | Yield |
---|---|
With hydrogenchloride at 50℃; for 0.333333h; Microwave irradiation; Sealed tube; | 96% |
ciprofloxacin
triethylamine
Conditions | Yield |
---|---|
In ethanol; water Michael Addition; Reflux; | 96% |
ciprofloxacin
chloroacetyl chloride
Conditions | Yield |
---|---|
With pyridine In tetrahydrofuran at 40℃; for 12h; | 95% |
Stage #1: ciprofloxacin With sodium hydrogencarbonate In dichloromethane for 0.333333h; Cooling with ice; Stage #2: chloroacetyl chloride In dichloromethane at -5℃; | 85% |
With triethylamine In dichloromethane at 0 - 20℃; for 1.4h; | 73% |
formaldehyd
ciprofloxacin
Conditions | Yield |
---|---|
With hydrogenchloride In neat (no solvent) for 0.0833333h; Solvent; Mannich Aminomethylation; Microwave irradiation; Sealed tube; Green chemistry; | 95% |
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