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Henan Sigma Biotechnology Co., Ltd.

1. We integrate research and development, production, and sales. A 1800 square meter research and development center,The company has conducted over 50 research and development and technical service projects annually, applied for more than 10 patents,

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Trading Company

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. usually have it in stock 3. can supply at large quantity 4. audit accepted. related documents are available to offer and audited by many clients, such as lupin, msn, dr reddy etc 5. chromatographic p

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-Carbamoymethyl-5-methylhexanoic acid Manufacturer/High quality/Best price/In stock

Cas:181289-15-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (+)-3-(Carbamoylmethyl)-5-Methylhexanoic Acid supplier in China

Cas:181289-15-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

3-(Carbamoylmethyl)-5-methyl-hexanoic acid 181289-15-6 M f:C9H17NO3 3-(Carbamoylmethyl)-5-methyl-hexanoic acid 3-(Carbamoylmethyl)-5-methyl-hexanoic acid Molecular formula:C9H17NO3 CAS No181289-15-6 Appe

CAS:181289-15-6 3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:1 Kilogram

Negotiable

Type:Other

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 3-Carbamoymethyl-5-methylhexanoic acid CAS No.

3-(2-Amino-2-oxoethyl)-5-methylhexanoic

Cas:181289-15-6

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (+)-3-(Carbamoylmethyl)-5-Methylhexanoic Acid

Cas:181289-15-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 3-Carbamoymethyl-5-methylhexanoic acid 181289-15-6 ISO Producer

Cas:181289-15-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-(Carbamoylmethyl)-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--181289-15-6--3-Carbamoymethyl-5-methylhexanoic acid factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established

TIANFUCHEM--181289-15-6--3-Carbamoymethyl-5-methylhexanoic acid factory price

Cas:181289-15-6

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-Carbamoymethyl-5-methylhexanoic acid ;181289-15-6

Cas:181289-15-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 181289-15-6 with best quality

Cas:181289-15-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 3-Carbamoymethyl-5-methylhexanoic acid Synonyms: 3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid CAS: 181289-15-6 MF: C9H17NO3 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application:Organ

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystalline granules or powder. Storage:Store in seale

3-Carbamoymethyl-5-methylhexanoic acid cas no 181289-15-6

Cas:181289-15-6

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Carbamoymethyl-5-methylhexanoic acid 181289-15-6

Cas:181289-15-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

3-Carbamoymethyl-5-methylhexanoic acid/ LIDE PHARMA- Factory supply / Best price

Cas:181289-15-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:1 Kilogram

FOB Price: $45.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Amisulpride CAS: 71675-85-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

3-Carbamoymethyl-5-methylhexanoic acid CAS:181289-15-6

Cas:181289-15-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

3-Carbamoymethyl-5-methylhexanoic acid CAS NO.181289-15-6

Cas:181289-15-6

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-(2-Amino-2-Oxoethyl)-5-Methylhexanoic Acid

Cas:181289-15-6

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:off-white crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common product

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(+)-3-(Carbamoylmethyl)-5-methylhexanoic acid

Cas:181289-15-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
With ammonia In water at -10 - 40℃; for 1.5h;100%
With ammonium hydroxide at 10℃; for 2h; Temperature;95%
Stage #1: 3-isobutylglutaric anhydride With ammonia In tert-butyl methyl ether; water at 0 - 20℃;
Stage #2: With hydrogenchloride In tert-butyl methyl ether; water pH=2;
80.4%
5-methyl-3-carboxymethylhexanoic acid
75143-89-4

5-methyl-3-carboxymethylhexanoic acid

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
With urea In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; for 3h; Temperature; Solvent;93.5%
With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate In acetonitrile at 5 - 20℃; for 0.5h; Solvent;72.4%
With hydrogenchloride; ammonium hydroxide; acetic anhydride In tert-butyl methyl ether; water; ethyl acetate
3-isobutylglutarimide

3-isobutylglutarimide

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
With potassium carbonate In 5,5-dimethyl-1,3-cyclohexadiene; water at 30℃; for 1h; Reagent/catalyst; Temperature;86.6%
Stage #1: 3-isobutylglutarimide With water; sodium hydroxide at 60℃; for 1h;
Stage #2: With hydrogenchloride; water
31 g
With sodium hydroxide at 50 - 90℃;
C10H15NO4

C10H15NO4

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
With water; sodium hydroxide at 65℃; for 0.583333h; Temperature;79%
methyl 3-(2-amino-2-oxoethyl)-5-methylhexanoate

methyl 3-(2-amino-2-oxoethyl)-5-methylhexanoate

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
With water; lithium hydroxide In tetrahydrofuran; methanol at 20℃; for 3h;76%
(1'SR,3 SR)-1-(1'-napthyl)ethyl-3-(carboxylomethyl)-5-methylhexanoate
1385049-46-6

(1'SR,3 SR)-1-(1'-napthyl)ethyl-3-(carboxylomethyl)-5-methylhexanoate

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
Stage #1: (1'SR,3 SR)-1-(1'-napthyl)ethyl-3-(carboxylomethyl)-5-methylhexanoate With chloroformic acid ethyl ester; triethylamine In acetone at -20℃; Inert atmosphere;
Stage #2: With ammonia In water; acetone at -20℃; for 2h;
Stage #3: With sodium hydroxide In water at 0℃;
58%
tert-butyl methyl ether
1634-04-4

tert-butyl methyl ether

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
With ammonium hydroxide In water
(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid
181289-34-9

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
Stage #1: (S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid With toluene-4-sulfonic acid In toluene Reflux;
Stage #2: With sodium hydroxide In water; toluene at 25 - 65℃;
Stage #3: With hydrogenchloride In water at 10 - 15℃; for 1.5h; Product distribution / selectivity;
isovaleraldehyde
590-86-3

isovaleraldehyde

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: di-n-propylamine; ethyl 2-cyanoacetate / cyclohexane / 2 h / 25 - 30 °C / Reflux
1.2: 5.17 h / 25 - 50 °C
1.3: 48 h / Reflux
2.1: urea / 12 h / 130 - 135 °C
2.2: 60 - 90 °C
View Scheme
Multi-step reaction with 5 steps
1.1: piperidine; pyridine; acetic acid / hexane / 48 h / Reflux; Inert atmosphere
2.1: di-n-propylamine / 16 h / 15 - 55 °C
3.1: hydrogen bromide / water / 72 h / 100 °C
4.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
5.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
5.2: pH 2
View Scheme
Multi-step reaction with 6 steps
1.1: piperidine; pyridine; acetic acid / hexane / 48 h / Reflux; Inert atmosphere
2.1: di-n-propylamine / 16 h / 15 - 55 °C
3.1: hydrogen bromide / water / 72 h / 100 °C
4.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
5.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere
6.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
6.2: 2 h / -20 °C
6.3: 0 °C
View Scheme
Multi-step reaction with 4 steps
1: tetramethyl ammoniumhydroxide; trimethyldodecylammonium chloride / ethanol / 6 h / 25 °C
2: water; hydrogenchloride / 30 h / 140 °C / pH 1 - 2
3: acetic anhydride / 2 h / 120 °C
4: ammonium hydroxide / 2 h / 10 °C
View Scheme
Multi-step reaction with 4 steps
1.1: piperidine / hexane / 100 °C / Dean-Stark
2.1: piperidine / 2 h / 55 °C
2.2: 72 h / 100 - 120 °C
3.1: 5 h / 160 °C
4.1: sodium hydroxide; water / 0.58 h / 65 °C
View Scheme
diethyl 2-(3-methylbutylidene)malonate
51615-30-6

diethyl 2-(3-methylbutylidene)malonate

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: di-n-propylamine / 16 h / 15 - 55 °C
2.1: hydrogen bromide / water / 72 h / 100 °C
3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
4.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
4.2: pH 2
View Scheme
Multi-step reaction with 5 steps
1.1: di-n-propylamine / 16 h / 15 - 55 °C
2.1: hydrogen bromide / water / 72 h / 100 °C
3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
4.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere
5.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
5.2: 2 h / -20 °C
5.3: 0 °C
View Scheme
2-isobutyl-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester
102710-09-8

2-isobutyl-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen bromide / water / 72 h / 100 °C
2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
3.2: pH 2
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogen bromide / water / 72 h / 100 °C
2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
3.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere
4.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
4.2: 2 h / -20 °C
4.3: 0 °C
View Scheme
2,4-dicyano-3-isobutylglutaramide

2,4-dicyano-3-isobutylglutaramide

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; hydrogenchloride / 30 h / 140 °C / pH 1 - 2
2: acetic anhydride / 2 h / 120 °C
3: ammonium hydroxide / 2 h / 10 °C
View Scheme
2‑cyano‑5‑methylhex‑2‑enoic acid methyl ester
868-52-0

2‑cyano‑5‑methylhex‑2‑enoic acid methyl ester

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: piperidine / 2 h / 55 °C
1.2: 72 h / 100 - 120 °C
2.1: 5 h / 160 °C
3.1: sodium hydroxide; water / 0.58 h / 65 °C
View Scheme
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
With D-phenylglycine butyl ester In isopropyl alcohol Heating;90.39%
With (R)-1-phenyl-ethyl-amine In methanol; chloroform at 25 - 40℃; for 3.16h; Solvent; Temperature;41%
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With (R)-1-phenyl-ethyl-amine In ethanol; chloroform for 0.75h; Reflux;
Stage #2: With hydrogenchloride In ethanol; chloroform; water for 0.75h; Cooling;
40%
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(R,S)-3-iso-butyl-4-aminobutyric acid
128013-69-4, 130912-52-6, 148553-50-8, 148553-51-9

(R,S)-3-iso-butyl-4-aminobutyric acid

Conditions
ConditionsYield
With bromine; sodium hydroxide In water at 0 - 85℃; for 3h; Temperature; Large scale;89%
With bromine; sodium hydroxide In water at 5 - 60℃; for 2h;81%
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With sodium hydroxide; water; bromine at 5 - 60℃; for 0.5h; Hofmann Rearrangement;
Stage #2: With sulfuric acid In 2-methyl-propan-1-ol; water
Stage #3: With tributyl-amine In 2-methyl-propan-1-ol at 2 - 10℃; for 1.5 - 2h; Product distribution / selectivity;
80.4%
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

A

(R)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine
185815-61-6

(R)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine

B

(S)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine

(S)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine

Conditions
ConditionsYield
In chloroform at 55℃; for 1.5h;A 79.2%
B n/a
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Quinine
130-95-0

Quinine

R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid quinine salt

R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid quinine salt

Conditions
ConditionsYield
With acetone In water at 80℃;67.9%
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(R)-1-(1-Naphthyl)ethylamine
3886-70-2

(R)-1-(1-Naphthyl)ethylamine

(R)-(+)-1-(1-naphthyl)ethylamine salt of (S)-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid
1001296-58-7

(R)-(+)-1-(1-naphthyl)ethylamine salt of (S)-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid

Conditions
ConditionsYield
In methanol; ethyl acetate at 25 - 68℃; Heating / reflux;
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(2S)-2-phenylglycinol
20989-17-7

(2S)-2-phenylglycinol

(S)-(+)-phenylglycinol salt of (S)-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid
1001296-60-1

(S)-(+)-phenylglycinol salt of (S)-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid

Conditions
ConditionsYield
In methanol; ethyl acetate at 25 - 68℃; Heating / reflux;
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(R)-Phenylglycinol
56613-80-0

(R)-Phenylglycinol

(R)-(-)-phenylglycinol salt of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid
1001296-65-6

(R)-(-)-phenylglycinol salt of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid

Conditions
ConditionsYield
In 1,4-dioxane at 25 - 90℃;
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With sodium hydroxide; water; bromine at 10 - 60℃; for 0.5 - 5.75h; Hofmann Rearrangement;
Stage #2: With sulfuric acid In 2-methyl-propan-1-ol; water at 20℃; for 0.5 - 24h;
Stage #3: With tributyl-amine In 2-methyl-propan-1-ol at 2℃; for 1.5 - 2h; Product distribution / selectivity;
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With sodium hydroxide; water; bromine at 15 - 60℃; for 0.5h; Hofmann Rearrangement;
Stage #2: With sulfuric acid In 2-methyl-propan-1-ol; water
Stage #3: With tributyl-amine In 2-methyl-propan-1-ol; water at 2℃; for 2h; Product distribution / selectivity;
Multi-step reaction with 2 steps
1.1: chloroform / 0.5 h / 50 - 55 °C
2.1: sodium hydroxide; bromine / water / 1.25 h / -5 - 55 °C
2.2: 0 - 5 °C / pH 6.7
View Scheme
Multi-step reaction with 3 steps
1.1: chloroform / 0.92 h / 52.5 °C
2.1: hydrogenchloride / water / 22.5 - 42.5 °C
3.1: sodium hydroxide; sodium hypochlorite / water / 3.04 h / 7.5 - 42.5 °C
3.2: 0.29 h / 27.5 °C
View Scheme
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

C12H22N2O4

C12H22N2O4

Conditions
ConditionsYield
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid; chloroformic acid ethyl ester With triethylamine In tetrahydrofuran at -10℃; for 0.5h;
Stage #2: With sodium azide In tetrahydrofuran; water at -10℃; for 2h;
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

(R)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine
185815-61-6

(R)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine

Conditions
ConditionsYield
In ethanol; chloroform at 30 - 55℃; for 1h; Product distribution / selectivity;
In chloroform; isopropyl alcohol at 30 - 60℃; for 3.75h; Product distribution / selectivity;
In acetone at 30 - 55℃; for 2.5h; Product distribution / selectivity;
In ethanol; chloroform at 55℃;
In chloroform at 50 - 55℃; for 0.5h;
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

A

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

B

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid
181289-34-9

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid

Conditions
ConditionsYield
With (R)-1-phenyl-ethyl-amine Resolution of racemate;
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid
181289-34-9

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid

Conditions
ConditionsYield
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With (S)-1-phenyl-ethylamine In ethanol; chloroform for 0.75h; Reflux;
Stage #2: With hydrogenchloride In ethanol; chloroform; water for 0.75h; Cooling;
16 g
Multi-step reaction with 2 steps
1: chloroform / 1.5 h / 55 °C
2: hydrogenchloride / water / pH 1 - 2
View Scheme
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(S)-Mandelic acid
17199-29-0

(S)-Mandelic acid

(S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (S)-mandelate
185815-62-7

(S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (S)-mandelate

Conditions
ConditionsYield
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With bromine; sodium hydroxide In water at 5 - 50℃; Hofmann Reaction;
Stage #2: (S)-Mandelic acid With hydrogenchloride In water at 20 - 22℃; pH=4.5 - 5.5; Heating;
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

1-phenylpropylamine
2941-20-0

1-phenylpropylamine

R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt
1385049-51-3

R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt

Conditions
ConditionsYield
In ethanol; chloroform at 60 - 63℃; for 0.75h;
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

(3R)-3-(carbamoylmethyl)-5-methylhexanoic acid phenylethylamine

(3R)-3-(carbamoylmethyl)-5-methylhexanoic acid phenylethylamine

Conditions
ConditionsYield
In chloroform at 52.5℃; for 0.916667h;367 g
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(-)-menthol
2216-51-5

(-)-menthol

A

C19H35NO3

C19H35NO3

B

C19H35NO3

C19H35NO3

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Overall yield = 87.8 %;A 1.436 g
B 1.416 g
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