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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. usually have it in stock 3. can supply at large quantity 4. audit accepted. related documents are available to offer and audited by many clients, such as lupin, msn, dr reddy etc 5. chromatographic p

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid Manufacturer/High quality/Best price/In stock

Cas:181289-33-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (R)-(-)-3-Carbamoymethyl-5-Methylhexanoic Acid supplier in China

Cas:181289-33-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Assay: 99% up; Stable supply with over 50Mt annually; Appearance:White or off-white powder Storage:room temprature Package:1kg/bag, 25kg/drum Application:Intermediate of Pregabalin Port:Beijing/Shanghai/Shenzhen/Hangzhou

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid, Intermediate of Pregabalin

Cas:181289-33-8

Min.Order:1 Kilogram

FOB Price: $875.0 / 955.0

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% -----------------------------------------------------------------------------------------------------------

High purity (R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid 181289-33-8

Cas:181289-33-8

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (3R)-3-(2-amino-2-oxoethyl)-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Hexanoic acid,3-(2-amino-2-oxoethyl)-5-methyl-, (3R)- 181289-33-8 ISO Producer

Cas:181289-33-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality (R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA. Product quality, process, price and service (R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid CAS 181289-33-8 Factory IN STOCK (R)-(-)-3-(2-Amino-2-oxoethyl)-5-methylhexanoic aci

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:5 Metric Ton

FOB Price: $1100.0 / 1500.0

Type:Trading Company

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1179.html Product Name (R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid CAS No.

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:1 Gram

FOB Price: $11.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--181289-33-8--(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had esta

TIANFUCHEM--181289-33-8--(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid factory price

Cas:181289-33-8

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid CAS 181289-33-8

Cas:181289-33-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 181289-33-8 with competitive price

Cas:181289-33-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:10 Kilogram

FOB Price: $80.0 / 100.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: (R)-(-)-3-(Carbamoymethyl)-5-methylhexanoic acid CAS:181289-33-8 MF: C9H17NO3 Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application: organic synthesis Transportation:By sea or by air Port:

(R)-(-)-3-(Carbamoymethyl)-5-methylhexanoic acid CAS:181289-33-8

Cas:181289-33-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid CAS NO 181289-33-8

Cas:181289-33-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Hexanoic acid,3-(2-amino-2-oxoethyl)-5-methyl-, (3R)- 181289-33-8

Cas:181289-33-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Hexanoic acid,3-(2-amino-2-oxoethyl)-5-methyl-, (3R)-/ LIDE PHARMA- Factory supply / Best price

Cas:181289-33-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: (R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid CAS: 181289-33-8 MF: C9H17NO3 MW: 187.24 EINECS: 605-923-8 Mol File: 181289-33-8.mol (R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid Structure (R)-(-)-3-Carbamoymethyl-5-

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid CAS:181289-33-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid CAS:181289-33-8

Cas:181289-33-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Hexanoic acid,3-(2-amino-2-oxoethyl)-5-methyl-, (3R)-

Cas:181289-33-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(R)-(-)-3-Carbamoymethyl-5-Methylhexanoic Acid

Cas:181289-33-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

(R)-(-)-3-(Carbamoymethyl)-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(R)-(-)-3-(Carbamoymethyl)-5-methylhexanoic acid

Cas:181289-33-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1‐phenylethan‐1‐amine 3‐(carbamoylmethyl)‐5‐methylhexanoate

1‐phenylethan‐1‐amine 3‐(carbamoylmethyl)‐5‐methylhexanoate

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Stage #1: 1‐phenylethan‐1‐amine 3‐(carbamoylmethyl)‐5‐methylhexanoate With hydrogenchloride In water at 10 - 30℃; for 2h; pH=0.5 - 2;
Stage #2: With sulfuric acid In water at 6 - 40℃; for 3h; pH=1.5; Temperature; Reagent/catalyst; Solvent;
100%
3-isobutylglutarimide

3-isobutylglutarimide

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
With water In tetrahydrofuran at 45℃; for 15h; Reagent/catalyst; Solvent; Temperature;96.1%
(3S)-3-(2-(allyloxy)-2-oxoethyl)-5-methylhexanoic acid
1403953-91-2

(3S)-3-(2-(allyloxy)-2-oxoethyl)-5-methylhexanoic acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Stage #1: (3S)-3-(2-(allyloxy)-2-oxoethyl)-5-methylhexanoic acid With magnesium nitride In methanol at 20 - 80℃; for 16h;
Stage #2: With hydrogenchloride In methanol; water pH=3 - 4;
93%
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
With D-phenylglycine butyl ester In isopropyl alcohol Heating;90.39%
With (R)-1-phenyl-ethyl-amine In methanol; chloroform at 25 - 40℃; for 3.16h; Solvent; Temperature;41%
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With (R)-1-phenyl-ethyl-amine In ethanol; chloroform for 0.75h; Reflux;
Stage #2: With hydrogenchloride In ethanol; chloroform; water for 0.75h; Cooling;
40%
(-)-3-cyclohexylsulfanylcarbonylmethyl-5-methyl-hexanoic acid
1237492-10-2

(-)-3-cyclohexylsulfanylcarbonylmethyl-5-methyl-hexanoic acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
With ammonia In water at 40℃;88%
(3S)-3-(2-ethoxy-2-oxoethyl)-5-methylhexanoic acid
1082077-07-3

(3S)-3-(2-ethoxy-2-oxoethyl)-5-methylhexanoic acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Stage #1: (3S)-3-(2-ethoxy-2-oxoethyl)-5-methylhexanoic acid With ammonium iodide; sodium amide In tetrahydrofuran at 20℃; for 4h; Cooling with ice; Green chemistry;
Stage #2: With hydrogenchloride In water pH=4 - 5; Reagent/catalyst; Solvent; Green chemistry;
86.7%
With ammonia; calcium chloride In methanol at 55 - 60℃; under 3000.3 - 3375.34 Torr; Autoclave;
With ammonia; calcium chloride In methanol at 25 - 70℃; under 375.038 - 2250.23 Torr; Autoclave;
(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid
181289-25-8

(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Stage #1: (3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid With ammonia In water at 20 - 80℃; under 760.051 - 1520.1 Torr; for 6 - 92h;
Stage #2: With hydrogenchloride In water pH=1 - 3; Product distribution / selectivity;
60%
Stage #1: (3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid With ammonia; ammonium chloride In water at 20 - 40℃; for 42.5h;
Stage #2: With hydrogenchloride In water pH=4; Product distribution / selectivity;
Stage #1: (3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid With ammonia In water; toluene at 20℃; for 88h;
Stage #2: With sulfuric acid In water pH=3; Product distribution / selectivity;
With ammonium hydroxide at 25 - 90℃; for 75h; Reagent/catalyst; Temperature;75 g
(3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid
930585-94-7

(3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Stage #1: (3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid With ammonia; water; lithium In tetrahydrofuran at -40℃; for 6 - 10h;
Stage #2: With hydrogenchloride In water pH=1.5 - 1.7; Product distribution / selectivity;
59.37%
Stage #1: (3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid With ammonia; water; sodium In tetrahydrofuran at -40℃; for 6 - 10h;
Stage #2: With hydrogenchloride In water pH=1.5 - 1.7; Product distribution / selectivity;
39.37%
With sulfuric acid In tetrahydrofuran at 25 - 30℃; Product distribution / selectivity;39%
With palladium 10% on activated carbon; hydrogen In methanol at 30℃; under 7500.75 Torr; for 12h; Autoclave; Industrial scale;
R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt
1385049-51-3

R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Stage #1: R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt With ammonia In water at 80℃; for 5h;
Stage #2: With hydrogenchloride In water at 0℃; pH=1;
53%
(R)-methyl 3-(carbamoylmethyl)-5-methylhexanoate

(R)-methyl 3-(carbamoylmethyl)-5-methylhexanoate

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Stage #1: (R)-methyl 3-(carbamoylmethyl)-5-methylhexanoate With hydrogenchloride In water at 20 - 25℃; for 1 - 10h;
Stage #2: With sodium hydroxide In water pH=3; Product distribution / selectivity;
Stage #1: (R)-methyl 3-(carbamoylmethyl)-5-methylhexanoate With hydrogenchloride; water at 20 - 25℃;
Stage #2: With sodium hydroxide In water pH=3;
methanol
67-56-1

methanol

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Stage #1: methanol; 3-isobutylglutaric anhydride With quinidine at -50℃; for 17h;
Stage #2: With ammonia In water at 20 - 40℃; for 72h;
Stage #3: With hydrogenchloride In water pH=3; Product distribution / selectivity;
(R)-(-)-phenylglycinol salt of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid
1001296-65-6

(R)-(-)-phenylglycinol salt of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 60 - 62℃;n/a
(R)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine
185815-61-6

(R)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 31℃; pH=1.7;
With hydrogenchloride In water at 20 - 25℃; for 1.47h;
With hydrogenchloride In water pH=1 - 2;1.21 g
(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

A

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

B

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid
181289-34-9

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid

Conditions
ConditionsYield
With (R)-1-phenyl-ethyl-amine Resolution of racemate;
(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid
181289-25-8

(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid

A

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

B

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid
181289-34-9

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid

Conditions
ConditionsYield
Stage #1: (3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid With ammonia In water at 20℃; for 92h;
Stage #2: With hydrogenchloride In water pH=3;
5-methyl-3-carboxymethylhexanoic acid
75143-89-4

5-methyl-3-carboxymethylhexanoic acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: urea / 12 h / 130 - 135 °C
1.2: 60 - 90 °C
2.1: chloroform / 0.5 h / 50 - 55 °C
3.1: hydrogenchloride / water / 1.47 h / 20 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
2.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
2.2: pH 2
3.1: acetone / water / 80 °C
4.1: ammonia / water / 5 h / 80 °C
4.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 4 steps
1.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
2.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
2.2: pH 2
3.1: chloroform; ethanol / 0.75 h / 60 - 63 °C
4.1: ammonia / water / 5 h / 80 °C
4.2: 0 °C / pH 1
View Scheme
(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid
181289-34-9

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / toluene / Reflux
1.2: 25 - 65 °C
1.3: 1.5 h / 10 - 15 °C
2.1: chloroform / 0.5 h / 50 - 55 °C
3.1: hydrogenchloride / water / 1.47 h / 20 - 25 °C
View Scheme
isovaleraldehyde
590-86-3

isovaleraldehyde

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: di-n-propylamine; ethyl 2-cyanoacetate / cyclohexane / 2 h / 25 - 30 °C / Reflux
1.2: 5.17 h / 25 - 50 °C
1.3: 48 h / Reflux
2.1: urea / 12 h / 130 - 135 °C
2.2: 60 - 90 °C
3.1: chloroform / 0.5 h / 50 - 55 °C
4.1: hydrogenchloride / water / 1.47 h / 20 - 25 °C
View Scheme
Multi-step reaction with 7 steps
1.1: piperidine; pyridine; acetic acid / hexane / 48 h / Reflux; Inert atmosphere
2.1: di-n-propylamine / 16 h / 15 - 55 °C
3.1: hydrogen bromide / water / 72 h / 100 °C
4.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
5.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
5.2: pH 2
6.1: acetone / water / 80 °C
7.1: ammonia / water / 5 h / 80 °C
7.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 7 steps
1.1: piperidine; pyridine; acetic acid / hexane / 48 h / Reflux; Inert atmosphere
2.1: di-n-propylamine / 16 h / 15 - 55 °C
3.1: hydrogen bromide / water / 72 h / 100 °C
4.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
5.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
5.2: pH 2
6.1: chloroform; ethanol / 0.75 h / 60 - 63 °C
7.1: ammonia / water / 5 h / 80 °C
7.2: 0 °C / pH 1
View Scheme
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
1.2: pH 2
2.1: acetone / water / 80 °C
3.1: ammonia / water / 5 h / 80 °C
3.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 3 steps
1.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
1.2: pH 2
2.1: chloroform; ethanol / 0.75 h / 60 - 63 °C
3.1: ammonia / water / 5 h / 80 °C
3.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 4 steps
1.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere
2.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
2.2: 2 h / -20 °C
2.3: 0 °C
3.1: acetone / water / 80 °C
4.1: ammonia / water / 5 h / 80 °C
4.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 4 steps
1.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere
2.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
2.2: 2 h / -20 °C
2.3: 0 °C
3.1: chloroform; ethanol / 0.75 h / 60 - 63 °C
4.1: ammonia / water / 5 h / 80 °C
4.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 2 steps
1: dmap / toluene / -20 - -10 °C / Industrial scale
2: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 30 °C / 7500.75 Torr / Autoclave; Industrial scale
View Scheme
diethyl 2-(3-methylbutylidene)malonate
51615-30-6

diethyl 2-(3-methylbutylidene)malonate

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: di-n-propylamine / 16 h / 15 - 55 °C
2.1: hydrogen bromide / water / 72 h / 100 °C
3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
4.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
4.2: pH 2
5.1: acetone / water / 80 °C
6.1: ammonia / water / 5 h / 80 °C
6.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 6 steps
1.1: di-n-propylamine / 16 h / 15 - 55 °C
2.1: hydrogen bromide / water / 72 h / 100 °C
3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
4.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
4.2: pH 2
5.1: chloroform; ethanol / 0.75 h / 60 - 63 °C
6.1: ammonia / water / 5 h / 80 °C
6.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 7 steps
1.1: di-n-propylamine / 16 h / 15 - 55 °C
2.1: hydrogen bromide / water / 72 h / 100 °C
3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
4.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere
5.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
5.2: 2 h / -20 °C
5.3: 0 °C
6.1: chloroform; ethanol / 0.75 h / 60 - 63 °C
7.1: ammonia / water / 5 h / 80 °C
7.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 7 steps
1.1: di-n-propylamine / 16 h / 15 - 55 °C
2.1: hydrogen bromide / water / 72 h / 100 °C
3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
4.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere
5.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
5.2: 2 h / -20 °C
5.3: 0 °C
6.1: acetone / water / 80 °C
7.1: ammonia / water / 5 h / 80 °C
7.2: 0 °C / pH 1
View Scheme
2-isobutyl-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester
102710-09-8

2-isobutyl-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogen bromide / water / 72 h / 100 °C
2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
3.2: pH 2
4.1: acetone / water / 80 °C
5.1: ammonia / water / 5 h / 80 °C
5.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogen bromide / water / 72 h / 100 °C
2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C
3.2: pH 2
4.1: chloroform; ethanol / 0.75 h / 60 - 63 °C
5.1: ammonia / water / 5 h / 80 °C
5.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 6 steps
1.1: hydrogen bromide / water / 72 h / 100 °C
2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
3.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere
4.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
4.2: 2 h / -20 °C
4.3: 0 °C
5.1: chloroform; ethanol / 0.75 h / 60 - 63 °C
6.1: ammonia / water / 5 h / 80 °C
6.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 6 steps
1.1: hydrogen bromide / water / 72 h / 100 °C
2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
3.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere
4.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
4.2: 2 h / -20 °C
4.3: 0 °C
5.1: acetone / water / 80 °C
6.1: ammonia / water / 5 h / 80 °C
6.2: 0 °C / pH 1
View Scheme
(1'SR,3 SR)-1-(1'-napthyl)ethyl-3-(carboxylomethyl)-5-methylhexanoate
1385049-46-6

(1'SR,3 SR)-1-(1'-napthyl)ethyl-3-(carboxylomethyl)-5-methylhexanoate

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
1.2: 2 h / -20 °C
1.3: 0 °C
2.1: acetone / water / 80 °C
3.1: ammonia / water / 5 h / 80 °C
3.2: 0 °C / pH 1
View Scheme
Multi-step reaction with 3 steps
1.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere
1.2: 2 h / -20 °C
1.3: 0 °C
2.1: chloroform; ethanol / 0.75 h / 60 - 63 °C
3.1: ammonia / water / 5 h / 80 °C
3.2: 0 °C / pH 1
View Scheme
R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid quinine salt

R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid quinine salt

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Stage #1: R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid quinine salt With ammonia In water at 80℃; for 5h;
Stage #2: With hydrogenchloride In water at 0℃; pH=1;
1,5-diallyl 3-isobutylpentanedioate
1403953-90-1

1,5-diallyl 3-isobutylpentanedioate

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: immobilized lipase B from Candida antartica; sodium hydroxide / aq. phosphate buffer / 15.6 h / 25 °C / pH 7 / Enzymatic reaction
2.1: magnesium nitride / methanol / 16 h / 20 - 80 °C
2.2: pH 3 - 4
View Scheme
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