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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Methyl 3-amino-4-methylthiophene-2-carboxylate Manufacturer/High quality/Best price/In stock

Cas:85006-31-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Methyl-3-Amino-4-Methylthiophene-2-Carboxylate supplier in China

Cas:85006-31-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Methyl 3-amino-4-methylthiophene-2-carboxylate CAS No.:85006-31-1 Name: Methyl 3-amino-4-methylthiophene-2-carboxylate Synonyms: Methyl 3-amino-4-methyl-2-thenoate; 3-Amino-4-methylthiophene-2-ca

High purity Methyl 3-amino-4-methylthiophene-2-carboxylate CAS No.:85006-31-1

Cas:85006-31-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Methyl 3-amino-4-methylthiophene-2-carboxylate, 98%

Cas:85006-31-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Methyl 3-amino-4-methyl-2-thenoate

Cas:85006-31-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 85006-31-1 Metoclopramide methyl Manufacturer

Cas:85006-31-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Amino-4-methyl-2-thiophenecarboxylic acid methyl ester

Cas:85006-31-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

tianfu-chem_ethyl 3-amino-4-methylthiophene-2-carboxylate 85006-31-1

Cas:85006-31-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Superiority As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, to

cas 85006-31-1 3-Amino-4-Methyl-2-Thiophene Carboxylic Acid Methyl Ester

Cas:85006-31-1

Min.Order:1 Kilogram

FOB Price: $1350.0 / 2200.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 85006-31-1 with competitive price

Cas:85006-31-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

Methyl 3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:1 Kilogram

FOB Price: $65.0 / 75.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name Methyl 3-amino-4-methylthiophene-2-carboxylate Synonyms 3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER CAS No. 85006-31-1 EINECS No. 28

Methyl-3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Light yellow crystal Storage:R.T Package:25kg/drum Application:Pharma intermediates Transportation:Express/Sea/Air Port:Any port in China

Methyl 3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

Methyl 3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Thiophenecarboxylicacid, 3-amino-4-methyl-, methyl ester 85006-31-1

Cas:85006-31-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Methyl 3-amino-4-methylthiophene-2-carboxylate CAS:85006-31-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

Methyl 3-amino-4-methylthiophene-2-carboxylate CAS:85006-31-1

Cas:85006-31-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Thiophenecarboxylicacid, 3-amino-4-methyl-, methyl ester

Cas:85006-31-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:85006-31-1

Cas:85006-31-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:slight yellow to off-white crystallin Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Commo

Methyl-3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Methyl 3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

METHYL-3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLATE

Cas:85006-31-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Methyl 3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Methyl 3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

Methyl 3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Methyl 3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Methyl-3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:white to light yellow crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermedia

Methyl 3-amino-4-methylthiophene-2-carboxylate-

Cas:85006-31-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in

Enke Methyl 3-amino-4-methylthiophene-2-carboxylate

Cas:85006-31-1

Min.Order:1 Kilogram

FOB Price: $300.0 / 400.0

Type:Lab/Research institutions

inquiry

Synthetic route

4-methyl-3-oxotetrahydro-2-thiophencarboxylic acid methyl ester
2689-70-5

4-methyl-3-oxotetrahydro-2-thiophencarboxylic acid methyl ester

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: 4-methyl-3-oxotetrahydro-2-thiophencarboxylic acid methyl ester With iron(III) chloride; 1,3,5-trichloro-2,4,6-triazine; hydroxylamine hydrochloride In N,N-dimethyl-formamide at 70 - 90℃; for 4h;
Stage #2: With ammonium hydroxide for 0.5h; Reagent/catalyst; Temperature;
96.5%
With MH2OH*HCl In acetonitrile for 5h; Heating;64%
With hydroxylamine hydrochloride In acetonitrile
3-amino-2-carbomethoxy-4-methyl-4,5-dihydrothiophene
125089-02-3

3-amino-2-carbomethoxy-4-methyl-4,5-dihydrothiophene

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

Conditions
ConditionsYield
With dihydrogen peroxide In ethyl acetate; isopropyl alcohol
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

tert‐butyl N‐(4‐methylthiophen‐3‐yl)carbamate
1097629-78-1

tert‐butyl N‐(4‐methylthiophen‐3‐yl)carbamate

Conditions
ConditionsYield
Stage #1: 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester With potassium hydroxide In water at 20 - 80℃; for 0.5h;
Stage #2: With hydrogenchloride In water at 50 - 60℃; for 0.25h;
Stage #3: di-tert-butyl dicarbonate With potassium hydroxide In hexane; water; acetone at -10 - 20℃;
100%
Stage #1: 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester With water; potassium hydroxide at 20 - 80℃; Inert atmosphere;
Stage #2: With hydrogenchloride In water at 50 - 60℃;
Stage #3: di-tert-butyl dicarbonate With potassium hydroxide In water at 5 - 20℃; Inert atmosphere;
81%
N-(benzyloxycarbonyl)glycyl chloride
15050-24-5

N-(benzyloxycarbonyl)glycyl chloride

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene
135429-76-4

3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene

Conditions
ConditionsYield
In N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile Ambient temperature;99.3%
formic acid
64-18-6

formic acid

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-formamido-4-methylthiophene-2-carboxylate
443762-03-6

methyl 3-formamido-4-methylthiophene-2-carboxylate

Conditions
ConditionsYield
Stage #1: formic acid With acetic anhydride at 0℃;
Stage #2: 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester at 0 - 20℃; for 4h;
97%
With (1-methyl-3-(3-sulfopropyl)-1H-imidazol-3-ium)3[PW12O403-] In neat (no solvent) at 70℃; for 1h; Green chemistry;88%
Stage #1: formic acid; 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester In acetic anhydride at 0 - 20℃; for 18h;
Stage #2: for 0.5h;
81%
trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 4-methyl-3-[(trifluoroacetyl)amino]thiophene-2-carboxylate
1000409-43-7

methyl 4-methyl-3-[(trifluoroacetyl)amino]thiophene-2-carboxylate

Conditions
ConditionsYield
With pyridine In acetonitrile at 0 - 20℃;96%
With pyridine In acetonitrile at 0 - 20℃; for 2h;96%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h;95%
3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

2,4-dimethyl-3-amino-thiophene
87685-15-2

2,4-dimethyl-3-amino-thiophene

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 80℃; for 3h; Inert atmosphere;96%
With lithium aluminium tetrahydride In tetrahydrofuran for 3.5h; Cooling with ice; Reflux;60.6%
Stage #1: 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester With lithium aluminium tetrahydride In tetrahydrofuran for 3.5h; Cooling with ice; Reflux;
Stage #2: With sodium hydroxide In tetrahydrofuran; water at 0℃; for 1h;
60.6%
With sodium bis(2-methoxyethoxy)aluminum dihydride In potassium hydroxide; toluene
With sodium bis(2-methoxyethoxy)aluminum dihydride In potassium hydroxide; toluene
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

3-Ethoxycarbonylamino-4-methyl-thiophene-2-carboxylic acid methyl ester
118252-13-4

3-Ethoxycarbonylamino-4-methyl-thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
In toluene for 3h; Heating;94%
2,6-difluorobenzoylchloride
18063-02-0

2,6-difluorobenzoylchloride

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

3-(2,6-difluoro-benzylamino)-4-methyl-thiophene-2-carboxylic acid methyl ester

3-(2,6-difluoro-benzylamino)-4-methyl-thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With pyridine at 20℃; for 168h;94%
urea
57-13-6

urea

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

7-methylthieno<3,2-d>pyrimidine-2,4-dione
35265-81-7

7-methylthieno<3,2-d>pyrimidine-2,4-dione

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 2.5h; Heating / reflux;93.7%
for 1.5h; Heating;90%
In N,N-dimethyl-formamide at 200℃; for 1.5h;77%
at 160 - 200℃;61%
3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

7-methylthieno<3,2-d>pyrimidine-2,4-dione
35265-81-7

7-methylthieno<3,2-d>pyrimidine-2,4-dione

Conditions
ConditionsYield
With urea In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; N,N-dimethyl-formamide93.7%
With potassium cyanate; sodium hydroxide; acetic acid In water84%
Multi-step reaction with 2 steps
1: H2O / 12 h / Ambient temperature
2: 5percent aq. NaOH / 2 h
View Scheme
Multi-step reaction with 3 steps
1: dichloromethane / 0.37 h / -78 - 20 °C
2: hydrogenchloride; water / 2 h / Heating / reflux
3: methanol; sodium hydroxide; water / 2 h / Heating / reflux
View Scheme
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-4-methyl-5-(3-trifluoromethylphenyl)-thiophene-2-carboxylate
1246226-63-0

methyl 3-amino-4-methyl-5-(3-trifluoromethylphenyl)-thiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;92%
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;92%
cis,trans-2,5-dimethoxytetrahydrofuran
696-59-3

cis,trans-2,5-dimethoxytetrahydrofuran

4-chlorpyridine hydrochloride
7379-35-3

4-chlorpyridine hydrochloride

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 4-methyl-3-(pyrrol-1-yl)thiophene-2-carboxylate
179751-31-6

methyl 4-methyl-3-(pyrrol-1-yl)thiophene-2-carboxylate

Conditions
ConditionsYield
In 1,4-dioxane; water91%
3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

7-methyl-3,4-dihydrothieno[3,2-d]pyrimidin-4-one
175137-13-0

7-methyl-3,4-dihydrothieno[3,2-d]pyrimidin-4-one

Conditions
ConditionsYield
at 200℃; for 24h;91%
at 200℃; for 24h;91%
at 20℃;60%
o-cyanobromobenzene
2042-37-7

o-cyanobromobenzene

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-5-(2-cyanophenyl)-4-methylthiophene-2-carboxylate
1246226-66-3

methyl 3-amino-5-(2-cyanophenyl)-4-methylthiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;90%
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;90%
3-cyanobromobenzene
6952-59-6

3-cyanobromobenzene

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-5-(3-cyanophenyl)-4-methylthiophene-2-carboxylate
1393718-85-8

methyl 3-amino-5-(3-cyanophenyl)-4-methylthiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;90%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 5-(4-acetylphenyl)-3-amino-4-methylthiophene-2-carboxylate
1393718-78-9

methyl 5-(4-acetylphenyl)-3-amino-4-methylthiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;90%
4-bromopyridine hydrochloride
19524-06-2

4-bromopyridine hydrochloride

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-4-methyl-5-pyridin-4-ylthiophene-2-carboxylate
1246226-68-5

methyl 3-amino-4-methyl-5-pyridin-4-ylthiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;89%
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;89%
1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-5-(4-fluorophenyl)-4-methyl-thiophene-2-carboxylate
691394-01-1

methyl 3-amino-5-(4-fluorophenyl)-4-methyl-thiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;89%
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;89%
o-trifluoromethylphenyl bromide
392-83-6

o-trifluoromethylphenyl bromide

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-4-methyl-5-(2-trifluoromethylphenyl)-thiophene-2-carboxylate
1393718-90-5

methyl 3-amino-4-methyl-5-(2-trifluoromethylphenyl)-thiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;88%
2-bromobenzoic acid methyl ester
610-94-6

2-bromobenzoic acid methyl ester

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-5-(2-methoxycarbonylphenyl)-4-methylthiophene-2-carboxylate
1246226-65-2

methyl 3-amino-5-(2-methoxycarbonylphenyl)-4-methylthiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;87%
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;87%
4-bromobenzenecarbonitrile
623-00-7

4-bromobenzenecarbonitrile

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-5-(4-cyanophenyl)-4-methylthiophene-2-carboxylate
1246226-62-9

methyl 3-amino-5-(4-cyanophenyl)-4-methylthiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;87%
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;87%
4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-5-(4-formylphenyl)-4-methylthiophene-2-carboxylate
1246226-60-7

methyl 3-amino-5-(4-formylphenyl)-4-methylthiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;87%
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;87%
4'-Bromopropiophenone
10342-83-3

4'-Bromopropiophenone

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-4-methyl-5-(4-propionylphenyl)-thiophene-2-carboxylate
1246226-61-8

methyl 3-amino-4-methyl-5-(4-propionylphenyl)-thiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;86%
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;86%
Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

3-(ethoxyoxalylamino)-4-methylthiophene-2-carboxylic acid methyl ester

3-(ethoxyoxalylamino)-4-methylthiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 0.25h;84%
bromochlorobenzene
106-39-8

bromochlorobenzene

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-5-(4-chlorophenyl)-4-methylthiophene-2-carboxylate
691394-00-0

methyl 3-amino-5-(4-chlorophenyl)-4-methylthiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;84%
1-bromo-3-chlorobenzene
108-37-2

1-bromo-3-chlorobenzene

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

3-amino-5-(3-chlorophenyl)-4-methyl-thiophene-2-carboxylic acid methyl ester
1293119-61-5

3-amino-5-(3-chlorophenyl)-4-methyl-thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;84%
3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

(3-amino-4-methylthiophen-2-yl)methanol

(3-amino-4-methylthiophen-2-yl)methanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 4h; Cooling with ice;83.9%
para-nitrophenyl bromide
586-78-7

para-nitrophenyl bromide

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-4-methyl-5-(4-nitrophenyl)-thiophene-2-carboxylate
725234-25-3

methyl 3-amino-4-methyl-5-(4-nitrophenyl)-thiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;83%
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;83%
m-bromobenzoic aldehyde
3132-99-8

m-bromobenzoic aldehyde

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-5-(3-formylphenyl)-4-methylthiophene-2-carboxylate
1393718-83-6

methyl 3-amino-5-(3-formylphenyl)-4-methylthiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;83%
p-trifluoromethylphenyl bromide
402-43-7

p-trifluoromethylphenyl bromide

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester
85006-31-1

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

methyl 3-amino-4-methyl-5-(4-trifluoromethylphenyl)-thiophene-2-carboxylate
1246226-56-1

methyl 3-amino-4-methyl-5-(4-trifluoromethylphenyl)-thiophene-2-carboxylate

Conditions
ConditionsYield
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;82%
With PdCl(C3H5)(dppb); potassium acetate In N,N-dimethyl acetamide at 120℃; for 20h; Inert atmosphere;82%
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