Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:2042-37-7
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:2042-37-7
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:2042-37-7
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
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Cas:2042-37-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryHigh purity CAS 2042-37-7 2-Bromobenzonitrile in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediates (Fluore
Cas:2042-37-7
Min.Order:1 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:2042-37-7
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:2042-37-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:2042-37-7
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:2042-37-7
Min.Order:1 Kilogram
FOB Price: $25.0 / 28.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:2042-37-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical inte
Cas:2042-37-7
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:2042-37-7
Min.Order:1 Kilogram
FOB Price: $234.0 / 255.0
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:2042-37-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:2042-37-7
Min.Order:20 Metric Ton
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:2042-37-7
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
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Cas:2042-37-7
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:2042-37-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry2-Bromobenzonitrile Basic information Product Name: 2-Bromobenzonitrile Synonyms: 2-bromo-benzonitril;Benzonitrile, o-bromo-;o-bromo-benzonitril;2-of broMoxynil;2-BroMobenzonitrile, 97+%;2-Bromobenzonitrile,99%;2-Bromobenzonitrile ,98%;O BroMo
Cas:2042-37-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:2042-37-7
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryProduct name:2-Bromobenzonitrile CAS No.:2042-37-7 Molecule Formula:C7H4BrN Molecule Weight:182.02 Purity: 98.5% Package: 25kg/drum Description:White or light yellow crystals powder Manufacture Standards:Enterprise Standard
Cas:2042-37-7
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:2042-37-7
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:2042-37-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:2042-37-7
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiry2-bromobenzaldehyde oxime
o-cyanobromobenzene
Conditions | Yield |
---|---|
With phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester; triethylamine In acetonitrile at 20℃; for 0.583333h; | 98% |
With oxalyl dichloride; Tropone; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50℃; for 0.25h; Schlenk technique; Inert atmosphere; | 98% |
With oxalyl dichloride; triethylamine In dimethyl sulfoxide; acetonitrile at 20℃; for 1h; Swern Oxidation; | 93% |
Conditions | Yield |
---|---|
Stage #1: 2-methylphenyl bromide With hydrogen bromide; dihydrogen peroxide In tetrachloromethane; water at 20℃; for 1h; Irradiation; Stage #2: With ammonia; iodine In tetrachloromethane; water; acetonitrile at 20 - 60℃; for 24h; | 97% |
With tert.-butylnitrite; N-hydroxyphthalimide; palladium diacetate In acetonitrile at 70℃; for 24h; Inert atmosphere; Sealed tube; | 80% |
Stage #1: 2-methylphenyl bromide With sodium azide; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; zinc trifluoromethanesulfonate In acetonitrile at 25℃; Irradiation; Stage #2: With trifluorormethanesulfonic acid In acetonitrile for 1h; | 51% |
o-cyanobromobenzene
Conditions | Yield |
---|---|
With formic acid; tributyl-amine; 1,1′-(10-(4-acetylphenyl)-10H-phenothiazine-3,7-diyl)bis(ethan-1-one) In acetonitrile at 23℃; for 24h; UV-irradiation; chemoselective reaction; | 97% |
Conditions | Yield |
---|---|
With oxalyl dichloride; triethylamine; Triphenylphosphine oxide In acetonitrile at 20℃; for 0.166667h; | 95% |
With oxalyl dichloride; triethylamine In dimethyl sulfoxide; acetonitrile at 20℃; for 0.666667h; Swern Oxidation; | 95% |
With C36H38Cl6N6Pd3S2 In water; acetonitrile at 80℃; for 6h; Reagent/catalyst; | 78% |
ortho-bromophenylacetic acid
o-cyanobromobenzene
Conditions | Yield |
---|---|
With oxygen; copper(II) trifluoroacetate; urea In dimethyl sulfoxide at 110℃; for 26h; Green chemistry; | 95% |
Conditions | Yield |
---|---|
With ammonium acetate; phenyltrimethylammonium tribromide In acetonitrile at 20℃; for 15h; | 94% |
With sodium azide; trifluorormethanesulfonic acid In acetonitrile at 20℃; for 0.0333333h; Schmidt reaction; | 93% |
With ammonium iodide In dimethyl sulfoxide at 20℃; for 4h; Electrolysis; | 91% |
o-bromobenzyl alcohol
o-cyanobromobenzene
Conditions | Yield |
---|---|
With ammonium hydroxide; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; N-Phenylglycine; sodium hydroxide In methanol at 100℃; for 18h; Cooling with ice; | 90% |
With ammonia; oxygen In tert-Amyl alcohol; water at 130℃; under 3750.38 Torr; for 24h; | 90% |
Stage #1: o-bromobenzyl alcohol With sodium azide; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; zinc trifluoromethanesulfonate In acetonitrile at 25℃; Irradiation; Stage #2: With trifluorormethanesulfonic acid In acetonitrile for 1h; | 73% |
Multi-step reaction with 3 steps 1: potassium carbonate; fluorosulfonyl fluoride; dimethyl sulfoxide / 12 h / 20 °C 2: hydroxylamine hydrochloride; potassium carbonate / 20 °C 3: potassium carbonate; fluorosulfonyl fluoride / 12 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: anthranilic acid nitrile With Bromotrichloromethane; sodium nitrite In dichloromethane; water at 23℃; for 0.0833333h; Stage #2: With acetic acid In dichloromethane; water at 23℃; for 1h; | 89% |
With tetrabutylammomium bromide; 10-camphorsulfonic acid; sodium nitrite In acetonitrile at 20℃; for 24h; Reagent/catalyst; Time; Solvent; | 78% |
With tert.-butylnitrite; tetrabutylammomium bromide; toluene-4-sulfonic acid; copper(ll) bromide In acetonitrile at 20℃; for 1h; | 75% |
With tert.-butylnitrite; tetrabutylammomium bromide; toluene-4-sulfonic acid; copper(ll) bromide | 68% |
2-(2-bromo-phenyl)[1,3,4]oxadiazole
o-cyanobromobenzene
Conditions | Yield |
---|---|
With sodium t-butanolate In N,N-dimethyl-formamide at 20℃; for 4h; | 88% |
Conditions | Yield |
---|---|
With mesoporous silica SBA-15 supported Cu2O nanoparticles In N,N-dimethyl-formamide at 120℃; for 8h; Green chemistry; | 88% |
With 3% Au/CeO2; sodium carbonate In dimethyl sulfoxide; isopropyl alcohol at 65℃; for 12h; Irradiation; | 83% |
Conditions | Yield |
---|---|
With N-Bromosuccinimide; palladium diacetate; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 70℃; for 12h; Sealed tube; | 87% |
Conditions | Yield |
---|---|
With C68H64Cl2N6P2Ru2(4+)*2F6P(1-)*2Cl(1-); caesium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere; Green chemistry; | 85.4% |
With potassium hydroxide; dipotassium peroxodisulfate; ruthenium trichloride In water for 1.5h; | 83% |
With isoquinoline; oxygen; copper; ammonium bromide In toluene at 100℃; under 760.051 Torr; for 24h; Green chemistry; | 64.9 %Chromat. |
With ammonia; oxygen; silica gel; 11-pyridino[3,2-h]quinoxalino[2,3-f]quinolin-11-ylpyridino[3,2-h]quinoxalino[2,3-f]quinoline In tert-Amyl alcohol; N,N-dimethyl-formamide at 110 - 800℃; under 1500.15 Torr; for 16h; Sonication; Inert atmosphere; Calcination; | 73.27 %Chromat. |
2-bromobenzaldehyde oxime
1,3-diphenyl-2-propynone
A
3-hydroxy-1,3-diphenyl-2-propen-1-one
B
o-cyanobromobenzene
Conditions | Yield |
---|---|
With triphenylphosphine In dichloromethane at 25℃; for 3h; Inert atmosphere; Schlenk technique; Sealed tube; | A 88 %Spectr. B 85% |
2-cyano-benzenediazonium tetrafluoroborate
o-cyanobromobenzene
Conditions | Yield |
---|---|
With N-Bromosuccinimide; tetrabutylammonium perchlorate In methanol; N,N-dimethyl-formamide at 20℃; for 3h; Sandmeyer Reaction; Electrochemical reaction; | 84% |
2-<(trifluoromethanesulfonyl)oxy>benzonitrile
o-cyanobromobenzene
Conditions | Yield |
---|---|
With [Cp*Ru(CH3CN)3]OTf; lithium bromide at 100℃; for 12h; Inert atmosphere; | 83% |
Conditions | Yield |
---|---|
With cis-[Os(VIII)O4(OH)2](2-); [Fe(CN)6](3-); acetonitrile at 20℃; for 1.5h; | 82% |
Conditions | Yield |
---|---|
Stage #1: 1-Bromo-2-iodobenzene With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran at 0 - 23℃; for 3h; | 82% |
Conditions | Yield |
---|---|
With bromine fluoride In ethanol; chloroform at -40℃; for 0.25h; | A 81% B 10% |
With bromine trifluoride; bromine at 0 - 10℃; | A 45% B 12% |
Conditions | Yield |
---|---|
With formic acid; sodium nitrite In acetonitrile at 70℃; for 4h; Schlenk technique; | 78% |
With formic acid; 5,10,15,20‐tetrakis‐(4‐sulfonatophenyl)‐porphyrin‐iron(III) chloride; sodium nitrite In acetonitrile at 70℃; for 4.5h; | 78.49% |
With [bis(acetoxy)iodo]benzene; ammonium bicarbonate In methanol; water at 36℃; for 12h; Sealed tube; | 65% |
2-bromo-N-(isopropyl)benzamide
o-cyanobromobenzene
Conditions | Yield |
---|---|
With 2-fluoropyridine; trifluoromethylsulfonic anhydride In dichloromethane at 0 - 30℃; for 12h; chemoselective reaction; | 77% |
Conditions | Yield |
---|---|
With [Ru(η6-C6Me6)Cl2(tris(dimethylamino)phosphine)]; hydroxylamine hydrochloride; sodium hydrogencarbonate In water at 100℃; for 7h; Inert atmosphere; Sealed tube; Green chemistry; | A n/a B 76% |
Conditions | Yield |
---|---|
With aluminum oxide; aminosulfonic acid; urea for 0.216667h; Irradiation; | 75% |
Multi-step reaction with 3 steps 1: thionyl chloride 2: aqueous ammonia 3: thionyl chloride View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium carbonate; 18-crown-6 ether / tetrahydrofuran / 21 h / Inert atmosphere; Reflux 2.1: sodium diisobutyl-tert-butoxyaluminium hydride / tetrahydrofuran / 4 h / -40 - 0 °C / Inert atmosphere 2.2: 2 h / 0 - 20 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
With oxygen; copper diacetate; ammonium carbonate; tetra-(n-butyl)ammonium iodide In dimethyl sulfoxide at 120℃; for 5h; Schlenk technique; | 70% |
Conditions | Yield |
---|---|
With iodine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide at 65℃; for 1.5h; | A 68% B 6 %Chromat. |
Conditions | Yield |
---|---|
With ammonium hydroxide; oxygen In tert-Amyl alcohol at 110℃; under 1500.15 Torr; for 16h; | A 64.1% B 28.1% |
Conditions | Yield |
---|---|
With sodium carbonate In water; N,N-dimethyl-formamide at 120℃; for 20h; | 64% |
Conditions | Yield |
---|---|
With acetic acid; sodium nitrite In neat (no solvent) at 50℃; for 1h; | 55% |
Conditions | Yield |
---|---|
With tert.-butylnitrite; benzyl-methyl-amine In dimethyl sulfoxide at 110℃; for 12h; | 54% |
ethyl 2-azido-2-(2-bromophenyl)acetate
o-cyanobromobenzene
Conditions | Yield |
---|---|
With oxygen; copper diacetate; potassium carbonate In N,N-dimethyl-formamide at 60℃; under 760.051 Torr; | 47% |
o-cyanobromobenzene
Conditions | Yield |
---|---|
With silica gel In dichloromethane Ambient temperature; | 100% |
Conditions | Yield |
---|---|
With potassium carbonate In water; isopropyl alcohol at 100℃; for 10h; Suzuki-Miyaura Coupling; Inert atmosphere; | 100% |
With potassium phosphate; (dppf)Ni(o-tol)Cl In 1,4-dioxane at 80℃; for 4h; Catalytic behavior; Reagent/catalyst; Solvent; Suzuki-Miyaura Coupling; Sealed tube; | 100% |
With potassium carbonate; palladium dichloride In water; N,N-dimethyl-formamide at 20℃; for 0.1h; Suzuki cross-coupling reaction; | 99% |
o-cyanobromobenzene
4-methylphenylboronic acid
2-Cyano-4'-methylbiphenyl
Conditions | Yield |
---|---|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In 1,4-dioxane; water at 50℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere; | 100% |
With potassium carbonate; [1-cyclohexyl-3-(di-pyridin-2-yl-methyl)-urea][PdCl2] In water at 100℃; for 1h; Suzuki-Miyaura coupling; | 99% |
With potassium carbonate; palladium dichloride In water; N,N-dimethyl-formamide at 20℃; for 0.0833333h; Suzuki cross-coupling reaction; | 99% |
o-cyanobromobenzene
4-methoxyphenylacetylen
2-(2-(4-methoxyphenyl)ethynyl)benzonitrile
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 60℃; | 100% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 50℃; for 2h; Sonogashira Cross-Coupling; Inert atmosphere; | 83% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 50℃; for 2h; Inert atmosphere; |
2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
o-cyanobromobenzene
2'-fluoro-5'-nitrobiphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine In tetrahydrofuran; 1,4-dioxane at 20 - 50℃; for 1.5h; | 100% |
With potassium fluoride; tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine In tetrahydrofuran at 20 - 50℃; |
o-cyanobromobenzene
o-fluorophenylboronic acid
2'-fluoro-[1,1'-biphenyl]-2-carbonitrile
Conditions | Yield |
---|---|
With potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine In tetrahydrofuran; 1,4-dioxane at 20 - 50℃; for 0.75h; | 100% |
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 150℃; for 0.5h; Suzuki cross-coupling; microwave irradiation; | 88% |
With tetrakis(triphenylphosphine) palladium(0); potassium phosphate monohydrate In N,N-dimethyl-formamide at 150℃; for 0.5h; Suzuki coupling; Inert atmosphere; Microwave irradiation; | 81% |
o-cyanobromobenzene
zinc
A
biphenyl-2,2'-dicarbonitrile
B
benzonitrile
C
2-cyanophenylzinc bromide
Conditions | Yield |
---|---|
With trifluoroacetic acid; cobalt(II) bromide; zinc dibromide In acetonitrile the mixt. in CH3CN was stirred at room temp., then arylbromide was added, stirred at room temp.; GC analysis; | A 0% B 0% C 100% |
o-cyanobromobenzene
4-tert-butylphenylboronic acid
Conditions | Yield |
---|---|
With potassium carbonate In water; isopropyl alcohol at 20℃; for 0.0833333h; Catalytic behavior; Suzuki-Miyaura Coupling; Green chemistry; | 100% |
With palladium diacetate; potassium carbonate In water; N,N-dimethyl-formamide at 20℃; for 1h; Suzuki Coupling; | 67% |
With potassium carbonate In water; isopropyl alcohol at 20℃; for 0.0333333h; Catalytic behavior; Suzuki-Miyaura Coupling; | 100 %Chromat. |
With potassium carbonate In water; isopropyl alcohol at 80℃; for 0.5h; Suzuki-Miyaura Coupling; | 45 %Chromat. |
o-cyanobromobenzene
2-Methylphenylboronic acid
2-(o-Tolyl)benzonitrile
Conditions | Yield |
---|---|
With sodium tetrachloropalladate(II); 5-[3-(4-carboxy-2,6-dimethylphenyl)-2-thioxoimidazolidin-1-yl]benzene-1,2,3-tricarboxylic acid; tetrabutylammomium bromide; potassium hydroxide In water at 20℃; for 48h; Suzuki-Miyaura Coupling; Sealed tube; | 99% |
With Pd/C; diisopropylamine In water at 100℃; for 3h; Suzuki Coupling; Green chemistry; | 98% |
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In ethanol; water; toluene at 80℃; Suzuki-Miyaura cross coupling reaction; Inert atmosphere; | 94% |
o-cyanobromobenzene
4-methoxyphenylboronic acid
4'-methoxybiphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With potassium phosphate; [5-(3-butylbenzimidazol-2-yliden-1-yl)-25,26,27,28-tetrapropyloxy calix[4]arene] (pyridine) palladium(II) dibromide In 1,4-dioxane at 100℃; for 24h; Inert atmosphere; | 99% |
With potassium carbonate In water at 80℃; for 10h; Suzuki-Miyaura Coupling; Green chemistry; | 95% |
Stage #1: 4-methoxyphenylboronic acid With potassium phosphate; 2C2F6NO4S2(1-)*C44H66Cl2N2P2Pd(2+); 1-butyl-methylpyrrolidinium bis(trifluoromethylsulfonyl)amide In water at 65℃; Suzuki-Miyaura reaction; Inert atmosphere; Stage #2: o-cyanobromobenzene In water at 65℃; for 2h; Suzuki-Miyaura reaction; Inert atmosphere; | 92% |
With potassium phosphate; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In 1,4-dioxane at 100℃; Suzuki-Miyaura coupling; Inert atmosphere; | 91% |
With palladium diacetate; potassium carbonate In water; N,N-dimethyl-formamide at 20℃; for 1h; Suzuki Coupling; | 68% |
Conditions | Yield |
---|---|
Stage #1: o-cyanobromobenzene With [2,6-η6:η1-bis(2,4,6-trimethylphenyl)phenylthiolato]triethylphosphineruthenium(II)tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; diethylphenylsilane at 20℃; for 18h; Glovebox; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether at 20℃; for 1h; Glovebox; Inert atmosphere; | 99% |
Stage #1: o-cyanobromobenzene With titanium(IV) isopropylate; 1,1,3,3-Tetramethyldisiloxane In toluene at 60℃; for 24h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; | 98% |
Stage #1: o-cyanobromobenzene With 1,1,3,3-Tetramethyldisiloxane; titanium(IV)isopropoxide In methyl cyclohexane at 60℃; for 24h; Inert atmosphere; Stage #2: With hydrogenchloride; water In methyl cyclohexane at 20℃; Inert atmosphere; | 98% |
benzophenone hydrazone
o-cyanobromobenzene
2-(2-(diphenylmethylene)hydrazinyl)benzonitrile
Conditions | Yield |
---|---|
Stage #1: benzophenone hydrazone With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 100℃; for 0.05h; Inert atmosphere; Stage #2: o-cyanobromobenzene With caesium carbonate In toluene at 20 - 100℃; for 7h; Inert atmosphere; | 99% |
Stage #1: benzophenone hydrazone With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 100℃; for 0.25h; Inert atmosphere; Stage #2: o-cyanobromobenzene With caesium carbonate In toluene at 100℃; for 43h; Inert atmosphere; | 74% |
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 100℃; for 12h; Inert atmosphere; |
o-cyanobromobenzene
isopropyl zinc bromide
2-Isopropyl-1-benzonitrile
Conditions | Yield |
---|---|
With [1,3-bis(2,6-diisoheptylphenyl)-4,5-dichloroimidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride In tetrahydrofuran; toluene at 0 - 23℃; Reagent/catalyst; Negishi Coupling; Inert atmosphere; Schlenk technique; | 99% |
Stage #1: o-cyanobromobenzene With C40H55Cl5N3Pd In toluene at 0℃; for 0.0833333h; Negishi Coupling; Inert atmosphere; Cooling with ice; Stage #2: isopropyl zinc bromide In tetrahydrofuran; toluene at 23℃; for 0.5h; Inert atmosphere; | 76% |
Conditions | Yield |
---|---|
With 1,1,1,5,5,5-hexafluoroacetylacetone; copper(II) ferrite; caesium carbonate In 1-methyl-pyrrolidin-2-one at 135℃; for 24h; Ullmann Condensation; Inert atmosphere; Schlenk technique; | 99% |
With copper(II) oxide; potassium hydroxide In N,N-dimethyl acetamide at 27℃; for 24h; Ullmann Condensation; Inert atmosphere; Sealed tube; | 61% |
o-cyanobromobenzene
2-cyclo-pentylbenzonitrile
Conditions | Yield |
---|---|
With Pd-PEPPSI-IPrAn In tetrahydrofuran; 1,4-dioxane at 0 - 20℃; for 0.5h; Negishi Coupling; Schlenk technique; Inert atmosphere; | 99% |
o-cyanobromobenzene
Conditions | Yield |
---|---|
With potassium carbonate In water; isopropyl alcohol at 20℃; for 0.0166667h; Catalytic behavior; Suzuki-Miyaura Coupling; Green chemistry; | 99% |
With potassium carbonate In water; isopropyl alcohol at 20℃; for 0.05h; Catalytic behavior; Suzuki-Miyaura Coupling; | 94 %Chromat. |
With potassium carbonate In water; isopropyl alcohol at 80℃; for 0.5h; Suzuki-Miyaura Coupling; | 65 %Chromat. |
o-cyanobromobenzene
phenylmanganese(II) chloride
biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
1,2-dimethoxyethane; bis(diphenylphosphino)propanepalladium(II) dichloride In tetrahydrofuran at 20℃; for 3h; | 98% |
o-cyanobromobenzene
4-methoxyphenylmagnesium chloride
4'-methoxybiphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 4-methoxyphenylmagnesium chloride With 2-iodo-propane In tetrahydrofuran at 25℃; for 0.0833333h; Inert atmosphere; Stage #2: o-cyanobromobenzene With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride In tetrahydrofuran at 25℃; for 0.0833333h; Kumada coupling reaction; Inert atmosphere; | 98% |
Stage #1: 4-methoxyphenylmagnesium chloride With N,N,N,N,-tetramethylethylenediamine; zinc(II) chloride In tetrahydrofuran at 80℃; for 0.25h; microwave irradiation; Stage #2: o-cyanobromobenzene; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran at 120℃; for 0.0333333h; Negishi cross-coupling; microwave irradiation; | 92% |
o-cyanobromobenzene
3-Aminophenylboronic acid
3'-aminobiphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane at 80℃; for 20h; Suzuki coupling; | 98% |
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane at 80℃; for 20h; | 98% |
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 80℃; for 20h; | 98% |
o-cyanobromobenzene
A
3'-aminobiphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With sodium carbonate; tetrakis(triphenylphosphine)palladium (0) In 1,2-dimethoxyethane; ethyl acetate | A n/a B 98% |
Conditions | Yield |
---|---|
With [RuH(tBu-PNP(-))(CO)]; water In tert-butyl alcohol at 50℃; for 48h; | 98% |
With Wilkinson's catalyst; Acetaldehyde oxime In toluene at 110℃; | 90% |
With Wilkinson's catalyst; Acetaldehyde oxime In toluene at 110℃; for 4h; | 90% |
o-cyanobromobenzene
2-fluoro-3-(trimethylsilanyl)phenylboronic Acid
2′-fluoro-3′-(trimethylsilanyl)biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With palladium diacetate; sodium carbonate; triphenylphosphine In 1,2-dimethoxyethane; water at 90℃; for 14h; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
Stage #1: bromoacetic acid tert-butyl ester With zinc In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Sealed tube; Stage #2: o-cyanobromobenzene With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 20℃; for 4h; Inert atmosphere; Sealed tube; | 98% |
Conditions | Yield |
---|---|
With sodium hydroxide In neat (no solvent) at 80℃; for 1.5h; | 98% |
Conditions | Yield |
---|---|
With potassium phosphate; benzoin oxime; copper diacetate In dimethyl sulfoxide at 80℃; Inert atmosphere; | 98% |
With quebrachitol; copper; caesium carbonate In water; dimethyl sulfoxide at 110℃; for 24h; Ullmann Condensation; Inert atmosphere; Green chemistry; | 89% |
With D-galacturonic acid; potassium carbonate; copper(I) bromide In water; dimethyl sulfoxide at 80 - 100℃; Inert atmosphere; Green chemistry; | 87% |
With copper(I) oxide; caesium carbonate; N-phenyl-2-pyridincarboxamide-1-oxide In dimethyl sulfoxide at 120℃; for 20h; Catalytic behavior; Solvent; Temperature; Inert atmosphere; | 70% |
o-cyanobromobenzene
A
3'-aminobiphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With sodium carbonate; tetrakis(triphenylphosphine)palladium (0) In 1,2-dimethoxyethane; ethyl acetate | A n/a B 98% |
o-cyanobromobenzene
2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]furan
2-(2-benzofuranyl)-benzonitrile
Conditions | Yield |
---|---|
With C35H47O3P*C15H16N(1-)*CH3O3S(1-)*Pd(2+); triethylamine In water at 45℃; for 12h; Suzuki-Miyaura Coupling; | 98% |
benzaldehyde p-toluenesulfonylhydrazone
o-cyanobromobenzene
4-(2-bromophenyl)-5-phenyl-2H-1,2,3-triazole
Conditions | Yield |
---|---|
With potassium tert-butylate In 5,5-dimethyl-1,3-cyclohexadiene at 90℃; for 4h; Inert atmosphere; | 98% |
1-[(4-methoxyphenyl)sulfanyl]pyrrolidine-2,5-dione
o-cyanobromobenzene
2-((4-methoxyphenyl)thio)benzonitrile
Conditions | Yield |
---|---|
With N,N,N'N'-tetramethyl-1,3-propanediamine; trimethoxonium tetrafluoroborate; copper(II) trifluoroacetate; 1,2-bis-(diphenylphosphino)ethane In acetonitrile at 80℃; for 3h; Reagent/catalyst; | 97.7% |
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