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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Propanedinitrile,2,2-dimethyl-

Cas:7321-55-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Propanedinitrile, 2, 2-Dimethyl-

Cas:7321-55-3

Min.Order:1 Metric Ton

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Type:Manufacturers

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 7321-55-3 with best quality

Cas:7321-55-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

Min.Order:10 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Propanedinitrile,2,2-dimethyl-

Cas:7321-55-3

Min.Order:1 Gram

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Qingdao Beluga Import and Export Co., LTD

DIMETHYLMALONONITRILE CAS:7321-55-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

DIMETHYLMALONONITRILE CAS:7321-55-3

Cas:7321-55-3

Min.Order:1 Gram

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Propanedinitrile,2,2-dimethyl-

Cas:7321-55-3

Min.Order:1 Kilogram

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:7321-55-3

Cas:7321-55-3

Min.Order:0

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Propanedinitrile,2,2-dimethyl-

Cas:7321-55-3

Min.Order:0

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,2-dimethylpropanedinitrile

Cas:7321-55-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

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Henan Tianfu Chemical Co., Ltd.

2,2-Dicymalpropane;2,2-Dimethylmalononitrile;dimethylpropanedinitrile;Malononitrile, dimethyl-;malononitrile,dimethyl-;propanedinitrile,dimethyl-;DIMETHYLMALONONITRILE;2,2-Dimethylpropanedinitrile CAS No.: 7321-55-3 Molecular formula: C5H6N2

2,2-Dicymalpropane

Cas:7321-55-3

Min.Order:100 Gram

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

Min.Order:1 Gram

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

Min.Order:1 Metric Ton

FOB Price: $1.5

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

7321-55-3

Cas:7321-55-3

Min.Order:0

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

Min.Order:1 Metric Ton

FOB Price: $1.0

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Win-Win chemical Co.Ltd

Stock products, own laboratoryAppearance:Colorless to light yellow liquid Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2,2-dimethylpropanedinitrile cas no. 7321-55-3 97%

Cas:7321-55-3

Min.Order:0

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Propanedinitrile,2,2-dimethyl-

Cas:7321-55-3

Min.Order:0

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Hubei Langyou International Trading Co., Ltd

2,2-DicyanopropaneCAS:7321-55-3 Application:2,2-DicyanopropaneCAS:7321-55-3

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

Min.Order:0

Negotiable

Type:Other

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Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

7321-55-3

Cas:7321-55-3

Min.Order:0

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Hangzhou Fandachem Co.,Ltd

Propanedinitrile,2,2-dimethyl- cas 7321-55-3Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Propanedinitrile,2,2-dimethyl- cas 7321-55-3

Cas:7321-55-3

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

DIMETHYLMALONONITRILE

Cas:7321-55-3

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Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri

2,2-Dicyanopropane

Cas:7321-55-3

Min.Order:0

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Wuhan Newgreat Chemical Co., Ltd

Wuhan Xinweiye Chemical Co., Ltd. is mainly engaged in the process development and production of customized synthesis and pharmaceutical intermediates. We have professional researchers in organic synthesis, analytical chemistry and production process

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

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Hunan Longxianng Runhui Trading Co.,Ltd

2,2-DicyanopropaneCAS:7321-55-3Appearance:White solid at room temperature Storage:Store in dry, dark and ventilated plac Package:Fluorine fluoride Application:Organic synthetic intermediate biotechnique and some of the other chemicals Transportation

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

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Saiwante (shanghai) New Material Technology Co., Ltd.

Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

Min.Order:0

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Chemlyte Solutions

factory?direct?sale Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents

2,2-DicyanopropaneCAS:7321-55-3

Cas:7321-55-3

Min.Order:0

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Type:Other

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Application:Medical or chemical

7321-55-3

Cas:7321-55-3

Min.Order:0

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Synthetic route

malononitrile
109-77-3

malononitrile

methyl iodide
74-88-4

methyl iodide

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

Conditions
ConditionsYield
With potassium tert-butylate; tetrabutylammomium bromide for 2h; Ambient temperature;76%
With potassium carbonate In acetonitrile at 20℃; for 16h; Inert atmosphere;52%
at 100℃; aus Natriummalonnitril;
With sodium hydride In dimethyl sulfoxide
methyl bromide
74-83-9

methyl bromide

malononitrile
109-77-3

malononitrile

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

Conditions
ConditionsYield
Stage #1: malononitrile With lithium hydroxide In tetrahydrofuran at 5 - 20℃; for 3h; Autoclave;
Stage #2: methyl bromide In tetrahydrofuran at 0 - 20℃; for 8h; Autoclave;
46.5%
2-cyano-2-methylpropanamide
7505-93-3

2-cyano-2-methylpropanamide

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

Conditions
ConditionsYield
With phosphorus pentaoxide at 170℃;
dimethylsulfonium dicyanomethylide
5362-78-7

dimethylsulfonium dicyanomethylide

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

Conditions
ConditionsYield
With triphenylphosphine
malononitrile
109-77-3

malononitrile

methyl iodide
74-88-4

methyl iodide

A

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

B

methylisonitrile

methylisonitrile

Conditions
ConditionsYield
at -10℃; aus Silbermalonnitril nach Beendigung der ersten heftigen Reaktion bei 50grad;
methyl iodide
74-88-4

methyl iodide

disilver-salt of malonic acid dinitrile

disilver-salt of malonic acid dinitrile

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

methyl iodide
74-88-4

methyl iodide

disodium-salt of malonic acid dinitrile

disodium-salt of malonic acid dinitrile

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

3-hydroxy-2,2-dimethylpropionitrile
19295-57-9

3-hydroxy-2,2-dimethylpropionitrile

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.42 h / -78 °C
1.2: -78 - 25 °C
2.1: methanol; water; hydrogenchloride / 1 h / 55 °C
3.1: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 0.25 h / 25 °C
View Scheme
2,2-dimethyl-3-oxopropanenitrile
19295-56-8

2,2-dimethyl-3-oxopropanenitrile

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol; water; hydrogenchloride / 1 h / 55 °C
2: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 0.25 h / 25 °C
View Scheme
2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine
1401327-14-7

2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine

A

formaldehyd
50-00-0

formaldehyd

B

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

C

uridine
58-96-8

uridine

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In dimethyl sulfoxide at 25℃; for 0.25h;
2,2-dimethyl-3-hydroxypropionaldehyde
597-31-9

2,2-dimethyl-3-hydroxypropionaldehyde

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate; water; hydroxylamine hydrochloride / ethanol / 48 h / 70 °C / Cooling with ice
2.1: trifluoroacetic anhydride / -15 °C / Reflux
3.1: methanol / 16 h / 25 °C
4.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.42 h / -78 °C
4.2: -78 - 25 °C
5.1: methanol; water; hydrogenchloride / 1 h / 55 °C
6.1: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 0.25 h / 25 °C
View Scheme
3-hydroxy-2,2-dimethylpropionaldoxime
36559-87-2

3-hydroxy-2,2-dimethylpropionaldoxime

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trifluoroacetic anhydride / -15 °C / Reflux
2.1: methanol / 16 h / 25 °C
3.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.42 h / -78 °C
3.2: -78 - 25 °C
4.1: methanol; water; hydrogenchloride / 1 h / 55 °C
5.1: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 0.25 h / 25 °C
View Scheme
C7H8F3NO2

C7H8F3NO2

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: methanol / 16 h / 25 °C
2.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.42 h / -78 °C
2.2: -78 - 25 °C
3.1: methanol; water; hydrogenchloride / 1 h / 55 °C
4.1: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 0.25 h / 25 °C
View Scheme
3,4-dihydro-isoquinoline 2-oxide
24423-87-8

3,4-dihydro-isoquinoline 2-oxide

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

2-(5,9b-Dihydro-4H-3-oxa-1,3a-diaza-cyclopenta[a]naphthalen-2-yl)-2-methyl-propionitrile
121994-34-1

2-(5,9b-Dihydro-4H-3-oxa-1,3a-diaza-cyclopenta[a]naphthalen-2-yl)-2-methyl-propionitrile

Conditions
ConditionsYield
In toluene at 100℃; for 1h;100%
In toluene at 100℃; Rate constant; two other solvents;
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

2-oxo-3-(ethoxycarbonyl)-3,4-dihydro-β-carboline
106544-20-1

2-oxo-3-(ethoxycarbonyl)-3,4-dihydro-β-carboline

2-(1-cyano-1-methylethyl)-5-(ethoxycarbonyl)-4,5,6,11b-tetrahydro-Δ4-1,2,4-oxadiazolino<3,2-a>-β-carboline
106544-23-4

2-(1-cyano-1-methylethyl)-5-(ethoxycarbonyl)-4,5,6,11b-tetrahydro-Δ4-1,2,4-oxadiazolino<3,2-a>-β-carboline

Conditions
ConditionsYield
In toluene at 80℃; for 1h;100%
In toluene at 80℃; for 1.5h;99%
In 2-methoxy-ethanol at 100℃; Rate constant;
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

L-Phenylalaninol
3182-95-4

L-Phenylalaninol

(4S,4S')-(-)-2,2'-(1-methylethylidene)bis[4,5-dihydro-4-(phenylmethyl)oxazole]
176706-98-2

(4S,4S')-(-)-2,2'-(1-methylethylidene)bis[4,5-dihydro-4-(phenylmethyl)oxazole]

Conditions
ConditionsYield
With zinc trifluoromethanesulfonate In toluene for 48h; Heating;100%
With zinc(II) chloride In chlorobenzene for 24h; Inert atmosphere; Reflux;75%
With zinc(II) chloride In chlorobenzene for 72h; Reflux;24%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

(1R,2S)-1-Amino-2-indanol
136030-00-7

(1R,2S)-1-Amino-2-indanol

(3aR,3a'R,8aS,8a'S)-2,2'-(propane-2,2-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole)

(3aR,3a'R,8aS,8a'S)-2,2'-(propane-2,2-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole)

Conditions
ConditionsYield
With zinc trifluoromethanesulfonate In toluene for 48h; Heating;100%
Stage #1: 2,2-dimethylmalononitrile With zinc trifluoromethanesulfonate In toluene for 0.0833333h; Inert atmosphere;
Stage #2: (1R,2S)-1-Amino-2-indanol In toluene for 24h; Reflux; Inert atmosphere;
71%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

3-(4-methoxyphenyl)-2,2-dimethyl-3-oxopropanenitrile
118362-74-6

3-(4-methoxyphenyl)-2,2-dimethyl-3-oxopropanenitrile

Conditions
ConditionsYield
Stage #1: 2,2-dimethylmalononitrile; 4-methoxyphenylboronic acid With [Rh(OH)(cod)]2; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,4-dioxane at 80℃; for 6h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In 1,4-dioxane; tert-butyl methyl ether Inert atmosphere;
99%
With 4,4'-dimethyl-2,2'-bipyridines; palladium(II) acetylacetonate; toluene-4-sulfonic acid In water; toluene at 80℃; for 24h; Schlenk technique;75%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

benzyl bromide
100-39-0

benzyl bromide

phenylacetonitrile
140-29-4

phenylacetonitrile

2-benzyl-2-phenylmalononitrile
861356-28-7

2-benzyl-2-phenylmalononitrile

Conditions
ConditionsYield
Stage #1: phenylacetonitrile With methylmagnesium bromide; lithium chloride In tetrahydrofuran; diethyl ether at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran; diethyl ether at 80℃; for 6h; Inert atmosphere;
Stage #3: benzyl bromide In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere;
99%
pentanonitrile
110-59-8

pentanonitrile

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

benzyl bromide
100-39-0

benzyl bromide

2-benzyl-2-propylmalononitrile

2-benzyl-2-propylmalononitrile

Conditions
ConditionsYield
Stage #1: pentanonitrile With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran; hexane at 20 - 80℃; for 6h; Inert atmosphere;
Stage #3: benzyl bromide In tetrahydrofuran; hexane; N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere;
98%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

4-methoxybenzonitrile
874-90-8

4-methoxybenzonitrile

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate In 1,4-dioxane at 100℃; for 6h; Inert atmosphere;97%
(2S)-2-amino-3-(diphenylphosphoryl)-propan-1-ol
943599-11-9

(2S)-2-amino-3-(diphenylphosphoryl)-propan-1-ol

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

2,2-bis[(4S)-4-(diphenylphosphinoyl)methyl-1,3-oxazolin-2-yl]propane

2,2-bis[(4S)-4-(diphenylphosphinoyl)methyl-1,3-oxazolin-2-yl]propane

Conditions
ConditionsYield
Stage #1: (2S)-2-amino-3-(diphenylphosphoryl)-propan-1-ol; 2,2-dimethylmalononitrile With zinc(II) chloride In chlorobenzene for 24h; Heating;
Stage #2: With ethylenediamine In water; chlorobenzene for 1h; Further stages.;
96%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

2-mesitylmagnesium bromide
2633-66-1

2-mesitylmagnesium bromide

cyanomesitylene
2571-52-0

cyanomesitylene

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 23℃; for 0.5h;96%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

6-bromo-1,4-benzodioxane
52287-51-1

6-bromo-1,4-benzodioxane

2,3-dihydrobenzo[b][1,4]dioxine-6-carbonitrile
19102-07-9

2,3-dihydrobenzo[b][1,4]dioxine-6-carbonitrile

Conditions
ConditionsYield
Stage #1: 6-bromo-1,4-benzodioxane With magnesium; lithium chloride In tetrahydrofuran at 23℃;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran at 0 - 23℃; for 0.5h;
96%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

dimethyl 2,2-di(prop-2-ynyl)malonate
63104-44-9

dimethyl 2,2-di(prop-2-ynyl)malonate

3-(cyanodimethylmethyl)-5,7-dihydro-[2]pyrindine-6,6-dicarboxylic acid dimethyl ester

3-(cyanodimethylmethyl)-5,7-dihydro-[2]pyrindine-6,6-dicarboxylic acid dimethyl ester

Conditions
ConditionsYield
With tetraethylammonium chloride; tris(acetonitrile)pentamethylcyclopentadienylruthenium(II) hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.16h;95%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

phenylboronic acid
98-80-6

phenylboronic acid

2,2-dimethyl-3-oxo-3-phenylpropanenitrile
7391-73-3

2,2-dimethyl-3-oxo-3-phenylpropanenitrile

Conditions
ConditionsYield
Stage #1: 2,2-dimethylmalononitrile; phenylboronic acid With [Rh(OH)(cod)]2; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,4-dioxane at 80℃; for 4h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In 1,4-dioxane; tert-butyl methyl ether Reagent/catalyst; Inert atmosphere;
95%
With 4,4'-dimethyl-2,2'-bipyridines; palladium(II) acetylacetonate; toluene-4-sulfonic acid In water; toluene at 80℃; for 24h; Schlenk technique;95%
With 4,4'-dimethyl-2,2'-bipyridines; water; palladium(II) acetylacetonate; benzenesulfonic acid In toluene at 80℃; for 24h;84%
With bis(norbornadiene)rhodium(l)tetrafluoroborate; potassium carbonate In 1,4-dioxane at 80℃; for 24h; Reagent/catalyst; Inert atmosphere;45 %Chromat.
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

4-methylphenylboronic acid
5720-05-8

4-methylphenylboronic acid

2,2-dimethyl-3-oxo-3-(p-tolyl)propanenitrile
118362-75-7

2,2-dimethyl-3-oxo-3-(p-tolyl)propanenitrile

Conditions
ConditionsYield
Stage #1: 2,2-dimethylmalononitrile; 4-methylphenylboronic acid With [Rh(OH)(cod)]2; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,4-dioxane at 80℃; for 6h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In 1,4-dioxane; tert-butyl methyl ether Inert atmosphere;
95%
With 4,4'-dimethyl-2,2'-bipyridines; palladium(II) acetylacetonate; toluene-4-sulfonic acid In water; toluene at 80℃; for 24h; Schlenk technique;90%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

phenylacetonitrile
140-29-4

phenylacetonitrile

methyl iodide
74-88-4

methyl iodide

2-methyl-2-phenylmalononitrile
86164-70-7

2-methyl-2-phenylmalononitrile

Conditions
ConditionsYield
Stage #1: phenylacetonitrile With methylmagnesium bromide; lithium chloride In tetrahydrofuran; diethyl ether at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran; diethyl ether at 80℃; for 6h; Inert atmosphere;
Stage #3: methyl iodide In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere;
95%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

2-cyano-2-methylpropanoic acid
22426-30-8

2-cyano-2-methylpropanoic acid

Conditions
ConditionsYield
enzyme from Synechocystis sp. PCC 6803 In phosphate buffer at 30℃; for 12h;94%
With Bradyrhizobium japonicum strain USDA110 nitrilase bll6402 In phosphate buffer at 30℃; for 24h; pH=7.2;93%
6-Iodochromane
67856-45-5

6-Iodochromane

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

chromane-6-carbonitrile

chromane-6-carbonitrile

Conditions
ConditionsYield
Stage #1: 6-iodo-chroman With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran at 0 - 23℃; for 0.5h;
94%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

4-methylphenylboronic acid
5720-05-8

4-methylphenylboronic acid

para-methylbenzonitrile
104-85-8

para-methylbenzonitrile

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate In 1,4-dioxane at 100℃; for 6h; Inert atmosphere;94%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

(3aS,3a'S,8aR,8a'R)-2,2'-(propane-2,2-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole)

(3aS,3a'S,8aR,8a'R)-2,2'-(propane-2,2-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole)

Conditions
ConditionsYield
With zinc trifluoromethanesulfonate In toluene for 48h; Inert atmosphere; Reflux;93%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

2,4,6-trimethylphenyl bromide
576-83-0

2,4,6-trimethylphenyl bromide

cyanomesitylene
2571-52-0

cyanomesitylene

Conditions
ConditionsYield
Stage #1: 2,4,6-trimethylphenyl bromide With magnesium; lithium chloride In tetrahydrofuran at 23℃;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran at 0 - 23℃; for 0.5h;
93%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

1-bromo-2,6-dimethoxybenzene
16932-45-9

1-bromo-2,6-dimethoxybenzene

2,6-dimethoxybenzonitrile
16932-49-3

2,6-dimethoxybenzonitrile

Conditions
ConditionsYield
Stage #1: 1-bromo-2,6-dimethoxybenzene With magnesium; lithium chloride In tetrahydrofuran at 23℃;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran at 0 - 23℃; for 0.5h;
93%
1-iodo-butane
542-69-8

1-iodo-butane

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

p-methoxybenzylnitrile
104-47-2

p-methoxybenzylnitrile

2-butyl-2-(4-methoxyphenyl)malononitrile

2-butyl-2-(4-methoxyphenyl)malononitrile

Conditions
ConditionsYield
Stage #1: p-methoxybenzylnitrile With methylmagnesium bromide; lithium chloride In tetrahydrofuran; diethyl ether at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran; diethyl ether at 80℃; for 6h; Inert atmosphere;
Stage #3: 1-iodo-butane In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere;
93%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

4-bromo-N,N-dimethylaniline
586-77-6

4-bromo-N,N-dimethylaniline

4-cyano-N,N-dimethylaniline
1197-19-9

4-cyano-N,N-dimethylaniline

Conditions
ConditionsYield
Stage #1: 4-bromo-N,N-dimethylaniline With magnesium; lithium chloride In tetrahydrofuran at 23℃;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran at 0 - 23℃; for 1h;
92%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

3,5-dimethyl-4-fluoro-1-bromobenzene
99725-44-7

3,5-dimethyl-4-fluoro-1-bromobenzene

4-fluoro-3,5-dimethylbenzonitrile
867367-02-0

4-fluoro-3,5-dimethylbenzonitrile

Conditions
ConditionsYield
Stage #1: 3,5-dimethyl-4-fluoro-1-bromobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran; hexane at -78 - 20℃; for 1h;
92%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

3-(4-chlorophenyl)-2,2-dimethyl-3-oxopropanenitrile
118362-76-8

3-(4-chlorophenyl)-2,2-dimethyl-3-oxopropanenitrile

Conditions
ConditionsYield
With 4,4'-dimethyl-2,2'-bipyridines; palladium(II) acetylacetonate; toluene-4-sulfonic acid In water; toluene at 80℃; for 24h; Schlenk technique;92%
Stage #1: 2,2-dimethylmalononitrile; 4-Chlorophenylboronic acid With [Rh(OH)(cod)]2; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,4-dioxane at 80℃; for 6h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In 1,4-dioxane; tert-butyl methyl ether Inert atmosphere;
91%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

(4-acetylaminophenyl)boronic acid
101251-09-6

(4-acetylaminophenyl)boronic acid

N-(4-(2-cyano-2-methylpropanoyl)phenyl)acetamide

N-(4-(2-cyano-2-methylpropanoyl)phenyl)acetamide

Conditions
ConditionsYield
Stage #1: 2,2-dimethylmalononitrile; (4-acetylaminophenyl)boronic acid With [Rh(OH)(cod)]2; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,4-dioxane at 80℃; for 6h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In 1,4-dioxane; tert-butyl methyl ether Inert atmosphere;
92%
ortho-tolylmagnesium bromide
932-31-0

ortho-tolylmagnesium bromide

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

2-Methylbenzonitrile
529-19-1

2-Methylbenzonitrile

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 23℃; for 0.5h;91%
1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

4-methoxybenzonitrile
874-90-8

4-methoxybenzonitrile

Conditions
ConditionsYield
Stage #1: 1-bromo-4-methoxy-benzene With TurboGrignard In tetrahydrofuran; 1,4-dioxane at 0℃; for 48h;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran; 1,4-dioxane at 0 - 23℃; for 0.5h;
91%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

1-bromo-2,4,6-tri-tert-butylbenzene
3975-77-7

1-bromo-2,4,6-tri-tert-butylbenzene

2,4,6-tri-(tert-butyl)benzonitrile
24309-22-6

2,4,6-tri-(tert-butyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 1-bromo-2,4,6-tri-tert-butylbenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran; hexane at -78 - 23℃; for 1h;
91%
2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

1-Naphthylboronic acid
13922-41-3

1-Naphthylboronic acid

2,2-dimethyl-3-(naphthalen-1-yl)-3-oxopropanenitrile

2,2-dimethyl-3-(naphthalen-1-yl)-3-oxopropanenitrile

Conditions
ConditionsYield
With 4,4'-dimethyl-2,2'-bipyridines; palladium(II) acetylacetonate; toluene-4-sulfonic acid In water; toluene at 80℃; for 24h; Schlenk technique;91%
With 6,6'-dimethyl-2,2'-bipyridine; p-nitrobenzenesulfonic acid; water; palladium(II) acetylacetonate In toluene at 95℃; for 20h;86%

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