DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s
Cas:850140-72-6
Min.Order:1 Kilogram
FOB Price: $7.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:850140-72-6
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryHubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good serv
Cas:850140-72-6
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryItems Standard Result Assay 98%min ----------------------------------------------------------------------------------------------
Cas:850140-72-6
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryAfatinib Afatinib Brief Description CAS No.:850140-72-6 MF:C24H25ClFN5O3 MW:485.9384032 Competitive price with high quality Conforms to BP/USP/EP/FCC Afatinib COA ITEM STANDARD
Afatinib CAS No.:850140-72-6 Name: Afatinib Synonyms: BIBW 2992; Tovok; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
Cas:850140-72-6
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:850140-72-6
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:850140-72-6
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:BIBW2992 The alias:Tovok,BIBW 2992 CAS NO: 850140-72-6 Molecular formula:C24H25ClFN5O3 Molecular weight:485.9384 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Secur
Cas:850140-72-6
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:850140-72-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:850140-72-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:850140-72-6
Min.Order:1 Kilogram
FOB Price: $289.0 / 499.0
Type:Trading Company
inquiryChemical Name: Afatinib Cas No.: 850140-72-6 Molecular Structure: Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application: APIs Transportation:By sea
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:850140-72-6
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:850140-72-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:850140-72-6
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryBeluga chemical professional supply Afatinib/BIBW-2992/CAS:850140-72-6 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities
Cas:850140-72-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:850140-72-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:850140-72-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:850140-72-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryafatinib 1.Other name:Doxorubicin CAS:850140-72-6 Specification:EP/USP Stock:Fresh Package:25kg drum Application:850140-72-6
Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao/Shanghai
Cas:850140-72-6
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:850140-72-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermediat
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
afatinib
Conditions | Yield |
---|---|
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With thionyl chloride In 1-methyl-pyrrolidin-2-one at -5 - 0℃; for 0.333333h; Stage #2: 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline In 1-methyl-pyrrolidin-2-one at -5 - 0℃; for 0.25h; | 95% |
With Bromoform; triethylamine; triphenylphosphine In dichloromethane at 25℃; for 1h; Reagent/catalyst; Temperature; | 93% |
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With thionyl chloride In 1-methyl-pyrrolidin-2-one; ethyl acetate at 5℃; Stage #2: 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline In 1-methyl-pyrrolidin-2-one; ethyl acetate at 0℃; Temperature; | 87.4% |
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With thionyl chloride In N,N-dimethyl acetamide at -20 - -15℃; Stage #2: 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline In N,N-dimethyl acetamide; water at -25 - -20℃; | 48 g |
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With thionyl chloride In N,N-dimethyl acetamide at -20 - -10℃; Stage #2: 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline In N,N-dimethyl acetamide at -25 - -20℃; for 0.166667h; Stage #3: In water Alkaline conditions; |
dimethylaminoacetaldehyde-hydrogen sulphite adduct
afatinib
Conditions | Yield |
---|---|
Stage #1: (S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate With lithium chloride In ethanol at -5℃; Stage #2: dimethylaminoacetaldehyde-hydrogen sulphite adduct With potassium hydroxide In ethanol; water for 1h; | 91% |
afatinib
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Temperature; Solvent; | 87.3% |
(2E)-(N,N-dimethylamino)-2-butenoyl chloride
afatinib
Conditions | Yield |
---|---|
With piperidine In tetrahydrofuran at 5 - 40℃; for 9h; Temperature; Reagent/catalyst; Solvent; | 86.1% |
(E)-4-(dimethylamino)-2-butenoic acid methyl ester
afatinib
Conditions | Yield |
---|---|
Stage #1: 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline With trimethylaluminum In hexane; dichloromethane at 20℃; for 2h; Stage #2: (E)-4-(dimethylamino)-2-butenoic acid methyl ester In hexane; dichloromethane at 60℃; for 5h; Solvent; | 98% |
Conditions | Yield |
---|---|
Stage #1: C26H31ClFN4O6P With lithium chloride; potassium hydroxide In ethanol; water at -5 - 10℃; for 2h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; Stage #2: 2-dimethylamino-1-hydroxyethanesulfonic acid sodium salt In ethanol; water at 0 - 18℃; for 7h; Solvent; Reagent/catalyst; Temperature; | 91.7% |
Conditions | Yield |
---|---|
With potassium tert-butylate In tert-butyl alcohol at 50℃; for 1h; Reagent/catalyst; Solvent; | 89% |
Conditions | Yield |
---|---|
Stage #1: dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride In water at 30 - 35℃; for 8.3h; Large scale; Stage #2: diethyl ((4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazoline-6-ylcarbamoyl)methyl)phosphonate With lithium chloride; potassium hydroxide In water at -7 - -5℃; for 2h; Large scale; | 78% |
trans-4-dimethylamino crotonic acid chloride hydrochloride salt
afatinib
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 5℃; | 97.5% |
In 1-methyl-pyrrolidin-2-one; water at -5 - 0℃; for 0.5 - 0.75h; | 87% |
In 1-methyl-pyrrolidin-2-one at -5 - 0℃; | 14.1 g |
(S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate
afatinib
Conditions | Yield |
---|---|
With lithium chloride; potassium hydroxide In ethanol; water at -10℃; for 2h; | 60% |
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane In 1,4-dioxane at 110℃; for 48h; Ullmann-Goldberg Substitution; Inert atmosphere; | 56% |
(S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate
dimethylaminoacetaldehyde diethyl acetal
afatinib
Conditions | Yield |
---|---|
Stage #1: dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride In water at 20 - 30℃; Inert atmosphere; Stage #2: (S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate With lithium chloride; potassium hydroxide In tetrahydrofuran at -15 - 20℃; for 2.5h; Product distribution / selectivity; Inert atmosphere; | 97.7% |
Stage #1: dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride In water at 30 - 35℃; for 8.33333h; Stage #2: (S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate With potassium hydroxide; lithium chloride In tetrahydrofuran; water at -7 - 30℃; for 2.16667h; | 78% |
Stage #1: dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride In water at 30 - 35℃; for 8.33333h; Inert atmosphere; Large scale; Stage #2: With potassium hydroxide In water at -5℃; Large scale; Stage #3: (S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate With lithium chloride In tetrahydrofuran at -7℃; for 1.16667h; Large scale; |
Conditions | Yield |
---|---|
With potassium phosphate; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; palladium diacetate In water; tert-butyl alcohol at 110℃; for 16h; Inert atmosphere; Sealed tube; | 4% |
afatinib
Conditions | Yield |
---|---|
Stage #1: (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride With thionyl chloride In N,N-dimethyl acetamide at -20 - -15℃; Stage #2: 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline In N,N-dimethyl acetamide at -25 - -20℃; | 48 g |
Conditions | Yield |
---|---|
Stage #1: 4-[(3-chloro-4-fluorophenyl)amino]-6-amino-7-((S)-tetrahydrofuran-3-yloxy)quinazoline dihydrochloride With hydrogenchloride In ethyl acetate at 25 - 65℃; for 0.25h; Stage #2: (2E)-(N,N-dimethylamino)-2-butenoyl chloride In 1-methyl-pyrrolidin-2-one at 55 - 60℃; for 3h; Temperature; Solvent; | 35 g |
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 8 h / 80 °C / 3000.3 Torr 2: piperidine / tetrahydrofuran / 9 h / 5 - 40 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: iron; acetic acid / ethyl acetate / 1 h / 70 °C 2.1: tetrahydrofuran / 40 °C 2.2: 2 h / 30 - 40 °C 3.1: lithium chloride; potassium hydroxide / water; ethanol / 2 h / -10 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: acetic acid; iron / tetrahydrofuran; water / 3 h / 25 - 30 °C 1.2: 1.5 h / 0 - 5 °C 2.1: hydrogenchloride / ethyl acetate / 0.25 h / 25 - 65 °C 2.2: 3 h / 55 - 60 °C View Scheme |
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 1,1'-carbonyldiimidazole / dichloromethane / 30 - 55 °C 1.2: 3 h / 20 - 40 °C 2.1: lithium chloride; potassium hydroxide / ethanol; water / 2 h / -5 - 10 °C / Inert atmosphere 2.2: 7 h / 0 - 18 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 40 °C 1.2: 2 h / 30 - 40 °C 2.1: lithium chloride; potassium hydroxide / water; ethanol / 2 h / -10 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: phosphorus trichloride / dichloromethane / 1.5 h / 0 - 20 °C 1.2: 1.5 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C 3.1: sodium tetrahydroborate / ethanol / 1 h / Reflux 4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme |
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium tert-butylate / N,N-dimethyl-d6-formamide / 1 h / 0 °C 1.2: 20 °C 2.1: iron; acetic acid / ethyl acetate / 1 h / 70 °C 3.1: tetrahydrofuran / 40 °C 3.2: 2 h / 30 - 40 °C 4.1: lithium chloride; potassium hydroxide / water; ethanol / 2 h / -10 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: iron(III) chloride / tert-butyl alcohol; acetone / 4 h / Inert atmosphere 2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 40 °C 2.2: 1 h 3.1: potassium hydroxide / tetrahydrofuran; water / 0 - 20 °C 4.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 1-methyl-pyrrolidin-2-one / 0.17 h / 25 - 30 °C / Inert atmosphere 1.2: 1.5 h / 15 - 20 °C 2.1: acetic acid; iron / tetrahydrofuran; water / 3 h / 25 - 30 °C 2.2: 1.5 h / 0 - 5 °C 3.1: hydrogenchloride / ethyl acetate / 0.25 h / 25 - 65 °C 3.2: 3 h / 55 - 60 °C View Scheme |
7-fluoro-6-nitro-3H-quinazolin-4-one
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium t-butanolate / acetonitrile / 2 h / 25 °C / Inert atmosphere 1.2: 18 h / 30 - 100 °C 2.1: phosphorus trichloride / acetonitrile / 10 h / 100 °C 3.1: tributyl-amine / propan-1-ol / 24 h / 60 °C 4.1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 8 h / 80 °C / 3000.3 Torr 5.1: piperidine / tetrahydrofuran / 9 h / 5 - 40 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: trichlorophosphate; triethylamine / acetonitrile / 5 h / 0 - 85 °C 1.2: 3 h / 25 - 30 °C 2.1: 1-methyl-pyrrolidin-2-one / 0.17 h / 25 - 30 °C / Inert atmosphere 2.2: 1.5 h / 15 - 20 °C 3.1: acetic acid; iron / tetrahydrofuran; water / 3 h / 25 - 30 °C 3.2: 1.5 h / 0 - 5 °C 4.1: hydrogenchloride / ethyl acetate / 0.25 h / 25 - 65 °C 4.2: 3 h / 55 - 60 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: trichlorophosphate; triethylamine / acetonitrile 2.1: potassium hydroxide / 1,4-dioxane 3.1: 1-methyl-pyrrolidin-2-one / 0.17 h / 25 - 30 °C / Inert atmosphere 3.2: 1.5 h / 15 - 20 °C 4.1: acetic acid; iron / tetrahydrofuran; water / 3 h / 25 - 30 °C 4.2: 1.5 h / 0 - 5 °C 5.1: hydrogenchloride / ethyl acetate / 0.25 h / 25 - 65 °C 5.2: 3 h / 55 - 60 °C View Scheme |
(E)-4-dimethylamino-but-2-enoic acid tert-butyl ester
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / ethyl acetate / 10 - 25 °C / Inert atmosphere 2: thionyl chloride / 1-methyl-pyrrolidin-2-one / 0.42 - 0.5 h / -5 - 0 °C 3: water; 1-methyl-pyrrolidin-2-one / 0.5 - 0.75 h / -5 - 0 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / water; ethyl acetate / 10 - 25 °C / Inert atmosphere 2: thionyl chloride / 1-methyl-pyrrolidin-2-one / -5 - 0 °C 3: 1-methyl-pyrrolidin-2-one / -5 - 0 °C View Scheme |
3-chloro-4-fluorophenylamine
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 3.5 h / 80 °C 2.1: triphenylphosphine; iodine; triethanolamine / dichloromethane / 1 h / 20 °C 3.1: palladium diacetate; oxygen; caesium carbonate / toluene / 4.5 h / Reflux 4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 10 - 20 °C 5.1: iron; hydrogenchloride; sodium hydroxide / water / 10.5 h / 40 - 80 °C / pH 8 - 9 6.1: trimethylaluminum / dichloromethane; hexane / 2 h / 20 °C 6.2: 5 h / 60 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: trichlorophosphate; triethylamine / acetonitrile / 5 h / 0 - 85 °C 1.2: 3 h / 25 - 30 °C 2.1: 1-methyl-pyrrolidin-2-one / 0.17 h / 25 - 30 °C / Inert atmosphere 2.2: 1.5 h / 15 - 20 °C 3.1: acetic acid; iron / tetrahydrofuran; water / 3 h / 25 - 30 °C 3.2: 1.5 h / 0 - 5 °C 4.1: hydrogenchloride / ethyl acetate / 0.25 h / 25 - 65 °C 4.2: 3 h / 55 - 60 °C View Scheme |
7-fluoro-3H-quinazolin-4-one
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium hydride / mineral oil / 0.33 h / 0 - 20 °C 1.2: 16 h / 130 °C 2.1: bromine / chloroform / 64 h / 0 - 20 °C / Inert atmosphere 3.1: thionyl chloride / N,N-dimethyl-formamide / 16 h / 90 °C 4.1: isopropyl alcohol / 3 h / 100 °C 5.1: dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; potassium phosphate; palladium diacetate / water; tert-butyl alcohol / 16 h / 110 °C / Inert atmosphere; Sealed tube View Scheme | |
Multi-step reaction with 5 steps 1.1: bromine / water / 5 h / 85 °C 2.1: sodium hydride / mineral oil / 0.33 h / 0 - 20 °C 2.2: 2 h / 130 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / 16 h / 90 °C 4.1: isopropyl alcohol / 3 h / 100 °C 5.1: dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; potassium phosphate; palladium diacetate / water; tert-butyl alcohol / 16 h / 110 °C / Inert atmosphere; Sealed tube View Scheme |
6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]-3,4-dihydroquinazoline-4-one
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: phosphorus trichloride / acetonitrile / 10 h / 100 °C 2: tributyl-amine / propan-1-ol / 24 h / 60 °C 3: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 8 h / 80 °C / 3000.3 Torr 4: piperidine / tetrahydrofuran / 9 h / 5 - 40 °C View Scheme |
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tributyl-amine / propan-1-ol / 24 h / 60 °C 2: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 8 h / 80 °C / 3000.3 Torr 3: piperidine / tetrahydrofuran / 9 h / 5 - 40 °C View Scheme |
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: palladium diacetate; oxygen; caesium carbonate / toluene / 4.5 h / Reflux 2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 10 - 20 °C 3.1: iron; hydrogenchloride; sodium hydroxide / water / 10.5 h / 40 - 80 °C / pH 8 - 9 4.1: trimethylaluminum / dichloromethane; hexane / 2 h / 20 °C 4.2: 5 h / 60 °C View Scheme |
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 10 - 20 °C 2.1: iron; hydrogenchloride; sodium hydroxide / water / 10.5 h / 40 - 80 °C / pH 8 - 9 3.1: trimethylaluminum / dichloromethane; hexane / 2 h / 20 °C 3.2: 5 h / 60 °C View Scheme |
5-bromo-2-nitrophenol
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; t-BuBrettPhos / methanol / 2 h / 85 °C 2.1: palladium diacetate; oxygen; caesium carbonate / toluene / 4.5 h / Reflux 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 10 - 20 °C 4.1: iron; hydrogenchloride; sodium hydroxide / water / 10.5 h / 40 - 80 °C / pH 8 - 9 5.1: trimethylaluminum / dichloromethane; hexane / 2 h / 20 °C 5.2: 5 h / 60 °C View Scheme |
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: palladium diacetate; oxygen; caesium carbonate / toluene / 4.5 h / Reflux 2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 10 - 20 °C 3.1: iron; hydrogenchloride; sodium hydroxide / water / 10.5 h / 40 - 80 °C / pH 8 - 9 4.1: trimethylaluminum / dichloromethane; hexane / 2 h / 20 °C 4.2: 5 h / 60 °C View Scheme |
N-(3-chloro-4-fluoro-phenyl)-formamide
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triphenylphosphine; iodine; triethanolamine / dichloromethane / 1 h / 20 °C 2.1: palladium diacetate; oxygen; caesium carbonate / toluene / 4.5 h / Reflux 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 10 - 20 °C 4.1: iron; hydrogenchloride; sodium hydroxide / water / 10.5 h / 40 - 80 °C / pH 8 - 9 5.1: trimethylaluminum / dichloromethane; hexane / 2 h / 20 °C 5.2: 5 h / 60 °C View Scheme |
afatinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 40 °C 1.2: 1 h 2.1: potassium hydroxide / tetrahydrofuran; water / 0 - 20 °C 3.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 50 °C View Scheme |
Conditions | Yield |
---|---|
In tetrahydrofuran; water at 20 - 110℃; | 97% |
afatinib
maleic acid
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; Solvent; Temperature; Concentration; | 96.5% |
In ethanol at 70℃; | 91.5% |
In ethanol at 0 - 50℃; for 5.5h; Temperature; Large scale; | 91% |
afatinib
maleic acid
Conditions | Yield |
---|---|
In ethanol at 70℃; | 94.1% |
In ethanol at 0 - 70℃; for 5h; Solvent; Temperature; Large scale; | 91.5% |
In ethyl acetate at 20 - 30℃; Solvent; Temperature; | 4 g |
afatinib
Conditions | Yield |
---|---|
With sulfuric acid In ethyl acetate at 20℃; Product distribution / selectivity; | 94% |
afatinib
Conditions | Yield |
---|---|
With water; potassium hydroxide In ethanol at 50℃; for 24h; Solvent; Temperature; Reagent/catalyst; | 93.3% |
afatinib
Conditions | Yield |
---|---|
With phosphoric acid In ethyl acetate at 20℃; for 0.866667h; Product distribution / selectivity; | 93% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 0.7h; Product distribution / selectivity; | 92% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 1.03333h; | 80.7% |
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 80℃; for 2h; Temperature; Solvent; | 80.6% |
afatinib
Conditions | Yield |
---|---|
With hydrogenchloride In isopropyl alcohol at 20℃; for 1.31667h; | 80% |
Conditions | Yield |
---|---|
In ethanol at 40℃; for 0.833333h; Reflux; | 78% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 6.5h; | 75.7% |
Conditions | Yield |
---|---|
In ethanol at 20 - 70℃; Product distribution / selectivity; | 67.7% |
Conditions | Yield |
---|---|
In ethanol at 20 - 70℃; | 63.6% |
Conditions | Yield |
---|---|
In ethanol at 20℃; for 0.283333h; | 57% |
afatinib
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 50℃; for 24h; Reagent/catalyst; Temperature; Solvent; | 43% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View