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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:100 Gram

FOB Price: $10.0

Type:Manufacturers

inquiry

Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(S)-(+)-3-Hydroxytetrahydrofuran Manufacturer/High quality/Best price/In stock

Cas:86087-23-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Assay: 99% up; Stable supply with over 50Mt annually; Appearance:White or off-white powder Storage:room temprature Package:1kg/bag, 25kg/drum Application:Intermediate of Empagliflozin Port:Beijing/Shanghai/Shenzhen/Hangzhou

(S)-(+)-3-Hydroxytetrahydrofuran, Intermediate of Empagliflozin

Cas:86087-23-2

Min.Order:1 Kilogram

FOB Price: $875.0 / 955.0

Type:Trading Company

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for (S)-(+)-3-Hydroxytetrahydrofuran Cas 86087-23-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Transparent yellow to light brown liquid Storage:Cool dr

Manufacturer supply (S)-(+)-3-Hydroxytetrahydrofuran Cas 86087-23-2 with high quality and good service

Cas:86087-23-2

Min.Order:1 Kilogram

FOB Price: $480.0 / 530.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

(S)-Tetrahydrofuran-3-ol[CAS:86087-23-2] (S)-(+)-3-Hydroxytetrahydrofuran (S)-(+)-Tetrahydro-3-furanol HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, r

(S)-(+)-3-Hydroxytetrahydrofuran stock

Cas:86087-23-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:intermediate Transportation:According to

86087-23-2(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% (S)-(+)-3-Hydroxytetrahydrofuran 86087-23-2 ISO Producer

Cas:86087-23-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less tha

A(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

(S)-(+)-3-Hydroxytetrahydrofuran -- CHemwill

Cas:86087-23-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

(S)-(+)-3-Hydroxytetrahydrofuran CAS NO.86087-23-2

Cas:86087-23-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1378.html Product Name (S)-(+)-3-Hydroxytetrahydrofuran CAS No. 86087-23-2

(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:1 Gram

FOB Price: $6.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu

(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:1 Gram

FOB Price: $0.4 / 0.5

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and

TIANFU-CHEM (S)-(+)-3-Hydroxytetrahydrofuran 86087-23-2

Cas:86087-23-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 86087-23-2 with best quality

Cas:86087-23-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

(S)-(+)-3-HydroxytetrahydrofuranCAS86087-23-2

Cas:86087-23-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 40.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name S-3-Hydroxytetrahydrofuran CAS NO. 86087-23-2 Molecular formula C4H8O2 Molecular weight 88.10510 Structure

S-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

(S)-(+)-3-HydroxytetrahydrofuranCAS NO.: 86087-23-2

Cas:86087-23-2

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2

Cas:86087-23-2

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(S)-(+)-3-Hydroxytetrahydrofuran 86087-23-2

Cas:86087-23-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:1 Kilogram

FOB Price: $500.0 / 600.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(S)-(+)-3-Hydroxytetrahydrofuran CAS: 86087-23-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

(S)-(+)-3-Hydroxytetrahydrofuran CAS: 86087-23-2

Cas:86087-23-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

(S)-(+)-3-Hydroxytetrahydrofuran cas:86087-23-2

Cas:86087-23-2

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(S)-(+)-3-Hydroxytetrahydrofuran

Cas:86087-23-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:As

(S)-Tetrahydrofuran-3-ol

Cas:86087-23-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(3S)-4-chloro-1,3-butanediol
139013-68-6

(3S)-4-chloro-1,3-butanediol

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In methanol; water99.8%
With potassium hydroxide In methanol at 40℃; for 4h; Reagent/catalyst;97%
In anhydrous ethylene glycol dimethyl ether at 110℃; for 5h; Product distribution / selectivity;90%
4-chloro-3-hydroxy-1-butanol
145873-44-5

4-chloro-3-hydroxy-1-butanol

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With hydrogenchloride In water at 50℃; for 4h; Solvent; Reagent/catalyst;94.6%
(S)-3-(4-Methoxy-benzyloxy)-tetrahydro-furan

(S)-3-(4-Methoxy-benzyloxy)-tetrahydro-furan

A

ethyl p-methoxybenzyl sulfide
83318-92-7

ethyl p-methoxybenzyl sulfide

B

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With aluminium trichloride; ethanethiol In dichloromethane for 5h; Ambient temperature;A n/a
B 93%
(S)-1,2,4-butanetriol
42890-76-6

(S)-1,2,4-butanetriol

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With toluene-4-sulfonic acid (3a preparation above 7a);87%
toluene-4-sulfonic acid In PEG-400 at 120 - 160℃; under 10 Torr; for 12h; Product distribution / selectivity;83%
strong acid ion exchange resin (Amberlyst 15, H+ form) In 1,4-dioxane at 90 - 120℃; under 760.051 - 5931.67 Torr; Product distribution / selectivity;70%
With toluene-4-sulfonic acid
With toluene-4-sulfonic acid In water at 90℃;10 g
(S)-tetrahydrofuran-3-yl acetate

(S)-tetrahydrofuran-3-yl acetate

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 20℃; for 3h;83%
(S)-3-benzyloxytetrahydrofuran

(S)-3-benzyloxytetrahydrofuran

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen at 40℃;81.5%
(R)-3-Hydroxytetrahydrofuran
86087-24-3

(R)-3-Hydroxytetrahydrofuran

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
Stage #1: (R)-3-Hydroxytetrahydrofuran With azodicarboxylic acid bis(2-methoxyethyl) ester; 4-diphenylphosphanobenzoic acid In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: With water; sodium hydroxide In tetrahydrofuran at 20℃; stereospecific reaction;
64%
2-(oxiran-2-yl)ethyl 4-methylbenzenesulfonate
115914-74-4

2-(oxiran-2-yl)ethyl 4-methylbenzenesulfonate

A

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

B

2-((R)-oxiran-2-yl)ethyl 4-methylbenzenesulfonate

2-((R)-oxiran-2-yl)ethyl 4-methylbenzenesulfonate

Conditions
ConditionsYield
With (S,S)-(salen)cobalt(III)(OAc); water In tetrahydrofuran at 0 - 25℃; for 14h; optical yield given as %ee; enantioselective reaction;A 48%
B 47%
2,3-dihydro-2H-furan
1191-99-7

2,3-dihydro-2H-furan

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
Yield given. Multistep reaction;
2,5-dihydrofuran
1708-29-8

2,5-dihydrofuran

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
Multistep reaction;
Yield given. Multistep reaction;
(S)-3-(trichlorosilyl)tetrahydrofuran

(S)-3-(trichlorosilyl)tetrahydrofuran

A

(R)-3-Hydroxytetrahydrofuran
86087-24-3

(R)-3-Hydroxytetrahydrofuran

B

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol for 16h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
4-chloro-3-hydroxy-1-butanol
145873-44-5

4-chloro-3-hydroxy-1-butanol

A

2,5-dihydrofuran
1708-29-8

2,5-dihydrofuran

B

(R)-3-Hydroxytetrahydrofuran
86087-24-3

(R)-3-Hydroxytetrahydrofuran

C

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With hydrogenchloride for 2h; Heating;A 15 % Chromat.
B n/a
C n/a
With hydrogenchloride for 2h; Heating; Yields of byproduct given. Title compound not separated from byproducts;A 15 % Chromat.
B n/a
C n/a
3-Hydroxytetrahydrofuran
453-20-3

3-Hydroxytetrahydrofuran

A

(R)-3-Hydroxytetrahydrofuran
86087-24-3

(R)-3-Hydroxytetrahydrofuran

B

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With vinyl acetate; Candida antarctica B lipase on carrier C3 In hexane at 37℃; for 0.0833333h; Title compound not separated from byproducts;
(+/-)-tetrahydrofuran-3-yl acetate
27999-96-8

(+/-)-tetrahydrofuran-3-yl acetate

A

(R)-3-Hydroxytetrahydrofuran
86087-24-3

(R)-3-Hydroxytetrahydrofuran

B

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With sodium phosphate buffer; esterase B from Candida antarctica In water at 37℃; for 1h; pH=7.3; Product distribution;
(2S)-2-tert-Butoxy-1,4-butanediol
167971-73-5

(2S)-2-tert-Butoxy-1,4-butanediol

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 18 - 77℃; under 12.5 - 15 Torr;
3-Hydroxytetrahydrofuran
453-20-3

3-Hydroxytetrahydrofuran

vinyl acetate
108-05-4

vinyl acetate

A

(R)-3-Hydroxytetrahydrofuran
86087-24-3

(R)-3-Hydroxytetrahydrofuran

B

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

C

(R)-tetrahydrofuran-3-yl acetate

(R)-tetrahydrofuran-3-yl acetate

D

(S)-tetrahydrofuran-3-yl acetate

(S)-tetrahydrofuran-3-yl acetate

Conditions
ConditionsYield
With EL-14 lipase In hexane at 4℃; for 16h; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;
but-3-enyl 4-methylbenzenesulfonate
778-29-0

but-3-enyl 4-methylbenzenesulfonate

A

(R)-3-Hydroxytetrahydrofuran
86087-24-3

(R)-3-Hydroxytetrahydrofuran

B

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With potassium osmate(VI) dihydrate; methanesulfonamide; water; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III) In tert-butyl alcohol at 0℃; for 6h; Sharpless asymmetric dihydroxylation; optical yield given as %ee;
(+/-)-tetrahydrofuran-3-yl acetate
27999-96-8

(+/-)-tetrahydrofuran-3-yl acetate

A

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

B

(R)-tetrahydrofuran-3-yl acetate

(R)-tetrahydrofuran-3-yl acetate

Conditions
ConditionsYield
With crude extract of Escherichia coli DH5α cells containing Bacillus stearothermophilus esterase, D31T/L93F mutant In aq. phosphate buffer at 37℃; for 42h; pH=7.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;
tetrahydrofuran-3-one
22929-52-8

tetrahydrofuran-3-one

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With nicotinamide adenine dinucleotide In aq. phosphate buffer; acetonitrile at 30℃; for 4h; pH=7.4; Kinetics; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;n/a
With alcohol dehydrogenase fromThermoanaerobacter brockii, A85V/I86L/L294Q mutant; NADP; lysozyme; DNase I In isopropyl alcohol at 30℃; for 16h; Enzymatic reaction; stereoselective reaction;n/a
C7H18NO2(1+)*Cl(1-)

C7H18NO2(1+)*Cl(1-)

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With sodium hydroxide In dimethyl sulfoxide at 170 - 190℃; Reagent/catalyst; Inert atmosphere;
tetrahydrofuran-3-one
22929-52-8

tetrahydrofuran-3-one

A

(R)-3-Hydroxytetrahydrofuran
86087-24-3

(R)-3-Hydroxytetrahydrofuran

B

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Conditions
ConditionsYield
With alcohol dehydrogenase fromThermoanaerobacter brockii, A85V/I86L/L294H mutant; NADP; lysozyme; DNase I In isopropyl alcohol at 30℃; for 16h; Enzymatic reaction; stereoselective reaction;A n/a
B n/a
With alcohol dehydrogenase fromThermoanaerobacter brockii, L294C mutant; NADP; lysozyme; DNase I In isopropyl alcohol at 30℃; for 16h; Enzymatic reaction; stereoselective reaction;A n/a
B n/a
di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione
138499-08-8

1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 18h;100%
With triethylamine In acetonitrile at 20℃; for 18h;100%
With triethylamine In acetonitrile at 20℃; for 21.5h;94%
(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

3-cyanocarbonyl-3'-methoxycarbonyl-2,2'-binaphthalene

3-cyanocarbonyl-3'-methoxycarbonyl-2,2'-binaphthalene

[2,2']Binaphthalenyl-1,3'-dicarboxylic acid 1-methyl ester 3'-(S)-(tetrahydro-furan-3-yl) ester

[2,2']Binaphthalenyl-1,3'-dicarboxylic acid 1-methyl ester 3'-(S)-(tetrahydro-furan-3-yl) ester

Conditions
ConditionsYield
With dmap In acetonitrile at 20℃;100%
(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

Carbonic acid (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester 4-nitro-phenyl ester
229495-94-7

Carbonic acid (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester 4-nitro-phenyl ester

Carbonic acid (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester (S)-(tetrahydro-furan-3-yl) ester
229495-71-0

Carbonic acid (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester (S)-(tetrahydro-furan-3-yl) ester

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane for 48h; Heating;100%
3-hydroxy-5-(4-methanesulfonylphenoxy)benzoic acid methyl ester
752242-45-8

3-hydroxy-5-(4-methanesulfonylphenoxy)benzoic acid methyl ester

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

C19H20O7S
1001420-25-2

C19H20O7S

Conditions
ConditionsYield
With 4,4-(dimethyl-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)-triphenyl phosphonium In dichloromethane; toluene at 20℃; for 15h;100%
(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

toluene-4-sulfonic acid (S)-(tetrahydrofuran-3-yl)ester
112052-11-6

toluene-4-sulfonic acid (S)-(tetrahydrofuran-3-yl)ester

Conditions
ConditionsYield
With 1H-imidazole; dmap In dichloromethane at 20℃; for 16h;100%
With pyridine100%
With trimethylamine hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 4h;99%
(3-fluoro-2-hydroxy-5-nitro-benzyl)-methyl-carbamic acid tert-butyl ester
1037093-11-0

(3-fluoro-2-hydroxy-5-nitro-benzyl)-methyl-carbamic acid tert-butyl ester

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(R)-tert-butyl 3-fluoro-5-nitro-2-((tetrahydrofuran-3-yl)oxy)benzyl(methyl)carbamate
1508296-65-8

(R)-tert-butyl 3-fluoro-5-nitro-2-((tetrahydrofuran-3-yl)oxy)benzyl(methyl)carbamate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 16.5h;100%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(S)-tetrahydrofuran-3-yl trifluoromethanesulfonate

(S)-tetrahydrofuran-3-yl trifluoromethanesulfonate

Conditions
ConditionsYield
Stage #1: trifluoromethylsulfonic anhydride With N-ethyl-N,N-diisopropylamine In dichloromethane at -78℃; for 0.0833333h; Inert atmosphere;
Stage #2: (S)-3-hydroxytetyrahydrofurane In dichloromethane at -78 - 20℃; for 3h; Inert atmosphere;
100%
With pyridine In dichloromethane at -10℃; for 0.5h;
(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
162012-67-1

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

Conditions
ConditionsYield
Stage #1: (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h;
Stage #2: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine In tetrahydrofuran at 20℃; for 3h;
99.5%
Stage #1: (S)-3-hydroxytetyrahydrofurane With sodium hydride In tetrahydrofuran; mineral oil for 0.75h; Cooling with ice;
Stage #2: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine In tetrahydrofuran at 20℃; for 5h;
99.5%
Stage #1: (S)-3-hydroxytetyrahydrofurane With sodium hydride In tetrahydrofuran; mineral oil for 0.75h; Cooling with ice;
Stage #2: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine In tetrahydrofuran; mineral oil at 20℃; for 5h;
99.5%
4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-fluoroquinazoline

4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-fluoroquinazoline

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

4-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

4-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

Conditions
ConditionsYield
Stage #1: (S)-3-hydroxytetyrahydrofurane With sodium hydride In tetrahydrofuran; mineral oil for 0.75h; Cooling with ice;
Stage #2: 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-fluoroquinazoline In tetrahydrofuran; mineral oil at 20℃; for 5h;
99.5%
1-(2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one
1309831-35-3

1-(2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

1-(2-((S)-tetrahydrofuran-3-yloxy)-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

1-(2-((S)-tetrahydrofuran-3-yloxy)-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Conditions
ConditionsYield
Stage #1: (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: 1-(2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one In tetrahydrofuran at 0 - 20℃; for 2.16667h;
98%
4-((3-chloro-4-fluorophenyl)amino)-6-nitro-7-chloroquinazoline
179552-73-9

4-((3-chloro-4-fluorophenyl)amino)-6-nitro-7-chloroquinazoline

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

Conditions
ConditionsYield
Stage #1: (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In N,N-dimethyl-formamide at 0℃; for 2h;
Stage #2: 7-chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine With sodium benzenesulfonate In N,N-dimethyl-formamide at 30 - 90℃; for 6h;
97.8%
With potassium tert-butylate; sodium methansulfinate In N,N-dimethyl-formamide at 80℃; for 3h; Reagent/catalyst; Solvent; Temperature;93%
2-(chloromethyl)-4-hydroxy-5,8-dihydropyridine[3,4-d]pyrimidine-7(6H)-carboxylic acid tert-butyl ester

2-(chloromethyl)-4-hydroxy-5,8-dihydropyridine[3,4-d]pyrimidine-7(6H)-carboxylic acid tert-butyl ester

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

3(S)-4-hydroxy-2-(((tetrahydrofuran-3-yl)oxy)methyl)-5,8-dihydropyridin[3,4-d]pyrimidine-7(6H)-carboxylic acid tert butyl ester

3(S)-4-hydroxy-2-(((tetrahydrofuran-3-yl)oxy)methyl)-5,8-dihydropyridin[3,4-d]pyrimidine-7(6H)-carboxylic acid tert butyl ester

Conditions
ConditionsYield
Stage #1: (S)-3-hydroxytetyrahydrofurane With sodium hydride In N,N-dimethyl-formamide for 0.5h;
Stage #2: 2-(chloromethyl)-4-hydroxy-5,8-dihydropyridine[3,4-d]pyrimidine-7(6H)-carboxylic acid tert-butyl ester In N,N-dimethyl-formamide at 20℃; for 1h;
97%
(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

[(3S)-tetrahydrofuran-3-yl] methanesulfonate
347885-35-2

[(3S)-tetrahydrofuran-3-yl] methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 1h; Cooling with ice;96%
With triethylamine In dichloromethane at 20℃; Cooling with ice;83%
With triethylamine In dichloromethane at 0℃; for 4h;80%
methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate
1355011-30-1

methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

methyl 6-{2,6-difluoro-4-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-5-fluoropyridine-2-carboxylate
1395992-69-4

methyl 6-{2,6-difluoro-4-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-5-fluoropyridine-2-carboxylate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;96%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 2h;96%
(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

toluene-4-sulfonic acid (S)-(tetrahydrofuran-3-yl)ester
112052-11-6

toluene-4-sulfonic acid (S)-(tetrahydrofuran-3-yl)ester

Conditions
ConditionsYield
Stage #1: (S)-3-hydroxytetyrahydrofurane With dmap; triethylamine In dichloromethane at 0℃; for 0.166667h;
Stage #2: toluene-4-sulfonic acid at 20 - 50℃; for 1.66667h;
96%
4-hydroxybenzyl chloride
35421-08-0

4-hydroxybenzyl chloride

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(3S)-3-[p-(chloromethyl)phenoxy]tetrahydrofuran

(3S)-3-[p-(chloromethyl)phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Stage #1: 4-hydroxybenzyl chloride In dichloromethane at -5 - 0℃; for 3h;
Stage #2: (S)-3-hydroxytetyrahydrofurane With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 4.5h; Reagent/catalyst; Reflux;
95.3%
(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

(S)-3-(4-nitrophenoxy)tetrahydrofuran

(S)-3-(4-nitrophenoxy)tetrahydrofuran

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 20 - 25℃; for 1h; Inert atmosphere;95%
C12H11Cl3N2O

C12H11Cl3N2O

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

C16H18Cl2N2O3

C16H18Cl2N2O3

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃;94.3%
fluorobenzene
462-06-6

fluorobenzene

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(S)-3-phenoxytetrahydrofuran

(S)-3-phenoxytetrahydrofuran

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol at 0 - 10℃; for 1.5h; Inert atmosphere; Large scale;94%
With potassium tert-butylate In tetrahydrofuran at 0 - 10℃; for 1h; Inert atmosphere; Large scale;94%
(2-chloro-5-bromophenyl)(4-fluorophenyl)methanone
915095-85-1

(2-chloro-5-bromophenyl)(4-fluorophenyl)methanone

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(S)-(5-bromo-2-chlorophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-84-0

(S)-(5-bromo-2-chlorophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃;93%
With potassium tert-butylate In tetrahydrofuran at 7 - 10℃; for 0.5h;87%
With potassium tert-butylate In tetrahydrofuran at 0 - 10℃; for 2h;85.3%
6-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylquinazolin-8-ol

6-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylquinazolin-8-ol

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(S)-6-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-8-((tetrahydrofuran-3-yl)oxy)quinazoline

(S)-6-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-8-((tetrahydrofuran-3-yl)oxy)quinazoline

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu Displacement; Inert atmosphere;93%
(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

1-bromo-3-(bromomethyl)-2-fluorobenzene
149947-16-0

1-bromo-3-(bromomethyl)-2-fluorobenzene

(S)-3-((3-bromo-2-fluorobenzyl)oxy)tetrahydrofuran

(S)-3-((3-bromo-2-fluorobenzyl)oxy)tetrahydrofuran

Conditions
ConditionsYield
Stage #1: (S)-3-hydroxytetyrahydrofurane With sodium hydride In N,N-dimethyl-formamide for 1h; Inert atmosphere;
Stage #2: 1-bromo-3-(bromomethyl)-2-fluorobenzene In N,N-dimethyl-formamide for 17h; Inert atmosphere;
92.51%
C20H18ClF2N5O

C20H18ClF2N5O

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

Conditions
ConditionsYield
With potassium tert-butylate In methanol; tert-butyl alcohol at 50℃; for 1h; Solvent;92.5%
With potassium tert-butylate In tert-butyl alcohol at 50℃; for 1h; Reagent/catalyst; Solvent;89%
With potassium tert-butylate In tert-butyl alcohol at 50℃; for 1h; Solvent; Reagent/catalyst;89%
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 3h;91.8%
Stage #1: (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone; (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 4h;
Stage #2: With water at 20 - 21℃; for 1.83333h;
91.8%
With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 4h; Industry scale;91.8%
p-fluorotoluene
352-32-9

p-fluorotoluene

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(S)-3-p-cresyltetrahydrofuran

(S)-3-p-cresyltetrahydrofuran

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 0 - 10℃; for 1.5h; Inert atmosphere; Large scale;91%
(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

methyl iodide
74-88-4

methyl iodide

(S)-(+)-3-methoxytetrahydrofuran

(S)-(+)-3-methoxytetrahydrofuran

Conditions
ConditionsYield
With sodium hydride In diethyl ether at 25℃; for 24h; Etherification;90%
6-(2,4-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylbenzo[d]oxazole
1618663-21-0

6-(2,4-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylbenzo[d]oxazole

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(S)-6-(2-chloro-4-((tetrahydrofuran-3-yl)oxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylbenzo[d]oxazole
1618663-42-5

(S)-6-(2-chloro-4-((tetrahydrofuran-3-yl)oxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylbenzo[d]oxazole

Conditions
ConditionsYield
With sodium t-butanolate In 1,4-dioxane at 75℃; for 5h;90%
With sodium t-butanolate In 1,4-dioxane at 25℃; for 16h;68%
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