Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Cas:86087-23-2
Min.Order:100 Gram
FOB Price: $10.0
Type:Manufacturers
inquiryThe company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an
Cas:86087-23-2
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:86087-23-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryAssay: 99% up; Stable supply with over 50Mt annually; Appearance:White or off-white powder Storage:room temprature Package:1kg/bag, 25kg/drum Application:Intermediate of Empagliflozin Port:Beijing/Shanghai/Shenzhen/Hangzhou
Cas:86087-23-2
Min.Order:1 Kilogram
FOB Price: $875.0 / 955.0
Type:Trading Company
inquiryUnique advantages for (S)-(+)-3-Hydroxytetrahydrofuran Cas 86087-23-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Transparent yellow to light brown liquid Storage:Cool dr
Cas:86087-23-2
Min.Order:1 Kilogram
FOB Price: $480.0 / 530.0
Type:Trading Company
inquiry(S)-Tetrahydrofuran-3-ol[CAS:86087-23-2] (S)-(+)-3-Hydroxytetrahydrofuran (S)-(+)-Tetrahydro-3-furanol HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, r
Cas:86087-23-2
Min.Order:1 Kilogram
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Type:Other
inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:intermediate Transportation:According to
Cas:86087-23-2
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:86087-23-2
Min.Order:1
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Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:86087-23-2
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr
Cas:86087-23-2
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less tha
Cas:86087-23-2
Min.Order:0 Metric Ton
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Type:Manufacturers
inquiry
Cas:86087-23-2
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:86087-23-2
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FOB Price: $1.0 / 3.0
Type:Trading Company
inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1378.html Product Name (S)-(+)-3-Hydroxytetrahydrofuran CAS No. 86087-23-2
Cas:86087-23-2
Min.Order:1 Gram
FOB Price: $6.0
Type:Lab/Research institutions
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu
Cas:86087-23-2
Min.Order:1 Gram
FOB Price: $0.4 / 0.5
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and
Cas:86087-23-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:86087-23-2
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:86087-23-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:86087-23-2
Min.Order:1 Kilogram
FOB Price: $10.0 / 40.0
Type:Trading Company
inquiryProduct Name S-3-Hydroxytetrahydrofuran CAS NO. 86087-23-2 Molecular formula C4H8O2 Molecular weight 88.10510 Structure
We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:86087-23-2
Min.Order:1 Gram
FOB Price: $3.0
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers
Cas:86087-23-2
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:86087-23-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:86087-23-2
Min.Order:10 Gram
FOB Price: $8.8
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:86087-23-2
Min.Order:1 Kilogram
FOB Price: $500.0 / 600.0
Type:Trading Company
inquiry(S)-(+)-3-Hydroxytetrahydrofuran CAS: 86087-23-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality
Cas:86087-23-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:86087-23-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:86087-23-2
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:As
Cas:86087-23-2
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiry(3S)-4-chloro-1,3-butanediol
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide In methanol; water | 99.8% |
With potassium hydroxide In methanol at 40℃; for 4h; Reagent/catalyst; | 97% |
In anhydrous ethylene glycol dimethyl ether at 110℃; for 5h; Product distribution / selectivity; | 90% |
4-chloro-3-hydroxy-1-butanol
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With hydrogenchloride In water at 50℃; for 4h; Solvent; Reagent/catalyst; | 94.6% |
A
ethyl p-methoxybenzyl sulfide
B
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With aluminium trichloride; ethanethiol In dichloromethane for 5h; Ambient temperature; | A n/a B 93% |
(S)-1,2,4-butanetriol
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid (3a preparation above 7a); | 87% |
toluene-4-sulfonic acid In PEG-400 at 120 - 160℃; under 10 Torr; for 12h; Product distribution / selectivity; | 83% |
strong acid ion exchange resin (Amberlyst 15, H+ form) In 1,4-dioxane at 90 - 120℃; under 760.051 - 5931.67 Torr; Product distribution / selectivity; | 70% |
With toluene-4-sulfonic acid | |
With toluene-4-sulfonic acid In water at 90℃; | 10 g |
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 20℃; for 3h; | 83% |
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen at 40℃; | 81.5% |
(R)-3-Hydroxytetrahydrofuran
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
Stage #1: (R)-3-Hydroxytetrahydrofuran With azodicarboxylic acid bis(2-methoxyethyl) ester; 4-diphenylphosphanobenzoic acid In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: With water; sodium hydroxide In tetrahydrofuran at 20℃; stereospecific reaction; | 64% |
2-(oxiran-2-yl)ethyl 4-methylbenzenesulfonate
A
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With (S,S)-(salen)cobalt(III)(OAc); water In tetrahydrofuran at 0 - 25℃; for 14h; optical yield given as %ee; enantioselective reaction; | A 48% B 47% |
2,3-dihydro-2H-furan
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
2,5-dihydrofuran
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
Multistep reaction; | |
Yield given. Multistep reaction; |
A
(R)-3-Hydroxytetrahydrofuran
B
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol for 16h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
4-chloro-3-hydroxy-1-butanol
A
2,5-dihydrofuran
B
(R)-3-Hydroxytetrahydrofuran
C
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With hydrogenchloride for 2h; Heating; | A 15 % Chromat. B n/a C n/a |
With hydrogenchloride for 2h; Heating; Yields of byproduct given. Title compound not separated from byproducts; | A 15 % Chromat. B n/a C n/a |
3-Hydroxytetrahydrofuran
A
(R)-3-Hydroxytetrahydrofuran
B
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With vinyl acetate; Candida antarctica B lipase on carrier C3 In hexane at 37℃; for 0.0833333h; Title compound not separated from byproducts; |
(+/-)-tetrahydrofuran-3-yl acetate
A
(R)-3-Hydroxytetrahydrofuran
B
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With sodium phosphate buffer; esterase B from Candida antarctica In water at 37℃; for 1h; pH=7.3; Product distribution; |
(2S)-2-tert-Butoxy-1,4-butanediol
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid at 18 - 77℃; under 12.5 - 15 Torr; |
3-Hydroxytetrahydrofuran
vinyl acetate
A
(R)-3-Hydroxytetrahydrofuran
B
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With EL-14 lipase In hexane at 4℃; for 16h; Enzymatic reaction; optical yield given as %ee; enantioselective reaction; |
but-3-enyl 4-methylbenzenesulfonate
A
(R)-3-Hydroxytetrahydrofuran
B
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With potassium osmate(VI) dihydrate; methanesulfonamide; water; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III) In tert-butyl alcohol at 0℃; for 6h; Sharpless asymmetric dihydroxylation; optical yield given as %ee; |
(+/-)-tetrahydrofuran-3-yl acetate
A
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With crude extract of Escherichia coli DH5α cells containing Bacillus stearothermophilus esterase, D31T/L93F mutant In aq. phosphate buffer at 37℃; for 42h; pH=7.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction; |
tetrahydrofuran-3-one
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With nicotinamide adenine dinucleotide In aq. phosphate buffer; acetonitrile at 30℃; for 4h; pH=7.4; Kinetics; Reagent/catalyst; Enzymatic reaction; enantioselective reaction; | n/a |
With alcohol dehydrogenase fromThermoanaerobacter brockii, A85V/I86L/L294Q mutant; NADP; lysozyme; DNase I In isopropyl alcohol at 30℃; for 16h; Enzymatic reaction; stereoselective reaction; | n/a |
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With sodium hydroxide In dimethyl sulfoxide at 170 - 190℃; Reagent/catalyst; Inert atmosphere; |
tetrahydrofuran-3-one
A
(R)-3-Hydroxytetrahydrofuran
B
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With alcohol dehydrogenase fromThermoanaerobacter brockii, A85V/I86L/L294H mutant; NADP; lysozyme; DNase I In isopropyl alcohol at 30℃; for 16h; Enzymatic reaction; stereoselective reaction; | A n/a B n/a |
With alcohol dehydrogenase fromThermoanaerobacter brockii, L294C mutant; NADP; lysozyme; DNase I In isopropyl alcohol at 30℃; for 16h; Enzymatic reaction; stereoselective reaction; | A n/a B n/a |
di(succinimido) carbonate
(S)-3-hydroxytetyrahydrofurane
1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 20℃; for 18h; | 100% |
With triethylamine In acetonitrile at 20℃; for 18h; | 100% |
With triethylamine In acetonitrile at 20℃; for 21.5h; | 94% |
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With dmap In acetonitrile at 20℃; | 100% |
(S)-3-hydroxytetyrahydrofurane
Carbonic acid (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester 4-nitro-phenyl ester
Carbonic acid (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester (S)-(tetrahydro-furan-3-yl) ester
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane for 48h; Heating; | 100% |
3-hydroxy-5-(4-methanesulfonylphenoxy)benzoic acid methyl ester
(S)-3-hydroxytetyrahydrofurane
C19H20O7S
Conditions | Yield |
---|---|
With 4,4-(dimethyl-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)-triphenyl phosphonium In dichloromethane; toluene at 20℃; for 15h; | 100% |
(S)-3-hydroxytetyrahydrofurane
p-toluenesulfonyl chloride
toluene-4-sulfonic acid (S)-(tetrahydrofuran-3-yl)ester
Conditions | Yield |
---|---|
With 1H-imidazole; dmap In dichloromethane at 20℃; for 16h; | 100% |
With pyridine | 100% |
With trimethylamine hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 4h; | 99% |
(3-fluoro-2-hydroxy-5-nitro-benzyl)-methyl-carbamic acid tert-butyl ester
(S)-3-hydroxytetyrahydrofurane
(R)-tert-butyl 3-fluoro-5-nitro-2-((tetrahydrofuran-3-yl)oxy)benzyl(methyl)carbamate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 16.5h; | 100% |
trifluoromethylsulfonic anhydride
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
Stage #1: trifluoromethylsulfonic anhydride With N-ethyl-N,N-diisopropylamine In dichloromethane at -78℃; for 0.0833333h; Inert atmosphere; Stage #2: (S)-3-hydroxytetyrahydrofurane In dichloromethane at -78 - 20℃; for 3h; Inert atmosphere; | 100% |
With pyridine In dichloromethane at -10℃; for 0.5h; |
(S)-3-hydroxytetyrahydrofurane
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Conditions | Yield |
---|---|
Stage #1: (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h; Stage #2: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine In tetrahydrofuran at 20℃; for 3h; | 99.5% |
Stage #1: (S)-3-hydroxytetyrahydrofurane With sodium hydride In tetrahydrofuran; mineral oil for 0.75h; Cooling with ice; Stage #2: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine In tetrahydrofuran at 20℃; for 5h; | 99.5% |
Stage #1: (S)-3-hydroxytetyrahydrofurane With sodium hydride In tetrahydrofuran; mineral oil for 0.75h; Cooling with ice; Stage #2: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine In tetrahydrofuran; mineral oil at 20℃; for 5h; | 99.5% |
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
Stage #1: (S)-3-hydroxytetyrahydrofurane With sodium hydride In tetrahydrofuran; mineral oil for 0.75h; Cooling with ice; Stage #2: 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-fluoroquinazoline In tetrahydrofuran; mineral oil at 20℃; for 5h; | 99.5% |
1-(2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
Stage #1: (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere; Stage #2: 1-(2-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one In tetrahydrofuran at 0 - 20℃; for 2.16667h; | 98% |
4-((3-chloro-4-fluorophenyl)amino)-6-nitro-7-chloroquinazoline
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
Stage #1: (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In N,N-dimethyl-formamide at 0℃; for 2h; Stage #2: 7-chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine With sodium benzenesulfonate In N,N-dimethyl-formamide at 30 - 90℃; for 6h; | 97.8% |
With potassium tert-butylate; sodium methansulfinate In N,N-dimethyl-formamide at 80℃; for 3h; Reagent/catalyst; Solvent; Temperature; | 93% |
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
Stage #1: (S)-3-hydroxytetyrahydrofurane With sodium hydride In N,N-dimethyl-formamide for 0.5h; Stage #2: 2-(chloromethyl)-4-hydroxy-5,8-dihydropyridine[3,4-d]pyrimidine-7(6H)-carboxylic acid tert-butyl ester In N,N-dimethyl-formamide at 20℃; for 1h; | 97% |
(S)-3-hydroxytetyrahydrofurane
methanesulfonyl chloride
[(3S)-tetrahydrofuran-3-yl] methanesulfonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 1h; Cooling with ice; | 96% |
With triethylamine In dichloromethane at 20℃; Cooling with ice; | 83% |
With triethylamine In dichloromethane at 0℃; for 4h; | 80% |
methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate
(S)-3-hydroxytetyrahydrofurane
methyl 6-{2,6-difluoro-4-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-5-fluoropyridine-2-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; | 96% |
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 2h; | 96% |
(S)-3-hydroxytetyrahydrofurane
toluene-4-sulfonic acid
toluene-4-sulfonic acid (S)-(tetrahydrofuran-3-yl)ester
Conditions | Yield |
---|---|
Stage #1: (S)-3-hydroxytetyrahydrofurane With dmap; triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: toluene-4-sulfonic acid at 20 - 50℃; for 1.66667h; | 96% |
4-hydroxybenzyl chloride
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
Stage #1: 4-hydroxybenzyl chloride In dichloromethane at -5 - 0℃; for 3h; Stage #2: (S)-3-hydroxytetyrahydrofurane With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 4.5h; Reagent/catalyst; Reflux; | 95.3% |
(S)-3-hydroxytetyrahydrofurane
4-Fluoronitrobenzene
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20 - 25℃; for 1h; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; | 94.3% |
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol at 0 - 10℃; for 1.5h; Inert atmosphere; Large scale; | 94% |
With potassium tert-butylate In tetrahydrofuran at 0 - 10℃; for 1h; Inert atmosphere; Large scale; | 94% |
(2-chloro-5-bromophenyl)(4-fluorophenyl)methanone
(S)-3-hydroxytetyrahydrofurane
(S)-(5-bromo-2-chlorophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃; | 93% |
With potassium tert-butylate In tetrahydrofuran at 7 - 10℃; for 0.5h; | 87% |
With potassium tert-butylate In tetrahydrofuran at 0 - 10℃; for 2h; | 85.3% |
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu Displacement; Inert atmosphere; | 93% |
(S)-3-hydroxytetyrahydrofurane
1-bromo-3-(bromomethyl)-2-fluorobenzene
Conditions | Yield |
---|---|
Stage #1: (S)-3-hydroxytetyrahydrofurane With sodium hydride In N,N-dimethyl-formamide for 1h; Inert atmosphere; Stage #2: 1-bromo-3-(bromomethyl)-2-fluorobenzene In N,N-dimethyl-formamide for 17h; Inert atmosphere; | 92.51% |
(S)-3-hydroxytetyrahydrofurane
Conditions | Yield |
---|---|
With potassium tert-butylate In methanol; tert-butyl alcohol at 50℃; for 1h; Solvent; | 92.5% |
With potassium tert-butylate In tert-butyl alcohol at 50℃; for 1h; Reagent/catalyst; Solvent; | 89% |
With potassium tert-butylate In tert-butyl alcohol at 50℃; for 1h; Solvent; Reagent/catalyst; | 89% |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
(S)-3-hydroxytetyrahydrofurane
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 3h; | 91.8% |
Stage #1: (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone; (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 4h; Stage #2: With water at 20 - 21℃; for 1.83333h; | 91.8% |
With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 4h; Industry scale; | 91.8% |
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 0 - 10℃; for 1.5h; Inert atmosphere; Large scale; | 91% |
Conditions | Yield |
---|---|
With sodium hydride In diethyl ether at 25℃; for 24h; Etherification; | 90% |
6-(2,4-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylbenzo[d]oxazole
(S)-3-hydroxytetyrahydrofurane
(S)-6-(2-chloro-4-((tetrahydrofuran-3-yl)oxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylbenzo[d]oxazole
Conditions | Yield |
---|---|
With sodium t-butanolate In 1,4-dioxane at 75℃; for 5h; | 90% |
With sodium t-butanolate In 1,4-dioxane at 25℃; for 16h; | 68% |
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