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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

High quality/Best price/Key global supplier/In stock/Express shipment/ EG3/CAS No.915095-87-3

Cas:915095-87-3

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone CAS NO.915095-87-3

Cas:915095-87-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone CAS No.:915095-87-3 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)methanone

Cas:915095-87-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1624.html Product Name (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone Synonyms: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone;Methanone, (2-chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-fura

915095-87-3 (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:1 Kilogram

FOB Price: $8900.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Product Name (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl] Synonyms (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl];EnglenetImpurity18;,(2-chloro-5-iodopChemicalbookhenyl)[4-[[(3S)-tetrahy

Raw Material Factory Supply High Quality Empagliflozin Intermediates CAS#915095-87-3

Cas:915095-87-3

Min.Order:1 Kilogram

FOB Price: $15.0 / 40.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 915095-87-3 with best quality

Cas:915095-87-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone CAS NO.915095-87-3

Cas:915095-87-3

Min.Order:10 Kilogram

FOB Price: $180.0 / 200.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone 915095-87-3

Cas:915095-87-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone CAS:915095-87-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical i

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone CAS:915095-87-3

Cas:915095-87-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

(2-CHLORO-5-IODOPHENYL)[4-[[(3S)-TETRAHYDRO-3-FURANYL)OXY]PHENYL]METHANONE

Cas:915095-87-3

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone Synonyms: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone;Methanone, (2-chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]ph

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone supplier best quality

Cas:915095-87-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:As

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone 915095-87-3

Cas:915095-87-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(2-CHLORO-5-IODOPHENYL)[4-[[(3S)-TETRAHYDRO-3-FURANYL]OXY]PHENYL]MET HANONE

Cas:915095-87-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(S)-(2-chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone

Cas:915095-87-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

ProName: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetra... CasNo: 915095-87-3 Molecular Formula: C17H14ClIO3 Appearance: detailed in specifications Application: An important raw material and intermed... DeliveryTime: prompt PackAge: according to the

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone CAS NO.915095-87-3

Cas:915095-87-3

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone CAS NO.915095-87-3

Cas:915095-87-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (2-chloro-5-iodophenyl)[4-[[(3S)-Tetrahydro-3-Furanyl]oxy]phenyl]methanone CAS No.: 915095-87-3 Molecule Formula:C17H14ClIO3 Molecule Weight:428.65 Purity: 97.0% Package: 25kg/drum Description:Light yellow powder Manufacture Stan

Lower Price (2-chloro-5-iodophenyl)[4-[[(3S)-Tetrahydro-3-Furanyl]oxy]phenyl]methanone on stock

Cas:915095-87-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Cas:915095-87-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 3h;91.8%
Stage #1: (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone; (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 4h;
Stage #2: With water at 20 - 21℃; for 1.83333h;
91.8%
With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 4h; Industry scale;91.8%
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone
1459754-40-5

(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone

(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
219823-47-9

(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 50 - 55℃;87%
2-chloro-5-iodobenzoic acid
19094-56-5

2-chloro-5-iodobenzoic acid

(S)-3-phenoxytetrahydrofuran

(S)-3-phenoxytetrahydrofuran

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
Stage #1: 2-chloro-5-iodobenzoic acid With oxalyl chloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 4h; Friedel-Crafts Acylation;
Stage #2: (S)-3-phenoxytetrahydrofuran With aluminum (III) chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 3h;
81%
fluorobenzene
462-06-6

fluorobenzene

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 °C
2: potassium tert-butylate / tetrahydrofuran / 3 h / 16 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 °C
1.2: 6 h / 20 - 30 °C
2.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C
2.2: 1.83 h / 20 - 21 °C
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride; aluminum (III) chloride / N,N-dimethyl-formamide / 25 - 45 °C / Industry scale
2: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C / Industry scale
View Scheme
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h
1.2: 1 h / 0 - 5 °C
2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 16 - 25 °C
View Scheme
2-chloro-5-iodobenzoic acid
19094-56-5

2-chloro-5-iodobenzoic acid

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 °C
2: potassium tert-butylate / tetrahydrofuran / 3 h / 16 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 °C
1.2: 6 h / 20 - 30 °C
2.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C
2.2: 1.83 h / 20 - 21 °C
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride; aluminum (III) chloride / N,N-dimethyl-formamide / 25 - 45 °C / Industry scale
2: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C / Industry scale
View Scheme
2-chloro-5-iodobenzoylchloride
281652-58-2

2-chloro-5-iodobenzoylchloride

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aluminum (III) chloride / 1 h / 0 - 25 °C
2: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
View Scheme
Multi-step reaction with 2 steps
1: aluminum (III) chloride / 25 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C
View Scheme
Multi-step reaction with 2 steps
1: aluminum (III) chloride / dichloromethane / 6 h / -5 °C
2: potassium tert-butylate / tetrahydrofuran / 20 °C
View Scheme
phenol
108-95-2

phenol

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: polyposphoric acid / 50 - 85 °C
2: potassium iodide; potassium carbonate / acetonitrile / 50 - 55 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
With aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane In toluene at 0 - 23℃; for 2.5h;93%
With aluminum (III) chloride; sodium tetrahydroborate In tetrahydrofuran for 5h; Reflux;90%
With potassium borohydride; trifluoroacetic acid In tetrahydrofuran at 0 - 20℃; for 0.5h;85%
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C17H16Cl2MgO2

C17H16Cl2MgO2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,1,3,3-Tetramethyldisiloxane / aluminum (III) chloride / toluene / 2.5 h / 18 - 26 °C
2: TurboGrignard / tetrahydrofuran / 1.83 h / -15 - 21 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

empagliflozin
864070-44-0

empagliflozin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C
2.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.83 h / -21 - -15 °C
2.2: 2.92 h / -25 - -13 °C
View Scheme
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C / Industry scale
1.2: 20 - 51 °C / Industry scale
2.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.83 h / -21 - -15 °C / Industry scale
2.2: 2.92 h / -25 - -18 °C / Industry scale
2.3: -13 - 19 °C / Industry scale
View Scheme
Multi-step reaction with 5 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4: hydrogenchloride / isopropyl alcohol; methanol
5: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 20 - 25 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / ethanol / 20 - 25 °C
2: methanesulfonic acid / 20 - 30 °C
3: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere
4: methanesulfonic acid / 20 - 25 °C
5: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / -40 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / ethanol / 20 - 25 °C
2: triethylamine / dichloromethane / 0 - 35 °C
3: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere
4: methanesulfonic acid / 0 - 35 °C
5: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / -40 - 20 °C / Inert atmosphere
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C35H59ClO8Si4

C35H59ClO8Si4

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C24H29ClO8

C24H29ClO8

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
1279691-36-9

(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4: hydrogenchloride / isopropyl alcohol; methanol
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate

(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4: hydrogenchloride / isopropyl alcohol; methanol
5: triethylamine; dmap / tetrahydrofuran
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

(2S,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

(2S,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4: hydrogenchloride / isopropyl alcohol; methanol
5: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

(2S,3R,4S,5R,6R)-3,4,5-tris(allyloxy)-6-((allyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

(2S,3R,4S,5R,6R)-3,4,5-tris(allyloxy)-6-((allyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4: hydrogenchloride / isopropyl alcohol; methanol
5: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

A

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityl triacetate

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityl triacetate

B

C31H35ClO11

C31H35ClO11

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3.1: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4.1: hydrogenchloride / isopropyl alcohol; methanol
5.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
6.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
6.2: 90 °C
View Scheme
Multi-step reaction with 6 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4: hydrogenchloride / isopropyl alcohol; methanol
5: triethylamine; dmap / tetrahydrofuran
6: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

A

2,3,4,6-tetra-O-benzyl-1-deoxy-1-((S)-(4-chloro-3-(4-(tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-β-D-glucopyranose

2,3,4,6-tetra-O-benzyl-1-deoxy-1-((S)-(4-chloro-3-(4-(tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-β-D-glucopyranose

B

C51H51ClO7

C51H51ClO7

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4: hydrogenchloride / isopropyl alcohol; methanol
5: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
6: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

A

1-chloro-4-(2,3,4,6-tetra-O-allyl-D-glucopyranos-1-yl)-2-(4-(S)-tetrahydrofuran-3-yloxy-benzyl)-benzene

1-chloro-4-(2,3,4,6-tetra-O-allyl-D-glucopyranos-1-yl)-2-(4-(S)-tetrahydrofuran-3-yloxy-benzyl)-benzene

B

C35H43ClO7

C35H43ClO7

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4: hydrogenchloride / isopropyl alcohol; methanol
5: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
6: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C23H27ClO7

C23H27ClO7

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4: hydrogenchloride / isopropyl alcohol; methanol
5: boron trifluoride diethyl etherate / water
6: triethylsilane
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C23H27ClO8

C23H27ClO8

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4: hydrogenchloride / isopropyl alcohol; methanol
5: boron trifluoride diethyl etherate / water
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

(2R,3R,4R,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

(2R,3R,4R,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
3.1: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
4.1: hydrogenchloride / isopropyl alcohol; methanol
5.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
6.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
6.2: 90 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran / 5 h / Reflux
2.1: n-butyllithium / toluene / 3 h / -20 °C / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
3.1: toluene / 6 h / 110 °C / Inert atmosphere
4.1: sodium methylate; methanol / 5 h / Reflux
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

(1R,2S,3R,4R,5S)-1-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol

(1R,2S,3R,4R,5S)-1-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C17H16ClIO3

C17H16ClIO3

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 20 - 25℃;98 g
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C20H24ClIO3Si

C20H24ClIO3Si

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / ethanol / 20 - 25 °C
2: triethylamine / dichloromethane / 0 - 35 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C18H18ClIO3

C18H18ClIO3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / ethanol / 20 - 25 °C
2: methanesulfonic acid / 20 - 30 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C38H67ClO9Si5

C38H67ClO9Si5

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / ethanol / 20 - 25 °C
2: triethylamine / dichloromethane / 0 - 35 °C
3: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C25H31ClO9

C25H31ClO9

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / ethanol / 20 - 25 °C
2: methanesulfonic acid / 20 - 30 °C
3: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere
4: methanesulfonic acid / 20 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / ethanol / 20 - 25 °C
2: triethylamine / dichloromethane / 0 - 35 °C
3: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere
4: methanesulfonic acid / 0 - 35 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C36H61ClO9Si4

C36H61ClO9Si4

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / ethanol / 20 - 25 °C
2: methanesulfonic acid / 20 - 30 °C
3: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C24H29ClO9

C24H29ClO9

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / ethanol / 20 - 25 °C
2: methanesulfonic acid / 20 - 30 °C
3: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere
4: hydrogenchloride; water / methanol / 20 - 25 °C
View Scheme
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

C43H59ClO11

C43H59ClO11

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran / 5 h / Reflux
2.1: n-butyllithium / toluene / 3 h / -20 °C / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
3.1: toluene / 6 h / 110 °C / Inert atmosphere
View Scheme

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