Products

Refine

Country

Business Type

Certificate

Display

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Buy Quality Top Purity 915095-94-2 Fast Delivery

Cas:915095-94-2

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High purity 99% factory price Empagliflozin intermediate

Cas:915095-94-2

Min.Order:1 Kilogram

FOB Price: $25.0 / 500.0

Type:Trading Company

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan supplier in China

Cas:915095-94-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min -----------------------------------------------------------------------------------------------

High purity (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan CAS:915095-94-2

Cas:915095-94-2

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Empagliflozin intermediate manufacturer/supplier

Cas:915095-94-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermediate Transpo

Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:white pow

3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

Cas:915095-94-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(3S)-3-[4-(2-Chloro-5-iodobenzyl)-phenoxy]-tetrahydrofuran

Cas:915095-94-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1625.html Product Name (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Competitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

(3S) -3-[4-[ (2-Chloro-5-iodophenyl) Methyl]Phenoxy]Tetrahydro-Furan 915095-94-2

Cas:915095-94-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 915095-94-2 with best quality

Cas:915095-94-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan Synonyms: Empagliflozin intermediate CAS: 915095-94-2 MF: C17H16ClIO2 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Appli

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

Empagliflozin Intermediate 915095-94-2 API Manufacturer

Cas:915095-94-2

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hangzhou Think Chemical Co. Ltd

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan CAS NO.:915095-94-2 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. W

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2

Cas:915095-94-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran WITH CAS:915095-94-2

Cas:915095-94-2

Min.Order:1 Kilogram

FOB Price: $720.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan CAS: 915095-94-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermed

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan CAS: 915095-94-2

Cas:915095-94-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:1 Kilogram

FOB Price: $12.0 / 16.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

Cas:915095-94-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
With aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane In toluene at 0 - 23℃; for 2.5h;93%
With aluminum (III) chloride; sodium tetrahydroborate In tetrahydrofuran for 5h; Reflux;90%
With potassium borohydride; trifluoroacetic acid In tetrahydrofuran at 0 - 20℃; for 0.5h;85%
4-(2-chloro-5-iodobenzyl)phenol
1459754-32-5

4-(2-chloro-5-iodobenzyl)phenol

toluene-4-sulfonic acid (S)-(tetrahydrofuran-3-yl)ester
112052-11-6

toluene-4-sulfonic acid (S)-(tetrahydrofuran-3-yl)ester

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; potassium iodide In acetonitrile at 50 - 55℃; Large scale;90.1%
(S)-3-(4-(5-iodo-2-aminobenzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(5-iodo-2-aminobenzyl)phenoxy)tetrahydrofuran

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Stage #1: (S)-3-(4-(5-iodo-2-aminobenzyl)phenoxy)tetrahydrofuran With hydrogenchloride; sodium nitrite In water at -10 - 0℃; for 2.5h;
Stage #2: With hydrogenchloride; copper(l) chloride In water at 20 - 80℃; for 3h;
75.2%
fluorobenzene
462-06-6

fluorobenzene

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 °C
2: potassium tert-butylate / tetrahydrofuran / 3 h / 16 - 25 °C
3: 1,1,3,3-Tetramethyldisiloxane / aluminum (III) chloride / toluene / 2.5 h / 18 - 26 °C
View Scheme
Multi-step reaction with 3 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 °C
1.2: 6 h / 20 - 30 °C
2.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C
2.2: 1.83 h / 20 - 21 °C
3.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C
View Scheme
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; aluminum (III) chloride / N,N-dimethyl-formamide / 25 - 45 °C / Industry scale
2.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C / Industry scale
3.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C / Industry scale
3.2: 20 - 51 °C / Industry scale
View Scheme
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h
1.2: 1 h / 0 - 5 °C
2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 16 - 25 °C
3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 5 - 10 °C
View Scheme
2-chloro-5-iodobenzoic acid
19094-56-5

2-chloro-5-iodobenzoic acid

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 °C
2: potassium tert-butylate / tetrahydrofuran / 3 h / 16 - 25 °C
3: 1,1,3,3-Tetramethyldisiloxane / aluminum (III) chloride / toluene / 2.5 h / 18 - 26 °C
View Scheme
Multi-step reaction with 3 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 °C
1.2: 6 h / 20 - 30 °C
2.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C
2.2: 1.83 h / 20 - 21 °C
3.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C
View Scheme
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; aluminum (III) chloride / N,N-dimethyl-formamide / 25 - 45 °C / Industry scale
2.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C / Industry scale
3.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C / Industry scale
3.2: 20 - 51 °C / Industry scale
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 3 h / 16 - 25 °C
2: 1,1,3,3-Tetramethyldisiloxane / aluminum (III) chloride / toluene / 2.5 h / 18 - 26 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C
1.2: 1.83 h / 20 - 21 °C
2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C / Industry scale
2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C / Industry scale
2.2: 20 - 51 °C / Industry scale
View Scheme
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 20 °C
2: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran / 5 h / Reflux
View Scheme
2-chloro-5-iodobenzoylchloride
281652-58-2

2-chloro-5-iodobenzoylchloride

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum (III) chloride / 1 h / 0 - 25 °C
2: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
3: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
View Scheme
Multi-step reaction with 3 steps
1: aluminum (III) chloride / dichloromethane / 6 h / -5 °C
2: potassium tert-butylate / tetrahydrofuran / 20 °C
3: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran / 5 h / Reflux
View Scheme
phenol
108-95-2

phenol

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: polyposphoric acid / 50 - 85 °C
2: potassium iodide; potassium carbonate / acetonitrile / 50 - 55 °C
3: potassium borohydride; trifluoroacetic acid / tetrahydrofuran / 0.5 h / 0 - 20 °C
View Scheme
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone
1459754-40-5

(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium iodide; potassium carbonate / acetonitrile / 50 - 55 °C
2: potassium borohydride; trifluoroacetic acid / tetrahydrofuran / 0.5 h / 0 - 20 °C
View Scheme
4-hydroxybenzyl chloride
35421-08-0

4-hydroxybenzyl chloride

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfonyl chloride / dichloromethane / 3 h / -5 - 0 °C
1.2: 4.5 h / Reflux
2.1: zinc(II) chloride / ethyl acetate / 6 h / Reflux
3.1: hydrogenchloride; sodium nitrite / water / 2.5 h / -10 - 0 °C
3.2: 3 h / 20 - 80 °C
View Scheme
2-chloro-5-iodobenzoic acid
19094-56-5

2-chloro-5-iodobenzoic acid

(S)-3-phenoxytetrahydrofuran

(S)-3-phenoxytetrahydrofuran

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: oxalyl chloride / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C
1.2: 3 h / 0 - 20 °C
2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0 - 20 °C
View Scheme
4-iodo-2-(4-methoxybenzyl)aniline

4-iodo-2-(4-methoxybenzyl)aniline

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; sodium nitrite / water / 2.5 h / -10 - 0 °C / Large scale
1.2: 1.5 h / 70 - 80 °C / Large scale
2.1: boron tribromide / dichloromethane / 1.5 h / -15 °C / Inert atmosphere; Large scale
3.1: N-ethyl-N,N-diisopropylamine; potassium iodide / acetonitrile / 50 - 55 °C / Large scale
View Scheme
p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: zinc(II) chloride / ethyl acetate / 7 h / Reflux; Large scale
2.1: hydrogenchloride; sodium nitrite / water / 2.5 h / -10 - 0 °C / Large scale
2.2: 1.5 h / 70 - 80 °C / Large scale
3.1: boron tribromide / dichloromethane / 1.5 h / -15 °C / Inert atmosphere; Large scale
4.1: N-ethyl-N,N-diisopropylamine; potassium iodide / acetonitrile / 50 - 55 °C / Large scale
View Scheme
p-aminoiodobenzene
540-37-4

p-aminoiodobenzene

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: zinc(II) chloride / ethyl acetate / 7 h / Reflux; Large scale
2.1: hydrogenchloride; sodium nitrite / water / 2.5 h / -10 - 0 °C / Large scale
2.2: 1.5 h / 70 - 80 °C / Large scale
3.1: boron tribromide / dichloromethane / 1.5 h / -15 °C / Inert atmosphere; Large scale
4.1: N-ethyl-N,N-diisopropylamine; potassium iodide / acetonitrile / 50 - 55 °C / Large scale
View Scheme
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
32469-28-6, 55515-28-1, 55515-29-2, 32384-65-9

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucopyranoside
1417573-74-0

1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucopyranoside

Conditions
ConditionsYield
Stage #1: (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran With isopropylmagnesium chloride; lithium chloride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;
Stage #2: (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one In tetrahydrofuran at -25℃; for 1h; Inert atmosphere;
96%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

C8CuF9
140468-35-5

C8CuF9

C25H16ClF9O2

C25H16ClF9O2

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 70℃; for 33h;96%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

pentafluoroethylcopper(I)
60007-39-8

pentafluoroethylcopper(I)

(S)-3-(4-(2-chloro-5-(perfluoroethyl)benzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(2-chloro-5-(perfluoroethyl)benzyl)phenoxy)tetrahydrofuran

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 36h; Inert atmosphere; Sealed tube; Glovebox;93%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

1-chloro-4-(2,3,4,6-tetra-O-acetyl-D-glucopyranos-1-yl)-2-(4-(R)-tetrahydrofuran-3-yloxy-benzyl)-benzene
915095-98-6

1-chloro-4-(2,3,4,6-tetra-O-acetyl-D-glucopyranos-1-yl)-2-(4-(R)-tetrahydrofuran-3-yloxy-benzyl)-benzene

Conditions
ConditionsYield
With bis(acetylacetonate)nickel(II); magnesium chloride; 4,4',4-tri-tert-butyl-2,2':6',2-terpyridine; zinc In tetrahydrofuran at 20℃; Schlenk technique; Inert atmosphere; Cooling with ice;90%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

(1,5-anhydro-2-deoxy-4,6-O-bis(tert-butylsilylidene)-3-O-triisopropylsilyl-D-arabino-hex-1-enitol)boronic acid pinacol ester
842132-50-7

(1,5-anhydro-2-deoxy-4,6-O-bis(tert-butylsilylidene)-3-O-triisopropylsilyl-D-arabino-hex-1-enitol)boronic acid pinacol ester

C40H61ClO6Si2

C40H61ClO6Si2

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; water for 8h; Reflux; Inert atmosphere; Large scale;89%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
32469-28-6, 55515-28-1, 55515-29-2, 32384-65-9

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

(2S,3R,4S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
1279691-35-8

(2S,3R,4S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

Conditions
ConditionsYield
Stage #1: (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran; (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one With TurboGrignard In tetrahydrofuran at -30 - -20℃; for 1h; Inert atmosphere;
Stage #2: With citric acid In tetrahydrofuran; water for 0.5h; Inert atmosphere;
82.2%
Stage #1: (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran With isopropylmagnesium chloride; lithium chloride In acetonitrile at -20 - -15℃; for 1h; Large scale;
Stage #2: (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one In acetonitrile at -10 - 0℃; for 8h; Solvent; Large scale;
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

C18H42O6Si4

C18H42O6Si4

C23H27ClO8

C23H27ClO8

Conditions
ConditionsYield
Stage #1: (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran With n-butyllithium In tetrahydrofuran; hexane at -60 - -50℃; for 0.833333h; Inert atmosphere;
Stage #2: C18H42O6Si4 In tetrahydrofuran; hexane at -50℃; Inert atmosphere;
Stage #3: With hydrogenchloride In isopropyl alcohol at 0 - 20℃;
80%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

trans-4-Octene
14850-23-8

trans-4-Octene

(S)-3-(4-(2-chloro-5-octylbenzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(2-chloro-5-octylbenzyl)phenoxy)tetrahydrofuran

Conditions
ConditionsYield
With nickel(II) bromide dimethoxyethane; potassium fluoride; Triethoxysilane; 2-(6-methylpyridin-2-yl)-4,5-dihydrooxazole In N,N-dimethyl-formamide for 24h; Inert atmosphere; Sealed tube; regioselective reaction;78%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

C18H42O6Si4

C18H42O6Si4

(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
1279691-36-9

(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane; toluene at -78 - -65℃; for 2h; Inert atmosphere;77.6%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

C30H66O6Si4

C30H66O6Si4

C25H31ClO8

C25H31ClO8

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane; toluene at -78 - -65℃; for 2h; Inert atmosphere;76.9%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
32469-28-6, 55515-28-1, 55515-29-2, 32384-65-9

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

empagliflozin
864070-44-0

empagliflozin

Conditions
ConditionsYield
Stage #1: (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran With isopropylmagnesium chloride; lithium chloride In tetrahydrofuran at -21 - -15℃; for 1.83333h;
Stage #2: (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one In dichloromethane; acetonitrile at -25 - -13℃; for 2.91667h;
73%
Stage #1: (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran With isopropylmagnesium chloride; lithium chloride In tetrahydrofuran at -21 - -15℃; for 1.83333h; Industry scale;
Stage #2: (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one In tetrahydrofuran at -25 - -18℃; for 2.91667h; Industry scale;
Stage #3: With citric acid In water at -13 - 19℃; Product distribution / selectivity; Industry scale;
73%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

C41H34O12S

C41H34O12S

C51H43ClO11

C51H43ClO11

Conditions
ConditionsYield
Stage #1: (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran With TurboGrignard In tetrahydrofuran at -10 - 0℃; Cooling with ice; Inert atmosphere;
Stage #2: C41H34O12S With 2,6-bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine In tetrahydrofuran at 40 - 50℃; Inert atmosphere;
73%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

2-(but-3-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(but-3-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(1-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)butyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(1-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)butyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
With potassium fluoride; 6,6'-dimethyl-2,2'-bipyridine; nickel(II) bromide 2-methoxyethyl ether complex; Triethoxysilane; potassium iodide In N,N-dimethyl acetamide; acetonitrile at 30℃; for 18h; Sealed tube; regioselective reaction;67%
methanesulfonic acid
75-75-2

methanesulfonic acid

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
32469-28-6, 55515-28-1, 55515-29-2, 32384-65-9

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

C24H29ClO8

C24H29ClO8

Conditions
ConditionsYield
Stage #1: (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran With n-butyllithium In tetrahydrofuran; hexane; toluene at -72 - -60℃; for 0.5h; Inert atmosphere;
Stage #2: (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one In tetrahydrofuran; hexane; toluene at -72℃; for 2h; Inert atmosphere;
Stage #3: methanesulfonic acid In tetrahydrofuran; methanol; hexane; toluene at 20℃;
60.1%
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

trifluorormethanesulfonic acid
1493-13-6

trifluorormethanesulfonic acid

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;30%

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

C35H59ClO7Si4

C35H59ClO7Si4

Conditions
ConditionsYield
Stage #1: (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran With isopropylmagnesium chloride; lithium chloride In tetrahydrofuran at -23 - -22℃; for 0.333333h;
Stage #2: (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one In tetrahydrofuran at -20℃; for 2h;
Stage #3: With ammonium chloride In tetrahydrofuran; water Product distribution / selectivity;
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

C17H16Cl2MgO2

C17H16Cl2MgO2

Conditions
ConditionsYield
With TurboGrignard In tetrahydrofuran at -15 - 21℃; for 1.83333h; Product distribution / selectivity;
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
1279691-36-9

(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
2: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
3: hydrogenchloride / isopropyl alcohol; methanol
View Scheme
Multi-step reaction with 2 steps
1: lithium chloride; isopropylmagnesium chloride / tetrahydrofuran / -30 - -20 °C / Inert atmosphere; Large scale
2: hydrogenchloride / methanol; water / 4 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1.1: TurboGrignard / tetrahydrofuran / 1 h / -30 - -20 °C / Inert atmosphere
1.2: 0.5 h / Inert atmosphere
2.1: hydrogenchloride / water / 1 h / 20 - 30 °C
View Scheme
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

empagliflozin
864070-44-0

empagliflozin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
2: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
3: hydrogenchloride / isopropyl alcohol; methanol
4: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1: lithium chloride; isopropylmagnesium chloride / tetrahydrofuran / -30 - -20 °C / Inert atmosphere; Large scale
2: hydrogenchloride / methanol; water / 4 h / 20 °C / Large scale
3: aluminum (III) chloride; triethylsilane / acetonitrile; dichloromethane
View Scheme
Multi-step reaction with 3 steps
1.1: TurboGrignard / tetrahydrofuran / 1 h / -30 - -20 °C / Inert atmosphere
1.2: 0.5 h / Inert atmosphere
2.1: hydrogenchloride / water / 1 h / 20 - 30 °C
3.1: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile
View Scheme
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate

(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
2: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
3: hydrogenchloride / isopropyl alcohol; methanol
4: triethylamine; dmap / tetrahydrofuran
View Scheme
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

(2S,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

(2S,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
2: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
3: hydrogenchloride / isopropyl alcohol; methanol
4: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
View Scheme
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

(2S,3R,4S,5R,6R)-3,4,5-tris(allyloxy)-6-((allyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

(2S,3R,4S,5R,6R)-3,4,5-tris(allyloxy)-6-((allyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
2: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
3: hydrogenchloride / isopropyl alcohol; methanol
4: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
View Scheme
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

A

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityl triacetate

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityl triacetate

B

C31H35ClO11

C31H35ClO11

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
2.1: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
3.1: hydrogenchloride / isopropyl alcohol; methanol
4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
5.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
5.2: 90 °C
View Scheme
Multi-step reaction with 5 steps
1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
2: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
3: hydrogenchloride / isopropyl alcohol; methanol
4: triethylamine; dmap / tetrahydrofuran
5: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
View Scheme
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

A

2,3,4,6-tetra-O-benzyl-1-deoxy-1-((S)-(4-chloro-3-(4-(tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-β-D-glucopyranose

2,3,4,6-tetra-O-benzyl-1-deoxy-1-((S)-(4-chloro-3-(4-(tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-β-D-glucopyranose

B

C51H51ClO7

C51H51ClO7

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
2: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
3: hydrogenchloride / isopropyl alcohol; methanol
4: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
5: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
View Scheme

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View