As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiry(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS No.:915095-86-2 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on th
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inquiry(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Basic information Product Name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Synonyms: (2-C
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
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inquiry(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS 915095-86-2 2-Chloro-4'-fluoro-5-iodobenzophenone CAS no 915095-86-2 Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)- (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Manufacturer High
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inquiryStock products, own laboratory Product number 33813 English Name (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS Number 915095-86-2 Purity 98%
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryCAS No.915095-86-2 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher S
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
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inquiry(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS:915095-86-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryMolecular weight:245.7 Content:99.5%min Product Name:2-(Methylamino)-5-chlorobenzophenone CAS No. : 1022-13-5 SPECIFICATION: APPEARANCE:white crystal powder PURITY:≥99.5% MELTING POINT:94.0-96.0℃ LOSS ON DRYING:≤0.5% PACKING:pack
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct name: (2-Chloro-5-Iodophenyl)(4-Fluorophenyl)methanone CAS No.: 915095-86-2 Molecule Formula:C13H7ClFIO Molecule Weight:360.55 Purity: 97.0% Package: 25kg/drum Description:Light yellow powder Manufacture Standards:Enterprise Standard
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryProduct name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS No.:915095-86-2 Formula: C13H7ClFIO Structure: Appearance:White to off-white powder Storage:Store sealed at room temperature. Package:25kg/drum Application:(2-Chloro-5-
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiryfluorobenzene
2-chloro-5-iodobenzoic acid
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
With oxalyl dichloride; N,N-dimethyl-formamide at 25 - 30℃; for 5h; | 94% |
Stage #1: fluorobenzene; 2-chloro-5-iodobenzoic acid With oxalyl dichloride In N,N-dimethyl-formamide at 25 - 30℃; for 5h; Stage #2: With aluminum (III) chloride; water at 20 - 30℃; for 6h; | 94% |
With aluminum (III) chloride; oxalyl dichloride In N,N-dimethyl-formamide at 25 - 45℃; Industry scale; | 94% |
2-chloro-5-iodobenzoylchloride
fluorobenzene
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at -5℃; for 6h; | 93.4% |
Stage #1: 2-chloro-5-iodobenzoylchloride; fluorobenzene With aluminum (III) chloride at 0 - 75℃; for 1.5h; Friedel Crafts Acylation; Stage #2: With water at 0 - 25℃; | |
With aluminum (III) chloride at 0 - 25℃; for 1h; Friedel-Crafts Acylation; regioselective reaction; | 121 g |
With aluminum (III) chloride at 25℃; Inert atmosphere; | 105 g |
With aluminum (III) chloride In dichloromethane at 20℃; for 3h; Friedel-Crafts Acylation; Cooling with ice; | 42.1 g |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Stage #1: (2-chloro-5-aminophenyl)(4-fluorophenyl)methanone With sulfuric acid; sodium nitrite In water at 0 - 10℃; Large scale; Stage #2: With urea; potassium iodide In water at 0 - 20℃; for 0.5h; Large scale; | 91.6% |
2-chloro-5-iodobenzoic acid
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / fluorobenzene / 2 h / 15 - 25 °C 2: aluminum (III) chloride / 1 h / 0 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2: aluminum (III) chloride / dichloromethane / 6 h / -5 °C View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C 2: aluminum (III) chloride / dichloromethane / 3 h / 20 °C / Cooling with ice View Scheme |
ortho-chlorobenzoic acid
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sulfuric acid; nitric acid / 2 h / -5 - 20 °C / Large scale 2.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 - 25 °C / Autoclave; Reflux 3.1: aluminum (III) chloride / dichloromethane / 5 h / 0 - 5 °C / Autoclave; Large scale 4.1: iron; ammonium chloride / ethanol; water / 5 h / 78 - 80 °C / Autoclave; Large scale 5.1: sodium nitrite; sulfuric acid / water / 0 - 10 °C / Large scale 5.2: 0.5 h / 0 - 20 °C / Large scale View Scheme |
2-chloro-5-nitrobenzoic acid
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 - 25 °C / Autoclave; Reflux 2.1: aluminum (III) chloride / dichloromethane / 5 h / 0 - 5 °C / Autoclave; Large scale 3.1: iron; ammonium chloride / ethanol; water / 5 h / 78 - 80 °C / Autoclave; Large scale 4.1: sodium nitrite; sulfuric acid / water / 0 - 10 °C / Large scale 4.2: 0.5 h / 0 - 20 °C / Large scale View Scheme |
2-chloro-5-nitrobenzoylchloride
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / dichloromethane / 5 h / 0 - 5 °C / Autoclave; Large scale 2.1: iron; ammonium chloride / ethanol; water / 5 h / 78 - 80 °C / Autoclave; Large scale 3.1: sodium nitrite; sulfuric acid / water / 0 - 10 °C / Large scale 3.2: 0.5 h / 0 - 20 °C / Large scale View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone
Conditions | Yield |
---|---|
With acetylhydroxamic acid; potassium carbonate In dimethyl sulfoxide at 80℃; for 6h; | 95.4% |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
ethanol
(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone
Conditions | Yield |
---|---|
With sodium hydroxide at 50 - 65℃; Temperature; Reagent/catalyst; | 94.3% |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
(S)-3-hydroxytetyrahydrofurane
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 3h; | 91.8% |
Stage #1: (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone; (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 4h; Stage #2: With water at 20 - 21℃; for 1.83333h; | 91.8% |
With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 4h; Industry scale; | 91.8% |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
potassium ethoxide
(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 40℃; for 1h; Cooling with ice; | 87.2% |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
sodium ethanolate
(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; for 1.5h; Solvent; Temperature; Cooling with ice; | 86.5% |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
With triethylsilane; boron trifluoride diethyl etherate In dichloromethane; acetonitrile at 0 - 20℃; | 83% |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
lithium ethoxide
(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 0℃; for 3h; | 82.7% |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium tert-butylate / tetrahydrofuran / 3 h / 16 - 25 °C 2: 1,1,3,3-Tetramethyldisiloxane / aluminum (III) chloride / toluene / 2.5 h / 18 - 26 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C 1.2: 1.83 h / 20 - 21 °C 2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C / Industry scale 2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C / Industry scale 2.2: 20 - 51 °C / Industry scale View Scheme | |
Multi-step reaction with 2 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium tert-butylate / tetrahydrofuran / 20 °C 2: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran / 5 h / Reflux View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium tert-butylate / tetrahydrofuran / 3 h / 16 - 25 °C 2: 1,1,3,3-Tetramethyldisiloxane / aluminum (III) chloride / toluene / 2.5 h / 18 - 26 °C 3: TurboGrignard / tetrahydrofuran / 1.83 h / -15 - 21 °C View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
empagliflozin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C 1.2: 1.83 h / 20 - 21 °C 2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C 3.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.83 h / -21 - -15 °C 3.2: 2.92 h / -25 - -13 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C / Industry scale 2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C / Industry scale 2.2: 20 - 51 °C / Industry scale 3.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.83 h / -21 - -15 °C / Industry scale 3.2: 2.92 h / -25 - -18 °C / Industry scale 3.3: -13 - 19 °C / Industry scale View Scheme | |
Multi-step reaction with 6 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5: hydrogenchloride / isopropyl alcohol; methanol 6: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 20 - 25 °C View Scheme | |
Multi-step reaction with 6 steps 1: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C 2: sodium tetrahydroborate / ethanol / 20 - 25 °C 3: methanesulfonic acid / 20 - 30 °C 4: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere 5: methanesulfonic acid / 20 - 25 °C 6: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / -40 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 6 steps 1: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C 2: sodium tetrahydroborate / ethanol / 20 - 25 °C 3: triethylamine / dichloromethane / 0 - 35 °C 4: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere 5: methanesulfonic acid / 0 - 35 °C 6: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / -40 - 20 °C / Inert atmosphere View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5: hydrogenchloride / isopropyl alcohol; methanol View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5: hydrogenchloride / isopropyl alcohol; methanol 6: triethylamine; dmap / tetrahydrofuran View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5: hydrogenchloride / isopropyl alcohol; methanol 6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5: hydrogenchloride / isopropyl alcohol; methanol 6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4.1: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5.1: hydrogenchloride / isopropyl alcohol; methanol 6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide 7.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C 7.2: 90 °C View Scheme | |
Multi-step reaction with 7 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5: hydrogenchloride / isopropyl alcohol; methanol 6: triethylamine; dmap / tetrahydrofuran 7: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5: hydrogenchloride / isopropyl alcohol; methanol 6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide 7: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5: hydrogenchloride / isopropyl alcohol; methanol 6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide 7: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5: hydrogenchloride / isopropyl alcohol; methanol 6: boron trifluoride diethyl etherate / water 7: triethylsilane View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5: hydrogenchloride / isopropyl alcohol; methanol 6: boron trifluoride diethyl etherate / water View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C 4.1: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2 5.1: hydrogenchloride / isopropyl alcohol; methanol 6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide 7.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C 7.2: 90 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium tert-butylate / tetrahydrofuran / 20 °C 2.1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran / 5 h / Reflux 3.1: n-butyllithium / toluene / 3 h / -20 °C / Inert atmosphere 3.2: 1 h / 0 °C / Inert atmosphere 4.1: toluene / 6 h / 110 °C / Inert atmosphere 5.1: sodium methylate; methanol / 5 h / Reflux View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C 3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C 2: sodium tetrahydroborate / ethanol / 20 - 25 °C View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C 2: sodium tetrahydroborate / ethanol / 20 - 25 °C 3: triethylamine / dichloromethane / 0 - 35 °C View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C 2: sodium tetrahydroborate / ethanol / 20 - 25 °C 3: methanesulfonic acid / 20 - 30 °C View Scheme |
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