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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS NO.915095-86-2

Cas:915095-86-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS No.:915095-86-2 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on th

High purity (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS No.:915095-86-2

Cas:915095-86-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Basic information Product Name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Synonyms: (2-C

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS 915095-86-2 2-Chloro-4'-fluoro-5-iodobenzophenone CAS no 915095-86-2 Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)- (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Manufacturer High

Win-Win chemical Co.Ltd

Stock products, own laboratory Product number 33813 English Name (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS Number 915095-86-2 Purity 98%

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Cas no.915095-86-2 98%

Cas:915095-86-2

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone In stock

Cas:915095-86-2

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

CAS No.915095-86-2 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher S

CAS No.915095-86-2 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 915095-86-2 with best quality

Cas:915095-86-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

Empagliflozin Intermediate 915095-86-2 API Manufacturer

Cas:915095-86-2

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:1 Kilogram

FOB Price: $450.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS:915095-86-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS:915095-86-2

Cas:915095-86-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan BJM Pharm Inc.

Molecular weight:245.7 Content:99.5%min Product Name:2-(Methylamino)-5-chlorobenzophenone CAS No. : 1022-13-5 SPECIFICATION: APPEARANCE:white crystal powder PURITY:≥99.5% MELTING POINT:94.0-96.0℃ LOSS ON DRYING:≤0.5% PACKING:pack

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(2-CHLORO-5-IODOPHENYL)(4-FLUOROPHENYL)METHANONE

Cas:915095-86-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone/High quality/Best price

Cas:915095-86-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (2-Chloro-5-Iodophenyl)(4-Fluorophenyl)methanone CAS No.: 915095-86-2 Molecule Formula:C13H7ClFIO Molecule Weight:360.55 Purity: 97.0% Package: 25kg/drum Description:Light yellow powder Manufacture Standards:Enterprise Standard

Lower Price (2-Chloro-5-Iodophenyl)(4-Fluorophenyl)methanone on stock

Cas:915095-86-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS NO.915095-86-2

Cas:915095-86-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Product name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS No.:915095-86-2 Formula: C13H7ClFIO Structure: Appearance:White to off-white powder Storage:Store sealed at room temperature. Package:25kg/drum Application:(2-Chloro-5-

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Cas:915095-86-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS NO.915095-86-2

Cas:915095-86-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS NO.915095-86-2

Cas:915095-86-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

(2-Chloro-5-iodophenyl)(4-fluorophenyl)Methanone

Cas:915095-86-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

fluorobenzene
462-06-6

fluorobenzene

2-chloro-5-iodobenzoic acid
19094-56-5

2-chloro-5-iodobenzoic acid

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

Conditions
ConditionsYield
With oxalyl dichloride; N,N-dimethyl-formamide at 25 - 30℃; for 5h;94%
Stage #1: fluorobenzene; 2-chloro-5-iodobenzoic acid With oxalyl dichloride In N,N-dimethyl-formamide at 25 - 30℃; for 5h;
Stage #2: With aluminum (III) chloride; water at 20 - 30℃; for 6h;
94%
With aluminum (III) chloride; oxalyl dichloride In N,N-dimethyl-formamide at 25 - 45℃; Industry scale;94%
2-chloro-5-iodobenzoylchloride
281652-58-2

2-chloro-5-iodobenzoylchloride

fluorobenzene
462-06-6

fluorobenzene

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at -5℃; for 6h;93.4%
Stage #1: 2-chloro-5-iodobenzoylchloride; fluorobenzene With aluminum (III) chloride at 0 - 75℃; for 1.5h; Friedel Crafts Acylation;
Stage #2: With water at 0 - 25℃;
With aluminum (III) chloride at 0 - 25℃; for 1h; Friedel-Crafts Acylation; regioselective reaction;121 g
With aluminum (III) chloride at 25℃; Inert atmosphere;105 g
With aluminum (III) chloride In dichloromethane at 20℃; for 3h; Friedel-Crafts Acylation; Cooling with ice;42.1 g
(2-chloro-5-aminophenyl)(4-fluorophenyl)methanone

(2-chloro-5-aminophenyl)(4-fluorophenyl)methanone

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

Conditions
ConditionsYield
Stage #1: (2-chloro-5-aminophenyl)(4-fluorophenyl)methanone With sulfuric acid; sodium nitrite In water at 0 - 10℃; Large scale;
Stage #2: With urea; potassium iodide In water at 0 - 20℃; for 0.5h; Large scale;
91.6%
2-chloro-5-iodobenzoic acid
19094-56-5

2-chloro-5-iodobenzoic acid

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / fluorobenzene / 2 h / 15 - 25 °C
2: aluminum (III) chloride / 1 h / 0 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C
2: aluminum (III) chloride / dichloromethane / 6 h / -5 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C
2: aluminum (III) chloride / dichloromethane / 3 h / 20 °C / Cooling with ice
View Scheme
ortho-chlorobenzoic acid
118-91-2

ortho-chlorobenzoic acid

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sulfuric acid; nitric acid / 2 h / -5 - 20 °C / Large scale
2.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 - 25 °C / Autoclave; Reflux
3.1: aluminum (III) chloride / dichloromethane / 5 h / 0 - 5 °C / Autoclave; Large scale
4.1: iron; ammonium chloride / ethanol; water / 5 h / 78 - 80 °C / Autoclave; Large scale
5.1: sodium nitrite; sulfuric acid / water / 0 - 10 °C / Large scale
5.2: 0.5 h / 0 - 20 °C / Large scale
View Scheme
2-chloro-5-nitrobenzoic acid
2516-96-3

2-chloro-5-nitrobenzoic acid

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 - 25 °C / Autoclave; Reflux
2.1: aluminum (III) chloride / dichloromethane / 5 h / 0 - 5 °C / Autoclave; Large scale
3.1: iron; ammonium chloride / ethanol; water / 5 h / 78 - 80 °C / Autoclave; Large scale
4.1: sodium nitrite; sulfuric acid / water / 0 - 10 °C / Large scale
4.2: 0.5 h / 0 - 20 °C / Large scale
View Scheme
2-chloro-5-nitrobenzoylchloride
25784-91-2

2-chloro-5-nitrobenzoylchloride

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / dichloromethane / 5 h / 0 - 5 °C / Autoclave; Large scale
2.1: iron; ammonium chloride / ethanol; water / 5 h / 78 - 80 °C / Autoclave; Large scale
3.1: sodium nitrite; sulfuric acid / water / 0 - 10 °C / Large scale
3.2: 0.5 h / 0 - 20 °C / Large scale
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone
1459754-40-5

(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone

Conditions
ConditionsYield
With acetylhydroxamic acid; potassium carbonate In dimethyl sulfoxide at 80℃; for 6h;95.4%
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

ethanol
64-17-5

ethanol

(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone
1103738-26-6

(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone

Conditions
ConditionsYield
With sodium hydroxide at 50 - 65℃; Temperature; Reagent/catalyst;94.3%
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(S)-3-hydroxytetyrahydrofurane
86087-23-2

(S)-3-hydroxytetyrahydrofurane

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
915095-87-3

(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 3h;91.8%
Stage #1: (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone; (S)-3-hydroxytetyrahydrofurane With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 4h;
Stage #2: With water at 20 - 21℃; for 1.83333h;
91.8%
With potassium tert-butylate In tetrahydrofuran at 16 - 25℃; for 4h; Industry scale;91.8%
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

potassium ethoxide
917-58-8

potassium ethoxide

(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone
1103738-26-6

(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 40℃; for 1h; Cooling with ice;87.2%
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

sodium ethanolate
141-52-6

sodium ethanolate

(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone
1103738-26-6

(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 1.5h; Solvent; Temperature; Cooling with ice;86.5%
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

1-chloro-2-(4-fluorobenzyl)-4-iodobenzene

1-chloro-2-(4-fluorobenzyl)-4-iodobenzene

Conditions
ConditionsYield
With triethylsilane; boron trifluoride diethyl etherate In dichloromethane; acetonitrile at 0 - 20℃;83%
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

lithium ethoxide
2388-07-0

lithium ethoxide

(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone
1103738-26-6

(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone

Conditions
ConditionsYield
In dimethyl sulfoxide at 0℃; for 3h;82.7%
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran
915095-94-2

(3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 3 h / 16 - 25 °C
2: 1,1,3,3-Tetramethyldisiloxane / aluminum (III) chloride / toluene / 2.5 h / 18 - 26 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C
1.2: 1.83 h / 20 - 21 °C
2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C / Industry scale
2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C / Industry scale
2.2: 20 - 51 °C / Industry scale
View Scheme
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 20 °C
2: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran / 5 h / Reflux
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

C17H16Cl2MgO2

C17H16Cl2MgO2

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran / 3 h / 16 - 25 °C
2: 1,1,3,3-Tetramethyldisiloxane / aluminum (III) chloride / toluene / 2.5 h / 18 - 26 °C
3: TurboGrignard / tetrahydrofuran / 1.83 h / -15 - 21 °C
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

empagliflozin
864070-44-0

empagliflozin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C
1.2: 1.83 h / 20 - 21 °C
2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C
3.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.83 h / -21 - -15 °C
3.2: 2.92 h / -25 - -13 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C / Industry scale
2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C / Industry scale
2.2: 20 - 51 °C / Industry scale
3.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.83 h / -21 - -15 °C / Industry scale
3.2: 2.92 h / -25 - -18 °C / Industry scale
3.3: -13 - 19 °C / Industry scale
View Scheme
Multi-step reaction with 6 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5: hydrogenchloride / isopropyl alcohol; methanol
6: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 20 - 25 °C
View Scheme
Multi-step reaction with 6 steps
1: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C
2: sodium tetrahydroborate / ethanol / 20 - 25 °C
3: methanesulfonic acid / 20 - 30 °C
4: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere
5: methanesulfonic acid / 20 - 25 °C
6: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / -40 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C
2: sodium tetrahydroborate / ethanol / 20 - 25 °C
3: triethylamine / dichloromethane / 0 - 35 °C
4: n-butyllithium / tetrahydrofuran; hexane / -75 - -70 °C / Inert atmosphere
5: methanesulfonic acid / 0 - 35 °C
6: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / -40 - 20 °C / Inert atmosphere
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

C35H59ClO8Si4

C35H59ClO8Si4

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

C24H29ClO8

C24H29ClO8

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
1279691-36-9

(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5: hydrogenchloride / isopropyl alcohol; methanol
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate

(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5: hydrogenchloride / isopropyl alcohol; methanol
6: triethylamine; dmap / tetrahydrofuran
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2S,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

(2S,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5: hydrogenchloride / isopropyl alcohol; methanol
6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2S,3R,4S,5R,6R)-3,4,5-tris(allyloxy)-6-((allyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

(2S,3R,4S,5R,6R)-3,4,5-tris(allyloxy)-6-((allyloxy)methyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5: hydrogenchloride / isopropyl alcohol; methanol
6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

A

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityl triacetate

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityl triacetate

B

C31H35ClO11

C31H35ClO11

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4.1: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5.1: hydrogenchloride / isopropyl alcohol; methanol
6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
7.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
7.2: 90 °C
View Scheme
Multi-step reaction with 7 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5: hydrogenchloride / isopropyl alcohol; methanol
6: triethylamine; dmap / tetrahydrofuran
7: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

A

2,3,4,6-tetra-O-benzyl-1-deoxy-1-((S)-(4-chloro-3-(4-(tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-β-D-glucopyranose

2,3,4,6-tetra-O-benzyl-1-deoxy-1-((S)-(4-chloro-3-(4-(tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-β-D-glucopyranose

B

C51H51ClO7

C51H51ClO7

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5: hydrogenchloride / isopropyl alcohol; methanol
6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
7: aluminum (III) chloride; triethylsilane / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

A

1-chloro-4-(2,3,4,6-tetra-O-allyl-D-glucopyranos-1-yl)-2-(4-(S)-tetrahydrofuran-3-yloxy-benzyl)-benzene

1-chloro-4-(2,3,4,6-tetra-O-allyl-D-glucopyranos-1-yl)-2-(4-(S)-tetrahydrofuran-3-yloxy-benzyl)-benzene

B

C35H43ClO7

C35H43ClO7

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5: hydrogenchloride / isopropyl alcohol; methanol
6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
7: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

C23H27ClO7

C23H27ClO7

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5: hydrogenchloride / isopropyl alcohol; methanol
6: boron trifluoride diethyl etherate / water
7: triethylsilane
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

C23H27ClO8

C23H27ClO8

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5: hydrogenchloride / isopropyl alcohol; methanol
6: boron trifluoride diethyl etherate / water
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2R,3R,4R,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

(2R,3R,4R,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2.1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
4.1: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2
5.1: hydrogenchloride / isopropyl alcohol; methanol
6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide
7.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.5 h / 15 - 20 °C
7.2: 90 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 20 °C
2.1: sodium tetrahydroborate; aluminum (III) chloride / tetrahydrofuran / 5 h / Reflux
3.1: n-butyllithium / toluene / 3 h / -20 °C / Inert atmosphere
3.2: 1 h / 0 °C / Inert atmosphere
4.1: toluene / 6 h / 110 °C / Inert atmosphere
5.1: sodium methylate; methanol / 5 h / Reflux
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

(1R,2S,3R,4R,5S)-1-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol

(1R,2S,3R,4R,5S)-1-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 7 - 10 °C
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C
3: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

C17H16ClIO3

C17H16ClIO3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C
2: sodium tetrahydroborate / ethanol / 20 - 25 °C
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

C20H24ClIO3Si

C20H24ClIO3Si

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C
2: sodium tetrahydroborate / ethanol / 20 - 25 °C
3: triethylamine / dichloromethane / 0 - 35 °C
View Scheme
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

C18H18ClIO3

C18H18ClIO3

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran / 2 - 10 °C
2: sodium tetrahydroborate / ethanol / 20 - 25 °C
3: methanesulfonic acid / 20 - 30 °C
View Scheme

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