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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

3-Isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Isobutylglutaric acid anhydride

Cas:185815-59-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--185815-59-2--3-isobutylglutaric anhydride factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable bus

TIANFUCHEM--185815-59-2--3-isobutylglutaric anhydride factory price

Cas:185815-59-2

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

3-isobutylglutaric anhydride CAS 185815-59-2

Cas:185815-59-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 185815-59-2 with competitive price

Cas:185815-59-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 3-Isobutylglutaric anhydride Synonyms: 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione CAS:185815-59-2 MF: C9H14O3 Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application: organic synthesis Transp

3-Isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

3-isobutylglutaric anhydride CAS NO 185815-59-2

Cas:185815-59-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2H-Pyran-2,6(3H)-dione,dihydro-4-(2-methylpropyl)- 185815-59-2

Cas:185815-59-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

3-isobutylglutaric anhydride CAS:185815-59-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality org

3-isobutylglutaric anhydride CAS:185815-59-2

Cas:185815-59-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

3-isobutylglutaric anhydride CAS NO.185815-59-2

Cas:185815-59-2

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2H-Pyran-2,6(3H)-dione,dihydro-4-(2-methylpropyl)-

Cas:185815-59-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

3-Isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2H-Pyran-2,6(3H)-dione,dihydro-4-(2-methylpropyl)-

Cas:185815-59-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 3-Isobutylglutaric Anhydride CAS No.: 185815-59-2 Molecule Formula:C9H14O3 Molecule Weight:170.21 Purity: 98.0% Package: 200kg/drum Description:Colorless to light yellow liquid Manufacture Standards:Enterprise Standard

High Quality 3-Isobutylglutaric Anhydride

Cas:185815-59-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Factory Sells3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:0

Negotiable

Type:Trading Company

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

3-isobutylglutaricanhydride

Cas:185815-59-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Cas no.185815-59-2 98% 3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

3-isobutylglutaric anhydride

Cas:185815-59-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Synthetic route

5-methyl-3-carboxymethylhexanoic acid
75143-89-4

5-methyl-3-carboxymethylhexanoic acid

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

Conditions
ConditionsYield
With propionic acid anhydride at 140 - 145℃; for 6h;91%
With acetyl chloride at 20 - 55℃; for 3.08333h; Inert atmosphere;85%
at 150℃; unter vermindertem Druck;
isovaleraldehyde
590-86-3

isovaleraldehyde

cyanoacetic acid amide
107-91-5

cyanoacetic acid amide

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

Conditions
ConditionsYield
Stage #1: isovaleraldehyde; cyanoacetic acid amide; piperidine In dichloromethane; water at 22 - 25℃; for 6h;
Stage #2: With hydrogenchloride In water for 20h; Heating;
Stage #3: With acetic anhydride for 2h; Heating; Further stages.;
65%
diethyl 2-(3-methylbutylidene)malonate
51615-30-6

diethyl 2-(3-methylbutylidene)malonate

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: di-n-propylamine / 16 h / 15 - 55 °C
2: hydrogen bromide / water / 72 h / 100 °C
3: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
View Scheme
2-isobutyl-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester
102710-09-8

2-isobutyl-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen bromide / water / 72 h / 100 °C
2: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
View Scheme
isovaleraldehyde
590-86-3

isovaleraldehyde

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: piperidine; pyridine; acetic acid / hexane / 48 h / Reflux; Inert atmosphere
2: di-n-propylamine / 16 h / 15 - 55 °C
3: hydrogen bromide / water / 72 h / 100 °C
4: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: tetramethyl ammoniumhydroxide; trimethyldodecylammonium chloride / ethanol / 6 h / 25 °C
2: water; hydrogenchloride / 30 h / 140 °C / pH 1 - 2
3: acetic anhydride / 2 h / 120 °C
View Scheme
2,4-dicyano-3-isobutylglutaramide

2,4-dicyano-3-isobutylglutaramide

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water; hydrogenchloride / 30 h / 140 °C / pH 1 - 2
2: acetic anhydride / 2 h / 120 °C
View Scheme
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid
181289-15-6

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid

Conditions
ConditionsYield
With ammonia In water at -10 - 40℃; for 1.5h;100%
With ammonium hydroxide at 10℃; for 2h; Temperature;95%
Stage #1: 3-isobutylglutaric anhydride With ammonia In tert-butyl methyl ether; water at 0 - 20℃;
Stage #2: With hydrogenchloride In tert-butyl methyl ether; water pH=2;
80.4%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

Cyclohexanethiol
1569-69-3

Cyclohexanethiol

(-)-3-cyclohexylsulfanylcarbonylmethyl-5-methyl-hexanoic acid
1237492-10-2

(-)-3-cyclohexylsulfanylcarbonylmethyl-5-methyl-hexanoic acid

Conditions
ConditionsYield
In tert-butyl methyl ether at 20℃; for 72h; Product distribution / selectivity; Inert atmosphere;100%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

(3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid
930585-94-7

(3R)-5-methyl-3-(2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid

Conditions
ConditionsYield
Stage #1: 3-isobutylglutaric anhydride; (R)-1-phenyl-ethyl-amine With dmap In ethyl acetate at 0 - 5℃; for 1.75 - 2.33h;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate
Stage #3: With hydrogenchloride In water pH=2 - 2.5; Product distribution / selectivity;
99.3%
Stage #1: 3-isobutylglutaric anhydride; (R)-1-phenyl-ethyl-amine With dmap In isopropyl alcohol at 0 - 5℃; for 1.75 - 2.33h;
Stage #2: With sodium hydrogencarbonate In water; isopropyl alcohol
Stage #3: With hydrogenchloride In water pH=2 - 2.5; Product distribution / selectivity;
99.34%
Stage #1: 3-isobutylglutaric anhydride; (R)-1-phenyl-ethyl-amine With dmap In toluene at 0 - 5℃; for 1.75 - 2.33h;
Stage #2: With sodium hydrogencarbonate In water; toluene
Stage #3: With hydrogenchloride In water pH=2 - 2.5; Product distribution / selectivity;
99.6%
methanol
67-56-1

methanol

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

3-isobutylglutaric acid methyl ester
181289-11-2

3-isobutylglutaric acid methyl ester

Conditions
ConditionsYield
at 20℃; for 16 - 18h; Product distribution / selectivity;97%
Stage #1: methanol; 3-isobutylglutaric anhydride With triethylamine at 20℃; for 16 - 18h;
Stage #2: With hydrogenchloride; water Product distribution / selectivity;
95%
methanol
67-56-1

methanol

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(3R)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid
156048-92-9

(3R)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid

Conditions
ConditionsYield
With N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide In tert-butyl methyl ether at -20℃; for 14h; optical yield given as %ee; enantioselective reaction;96%
Stage #1: methanol; 3-isobutylglutaric anhydride; Q-BTBSA In tert-butyl methyl ether at -20℃; for 14h;
Stage #2: With hydrogenchloride In tert-butyl methyl ether; water Product distribution / selectivity;
96%
With Quinine In toluene at -70℃; for 17h; Product distribution / selectivity;95%
With Cinchonidin In toluene at -50℃; for 15h; Product distribution / selectivity;
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

phenylmethanethiol
100-53-8

phenylmethanethiol

(R)-3-(2-(benzylthio)-2-oxoethyl)-5-methylhexanoic acid
1432752-42-5

(R)-3-(2-(benzylthio)-2-oxoethyl)-5-methylhexanoic acid

Conditions
ConditionsYield
With N-((1R,2R)-2-(dimethylamino)-1-(4-nitrophenyl)-3-(trityloxy)propyl)-3,5-bis(trifluoromethyl)benzene-sulfonamide In tert-butyl methyl ether at -20℃; Inert atmosphere; Schlenk technique; enantioselective reaction;96%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

phenylmethanethiol
100-53-8

phenylmethanethiol

C16H22O3S

C16H22O3S

Conditions
ConditionsYield
With (S)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N,N,4-trimethyl-N-(4-nitrobenzyl)(pentan-1-ylammonium) chloride In tert-butyl methyl ether at -10℃; for 16h; Solvent; Reagent/catalyst; Inert atmosphere;96%
methanol
67-56-1

methanol

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid
181289-25-8

(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid

Conditions
ConditionsYield
With Cinchonin In toluene at -78 - -50℃; for 15 - 19h; Product distribution / selectivity;90%
With quinidine In toluene at -78 - -50℃; for 2 - 96h; Product distribution / selectivity;87%
In tert-butyl methyl ether at 20 - 25℃; for 3h; Enzymatic reaction;n/a
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

isopropyl alcohol
67-63-0

isopropyl alcohol

isopropyl {4-methyl-2-[(1-carboxy)-methyl]-pentyl}-carbamate
1082077-22-2

isopropyl {4-methyl-2-[(1-carboxy)-methyl]-pentyl}-carbamate

Conditions
ConditionsYield
Stage #1: isopropyl alcohol With sodium azide; zinc(II) chloride at 20℃; Inert atmosphere;
Stage #2: 3-isobutylglutaric anhydride at 75 - 80℃;
Stage #3: With hydrogenchloride; sodium nitrite In water at -5 - 10℃;
90%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

1-hydroxy-4-(2-methylpropyl)piperidine-2,6-dione

1-hydroxy-4-(2-methylpropyl)piperidine-2,6-dione

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium hydroxide In water; isopropyl alcohol at 60 - 65℃; for 4h;90%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

3-hydrazinocarbonylmethyl-5-methyl-hexanoic acid
1159446-16-8

3-hydrazinocarbonylmethyl-5-methyl-hexanoic acid

Conditions
ConditionsYield
With sodium hydroxide; hydrazine In water; toluene at -5 - 5℃; for 2 - 3h; Product distribution / selectivity;86%
With sodium hydroxide; hydrazine In water; toluene at -5 - 5℃; for 2 - 3h; Product distribution / selectivity;86%
With sodium hydroxide; hydrazine In water at -5 - 5℃; for 2 - 3h; Product distribution / selectivity;
With sodium hydroxide; hydrazine In water at -5 - 5℃; for 2 - 3h; Product distribution / selectivity;
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

4-Bromobutyl acetate
4753-59-7

4-Bromobutyl acetate

C14H26O4

C14H26O4

Conditions
ConditionsYield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0); zinc In N,N-dimethyl acetamide at 80℃; for 12h;83%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

1-bromo-6-benzyloxyhexane
54247-27-7

1-bromo-6-benzyloxyhexane

C21H34O3

C21H34O3

Conditions
ConditionsYield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0); zinc In N,N-dimethyl acetamide at 80℃; for 12h;80%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(S)-1-phenyl-ethylamine
2627-86-3

(S)-1-phenyl-ethylamine

(3S)-5-methyl-3-(2-oxo-2-{[(1S)-1-phenylethyl]amino}ethyl)hexanoic acid
930280-42-5

(3S)-5-methyl-3-(2-oxo-2-{[(1S)-1-phenylethyl]amino}ethyl)hexanoic acid

Conditions
ConditionsYield
With dmap In toluene at -15 - -10℃; Temperature; Concentration;73%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(2E)-3-phenyl-2-propen-1-ol
4407-36-7

(2E)-3-phenyl-2-propen-1-ol

(-)-(R)-3-isobutyl-pentanedioic acid mono-(3-phenyl-allyl) ester
949890-69-1

(-)-(R)-3-isobutyl-pentanedioic acid mono-(3-phenyl-allyl) ester

Conditions
ConditionsYield
With Quinine In toluene at -30℃; for 24h;72%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

3-Phenylpropenol
104-54-1

3-Phenylpropenol

(-)-(R)-3-isobutyl-pentanedioic acid mono-(3-phenyl-allyl) ester
949890-69-1

(-)-(R)-3-isobutyl-pentanedioic acid mono-(3-phenyl-allyl) ester

Conditions
ConditionsYield
Stage #1: 3-isobutylglutaric anhydride; 3-Phenylpropenol With quinine In toluene at -35℃; for 24.25h;
Stage #2: With 1-Adamantanamine In tert-butyl methyl ether; isopropyl alcohol at 25 - 45℃; for 6h;
Stage #3: With hydrogenchloride In water; toluene Product distribution / selectivity;
69%
Stage #1: 3-isobutylglutaric anhydride; 3-Phenylpropenol With quinindine In di-isopropyl ether; water; toluene at -35℃; for 24.25h;
Stage #2: With (S)-1-phenyl-ethylamine In di-isopropyl ether; water at 25 - 35℃; for 4h;
Stage #3: With hydrogenchloride In water; toluene Product distribution / selectivity;
66%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

3-Phenylpropenol
104-54-1

3-Phenylpropenol

(S)-3-(2-(cinnamyloxy)-2-oxoethyl)-5-methylhexanoic acid

(S)-3-(2-(cinnamyloxy)-2-oxoethyl)-5-methylhexanoic acid

Conditions
ConditionsYield
Stage #1: 3-isobutylglutaric anhydride; 3-Phenylpropenol With quinindine In toluene at -38 - -35℃; for 24.25h;
Stage #2: With (S)-1-phenyl-ethylamine In di-isopropyl ether; water at 25 - 35℃; for 4h;
Stage #3: With hydrogenchloride In water; toluene
65%
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

aniline
62-53-3

aniline

3-isobutyl-N-phenyl-glutaramic acid

3-isobutyl-N-phenyl-glutaramic acid

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

phenylmagnesium chloride
100-59-4

phenylmagnesium chloride

A

(R)-5-Methyl-3-(2-oxo-2-phenyl-ethyl)-hexanoic acid

(R)-5-Methyl-3-(2-oxo-2-phenyl-ethyl)-hexanoic acid

B

(S)-5-Methyl-3-(2-oxo-2-phenyl-ethyl)-hexanoic acid

(S)-5-Methyl-3-(2-oxo-2-phenyl-ethyl)-hexanoic acid

Conditions
ConditionsYield
With (-)-sparteine In toluene at -78℃; for 24h; Grignard reaction; Title compound not separated from byproducts;
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

A

(S)-3-{[(2S-1,3,3,trimethylbicyclo[2.2.1]heptan-2-yloxy)carbonyl]methyl}-5-methylhexanoic aic
1057113-79-7

(S)-3-{[(2S-1,3,3,trimethylbicyclo[2.2.1]heptan-2-yloxy)carbonyl]methyl}-5-methylhexanoic aic

B

(R)-3-{[(2S-1,3,3,trimethylbicyclo[2.2.1]heptan-2-yloxy)carbonyl]methyl}-5-methylhexanoic aic
1057113-81-1

(R)-3-{[(2S-1,3,3,trimethylbicyclo[2.2.1]heptan-2-yloxy)carbonyl]methyl}-5-methylhexanoic aic

Conditions
ConditionsYield
Stage #1: (1S)-1,3,3-trimethyl-norbornan-2endo-ol With sodium hydride In toluene at 80℃;
Stage #2: 3-isobutylglutaric anhydride In toluene at 0 - 20℃; for 3h;
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

A

(S)-4-(((S)-carboxy(phenyl)methoxy)carbonyl)-3-isobutylbutanoic acid
959624-21-6

(S)-4-(((S)-carboxy(phenyl)methoxy)carbonyl)-3-isobutylbutanoic acid

B

(R)-4-(((S)-carboxy(phenyl)methoxy)carbonyl)-3-isobutylbutanoic acid
1057113-78-6

(R)-4-(((S)-carboxy(phenyl)methoxy)carbonyl)-3-isobutylbutanoic acid

Conditions
ConditionsYield
Stage #1: (S)-Mandelic acid With sodium hydride In toluene Heating / reflux;
Stage #2: 3-isobutylglutaric anhydride In toluene at 20℃; for 6h;
methanol
67-56-1

methanol

3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Conditions
ConditionsYield
Stage #1: methanol; 3-isobutylglutaric anhydride With quinidine at -50℃; for 17h;
Stage #2: With ammonia In water at 20 - 40℃; for 72h;
Stage #3: With hydrogenchloride In water pH=3; Product distribution / selectivity;
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

benzyl alcohol
100-51-6

benzyl alcohol

A

(S)-3-isobutyl-pentanedioic acid monobenzyl ester

(S)-3-isobutyl-pentanedioic acid monobenzyl ester

B

(R)-3-isobutyl-pentanedioic acid monobenzyl ester

(R)-3-isobutyl-pentanedioic acid monobenzyl ester

Conditions
ConditionsYield
With Quinine In toluene at -25℃; for 23h; Title compound not separated from byproducts.;
With quinine In toluene at 20℃; for 20h; optical yield given as %ee; enantioselective reaction;
With xanthene-9-carboxylic acid; quinine In toluene at 20℃; for 20h; optical yield given as %ee; enantioselective reaction;
With xanthene-9-carboxylic acid; quinindine In toluene at 20℃; for 22h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
With xanthene-9-carboxylic acid; quinine In toluene at 20℃; for 18h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(-)-(S)-5-methyl-3-[(3-phenyl-allyloxycarbonylamino)methyl]-hexanoic acid 3-phenyl-allyl ester

(-)-(S)-5-methyl-3-[(3-phenyl-allyloxycarbonylamino)methyl]-hexanoic acid 3-phenyl-allyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 72 percent / quinine / toluene / 24 h / -30 °C
2.1: triethylamine; diphenylphosphoryl azide / toluene / 20 - 90 °C
2.2: toluene / Heating
View Scheme
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(-)-(S)-3-(benzyloxycarbonylamino-methyl)-5-methyl-hexanoic acid 3-phenyl-allyl ester
949890-73-7

(-)-(S)-3-(benzyloxycarbonylamino-methyl)-5-methyl-hexanoic acid 3-phenyl-allyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 72 percent / quinine / toluene / 24 h / -30 °C
2.1: triethylamine; diphenylphosphoryl azide / toluene / 20 - 90 °C
2.2: toluene / Heating
View Scheme
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(-)-(S)-3-(benzyloxycarbonylamino-methyl)-5-methyl-hexanoic acid
949890-75-9

(-)-(S)-3-(benzyloxycarbonylamino-methyl)-5-methyl-hexanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 72 percent / quinine / toluene / 24 h / -30 °C
2.1: triethylamine; diphenylphosphoryl azide / toluene / 20 - 90 °C
2.2: toluene / Heating
3.1: 12.7 g / morpholine; triphenylphosphine / Pd(OAc)2 / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: N-((1R,2R)-2-(dimethylamino)-1-(4-nitrophenyl)-3-(trityloxy)propyl)-3,5-bis(trifluoromethyl)benzene-sulfonamide / tert-butyl methyl ether / -20 °C / Inert atmosphere; Schlenk technique
2.1: triethylamine; diphenyl phosphoryl azide / toluene / 20 - 90 °C / Inert atmosphere; Schlenk technique
3.1: toluene / Reflux; Inert atmosphere; Schlenk technique
4.1: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Schlenk technique
4.2: 0 °C / Inert atmosphere; Schlenk technique
View Scheme
Multi-step reaction with 3 steps
1.1: (S)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N,N,4-trimethyl-N-(4-nitrobenzyl)(pentan-1-ylammonium) chloride / tert-butyl methyl ether / 16 h / -10 °C / Inert atmosphere
2.1: triethylamine; diphenylphosphoranyl azide / toluene / 0.25 h / 25 - 85 °C
2.2: 12 h / Reflux
3.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran / 4 h / 20 °C
View Scheme
3-isobutylglutaric anhydride
185815-59-2

3-isobutylglutaric anhydride

(S)-4-isobutyl-pyrrolidin-2-one
181289-23-6

(S)-4-isobutyl-pyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 72 percent / quinine / toluene / 24 h / -30 °C
2.1: triethylamine; diphenylphosphoryl azide / toluene / 20 - 90 °C
2.2: toluene / Heating
3.1: morpholine; triphenylphosphine / Pd(OAc)2 / ethanol / 3 h / Heating
View Scheme

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