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Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, Nuevo Laredo, Mexico, Vancouver, Canada, Amsterdam, The Netherlands and Melbourne, Australia. Overseas warehouses can provide some of the best selling products. We look forward to cooperating with strong loc

Top quality Pregabalin powder cas 148553-50-8 Safely delivered to USA, Mexico, Canada

Cas:148553-50-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe

99% Pregabalin CAS 148553-50-8

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Pregabalin Manufacturer/High quality/Best price/In stock

Cas:148553-50-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hubei Vanz Pharm Co.,Ltd

Wuhan Vanz Pharm Inc Manufacturer Supply Top Quality CAS 148553-50-8 pregabalin powder. Pregabalin, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder. Its use for epilepsy is as an add-on the

Manufacturer Supply Top Quality CAS 148553-50-8 pregabalin powder

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $400.0

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or almost white powder white powder Identification A

High purity Various Specifications pregabalin CAS:148553-50-8

Cas:148553-50-8

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply Pregabalin raw material / pregabalin powder/CAS:148553-50-8 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support

Pregabalin raw material / pregabalin powder/CAS:148553-50-8

Cas:148553-50-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hefei Zhaobo Technology Co., Ltd.

High quality Pregabalin CAS NO. 148553-50-8 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict qua

High quality Pregabalin CAS NO. 148553-50-8

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Trading Company

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Wuhan Xinhao Biotechnology Co., Ltd.

1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .

High Purity Pregabalin With Safety Shipping CAS NO.148553-50-8

Cas:148553-50-8

Min.Order:100 Gram

FOB Price: $10.0 / 100.0

Type:Trading Company

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Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

Pregabalin for nerve pain

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $0.1 / 0.2

Type:Lab/Research institutions

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Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Top quality Pregabalin powder cas 148553-50-8 Safely delivered to USA, Mexico, Canada CAS NO.148553-50-8

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

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Qiuxian Yanjia Trading Co., Ltd

Appearance:powder Storage:Cool & Dry place Package:Choose the most suitable packaging according to the product Application:TEST Port:Guangdong

Pregabalin CAS 148553-50-8 good quality pregabalin

Cas:148553-50-8

Min.Order:1 box

FOB Price: $190.0 / 220.0

Type:Trading Company

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Pregabalin

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Store at RT

High purity 99% Factory price Pregabalin In stock 148553-50-8 CAS FACTORY

Cas:148553-50-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

Professional Supplier pregabalin crystal powder CAS 148553-50-8 AKS

Cas:148553-50-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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DB BIOTECH CO., LTD

Quick Details CAS No.: 148553-50-8 Other Names: Pregabalin MF: C8H17NO2 EINECS No.: 232-678-0 Place of Origin: Shandong, China (Main

Pregabalin

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $38.0 / 40.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Pregabalin

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $15.0 / 25.0

Type:Lab/Research institutions

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Hebei Weimiao Import and Export Trade Co., Ltd.

Quick Details Classification: Pharmaceutical Intermediates Cas NO.: 148553-50-8 Name: Pregabalin Molecular Formula: C8H17NO2 Melting Point: 194-196°C Boiling Point: 274 °C at 760 mmHg Refractive index:1.464 Flash Point: 119.5 °C

CAS?148553-50-8?Pregabalin

Cas:148553-50-8

Min.Order:1 Milligram

FOB Price: $30.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Super Pregabalin CAS NO.148553-50-8

Cas:148553-50-8

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Hangzhou Hysen Pharma co.,Ltd.

We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and

Pregabalin CAS148553-50-8

Cas:148553-50-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Luyunjia Chemistry Xiamen Limited

Quick Details CAS No.: 148553-50-8 Other Names: Pregabalin MF: C8H17NO2 EINECS No.: N/A Place of Origin: Zhejiang, China (Mainland) Type: diabetes

lower price 148553-50-8 Pregabalin

Cas:148553-50-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhengzhou Yuanli Biological Technology Co., Ltd.

1. Molecular formula: C8H17NO2 2. Molecular weight: 159.23 3. Packing: 25kg/drum 4. Appearance: white to almost white powder 5. Melting range: 194-196℃ 6. Annual supply: 10 tons 7. Grade: pharmaceutical grade 8. Loss on drying: 0.5%max 9. Ass

Biggest manufacturer of Pregabalin

Cas:148553-50-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory supply 99% Pregabalin powder

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $50.0 / 800.0

Type:Trading Company

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Kono Chem Co.,Ltd

Superiority KONO is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in your r

High quality Pregabalin 99% powder with best price

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $200.0 / 250.0

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Pregabalin 148553-50-8 API

Cas:148553-50-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Off-white to white powder Storage:Store at RT Package:1kg/foi

Manufacturer supply Pregabalin CAS 148553-50-8 of USP standard

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $160.0 / 300.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Quanao supply 99% Pregabalin Powder for Capsules cas:148553-50-8

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $299.0 / 329.0

Type:Manufacturers

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Hefei TNJ chemical industry co.,ltd

Specification Appearance White off-white crystalline powder Loss on

Pregabalin, CAS No.: 148553-50-8

Cas:148553-50-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 148553-50-8 Pregabalin Manufacturer

Cas:148553-50-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Xi`an Eastling Biotech Co., Ltd.

pregabalin CAS: 148553-50-8 Molecular Formula: C8H17NO2 Home Product Category other other 148553-50-8 148553-50-8 - Names and Identifiers Name pregabalin Synonyms CI 1008 CI-1008 PD 144723 Pregablin PD-

Factory high quality Pregabalin

Cas:148553-50-8

Min.Order:1 Kilogram

FOB Price: $159.0 / 170.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:pregabalin CAS NO:148553-50-8 Grade:Medical scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Product Techn

pregabalinl CAS:148553-50-8 Chinese manufacturers high-quality

Cas:148553-50-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Synthetic route

(R)-3-((tert-butoxycarbonylamino)methyl)-5-methylhex-4-enoic acid
1021167-91-8

(R)-3-((tert-butoxycarbonylamino)methyl)-5-methylhex-4-enoic acid

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium dihydroxide In methanol at 20℃; under 4560.31 Torr;100%
(S)-3-azidomethyl-5-methylhexanoic acid
157422-27-0

(S)-3-azidomethyl-5-methylhexanoic acid

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol for 3h;99%
With hydrogen; palladium 10% on activated carbon In methanol for 3h;99%
palladium on activated charcoal In tert-butyl methyl ether59%
palladium on activated charcoal In tert-butyl methyl ether59%
(S)-3-azidomethyl-5-methyl-hexanoic acid ethyl ester
951792-40-8

(S)-3-azidomethyl-5-methyl-hexanoic acid ethyl ester

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In methanol for 3h;99%
Multi-step reaction with 2 steps
1: 90.9 percent / LiOH*H2O / tetrahydrofuran; methanol; H2O / 0.25 h / Heating
2: 99 percent / H2 / Pd/C / methanol / 3 h
View Scheme
C23H29NO4
1253690-87-7

C23H29NO4

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 7500.75 Torr; for 15h;99%
(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
181289-33-8

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
Stage #1: (3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid With sodium hydroxide In water at 0 - 10℃; for 0.166667h; Hofmann Rearrangement; Large scale;
Stage #2: With sodium hypochlorite In water at 0 - 75℃; for 1h; Temperature; Hofmann Rearrangement; Large scale;
97.7%
Stage #1: (3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid With sodium hypochlorite; sodium hydroxide In water at -15 - -10℃; for 3h; Industrial scale;
Stage #2: With sodium sulfite at -10 - 40℃; for 5h; Reagent/catalyst; Temperature; Industrial scale; Further stages;
85%
With sodium hypochlorite; sodium hydroxide In water at 10 - 47℃; Temperature;83%
5-methyl-3-(nitromethyl)hexanoic acid
181289-21-4

5-methyl-3-(nitromethyl)hexanoic acid

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 24h; Reagent/catalyst; Solvent; Time; Temperature;96%
With palladium on activated charcoal; hydrogen In methanol; water at 20℃; under 2660.18 - 3040.2 Torr; for 16h;
(S)-(+)-5-methyl-3-(nitromethyl)hexanoic acid
181289-45-2

(S)-(+)-5-methyl-3-(nitromethyl)hexanoic acid

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With hydrogen In methanol; water at 18℃;95%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; Solvent;77%
With hydrogen; 5%-palladium/activated carbon In methanol for 5 - 8h;35%
With hydrogen; 5% Pd(II)/C(eggshell) In methanol35%
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 48h;
(S)-3-(aminomethyl)-5-methyl-N-((S)-1-phenylethyl)hexanamide
1310495-04-5

(S)-3-(aminomethyl)-5-methyl-N-((S)-1-phenylethyl)hexanamide

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 65℃; for 6h; Reagent/catalyst;95%
Stage #1: (S)-3-(aminomethyl)-5-methyl-N-((S)-1-phenylethyl)hexanamide With water; hydrogen bromide at 100 - 110℃; for 5h;
Stage #2: With sodium hydroxide In water
83%
C10H17NO3

C10H17NO3

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
Stage #1: C10H17NO3 With hydrogenchloride In water for 24h; Reflux;
Stage #2: With sodium hydroxide In water pH=7.2;
95%
sodium 5-methyl-3-nitromethyl-hexanoate

sodium 5-methyl-3-nitromethyl-hexanoate

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With hydrogen In methanol at 20℃; under 760.051 Torr; for 6h; Reagent/catalyst;95%
(S)-4-isobutyl-pyrrolidin-2-one
181289-23-6

(S)-4-isobutyl-pyrrolidin-2-one

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With ethanol; sodium hydroxide at 40℃; for 5h; Green chemistry;94.1%
With lipase from Rhizopus delemar; sodium carbonate In water at 35℃; for 5h; pH=9 - 10; Reagent/catalyst; Solvent; Temperature; Enzymatic reaction;93.2%
With hydrogenchloride In water at 100 - 106℃; for 10h;88%
(S)-pregabalin-(-)-O,O'-dibenzoyl-L-tartrate
1078737-39-9

(S)-pregabalin-(-)-O,O'-dibenzoyl-L-tartrate

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With ammonia In methanol; water at 0℃;93%
{(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester
930280-44-7

{(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
Stage #1: {(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester With hydrogen bromide In water for 3h; Heating / reflux;
Stage #2: With sodium hydroxide In water at 20℃; pH=3;
Stage #3: With tributyl-amine In 2-methyl-propan-1-ol at 2℃; for 1h; Product distribution / selectivity;
90%
Stage #1: {(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester With sulfuric acid In water at 115 - 120℃; for 5 - 10h;
Stage #2: With sodium hydroxide In water at 20 - 25℃; pH=1;
Stage #3: With tributyl-amine In 2-methyl-propan-1-ol pH=4; Product distribution / selectivity;
40.4%
Stage #1: {(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester With hydrogenchloride; sodium chloride; phenol In water at 105 - 110℃; for 15 - 24h;
Stage #2: With sodium hydroxide In water at 20 - 25℃; pH=1;
Stage #3: With tributyl-amine In 2-methyl-propan-1-ol pH=4 - 4.5; Product distribution / selectivity;
Stage #1: {(S)-4-methyl-2-[((S)-1-phenylethylcarbamoyl)methyl]pentyl}carbamic acid methyl ester With hydrogenchloride; sodium chloride; phenol In methanol; water at 105 - 110℃; for 15 - 24h;
Stage #2: With sodium hydroxide In methanol; water at 20 - 25℃; pH=1;
Stage #3: With tributyl-amine In 2-methyl-propan-1-ol pH=4 - 5; Product distribution / selectivity;
(S)-3-(isopropoxycarbonyl-aminomethyl)-5-methyl-hexanoic acid (S)-(-)-1-phenylethylamine salt
1082077-26-6

(S)-3-(isopropoxycarbonyl-aminomethyl)-5-methyl-hexanoic acid (S)-(-)-1-phenylethylamine salt

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
Stage #1: (S)-3-(isopropoxycarbonylamino-methyl)-5-methyl-hexanoic acid (S)-(-)-1-phenylethylamine salt With hydrogenchloride In water; toluene for 0.166667 - 0.25h;
Stage #2: With hydrogenchloride; water at 90℃; for 24 - 48h;
Stage #3: With methylamine In water pH=~ 6;
88%
Stage #1: (S)-3-(isopropoxycarbonylamino-methyl)-5-methyl-hexanoic acid (S)-(-)-1-phenylethylamine salt With hydrogenchloride In water at 90℃; Inert atmosphere;
Stage #2: With methylamine In water; toluene at 0 - 90℃; for 1h; pH=6;
88%
Stage #1: (S)-3-(isopropoxycarbonylamino-methyl)-5-methyl-hexanoic acid (S)-(-)-1-phenylethylamine salt With hydrogenchloride; water at 90 - 95℃; for 24h;
Stage #2: With sodium hydroxide; water at 0 - 5℃; for 1h; Product distribution / selectivity;
82%
isopropyl (S)-{4-methyl-2-[(1-methoxycarbonyl)methyl]pentyl}-carbamate
1082077-19-7

isopropyl (S)-{4-methyl-2-[(1-methoxycarbonyl)methyl]pentyl}-carbamate

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
Stage #1: isopropyl (S)-{4-methyl-2-[(1-methoxycarbonyl)methyl]pentyl}-carbamate With hydrogenchloride; water at 90℃; for 24 - 48h;
Stage #2: With water; methylamine pH=~ 6; Product distribution / selectivity;
88%
(S)-(+)-pregabalin (2R,3R)-(+)-tartaric acid

(S)-(+)-pregabalin (2R,3R)-(+)-tartaric acid

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In water; isopropyl alcohol at 20 - 25℃; pH=7.0 - 7.5; Product distribution / selectivity;88%
With ammonium hydroxide In water at 0 - 65℃; Product distribution / selectivity;81.1%
(S)-pregabalin O,O'-di-p-toluoyl-(D)-tartrate

(S)-pregabalin O,O'-di-p-toluoyl-(D)-tartrate

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In water; isopropyl alcohol at 20 - 25℃; pH=7.0 - 7.5;87%
(S)-3-bromomethyl-5-methyl-hexanoic acid ethyl ester
951792-39-5

(S)-3-bromomethyl-5-methyl-hexanoic acid ethyl ester

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
Stage #1: (S)-3-bromomethyl-5-methyl-hexanoic acid ethyl ester With sodium azide In N,N-dimethyl-formamide at 20℃; for 5h;
Stage #2: With 5%-palladium/activated carbon; hydrogen at 20℃; for 5h;
84.5%
Multi-step reaction with 3 steps
1: 92.9 percent / NaN3 / dimethylformamide / 4 h / 20 °C
2: 90.9 percent / LiOH*H2O / tetrahydrofuran; methanol; H2O / 0.25 h / Heating
3: 99 percent / H2 / Pd/C / methanol / 3 h
View Scheme
C8H8O3*C8H17NO2
1026095-29-3

C8H8O3*C8H17NO2

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
In tetrahydrofuran; water at 0 - 55℃; for 5h;83%
(S)-3-[(dibenzylamino)methyl]-5-methylhexanoic acid

(S)-3-[(dibenzylamino)methyl]-5-methylhexanoic acid

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 3750.38 Torr; for 24h; Solvent; Pressure;82.7%
C13H25NO4

C13H25NO4

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With water; sodium hydroxide at 24℃; Reflux;81%
(S)-4-isobutyl-2-oxo-pyrrolidine-3-carboxylic acid

(S)-4-isobutyl-2-oxo-pyrrolidine-3-carboxylic acid

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
Stage #1: (S)-4-isobutyl-2-oxo-pyrrolidine-3-carboxylic acid With hydrogenchloride; water In ethyl acetate at 80 - 110℃; for 42 - 44h;
Stage #2: With potassium hydroxide In water pH=5.2 - 5.5;
80%
C13H24N2O2

C13H24N2O2

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With hydrogenchloride In water for 36h; Reflux;80%
C21H26N2O3

C21H26N2O3

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With perchloric acid; water for 12h; Reflux;79%
C16H29NO6

C16H29NO6

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With hydrogenchloride In water for 72h; Reflux;79%
C17H25NO4

C17H25NO4

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With water; potassium hydroxide In water for 20h; Reflux;78%
methyl (S)-3-cyano-5-methyl-hexanoate

methyl (S)-3-cyano-5-methyl-hexanoate

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
Stage #1: methyl (S)-3-cyano-5-methyl-hexanoate With water; potassium hydroxide In methanol at 20 - 25℃; for 1.5h;
Stage #2: With hydrogen In methanol at 30℃; under 7500.75 Torr; for 48h; Reagent/catalyst; Temperature; Time;
74.62%
Multi-step reaction with 2 steps
1: nickel dichloride; sodium tetrahydroborate; methanol
2: hydrogenchloride; water
View Scheme
(-)-(S)-3-(benzyloxycarbonylamino-methyl)-5-methyl-hexanoic acid
949890-75-9

(-)-(S)-3-(benzyloxycarbonylamino-methyl)-5-methyl-hexanoic acid

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 40℃; under 11251.1 Torr; for 10h; Solvent;68%
With hydrogen; palladium on activated charcoal In methanol at 20℃; under 7500.75 Torr; for 15h;60%
With palladium on activated charcoal; hydrogen In methanol at 20℃; under 11251.1 Torr; for 15h;60%
3-(azidomethyl)-5-methyl-hexanoic acid phenylmethyl ester
156048-97-4

3-(azidomethyl)-5-methyl-hexanoic acid phenylmethyl ester

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
With hydrogenchloride; palladium on activated charcoal In tetrahydrofuran; water at 20℃;65%
(1R)-1-({[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}oxy)ethyl 2-methylpropionate
1174524-47-0

(1R)-1-({[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}oxy)ethyl 2-methylpropionate

pregabilin
148553-50-8

pregabilin

3-{[(α-(R)-isobutanoyloxyethoxy)carbonyl]aminomethyl}-5-(S)-methylhexanoic acid
1174748-30-1

3-{[(α-(R)-isobutanoyloxyethoxy)carbonyl]aminomethyl}-5-(S)-methylhexanoic acid

Conditions
ConditionsYield
In water; acetonitrile at 20℃; for 16h;100%
(S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate
1174524-50-5

(S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate

pregabilin
148553-50-8

pregabilin

3-{[(α-(S)-isobutanoyloxyisobutoxy)carbonyl]aminomethyl}-5-(S)-methylhexanoic acid
1179336-90-3

3-{[(α-(S)-isobutanoyloxyisobutoxy)carbonyl]aminomethyl}-5-(S)-methylhexanoic acid

Conditions
ConditionsYield
In water; acetonitrile at 20℃; for 6h;100%
{[(1R)-Benzoyloxyethoxy]carbonyloxy}succinimide
1174524-53-8

{[(1R)-Benzoyloxyethoxy]carbonyloxy}succinimide

pregabilin
148553-50-8

pregabilin

(3S)-{[(1R)-benzoyloxyethoxy]carbonylaminomethyl}-5-methyl-hexanoic acid
1174748-47-0

(3S)-{[(1R)-benzoyloxyethoxy]carbonylaminomethyl}-5-methyl-hexanoic acid

Conditions
ConditionsYield
In water; acetonitrile at 20℃; for 16h;100%
lauric acid
143-07-7

lauric acid

pregabilin
148553-50-8

pregabilin

(S)-3-(aminomethyl)-5-methylhexanoic acid laurate
1414928-47-4

(S)-3-(aminomethyl)-5-methylhexanoic acid laurate

Conditions
ConditionsYield
In isopropyl alcohol for 1.5h; Product distribution / selectivity;100%
maleic acid
110-16-7

maleic acid

pregabilin
148553-50-8

pregabilin

(S)-3-(aminomethyl)-5-methylhexanoic acid maleate
1414928-41-8

(S)-3-(aminomethyl)-5-methylhexanoic acid maleate

Conditions
ConditionsYield
In 2-methylpropyl acetate for 0.75h; Product distribution / selectivity;100%
benzoic acid
65-85-0

benzoic acid

pregabilin
148553-50-8

pregabilin

(S)-3-(aminomethyl)-5-methylhexanoic acid benzoate
1414928-43-0

(S)-3-(aminomethyl)-5-methylhexanoic acid benzoate

Conditions
ConditionsYield
for 0.75h; Product distribution / selectivity;100%
Octanoic acid
124-07-2

Octanoic acid

pregabilin
148553-50-8

pregabilin

(S)-3-(aminomethyl)-5-methylhexanoic acid caprylate
1414928-45-2

(S)-3-(aminomethyl)-5-methylhexanoic acid caprylate

Conditions
ConditionsYield
In tert-butyl methyl ether for 0.75h;100%
1-decanoic acid
334-48-5

1-decanoic acid

pregabilin
148553-50-8

pregabilin

(S)-3-(aminomethyl)-5-methylhexanoic acid caprate
1414928-46-3

(S)-3-(aminomethyl)-5-methylhexanoic acid caprate

Conditions
ConditionsYield
In tert-butyl methyl ether for 0.75h;100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

pregabilin
148553-50-8

pregabilin

3-((tert-butoxycarbonylamino)methyl)-5-methylhexanoic acid
228104-41-4

3-((tert-butoxycarbonylamino)methyl)-5-methylhexanoic acid

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane; water98%
pregabilin
148553-50-8

pregabilin

(S)-4-isobutyl-pyrrolidin-2-one
181289-23-6

(S)-4-isobutyl-pyrrolidin-2-one

Conditions
ConditionsYield
With acidic kaolin In 5,5-dimethyl-1,3-cyclohexadiene for 6h; Solvent; Reagent/catalyst; Reflux;97%
With diazomethyl-trimethyl-silane In methanol; hexane for 0.5h;
at 80℃; for 336h; Kinetics; Temperature;
L-mandelate anion

L-mandelate anion

pregabilin
148553-50-8

pregabilin

(S)-Mandelic acid
17199-29-0

(S)-Mandelic acid

Conditions
ConditionsYield
With pyrographite In isopropyl alcohol at 0 - 85℃; for 4h;95%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

pregabilin
148553-50-8

pregabilin

(S)-3-(((tert-butoxycarbonyl)amino)methyl)-5-methylhexanoic acid
649748-09-4

(S)-3-(((tert-butoxycarbonyl)amino)methyl)-5-methylhexanoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water at 0℃; Inert atmosphere; Schlenk technique;93%
Stage #1: pregabilin With sodium hydroxide In 1,4-dioxane; water at 20℃; for 0.0833333h;
Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 20℃; for 1.5h;
86%
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;63%
L-proline hydrochloride
7776-34-3

L-proline hydrochloride

pregabilin
148553-50-8

pregabilin

(S)-3-(aminomethyl)-5-methylhexanoic acid L-proline hydrochloride
1414928-44-1

(S)-3-(aminomethyl)-5-methylhexanoic acid L-proline hydrochloride

Conditions
ConditionsYield
In acetonitrile at 20℃;93%
pregabilin
148553-50-8

pregabilin

4-(2-methylpropyl)pyrrolidin-2-one
61312-87-6

4-(2-methylpropyl)pyrrolidin-2-one

Conditions
ConditionsYield
at 190℃; for 0.166667h;91%
(E)-3-phenylpropenal
14371-10-9

(E)-3-phenylpropenal

pregabilin
148553-50-8

pregabilin

5-methyl-3-({(Z)-[(2E)-3-phenylprop-2-en-1-ylidene]amino}methyl)hexanoic acid

5-methyl-3-({(Z)-[(2E)-3-phenylprop-2-en-1-ylidene]amino}methyl)hexanoic acid

Conditions
ConditionsYield
With acetic acid In ethanol at 40℃; for 6h;90%
L-Tartaric acid
87-69-4

L-Tartaric acid

pregabilin
148553-50-8

pregabilin

(S)-3-(aminomethyl)-5-methylhexanoic acid L-(+)-tartrate
1190093-69-6

(S)-3-(aminomethyl)-5-methylhexanoic acid L-(+)-tartrate

Conditions
ConditionsYield
In water; isopropyl alcohol at 0 - 20℃; Product distribution / selectivity;89%
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