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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Rebamipide Manufacturer/High quality/Best price/In stock

Cas:90098-04-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High purity 99% factory priceRebamipide Powder

Cas:90098-04-7

Min.Order:1 Kilogram

FOB Price: $25.0 / 800.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Rebamipide supplier in China

Cas:90098-04-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Specifications MOQ1kg aceclofenac 1.packing:25kg/drum 2.delivery:within 7 days 3.place:hefei 4.GMP Analysis table ITEMS STANDARD

CAS:90098-04-7 Rebamipide

Cas:90098-04-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Rebamipide Cas 90098-04-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white crystaline powder Storage:-20°C Freezer Package:1kg/foil

Hot selling Rebamipide Cas 90098-04-7 with high quality and best price

Cas:90098-04-7

Min.Order:1 Kilogram

FOB Price: $290.0 / 303.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Rebamipide

Cas:90098-04-7

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Rebamipide 90098-04-7 GMP Manufacturer

Cas:90098-04-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Rebamipide -- CHemwill

Cas:90098-04-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Rebamipide

Cas:90098-04-7

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Rebamipide

Cas:90098-04-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 90098-04-7 with best quality

Cas:90098-04-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name Rebamipide CAS 90098-04-7 MF C19H15ClN2O4 MW 370.79 MP 288-290°C dec. Storage temp -20°C Freezer

Rebamipide

Cas:90098-04-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White crystalline powder Storage:R.T Package:25kg/Barrel Application:Used for stomach ulcers Transportation:Express/Sea/Air Port:Any port in China

Manufacture Rebamipide 99% powder in china

Cas:90098-04-7

Min.Order:1 Kilogram

FOB Price: $100.0 / 415.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

High Quality Pharmaceutical Raw Material Rebamipide 99% CAS 90098-04-7

Cas:90098-04-7

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Rebamipide 90098-04-7

Cas:90098-04-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antioxidant drugs Rebamipide with CAS:90098-04-7

Cas:90098-04-7

Min.Order:1 Kilogram

FOB Price: $86.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Rebamipide CAS 90098-04-7 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and

High quality Rebamipide CAS 90098-04-7

Cas:90098-04-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Rebamipide

Cas:90098-04-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Kemi-Works Chemical Co., Ltd

ProductName:Rebamipide Synonyms:RebamipideRebamipide CASNo.90098-04-7 MolecularFormula:C19H15ClN2O4 1.We have been specializing in special fine chemical for long, with strong R&D strength. 2.ISO9001. 3.We have been cooperating with

Rebamipide

Cas:90098-04-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Rebamipide manufacturer with low price

Cas:90098-04-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Rebamipide Powder

Cas:90098-04-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Rebamipide cas:90098-04-7

Cas:90098-04-7

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Rebamipide

Cas:90098-04-7

Min.Order:1 Kilogram

FOB Price: $300.0 / 500.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Rebamipide

Cas:90098-04-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

price, service, company and transport advantage: 1. best service, high quality and reasonable price. 2. it's customers' right to choose the package (ems, dhl, fedex, ups). 3. it's customers' right to choose the packing w

Rebamipide 90098-04-7 CAS NO.90098-04-7

Cas:90098-04-7

Min.Order:10 Metric Ton

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance: White Crystalline Powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Gastroduodenal ulcers Transportation:Common products:Sea/Air/Courier Dangerou

Rebamipide

Cas:90098-04-7

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Rebamipide

Cas:90098-04-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

we have GMP,it conforms to JP16 Appearance:White crystalline powder Storage:Room temperature Package:25kg/drum or as required Application:used in medicine Transportation:by sea by air express Port:China main port

Rebamipide made in china

Cas:90098-04-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Proamipide 90098-04-7

Cas:90098-04-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-amino-3-[2(1H)-quinolinone-4-yl]propionic acid dihydrochloride dihydrate

2-amino-3-[2(1H)-quinolinone-4-yl]propionic acid dihydrochloride dihydrate

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Stage #1: 2-amino-3-[2(1H)-quinolinone-4-yl]propionic acid dihydrochloride dihydrate; 4-chloro-benzoyl chloride With sodium hydroxide In water; acetone at 0℃;
Stage #2: With hydrogenchloride In water; acetone
96.9%
2-amino-3-[6-bromo-2(1H)-quinolon-4-yl]propionic acid
889573-80-2

2-amino-3-[6-bromo-2(1H)-quinolon-4-yl]propionic acid

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride
4876-14-6

2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Stage #1: 2-amino-3-[6-bromo-2(1H)-quinolon-4-yl]propionic acid; 2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride With sodium hydroxide; hydrogen; Raney nikel In water at 20℃; for 2h;
Stage #2: 4-chloro-benzoyl chloride With sodium hydroxide In water; acetone at 0℃;
Stage #3: With hydrogenchloride In water; acetone
96.2%
ethyl 2-(4-chlorobenzamido)-2-ethoxyoxo-3-[2-(1H)-quinolin-4-yl]propionate
1028268-32-7

ethyl 2-(4-chlorobenzamido)-2-ethoxyoxo-3-[2-(1H)-quinolin-4-yl]propionate

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol Reflux;94%
C20H16Cl2N2O3

C20H16Cl2N2O3

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
With ethanol; sodium hydroxide at 60 - 65℃; for 3h;93%
2(1H)-quinolinon-4-ylpropionic acid
71028-92-7

2(1H)-quinolinon-4-ylpropionic acid

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
With Lindlar's catalyst; ammonia In toluene at 90℃; under 375.038 Torr; for 2h; Reagent/catalyst; Inert atmosphere; Autoclave; Green chemistry;89%
4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

2‐amino‐3‐[2(1H)‐quinolinon‐4‐yl]propionic acid
5162-90-3

2‐amino‐3‐[2(1H)‐quinolinon‐4‐yl]propionic acid

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
With sodium hydroxide In water at 0 - 20℃; for 18h; Inert atmosphere;59%
With potassium hydroxide In tetrahydrofuran; water at 0 - 15℃; for 2.5h; Reagent/catalyst; Solvent; Temperature;
4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride
4876-14-6

2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
With potassium carbonate In water; acetone for 2h;49%
4-bromomethyl-2(1H)-quinolinone
4876-10-2

4-bromomethyl-2(1H)-quinolinone

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 69 percent / sodium / ethanol / 2 h
2: 89 percent / 20 percent hydrochloric acid / 9 h / Heating
3: 49 percent / K2CO3 / acetone; H2O / 2 h
View Scheme
Multi-step reaction with 5 steps
1.1: magnesium; methyl iodide / tetrahydrofuran; 1,4-dioxane / 10 h / 80 °C / Inert atmosphere; Green chemistry
1.2: 5 h / 70 °C / Inert atmosphere; Green chemistry
2.1: sulfuric acid; potassium hydroxide / Green chemistry
3.1: thionyl chloride / pyridine / 6 h / 70 °C / Inert atmosphere; Green chemistry
4.1: sodium carbonate / 72 h / 50 - 70 °C / Green chemistry
5.1: sulfuric acid / 3 h / 80 °C / Green chemistry
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / dimethyl sulfoxide; water / 2 h / 20 - 30 °C / Large scale
2: hydrogenchloride; acetic acid / water / 7 h / 130 - 140 °C / Large scale
3: sodium hydroxide / water / 0.5 h / 0 - 10 °C / Large scale
View Scheme
2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester
4900-38-3

2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / 20 percent hydrochloric acid / 9 h / Heating
2: 49 percent / K2CO3 / acetone; H2O / 2 h
View Scheme
ethanol
64-17-5

ethanol

4-bromomethyl-2(1H)-quinolinone
4876-10-2

4-bromomethyl-2(1H)-quinolinone

diethyl (((4-chlorophenyl)carbonyl)amino)propanedioate
81918-01-6

diethyl (((4-chlorophenyl)carbonyl)amino)propanedioate

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; sodium ethanolate In water7.18 g (92.17%)
With hydrogenchloride; potassium hydroxide; sodium ethanolate7.17 g (92.04%)
With hydrogenchloride; potassium hydroxide; sodium ethanolate In water7.08 g (90.88%)
With hydrogenchloride; sodium hydroxide; sodium ethanolate7.15 g (91.78%)
With hydrogenchloride; sodium hydroxide; sodium ethanolate In water6.7 g (86.0%)
4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / chloroform / 0.5 h / 20 °C
1.2: 2 h / 5 - 20 °C
2.1: sodium ethanolate; sodium / ethanol / 1.5 h / 20 °C
2.2: 20 °C
3.1: water; sodium hydroxide / ethanol / Reflux
View Scheme
Multi-step reaction with 3 steps
1: ammonium hydroxide / 4.5 h / 30 °C / Large scale; Green chemistry
2: sodium carbonate / 72 h / 50 - 70 °C / Green chemistry
3: sulfuric acid / 3 h / 80 °C / Green chemistry
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 4 h / 0 - 25 °C
2: phosphorus pentachloride / toluene / 3 h / 80 °C
3: triethylamine / toluene / 5 h / 70 - 80 °C
4: sodium hydroxide; ethanol / 3 h / 60 - 65 °C
View Scheme
C12H10N2O2

C12H10N2O2

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: thionyl chloride / pyridine / 6 h / 70 °C / Inert atmosphere; Green chemistry
2: sodium carbonate / 72 h / 50 - 70 °C / Green chemistry
3: sulfuric acid / 3 h / 80 °C / Green chemistry
View Scheme
C19H14ClN3O2

C19H14ClN3O2

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
With sulfuric acid at 80℃; for 3h; Green chemistry;
C11H9NO2

C11H9NO2

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid; potassium hydroxide / Green chemistry
2: thionyl chloride / pyridine / 6 h / 70 °C / Inert atmosphere; Green chemistry
3: sodium carbonate / 72 h / 50 - 70 °C / Green chemistry
4: sulfuric acid / 3 h / 80 °C / Green chemistry
View Scheme
2-amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid dihydrochloride

2-amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid dihydrochloride

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
With sodium hydroxide In water at 0 - 10℃; for 0.5h; Large scale;6.85 kg
3,3-Dimethoxy-N-phenylpropanamide
122347-19-7

3,3-Dimethoxy-N-phenylpropanamide

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid / dichloromethane / 2 h / 0 - 60 °C / Green chemistry
2: Lindlar's catalyst; ammonia / toluene / 2 h / 90 °C / 375.04 Torr / Inert atmosphere; Autoclave; Green chemistry
View Scheme
N-(benzyloxycarbonyl)aniline
3422-02-4

N-(benzyloxycarbonyl)aniline

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide; 5%-palladium/activated carbon; hydrogen / methanol / 2 h / 20 °C / 750.08 Torr / Autoclave; Green chemistry
2: lithium diisopropyl amide / tetrahydrofuran / 5.5 h / 0 - 25 °C / Green chemistry
3: sulfuric acid / dichloromethane / 2 h / 0 - 60 °C / Green chemistry
4: Lindlar's catalyst; ammonia / toluene / 2 h / 90 °C / 375.04 Torr / Inert atmosphere; Autoclave; Green chemistry
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide; 5%-palladium/activated carbon; hydrogen / methanol / 2 h / 20 °C / 750.08 Torr / Autoclave; Green chemistry
2: lithium diisopropyl amide / tetrahydrofuran / 5.5 h / 0 - 25 °C / Green chemistry
3: sulfuric acid / dichloromethane / 2 h / 0 - 60 °C / Green chemistry
4: Lindlar's catalyst; ammonia / toluene / 2 h / 90 °C / 375.04 Torr / Inert atmosphere; Autoclave; Green chemistry
View Scheme
benzoic acid
65-85-0

benzoic acid

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 1 h / 80 - 100 °C / Green chemistry
1.2: 3 h / 10 - 20 °C / Green chemistry
1.3: Green chemistry
2.1: sodium hydroxide; 5%-palladium/activated carbon; hydrogen / methanol / 2 h / 20 °C / 750.08 Torr / Autoclave; Green chemistry
3.1: lithium diisopropyl amide / tetrahydrofuran / 5.5 h / 0 - 25 °C / Green chemistry
4.1: sulfuric acid / dichloromethane / 2 h / 0 - 60 °C / Green chemistry
5.1: Lindlar's catalyst; ammonia / toluene / 2 h / 90 °C / 375.04 Torr / Inert atmosphere; Autoclave; Green chemistry
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 1 h / 80 - 100 °C / Green chemistry
1.2: 3 h / 10 - 20 °C / Green chemistry
1.3: Green chemistry
2.1: sodium hydroxide; 5%-palladium/activated carbon; hydrogen / methanol / 2 h / 20 °C / 750.08 Torr / Autoclave; Green chemistry
3.1: lithium diisopropyl amide / tetrahydrofuran / 5.5 h / 0 - 25 °C / Green chemistry
4.1: sulfuric acid / dichloromethane / 2 h / 0 - 60 °C / Green chemistry
5.1: Lindlar's catalyst; ammonia / toluene / 2 h / 90 °C / 375.04 Torr / Inert atmosphere; Autoclave; Green chemistry
View Scheme
aniline
62-53-3

aniline

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium diisopropyl amide / tetrahydrofuran / 5.5 h / 0 - 25 °C / Green chemistry
2: sulfuric acid / dichloromethane / 2 h / 0 - 60 °C / Green chemistry
3: Lindlar's catalyst; ammonia / toluene / 2 h / 90 °C / 375.04 Torr / Inert atmosphere; Autoclave; Green chemistry
View Scheme
Multi-step reaction with 3 steps
1: lithium diisopropyl amide / tetrahydrofuran / 5.5 h / 0 - 25 °C / Green chemistry
2: sulfuric acid / dichloromethane / 2 h / 0 - 60 °C / Green chemistry
3: Lindlar's catalyst; ammonia / toluene / 2 h / 90 °C / 375.04 Torr / Inert atmosphere; Autoclave; Green chemistry
View Scheme
N-(p-chlorobenzoyl)-glycine methyl ester
59893-99-1

N-(p-chlorobenzoyl)-glycine methyl ester

rebamipide
90098-04-7

rebamipide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / toluene / 3 h / 80 °C
2: triethylamine / toluene / 5 h / 70 - 80 °C
3: sodium hydroxide; ethanol / 3 h / 60 - 65 °C
View Scheme
rebamipide
90098-04-7

rebamipide

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid tris(hydroxymethyl)aminomethane salt
861243-12-1

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid tris(hydroxymethyl)aminomethane salt

Conditions
ConditionsYield
Stage #1: rebamipide; 2-amino-2-hydroxymethyl-1,3-propanediol In ethanol for 0.5h; Heating / reflux;
Stage #2: In ethanol; water Heating / reflux;
97%
L-arginine
74-79-3

L-arginine

rebamipide
90098-04-7

rebamipide

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid L-arginine salt
861243-10-9

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid L-arginine salt

Conditions
ConditionsYield
Stage #1: L-arginine; rebamipide In ethanol for 0.5h; Heating / reflux;
Stage #2: In ethanol; water Heating / reflux;
95%
rebamipide
90098-04-7

rebamipide

ethylenediamine
107-15-3

ethylenediamine

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid 1/2 ethylenediamine salt

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid 1/2 ethylenediamine salt

Conditions
ConditionsYield
Stage #1: rebamipide; ethylenediamine In ethanol for 0.5h; Heating / reflux;
Stage #2: In ethanol; water Product distribution / selectivity; Heating / reflux;
89%
methanol
67-56-1

methanol

rebamipide
90098-04-7

rebamipide

C19H15ClN2O4*CH4O

C19H15ClN2O4*CH4O

Conditions
ConditionsYield
at 120℃; for 48h; Autoclave;82%
ethanol
64-17-5

ethanol

rebamipide
90098-04-7

rebamipide

C19H14ClN2O4(1-)*Na(1+)*C2H6O

C19H14ClN2O4(1-)*Na(1+)*C2H6O

Conditions
ConditionsYield
With sodium hydroxide at 20℃;80%
rebamipide
90098-04-7

rebamipide

2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid diethanolamine salt
861243-13-2

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid diethanolamine salt

Conditions
ConditionsYield
In ethanol for 0.5h; Heating / reflux;76%
rebamipide
90098-04-7

rebamipide

C19H13ClN2O4(2-)*2Na(1+)*4H2O

C19H13ClN2O4(2-)*2Na(1+)*4H2O

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 20℃;75%
methanol
67-56-1

methanol

rebamipide
90098-04-7

rebamipide

methyl 2-(4-chlorobenzoylamino)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionate
90098-38-7

methyl 2-(4-chlorobenzoylamino)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionate

Conditions
ConditionsYield
In water at 120℃; for 48h; Autoclave;75%
rebamipide
90098-04-7

rebamipide

diisopropanolamine
110-97-4

diisopropanolamine

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid diisopropanolamine salt

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid diisopropanolamine salt

Conditions
ConditionsYield
In ethanol for 0.5h; Heating / reflux;61%
1-deoxy-1-(methylamino)-D-glucitol
6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

rebamipide
90098-04-7

rebamipide

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid meglumine salt
861243-15-4

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid meglumine salt

Conditions
ConditionsYield
Stage #1: 1-deoxy-1-(methylamino)-D-glucitol; rebamipide In water at 50℃;
Stage #2: 1-deoxy-1-(methylamino)-D-glucitol With hydrogenchloride In water
61%
L-lysine
56-87-1

L-lysine

rebamipide
90098-04-7

rebamipide

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid L-lysine salt
847165-02-0

2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid L-lysine salt

Conditions
ConditionsYield
Stage #1: L-lysine; rebamipide In ethanol for 0.5h; Heating / reflux;
Stage #2: In ethanol; water Heating / reflux;
54%
rebamipide
90098-04-7

rebamipide

3-((2-(4-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoyl)oxy)propane-1,2-diyl dibutyrate

3-((2-(4-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoyl)oxy)propane-1,2-diyl dibutyrate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide at 0 - 20℃; Inert atmosphere;2.2%
nicotinamide
98-92-0

nicotinamide

rebamipide
90098-04-7

rebamipide

rebamipide nicotinamide

rebamipide nicotinamide

Conditions
ConditionsYield
In nitromethane for 120h; Sealed vial;
4-hydroxysalicylic acid
89-86-1

4-hydroxysalicylic acid

rebamipide
90098-04-7

rebamipide

rebamipide 2,4-dihydroxybenzoic acid

rebamipide 2,4-dihydroxybenzoic acid

Conditions
ConditionsYield
In nitromethane for 120h; Sealed vial;
3-azidopropylamine
88192-19-2

3-azidopropylamine

rebamipide
90098-04-7

rebamipide

C22H21ClN6O3

C22H21ClN6O3

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In dichloromethane
rebamipide
90098-04-7

rebamipide

cyclohexylmethyl alcohol
100-49-2

cyclohexylmethyl alcohol

cyclohexylmethyl 2-(4-chlorobenzoylamino)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionate

cyclohexylmethyl 2-(4-chlorobenzoylamino)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionate

Conditions
ConditionsYield
With inorganic salt In N,N-dimethyl-formamide at 20 - 80℃;0.7 g
rebamipide
90098-04-7

rebamipide

i-pentyl bromide
107-82-4

i-pentyl bromide

3-methylbutyl 2-(4-chlorobenzoylamino)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionate

3-methylbutyl 2-(4-chlorobenzoylamino)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionate

Conditions
ConditionsYield
With inorganic salt In N,N-dimethyl-formamide at 20 - 80℃;0.7 g
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