Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008, production and quality managemen
Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:1188-21-2
Min.Order:25 Kilogram
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Type:Trading Company
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:1188-21-2
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryProduct description: Product name N-Acetyl-L-leucine CAS number 1188-21-2 Assay ≥99% Appearance White powder Capacity 200mt/year Application Pharmaceutical intermediates
Cas:1188-21-2
Min.Order:100 Gram
FOB Price: $12.0
Type:Lab/Research institutions
inquiryManufacturer supply N-Acetyl-L-leucine CAS 1188-21-2 with best price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed
Cas:1188-21-2
Min.Order:1 Kilogram
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Type:Trading Company
inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:1188-21-2
Min.Order:1 Gram
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Type:Manufacturers
inquiryThe area of Chengdu Baishixing is 35,000 square metre , the staff members are 88, our output value is over 120 millions per year. Baishiying cooporates with Life Science Academy of Wuhan University to develop amino acids series products.We ha
Zorui combines R&D, production and sales into its operations, While continuously providing high-quality raw materials, we also provide and optimize technical solutions for customers to achieve mutual benefit. We adhere to the "quality, integ
Cas:1188-21-2
Min.Order:1 Kilogram
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
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Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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Min.Order:5 Kiloliter
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Type:Manufacturers
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Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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Min.Order:10 Gram
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Type:Trading Company
inquiryProduct name N-Acetyl-L-leucine Cas No 1188-21-2 Appearance White powder Assay 99% Application organic intermediat
Cas:1188-21-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
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Cas:1188-21-2
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers
Cas:1188-21-2
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:1188-21-2
Min.Order:10 Gram
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Type:Trading Company
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Cas:1188-21-2
Min.Order:1 Kilogram
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Type:Trading Company
inquiryN-Acetyl-L-leucine CAS: 1188-21-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm
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Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
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Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe
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Min.Order:1 Kilogram
FOB Price: $20.0 / 40.0
Type:Trading Company
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:1188-21-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Overview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie
Cas:1188-21-2
Min.Order:100 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryPrice, service, company and transport advantage: 1.place of origin china with super quality by reasonable price. 2. it's customers' right to choose the package (ems, dhl, fedex, ups); 3. it's custo
Cas:1188-21-2
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryAppearance:white crystalline powder Storage:Sealed in dry,Room Temperature Application:N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of
Cas:1188-21-2
Min.Order:25 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid
N-Ac-Leu
Conditions | Yield |
---|---|
With hydrogen; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; triethylamine; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane In tetrahydrofuran at 20℃; under 750.075 Torr; for 24h; | 100% |
With hydrogen; Rh(I)-(S)-chairphos In tetrahydrofuran Product distribution; Ambient temperature; other catalyst; other solvents; influence on products' optical yields; | |
With hydrogen; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine); [rhodium(I)(norborna-2,5-diene)2]SbF6 In dichloromethane at 20℃; under 1292.87 Torr; for 24h; | |
With chiral (1,1'-ferrocenediyl)bis(phospholo[3,4-d][1,3]dioxole); hydrogen; bis(1,5-cyclooctadiene)rhodium(I) hexafluorophosphate In tetrahydrofuran at 20℃; under 775.743 Torr; for 1h; |
Conditions | Yield |
---|---|
In water for 0.0666667h; Irradiation; | 98% |
With sodium hydrogencarbonate In water at 0 - 20℃; for 5h; | 89% |
With triethylamine In water at 20℃; | 35% |
methyl N-acetyl-leucinate
A
N-Ac-Leu
B
methyl (R)-2-(N-acetylamino)-4-methylpentanoate
Conditions | Yield |
---|---|
With sodium hydroxide; phosphate buffer; pronase EC 3.4.24.4 In tetrahydrofuran Ambient temperature; | A 79% B 91% |
Conditions | Yield |
---|---|
at 0 - 20℃; | 89% |
(S)-benzyl 2-acetamido-4-methylpentanoate
N-Ac-Leu
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h; | 81% |
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h; | 81% |
Conditions | Yield |
---|---|
With sodium hydroxide |
Conditions | Yield |
---|---|
With (-)-α-fenchylamine |
methyl N-acetyl-leucinate
N-Ac-Leu
Conditions | Yield |
---|---|
for 118h; carbonate hydrolyase EC 4.2.2.1 (bovine carbonic anhydrase, BCA), pH 7.5; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
In ethanol; water at 35℃; for 48h; Yield given; |
2-acetylamino-4-methyl-pent-2-enoic acid
N-Ac-Leu
Conditions | Yield |
---|---|
With hydrogen; <(2R,3R)-2,3-Bis(diphenylphosphino)butan>(ϖ-norbornadien)rhodium(I)-perchlorate In tetrahydrofuran under 3000.2 Torr; for 8h; Yield given; |
2-acetylamino-4-methyl-pent-2-enoic acid
A
N-Ac-Leu
B
N-acetyl-D-leucine
Conditions | Yield |
---|---|
With hydrogen; ClO4; (2R,3S)-1,2-bis(diphenylphosphino)-3-tBoc-aminobutane In ethanol for 22h; Ambient temperature; Yield given; | |
With ; hydrogen In ethanol at 20℃; under 760 Torr; Title compound not separated from byproducts; |
(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid
A
N-Ac-Leu
B
N-acetyl-D-leucine
Conditions | Yield |
---|---|
With <(1R;2R-MAC-PONP)Rh(COD)>(+)BF4(-); hydrogen In methanol at 30℃; under 750.06 Torr; Title compound not separated from byproducts; | |
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; triethylamine; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane In tetrahydrofuran under 760 Torr; for 24h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With hydrogen; triethylamine; ClO4; (2S,4S)-MOD-BPPM In ethanol at 50℃; under 15200 Torr; for 20h; Title compound not separated from byproducts; |
(1'S,3S)-8-acetoxy-3-<1'-(acetylamino)-3'-methylbutyl>-3,4-dihydro-1-oxo-1H-2-benzopyran
N-Ac-Leu
Conditions | Yield |
---|---|
With potassium permanganate; magnesium sulfate In water for 1.5h; Heating; |
Conditions | Yield |
---|---|
β‐cyclodextrin In water; dimethyl sulfoxide at 25℃; Rate constant; Mechanism; various conditions; |
Conditions | Yield |
---|---|
With rice bran lipase; sodium chloride at 30℃; pH=7.5; Title compound not separated from byproducts; |
acetamide
carbon monoxide
isovaleraldehyde
A
N-Ac-Leu
B
N-acetyl-D-leucine
Conditions | Yield |
---|---|
With sulfuric acid; lithium bromide; bis(triphenylphosphine)palladium dibromide In various solvent(s) at 120℃; under 45003.6 Torr; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
DL-leucine methyl ester
N-Ac-Leu
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaOCH3 / Brenner esterification 2: pyridine 3: H2O; ethanol / 48 h / 35 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine 2: H2O; ethanol / 48 h / 35 °C View Scheme |
(3S)-3-<(1'S)-1'-amino-3'-methylbutyl>-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one
N-Ac-Leu
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / pyridine / 2 h / 50 °C 2: KMnO4, MgSO4 / H2O / 1.5 h / Heating View Scheme |
C8H13NO3
N-Ac-Leu
Conditions | Yield |
---|---|
With {Rh[ZhangPhos](nbd)}BF4; hydrogen In methanol at 20℃; under 1034.32 Torr; for 12h; optical yield given as %ee; enantioselective reaction; |
Conditions | Yield |
---|---|
With potassium carbonate In 1,4-dioxane; water |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 50 °C View Scheme |
(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
N-Ac-Leu
(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
Conditions | Yield |
---|---|
In methanol for 1h; Reflux; | 98.3% |
In methanol at 65 - 70℃; | |
In methanol for 1h; Reflux; | 1670 g |
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
N-Ac-Leu
Conditions | Yield |
---|---|
In methanol at 20℃; for 4h; Reflux; | 98% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 4.5h; | 98% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 8h; | 96% |
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 0 - 20℃; for 4.5h; | 96% |
N-Ac-Leu
(4R,5S)-1,5-Dimethyl-3-((2R,3S)-3-methyl-aziridine-2-carbonyl)-4-phenyl-imidazolidin-2-one
N-{(S)-1-[(2R,3S)-2-((4S,5R)-3,4-Dimethyl-2-oxo-5-phenyl-imidazolidine-1-carbonyl)-3-methyl-aziridine-1-carbonyl]-3-methyl-butyl}-acetamide
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane; acetonitrile for 12h; Ambient temperature; | 95% |
N-Ac-Leu
benzyl (R)-aziridine-2-carboxylate
benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 6h; Acylation; | 95% |
N-Ac-Leu
(4R,5S,2'R)-1,5-dimethyl-3-[(2'-aziridinyl)carbonyl]-4-phenylimidazolidin-2-one
(4R,5S,2'R,2''S)-1,5-dimethyl-3-{[1'-(2''-acetamido-4''-methylpentanoyl)-2'-aziridinyl]carbonyl}-4-phenylimidazolidin-2-one
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 6h; Acylation; | 95% |
Conditions | Yield |
---|---|
Stage #1: N-Ac-Leu With caesium carbonate In acetonitrile at 20℃; for 0.333333h; Stage #2: 2,2,2-trifluoroethyl trifluoromethanesulphonate In acetonitrile at 20℃; for 3h; | 94% |
Conditions | Yield |
---|---|
With K10 clay for 0.0333333h; Cyclization; microwave irradiation; | 93% |
With diethyldichlorosilane Heating; | 60% |
With toluene-4-sulfonic acid In benzene Heating; | |
With toluene-4-sulfonic acid In toluene |
[(S)-1-((S)-1-{(S)-[(2R,3S)-2-((S)-1-Butylcarbamoyl-2-methyl-propylcarbamoyl)-tetrahydro-furan-3-yl]-hydroxy-methyl}-3-methyl-butylcarbamoyl)-3-methylsulfanyl-propyl]-carbamic acid tert-butyl ester
N-Ac-Leu
Conditions | Yield |
---|---|
With hydrogenchloride In various solvents at 0 - 5℃; | 92% |
Conditions | Yield |
---|---|
Solid phase reaction; | 90% |
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
N-Ac-Leu
(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
Conditions | Yield |
---|---|
In methanol at 20℃; for 8h; Reflux; Resolution of racemate; | 90% |
Stage #1: 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine; N-Ac-Leu In methanol for 1h; Reflux; Stage #2: In methanol at 20℃; for 4h; Reflux; | 90% |
In methanol at 20℃; for 4h; Reflux; | 90% |
Conditions | Yield |
---|---|
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.; | 90% |
Conditions | Yield |
---|---|
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.; | 90% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide | 89% |
Stage #1: N-Ac-Leu With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 24h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 25℃; for 24h; |
N-Ac-Leu
N-methylglycine methyl ester hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-Ac-Leu With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h; Stage #2: N-methylglycine methyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; | 89% |
Conditions | Yield |
---|---|
With thionyl chloride at 0℃; for 4h; | 88% |
Conditions | Yield |
---|---|
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.; | 87% |
N-Ac-Leu
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In acetonitrile at 20℃; for 2h; Inert atmosphere; | 87% |
Conditions | Yield |
---|---|
Stage #1: C12H14(2)H3NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h; Stage #2: N-Ac-Leu In methanol at 20 - 55℃; | 86% |
N-Ac-Leu
Conditions | Yield |
---|---|
With potassium carbonate; sodium iodide In acetone at 70℃; for 1h; | 86% |
1-hydroxy-pyrrolidine-2,5-dione
N-Ac-Leu
N-acetyl-L-leucine N-hydroxysuccinimide ester
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; | 85% |
Conditions | Yield |
---|---|
Stage #1: C12H14(2)H3NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In methanol; 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h; Stage #2: N-Ac-Leu In methanol at 20 - 55℃; | 85% |
Conditions | Yield |
---|---|
Stage #1: C12H10(2)H7NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h; Stage #2: N-Ac-Leu In methanol at 20 - 55℃; for 1h; | 85% |
Conditions | Yield |
---|---|
Stage #1: C12H5(2)H12NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h; Stage #2: N-Ac-Leu In methanol at 55℃; for 1h; | 85% |
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