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SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008, production and quality managemen

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up Ac-Leu-OH N-Acetyl-L-leucine 1188-21-2

Cas:1188-21-2

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality N-Acetyl-L-Leucine supplier in China

Cas:1188-21-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name N-Acetyl-L-leucine CAS number 1188-21-2 Assay ≥99% Appearance White powder Capacity 200mt/year Application Pharmaceutical intermediates

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:100 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Manufacturer supply N-Acetyl-L-leucine CAS 1188-21-2 with best price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed

Manufacturer supply N-Acetyl-L-leucine CAS 1188-21-2 with best price

Cas:1188-21-2

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply N-Acetyl-L-Leucine

Cas:1188-21-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Food Grade N-Acetyl-L-Leucine 1188-21-2 HACCP Manufacturer

Cas:1188-21-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chengdu Baishixing Science and Technology Industry Co., Ltd.

The area of Chengdu Baishixing is 35,000 square metre , the staff members are 88, our output value is over 120 millions per year. Baishiying cooporates with Life Science Academy of Wuhan University to develop amino acids series products.We ha

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:25 Kilogram

Negotiable

Type:Manufacturers

inquiry

Shanxi Zorui Biotechnology Co.Ltd.

Zorui combines R&D, production and sales into its operations, While continuously providing high-quality raw materials, we also provide and optimize technical solutions for customers to achieve mutual benefit. We adhere to the "quality, integ

N-Acetyl-L-Leucine Amino Acid Powder CAS 1188-21-2

Cas:1188-21-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

N-Acetyl-L-Leucine

Cas:1188-21-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:1 Kilogram

FOB Price: $8.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

N-Acetyl-L-Leucine

Cas:1188-21-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

N-Acetyl-L-leucine CAS 1188-21-2

Cas:1188-21-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New Standard CAS 1188-21-2 with fast shipping

Cas:1188-21-2

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name N-Acetyl-L-leucine Cas No 1188-21-2 Appearance White powder Assay 99% Application organic intermediat

N-Acetyl-L-leucine CAS:1188-21-2

Cas:1188-21-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

N-acetyl-L-leucine manufacturer/supplier

Cas:1188-21-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

Cosmetic Peptide(16) N-Acetyl-L-Leucine Model:CAS:1188-21-2

Cas:1188-21-2

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

N-Acetyl-L-leucine 1188-21-2

Cas:1188-21-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:1 Kilogram

FOB Price: $35.0 / 40.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

N-Acetyl-L-leucine CAS: 1188-21-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm

N-Acetyl-L-leucine CAS: 1188-21-2

Cas:1188-21-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe

N-acetyl-L-leucine CAS 1188-21-2

Cas:1188-21-2

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

Overview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie

China Biggest Factory & Manufacturer supply N-Acetyl-L-leucine 500MT/Year

Cas:1188-21-2

Min.Order:100 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Price, service, company and transport advantage: 1.place of origin china with super quality by reasonable price. 2. it's customers' right to choose the package (ems, dhl, fedex, ups); 3. it's custo

BEST PRICE/N-Acetyl-L-Leucine

Cas:1188-21-2

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white crystalline powder Storage:Sealed in dry,Room Temperature Application:N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of

N-Acetyl-L-leucine

Cas:1188-21-2

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid
64896-30-6

(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With hydrogen; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; triethylamine; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane In tetrahydrofuran at 20℃; under 750.075 Torr; for 24h;100%
With hydrogen; Rh(I)-(S)-chairphos In tetrahydrofuran Product distribution; Ambient temperature; other catalyst; other solvents; influence on products' optical yields;
With hydrogen; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine); [rhodium(I)(norborna-2,5-diene)2]SbF6 In dichloromethane at 20℃; under 1292.87 Torr; for 24h;
With chiral (1,1'-ferrocenediyl)bis(phospholo[3,4-d][1,3]dioxole); hydrogen; bis(1,5-cyclooctadiene)rhodium(I) hexafluorophosphate In tetrahydrofuran at 20℃; under 775.743 Torr; for 1h;
L-leucine
61-90-5

L-leucine

acetic anhydride
108-24-7

acetic anhydride

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
In water for 0.0666667h; Irradiation;98%
With sodium hydrogencarbonate In water at 0 - 20℃; for 5h;89%
With triethylamine In water at 20℃;35%
methyl N-acetyl-leucinate
57289-25-5

methyl N-acetyl-leucinate

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

methyl (R)-2-(N-acetylamino)-4-methylpentanoate
35799-87-2

methyl (R)-2-(N-acetylamino)-4-methylpentanoate

Conditions
ConditionsYield
With sodium hydroxide; phosphate buffer; pronase EC 3.4.24.4 In tetrahydrofuran Ambient temperature;A 79%
B 91%
L-Norvaline
6600-40-4

L-Norvaline

acetic anhydride
108-24-7

acetic anhydride

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
at 0 - 20℃;89%
(S)-benzyl 2-acetamido-4-methylpentanoate
244250-56-4

(S)-benzyl 2-acetamido-4-methylpentanoate

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h;81%
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h;81%
Ketene
463-51-4

Ketene

L-leucine
61-90-5

L-leucine

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With sodium hydroxide
N-acetylleucine
99-15-0

N-acetylleucine

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With (-)-α-fenchylamine
methyl N-acetyl-leucinate
57289-25-5

methyl N-acetyl-leucinate

N-Ac-Leu
1188-21-2

N-Ac-Leu

methyl N-acetyl-leucinate
57289-25-5

methyl N-acetyl-leucinate

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
for 118h; carbonate hydrolyase EC 4.2.2.1 (bovine carbonic anhydrase, BCA), pH 7.5; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
ethyl N-acetyl-leucinate
4071-36-7

ethyl N-acetyl-leucinate

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-O-ethyl-D-leucine
75552-78-2

N-acetyl-O-ethyl-D-leucine

Conditions
ConditionsYield
In ethanol; water at 35℃; for 48h; Yield given;
2-acetylamino-4-methyl-pent-2-enoic acid
915008-30-9

2-acetylamino-4-methyl-pent-2-enoic acid

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With hydrogen; <(2R,3R)-2,3-Bis(diphenylphosphino)butan>(ϖ-norbornadien)rhodium(I)-perchlorate In tetrahydrofuran under 3000.2 Torr; for 8h; Yield given;
2-acetylamino-4-methyl-pent-2-enoic acid
915008-30-9

2-acetylamino-4-methyl-pent-2-enoic acid

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With hydrogen; ClO4; (2R,3S)-1,2-bis(diphenylphosphino)-3-tBoc-aminobutane In ethanol for 22h; Ambient temperature; Yield given;
With ; hydrogen In ethanol at 20℃; under 760 Torr; Title compound not separated from byproducts;
(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid
64896-30-6

(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With <(1R;2R-MAC-PONP)Rh(COD)>(+)BF4(-); hydrogen In methanol at 30℃; under 750.06 Torr; Title compound not separated from byproducts;
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; triethylamine; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane In tetrahydrofuran under 760 Torr; for 24h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With hydrogen; triethylamine; ClO4; (2S,4S)-MOD-BPPM In ethanol at 50℃; under 15200 Torr; for 20h; Title compound not separated from byproducts;
(1'S,3S)-8-acetoxy-3-<1'-(acetylamino)-3'-methylbutyl>-3,4-dihydro-1-oxo-1H-2-benzopyran
85785-66-6

(1'S,3S)-8-acetoxy-3-<1'-(acetylamino)-3'-methylbutyl>-3,4-dihydro-1-oxo-1H-2-benzopyran

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With potassium permanganate; magnesium sulfate In water for 1.5h; Heating;
L-leucine
61-90-5

L-leucine

4-nitrophenol acetate
830-03-5

4-nitrophenol acetate

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
β‐cyclodextrin In water; dimethyl sulfoxide at 25℃; Rate constant; Mechanism; various conditions;
N-acetyl-DL-isoleucine butyl ester
2256-97-5

N-acetyl-DL-isoleucine butyl ester

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With rice bran lipase; sodium chloride at 30℃; pH=7.5; Title compound not separated from byproducts;
acetamide
60-35-5

acetamide

carbon monoxide
201230-82-2

carbon monoxide

isovaleraldehyde
590-86-3

isovaleraldehyde

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With sulfuric acid; lithium bromide; bis(triphenylphosphine)palladium dibromide In various solvent(s) at 120℃; under 45003.6 Torr; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
Ketene
463-51-4

Ketene

L-leucine
61-90-5

L-leucine

alkali

alkali

N-Ac-Leu
1188-21-2

N-Ac-Leu

DL-leucine methyl ester
18869-43-7

DL-leucine methyl ester

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaOCH3 / Brenner esterification
2: pyridine
3: H2O; ethanol / 48 h / 35 °C
View Scheme
DL-leucine ethyl ester
2899-43-6

DL-leucine ethyl ester

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: H2O; ethanol / 48 h / 35 °C
View Scheme
(3S)-3-<(1'S)-1'-amino-3'-methylbutyl>-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one
57765-73-8

(3S)-3-<(1'S)-1'-amino-3'-methylbutyl>-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / pyridine / 2 h / 50 °C
2: KMnO4, MgSO4 / H2O / 1.5 h / Heating
View Scheme
C8H13NO3
74839-85-3

C8H13NO3

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With {Rh[ZhangPhos](nbd)}BF4; hydrogen In methanol at 20℃; under 1034.32 Torr; for 12h; optical yield given as %ee; enantioselective reaction;
L-leucine
61-90-5

L-leucine

acetyl chloride
75-36-5

acetyl chloride

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With potassium carbonate In 1,4-dioxane; water
L-leucine benzyl ester p-toluenesulfonate
1738-77-8

L-leucine benzyl ester p-toluenesulfonate

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 50 °C
View Scheme
(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
608141-42-0

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

N-Ac-Leu
1188-21-2

N-Ac-Leu

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
608141-43-1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

Conditions
ConditionsYield
In methanol for 1h; Reflux;98.3%
In methanol at 65 - 70℃;
In methanol for 1h; Reflux;1670 g
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
253168-94-4

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

N-Ac-Leu
1188-21-2

N-Ac-Leu

1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-ethylamine N-acetyl-L-leucine salt

1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-ethylamine N-acetyl-L-leucine salt

Conditions
ConditionsYield
In methanol at 20℃; for 4h; Reflux;98%
N-Ac-Leu
1188-21-2

N-Ac-Leu

1,1,1,3',3',3'-hexafluoro-propanol
920-66-1

1,1,1,3',3',3'-hexafluoro-propanol

C11H15F6NO3

C11H15F6NO3

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 4.5h;98%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H19N

C12H19N

C20H32N2O2

C20H32N2O2

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 8h;96%
N-Ac-Leu
1188-21-2

N-Ac-Leu

chloroacetonitrile
107-14-2

chloroacetonitrile

C10H16N2O3

C10H16N2O3

Conditions
ConditionsYield
With triethylamine In acetonitrile at 0 - 20℃; for 4.5h;96%
N-Ac-Leu
1188-21-2

N-Ac-Leu

(4R,5S)-1,5-Dimethyl-3-((2R,3S)-3-methyl-aziridine-2-carbonyl)-4-phenyl-imidazolidin-2-one
176791-95-0

(4R,5S)-1,5-Dimethyl-3-((2R,3S)-3-methyl-aziridine-2-carbonyl)-4-phenyl-imidazolidin-2-one

N-{(S)-1-[(2R,3S)-2-((4S,5R)-3,4-Dimethyl-2-oxo-5-phenyl-imidazolidine-1-carbonyl)-3-methyl-aziridine-1-carbonyl]-3-methyl-butyl}-acetamide
221374-48-7

N-{(S)-1-[(2R,3S)-2-((4S,5R)-3,4-Dimethyl-2-oxo-5-phenyl-imidazolidine-1-carbonyl)-3-methyl-aziridine-1-carbonyl]-3-methyl-butyl}-acetamide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane; acetonitrile for 12h; Ambient temperature;95%
N-Ac-Leu
1188-21-2

N-Ac-Leu

benzyl (R)-aziridine-2-carboxylate
86123-05-9

benzyl (R)-aziridine-2-carboxylate

benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate
260784-04-1

benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 6h; Acylation;95%
N-Ac-Leu
1188-21-2

N-Ac-Leu

(4R,5S,2'R)-1,5-dimethyl-3-[(2'-aziridinyl)carbonyl]-4-phenylimidazolidin-2-one
199122-48-0

(4R,5S,2'R)-1,5-dimethyl-3-[(2'-aziridinyl)carbonyl]-4-phenylimidazolidin-2-one

(4R,5S,2'R,2''S)-1,5-dimethyl-3-{[1'-(2''-acetamido-4''-methylpentanoyl)-2'-aziridinyl]carbonyl}-4-phenylimidazolidin-2-one
260783-98-0

(4R,5S,2'R,2''S)-1,5-dimethyl-3-{[1'-(2''-acetamido-4''-methylpentanoyl)-2'-aziridinyl]carbonyl}-4-phenylimidazolidin-2-one

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 6h; Acylation;95%
N-Ac-Leu
1188-21-2

N-Ac-Leu

2,2,2-trifluoroethyl trifluoromethanesulphonate
6226-25-1

2,2,2-trifluoroethyl trifluoromethanesulphonate

C10H16F3NO3

C10H16F3NO3

Conditions
ConditionsYield
Stage #1: N-Ac-Leu With caesium carbonate In acetonitrile at 20℃; for 0.333333h;
Stage #2: 2,2,2-trifluoroethyl trifluoromethanesulphonate In acetonitrile at 20℃; for 3h;
94%
formaldehyd
50-00-0

formaldehyd

N-Ac-Leu
1188-21-2

N-Ac-Leu

4-(S)-3-acetyl-4-isobutyl-5-oxazolidinone
125679-72-3

4-(S)-3-acetyl-4-isobutyl-5-oxazolidinone

Conditions
ConditionsYield
With K10 clay for 0.0333333h; Cyclization; microwave irradiation;93%
With diethyldichlorosilane Heating;60%
With toluene-4-sulfonic acid In benzene Heating;
With toluene-4-sulfonic acid In toluene
[(S)-1-((S)-1-{(S)-[(2R,3S)-2-((S)-1-Butylcarbamoyl-2-methyl-propylcarbamoyl)-tetrahydro-furan-3-yl]-hydroxy-methyl}-3-methyl-butylcarbamoyl)-3-methylsulfanyl-propyl]-carbamic acid tert-butyl ester
864366-92-7

[(S)-1-((S)-1-{(S)-[(2R,3S)-2-((S)-1-Butylcarbamoyl-2-methyl-propylcarbamoyl)-tetrahydro-furan-3-yl]-hydroxy-methyl}-3-methyl-butylcarbamoyl)-3-methylsulfanyl-propyl]-carbamic acid tert-butyl ester

N-Ac-Leu
1188-21-2

N-Ac-Leu

(2R,3S)-3-{(1S,2S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-4-methylsulfanyl-butyrylamino]-1-hydroxy-4-methyl-pentyl}-tetrahydro-furan-2-carboxylic acid ((S)-1-butylcarbamoyl-2-methyl-propyl)-amide

(2R,3S)-3-{(1S,2S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-4-methylsulfanyl-butyrylamino]-1-hydroxy-4-methyl-pentyl}-tetrahydro-furan-2-carboxylic acid ((S)-1-butylcarbamoyl-2-methyl-propyl)-amide

Conditions
ConditionsYield
With hydrogenchloride In various solvents at 0 - 5℃;92%
BOC-glycine
4530-20-5

BOC-glycine

N-Ac-Leu
1188-21-2

N-Ac-Leu

L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

N-(tert-butoxycarbonyl)-5-(N,O-dimethyl-hydroxamide)-glutamine

N-(tert-butoxycarbonyl)-5-(N,O-dimethyl-hydroxamide)-glutamine

Ph3P=CH-COOEt

Ph3P=CH-COOEt

(Z)-(S)-6-((S)-2-Acetylamino-4-methyl-pentanoylamino)-6-{(S)-1-[(S)-1-(carboxymethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-hex-2-enoic acid ethyl ester

(Z)-(S)-6-((S)-2-Acetylamino-4-methyl-pentanoylamino)-6-{(S)-1-[(S)-1-(carboxymethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-hex-2-enoic acid ethyl ester

Conditions
ConditionsYield
Solid phase reaction;90%
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
253168-94-4

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

N-Ac-Leu
1188-21-2

N-Ac-Leu

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
608141-43-1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

Conditions
ConditionsYield
In methanol at 20℃; for 8h; Reflux; Resolution of racemate;90%
Stage #1: 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine; N-Ac-Leu In methanol for 1h; Reflux;
Stage #2: In methanol at 20℃; for 4h; Reflux;
90%
In methanol at 20℃; for 4h; Reflux;90%
N-Ac-Leu
1188-21-2

N-Ac-Leu

diethyltin(IV) oxide
3682-12-0

diethyltin(IV) oxide

(C8H14NO3Sn(C2H5)2)2O

(C8H14NO3Sn(C2H5)2)2O

Conditions
ConditionsYield
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.;90%
N-Ac-Leu
1188-21-2

N-Ac-Leu

dimethyltin oxide
2273-45-2

dimethyltin oxide

(C8H14NO3Sn(CH3)2)2O

(C8H14NO3Sn(CH3)2)2O

Conditions
ConditionsYield
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.;90%
N-Ac-Leu
1188-21-2

N-Ac-Leu

methyl iodide
74-88-4

methyl iodide

N-acetyl-L-leucine methyl ester
1492-11-1

N-acetyl-L-leucine methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide89%
Stage #1: N-Ac-Leu With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 24h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 25℃; for 24h;
N-Ac-Leu
1188-21-2

N-Ac-Leu

N-methylglycine methyl ester hydrochloride
13515-93-0

N-methylglycine methyl ester hydrochloride

N-acetyl-L-leucyl-N-methylglycine methyl ester

N-acetyl-L-leucyl-N-methylglycine methyl ester

Conditions
ConditionsYield
Stage #1: N-Ac-Leu With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h;
Stage #2: N-methylglycine methyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;
89%
methanol
67-56-1

methanol

N-Ac-Leu
1188-21-2

N-Ac-Leu

N-acetyl-L-leucine methyl ester
1492-11-1

N-acetyl-L-leucine methyl ester

Conditions
ConditionsYield
With thionyl chloride at 0℃; for 4h;88%
N-Ac-Leu
1188-21-2

N-Ac-Leu

di(n-butyl)tin oxide
818-08-6

di(n-butyl)tin oxide

(C8H14NO3Sn(C4H9)2)2O

(C8H14NO3Sn(C4H9)2)2O

Conditions
ConditionsYield
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.;87%
N-Ac-Leu
1188-21-2

N-Ac-Leu

(S)-(9H-fluoren-9-yl)methyl (4,5-diamino-5-oxopentyl)carbamate

(S)-(9H-fluoren-9-yl)methyl (4,5-diamino-5-oxopentyl)carbamate

(9H-fluoren-9-yl)methyl ((S)-4-((S)-2-acetamido-4-methylpentanamido)-5-amino-5-oxopentyl)carbamate

(9H-fluoren-9-yl)methyl ((S)-4-((S)-2-acetamido-4-methylpentanamido)-5-amino-5-oxopentyl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In acetonitrile at 20℃; for 2h; Inert atmosphere;87%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H14(2)H3NO4S

C12H14(2)H3NO4S

C12H15(2)H4NO4S*C8H15NO3

C12H15(2)H4NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H14(2)H3NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 20 - 55℃;
86%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C15H17Cl2NO3

C15H17Cl2NO3

((S)-2-acetamido-4-methylpentanoyloxy)methyl (S)-1-(2-chlorophenyl)-2-oxocyclohexyl(methyl)carbamate

((S)-2-acetamido-4-methylpentanoyloxy)methyl (S)-1-(2-chlorophenyl)-2-oxocyclohexyl(methyl)carbamate

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In acetone at 70℃; for 1h;86%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-Ac-Leu
1188-21-2

N-Ac-Leu

N-acetyl-L-leucine N-hydroxysuccinimide ester
39740-61-9

N-acetyl-L-leucine N-hydroxysuccinimide ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃;85%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H14(2)H3NO4S

C12H14(2)H3NO4S

C12H13(2)H6NO4S*C8H15NO3

C12H13(2)H6NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H14(2)H3NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In methanol; 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 20 - 55℃;
85%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H10(2)H7NO4S

C12H10(2)H7NO4S

C12H11(2)H8NO4S*C8H15NO3

C12H11(2)H8NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H10(2)H7NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 20 - 55℃; for 1h;
85%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H5(2)H12NO4S

C12H5(2)H12NO4S

C12H5(2)H14NO4S*C8H15NO3

C12H5(2)H14NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H5(2)H12NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 55℃; for 1h;
85%
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