Product Name

  • Name

    N-Acetyl-L-leucine

  • EINECS 214-706-3
  • CAS No. 1188-21-2
  • Article Data45
  • CAS DataBase
  • Density 1.069 g/cm3
  • Solubility 0.81 g/100 mL (20 °C) in water
  • Melting Point 187-190 °C(lit.)
  • Formula C8H15NO3
  • Boiling Point 369.7 °C at 760mmHg
  • Molecular Weight 173.212
  • Flash Point 177.4 °C
  • Transport Information
  • Appearance white crystalline powder
  • Safety 24/25-36-26
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 1188-21-2 (N-Acetyl-L-leucine)
  • Hazard Symbols IrritantXi
  • Synonyms Leucine,N-acetyl-, L- (8CI);(S)-2-Acetamido-4-methylpentanoic acid;Acetyl-L-leucine;Acetylleucine;N-Acetyl-L-(-)-leucine;
  • PSA 66.40000
  • LogP 1.01270

Synthetic route

(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid
64896-30-6

(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With hydrogen; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; triethylamine; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane In tetrahydrofuran at 20℃; under 750.075 Torr; for 24h;100%
With hydrogen; Rh(I)-(S)-chairphos In tetrahydrofuran Product distribution; Ambient temperature; other catalyst; other solvents; influence on products' optical yields;
With hydrogen; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine); [rhodium(I)(norborna-2,5-diene)2]SbF6 In dichloromethane at 20℃; under 1292.87 Torr; for 24h;
With chiral (1,1'-ferrocenediyl)bis(phospholo[3,4-d][1,3]dioxole); hydrogen; bis(1,5-cyclooctadiene)rhodium(I) hexafluorophosphate In tetrahydrofuran at 20℃; under 775.743 Torr; for 1h;
L-leucine
61-90-5

L-leucine

acetic anhydride
108-24-7

acetic anhydride

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
In water for 0.0666667h; Irradiation;98%
With sodium hydrogencarbonate In water at 0 - 20℃; for 5h;89%
With triethylamine In water at 20℃;35%
methyl N-acetyl-leucinate
57289-25-5

methyl N-acetyl-leucinate

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

methyl (R)-2-(N-acetylamino)-4-methylpentanoate
35799-87-2

methyl (R)-2-(N-acetylamino)-4-methylpentanoate

Conditions
ConditionsYield
With sodium hydroxide; phosphate buffer; pronase EC 3.4.24.4 In tetrahydrofuran Ambient temperature;A 79%
B 91%
L-Norvaline
6600-40-4

L-Norvaline

acetic anhydride
108-24-7

acetic anhydride

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
at 0 - 20℃;89%
(S)-benzyl 2-acetamido-4-methylpentanoate
244250-56-4

(S)-benzyl 2-acetamido-4-methylpentanoate

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h;81%
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h;81%
Ketene
463-51-4

Ketene

L-leucine
61-90-5

L-leucine

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With sodium hydroxide
N-acetylleucine
99-15-0

N-acetylleucine

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With (-)-α-fenchylamine
methyl N-acetyl-leucinate
57289-25-5

methyl N-acetyl-leucinate

N-Ac-Leu
1188-21-2

N-Ac-Leu

methyl N-acetyl-leucinate
57289-25-5

methyl N-acetyl-leucinate

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
for 118h; carbonate hydrolyase EC 4.2.2.1 (bovine carbonic anhydrase, BCA), pH 7.5; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
ethyl N-acetyl-leucinate
4071-36-7

ethyl N-acetyl-leucinate

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-O-ethyl-D-leucine
75552-78-2

N-acetyl-O-ethyl-D-leucine

Conditions
ConditionsYield
In ethanol; water at 35℃; for 48h; Yield given;
2-acetylamino-4-methyl-pent-2-enoic acid
915008-30-9

2-acetylamino-4-methyl-pent-2-enoic acid

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With hydrogen; <(2R,3R)-2,3-Bis(diphenylphosphino)butan>(ϖ-norbornadien)rhodium(I)-perchlorate In tetrahydrofuran under 3000.2 Torr; for 8h; Yield given;
2-acetylamino-4-methyl-pent-2-enoic acid
915008-30-9

2-acetylamino-4-methyl-pent-2-enoic acid

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With hydrogen; ClO4; (2R,3S)-1,2-bis(diphenylphosphino)-3-tBoc-aminobutane In ethanol for 22h; Ambient temperature; Yield given;
With ; hydrogen In ethanol at 20℃; under 760 Torr; Title compound not separated from byproducts;
(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid
64896-30-6

(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With <(1R;2R-MAC-PONP)Rh(COD)>(+)BF4(-); hydrogen In methanol at 30℃; under 750.06 Torr; Title compound not separated from byproducts;
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; triethylamine; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane In tetrahydrofuran under 760 Torr; for 24h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With hydrogen; triethylamine; ClO4; (2S,4S)-MOD-BPPM In ethanol at 50℃; under 15200 Torr; for 20h; Title compound not separated from byproducts;
(1'S,3S)-8-acetoxy-3-<1'-(acetylamino)-3'-methylbutyl>-3,4-dihydro-1-oxo-1H-2-benzopyran
85785-66-6

(1'S,3S)-8-acetoxy-3-<1'-(acetylamino)-3'-methylbutyl>-3,4-dihydro-1-oxo-1H-2-benzopyran

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With potassium permanganate; magnesium sulfate In water for 1.5h; Heating;
L-leucine
61-90-5

L-leucine

4-nitrophenol acetate
830-03-5

4-nitrophenol acetate

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
β‐cyclodextrin In water; dimethyl sulfoxide at 25℃; Rate constant; Mechanism; various conditions;
N-acetyl-DL-isoleucine butyl ester
2256-97-5

N-acetyl-DL-isoleucine butyl ester

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With rice bran lipase; sodium chloride at 30℃; pH=7.5; Title compound not separated from byproducts;
acetamide
60-35-5

acetamide

carbon monoxide
201230-82-2

carbon monoxide

isovaleraldehyde
590-86-3

isovaleraldehyde

A

N-Ac-Leu
1188-21-2

N-Ac-Leu

B

N-acetyl-D-leucine
19764-30-8

N-acetyl-D-leucine

Conditions
ConditionsYield
With sulfuric acid; lithium bromide; bis(triphenylphosphine)palladium dibromide In various solvent(s) at 120℃; under 45003.6 Torr; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
Ketene
463-51-4

Ketene

L-leucine
61-90-5

L-leucine

alkali

alkali

N-Ac-Leu
1188-21-2

N-Ac-Leu

DL-leucine methyl ester
18869-43-7

DL-leucine methyl ester

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaOCH3 / Brenner esterification
2: pyridine
3: H2O; ethanol / 48 h / 35 °C
View Scheme
DL-leucine ethyl ester
2899-43-6

DL-leucine ethyl ester

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: H2O; ethanol / 48 h / 35 °C
View Scheme
(3S)-3-<(1'S)-1'-amino-3'-methylbutyl>-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one
57765-73-8

(3S)-3-<(1'S)-1'-amino-3'-methylbutyl>-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / pyridine / 2 h / 50 °C
2: KMnO4, MgSO4 / H2O / 1.5 h / Heating
View Scheme
C8H13NO3
74839-85-3

C8H13NO3

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With {Rh[ZhangPhos](nbd)}BF4; hydrogen In methanol at 20℃; under 1034.32 Torr; for 12h; optical yield given as %ee; enantioselective reaction;
L-leucine
61-90-5

L-leucine

acetyl chloride
75-36-5

acetyl chloride

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
With potassium carbonate In 1,4-dioxane; water
L-leucine benzyl ester p-toluenesulfonate
1738-77-8

L-leucine benzyl ester p-toluenesulfonate

N-Ac-Leu
1188-21-2

N-Ac-Leu

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 50 °C
View Scheme
(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
608141-42-0

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

N-Ac-Leu
1188-21-2

N-Ac-Leu

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
608141-43-1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

Conditions
ConditionsYield
In methanol for 1h; Reflux;98.3%
In methanol at 65 - 70℃;
In methanol for 1h; Reflux;1670 g
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
253168-94-4

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

N-Ac-Leu
1188-21-2

N-Ac-Leu

1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-ethylamine N-acetyl-L-leucine salt

1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-ethylamine N-acetyl-L-leucine salt

Conditions
ConditionsYield
In methanol at 20℃; for 4h; Reflux;98%
N-Ac-Leu
1188-21-2

N-Ac-Leu

1,1,1,3',3',3'-hexafluoro-propanol
920-66-1

1,1,1,3',3',3'-hexafluoro-propanol

C11H15F6NO3

C11H15F6NO3

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 4.5h;98%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H19N

C12H19N

C20H32N2O2

C20H32N2O2

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 8h;96%
N-Ac-Leu
1188-21-2

N-Ac-Leu

chloroacetonitrile
107-14-2

chloroacetonitrile

C10H16N2O3

C10H16N2O3

Conditions
ConditionsYield
With triethylamine In acetonitrile at 0 - 20℃; for 4.5h;96%
N-Ac-Leu
1188-21-2

N-Ac-Leu

(4R,5S)-1,5-Dimethyl-3-((2R,3S)-3-methyl-aziridine-2-carbonyl)-4-phenyl-imidazolidin-2-one
176791-95-0

(4R,5S)-1,5-Dimethyl-3-((2R,3S)-3-methyl-aziridine-2-carbonyl)-4-phenyl-imidazolidin-2-one

N-{(S)-1-[(2R,3S)-2-((4S,5R)-3,4-Dimethyl-2-oxo-5-phenyl-imidazolidine-1-carbonyl)-3-methyl-aziridine-1-carbonyl]-3-methyl-butyl}-acetamide
221374-48-7

N-{(S)-1-[(2R,3S)-2-((4S,5R)-3,4-Dimethyl-2-oxo-5-phenyl-imidazolidine-1-carbonyl)-3-methyl-aziridine-1-carbonyl]-3-methyl-butyl}-acetamide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane; acetonitrile for 12h; Ambient temperature;95%
N-Ac-Leu
1188-21-2

N-Ac-Leu

benzyl (R)-aziridine-2-carboxylate
86123-05-9

benzyl (R)-aziridine-2-carboxylate

benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate
260784-04-1

benzyl (2R,2'S)-1-(2'-acetamido-4'-methylpentanoyl)aziridine-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 6h; Acylation;95%
N-Ac-Leu
1188-21-2

N-Ac-Leu

(4R,5S,2'R)-1,5-dimethyl-3-[(2'-aziridinyl)carbonyl]-4-phenylimidazolidin-2-one
199122-48-0

(4R,5S,2'R)-1,5-dimethyl-3-[(2'-aziridinyl)carbonyl]-4-phenylimidazolidin-2-one

(4R,5S,2'R,2''S)-1,5-dimethyl-3-{[1'-(2''-acetamido-4''-methylpentanoyl)-2'-aziridinyl]carbonyl}-4-phenylimidazolidin-2-one
260783-98-0

(4R,5S,2'R,2''S)-1,5-dimethyl-3-{[1'-(2''-acetamido-4''-methylpentanoyl)-2'-aziridinyl]carbonyl}-4-phenylimidazolidin-2-one

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 6h; Acylation;95%
N-Ac-Leu
1188-21-2

N-Ac-Leu

2,2,2-trifluoroethyl trifluoromethanesulphonate
6226-25-1

2,2,2-trifluoroethyl trifluoromethanesulphonate

C10H16F3NO3

C10H16F3NO3

Conditions
ConditionsYield
Stage #1: N-Ac-Leu With caesium carbonate In acetonitrile at 20℃; for 0.333333h;
Stage #2: 2,2,2-trifluoroethyl trifluoromethanesulphonate In acetonitrile at 20℃; for 3h;
94%
formaldehyd
50-00-0

formaldehyd

N-Ac-Leu
1188-21-2

N-Ac-Leu

4-(S)-3-acetyl-4-isobutyl-5-oxazolidinone
125679-72-3

4-(S)-3-acetyl-4-isobutyl-5-oxazolidinone

Conditions
ConditionsYield
With K10 clay for 0.0333333h; Cyclization; microwave irradiation;93%
With diethyldichlorosilane Heating;60%
With toluene-4-sulfonic acid In benzene Heating;
With toluene-4-sulfonic acid In toluene
[(S)-1-((S)-1-{(S)-[(2R,3S)-2-((S)-1-Butylcarbamoyl-2-methyl-propylcarbamoyl)-tetrahydro-furan-3-yl]-hydroxy-methyl}-3-methyl-butylcarbamoyl)-3-methylsulfanyl-propyl]-carbamic acid tert-butyl ester
864366-92-7

[(S)-1-((S)-1-{(S)-[(2R,3S)-2-((S)-1-Butylcarbamoyl-2-methyl-propylcarbamoyl)-tetrahydro-furan-3-yl]-hydroxy-methyl}-3-methyl-butylcarbamoyl)-3-methylsulfanyl-propyl]-carbamic acid tert-butyl ester

N-Ac-Leu
1188-21-2

N-Ac-Leu

(2R,3S)-3-{(1S,2S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-4-methylsulfanyl-butyrylamino]-1-hydroxy-4-methyl-pentyl}-tetrahydro-furan-2-carboxylic acid ((S)-1-butylcarbamoyl-2-methyl-propyl)-amide

(2R,3S)-3-{(1S,2S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-4-methylsulfanyl-butyrylamino]-1-hydroxy-4-methyl-pentyl}-tetrahydro-furan-2-carboxylic acid ((S)-1-butylcarbamoyl-2-methyl-propyl)-amide

Conditions
ConditionsYield
With hydrogenchloride In various solvents at 0 - 5℃;92%
BOC-glycine
4530-20-5

BOC-glycine

N-Ac-Leu
1188-21-2

N-Ac-Leu

L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

N-(tert-butoxycarbonyl)-5-(N,O-dimethyl-hydroxamide)-glutamine

N-(tert-butoxycarbonyl)-5-(N,O-dimethyl-hydroxamide)-glutamine

Ph3P=CH-COOEt

Ph3P=CH-COOEt

(Z)-(S)-6-((S)-2-Acetylamino-4-methyl-pentanoylamino)-6-{(S)-1-[(S)-1-(carboxymethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-hex-2-enoic acid ethyl ester

(Z)-(S)-6-((S)-2-Acetylamino-4-methyl-pentanoylamino)-6-{(S)-1-[(S)-1-(carboxymethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-hex-2-enoic acid ethyl ester

Conditions
ConditionsYield
Solid phase reaction;90%
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
253168-94-4

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

N-Ac-Leu
1188-21-2

N-Ac-Leu

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
608141-43-1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

Conditions
ConditionsYield
In methanol at 20℃; for 8h; Reflux; Resolution of racemate;90%
Stage #1: 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine; N-Ac-Leu In methanol for 1h; Reflux;
Stage #2: In methanol at 20℃; for 4h; Reflux;
90%
In methanol at 20℃; for 4h; Reflux;90%
N-Ac-Leu
1188-21-2

N-Ac-Leu

diethyltin(IV) oxide
3682-12-0

diethyltin(IV) oxide

(C8H14NO3Sn(C2H5)2)2O

(C8H14NO3Sn(C2H5)2)2O

Conditions
ConditionsYield
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.;90%
N-Ac-Leu
1188-21-2

N-Ac-Leu

dimethyltin oxide
2273-45-2

dimethyltin oxide

(C8H14NO3Sn(CH3)2)2O

(C8H14NO3Sn(CH3)2)2O

Conditions
ConditionsYield
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.;90%
N-Ac-Leu
1188-21-2

N-Ac-Leu

methyl iodide
74-88-4

methyl iodide

N-acetyl-L-leucine methyl ester
1492-11-1

N-acetyl-L-leucine methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide89%
Stage #1: N-Ac-Leu With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 24h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 25℃; for 24h;
N-Ac-Leu
1188-21-2

N-Ac-Leu

N-methylglycine methyl ester hydrochloride
13515-93-0

N-methylglycine methyl ester hydrochloride

N-acetyl-L-leucyl-N-methylglycine methyl ester

N-acetyl-L-leucyl-N-methylglycine methyl ester

Conditions
ConditionsYield
Stage #1: N-Ac-Leu With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h;
Stage #2: N-methylglycine methyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;
89%
methanol
67-56-1

methanol

N-Ac-Leu
1188-21-2

N-Ac-Leu

N-acetyl-L-leucine methyl ester
1492-11-1

N-acetyl-L-leucine methyl ester

Conditions
ConditionsYield
With thionyl chloride at 0℃; for 4h;88%
N-Ac-Leu
1188-21-2

N-Ac-Leu

di(n-butyl)tin oxide
818-08-6

di(n-butyl)tin oxide

(C8H14NO3Sn(C4H9)2)2O

(C8H14NO3Sn(C4H9)2)2O

Conditions
ConditionsYield
In ethanol; benzene byproducts: H2O; acid:R2SnO molar ratio 1:1, benzene-ethanol; azeotropic removal of water, filtered, solvent was removed; solidified on trituration with petroleum ether; elem. anal.;87%
N-Ac-Leu
1188-21-2

N-Ac-Leu

(S)-(9H-fluoren-9-yl)methyl (4,5-diamino-5-oxopentyl)carbamate

(S)-(9H-fluoren-9-yl)methyl (4,5-diamino-5-oxopentyl)carbamate

(9H-fluoren-9-yl)methyl ((S)-4-((S)-2-acetamido-4-methylpentanamido)-5-amino-5-oxopentyl)carbamate

(9H-fluoren-9-yl)methyl ((S)-4-((S)-2-acetamido-4-methylpentanamido)-5-amino-5-oxopentyl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In acetonitrile at 20℃; for 2h; Inert atmosphere;87%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H14(2)H3NO4S

C12H14(2)H3NO4S

C12H15(2)H4NO4S*C8H15NO3

C12H15(2)H4NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H14(2)H3NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 20 - 55℃;
86%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C15H17Cl2NO3

C15H17Cl2NO3

((S)-2-acetamido-4-methylpentanoyloxy)methyl (S)-1-(2-chlorophenyl)-2-oxocyclohexyl(methyl)carbamate

((S)-2-acetamido-4-methylpentanoyloxy)methyl (S)-1-(2-chlorophenyl)-2-oxocyclohexyl(methyl)carbamate

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In acetone at 70℃; for 1h;86%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-Ac-Leu
1188-21-2

N-Ac-Leu

N-acetyl-L-leucine N-hydroxysuccinimide ester
39740-61-9

N-acetyl-L-leucine N-hydroxysuccinimide ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃;85%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H14(2)H3NO4S

C12H14(2)H3NO4S

C12H13(2)H6NO4S*C8H15NO3

C12H13(2)H6NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H14(2)H3NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In methanol; 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 20 - 55℃;
85%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H10(2)H7NO4S

C12H10(2)H7NO4S

C12H11(2)H8NO4S*C8H15NO3

C12H11(2)H8NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H10(2)H7NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 20 - 55℃; for 1h;
85%
N-Ac-Leu
1188-21-2

N-Ac-Leu

C12H5(2)H12NO4S

C12H5(2)H12NO4S

C12H5(2)H14NO4S*C8H15NO3

C12H5(2)H14NO4S*C8H15NO3

Conditions
ConditionsYield
Stage #1: C12H5(2)H12NO4S With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; deuterium In 2,2,2-trifluoroethanol at 50℃; under 2585.81 Torr; for 16h;
Stage #2: N-Ac-Leu In methanol at 55℃; for 1h;
85%

N-Acetyl-L-leucine Specification

1. Introduction of N-Acetyl-L-leucine

N-Acetyl-L-leucine, with the IUPAC Name: (2S)-2-acetamido-4-methylpentanoic acid, is one kind of powder.
And it belongs to the Product Categories which include Amino Acids Derivatives; Amino Acid Derivatives; Amino Acids; Leucine [Leu, L]; Amino Acids and Derivatives; Ac-Amino Acids; Amino Acids (N-Protected); Biochemistry; N-Acetyl-Amino acid series; Amino Acid Derivatives; Leucine; Peptide Synthesis. When comes to the application, it is one type of biochemical reagent.

2. Properties of N-Acetyl-L-leucine

N-Acetyl-L-leucine has the following property datas: (1)XLogP3: 0.5; (2)H-Bond Donor: 2; (3)H-Bond Acceptor: 3; (4)EINECS: 214-706-3; (5)Melting Point: 187-190 °C(lit.); (6)Surface Tension: 37.2 dyne/cm; (7)Water Solubility: 0.81 g/100 mL (20 °C); (8)Density: 1.069 g/cm3; (9)Flash Point: 177.4 °C; (10)Enthalpy of Vaporization: 67.7 kJ/mol; (11)Boiling Point: 369.7 °C at 760 mmHg; (12)Vapour Pressure: 1.77E-06 mmHg at 25°C. When comes to the usage, it could be used for treating vestibular-related imbalance and vertigo.

3. Safty information about N-Acetyl-L-leucine
Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26 
S24/25:Avoid contact with skin and eyes. 
S36:Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
HazardClass: IRRITANT

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