181289-15-6

Basic information

• Product Name: 3-Carbamoymethyl-5-methylhexanoic acid
• Synonyms: 3-Carbamoymethyl-5-methylhexanoic acid;3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid;3-Carbamoymethyl-5-methylhexanoic acid (Pregabalin);()-3-(AMIOMETHYL)-5-METHYLHEXANOIC ACID;Pregabalin intermediate;3-Carbamoymethyl-5-m;3-(Carbamoylmethyi-5-methyl hexanoic acid;(2-aMino-2-oxoethyl)-5-Methylhexanoic acid
• CAS NO: 181289-15-6
• Molecular Formula: C₉H₁₇NO₃
• Molecular Weight: 187.24
• EINECS: 1806241-263-5
• Product Categories: intermidiate of Pregablin;Pharmaceutical material and intermeidates;APIs Intermediate
• Mol File: 181289-15-6.mol
• Article Data: 16

Chemical Properties

• Melting Point: 106-108°C
• Boiling Point: 401.9 °C at 760 mmHg
• Flash Point: 196.9 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 1.39E-07mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• PKA: 4.68±0.10(Predicted)
• CAS DataBase Reference: 3-Carbamoymethyl-5-methylhexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Carbamoymethyl-5-methylhexanoic acid(181289-15-6)
• EPA Substance Registry System: 3-Carbamoymethyl-5-methylhexanoic acid(181289-15-6)

Safety Data

• Hazardous Substances Data: 181289-15-6(Hazardous Substances Data)

Usage

Description

3-Carbamoymethyl-5-methylhexanoic acid, also known as Pregabalin, is a GABA analogue derived from amino acids. It possesses unique chemical properties that allow it to interact with the central nervous system, making it a promising pharmaceutical candidate for various applications.

Uses

Used in Pharmaceutical Industry:
3-Carbamoymethyl-5-methylhexanoic acid is used as an anticonvulsant intermediate for the synthesis of Pregabalin (P704800). 3-Carbamoymethyl-5-methylhexanoic acid acts on the central nervous system to reduce the frequency and severity of seizures, providing relief to patients suffering from epilepsy and other seizure disorders.
Additionally, Pregabalin has been found to be effective in managing neuropathic pain, which is pain caused by nerve damage. It is also used to treat generalized anxiety disorder and fibromyalgia, further showcasing its versatility in the pharmaceutical industry.

Physical Form

Powder

InChI:InChI=1/C9H17NO3/c1-6(2)3-7(4-8(10)11)5-9(12)13/h6-7H,3-5H2,1-2H3,(H2,10,11)(H,12,13)

Synthetic route

3-isobutylglutaric anhydride (185815-59-2) → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
With ammonia In water at -10 - 40℃; for 1.5h;	100%
With ammonium hydroxide at 10℃; for 2h; Temperature;	95%
Stage #1: 3-isobutylglutaric anhydride With ammonia In tert-butyl methyl ether; water at 0 - 20℃; Stage #2: With hydrogenchloride In tert-butyl methyl ether; water pH=2;	80.4%

5-methyl-3-carboxymethylhexanoic acid (75143-89-4) → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
With urea In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; for 3h; Temperature; Solvent;	93.5%
With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate In acetonitrile at 5 - 20℃; for 0.5h; Solvent;	72.4%
With hydrogenchloride; ammonium hydroxide; acetic anhydride In tert-butyl methyl ether; water; ethyl acetate

3-isobutylglutarimide → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
With potassium carbonate In 5,5-dimethyl-1,3-cyclohexadiene; water at 30℃; for 1h; Reagent/catalyst; Temperature;	86.6%
Stage #1: 3-isobutylglutarimide With water; sodium hydroxide at 60℃; for 1h; Stage #2: With hydrogenchloride; water	31 g
With sodium hydroxide at 50 - 90℃;

C10H15NO4 → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
With water; sodium hydroxide at 65℃; for 0.583333h; Temperature;	79%

methyl 3-(2-amino-2-oxoethyl)-5-methylhexanoate → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
With water; lithium hydroxide In tetrahydrofuran; methanol at 20℃; for 3h;	76%

(1'SR,3 SR)-1-(1'-napthyl)ethyl-3-(carboxylomethyl)-5-methylhexanoate (1385049-46-6) → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
Stage #1: (1'SR,3 SR)-1-(1'-napthyl)ethyl-3-(carboxylomethyl)-5-methylhexanoate With chloroformic acid ethyl ester; triethylamine In acetone at -20℃; Inert atmosphere; Stage #2: With ammonia In water; acetone at -20℃; for 2h; Stage #3: With sodium hydroxide In water at 0℃;	58%

tert-butyl methyl ether (1634-04-4) → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
With ammonium hydroxide In water

(S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid (181289-34-9) → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
Stage #1: (S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid With toluene-4-sulfonic acid In toluene Reflux; Stage #2: With sodium hydroxide In water; toluene at 25 - 65℃; Stage #3: With hydrogenchloride In water at 10 - 15℃; for 1.5h; Product distribution / selectivity;

isovaleraldehyde (590-86-3) → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: di-n-propylamine; ethyl 2-cyanoacetate / cyclohexane / 2 h / 25 - 30 °C / Reflux 1.2: 5.17 h / 25 - 50 °C 1.3: 48 h / Reflux 2.1: urea / 12 h / 130 - 135 °C 2.2: 60 - 90 °C View Scheme
Multi-step reaction with 5 steps 1.1: piperidine; pyridine; acetic acid / hexane / 48 h / Reflux; Inert atmosphere 2.1: di-n-propylamine / 16 h / 15 - 55 °C 3.1: hydrogen bromide / water / 72 h / 100 °C 4.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 5.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 5.2: pH 2 View Scheme
Multi-step reaction with 6 steps 1.1: piperidine; pyridine; acetic acid / hexane / 48 h / Reflux; Inert atmosphere 2.1: di-n-propylamine / 16 h / 15 - 55 °C 3.1: hydrogen bromide / water / 72 h / 100 °C 4.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 5.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere 6.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere 6.2: 2 h / -20 °C 6.3: 0 °C View Scheme
Multi-step reaction with 4 steps 1: tetramethyl ammoniumhydroxide; trimethyldodecylammonium chloride / ethanol / 6 h / 25 °C 2: water; hydrogenchloride / 30 h / 140 °C / pH 1 - 2 3: acetic anhydride / 2 h / 120 °C 4: ammonium hydroxide / 2 h / 10 °C View Scheme
Multi-step reaction with 4 steps 1.1: piperidine / hexane / 100 °C / Dean-Stark 2.1: piperidine / 2 h / 55 °C 2.2: 72 h / 100 - 120 °C 3.1: 5 h / 160 °C 4.1: sodium hydroxide; water / 0.58 h / 65 °C View Scheme

diethyl 2-(3-methylbutylidene)malonate (51615-30-6) → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: di-n-propylamine / 16 h / 15 - 55 °C 2.1: hydrogen bromide / water / 72 h / 100 °C 3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 4.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 4.2: pH 2 View Scheme
Multi-step reaction with 5 steps 1.1: di-n-propylamine / 16 h / 15 - 55 °C 2.1: hydrogen bromide / water / 72 h / 100 °C 3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 4.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere 5.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere 5.2: 2 h / -20 °C 5.3: 0 °C View Scheme

2-isobutyl-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester (102710-09-8) → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: hydrogen bromide / water / 72 h / 100 °C 2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 3.2: pH 2 View Scheme
Multi-step reaction with 4 steps 1.1: hydrogen bromide / water / 72 h / 100 °C 2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 3.1: 1,4-diaza-bicyclo[2.2.2]octane / tert-butyl methyl ether / 2 h / -78 °C / Inert atmosphere 4.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere 4.2: 2 h / -20 °C 4.3: 0 °C View Scheme

2,4-dicyano-3-isobutylglutaramide → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: water; hydrogenchloride / 30 h / 140 °C / pH 1 - 2 2: acetic anhydride / 2 h / 120 °C 3: ammonium hydroxide / 2 h / 10 °C View Scheme

2‑cyano‑5‑methylhex‑2‑enoic acid methyl ester (868-52-0) → (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: piperidine / 2 h / 55 °C 1.2: 72 h / 100 - 120 °C 2.1: 5 h / 160 °C 3.1: sodium hydroxide; water / 0.58 h / 65 °C View Scheme

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) → (3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid (181289-33-8)

Conditions	Yield
With D-phenylglycine butyl ester In isopropyl alcohol Heating;	90.39%
With (R)-1-phenyl-ethyl-amine In methanol; chloroform at 25 - 40℃; for 3.16h; Solvent; Temperature;	41%
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With (R)-1-phenyl-ethyl-amine In ethanol; chloroform for 0.75h; Reflux; Stage #2: With hydrogenchloride In ethanol; chloroform; water for 0.75h; Cooling;	40%

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) → (R,S)-3-iso-butyl-4-aminobutyric acid (128013-69-4, 130912-52-6, 148553-50-8, 148553-51-9)

Conditions	Yield
With bromine; sodium hydroxide In water at 0 - 85℃; for 3h; Temperature; Large scale;	89%
With bromine; sodium hydroxide In water at 5 - 60℃; for 2h;	81%
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With sodium hydroxide; water; bromine at 5 - 60℃; for 0.5h; Hofmann Rearrangement; Stage #2: With sulfuric acid In 2-methyl-propan-1-ol; water Stage #3: With tributyl-amine In 2-methyl-propan-1-ol at 2 - 10℃; for 1.5 - 2h; Product distribution / selectivity;	80.4%

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + (R)-1-phenyl-ethyl-amine (3886-69-9) → (R)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine (185815-61-6) + (S)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine

Conditions	Yield
In chloroform at 55℃; for 1.5h;	A 79.2% B n/a

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + Quinine (130-95-0) → R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid quinine salt

Conditions	Yield
With acetone In water at 80℃;	67.9%

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + (R)-1-(1-Naphthyl)ethylamine (3886-70-2) → (R)-(+)-1-(1-naphthyl)ethylamine salt of (S)-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid (1001296-58-7)

Conditions	Yield
In methanol; ethyl acetate at 25 - 68℃; Heating / reflux;

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + (2S)-2-phenylglycinol (20989-17-7) → (S)-(+)-phenylglycinol salt of (S)-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid (1001296-60-1)

Conditions	Yield
In methanol; ethyl acetate at 25 - 68℃; Heating / reflux;

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + (R)-Phenylglycinol (56613-80-0) → (R)-(-)-phenylglycinol salt of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid (1001296-65-6)

Conditions	Yield
In 1,4-dioxane at 25 - 90℃;

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) → pregabilin (148553-50-8)

Conditions	Yield
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With sodium hydroxide; water; bromine at 10 - 60℃; for 0.5 - 5.75h; Hofmann Rearrangement; Stage #2: With sulfuric acid In 2-methyl-propan-1-ol; water at 20℃; for 0.5 - 24h; Stage #3: With tributyl-amine In 2-methyl-propan-1-ol at 2℃; for 1.5 - 2h; Product distribution / selectivity;
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With sodium hydroxide; water; bromine at 15 - 60℃; for 0.5h; Hofmann Rearrangement; Stage #2: With sulfuric acid In 2-methyl-propan-1-ol; water Stage #3: With tributyl-amine In 2-methyl-propan-1-ol; water at 2℃; for 2h; Product distribution / selectivity;
Multi-step reaction with 2 steps 1.1: chloroform / 0.5 h / 50 - 55 °C 2.1: sodium hydroxide; bromine / water / 1.25 h / -5 - 55 °C 2.2: 0 - 5 °C / pH 6.7 View Scheme
Multi-step reaction with 3 steps 1.1: chloroform / 0.92 h / 52.5 °C 2.1: hydrogenchloride / water / 22.5 - 42.5 °C 3.1: sodium hydroxide; sodium hypochlorite / water / 3.04 h / 7.5 - 42.5 °C 3.2: 0.29 h / 27.5 °C View Scheme

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + chloroformic acid ethyl ester (541-41-3) → C12H22N2O4

Conditions	Yield
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid; chloroformic acid ethyl ester With triethylamine In tetrahydrofuran at -10℃; for 0.5h; Stage #2: With sodium azide In tetrahydrofuran; water at -10℃; for 2h;

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + (R)-1-phenyl-ethyl-amine (3886-69-9) → (R)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine (185815-61-6)

Conditions	Yield
In ethanol; chloroform at 30 - 55℃; for 1h; Product distribution / selectivity;
In chloroform; isopropyl alcohol at 30 - 60℃; for 3.75h; Product distribution / selectivity;
In acetone at 30 - 55℃; for 2.5h; Product distribution / selectivity;
In ethanol; chloroform at 55℃;
In chloroform at 50 - 55℃; for 0.5h;

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) → (3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid (181289-33-8) + (S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid (181289-34-9)

Conditions	Yield
With (R)-1-phenyl-ethyl-amine Resolution of racemate;

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) → (S)‑3‑carbamoylmethyl‑5‑methylhexanoic acid (181289-34-9)

Conditions	Yield
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With (S)-1-phenyl-ethylamine In ethanol; chloroform for 0.75h; Reflux; Stage #2: With hydrogenchloride In ethanol; chloroform; water for 0.75h; Cooling;	16 g
Multi-step reaction with 2 steps 1: chloroform / 1.5 h / 55 °C 2: hydrogenchloride / water / pH 1 - 2 View Scheme

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + (S)-Mandelic acid (17199-29-0) → (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (S)-mandelate (185815-62-7)

Conditions	Yield
Stage #1: (±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid With bromine; sodium hydroxide In water at 5 - 50℃; Hofmann Reaction; Stage #2: (S)-Mandelic acid With hydrogenchloride In water at 20 - 22℃; pH=4.5 - 5.5; Heating;

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + 1-phenylpropylamine (2941-20-0) → R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt (1385049-51-3)

Conditions	Yield
In ethanol; chloroform at 60 - 63℃; for 0.75h;

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + (R)-1-phenyl-ethyl-amine (3886-69-9) → (3R)-3-(carbamoylmethyl)-5-methylhexanoic acid phenylethylamine

Conditions	Yield
In chloroform at 52.5℃; for 0.916667h;	367 g

(±)‑3‑(carbamoylmethyl)‑5‑methylhexanoic acid (181289-15-6) + (-)-menthol (2216-51-5) → C19H35NO3 + C19H35NO3

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Overall yield = 87.8 %;	A 1.436 g B 1.416 g

Upstream product

• 1634-04-4 tert-butyl methyl ether 
• 75143-89-4 5-methyl-3-carboxymethylhexanoic acid 
• 185815-59-2 3-isobutylglutaric anhydride 
• 916982-10-0 3-isobutylglutarimide 
• 181289-34-9 (S)?3?carbamoylmethyl?5?methylhexanoic acid 
• 590-86-3 isovaleraldehyde 
• 51615-30-6 diethyl 2-(3-methylbutylidene)malonate 
• 102710-09-8 2-isobutyl-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester 
• 1385049-46-6 (1'SR,3 SR)-1-(1'-napthyl)ethyl-3-(carboxylomethyl)-5-methylhexanoate 
• 185815-56-9 2,4-dicyano-3-isobutylglutaramide 
• 868-52-0 2?cyano?5?methylhex?2?enoic acid methyl ester 

Downstream Products

• 1001296-60-1 (S)-(+)-phenylglycinol salt of (S)-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid 
• 1001296-65-6 (R)-(-)-phenylglycinol salt of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 
• 148553-50-8 pregabilin 
• 128013-69-4 (R,S)-3-iso-butyl-4-aminobutyric acid 
• 181289-33-8 (3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid 
• 181289-34-9 (S)?3?carbamoylmethyl?5?methylhexanoic acid 
• 185815-62-7 (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (S)-mandelate 
• 1385049-51-3 R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt 
• 185815-61-6 (R)-3-(carbamoylmethyl)-5-methylhexanoic acid (R)-(+)-α-phenylethylamine 

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Pregregregabalin intermediate mother liquor and method for recycling wastewater

The invention provides a preparation method for mechanically applying Pregabalin 3-isobutyl-glutarate monoamide intermediate mother liquid and waste water. The method comprises the following steps: (1) dropwise adding 3-isobutyl glutaric anhydride into stronger ammonia water with the mass fraction of 25-28%, and carrying out insulation reaction; (2) adding reclaimed waste water into the system, and then dropwise adding acid slowly into the system to adjust the pH value to be 2.0-3.0; (3) adding the mother liquid into the system, extracting with an organic solvent for layering, and then carrying out reduced pressure distillation on an organic layer; and (4) cooling to 5-15 DEG C within 2-3 hours, crystallizing, insulating for 1.5-2 hours, carrying out suction filtration, preserving suction filtration mother liquid, and baking filter cakes, thereby obtaining the target product 3-isobutyl-glutarate monoamide. The method provided by the invention has the advantages that the operation is simple, and the ammonolysis yield is effectively improved; before the ammonolysis mother liquid is mechanically applied, the yield is generally 70-85%; and after the ammonolysis mother liquid is mechanically applied, the yield can reach 99.0-102.0%, so that the productivity is effectively enlarged, and the cost of industrial production is lowered.

Method for synthesizing optically pure (R)-3-carbamoymethyl-5-methylhexanoic acid

The invention relates to the technical field of fine chemical engineering production and in particular discloses a method for synthesizing optically pure (R)-3-carbamoymethyl-5-methylhexanoic acid. The method comprises the following steps: 1, synthesizing 2-cyano-5-methyl-2-ene ethyl hexanoate; 2, synthesizing 3-isobutyl-2-cyano-4-ethoxycarbonyl-ethyl glutarate; 3, synthesizing 3-isobutylglutaricanhydride; 4, synthesizing (+/-)-3-carbamoymethyl-5-methylhexanoic acid; and 5, synthesizing the (R)-3-carbamoymethyl-5-methylhexanoic acid. According to the method disclosed by the invention, the defects in the prior art are overcome, and the provided synthetic method is low in raw material cost, high in reaction speed, simple and feasible, is suitable for large-scale industrial production and has very high economic benefits.