High Quality Food Grade Natural Menthol Crystals Product Name Menthol crystal Appearance Colorless acicular crystal Odor with a characteristic mint aroma
Cas:2216-51-5
Min.Order:25 Kilogram
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inquiryOur Advantages Production: Advanced chemical equipment with years of experience Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Specif
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inquiry1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
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inquiryHanways focus on: -Pharmaceutical raw materials -Chemical raw materials -Food additives -Flavors and fragrances -Feed additives -Plant extracts -Veterinary raw materials We could supply you: -Best quality -Competitive price -Perfect ser
Cas:2216-51-5
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inquiryPRODUCT DETAILS L-Men
Cas:2216-51-5
Min.Order:500 Kilogram
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Type:Lab/Research institutions
inquiryDalian baijia import and export co., LTD., formerly known as xinyusheng chemical (Hong Kong) co., LTD., was founded in 2008. Its main business is fine chemical products and food additives. The company's main customers are distributed in Europe
Cas:2216-51-5
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryItems Standard Result Appearance Colorless transparent needle like crystal complies Aroma
Cas:2216-51-5
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Colorless transparent needle crystals Storage:-20°C Package:2
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:2216-51-5
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:2216-51-5
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s
Cas:2216-51-5
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:2216-51-5
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:L-Menthol CAS NO: 2216-51-5 Grade:Medical scientific research and export Molecular formula:C10H20O Molecular weight: 156.27 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data sto
Cas:2216-51-5
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FOB Price: $2.0 / 3.0
Type:Other
inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so
Cas:2216-51-5
Min.Order:100 Kilogram
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inquiryOur advantages: 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent out in 24 hours after payment.Tracking number available 2) Secure and disc
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:2216-51-5
Min.Order:10 Gram
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Type:Trading Company
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:2216-51-5
Min.Order:1 Gram
FOB Price: $1.0
Type:Manufacturers
inquiryAppearance:white crystal Storage:Room temperature Package:25kg/drum Application:Edible spices Transportation:Express/Sea/Air Port:Any port in china
Cas:2216-51-5
Min.Order:25 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:colorless, transparent hexagonal or needlelike crystals Stor
Cas:2216-51-5
Min.Order:100 Gram
Negotiable
Type:Other
inquirySuperiority Service we can provide: 1. Mixed container: We can mix different items in one container. 2. Quality control: Before shipment, we can provide free sample for test. Inspection before shipping. 3. Packing: We can pack according to you
Cas:2216-51-5
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:2216-51-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:2216-51-5
Min.Order:10 Gram
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Type:Trading Company
inquiryL-Menthol Basic information Product Name: L-Menthol Synonyms: (1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol;(1r,3r,4s)-(-)-mentho;(1R,3R,4S)-(-)-MENTHOL;(R)-(-)-Menthol;Emtricitabine Impurity 31;Natural Menthol Crystal;L
2216-51-5 L-Menthol Natural Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:colorless Storage:
Cas:2216-51-5
Min.Order:1 Metric Ton
Negotiable
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:2216-51-5
Min.Order:1 Kilogram
FOB Price: $15.0 / 20.0
Type:Trading Company
inquiryL-Menthol CAS:2216-51-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s
Cas:2216-51-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquirymenthyl allyl carbonate
(-)-menthol
Conditions | Yield |
---|---|
With diethylamine; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine In water for 0.5h; Ambient temperature; | 100% |
(1S,2R,4R)-(-)-2-tert-butoxy-1-isopropyl-4-methylcyclohexane
(-)-menthol
Conditions | Yield |
---|---|
With sodium iodide; cerium(III) chloride In acetonitrile at 70℃; for 2h; | 100% |
With cerium(III) chloride; sodium iodide In acetonitrile at 70℃; for 17h; |
menthyl allyl carbonate
2-propanethiol
A
allylisopropyl sulfide
B
carbon dioxide
C
(-)-menthol
Conditions | Yield |
---|---|
With Roussin's red salt ester; tetrabutylammomium bromide; potassium hydride In tetrahydrofuran; ethanol at 40℃; for 14h; | A n/a B n/a C 100% |
Conditions | Yield |
---|---|
With hydrogen In water at 80℃; under 7500.75 Torr; for 48h; Inert atmosphere; Autoclave; | 100% |
With 20percent 12-tungstophosphoric acid supported on MCM-41 In dichloromethane at 20℃; for 3h; Inert atmosphere; | |
Multi-step reaction with 2 steps 1: 0 - 5 °C 2: Raney nickel / 10 h / 70 °C / 18751.9 Torr / Inert atmosphere View Scheme | |
With hydrogen In water at 60℃; under 7500.75 Torr; for 23h; Catalytic behavior; Reagent/catalyst; Temperature; Autoclave; | 99 %Chromat. |
(-)-menthol
Conditions | Yield |
---|---|
With hydrogen In toluene at 100℃; under 22502.3 Torr; for 0.25h; Catalytic behavior; Pressure; Temperature; Reagent/catalyst; Flow reactor; | 99.9% |
With hydrogen; nickel; 4-methoxy-aniline In hexane at 80℃; under 30003 Torr; for 10h; Temperature; Pressure; Solvent; Autoclave; | 99.9% |
With ethanol; palladium on activated charcoal; sodium hydroxide; silicon at 20℃; for 72h; Schlenk technique; | 94% |
(2R,5S)-menthone
(-)-menthol
Conditions | Yield |
---|---|
With iron(II) chloride tetrahydrate; lithium In tetrahydrofuran; mineral oil at 20℃; for 4h; Reagent/catalyst; Inert atmosphere; stereoselective reaction; | 99% |
With tris(pentafluorophenyl)borate; hydrogen In diethyl ether at 70℃; under 45603.1 Torr; for 12h; Solvent; Glovebox; | 88% |
With sulfuric acid bei der elektrolytischen Reduktion; |
Conditions | Yield |
---|---|
With [Ru(2-(methylthio)-N-[(pyridin-2-yl)methyl]ethan-1-amine)(triphenylphosphine)Cl2]; potassium tert-butylate; hydrogen In toluene at 80℃; under 30003 Torr; for 3h; | 99% |
With ytterbium(III) triflate In isopropyl alcohol for 74h; Deacetylation; Heating; | 95% |
With sodium hydroxide In methanol; dichloromethane at 20℃; for 0.75h; Solvent; | 95% |
2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)tetrahydro-2H-pyran
(-)-menthol
Conditions | Yield |
---|---|
poly(4-vinylpyridinium) p-toluenesulfonate In tetrahydrofuran; ethanol at 75℃; for 45h; Hydrolysis; | 98% |
With trichloroisocyanuric acid In methanol at 20℃; for 4h; | 94% |
With tris-(4-bromophenyl)aminium hexachloroantimonate In methanol at 20℃; for 2.5h; | 93% |
4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether
(-)-menthol
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid; 1,3-Dimethoxybenzene In dichloromethane at 21℃; for 0.166667h; | 98% |
With trifluorormethanesulfonic acid; toluene-4-sulfonamide In diethyl ether | 95% |
With silver hexafluoroantimonate; 1,2,3-trimethoxybenzene In dichloromethane at 40℃; for 2.5h; | 93% |
(1S,2R,4R)-2-(allyloxy)-1-isopropyl-4-methylcyclohexane
(-)-menthol
Conditions | Yield |
---|---|
With diisobutylaluminium hydride; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In diethyl ether; toluene at 0 - 20℃; for 3h; | 97% |
Stage #1: (1S,2R,4R)-2-(allyloxy)-1-isopropyl-4-methylcyclohexane; Grubbs catalyst first generation In dichloromethane at 20℃; for 12h; Stage #2: With hydrogenchloride | 95% |
With triisopropoxytitanium(IV) chloride; n-butyl magnesium bromide In tetrahydrofuran; diethyl ether; hexane for 2h; Ambient temperature; | 94% |
tert-butyl(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)dimethylsilane
(-)-menthol
Conditions | Yield |
---|---|
With iodine In methanol for 4h; Ambient temperature; | 97% |
With hafnium tetrakis(trifluoromethanesulfonate) In methanol at 20℃; for 6h; | 96% |
With hafnium tetrakis(trifluoromethanesulfonate) In methanol at 20℃; for 6h; | 96% |
(1S,2S,6R,7R,8R)-9-[1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxycarbonyl)-meth-(Z)-ylidene]-4,4-dimethyl-3,5-dioxa-tricyclo[5.2.1.02,6]decane-8-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
A
(-)-menthol
B
2-[(1R,2R,6S,7S,9R)-9-Hydroxymethyl-4,4-dimethyl-3,5-dioxa-tricyclo[5.2.1.02,6]dec-(8E)-ylidene]-ethanol
Conditions | Yield |
---|---|
With diisobutylaluminium hydride In dichloromethane at -78 - 0℃; | A 96% B 93% |
2-{[(tert-butyl)dimethylsilyl]oxy}-4-methyl-1-(1-methylethyl)cyclohexane
(-)-menthol
Conditions | Yield |
---|---|
With cerium (IV) sulfate tetrahydrate In methanol at 130℃; for 0.333333h; Microwave irradiation; | 96% |
menthyl hydrogen phthalate
(-)-menthol
Conditions | Yield |
---|---|
With hydroxide solution at 15℃; for 5h; | 96% |
(1R,3R,4S)-p-menth-3-yl (R)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate
A
(-)-menthol
B
(R)-6,7-Dichloro-2,3-dihydro-benzofuran-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In acetonitrile for 17h; Ambient temperature; | A 95% B 515 mg |
acetaldehyde ethyl menthyl acetal
(-)-menthol
Conditions | Yield |
---|---|
With acetonyltriphenylphosphonium bromide In methanol; dichloromethane at 20℃; for 0.25h; | 95% |
With CuCl2*H2O In water; acetone for 1h; Hydrolysis; Heating; | 91% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; cerium(III) chloride In methanol for 0.0833333h; Yields of byproduct given; | A 94% B n/a |
With methanol; sodium tetrahydroborate at 20℃; | A 50% B 31% |
With sodium tetrahydroborate In isopropyl alcohol Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
methoxyethoxymethyl ether of menthol
(-)-menthol
Conditions | Yield |
---|---|
With cerium(III) chloride In acetonitrile for 1.5h; Heating; | 94% |
4-(2-isopropyl-5-methyl-cyclohexyloxymethyl)-phenol
(-)-menthol
Conditions | Yield |
---|---|
With iron(III) chloride In diethyl ether; dichloromethane | 94% |
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl picolinate
(-)-menthol
Conditions | Yield |
---|---|
With zinc diacetate In methanol; dichloromethane at 38℃; for 3.8h; | 94% |
With methanol; copper diacetate In chloroform at 20℃; for 6h; Inert atmosphere; | 91% |
Conditions | Yield |
---|---|
With 3-azapentane-1,5-diamine at 160℃; for 0.5h; Sealed tube; Microwave irradiation; | 94% |
methanol
(1R,3R,4S)-p-menth-3-yl (R)-6,7-dichloro-2,3-dibenzofuran-2-carboxylate
A
(-)-menthol
B
methyl (R)-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid for 20h; Heating; | A 81% B 93% |
(-)-menthol
Conditions | Yield |
---|---|
With indium; ammonium chloride In methanol for 18h; Heating; | 93% |
(-)-menthol
Conditions | Yield |
---|---|
With carbon tetrabromide In methanol Irradiation; | 93% |
(-)-menthol
Conditions | Yield |
---|---|
With sodium methylate In methanol; diethyl ether at 20℃; | 93% |
[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]methyl]benzene
A
(-)-menthol
B
benzoic acid
Conditions | Yield |
---|---|
With bis(acetylacetonate)oxovanadium; methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate at 120℃; for 48h; | A 90% B 93% |
(1S,2R,4R)-1-isopropyl-4-methyl-2-(3-methylbut-2-en-1-yloxy)cyclohexane
(-)-menthol
Conditions | Yield |
---|---|
With iodine In dichloromethane at 20℃; for 1h; | 92% |
With 3 A molecular sieve; iodine In dichloromethane at 0 - 20℃; for 1h; | 92% |
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 20℃; for 1.5h; | 86% |
With sodium iodide; zirconium(IV) chloride In acetonitrile for 1.5h; Heating; | 86% |
(1S,2R,4S)-1-isopropyl-4-methyl-2-trityloxy-cyclohexane
(-)-menthol
Conditions | Yield |
---|---|
With bismuth(III) chloride In acetonitrile at 20℃; for 0.0833333h; | 92% |
(1R,2S,5R)-menthyl 2-(prenyloxymethyl)benzoate
(-)-menthol
Conditions | Yield |
---|---|
Stage #1: (1R,2S,5R)-menthyl 2-(prenyloxymethyl)benzoate With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 20℃; for 6h; Stage #2: With ytterbium(III) triflate In dichloromethane at 20℃; for 3h; | 92% |
(-)-menthol
(2R,5S)-menthone
Conditions | Yield |
---|---|
With Dess-Martin periodane In dichloromethane at 20℃; for 4h; | 100% |
With 1,3,5,7-tetrakis-(4-(diacetoxyiodo)phenyl)adamantane; potassium bromide In water at 20℃; for 4h; | 100% |
With ruthenium trichloride; iodobenzene; potassium peroxomonosulfate In water; acetonitrile at 20℃; for 0.5h; | 100% |
(-)-menthol
dimenthyl sulfite
Conditions | Yield |
---|---|
With 1,2,3-Benzotriazole; thionyl chloride In dichloromethane at 20℃; Substitution; | 100% |
With thionyl chloride; triethylamine In dichloromethane at -60℃; | 95% |
With pyridine; diethyl ether; chlorosulfurous acid |
(-)-menthol
ethyl 3-oxo-3-phenylpropionate
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-oxo-3-phenylpropanoate
Conditions | Yield |
---|---|
at 100℃; for 8h; | 100% |
With N-Bromosuccinimide In toluene at 90 - 100℃; for 4h; | 77% |
at 120℃; | |
at 160℃; | |
With dmap Dean-Stark; Reflux; |
(-)-menthol
phenyl isocyanate
phenylcarbamic acid (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ester
Conditions | Yield |
---|---|
With MoCl2O2(dmf)2 In dichloromethane at 20℃; for 0.333333h; | 100% |
With MoCl2O2(dmf)2 In dichloromethane at 20℃; for 0.333333h; Reagent/catalyst; Inert atmosphere; Sealed tube; | 100% |
Conditions | Yield |
---|---|
With 1-[bis(trifluoromethanesulfonyl)methyl]-2,3,4,5,6-pentafluorobenzene | 100% |
With 4-(1H,1H-perfluorotetradecyl)-C6F4-CH(SO2CF3)2 In toluene at 70℃; for 14h; | 99% |
With 4-(dimethylamino)pyridine hydrochloride In toluene at 60℃; for 6h; | 98% |
(-)-menthol
chloroacetyl chloride
(-)-menthyl chloroacetate
Conditions | Yield |
---|---|
In benzene Heating; | 100% |
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 12h; Temperature; | 98.8% |
for 5.5h; Reflux; | 95% |
(-)-menthol
2-Bromoacetyl bromide
(1R,2S,5R)-menthol bromoacetate
Conditions | Yield |
---|---|
With pyridine In dichloromethane at -78℃; Inert atmosphere; | 100% |
With potassium carbonate In dichloromethane at 0 - 20℃; Inert atmosphere; | 95% |
With N,N-dimethyl-aniline In diethyl ether 1.) 0 deg C, 3 h, 2.) reflux, 3 h; | 77% |
(-)-menthol
bromoacetic acid
(1R,2S,5R)-menthol bromoacetate
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 3h; | 100% |
With dmap; dicyclohexyl-carbodiimide at 100℃; for 3h; | 96% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 2h; | 91% |
(-)-menthol
Propiolic acid
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl propiolate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene Reflux; Dean-Stark; | 100% |
With sulfuric acid | |
With sulfuric acid for 216h; Ambient temperature; | |
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 25℃; for 6h; |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 3h; | 100% |
With sodium acetate In acetonitrile for 2h; Heating; | 96% |
With triethylamine In acetone for 2h; Heating; | 92% |
Conditions | Yield |
---|---|
With pyridine; dmap In dichloromethane at 0℃; | 100% |
With pyridine In toluene for 14h; Ambient temperature; | 89% |
diethylphosphonoacetic acid
(-)-menthol
(diethoxy-phosphoryl)-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate; toluene at 20℃; Inert atmosphere; | 100% |
With triethylamine; 2-chloropyridinium iodide |
oxalyl dichloride
(-)-menthol
2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoacetic acid
Conditions | Yield |
---|---|
Stage #1: oxalyl dichloride; (-)-menthol In diethyl ether at 0 - 23℃; for 1.5h; Inert atmosphere; Stage #2: With water In diethyl ether at 0 - 23℃; Inert atmosphere; | 100% |
1) CH2Cl2, room temperature, 2) hydrolysis; Multistep reaction; | |
In diethyl ether; dichloromethane at 0 - 20℃; for 18h; |
trans-chrotonyl chloride
(-)-menthol
l-menthyl 3-butenoate
Conditions | Yield |
---|---|
With triethylamine at 0℃; | 100% |
3-(trimethylsilyl)propanoyl chloride
(-)-menthol
3-trimethylsilanyl-propionic acid-((1R)-menthyl ester)
Conditions | Yield |
---|---|
With pyridine | 100% |
bis(trichloromethyl) carbonate
(-)-menthol
(1R,2S,5R)-menthyl chloroformate
Conditions | Yield |
---|---|
With pyridine In tetrachloromethane at 55 - 60℃; for 6h; | 100% |
Stage #1: bis(trichloromethyl) carbonate With pyridine In toluene at 0℃; for 0.25h; Inert atmosphere; Stage #2: (-)-menthol In toluene at 20℃; for 15h; Inert atmosphere; | 100% |
Stage #1: bis(trichloromethyl) carbonate With pyridine In toluene at 0℃; Inert atmosphere; Stage #2: (-)-menthol In toluene at 0 - 20℃; Inert atmosphere; | 100% |
(-)-menthol
(E)-2-oxo-4-phenyl-3-butenoic acid
2-oxo-4-phenylbut-3-enoic acid 2-isopropyl-5-methylcyclohexyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 5h; Heating; | 100% |
With toluene-4-sulfonic acid In toluene for 3h; Heating; | 79% |
With toluene-4-sulfonic acid In toluene Heating; | 79% |
(-)-menthol
benzene
<<(-)-menthyloxy>(tosyloxy)iodo>benzene
Conditions | Yield |
---|---|
In dichloromethane | 100% |
(-)-menthol
(1S,2S,4R)-2-bromo-1-isopropyl-4-methylcyclohexane
Conditions | Yield |
---|---|
With carbon tetrabromide; tris[4-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctyloxy)phenyl]phosphane In toluene at 50℃; for 4h; | 100% |
With 1-bromo-N,N,2-trimethyl-1-propen-1-amine; methyloxirane In dichloromethane 1.) -78 deg C to r.t., 2.) r.t., overnight; | 97% |
With bromine; triethylamine; triphenylphosphine at 20℃; for 1.5h; Substitution; | 86% |
With chloro-trimethyl-silane; lithium bromide In acetonitrile for 20h; Heating; | 72% |
With 4-methylurazole; methyl bromide; triphenylphosphine 1) THF, 0 deg C, 2) room temperature, 6 h; Yield given. Multistep reaction; |
(-)-menthol
(1R,2S,5R)-(-)-menthyl phosphorodichloridite
Conditions | Yield |
---|---|
With phosphorus trichloride In tetrahydrofuran for 1h; Ambient temperature; | 100% |
With phosphorus trichloride Inert atmosphere; | 98% |
Stage #1: (-)-menthol With sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: With phosphorus trichloride In tetrahydrofuran Inert atmosphere; | 64% |
(-)-menthol
methanesulfonyl chloride
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl methanesulfonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 16h; Inert atmosphere; Schlenk technique; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 12h; | 100% |
With 1-methyl-1H-imidazole; triethylamine In toluene at 20 - 25℃; for 1h; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
Stage #1: (-)-menthol With n-butyllithium In tetrahydrofuran; hexane at 0℃; Inert atmosphere; Stage #2: Dichlorophenylphosphine In tetrahydrofuran; hexane at -78 - 20℃; for 15h; Inert atmosphere; | 100% |
With R3N | |
With pyridine |
Conditions | Yield |
---|---|
With trifluoroacetic acid at 20℃; for 96h; | 100% |
With acetonyltriphenylphosphonium bromide In dichloromethane at 20℃; for 0.0833333h; | 99% |
With acetonyltriphenylphosphonium bromide In dichloromethane for 0.0833333h; Ambient temperature; | 92% |
With hydrogenchloride |
Conditions | Yield |
---|---|
zeolite HSZ-360 In neat (no solvent) at 60℃; for 1h; Product distribution; direct acetylation of phenols and alcohols, catalyst reusable without activity loss; | 100% |
zeolite HSZ-360 In neat (no solvent) at 60℃; for 1h; | 100% |
With polystyrene-bound tetrafluorophenylbis(triflyl)methane | 100% |
Conditions | Yield |
---|---|
With methanesulfonic acid at 30 - 35℃; for 2h; | 100% |
With copper(II) nitrate for 3.5h; Heating; | 98% |
LaY zeolite at 116℃; for 10h; Acetylation; | 98% |
Conditions | Yield |
---|---|
With copper(II) nitrate for 3.5h; Heating; | 100% |
With bismuth(III) chloride for 1h; Heating; | 95% |
With Silphos at 20℃; for 1h; | 94% |
3-ethoxy-2-methylacrolein
(-)-menthol
3-[2-isopropyl-5-methylcyclohexyloxy-(1R,2S,5R)]-2-methyl-2E-propenal
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid under 23 Torr; for 24h; Substitution; | 100% |
(-)-menthol
(S)-chlorofluoroacetic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Esterification; Title compound not separated from byproducts; | 100% |
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