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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Erlotinib Manufacturer/High quality/Best price/In stock

Cas:183321-74-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ---------------------------------------------------------------------------------------------

High purity Various Specifications Erlotinib CAS:183321-74-6

Cas:183321-74-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Erlotinib Base supplier in China

Cas:183321-74-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Erlotinib CAS 183321-74-6 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing t

Erlotinib CAS 183321-74-6

Cas:183321-74-6

Min.Order:10 Gram

FOB Price: $50.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Erlotinib[CAS:183321-74-6] 3-Aminophenylacetylene[CAS:54060-30-9] 2-Bromoethyl Methyl Ether[CAS:6482-24-2] 3-Aminophenylacetylene HCL[CAS:207726-02-6] 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline[CAS:183322-18-1] 6,7-Bis-(2-methoxye

Good supply Erlotinib API and intermediate

Cas:183321-74-6

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Erlotinib Base

Cas:183321-74-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Erlotinib 183321-74-6 ISO Producer

Cas:183321-74-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

CAS:183321-74-6/High quality/Factory supply

Cas:183321-74-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Erlotinib

Cas:183321-74-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Erlotinib

Cas:183321-74-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

erlotinib

Cas:183321-74-6

Min.Order:1000 Gram

FOB Price: $3000.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:Erlotinib The alias:4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazolin CAS NO: 183321-74-6 Molecular formula:C22H23N3O4 Molecular weight:393.44 Product Quality 12 years of chemical raw materials Mature operation of the industry

Erlotinib/CAS:183321-74-6/Raw material supply

Cas:183321-74-6

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

183321-74-6 Erlotinib

Cas:183321-74-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 183321-74-6 Pharmaceutical Intermediate Erlotinib

Cas:183321-74-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 183321-74-6 with competitive price

Cas:183321-74-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pudo

183321-74-6/Erlotinib

Cas:183321-74-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Henan Sinotech Import&Export Corporation

Erlotinib (OSI-744; NSC 718781; R1415) is an EGFR inhibitor . Chemical Properties: Cas No. 183321-74-6 Storage Please store the product under the recommended conditions

Erlotinib 183321-74-6

Cas:183321-74-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

183321-74-6 Erlotinib Manufacturer Anticancer Agents

Cas:183321-74-6

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Erlotinib 183321-74-6

Cas:183321-74-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Faithful Supply 99% Erlotinib / ERLOTINIB HCL / ERLOTINIB HCL SALT 100% Safe Customs Clearance

Cas:183321-74-6

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

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HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Erlotinib CAS 183321-74-6

Cas:183321-74-6

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Product Name: Erlotinib Synonyms: ERLOTINIB;ERLOTINIB HCL;ERLOTINIB HCL SALT;4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline;n-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine;Erlotinib Hydrochloirde;4-Quinazolinam

Erlotinib

Cas:183321-74-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antitumor drugs Erlotinib with CAS:183321-74-6

Cas:183321-74-6

Min.Order:1 Kilogram

FOB Price: $1108.0 / 1258.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Erlotinib CAS: 183321-74-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Erlotinib CAS: 183321-74-6

Cas:183321-74-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Erlotinib

Cas:183321-74-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Erlotinib/ LIDE PHARMA- Factory supply / Best price

Cas:183321-74-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Top quality Erlotinib with best price

Cas:183321-74-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Erlotinib CAS: 183321-74-6 Specification APPEARANCE ALMOST WHITE TO PALE YELLOW POWDER CONFORM IDENTIFICATION H-NMR MS CONFORM LOSS ON DRYING &

Factory supply Erlotinib

Cas:183321-74-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Erlotinib

Cas:183321-74-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

Nanjing Fred Technology Co., Ltd is a high-tech enterprise engaged in the R&D, production and sales of pharmaceutical intermediates. With our own R&D center and production sites, we specialize in the kg to hundred kgs scale synthesis of compl

Factory Supply High Quality Erlotinib CAS NO.183321-74-6

Cas:183321-74-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
In isopropyl alcohol Concentration; Reflux;96.6%
In isopropyl alcohol Temperature; Reflux;96.6%
In isopropyl alcohol at 20℃; Concentration; Temperature; Reflux;96.6%
erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
With sodium hydroxide In water pH=5 - 12; Product distribution / selectivity;96.3%
With ammonia In water for 2h; pH=9.4; Product distribution / selectivity;94.3%
With sodium hydroxide In water; ethyl acetate at 20℃; Product distribution / selectivity;
N′-[2-cyano-4,5-{bis(2-methoxyethoxy)phenyl}]-N,N-dimethylformamidine
950596-59-5

N′-[2-cyano-4,5-{bis(2-methoxyethoxy)phenyl}]-N,N-dimethylformamidine

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
With acetic acid In N,N-dimethyl-formamide at 125℃; for 1h;91.5%
With acetic acid In toluene at 125 - 130℃;66%
With acetic acid at 125 - 130℃; for 3h;66%
Stage #1: N′-[2-cyano-4,5-{bis(2-methoxyethoxy)phenyl}]-N,N-dimethylformamidine; 3-acetylenephenylamine With acetic acid at 125℃; for 3h;
Stage #2: With sodium hydrogencarbonate In water at 0℃;
2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile
950596-58-4

2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile

(E)-N,N'-bis(3-ethynylphenyl)methyl ether

(E)-N,N'-bis(3-ethynylphenyl)methyl ether

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 110℃; for 5h; Temperature; Solvent;88.2%
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
With titanium tetrachloride; methoxybenzene In 1,4-dioxane for 4h; Inert atmosphere; Reflux;82%
Stage #1: 6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one With triethylamine; trichlorophosphate In toluene at 20 - 65℃; Inert atmosphere;
Stage #2: 3-acetylenephenylamine In isopropyl alcohol; toluene for 2.5h; Inert atmosphere;
64%
6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline
1312937-41-9

6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Stage #1: 3-acetylenephenylamine In tetrahydrofuran; toluene at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; toluene at 20℃; for 4h; Product distribution / selectivity;
70%
Stage #1: 3-acetylenephenylamine With n-butyllithium In tetrahydrofuran; toluene at 0℃; Inert atmosphere;
Stage #2: 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline In tetrahydrofuran; toluene at 0 - 20℃; for 4.16667h; Product distribution / selectivity;
70%
3,4-bis(2-methoxyethoxy) benzonitrile
80407-68-7

3,4-bis(2-methoxyethoxy) benzonitrile

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: nitric acid / acetic acid / 4 h / 0 °C
2.1: sodium dithionite / water / 3 h / 50 °C
2.2: 0.5 h / 65 °C
3.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
4.1: acetic acid / toluene / 5 h / 60 °C
5.1: toluene / 5 h / 125 °C
View Scheme
Multi-step reaction with 4 steps
1.1: nitric acid / acetic acid / 4 h / 0 °C
2.1: sodium dithionite / water / 3 h / 50 °C
2.2: 0.5 h / 65 °C
3.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
4.1: acetic acid / toluene / 125 - 130 °C
View Scheme
Multi-step reaction with 4 steps
1.1: acetic acid / 20 °C
1.2: 5 - 55 °C
2.1: palladium on activated charcoal; hydrogen / ethanol / 2.5 h / 20 °C / 2585.81 Torr
3.1: 3 h / 20 °C / Reflux
4.1: acetic acid / 2 h / Reflux
View Scheme
2-nitro-4,5-bis(2-methoxyethoxy)benzonitrile
236750-65-5

2-nitro-4,5-bis(2-methoxyethoxy)benzonitrile

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium dithionite / water / 3 h / 50 °C
1.2: 0.5 h / 65 °C
2.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
3.1: acetic acid / toluene / 5 h / 60 °C
4.1: toluene / 5 h / 125 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium dithionite / water / 3 h / 50 °C
1.2: 0.5 h / 65 °C
2.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
3.1: acetic acid / toluene / 125 - 130 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium dithionite / water / 2.5 h / 50 °C
2: acetic acid / toluene / 3 h / 105 °C / Dean-Stark
3: acetic acid / 3 h / 125 - 130 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrazine hydrate / water / 3 h / 20 - 30 °C
2: trifluoroacetic acid / ethyl acetate / 4 h / Reflux
3: trichlorophosphate; N,N-dimethyl-formamide / ethyl acetate / 2 h / 70 °C / Inert atmosphere
4: ethanol / 3 h / 40 - 70 °C
View Scheme
Multi-step reaction with 3 steps
1: palladium on activated charcoal; hydrogen / ethanol / 2.5 h / 20 °C / 2585.81 Torr
2: 3 h / 20 °C / Reflux
3: acetic acid / 2 h / Reflux
View Scheme
C24H30N4O4

C24H30N4O4

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
In toluene at 125℃; for 5h;47 g
methoxyethoxy 3,4-bis(2-methoxyethoxy)-benzoate

methoxyethoxy 3,4-bis(2-methoxyethoxy)-benzoate

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: water; potassium hydroxide / methanol / 4 h / 20 °C
2.1: urea / 0.5 h / 220 °C
3.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux
4.1: nitric acid / acetic acid / 4 h / 0 °C
5.1: sodium dithionite / water / 3 h / 50 °C
5.2: 0.5 h / 65 °C
6.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
7.1: acetic acid / toluene / 5 h / 60 °C
8.1: toluene / 5 h / 125 °C
View Scheme
Multi-step reaction with 7 steps
1.1: water; potassium hydroxide / methanol / 4 h / 20 °C
2.1: urea / 0.5 h / 220 °C
3.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux
4.1: nitric acid / acetic acid / 4 h / 0 °C
5.1: sodium dithionite / water / 3 h / 50 °C
5.2: 0.5 h / 65 °C
6.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
7.1: acetic acid / toluene / 125 - 130 °C
View Scheme
3,4-bis(2-methoxyethoxy)-benzamide
1418289-91-4

3,4-bis(2-methoxyethoxy)-benzamide

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux
2.1: nitric acid / acetic acid / 4 h / 0 °C
3.1: sodium dithionite / water / 3 h / 50 °C
3.2: 0.5 h / 65 °C
4.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
5.1: acetic acid / toluene / 5 h / 60 °C
6.1: toluene / 5 h / 125 °C
View Scheme
Multi-step reaction with 5 steps
1.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux
2.1: nitric acid / acetic acid / 4 h / 0 °C
3.1: sodium dithionite / water / 3 h / 50 °C
3.2: 0.5 h / 65 °C
4.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
5.1: acetic acid / toluene / 125 - 130 °C
View Scheme
3,4-bis(2-methoxyethoxy)-benzoic acid
819813-71-3

3,4-bis(2-methoxyethoxy)-benzoic acid

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: urea / 0.5 h / 220 °C
2.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux
3.1: nitric acid / acetic acid / 4 h / 0 °C
4.1: sodium dithionite / water / 3 h / 50 °C
4.2: 0.5 h / 65 °C
5.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
6.1: acetic acid / toluene / 5 h / 60 °C
7.1: toluene / 5 h / 125 °C
View Scheme
Multi-step reaction with 6 steps
1.1: urea / 0.5 h / 220 °C
2.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux
3.1: nitric acid / acetic acid / 4 h / 0 °C
4.1: sodium dithionite / water / 3 h / 50 °C
4.2: 0.5 h / 65 °C
5.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
6.1: acetic acid / toluene / 125 - 130 °C
View Scheme
Multi-step reaction with 10 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: triethylamine; dmap / dichloromethane / 24 h / 20 °C
4: sodium hydroxide / methanol / 2 h / 20 °C
5: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
6: sodium hydroxide / ethanol / 20 °C
7: ethanol / 1 h / Reflux
8: hydrogenchloride / water / 2 h / 100 - 105 °C
9: trichlorophosphate / toluene / 4 h / Reflux
10: pyridine / isopropyl alcohol / 4 h / Reflux
View Scheme
2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile
950596-58-4

2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
2: acetic acid / toluene / 5 h / 60 °C
3: toluene / 5 h / 125 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid / toluene / 3 h / 105 °C / Dean-Stark
2: acetic acid / 3 h / 125 - 130 °C
View Scheme
N′-[2-cyano-4,5-{bis(2-methoxyethoxy)phenyl}]-N,N-dimethylformamidine
950596-59-5

N′-[2-cyano-4,5-{bis(2-methoxyethoxy)phenyl}]-N,N-dimethylformamidine

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid / toluene / 5 h / 60 °C
2: toluene / 5 h / 125 °C
View Scheme
3,4-Dihydroxybenzoic acid
99-50-3

3,4-Dihydroxybenzoic acid

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C
1.2: 50 - 85 °C
2.1: water; potassium hydroxide / methanol / 4 h / 20 °C
3.1: urea / 0.5 h / 220 °C
4.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux
5.1: nitric acid / acetic acid / 4 h / 0 °C
6.1: sodium dithionite / water / 3 h / 50 °C
6.2: 0.5 h / 65 °C
7.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
8.1: acetic acid / toluene / 5 h / 60 °C
9.1: toluene / 5 h / 125 °C
View Scheme
Multi-step reaction with 8 steps
1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C
1.2: 50 - 85 °C
2.1: water; potassium hydroxide / methanol / 4 h / 20 °C
3.1: urea / 0.5 h / 220 °C
4.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 18 h / Reflux
5.1: nitric acid / acetic acid / 4 h / 0 °C
6.1: sodium dithionite / water / 3 h / 50 °C
6.2: 0.5 h / 65 °C
7.1: acetic acid; N,N-dimethyl-formamide dimethyl acetal / toluene / 4 h / 105 °C
8.1: acetic acid / toluene / 125 - 130 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sulfuric acid / 10 h / 40 - 80 °C
2.1: potassium tert-butylate; potassium iodide / N,N-dimethyl-formamide / 12 h / 100 °C
3.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness
4.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C
4.2: 20 °C
5.1: ammonium formate; triethylamine / 6 h / 160 °C
6.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C
7.1: methanol / 3 h / 20 - 30 °C
7.2: 3 h / 50 °C
View Scheme
Ethyl protocatechuate
3943-89-3

Ethyl protocatechuate

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C
2: potassium hydroxide / ethanol; water / 3 h / 20 °C
3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C
4: triethylamine / dichloromethane / 0 - 20 °C
5: triethylamine; dmap / dichloromethane / 24 h / 20 °C
6: sodium hydroxide / methanol / 2 h / 20 °C
7: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
8: sodium hydroxide / ethanol / 20 °C
9: ethanol / 1 h / Reflux
10: hydrogenchloride / water / 2 h / 100 - 105 °C
11: trichlorophosphate / toluene / 4 h / Reflux
12: pyridine / isopropyl alcohol / 4 h / Reflux
View Scheme
Multi-step reaction with 6 steps
1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetone / 64 h / Inert atmosphere; Reflux
2: acetic acid; nitric acid / 24 h / 5 °C
3: hydrogenchloride; hydrogen; platinum(IV) oxide hydrate / water; ethanol / 6 h / 2327.23 Torr
4: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere
5: pyridine; trichlorophosphate / 2.5 h / Inert atmosphere
6: pyridine / isopropyl alcohol / 4 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetone / 64 h / Inert atmosphere; Reflux
2: acetic acid; nitric acid / 24 h / 5 °C
3: hydrogenchloride; hydrogen; platinum(IV) oxide hydrate / water; ethanol / 6 h / 2327.23 Torr
4: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere
5: oxalyl dichloride; N,N-dimethyl-formamide / methanol / 1.5 h / Reflux
6: pyridine / isopropyl alcohol / 4 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1.1: potassium tert-butylate; potassium iodide / N,N-dimethyl-formamide / 12 h / 100 °C
2.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness
3.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C
3.2: 20 °C
4.1: ammonium formate; triethylamine / 6 h / 160 °C
5.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C
6.1: methanol / 3 h / 20 - 30 °C
6.2: 3 h / 50 °C
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: potassium hydroxide / ethanol; water / 3 h / 20 °C
2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C
3: triethylamine / dichloromethane / 0 - 20 °C
4: triethylamine; dmap / dichloromethane / 24 h / 20 °C
5: sodium hydroxide / methanol / 2 h / 20 °C
6: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
7: sodium hydroxide / ethanol / 20 °C
8: ethanol / 1 h / Reflux
9: hydrogenchloride / water / 2 h / 100 - 105 °C
10: trichlorophosphate / toluene / 4 h / Reflux
11: pyridine / isopropyl alcohol / 4 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: acetic acid; nitric acid / 24 h / 5 °C
2: hydrogenchloride; hydrogen; platinum(IV) oxide hydrate / water; ethanol / 6 h / 2327.23 Torr
3: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere
4: pyridine; trichlorophosphate / 2.5 h / Inert atmosphere
5: pyridine / isopropyl alcohol / 4 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: acetic acid; nitric acid / 24 h / 5 °C
2: hydrogenchloride; hydrogen; platinum(IV) oxide hydrate / water; ethanol / 6 h / 2327.23 Torr
3: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere
4: oxalyl dichloride; N,N-dimethyl-formamide / methanol / 1.5 h / Reflux
5: pyridine / isopropyl alcohol / 4 h / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness
2.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C
2.2: 20 °C
3.1: ammonium formate; triethylamine / 6 h / 160 °C
4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C
5.1: methanol / 3 h / 20 - 30 °C
5.2: 3 h / 50 °C
View Scheme
C13H17ClO5

C13H17ClO5

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: triethylamine; dmap / dichloromethane / 24 h / 20 °C
3: sodium hydroxide / methanol / 2 h / 20 °C
4: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
5: sodium hydroxide / ethanol / 20 °C
6: ethanol / 1 h / Reflux
7: hydrogenchloride / water / 2 h / 100 - 105 °C
8: trichlorophosphate / toluene / 4 h / Reflux
9: pyridine / isopropyl alcohol / 4 h / Reflux
View Scheme
C15H23NO6

C15H23NO6

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: triethylamine; dmap / dichloromethane / 24 h / 20 °C
2: sodium hydroxide / methanol / 2 h / 20 °C
3: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
4: sodium hydroxide / ethanol / 20 °C
5: ethanol / 1 h / Reflux
6: hydrogenchloride / water / 2 h / 100 - 105 °C
7: trichlorophosphate / toluene / 4 h / Reflux
8: pyridine / isopropyl alcohol / 4 h / Reflux
View Scheme
2-(3,4-bis(2-methoxyethoxy)phenyl)-4,5-dihydro-oxazole

2-(3,4-bis(2-methoxyethoxy)phenyl)-4,5-dihydro-oxazole

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
2: sodium hydroxide / ethanol / 20 °C
3: ethanol / 1 h / Reflux
4: hydrogenchloride / water / 2 h / 100 - 105 °C
5: trichlorophosphate / toluene / 4 h / Reflux
6: pyridine / isopropyl alcohol / 4 h / Reflux
View Scheme
C17H21F3N2O6

C17H21F3N2O6

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium hydroxide / ethanol / 20 °C
2: ethanol / 1 h / Reflux
3: hydrogenchloride / water / 2 h / 100 - 105 °C
4: trichlorophosphate / toluene / 4 h / Reflux
5: pyridine / isopropyl alcohol / 4 h / Reflux
View Scheme
erlotinib
183321-74-6

erlotinib

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol at 0℃; for 1h; Product distribution / selectivity; Inert atmosphere;100%
With hydrogenchloride In ethanol; water at 72℃; for 0.333333h; Solvent; Temperature;99%
With hydrogenchloride In water; acetone at 10℃; for 2.5h; Solvent; Temperature;98.7%
erlotinib
183321-74-6

erlotinib

N‐(3‐ethynylphenyl)‐6,7‐bis(2‐methoxyethoxy)quinazolin‐4‐amine hydrochloride

N‐(3‐ethynylphenyl)‐6,7‐bis(2‐methoxyethoxy)quinazolin‐4‐amine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; dichloromethane at 15 - 30℃; for 3.08333h; Product distribution / selectivity;100%
With hydrogenchloride In 1,4-dioxane; isopropyl alcohol at 0 - 70℃; for 1.5h; Solvent; Temperature;97.2%
With hydrogenchloride In water; butanone at 30 - 35℃;93.13%
With hydrogenchloride In isopropyl alcohol at 20 - 65℃; for 1h; Time; Concentration;30.0 g
With hydrogenchloride In diethyl ether; chloroform90 mg
dichloro-acetic acid
79-43-6

dichloro-acetic acid

erlotinib
183321-74-6

erlotinib

erlotinib dichloroacetate
1355242-84-0

erlotinib dichloroacetate

Conditions
ConditionsYield
In isopropyl alcohol at 20 - 25℃; for 0.0416667h; Product distribution / selectivity;95.43%
3,3-difluoro-2-iododec-1-ene

3,3-difluoro-2-iododec-1-ene

erlotinib
183321-74-6

erlotinib

N-(3-(4,4-difluoro-3-methyleneundec-1-yn-1-yl)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine

N-(3-(4,4-difluoro-3-methyleneundec-1-yn-1-yl)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine

Conditions
ConditionsYield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 40℃; for 48h; Inert atmosphere;95%
2-[2-(2-azidoethoxy)ethoxy]ethanol
86520-52-7

2-[2-(2-azidoethoxy)ethoxy]ethanol

erlotinib
183321-74-6

erlotinib

C28H36N6O7
1454772-95-2

C28H36N6O7

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In ethanol; water at 20℃; for 24h;93%
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; ethanol; water at 20℃; for 24h;93%
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; water; tert-butyl alcohol at 40℃; for 5h; Inert atmosphere;54%
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; water; tert-butyl alcohol at 60℃; for 3h; Inert atmosphere;
2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol
86770-67-4

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol

erlotinib
183321-74-6

erlotinib

C30H40N6O8

C30H40N6O8

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; water; tert-butyl alcohol at 60℃; for 3h; Inert atmosphere;91%
tert-butyl N-(3-azidopropyl)carbamate
129392-84-3

tert-butyl N-(3-azidopropyl)carbamate

erlotinib
183321-74-6

erlotinib

tert-butyl-3-(4-(3-(6,7-bis(2-methoxyethoxy)quinazolin-4-ylamino)phenyl)-1H-1,2,3-triazol-1-yl)propylcarbamate

tert-butyl-3-(4-(3-(6,7-bis(2-methoxyethoxy)quinazolin-4-ylamino)phenyl)-1H-1,2,3-triazol-1-yl)propylcarbamate

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol at 60℃; Inert atmosphere;90%
2-azidoethanesulfonyl fluoride

2-azidoethanesulfonyl fluoride

erlotinib
183321-74-6

erlotinib

2-(4-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethane-1-sulfonyl fluoride

2-(4-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethane-1-sulfonyl fluoride

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In dimethyl sulfoxide at 20℃; for 12h;90%
C54H55BF2I2N8O7

C54H55BF2I2N8O7

erlotinib
183321-74-6

erlotinib

C76H78BF2I2N11O11

C76H78BF2I2N11O11

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In ethanol; chloroform; water for 24h; Darkness;89%
benzyl azide
622-79-7

benzyl azide

erlotinib
183321-74-6

erlotinib

N-(3-(1-benzyl-1H-1,2,3-triazol-4-yl)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine

N-(3-(1-benzyl-1H-1,2,3-triazol-4-yl)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine

Conditions
ConditionsYield
With [(1-phenylisoquinoline)2Ir(acetylacetonate)] In dichloromethane at 20℃; Irradiation; regioselective reaction;87%
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In tetrahydrofuran; water; tert-butyl alcohol at 70℃;0.41 g
carbon monoxide
201230-82-2

carbon monoxide

2-(2-(1-phenylethylidene)hydrazinyl)pyridine

2-(2-(1-phenylethylidene)hydrazinyl)pyridine

erlotinib
183321-74-6

erlotinib

2-{3-[6,7-bis(2-methoxyethoxy)quinazolin-4-ylamino]phenyl}-4H-pyrido[1,2-a]pyrimidin-4-one

2-{3-[6,7-bis(2-methoxyethoxy)quinazolin-4-ylamino]phenyl}-4H-pyrido[1,2-a]pyrimidin-4-one

Conditions
ConditionsYield
With dimanganese decacarbonyl In toluene at 100℃; under 760.051 Torr; for 16h; Schlenk technique; Sealed tube;86%
N′-methyl-N′-(pyridin-2-yl)benzohydrazide

N′-methyl-N′-(pyridin-2-yl)benzohydrazide

erlotinib
183321-74-6

erlotinib

3-{3-([6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amino)phenyl}-2-(methyl(pyridin-2-yl)amino)isoquinolin-1(2H)-one

3-{3-([6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amino)phenyl}-2-(methyl(pyridin-2-yl)amino)isoquinolin-1(2H)-one

Conditions
ConditionsYield
With cobalt(II) acetate; sodium pivalate at 23℃; for 16h; Inert atmosphere; Electrolysis;85%
erlotinib
183321-74-6

erlotinib

1-azido-1-deoxy-β-D-glucopyranoside tetraacetate
13992-25-1

1-azido-1-deoxy-β-D-glucopyranoside tetraacetate

N-(3-(1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl)phenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine

N-(3-(1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl)phenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol for 24h;83%
C46H49BF2I2N8O7

C46H49BF2I2N8O7

erlotinib
183321-74-6

erlotinib

C90H95BF2I2N14O15

C90H95BF2I2N14O15

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In ethanol; chloroform; water for 24h; Darkness;82%

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