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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Olopatadine hydrochloride Manufacturer/High quality/Best price/In stock

Cas:140462-76-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications Olopatadine Hydrochloride CAS:140462-76-6

Cas:140462-76-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or off-white powder Storage:373.87 Package:100g/bottle;

High quality Olopatadine hydrochloride CAS 140462-76-6 supplied by m

Cas:140462-76-6

Min.Order:100 Gram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Olopatadine hydrochloride 140462-76-6 ISO Producer

Cas:140462-76-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Olopatadine hydrochloride

Cas:140462-76-6

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Olopatadine hydrochloride -- CHemwill

Cas:140462-76-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

140462-76-6 Olopatadine hydrochloride

Cas:140462-76-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Olopatadine hydrochloride

Cas:140462-76-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 140462-76-6 with competitive price

Cas:140462-76-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Olopatadine HCl AL 4943A

Cas:140462-76-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Olopatadine hydrochloride/ LIDE PHARMA- Factory supply / Best price

Cas:140462-76-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

Olopatadine hydrochloride For Biochemical research

Cas:140462-76-6

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Olopatadine hydrochloride Molecular Structure: Formula: C21H24ClNO3 Molecular Weight : 373.87316 Synonyms: OLOPATADINEHCL;OLOPATADINEHYDROCHLORIDE;OLOPATDI

Factory Supply Olopatadine Hydrochloride

Cas:140462-76-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Olopatadine hydrochloride 140462-76-6

Cas:140462-76-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antiallergic drugs Olopatadine hydrochloride with CAS: 140462-76-6

Cas:140462-76-6

Min.Order:1 Gram

FOB Price: $8.0 / 12.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Olopatadine hydrochloride CAS:140462-76-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

Olopatadine hydrochloride CAS:140462-76-6

Cas:140462-76-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Olopatadine hydrochloride

Cas:140462-76-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Olopatadine Hydrochloride CAS140462-76-6

Cas:140462-76-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Olopatadine hydrochloride CAS: 140462-76-6 purity:99% Stock:Fresh Application:Dual acting histamine H1-receptor antagonist and mast cell stabilizer. Antiallergic; antihistaminic.

Olopatadine hcl

Cas:140462-76-6

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

Olopatadine Hydrochloride

Cas:140462-76-6

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Olopatadine hydrochloride

Cas:140462-76-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Olopatadine hydrochloride Synonyms: OLOPATADINE HCL;OLOPATADINE HYDROCHLORIDE;(Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride;OLAPATADINE HCL;OLOPATDINEHYDROCHLORIDE;OLOPATADINE HYDRO

Olopatadine hydrochloride 99% Manufactuered in China best quality

Cas:140462-76-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Olopatadine HCl

Cas:140462-76-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Olopatadine Hydrochloride CAS 140462-76-6 with Fast Shipment

Cas:140462-76-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Olopatadine HCL

Cas:140462-76-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Olopatadine HCL

Cas:140462-76-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Various Specifications Olopatadine Hydrochloride

Cas:140462-76-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Olopatadine hclAppearance:White or Almost White crystalline powder Storage:Store in refrigerator Package:according to customers' requirements Application:Steroids injection For Body building Transportation:By air(EMS or EUB or FedEx or TNT ect...) or

Olopatadine hcl

Cas:140462-76-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Olopatadine HCl

Cas:140462-76-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Synthetic route

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid benzyl ester
60548-16-5

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid benzyl ester

anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide
27710-82-3

anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide

A

(E )-11-[ 3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride
949141-22-4

(E )-11-[ 3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride

B

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Stage #1: anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide With sodium hydride In tetrahydrofuran for 3h; Wittig Reaction; Heating / reflux;
Stage #2: (11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid benzyl ester In tetrahydrofuran at 0 - 30℃; for 3h;
Stage #3: With hydrogenchloride; water In di-isopropyl ether pH=2;
A 0.5%
B 99%
olopatadine
113806-05-6

olopatadine

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 5 - 25℃; for 2 - 15h; Product distribution / selectivity;95.6%
With hydrogenchloride In water; acetone at 0 - 25℃; for 16 - 22h; Product distribution / selectivity;88.1%
With hydrogenchloride In water; acetone at 20 - 60℃; Product distribution / selectivity;81.2%
With hydrogenchloride In water
With hydrogenchloride In tetrahydrofuran; water at 15 - 20℃; for 0.75 - 0.833333h; pH=0 - 1; Heating / reflux;
isoxepac
55453-87-7

isoxepac

N-(3-chloropropyl)-N,N-dimethylamine hydrochloride

N-(3-chloropropyl)-N,N-dimethylamine hydrochloride

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Stage #1: N-(3-chloropropyl)-N,N-dimethylamine hydrochloride With potassium bromide for 1h; Inert atmosphere;
Stage #2: With N,N,N,N,N,N-hexamethylphosphoric triamide In dimethyl sulfoxide for 2h; Reflux;
Stage #3: isoxepac In dimethyl sulfoxide at 20℃; for 1h; Reagent/catalyst; Solvent;
90.5%
(Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester
113806-01-2

(Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Stage #1: (Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester With water; sodium hydroxide In methanol for 2h; Reflux;
Stage #2: With hydrogenchloride In water pH=2;
88.4%
Stage #1: (Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester With sodium hydroxide In methanol; water at 20℃; for 3h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water for 0.0833333h;
66%
11-hydroxy-11-(3-dimethylaminopropyl)-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid

11-hydroxy-11-(3-dimethylaminopropyl)-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; acetic anhydride In toluene at 100℃; for 6h; Sealed tube;79.5%
isoxepac
55453-87-7

isoxepac

(3-dimethylaminopropyl)-triphenylphosphoniumbromide
18355-96-9

(3-dimethylaminopropyl)-triphenylphosphoniumbromide

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Stage #1: (3-dimethylaminopropyl)-triphenylphosphoniumbromide With sodium hydride In tetrahydrofuran at 20 - 22℃; for 1h;
Stage #2: isoxepac With methanol In tetrahydrofuran at 0℃; for 2h; Reflux;
60.6%
(Z)-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid ethyl ester
113806-03-4

(Z)-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid ethyl ester

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In acetone for 10h; Product distribution / selectivity; Reflux;50%
isoxepac
55453-87-7

isoxepac

anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide
27710-82-3

anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Stage #1: anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide With sodium hydride In tetrahydrofuran; mineral oil at 65℃; Inert atmosphere;
Stage #2: isoxepac In tetrahydrofuran; mineral oil at 20℃; for 15h; Wittig Reaction;
Stage #3: With hydrogenchloride In tetrahydrofuran; water; mineral oil pH=2.27; Product distribution / selectivity;
n/a
Stage #1: anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide With n-butyllithium In tetrahydrofuran at 0 - 5℃; for 1h; Inert atmosphere;
Stage #2: isoxepac In tetrahydrofuran at 0℃; Reflux;
Stage #3: With hydrogenchloride; acetic acid In tetrahydrofuran; water at 25 - 30℃; for 0.25h; Product distribution / selectivity;
3-(N,N-dimethylamino)propylmagnesium chloride
19070-16-7

3-(N,N-dimethylamino)propylmagnesium chloride

isoxepac
55453-87-7

isoxepac

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Stage #1: 3-(N,N-dimethylamino)propylmagnesium chloride; isoxepac In tetrahydrofuran at 20℃; Grignard Reaction; Inert atmosphere;
Stage #2: With ammonium chloride In tetrahydrofuran; water
Stage #3: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 17.75h; pH=~ 1; Reflux;
n/a
isoxepac
55453-87-7

isoxepac

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / dichloromethane / 5 h / Reflux
2.1: dichloromethane / 0 - 20 °C / pH 9.5 - 10
3.1: tetrahydrofuran / 1 h / 0 - 5 °C
3.2: 0 - 35 °C
3.3: 0 - 5 °C / pH 9 - 10
4.1: hydrogenchloride; water / 90 - 95 °C
4.2: 0.5 h / 10 - 15 °C / pH 6.8 - 7.2
5.1: hydrogenchloride / chlorobenzene / 5 h / 80 - 85 °C
View Scheme
Multi-step reaction with 2 steps
1: toluene; tetrahydrofuran / 2.08 h / 5 - 18 °C
2: hydrogenchloride; acetic anhydride / toluene / 6 h / 100 °C / Sealed tube
View Scheme
olopatadine
113805-63-3

olopatadine

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In chlorobenzene at 80 - 85℃; for 5h;
With hydrogenchloride at 90℃; for 5h;
C23H28N2O2

C23H28N2O2

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride; water / 90 - 95 °C
1.2: 0.5 h / 10 - 15 °C / pH 6.8 - 7.2
2.1: hydrogenchloride / chlorobenzene / 5 h / 80 - 85 °C
View Scheme
2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)acetyl chloride
87486-90-6

2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)acetyl chloride

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dichloromethane / 0 - 20 °C / pH 9.5 - 10
2.1: tetrahydrofuran / 1 h / 0 - 5 °C
2.2: 0 - 35 °C
2.3: 0 - 5 °C / pH 9 - 10
3.1: hydrogenchloride; water / 90 - 95 °C
3.2: 0.5 h / 10 - 15 °C / pH 6.8 - 7.2
4.1: hydrogenchloride / chlorobenzene / 5 h / 80 - 85 °C
View Scheme
N, N-dimethyl-2-(11-oxo-6,11-dihydrodibenz[b,e]oxepin-2-yl)acetamide

N, N-dimethyl-2-(11-oxo-6,11-dihydrodibenz[b,e]oxepin-2-yl)acetamide

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 1 h / 0 - 5 °C
1.2: 0 - 35 °C
1.3: 0 - 5 °C / pH 9 - 10
2.1: hydrogenchloride; water / 90 - 95 °C
2.2: 0.5 h / 10 - 15 °C / pH 6.8 - 7.2
3.1: hydrogenchloride / chlorobenzene / 5 h / 80 - 85 °C
View Scheme
4-hydroxyphenylacetate
156-38-7

4-hydroxyphenylacetate

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 120 - 135 °C
1.2: 5 - 10 °C
2.1: acetic acid / 2.5 h / 70 - 75 °C
3.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
3.2: 0 °C / Reflux
3.3: 0.25 h / 25 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 120 - 135 °C
1.2: 5 - 10 °C
2.1: acetic acid / 2.5 h / 70 - 75 °C
3.1: iodine; magnesium; ethylene dibromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux
3.2: 5 - 30 °C
3.3: 25 - 30 °C
View Scheme
isoxepac
55453-87-7

isoxepac

3-(Dimethylamino)propyl chloride
109-54-6

3-(Dimethylamino)propyl chloride

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Stage #1: 3-(Dimethylamino)propyl chloride With iodine; magnesium; ethylene dibromide In tetrahydrofuran for 1h; Inert atmosphere; Reflux;
Stage #2: isoxepac In tetrahydrofuran at 5 - 30℃;
Stage #3: With hydrogenchloride; acetic acid In tetrahydrofuran; water at 25 - 30℃; Product distribution / selectivity;
2-benzofuran-1(3H)-one
87-41-2

2-benzofuran-1(3H)-one

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 120 - 135 °C
1.2: 5 - 10 °C
2.1: acetic acid / 2.5 h / 70 - 75 °C
3.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
3.2: 0 °C / Reflux
3.3: 0.25 h / 25 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 120 - 135 °C
1.2: 5 - 10 °C
2.1: acetic acid / 2.5 h / 70 - 75 °C
3.1: iodine; magnesium; ethylene dibromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux
3.2: 5 - 30 °C
3.3: 25 - 30 °C
View Scheme
4-(2-carboxybenzyloxy) phenyl acetic acid
55453-89-9

4-(2-carboxybenzyloxy) phenyl acetic acid

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid / 2.5 h / 70 - 75 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
2.2: 0 °C / Reflux
2.3: 0.25 h / 25 - 30 °C
View Scheme
11-[3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride
203188-29-8

11-[3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Stage #1: 11-[3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride With hydrogenchloride In water at 25 - 95℃;
Stage #2: With acetic acid In water at 25 - 30℃; Purification / work up;
3-(N,N-dimethylamino)propylmagnesium chloride
19070-16-7

3-(N,N-dimethylamino)propylmagnesium chloride

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene; tetrahydrofuran / 2.08 h / 5 - 18 °C
2: hydrogenchloride; acetic anhydride / toluene / 6 h / 100 °C / Sealed tube
View Scheme
C15H18O5
1354633-17-2

C15H18O5

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: hydrogenchloride / methanol
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 92 °C / Inert atmosphere
4.1: pyridine / 5 - 20 °C
5.1: methanol; water / 3 h / Reflux
6.1: water; sodium hydroxide / methanol / 2 h / Reflux
6.2: pH 2
View Scheme
Multi-step reaction with 6 steps
1.1: hydrogenchloride / methanol
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: piperidine; formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / acetonitrile / 60 °C
4.1: pyridine / 5 - 20 °C
5.1: methanol; water / 3 h / Reflux
6.1: water; sodium hydroxide / methanol / 2 h / Reflux
6.2: pH 2
View Scheme
Multi-step reaction with 6 steps
1.1: hydrogenchloride; water / methanol
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 92 °C / Inert atmosphere
4.1: pyridine / 5 - 20 °C
5.1: methanol; water / 3 h / Reflux
6.1: water; sodium hydroxide / methanol / 2 h / Reflux
6.2: pH 2
View Scheme
Multi-step reaction with 6 steps
1.1: hydrogenchloride; water / methanol
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: piperidine; formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / acetonitrile / 60 °C
4.1: pyridine / 5 - 20 °C
5.1: methanol; water / 3 h / Reflux
6.1: water; sodium hydroxide / methanol / 2 h / Reflux
6.2: pH 2
View Scheme
C15H16O5
1354633-33-2

C15H16O5

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate / methanol
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 92 °C / Inert atmosphere
4.1: pyridine / 5 - 20 °C
5.1: methanol; water / 3 h / Reflux
6.1: water; sodium hydroxide / methanol / 2 h / Reflux
6.2: pH 2
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / methanol
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: piperidine; formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / acetonitrile / 60 °C
4.1: pyridine / 5 - 20 °C
5.1: methanol; water / 3 h / Reflux
6.1: water; sodium hydroxide / methanol / 2 h / Reflux
6.2: pH 2
View Scheme
Multi-step reaction with 6 steps
1.1: Alkaline conditions; Enzymatic reaction
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 92 °C / Inert atmosphere
4.1: pyridine / 5 - 20 °C
5.1: methanol; water / 3 h / Reflux
6.1: water; sodium hydroxide / methanol / 2 h / Reflux
6.2: pH 2
View Scheme
Multi-step reaction with 6 steps
1.1: Alkaline conditions; Enzymatic reaction
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: piperidine; formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / acetonitrile / 60 °C
4.1: pyridine / 5 - 20 °C
5.1: methanol; water / 3 h / Reflux
6.1: water; sodium hydroxide / methanol / 2 h / Reflux
6.2: pH 2
View Scheme
C13H14O4
1354633-20-7

C13H14O4

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide
2.1: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 92 °C / Inert atmosphere
3.1: pyridine / 5 - 20 °C
4.1: methanol; water / 3 h / Reflux
5.1: water; sodium hydroxide / methanol / 2 h / Reflux
5.2: pH 2
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide
2.1: piperidine; formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / acetonitrile / 60 °C
3.1: pyridine / 5 - 20 °C
4.1: methanol; water / 3 h / Reflux
5.1: water; sodium hydroxide / methanol / 2 h / Reflux
5.2: pH 2
View Scheme
methyl 2-{4-[(2-bromobenzyl)oxy]-3-(4-hydroxybut-1-yn-1-yl)phenyl}acetate
916243-38-4

methyl 2-{4-[(2-bromobenzyl)oxy]-3-(4-hydroxybut-1-yn-1-yl)phenyl}acetate

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: piperidine; formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / acetonitrile / 60 °C
2.1: pyridine / 5 - 20 °C
3.1: methanol; water / 3 h / Reflux
4.1: water; sodium hydroxide / methanol / 2 h / Reflux
4.2: pH 2
View Scheme
Multi-step reaction with 4 steps
1.1: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 92 °C / Inert atmosphere
2.1: pyridine / 5 - 20 °C
3.1: methanol; water / 3 h / Reflux
4.1: water; sodium hydroxide / methanol / 2 h / Reflux
4.2: pH 2
View Scheme
methyl 2-{4-[(2-bromobenzyl)oxy]phenyl}acetate
833485-11-3

methyl 2-{4-[(2-bromobenzyl)oxy]phenyl}acetate

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: iodine; silver sulfate / methanol / 2 h / 18 °C
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere
3.1: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 92 °C / Inert atmosphere
4.1: pyridine / 5 - 20 °C
5.1: methanol; water / 3 h / Reflux
6.1: water; sodium hydroxide / methanol / 2 h / Reflux
6.2: pH 2
View Scheme
Multi-step reaction with 6 steps
1.1: iodine; silver sulfate / methanol / 2 h / 18 °C
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere
3.1: piperidine; formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / acetonitrile / 60 °C
4.1: pyridine / 5 - 20 °C
5.1: methanol; water / 3 h / Reflux
6.1: water; sodium hydroxide / methanol / 2 h / Reflux
6.2: pH 2
View Scheme
methyl 2-{4-[(2-bromobenzyl)oxy]-3-iodophenyl}acetate
916243-37-3

methyl 2-{4-[(2-bromobenzyl)oxy]-3-iodophenyl}acetate

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere
2.1: piperidine; formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / acetonitrile / 60 °C
3.1: pyridine / 5 - 20 °C
4.1: methanol; water / 3 h / Reflux
5.1: water; sodium hydroxide / methanol / 2 h / Reflux
5.2: pH 2
View Scheme
Multi-step reaction with 5 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere
2.1: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 92 °C / Inert atmosphere
3.1: pyridine / 5 - 20 °C
4.1: methanol; water / 3 h / Reflux
5.1: water; sodium hydroxide / methanol / 2 h / Reflux
5.2: pH 2
View Scheme
(Z)-methyl 2-[11-(3-hydroxypropylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetate
916243-39-5

(Z)-methyl 2-[11-(3-hydroxypropylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetate

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridine / 5 - 20 °C
2.1: methanol; water / 3 h / Reflux
3.1: water; sodium hydroxide / methanol / 2 h / Reflux
3.2: pH 2
View Scheme
methyl 2-{11-[(Z)-3-(methanesulfonyloxy)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetate

methyl 2-{11-[(Z)-3-(methanesulfonyloxy)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetate

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: methanol; water / 3 h / Reflux
2.1: water; sodium hydroxide / methanol / 2 h / Reflux
2.2: pH 2
View Scheme
Methyl 4-hydroxyphenylacetate
14199-15-6

Methyl 4-hydroxyphenylacetate

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C
2.1: iodine; silver sulfate / methanol / 2 h / 18 °C
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere
4.1: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 92 °C / Inert atmosphere
5.1: pyridine / 5 - 20 °C
6.1: methanol; water / 3 h / Reflux
7.1: water; sodium hydroxide / methanol / 2 h / Reflux
7.2: pH 2
View Scheme
Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C
2.1: iodine; silver sulfate / methanol / 2 h / 18 °C
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere
4.1: piperidine; formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / acetonitrile / 60 °C
5.1: pyridine / 5 - 20 °C
6.1: methanol; water / 3 h / Reflux
7.1: water; sodium hydroxide / methanol / 2 h / Reflux
7.2: pH 2
View Scheme
Multi-step reaction with 9 steps
1.1: bromine; acetic acid
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide
4.1: hydrogenchloride / methanol
5.1: potassium carbonate / N,N-dimethyl-formamide
6.1: piperidine; formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / acetonitrile / 60 °C
7.1: pyridine / 5 - 20 °C
8.1: methanol; water / 3 h / Reflux
9.1: water; sodium hydroxide / methanol / 2 h / Reflux
9.2: pH 2
View Scheme
diethyl-(2-[4]piperidyl-ethyl)-amine
64168-10-1

diethyl-(2-[4]piperidyl-ethyl)-amine

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

1-[4-(2-diethylamino-ethyl)-piperidin-1-yl]-2-{11-[3-dimethylamino-prop-(Z)-ylidene]-6, 11-dihydro-dibenz[b,e]oxepin-2-yl}-ethanone
872040-96-5

1-[4-(2-diethylamino-ethyl)-piperidin-1-yl]-2-{11-[3-dimethylamino-prop-(Z)-ylidene]-6, 11-dihydro-dibenz[b,e]oxepin-2-yl}-ethanone

Conditions
ConditionsYield
Stage #1: diethyl-(2-[4]piperidyl-ethyl)-amine; olopatadine hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 23℃; for 16h;
Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water
99%
methanol
67-56-1

methanol

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

(Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester
113806-01-2

(Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: methanol; olopatadine hydrochloride With acetyl chloride In methanol at 23℃; for 2h;
Stage #2: With sodium hydrogencarbonate In methanol; water
94%
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