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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Olopatadine Manufacturer/High quality/Best price/In stock

Cas:113806-05-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Olopatadine supplier in China

Cas:113806-05-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Olopatadine Cas 113806-05-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white crystalline powder Storage:Cool dry place Package:25kg/

High quality Olopatadine Cas 113806-05-6 with best price and good service

Cas:113806-05-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Olopatadine 113806-05-6 GMP Manufacturer

Cas:113806-05-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Olopatadine

Cas:113806-05-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

Olopatadine

Cas:113806-05-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 113806-05-6 with competitive price

Cas:113806-05-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Dibenz[b,e]oxepin-2-aceticacid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11Z)- 113806-05-6

Cas:113806-05-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Olopatadine CAS:113806-05-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Olopatadine CAS:113806-05-6

Cas:113806-05-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Dibenz[b,e]oxepin-2-aceticacid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11Z)-

Cas:113806-05-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail

low price 99% Olopatadine CAS:113806-05-6

Cas:113806-05-6

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Dibenz[b,e]oxepin-2-aceticacid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11Z)-

Cas:113806-05-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

LY-170052 Olanzapine 113806-05-6

Cas:113806-05-6

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

OLOPATADINE

Cas:113806-05-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Olopatadine

Cas:113806-05-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(Z)-2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)aceticacid

Cas:113806-05-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Olopatadine

Cas:113806-05-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Olopatadine

Cas:113806-05-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and

TIANFUCHEM--113806-05-6--Olopatadine

Cas:113806-05-6

Min.Order:1 Metric Ton

FOB Price: $1500.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Olopatadine

Cas:113806-05-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Olopatadine CAS: 113806-05-6 MF: C21H23NO3 MW: 337.41 EINECS: Mol File: 113806-05-6.mol Olopatadine Structure Olopatadine Chemical Properties Melting point 188-189.5° CAS DataBase Reference 113806-05-6(C

Olopatadine

Cas:113806-05-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

Appearance:powder or granule ( refer to COA) Application:Librium, Valium

Factory Supply Olopatadine Hydrochloride

Cas:113806-05-6

Min.Order:0

Negotiable

Type:Other

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--113806-05-6--Olopatadine

Cas:113806-05-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Olopatadine

Cas:113806-05-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--113806-05-6--Olopatadine

Cas:113806-05-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--113806-05-6--Olopatadine

Cas:113806-05-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Olopatadine

Cas:113806-05-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Olopatadine

Cas:113806-05-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Olopatadine Cas no.113806-05-6 98%

Cas:113806-05-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFUCHEM--113806-05-6--Olopatadine

Cas:113806-05-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

(Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromide
951006-73-8

(Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromide

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
With sodium hydroxide In water at 5 - 25℃; for 20 - 21.0833h; pH=6.8 - 7.2; Product distribution / selectivity;96.09%
In water at 20 - 25℃; for 16h; pH=6.8 - 7.2; Product distribution / selectivity; Alkaline conditions;92.3%
Stage #1: (Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromide With sodium hydroxide In water; toluene at 20 - 25℃; pH=> 12;
Stage #2: With hydrogenchloride In water at 20 - 25℃; pH=6.8 - 7.2;
90%
(Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester
113806-01-2

(Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Stage #1: (Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester With methanol; sodium hydroxide; water at 20℃; for 5h;
Stage #2: With hydrogenchloride In methanol; water
Stage #3: In methanol; water
92%
With water; sodium hydroxide In methanol at 20℃; for 3h;88%
isoxepac
55453-87-7

isoxepac

N,N-dimethyl-3-bromopropylamine
53929-74-1

N,N-dimethyl-3-bromopropylamine

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-3-bromopropylamine With zinc dibromide In tetrahydrofuran at 10 - 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With naphthalene; lithium In tetrahydrofuran at 65 - 70℃; Inert atmosphere;
Stage #3: isoxepac In tetrahydrofuran at 0 - 25℃; for 16.5h; Reagent/catalyst; Temperature;
81.2%
isoxepac
55453-87-7

isoxepac

anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide
27710-82-3

anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Stage #1: anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide With sodium hydride In tetrahydrofuran; dimethyl sulfoxide; mineral oil at 20 - 45℃; Inert atmosphere; Large scale;
Stage #2: isoxepac In tetrahydrofuran; dimethyl sulfoxide; mineral oil at 20℃; Solvent; Wittig Olefination; Large scale;
55.63%
(Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid p-toluenesulfonate

(Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid p-toluenesulfonate

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
With sodium hydrogencarbonate49%
11-[(Z)-3-(dimethylamino)-propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-acetamide p-toluensulfonate
1123338-92-0

11-[(Z)-3-(dimethylamino)-propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-acetamide p-toluensulfonate

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Stage #1: 11-[(Z)-3-(dimethylamino)-propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-acetamide p-toluensulfonate With sodium hydrogencarbonate In methanol; dichloromethane; water for 0.25h;
Stage #2: With water; potassium hydroxide In methanol; dichloromethane at 70℃; for 8h;
Stage #3: With hydrogenchloride In methanol; dichloromethane; water at 20℃; pH=11;
44.3%
Reaxys ID: 12504340

Reaxys ID: 12504340

olopatadine
113806-05-6

olopatadine

(Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid butyl ester
1253179-74-6

(Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid butyl ester

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Stage #1: (Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid butyl ester With potassium hydroxide In water at 5 - 70℃; for 4h;
Stage #2: With sodium hydroxide In water; toluene at 20 - 25℃;
Stage #3: With hydrogenchloride In water; acetone; toluene at 20 - 25℃; pH=2.5 - 3.0;
3-(N,N-dimethylamino)propylmagnesium chloride
19070-16-7

3-(N,N-dimethylamino)propylmagnesium chloride

A

olopatadine
113806-05-6

olopatadine

B

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid
113806-06-7

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene; tetrahydrofuran / 2.08 h / 5 - 18 °C
2: hydrogenchloride / toluene / 7 h / 90 °C
View Scheme
11-hydroxy-11-(3-dimethylaminopropyl)-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid

11-hydroxy-11-(3-dimethylaminopropyl)-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid

A

olopatadine
113806-05-6

olopatadine

B

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid
113806-06-7

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid

Conditions
ConditionsYield
With hydrogenchloride In toluene at 90℃; for 7h;A n/a
B n/a
isoxepac
55453-87-7

isoxepac

3-dimethylaminopropyltriphenylphosphine hydrobromide

3-dimethylaminopropyltriphenylphosphine hydrobromide

A

olopatadine
113806-05-6

olopatadine

B

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid
113806-06-7

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid

Conditions
ConditionsYield
Stage #1: isoxepac; 3-dimethylaminopropyltriphenylphosphine hydrobromide With sodium hydride In tetrahydrofuran at 20 - 60℃; for 4h; Inert atmosphere; Large scale;
Stage #2: at 20℃; Inert atmosphere; Large scale; Overall yield = 62.5 %; Overall yield = 2.36 kg;
4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid
1009378-92-0

4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid

A

olopatadine
113806-05-6

olopatadine

B

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid
113806-06-7

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale
1.2: pH 1 - 2 / Large scale
2.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale
3.1: sodium hydride / tetrahydrofuran / 4 h / 20 - 60 °C / Inert atmosphere; Large scale
3.2: 20 °C / Inert atmosphere; Large scale
View Scheme
4-(2-carboxybenzyloxy) phenyl acetic acid
55453-89-9

4-(2-carboxybenzyloxy) phenyl acetic acid

A

olopatadine
113806-05-6

olopatadine

B

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid
113806-06-7

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale
2.1: sodium hydride / tetrahydrofuran / 4 h / 20 - 60 °C / Inert atmosphere; Large scale
2.2: 20 °C / Inert atmosphere; Large scale
View Scheme
o-(chloromethyl)benzoic acid methyl ester
34040-62-5

o-(chloromethyl)benzoic acid methyl ester

A

olopatadine
113806-05-6

olopatadine

B

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid
113806-06-7

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / ethanol / 24 h / Reflux
2.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale
2.2: pH 1 - 2 / Large scale
3.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale
4.1: sodium hydride / tetrahydrofuran / 4 h / 20 - 60 °C / Inert atmosphere; Large scale
4.2: 20 °C / Inert atmosphere; Large scale
View Scheme
Methyl 4-hydroxyphenylacetate
14199-15-6

Methyl 4-hydroxyphenylacetate

A

olopatadine
113806-05-6

olopatadine

B

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid
113806-06-7

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / ethanol / 24 h / Reflux
2.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale
2.2: pH 1 - 2 / Large scale
3.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale
4.1: sodium hydride / tetrahydrofuran / 4 h / 20 - 60 °C / Inert atmosphere; Large scale
4.2: 20 °C / Inert atmosphere; Large scale
View Scheme
Methyl 4-hydroxyphenylacetate
14199-15-6

Methyl 4-hydroxyphenylacetate

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
2: iodine; silver sulfate / methanol / 2.25 h / 20 °C
3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
4: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 4 h / 95 °C / Inert atmosphere
5: pyridine / 0 - 90 °C
6: methanol; water / 3 h / Reflux
7: sodium hydroxide; water / methanol / 3 h / 20 °C
View Scheme
1-Bromo-2-bromomethyl-benzene
3433-80-5

1-Bromo-2-bromomethyl-benzene

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
2: iodine; silver sulfate / methanol / 2.25 h / 20 °C
3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
4: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 4 h / 95 °C / Inert atmosphere
5: pyridine / 0 - 90 °C
6: methanol; water / 3 h / Reflux
7: sodium hydroxide; water / methanol / 3 h / 20 °C
View Scheme
methyl 2-{4-[(2-bromobenzyl)oxy]phenyl}acetate
833485-11-3

methyl 2-{4-[(2-bromobenzyl)oxy]phenyl}acetate

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: iodine; silver sulfate / methanol / 2.25 h / 20 °C
2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
3: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 4 h / 95 °C / Inert atmosphere
4: pyridine / 0 - 90 °C
5: methanol; water / 3 h / Reflux
6: sodium hydroxide; water / methanol / 3 h / 20 °C
View Scheme
methyl 2-{4-[(2-bromobenzyl)oxy]-3-iodophenyl}acetate
916243-37-3

methyl 2-{4-[(2-bromobenzyl)oxy]-3-iodophenyl}acetate

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
2: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 4 h / 95 °C / Inert atmosphere
3: pyridine / 0 - 90 °C
4: methanol; water / 3 h / Reflux
5: sodium hydroxide; water / methanol / 3 h / 20 °C
View Scheme
methyl 2-{4-[(2-bromobenzyl)oxy]-3-(4-hydroxybut-1-yn-1-yl)phenyl}acetate
916243-38-4

methyl 2-{4-[(2-bromobenzyl)oxy]-3-(4-hydroxybut-1-yn-1-yl)phenyl}acetate

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: piperidine; formic acid; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 4 h / 95 °C / Inert atmosphere
2: pyridine / 0 - 90 °C
3: methanol; water / 3 h / Reflux
4: sodium hydroxide; water / methanol / 3 h / 20 °C
View Scheme
(Z)-methyl 2-[11-(3-hydroxypropylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetate
916243-39-5

(Z)-methyl 2-[11-(3-hydroxypropylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetate

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / 0 - 90 °C
2: methanol; water / 3 h / Reflux
3: sodium hydroxide; water / methanol / 3 h / 20 °C
View Scheme
methyl 2-{11-[(Z)-3-(methanesulfonyloxy)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetate

methyl 2-{11-[(Z)-3-(methanesulfonyloxy)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetate

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol; water / 3 h / Reflux
2: sodium hydroxide; water / methanol / 3 h / 20 °C
View Scheme
isoxepac
55453-87-7

isoxepac

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1-methyl-1H-imidazole; di-tert-butyl dicarbonate; triethylamine / toluene / 8.5 h / 50 °C
2.1: tetrahydrofuran / 2.5 h / 15 - 20 °C
2.2: 0.5 h
3.1: hydrogenchloride / toluene; water / 6 h / 100 °C
View Scheme
tert-butyl 11-hydroxy-11-(3’-dimethylaminopropyl)-6,11-dihydrodibenzo[b,e]oxepin-2-acetate
1018464-53-3

tert-butyl 11-hydroxy-11-(3’-dimethylaminopropyl)-6,11-dihydrodibenzo[b,e]oxepin-2-acetate

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
With hydrogenchloride In water; toluene at 100℃; for 6h;
olopatadine
113806-05-6

olopatadine

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 5 - 25℃; for 2 - 15h; Product distribution / selectivity;95.6%
With hydrogenchloride In water; acetone at 0 - 25℃; for 16 - 22h; Product distribution / selectivity;88.1%
With hydrogenchloride In water; acetone at 20 - 60℃; Product distribution / selectivity;81.2%
With hydrogenchloride In water
With hydrogenchloride In tetrahydrofuran; water at 15 - 20℃; for 0.75 - 0.833333h; pH=0 - 1; Heating / reflux;
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

olopatadine
113806-05-6

olopatadine

(Z)-2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)-N-methoxy-N-methylacetamide
1376615-92-7

(Z)-2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)-N-methoxy-N-methylacetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 16h;37%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 16h;37%
olopatadine
113806-05-6

olopatadine

(Z)-11-<3-(dimethylamino)propylidene>-2-(2-hydroxyethyl)-6,11-dihydrodibenzoxepin
113835-76-0

(Z)-11-<3-(dimethylamino)propylidene>-2-(2-hydroxyethyl)-6,11-dihydrodibenzoxepin

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 4h; Ambient temperature;11%
olopatadine
113806-05-6

olopatadine

{3-[2-(2-Dimethylamino-ethyl)-3H-inden-1-yl]-4-hydroxy-phenyl}-acetic acid

{3-[2-(2-Dimethylamino-ethyl)-3H-inden-1-yl]-4-hydroxy-phenyl}-acetic acid

Conditions
ConditionsYield
With hydrogen bromide at 100℃; for 2h;
olopatadine
113806-05-6

olopatadine

C21H23NO2
1376615-97-2

C21H23NO2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C
2: diisobutylaluminium hydride / dichloromethane; hexanes / 1 h / -78 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C
2: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 °C
View Scheme
olopatadine
113806-05-6

olopatadine

(Z)-2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetaldehyde oxime
1376623-42-5

(Z)-2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetaldehyde oxime

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C
2: diisobutylaluminium hydride / dichloromethane; hexanes / 1 h / -78 °C
3: hydroxylamine hydrochloride; triethylamine / dichloromethane; hexanes; methanol / 5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C
2: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 °C
3: triethylamine; hydroxylamine hydrochloride / dichloromethane; methanol; hexane / 5 h / 20 °C
View Scheme
olopatadine
113806-05-6

olopatadine

(Z)-2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetaldehyde O-methyl oxime
1376623-43-6

(Z)-2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetaldehyde O-methyl oxime

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C
2: diisobutylaluminium hydride / dichloromethane; hexanes / 1 h / -78 °C
3: triethylamine / dichloromethane; hexanes; methanol / 5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C
2: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 °C
3: triethylamine / dichloromethane; methanol; hexane / 5 h / 20 °C
View Scheme

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