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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/691.html Product Name Isoxepac CAS No. 55453-87-7

Isoxepac

Cas:55453-87-7

Min.Order:1 Gram

FOB Price: $5.0

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Isoxepac Manufacturer/High quality/Best price/In stock

Cas:55453-87-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 6,11-Dihydro-11-Oxo-Dibenz[B,E]Oxepin-2-Acetic Acid supplier in China

Cas:55453-87-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Isoxepac CAS NO.55453-87-7

Cas:55453-87-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Slightly yellow or off white powder Storage:Refrigerator Pack

Olopatadine intermediate Isoxepac CAS 55453-87-7 supplied by manufacturer

Cas:55453-87-7

Min.Order:1 Kilogram

FOB Price: $300.0 / 380.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Isoxepac

Cas:55453-87-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 6,11-Dihydro-11-Oxo-Dibenz[B,E]Oxepin-2-Acetic Acid

Cas:55453-87-7

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Isoxepac

Cas:55453-87-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Isoxepac / LIDE PHARMA- Factory supply / Best price

Cas:55453-87-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM 55453-87-7 Isoxepac

Cas:55453-87-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Isoxepac

Cas:55453-87-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 55453-87-7 with best quality

Cas:55453-87-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powder 2. Fact

IsoxepacCAS55453-87-7

Cas:55453-87-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Isoxepac 55453-87-7

Cas:55453-87-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Medicine Olopatadine Intermediate Isoxepac CAS 55453-87-7 with Olapatadine raw powder

Cas:55453-87-7

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Isoxepac CAS:55453-87-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Isoxepac CAS:55453-87-7

Cas:55453-87-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

ISOXEPAC

Cas:55453-87-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Isoxepac

Cas:55453-87-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Isoxepac Synonyms: e)oxepin-2-aceticacid,6,11-dihydro-11-oxo-dibenz(;hp549;DIBENZ[B,E]OXEPIN-2-ACETIC ACID, 6,11-DIOHYDRO-11-OXO;6,11-Hydro-11-Oxo-Dibenz[B,E]Oxepin-2-Acetic Acid;Olapatadine;6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-A

Isoxepac Manufactory best quality

Cas:55453-87-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

6,11-Dihydro-11-Oxo-Dibenz[B,E]Oxepin-2-Acetic Acid

Cas:55453-87-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Isoxepac

Cas:55453-87-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Isoxepac

Cas:55453-87-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ISOXEPAC

Cas:55453-87-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Isoxepac

Cas:55453-87-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Isoxepac

Cas:55453-87-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Isoxepac

Cas:55453-87-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Olopatadine intermediate Isoxepac

Cas:55453-87-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediates Tr

Isoxepac.

Cas:55453-87-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Isoxepac Synonyms: Olopatadine Impurity 3(Olopatadine USP RC C);6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic acid, 97.0%;e)oxepin-2-aceticacid,6,11-dihydro-11-oxo-dibenz(;hp549;DIBENZ[B,E]OXEPIN-2-ACETIC ACID, 6,11-DIOHYDRO-11-O

Isoxepac

Cas:55453-87-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

Isoxepac

Cas:55453-87-7

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

4-(2-carboxybenzyloxy) phenyl acetic acid
55453-89-9

4-(2-carboxybenzyloxy) phenyl acetic acid

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Stage #1: 4-(2-carboxybenzyloxy) phenyl acetic acid With trifluoroacetic anhydride In chlorobenzene at 20℃; for 4h;
Stage #2: boron trifluoride diethyl etherate In chlorobenzene at -10 - 0℃; for 0.666667h;
96.4%
Stage #1: 4-(2-carboxybenzyloxy) phenyl acetic acid With trifluorormethanesulfonic acid; trifluoroacetic anhydride In toluene at 20 - 35℃; for 1h;
Stage #2: With water In toluene
71.3%
With acetic anhydride at 80 - 90℃; for 2h; Large scale;69.9%
4-hydroxyphenylacetate
156-38-7

4-hydroxyphenylacetate

2-(chloromethyl)benzoic acid
85888-81-9

2-(chloromethyl)benzoic acid

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Stage #1: 4-hydroxyphenylacetate With potassium hydroxide In methanol at 20℃; for 1h; Friedel-Crafts Acylation;
Stage #2: 2-(chloromethyl)benzoic acid In methanol Reflux;
Stage #3: With Eaton′s Reagent at 80℃; for 2h; Reagent/catalyst; Solvent; Concentration;
79.3%
methyl 2-bromomethylbenzoate
2417-73-4

methyl 2-bromomethylbenzoate

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: K2CO3, KI / butan-2-one / 24 h / Heating
2: KOH / aq. ethanol / Heating
3: 1.) (CF3CO)2O, 2.) 10percent aq. HCl / 1.) CH2Cl2, reflux, 4 h, 2.) acetone, reflux, 24 h
View Scheme
(4-hydroxy-phenyl)-acetic acid ethyl ester
17138-28-2

(4-hydroxy-phenyl)-acetic acid ethyl ester

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: K2CO3, KI / butan-2-one / 24 h / Heating
2: KOH / aq. ethanol / Heating
3: 1.) (CF3CO)2O, 2.) 10percent aq. HCl / 1.) CH2Cl2, reflux, 4 h, 2.) acetone, reflux, 24 h
View Scheme
2-(4-Ethoxycarbonylmethyl-phenoxymethyl)-benzoic acid methyl ester

2-(4-Ethoxycarbonylmethyl-phenoxymethyl)-benzoic acid methyl ester

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: KOH / aq. ethanol / Heating
2: 1.) (CF3CO)2O, 2.) 10percent aq. HCl / 1.) CH2Cl2, reflux, 4 h, 2.) acetone, reflux, 24 h
View Scheme
4-benzyloxy-3-carboxyphenylacetic acid
69031-39-6

4-benzyloxy-3-carboxyphenylacetic acid

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
In methylene chloride-nitromethane; 4-benzyloxy-3-chlorocarbonylphenylacetyl chloride
4-hydroxyphenylacetate
156-38-7

4-hydroxyphenylacetate

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 120 - 135 °C
1.2: 5 - 10 °C
2.1: acetic acid / 2.5 h / 70 - 75 °C
View Scheme
2-benzofuran-1(3H)-one
87-41-2

2-benzofuran-1(3H)-one

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 120 - 135 °C
1.2: 5 - 10 °C
2.1: acetic acid / 2.5 h / 70 - 75 °C
View Scheme
4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid
1009378-92-0

4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale
1.2: pH 1 - 2 / Large scale
2.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale
View Scheme
o-(chloromethyl)benzoic acid methyl ester
34040-62-5

o-(chloromethyl)benzoic acid methyl ester

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / ethanol / 24 h / Reflux
2.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale
2.2: pH 1 - 2 / Large scale
3.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale
View Scheme
Methyl 4-hydroxyphenylacetate
14199-15-6

Methyl 4-hydroxyphenylacetate

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / ethanol / 24 h / Reflux
2.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale
2.2: pH 1 - 2 / Large scale
3.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale
View Scheme
isoxepac
55453-87-7

isoxepac

11-hydroxy-2-(2-hydroxyethyl)-6,11-dihydrodibenz[b,e]oxepin
56427-65-7

11-hydroxy-2-(2-hydroxyethyl)-6,11-dihydrodibenz[b,e]oxepin

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 1h; Ambient temperature;98%
isoxepac
55453-87-7

isoxepac

benzyl alcohol
100-51-6

benzyl alcohol

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid benzyl ester
60548-16-5

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid benzyl ester

Conditions
ConditionsYield
toluene-4-sulfonic acid In toluene Reflux;98%
isoxepac
55453-87-7

isoxepac

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-butyl 11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-acetate

tert-butyl 11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-acetate

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; di-tert-butyl dicarbonate; triethylamine In toluene at 50℃; for 8.5h; Reagent/catalyst; Solvent; Temperature;97%
Stage #1: isoxepac With trifluoroacetic anhydride In toluene at 20℃; for 1h;
Stage #2: tert-butyl alcohol In toluene at 20 - 80℃; for 4h;
79.9%
isoxepac
55453-87-7

isoxepac

(Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromide
951006-73-8

(Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromide

Conditions
ConditionsYield
Stage #1: anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide With sodium hydride In tetrahydrofuran at 20 - 60℃; for 3.66667h;
Stage #2: isoxepac In tetrahydrofuran at 10 - 25℃; for 20 - 30h; Wittig Reaction;
Stage #3: With hydrogen bromide In 2-methyltetrahydrofuran; water; isopropyl alcohol pH=4.3 - 13.8; Product distribution / selectivity;
96.95%
Stage #1: (3-dimethylaminopropyl)-triphenylphosphoniumbromide With sodium hydride In tetrahydrofuran at 20 - 60℃; for 2.5h;
Stage #2: isoxepac In tetrahydrofuran at 15 - 25℃; for 40h; Wittig Reaction;
Stage #3: With hydrogen bromide In water; butan-1-ol at 0 - 25℃; pH=4.2 - 12.59; Product distribution / selectivity;
53.5%
isoxepac
55453-87-7

isoxepac

isopropyl alcohol
67-63-0

isopropyl alcohol

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid isopropyl ester
56427-76-0

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid isopropyl ester

Conditions
ConditionsYield
toluene-4-sulfonic acid Reflux;96%
methanol
67-56-1

methanol

isoxepac
55453-87-7

isoxepac

methyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetate
55689-64-0

methyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetate

Conditions
ConditionsYield
With tert.-butylnitrite at 40℃; for 48h;96%
With thionyl chloride at 0 - 20℃; for 24.5h;
With thionyl chloride at 0 - 25℃; for 24.5h;
isoxepac
55453-87-7

isoxepac

ethanol
64-17-5

ethanol

ethyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate
55453-90-2

ethyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 2h; Reflux;94%
toluene-4-sulfonic acid Reflux;93%
isoxepac
55453-87-7

isoxepac

butan-1-ol
71-36-3

butan-1-ol

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid butyl ester
60548-14-3

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid butyl ester

Conditions
ConditionsYield
With sulfuric acid at 115℃;93%
With sulfuric acid at 115℃; for 2h; Dean Stark apparatus;93%
isoxepac
55453-87-7

isoxepac

N-(3-chloropropyl)-N,N-dimethylamine hydrochloride

N-(3-chloropropyl)-N,N-dimethylamine hydrochloride

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Stage #1: N-(3-chloropropyl)-N,N-dimethylamine hydrochloride With potassium bromide for 1h; Inert atmosphere;
Stage #2: With N,N,N,N,N,N-hexamethylphosphoric triamide In dimethyl sulfoxide for 2h; Reflux;
Stage #3: isoxepac In dimethyl sulfoxide at 20℃; for 1h; Reagent/catalyst; Solvent;
90.5%
isoxepac
55453-87-7

isoxepac

Cyclopropylamine
765-30-0

Cyclopropylamine

N-cyclopropyl-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide

N-cyclopropyl-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide

Conditions
ConditionsYield
Stage #1: isoxepac With 1,1'-carbonyldiimidazole In dichloromethane for 1h;
Stage #2: Cyclopropylamine In dichloromethane at 20℃; for 2h;
90%
Stage #1: isoxepac With 1,1'-carbonyldiimidazole In dichloromethane for 1h;
Stage #2: Cyclopropylamine In dichloromethane at 20℃; for 2h;
90%
isoxepac
55453-87-7

isoxepac

1-bromo-3-propanol
627-18-9

1-bromo-3-propanol

3-bromopropyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

3-bromopropyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Inert atmosphere;89%
isoxepac
55453-87-7

isoxepac

6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-carboxaldehyde
66801-46-5

6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-carboxaldehyde

Conditions
ConditionsYield
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; 1-λ3-benzo[d][1,2]iodaoxol-3(1H)-one In 2,2,2-trifluoroethanol at 40℃; for 3h; UV-irradiation;86%
With oxygen; copper diacetate In dimethyl sulfoxide at 120℃;
isoxepac
55453-87-7

isoxepac

monomethyl monopotassium malonate
38330-80-2

monomethyl monopotassium malonate

C19H16O5

C19H16O5

Conditions
ConditionsYield
Stage #1: isoxepac With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
Stage #2: monomethyl monopotassium malonate With magnesium chloride In dichloromethane at 20℃; for 24h; Inert atmosphere;
86%
isoxepac
55453-87-7

isoxepac

isobutene
115-11-7

isobutene

tert-butyl 11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-acetate

tert-butyl 11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-acetate

Conditions
ConditionsYield
Stage #1: isoxepac With potassium carbonate; trichlorophosphate In water; chlorobenzene at 40℃;
Stage #2: isobutene In water; chlorobenzene at 40℃; for 8h; Product distribution / selectivity;
85.3%
isoxepac
55453-87-7

isoxepac

hex-5-en-3-yn-1-ol
28916-38-3

hex-5-en-3-yn-1-ol

hex-5-en-3-yn-1-yl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

hex-5-en-3-yn-1-yl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 12h; Inert atmosphere; Schlenk technique;84%
isoxepac
55453-87-7

isoxepac

2-(chloromethyl)dibenzo[b,e]oxepin-11(6H)-one
66801-38-5

2-(chloromethyl)dibenzo[b,e]oxepin-11(6H)-one

Conditions
ConditionsYield
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; dibenzenesulfonamide; 1-λ3-benzo[d][1,2]iodaoxol-3(1H)-one; tetrabutyl-ammonium chloride In dichloromethane at 40℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation;82%
isoxepac
55453-87-7

isoxepac

(4-vinyl-phenyl)-methanol
1074-61-9

(4-vinyl-phenyl)-methanol

4-vinylbenzyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

4-vinylbenzyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In dichloromethane82%
isoxepac
55453-87-7

isoxepac

N,N-dimethyl-3-bromopropylamine
53929-74-1

N,N-dimethyl-3-bromopropylamine

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-3-bromopropylamine With zinc dibromide In tetrahydrofuran at 10 - 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With naphthalene; lithium In tetrahydrofuran at 65 - 70℃; Inert atmosphere;
Stage #3: isoxepac In tetrahydrofuran at 0 - 25℃; for 16.5h; Reagent/catalyst; Temperature;
81.2%
isoxepac
55453-87-7

isoxepac

2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

2,2,2-trifluoroethyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

2,2,2-trifluoroethyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With thionyl chloride; triethylamine at 0 - 40℃; for 12.3333h; Inert atmosphere;80%
N-hydroxyphthalimide
524-38-9

N-hydroxyphthalimide

isoxepac
55453-87-7

isoxepac

1,3-dioxoisoindolin-2-yl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

1,3-dioxoisoindolin-2-yl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;80%
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 1h;71%
With dmap; diisopropyl-carbodiimide In dichloromethane
isoxepac
55453-87-7

isoxepac

2,2,2,-trichloroethoxycarbonyl azide

2,2,2,-trichloroethoxycarbonyl azide

2,2,2-trichloroethyl ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)methyl)carbamate

2,2,2-trichloroethyl ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)methyl)carbamate

Conditions
ConditionsYield
With dmap; copper diacetate In acetonitrile at 80℃; for 3h; Schlenk technique; Sealed tube;80%
3-(N,N-dimethylamino)propylmagnesium chloride
19070-16-7

3-(N,N-dimethylamino)propylmagnesium chloride

isoxepac
55453-87-7

isoxepac

11-hydroxy-11-(3-dimethylaminopropyl)-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid

11-hydroxy-11-(3-dimethylaminopropyl)-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid

Conditions
ConditionsYield
Stage #1: 3-(N,N-dimethylamino)propylmagnesium chloride; isoxepac In tetrahydrofuran; toluene at 5 - 18℃; for 2.08333h;
Stage #2: With water; acetic acid In tetrahydrofuran; toluene
79.7%
isoxepac
55453-87-7

isoxepac

4-bromo-5, 5, 5-trifluoropentan-1-ol

4-bromo-5, 5, 5-trifluoropentan-1-ol

4-bromo-5,5,5-trifluoropentyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

4-bromo-5,5,5-trifluoropentyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 12.5h; Inert atmosphere;79%
isoxepac
55453-87-7

isoxepac

methylamine hydrochloride
593-51-1

methylamine hydrochloride

N-methyl-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide

N-methyl-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane78%
isoxepac
55453-87-7

isoxepac

dibenzenesulfonamide
2618-96-4

dibenzenesulfonamide

N-[(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)methyl]-N-phenylsulfonylbenzenesulfonamide

N-[(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)methyl]-N-phenylsulfonylbenzenesulfonamide

Conditions
ConditionsYield
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; 1-λ3-benzo[d][1,2]iodaoxol-3(1H)-one In dichloromethane at 40℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation;75%
isoxepac
55453-87-7

isoxepac

1-(1-hydroxybutan-2-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

1-(1-hydroxybutan-2-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

1-(1-(2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetoxy)butan-2-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

1-(1-(2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetoxy)butan-2-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h;72%
isoxepac
55453-87-7

isoxepac

Propargylamine
2450-71-7

Propargylamine

C19H15NO3

C19H15NO3

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃; for 2h;72%
isoxepac
55453-87-7

isoxepac

6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylic acid
66801-40-9

6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylic acid

Conditions
ConditionsYield
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; [bis(acetoxy)iodo]benzene; oxygen In 2,2,2-trifluoroethanol for 24h; UV-irradiation;70%
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