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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Manufacturer/High quality/Best price/In stock

Cas:183322-18-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Chloro-6,7-(2-methoxyethoxy)-quinazoline supplier in China

Cas:183322-18-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline manufacturer/supplier

Cas:183322-18-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Chloro-6,7-(2-Methoxyethoxy)-Quinazoline

Cas:183322-18-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline 183322-18-1 ISO Producer

Cas:183322-18-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

CAS:183322-18-1/High quality/Factory supply

Cas:183322-18-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cas:183322-18-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Chloro-6,7-bis-(2-methoxyethoxy)-quinazoline

Cas:183322-18-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name: 4-Chloro-6,7-(2-methoxyethoxy)quinazoline CAS NO:183322-18-1 Grade:Erotinib hydrochloride intermediate Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vu

4-Chloro-6,7-(2-methoxyethoxy)quinazoline CAS:183322-18-1 Chinese manufacturers high-quality

Cas:183322-18-1

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

183322-18-1 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cas:183322-18-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 183322-18-1 4-Chloro-6, 7- (2-Methoxyethoxy) -Quinazoline

Cas:183322-18-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 16.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 183322-18-1 with competitive price

Cas:183322-18-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

4-Chloro-6,7-bis(2-methoxyethoxy)quinazolineCAS183322-18-1

Cas:183322-18-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

Erlotinib intermediate 99% cas no. 183322-18-1/ anti-cancer

Cas:183322-18-1

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline 183322-18-1

Cas:183322-18-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

4-Chloro-6,7-bis(2- methoxyethoxy) quinazoline

Cas:183322-18-1

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline CAS:183322-18-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline CAS:183322-18-1

Cas:183322-18-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cas:183322-18-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cas:183322-18-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Chloro-6,7-(2-Methoxyethoxy)-Quinazoline

Cas:183322-18-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:Pale yellow or off-white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common prod

4-Chloro-6,7-(2-methoxyethoxy)-quinazoline

Cas:183322-18-1

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cas:183322-18-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 183322-18-1 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cas:183322-18-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cas:183322-18-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-CHLORO-6,7-DI(2-METHOXYETHOXY)QUINAZOLINE

Cas:183322-18-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scien

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cas:183322-18-1

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Chloro-6,7-(2-methoxyethoxy)-quinazoline

Cas:183322-18-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cas:183322-18-1

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cas:183322-18-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline;cas.183322-18-1;99% in stock,competitive priceAppearance:White powder Storage:Store in an airtight container, protected from light. Package:according to customers' requirements Application:Erlotinib interm

Synthetic route

6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one
179688-29-0

6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; trichlorophosphate In toluene Heating;100%
With triethylamine; trichlorophosphate In toluene at 70 - 80℃; for 3h;90%
Stage #1: 6,7-bis-(2-methoxyethoxy)-4(3H)quinazolinone With thionyl chloride; N,N-dimethyl-formamide In dichloromethane for 6h; Reflux;
Stage #2: With sodium hydroxide In dichloromethane at 20℃; for 0.5h; pH=7 - 8;
89.5%
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane for 6h; Reflux;89.5%
6,7-bis(2-methoxyethoxy)quinazolin-4-one hydrochloride

6,7-bis(2-methoxyethoxy)quinazolin-4-one hydrochloride

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 50℃; for 3h;99.3%
6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one
179688-29-0

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
With oxalyl dichloride In chloroform; N,N-dimethyl-formamide for 1.5h; Heating;98%
With oxalyl dichloride In dichloromethane Solvent; Reagent/catalyst; Temperature; Reflux; Large scale;97%
With thionyl chloride In N,N-dimethyl-formamide at 60℃; Temperature; Concentration;95.6%
C14H18N2O5
179688-29-0

C14H18N2O5

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
With trichlorophosphate In dichloromethane; N,N-dimethyl-formamide at 20℃; for 6h; Reagent/catalyst;97.1%
With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 30℃; for 5 - 13h; Product distribution / selectivity; Heating / reflux;
Stage #1: C14H18N2O5 With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 30℃; for 5h; Heating / reflux;
Stage #2: With sodium hydroxide In dichloromethane; water; N,N-dimethyl-formamide at 25℃; for 0.25 - 0.333333h; pH=7 - 8;
Stage #1: C14H18N2O5 With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 30℃; for 5h; Heating / reflux;
Stage #2: With sodium hydroxide In dichloromethane; water; N,N-dimethyl-formamide at 25℃; for 0.25 - 0.333333h; pH=7 - 8;
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane for 5 - 13h; Product distribution / selectivity; Heating / reflux;
6,7-bis(2-methoxyethoxy)quinazolone

6,7-bis(2-methoxyethoxy)quinazolone

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
92%
92%
With oxalyl dichloride; N,N-dimethyl-formamide In methanol for 1.5h; Reflux;92%
With oxalyl dichloride In chloroform; N,N-dimethyl-formamide for 1.5h; Heating / reflux;
C13H19NO5
1006377-63-4

C13H19NO5

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetic anhydride / 110 °C
2.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
3.2: 81 percent / HCl / H2O / 90 - 130 °C
4.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
View Scheme
3,4-bis(2-methoxyethoxy) benzonitrile
80407-68-7

3,4-bis(2-methoxyethoxy) benzonitrile

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
2.2: 81 percent / HCl / H2O / 90 - 130 °C
3.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: nitric acid
2: dihydrogen peroxide
3: palladium on activated charcoal; ammonium formate
4: water / 24 h / 130 °C
5: trichlorophosphate; triethylamine
View Scheme
2-nitro-4,5-bis(2-methoxyethoxy)benzonitrile
236750-65-5

2-nitro-4,5-bis(2-methoxyethoxy)benzonitrile

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
1.2: 81 percent / HCl / H2O / 90 - 130 °C
2.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: hydrazine hydrate / water / 3 h / 20 - 30 °C
2: trifluoroacetic acid / ethyl acetate / 4 h / Reflux
3: trichlorophosphate; N,N-dimethyl-formamide / ethyl acetate / 2 h / 70 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: dihydrogen peroxide
2: palladium on activated charcoal; ammonium formate
3: water / 24 h / 130 °C
4: trichlorophosphate; triethylamine
View Scheme
3,4-bis(2-methoxyethoxy)benzaldehyde
80407-64-3

3,4-bis(2-methoxyethoxy)benzaldehyde

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydroxylamine hydrochloride; pyridine / methanol / Heating
2.1: acetic anhydride / 110 °C
3.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
4.2: 81 percent / HCl / H2O / 90 - 130 °C
5.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: hydroxylamine hydrochloride; acetic anhydride
2: nitric acid
3: dihydrogen peroxide
4: palladium on activated charcoal; ammonium formate
5: water / 24 h / 130 °C
6: trichlorophosphate; triethylamine
View Scheme
3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 98 percent / potassium carbonate / dimethylformamide / 100 °C
2.1: hydroxylamine hydrochloride; pyridine / methanol / Heating
3.1: acetic anhydride / 110 °C
4.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
5.2: 81 percent / HCl / H2O / 90 - 130 °C
6.1: 94 percent / thionyl chloride / dimethylformamide / 2 h / Heating
View Scheme
Ethyl protocatechuate
3943-89-3

Ethyl protocatechuate

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating
2: acetic acid; nitric acid / 24 h / 20 °C
3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
4: 84 percent / 12 h / 165 - 170 °C
5: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate; tetrabutylammonium iodide / acetone
2: acetic acid; nitric acid / 24 h / 20 °C
3: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
4: 84 percent / 12 h / 165 - 170 °C
5: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
View Scheme
Multi-step reaction with 5 steps
1: 68 percent / potassium carbonate; tetrabutylammonium iodide / acetone / 72 h / Heating
2: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C
3: 94 percent / hydrogen / palladium on activated carbon / methanol
4: 62 percent / formamide / 3 h / 160 °C
5: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating
View Scheme
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
183322-16-9

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid; nitric acid / 24 h / 20 °C
2: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
3: 84 percent / 12 h / 165 - 170 °C
4: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
View Scheme
Multi-step reaction with 4 steps
1: nitric acid; trifluoroacetic acid / CH2Cl2 / 20 °C
2: 94 percent / hydrogen / palladium on activated carbon / methanol
3: 62 percent / formamide / 3 h / 160 °C
4: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water
2.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
3.2: 0.5 h / 20 °C / pH 7 - 8
View Scheme
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
179688-27-8

ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / 12 h / 165 - 170 °C
2: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1: 62 percent / formamide / 3 h / 160 °C
2: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-formamide / 10 h / 130 - 140 °C
1.2: 65 - 80 °C
2.1: trichlorophosphate; triethylamine / toluene / 3 h / 70 - 80 °C
View Scheme
2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester
179688-26-7

2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen / PtO2*H2O / methanol / 20 °C / 2585.74 Torr
2: 84 percent / 12 h / 165 - 170 °C
3: phosphoryl choride; N,N-diethylaniline / 0.67 h / 70 - 90 °C
View Scheme
Multi-step reaction with 3 steps
1: 94 percent / hydrogen / palladium on activated carbon / methanol
2: 62 percent / formamide / 3 h / 160 °C
3: 98 percent / oxalyl chloride / CHCl3; dimethylformamide / 1.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux
2.2: 0.5 h / 20 °C / pH 7 - 8
View Scheme
3,4-Dihydroxybenzoic acid
99-50-3

3,4-Dihydroxybenzoic acid

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 98 percent / H2SO4 / Heating
2: 99 percent / K2CO3; TBAI / acetone / Heating
3: 85 percent / HNO3; Ac2O / 20 °C
4: 100 percent / H2 / Pd/C / ethanol
5: 90 percent / 160 °C
6: 100 percent / POCl3; diisopropylethylamine / toluene / Heating
View Scheme
Multi-step reaction with 6 steps
1.1: sulfuric acid / 10 h / 40 - 80 °C
2.1: potassium tert-butylate; potassium iodide / N,N-dimethyl-formamide / 12 h / 100 °C
3.1: sulfuric acid; nitric acid / 1 h / 20 °C / Darkness
4.1: palladium 10% on activated carbon / ethanol / 10 h / 20 °C
4.2: 20 °C
5.1: ammonium formate; triethylamine / 6 h / 160 °C
6.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C
View Scheme
3,4-dihydroxybenzoic acid methyl ester
2150-43-8

3,4-dihydroxybenzoic acid methyl ester

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 99 percent / K2CO3; TBAI / acetone / Heating
2: 85 percent / HNO3; Ac2O / 20 °C
3: 100 percent / H2 / Pd/C / ethanol
4: 90 percent / 160 °C
5: 100 percent / POCl3; diisopropylethylamine / toluene / Heating
View Scheme
methyl 3,4-bis{[2-(methyloxy)ethyl]oxy}benzoate
179688-14-3

methyl 3,4-bis{[2-(methyloxy)ethyl]oxy}benzoate

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 85 percent / HNO3; Ac2O / 20 °C
2: 100 percent / H2 / Pd/C / ethanol
3: 90 percent / 160 °C
4: 100 percent / POCl3; diisopropylethylamine / toluene / Heating
View Scheme
Multi-step reaction with 4 steps
1: nitric acid; acetic anhydride; acetic acid / acetic acid / 0 - 5 °C
2: hydrogen / ethanol
3: ethanol / Reflux
4: thionyl chloride / N,N-dimethyl-formamide / Reflux
View Scheme
2-amino-4,5-bis-(2-methoxyethoxy)-benzoic acid methyl ester
476168-17-9

2-amino-4,5-bis-(2-methoxyethoxy)-benzoic acid methyl ester

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / 160 °C
2: 100 percent / POCl3; diisopropylethylamine / toluene / Heating
View Scheme
Multi-step reaction with 2 steps
1: ethanol / Reflux
2: thionyl chloride / N,N-dimethyl-formamide / Reflux
View Scheme
Multi-step reaction with 2 steps
1: formamide / 160 - 165 °C
2: thionyl chloride / N,N-dimethyl-formamide / 0.67 h / 85 °C
View Scheme
methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate
501684-22-6

methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / H2 / Pd/C / ethanol
2: 90 percent / 160 °C
3: 100 percent / POCl3; diisopropylethylamine / toluene / Heating
View Scheme
Multi-step reaction with 3 steps
1: hydrogen / ethanol
2: ethanol / Reflux
3: thionyl chloride / N,N-dimethyl-formamide / Reflux
View Scheme
2-methoxy-ethanol
109-86-4

2-methoxy-ethanol

4-chloro-6,7-dihydroxyquinazoline
1145671-36-8

4-chloro-6,7-dihydroxyquinazoline

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
With PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate In dichloromethane at 0 - 20℃; Mitsunobu reaction;
ethyl 2-amino-4,5-bis-(2-methoxyethoxy)benzoate hydrochloride

ethyl 2-amino-4,5-bis-(2-methoxyethoxy)benzoate hydrochloride

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 25 - 145 °C
2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere
2: oxalyl dichloride; N,N-dimethyl-formamide / methanol / 1.5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: ammonium formate / 3 h / 160 - 165 °C / Inert atmosphere
2: pyridine; trichlorophosphate / 2.5 h / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: formic acid / 160 °C / Large scale
2: oxalyl dichloride / dichloromethane / Reflux; Large scale
View Scheme
Multi-step reaction with 2 steps
1: ammonium formate; triethylamine / 6 h / 160 °C
2: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 3 h / 50 °C
View Scheme
C22H29NO8S

C22H29NO8S

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium hydroxide / methanol / 2 h / 20 °C
2: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
3: sodium hydroxide / ethanol / 20 °C
4: ethanol / 1 h / Reflux
5: hydrogenchloride / water / 2 h / 100 - 105 °C
6: trichlorophosphate / toluene / 4 h / Reflux
View Scheme
3,4-bis(2-methoxyethoxy)-benzoic acid
819813-71-3

3,4-bis(2-methoxyethoxy)-benzoic acid

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: triethylamine; dmap / dichloromethane / 24 h / 20 °C
4: sodium hydroxide / methanol / 2 h / 20 °C
5: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
6: sodium hydroxide / ethanol / 20 °C
7: ethanol / 1 h / Reflux
8: hydrogenchloride / water / 2 h / 100 - 105 °C
9: trichlorophosphate / toluene / 4 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: sulfuric acid / Cooling with ice; Reflux
2: nitric acid; acetic acid / 24.5 h / 0 - 20 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 12 h
4: 12 h / 165 - 170 °C / Inert atmosphere
5: trichlorophosphate / 6 h / Reflux
View Scheme
C13H17ClO5

C13H17ClO5

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: triethylamine; dmap / dichloromethane / 24 h / 20 °C
3: sodium hydroxide / methanol / 2 h / 20 °C
4: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
5: sodium hydroxide / ethanol / 20 °C
6: ethanol / 1 h / Reflux
7: hydrogenchloride / water / 2 h / 100 - 105 °C
8: trichlorophosphate / toluene / 4 h / Reflux
View Scheme
C15H23NO6

C15H23NO6

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: triethylamine; dmap / dichloromethane / 24 h / 20 °C
2: sodium hydroxide / methanol / 2 h / 20 °C
3: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
4: sodium hydroxide / ethanol / 20 °C
5: ethanol / 1 h / Reflux
6: hydrogenchloride / water / 2 h / 100 - 105 °C
7: trichlorophosphate / toluene / 4 h / Reflux
View Scheme
2-(3,4-bis(2-methoxyethoxy)phenyl)-4,5-dihydro-oxazole

2-(3,4-bis(2-methoxyethoxy)phenyl)-4,5-dihydro-oxazole

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate; [bis(acetoxy)iodo]benzene / dichloromethane / 16 h / 40 °C / Inert atmosphere
2: sodium hydroxide / ethanol / 20 °C
3: ethanol / 1 h / Reflux
4: hydrogenchloride / water / 2 h / 100 - 105 °C
5: trichlorophosphate / toluene / 4 h / Reflux
View Scheme
C17H21F3N2O6

C17H21F3N2O6

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / ethanol / 20 °C
2: ethanol / 1 h / Reflux
3: hydrogenchloride / water / 2 h / 100 - 105 °C
4: trichlorophosphate / toluene / 4 h / Reflux
View Scheme
2-(4,5-dihydro-1,3-oxazol-2-yl)-4,5-bis(2-methoxyethoxy)aniline

2-(4,5-dihydro-1,3-oxazol-2-yl)-4,5-bis(2-methoxyethoxy)aniline

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol / 1 h / Reflux
2: hydrogenchloride / water / 2 h / 100 - 105 °C
3: trichlorophosphate / toluene / 4 h / Reflux
View Scheme
2-((6,7-bis(2-methoxyethoxy))-4-quinazolinylamino)-ethanol

2-((6,7-bis(2-methoxyethoxy))-4-quinazolinylamino)-ethanol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water / 2 h / 100 - 105 °C
2: trichlorophosphate / toluene / 4 h / Reflux
View Scheme
4-Iodophenol
540-38-5

4-Iodophenol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

4-(4-iodo-phenoxy)-6,7-bis-(2-methoxy-ethoxy)-quinazoline
882511-67-3

4-(4-iodo-phenoxy)-6,7-bis-(2-methoxy-ethoxy)-quinazoline

Conditions
ConditionsYield
With potassium carbonate In isopropyl alcohol Heating;100%
3-Iodoaniline
626-01-7

3-Iodoaniline

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-iodo-phenyl)-amine
882511-64-0

[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-iodo-phenyl)-amine

Conditions
ConditionsYield
With isopropyl alcohol Heating;100%
p-aminoiodobenzene
540-37-4

p-aminoiodobenzene

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-iodo-phenyl)-amine
882511-65-1

[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-iodo-phenyl)-amine

Conditions
ConditionsYield
With isopropyl alcohol Heating;100%
2-methyl-4-(3-aminophenyl)-3-butyn-2-ol
69088-96-6

2-methyl-4-(3-aminophenyl)-3-butyn-2-ol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride
299912-59-7

3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride

Conditions
ConditionsYield
In acetonitrile at 25℃; for 5h; Inert atmosphere; Reflux;100%
In acetonitrile for 5h; Inert atmosphere; Reflux;100%
1-tert-butyloxycarbonyl-4-(4-amino-2-methylphenyloxy)piperidine
138227-69-7

1-tert-butyloxycarbonyl-4-(4-amino-2-methylphenyloxy)piperidine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-methyl-4-(piperidin-4-yloxy)-phenyl]-amine hydrochloride

[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-methyl-4-(piperidin-4-yloxy)-phenyl]-amine hydrochloride

Conditions
ConditionsYield
Stage #1: 1-tert-butyloxycarbonyl-4-(4-amino-2-methylphenyloxy)piperidine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline In 1,2-dichloro-ethane; tert-butyl alcohol at 90℃; for 1h;
Stage #2: With hydrogenchloride In 1,2-dichloro-ethane; tert-butyl alcohol at 20℃; for 0.166667h;
99%
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

erlotinib hydrochloride
183319-69-9

erlotinib hydrochloride

Conditions
ConditionsYield
In isopropyl alcohol for 18h; Heating;98%
In iso-propanol (IPA) for 0.5h; Product distribution / selectivity; Heating / reflux;97%
Stage #1: 3-acetylenephenylamine; 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline In N,N-dimethyl-formamide; acetonitrile at 90℃; for 7h; Darkness;
Stage #2: With hydrogenchloride In water at 15 - 30℃; Temperature; Solvent;
97.6%
1,2-dimethylindole
875-79-6

1,2-dimethylindole

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

4-(1,2-dimethyl-1H-indol-3-yl)-6,7-bis(2-methoxyethoxy)quinazoline

4-(1,2-dimethyl-1H-indol-3-yl)-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
With 1,1,1,3',3',3'-hexafluoro-propanol; bis(trifluoromethanesulfonyl)amide at 100℃; for 6h; Sealed tube;98%
1-ethyl-2-phenyl-1H-indole
13228-39-2

1-ethyl-2-phenyl-1H-indole

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

4-(1-ethyl-2-phenyl-1H-indol-3-yl)-6,7-bis(2-methoxyethoxy)quinazoline

4-(1-ethyl-2-phenyl-1H-indol-3-yl)-6,7-bis(2-methoxyethoxy)quinazoline

Conditions
ConditionsYield
With 1,1,1,3',3',3'-hexafluoro-propanol; bis(trifluoromethanesulfonyl)amide at 100℃; for 6h; Sealed tube;98%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

6,7-bis(2-methoxyethoxy)-N-(4-methoxyphenyl)quinazolin-4-amine
299912-64-4

6,7-bis(2-methoxyethoxy)-N-(4-methoxyphenyl)quinazolin-4-amine

Conditions
ConditionsYield
In isopropyl alcohol at 80℃; for 0.666667h; Temperature;97.21%
In water; isopropyl alcohol
3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

erlotinib
183321-74-6

erlotinib

Conditions
ConditionsYield
In isopropyl alcohol Concentration; Reflux;96.6%
In isopropyl alcohol Temperature; Reflux;96.6%
In isopropyl alcohol at 20℃; Concentration; Temperature; Reflux;96.6%
2-(3-aminophenyl)ethan-1-ol
52273-77-5

2-(3-aminophenyl)ethan-1-ol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

2-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)ethan-1-ol

2-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)ethan-1-ol

Conditions
ConditionsYield
With pyridine In isopropyl alcohol for 4h; Reflux; Inert atmosphere;96%
ethyl (E)-3-(3-aminophenyl)acrylate
125872-97-1

ethyl (E)-3-(3-aminophenyl)acrylate

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

ethyl (E)-3-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)acrylate
1453173-53-9

ethyl (E)-3-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)acrylate

Conditions
ConditionsYield
In isopropyl alcohol for 5h; Reflux;93.6%
3-biphenyl amine
2243-47-2

3-biphenyl amine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

[6,7-di(2-methoxyethoxy)quinazolin-4-yl]-(biphenyl-3'-yl)amine hydrochloride
1456819-76-3

[6,7-di(2-methoxyethoxy)quinazolin-4-yl]-(biphenyl-3'-yl)amine hydrochloride

Conditions
ConditionsYield
In isopropyl alcohol at 80℃; for 0.25h; Microwave irradiation;93%
m-ethylaniline
587-02-0

m-ethylaniline

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
299912-61-1

N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine

Conditions
ConditionsYield
In water; ethyl acetate; isopropyl alcohol90%
3-chloro-4-(3-(2-nitro-1H-imidazol-1-yl)propoxy)aniline

3-chloro-4-(3-(2-nitro-1H-imidazol-1-yl)propoxy)aniline

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

N-(3-chloro-4-(3-(2-nitro-1H-imidazol-1-yl)propoxy)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine

N-(3-chloro-4-(3-(2-nitro-1H-imidazol-1-yl)propoxy)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine

Conditions
ConditionsYield
In isopropyl alcohol for 2h; Reflux;89%
(2-amino-6-bromophenyl)methanol
861106-92-5

(2-amino-6-bromophenyl)methanol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

C21H24BrN3O5
1347720-73-3

C21H24BrN3O5

Conditions
ConditionsYield
With pyridine In acetonitrile for 4h; Reflux;88.89%
With pyridine In acetonitrile for 4h; Reflux;88.89%
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

6,7-bis(2-methoxyethoxy)-N-[3-[(trimethylsilyl)ethynyl]phenyl]-4-quinazolinamine, monohydrochloride
299912-58-6

6,7-bis(2-methoxyethoxy)-N-[3-[(trimethylsilyl)ethynyl]phenyl]-4-quinazolinamine, monohydrochloride

Conditions
ConditionsYield
With aniline In isopropyl alcohol88%
(2-amino-6-chlorophenyl)methanol
39885-08-0

(2-amino-6-chlorophenyl)methanol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

C21H24ClN3O5
1347720-70-0

C21H24ClN3O5

Conditions
ConditionsYield
In isopropyl alcohol for 4h; Reflux;87.63%
In isopropyl alcohol for 4h; Reflux;87.63%
methyl 3-amino-1H-pyrrole-2-carboxylate
1326566-41-9

methyl 3-amino-1H-pyrrole-2-carboxylate

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

methyl 3-(6,7-bis(2-methoxyethoxy)quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate
1326566-33-9

methyl 3-(6,7-bis(2-methoxyethoxy)quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate

Conditions
ConditionsYield
In isopropyl alcohol for 4h; Reflux;87%
1-(2-amino-4-chlorophenyl)pentyl-1-alcohol
1347720-50-6

1-(2-amino-4-chlorophenyl)pentyl-1-alcohol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

C25H32ClN3O5
1347721-31-6

C25H32ClN3O5

Conditions
ConditionsYield
With sulfuric acid In isopropyl alcohol at 20℃;86.67%
2-amino-6-nitrobenzyl alcohol
98451-51-5

2-amino-6-nitrobenzyl alcohol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

C21H24N4O7
1347720-82-4

C21H24N4O7

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; water at 20℃; for 7h;86.46%
With hydrogenchloride In 1,4-dioxane; water at 20℃; for 7h;86.46%
2-amino-6-cyanobenzyl alcohol
1347720-24-4

2-amino-6-cyanobenzyl alcohol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

C22H24N4O5
1347720-85-7

C22H24N4O5

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 20℃;86.3%
(2-amino-6-methoxyphenyl)methanol
177531-95-2

(2-amino-6-methoxyphenyl)methanol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

C22H27N3O6
1347720-91-5

C22H27N3O6

Conditions
ConditionsYield
In acetonitrile at 20℃;86.24%
1-methylindole
603-76-9

1-methylindole

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
183322-18-1

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

6,7-bis(2-methoxyethoxy)-4-(1-methyl-1H-indol-3-yl)quinazoline

6,7-bis(2-methoxyethoxy)-4-(1-methyl-1H-indol-3-yl)quinazoline

Conditions
ConditionsYield
With 1,1,1,3',3',3'-hexafluoro-propanol; bis(trifluoromethanesulfonyl)amide at 100℃; for 6h; Sealed tube;86%
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