DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:196597-26-9
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:196597-26-9
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:196597-26-9
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquirySleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric
Cas:196597-26-9
Min.Order:10000 Gram
FOB Price: $1300.0
Type:Manufacturers
inquiryRamelteon CAS No.:196597-26-9 Name: Ramelteon Synonyms: (S)-N-[2-(1,6,7,8-Tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide Molecular Structure
Cas:196597-26-9
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:196597-26-9
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Ramelteon The alias:CS-1962;TAK-375;ROZEREM;TAK375;TAK375;;N-[2-[(8S)-1,6,Chemicalbook7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide; CAS NO:196597-26-9 Molecular formula:C16H21NO2 Molecular weight:259.3434 Product Quality
Cas:196597-26-9
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryWe are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:196597-26-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:196597-26-9
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:196597-26-9
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:196597-26-9
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powder 2. Fact
Cas:196597-26-9
Min.Order:1 Kilogram
FOB Price: $9.0 / 10.0
Type:Trading Company
inquiryName: Ramelteon Synonyms: N-{2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]fur-8-yl]ethyl}propanamid CAS:196597-26-9 MF: C16H21NO2 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Applicatio
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:196597-26-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:196597-26-9
Min.Order:1 Gram
FOB Price: $42.0 / 48.0
Type:Trading Company
inquiryQingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical
Cas:196597-26-9
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o
Cas:196597-26-9
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:196597-26-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:196597-26-9
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryRamelteon CAS: 196597-26-9 Specification Item Standard Structural data confirmation 1. H-NMR: The data of structure are identical with reference standard 2. HPLC-MS: Ensure the mo
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Cas:196597-26-9
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:196597-26-9
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:196597-26-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:196597-26-9
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquirypropionyl chloride
ramelteon
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 1h; | 97.4% |
Stage #1: (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)-ethylamine hydrochloride With sodium hydroxide In tetrahydrofuran; water at 15℃; Stage #2: propionyl chloride In tetrahydrofuran; water at 20℃; | 96% |
With sodium hydroxide In tetrahydrofuran; water | 92% |
propionyl chloride
ramelteon
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 90% |
With sodium hydroxide In tetrahydrofuran at 20℃; for 2h; | |
With triethylamine In dichloromethane at 20℃; for 2h; | n/a |
methanesulfonyl chloride
(S)-N-[2-(6-hydroxy-7-(2-hydroxyethyl)-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide
ramelteon
Conditions | Yield |
---|---|
Stage #1: methanesulfonyl chloride; (S)-N-[2-(6-hydroxy-7-(2-hydroxyethyl)-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide With pyridine at -10 - -5℃; for 0.833333h; Stage #2: With triethylamine In ethyl acetate Heating; Further stages.; | 86% |
With hydrogenchloride; sodium hydrogencarbonate; triethylamine In pyridine; water; ethyl acetate |
(S)-N-[2-(6-hydroxy-7-(2-hydroxyethyl)-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide
ramelteon
Conditions | Yield |
---|---|
Stage #1: (S)-N-[2-(6-hydroxy-7-(2-hydroxyethyl)-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide With methanesulfonyl chloride In pyridine at -10 - -5℃; for 0.833333h; Stage #2: With sodium hydrogencarbonate In water; ethyl acetate at -10 - 20℃; for 0.5h; Stage #3: With triethylamine for 0.666667h; Heating / reflux; | 86% |
propionyl chloride
ramelteon
Conditions | Yield |
---|---|
Stage #1: (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine dibenzoyl-L-tartaric acid With water; sodium hydroxide In tetrahydrofuran at -10℃; Stage #2: propionyl chloride In tetrahydrofuran at -10 - 20℃; for 2h; | 85% |
Stage #1: (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine dibenzoyl-L-tartaric acid With sodium hydroxide In dichloromethane; water Stage #2: propionyl chloride In tetrahydrofuran; water at 20℃; Cooling with ice; |
(S)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetonitrile
propionic acid anhydride
ramelteon
Conditions | Yield |
---|---|
Stage #1: (S)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetonitrile; propionic acid anhydride With hydrogen; Raney-Ni In tetrahydrofuran at 80℃; under 3000.3 Torr; Stage #2: With sodium hydroxide In tetrahydrofuran; toluene for 0.5h; | 81% |
With hydrogen; platinum on carbon In tetrahydrofuran at 65℃; under 7500.75 - 9000.9 Torr; Product distribution / selectivity; |
propionyl chloride
ramelteon
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane; water at -5 - 10℃; | 80% |
propionic acid anhydride
ramelteon
Conditions | Yield |
---|---|
With sodium hydroxide In water at 10 - 60℃; pH=6.0 - 6.5; | 73% |
Stage #1: (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)-ethylamine hydrochloride With sodium hydroxide In tetrahydrofuran; water Stage #2: propionic acid anhydride In tetrahydrofuran; water at 20 - 25℃; |
propionic acid anhydride
ramelteon
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 1h; optical yield given as %ee; | 62% |
Propionamid
ramelteon
Conditions | Yield |
---|---|
With triethylsilane; trifluoroacetic acid In toluene at 80℃; for 24h; | 54% |
2-(1,6-dihydro-2H-indeno[5,4-b]furan-8-yl)acetamide
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: H2; Ru(OAc)2[(R)-binap] / ethanol / 6 h / 50 °C / 75006 Torr 2.1: BF3*Et2O; NaBH4 / tetrahydrofuran / 24 h / 20 °C 2.2: 63 percent / aq. HCl / ethyl acetate View Scheme |
(S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetamide
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: BF3*Et2O; NaBH4 / tetrahydrofuran / 24 h / 20 °C 1.2: 63 percent / aq. HCl / ethyl acetate View Scheme | |
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C 2: triethylamine / dichloromethane / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 16 - 26 h / -10 - 20 °C 2.1: sodium hydroxide; water / toluene / 0.5 h / 20 °C 2.2: 0.67 h View Scheme |
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C 1.2: 83 percent / tetrahydrofuran / 2 h / 20 °C 2.1: 32 percent / aq. H2O2; KOH / dimethylsulfoxide; H2O / 3 h / 20 °C 3.1: H2; Ru(OAc)2[(R)-binap] / ethanol / 6 h / 50 °C / 75006 Torr 4.1: BF3*Et2O; NaBH4 / tetrahydrofuran / 24 h / 20 °C 4.2: 63 percent / aq. HCl / ethyl acetate View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran / 1 h / 25 °C / Large scale 1.2: 3.5 h / Large scale 2.1: sodium tetrahydroborate / ethanol / 2 h / Large scale 3.1: hydrogenchloride / water; methanol / 1 h / 45 °C / Large scale 4.1: palladium on activated charcoal; hydrogen / methanol / 1 h / 60 °C / 750.08 Torr / Large scale 5.1: methanol / 1 h / 55 - 60 °C / Large scale 6.1: sodium hydroxide / tetrahydrofuran; water / 0.08 h / Large scale 6.2: 2 h / 10 °C / Large scale View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium methylate / 5 - 25 °C 2.1: ammonia / nickel / ethanol / 3 - 4 h / 50 °C / 14711.4 Torr 3.1: isopropyl alcohol / 24 h / 26 °C 4.1: dichloromethane 4.2: 26 °C 5.1: toluene / -5 - 0 °C 5.2: 0.25 - 0.33 h View Scheme | |
Multi-step reaction with 9 steps 1.1: sodium hydride / toluene / 2 h / 0 - 5 °C 1.2: 15 - 18 h / 90 - 100 °C 2.1: hydrogen / palladium 10% on activated carbon / methanol; water / 2 - 3 h / 20 °C 3.1: methanol; sodium hydroxide; water / 2 - 3 h / 20 °C 4.1: water; isopropyl alcohol / 0.5 - 0.75 h / 60 - 65 °C / Resolution of racemate 5.1: hydrogenchloride; water / pH 2.0 6.1: triethylamine / dichloromethane / 1 - 2 h / -10 - 0 °C 7.1: ammonia / dichloromethane / 0.5 - 0.75 h / -10 - 0 °C 8.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 16 - 26 h / -10 - 20 °C 9.1: sodium hydroxide; water / toluene / 0.5 h / 20 °C 9.2: 0.67 h View Scheme | |
Multi-step reaction with 9 steps 1.1: sodium hydride / toluene / 2 h / 0 - 5 °C 1.2: 15 - 18 h / 90 - 100 °C 2.1: hydrogen / palladium 10% on activated carbon / methanol; water / 2 - 3 h / 20 °C 3.1: methanol; sodium hydroxide; water / 2 - 3 h / 20 °C 4.1: water; isopropyl alcohol / 0.5 - 0.75 h / 60 - 65 °C / Resolution of racemate 5.1: hydrogenchloride; water / pH 2.0 6.1: thionyl chloride / 3 h / 20 °C 7.1: ammonia / dichloromethane; water 8.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 16 - 26 h / -10 - 20 °C 9.1: sodium hydroxide; water / toluene / 0.5 h / 20 °C 9.2: 0.67 h View Scheme |
(E)-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)acetonitrile
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 32 percent / aq. H2O2; KOH / dimethylsulfoxide; H2O / 3 h / 20 °C 2.1: H2; Ru(OAc)2[(R)-binap] / ethanol / 6 h / 50 °C / 75006 Torr 3.1: BF3*Et2O; NaBH4 / tetrahydrofuran / 24 h / 20 °C 3.2: 63 percent / aq. HCl / ethyl acetate View Scheme |
6-methoxy-2,3-dihydro-1H-inden-1-one
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: NaH / tetrahydrofuran / 20 °C 1.2: tetrahydrofuran / 20 °C 2.1: H2; ethanolic NH3 / Raney-Co 3.1: Et3N / tetrahydrofuran / 0 °C 4.1: 86 percent / NaOAc; Br2 / 0 °C 5.1: 94 percent / BBr3 / CH2Cl2 / 0.67 h / -20 - 20 °C 6.1: NaH / dimethylformamide / 0 °C 6.2: 96 percent / dimethylformamide / 0 °C 7.1: 80 percent / various solvent(s) / 200 - 205 °C 8.1: O3 / methanol / -78 °C 8.2: 99 percent / NaBH4 / methanol / 1 h / -70 - 20 °C 9.1: 91 percent / Et3N; H2 / 10percent Pd/C/H2O / ethanol / 20 °C 10.1: pyridine / 0.83 h / -10 - -5 °C 10.2: 86 percent / Et3N / ethyl acetate / Heating View Scheme |
(E)-(2,3-dihydro-6-methoxy-1H-inden-1-ylidene)acetonitrile
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: H2; ethanolic NH3 / Raney-Co 2.1: Et3N / tetrahydrofuran / 0 °C 3.1: 86 percent / NaOAc; Br2 / 0 °C 4.1: 94 percent / BBr3 / CH2Cl2 / 0.67 h / -20 - 20 °C 5.1: NaH / dimethylformamide / 0 °C 5.2: 96 percent / dimethylformamide / 0 °C 6.1: 80 percent / various solvent(s) / 200 - 205 °C 7.1: O3 / methanol / -78 °C 7.2: 99 percent / NaBH4 / methanol / 1 h / -70 - 20 °C 8.1: 91 percent / Et3N; H2 / 10percent Pd/C/H2O / ethanol / 20 °C 9.1: pyridine / 0.83 h / -10 - -5 °C 9.2: 86 percent / Et3N / ethyl acetate / Heating View Scheme |
(E)-2-(2,3-dihydro-6-methoxy-1H-inden-1-ylidene)ethanamine
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: Et3N / tetrahydrofuran / 0 °C 2.1: 86 percent / NaOAc; Br2 / 0 °C 3.1: 94 percent / BBr3 / CH2Cl2 / 0.67 h / -20 - 20 °C 4.1: NaH / dimethylformamide / 0 °C 4.2: 96 percent / dimethylformamide / 0 °C 5.1: 80 percent / various solvent(s) / 200 - 205 °C 6.1: O3 / methanol / -78 °C 6.2: 99 percent / NaBH4 / methanol / 1 h / -70 - 20 °C 7.1: 91 percent / Et3N; H2 / 10percent Pd/C/H2O / ethanol / 20 °C 8.1: pyridine / 0.83 h / -10 - -5 °C 8.2: 86 percent / Et3N / ethyl acetate / Heating View Scheme |
(Z)-N-[2-(6-methoxyindan-1-ylidene)ethyl]propionamide
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 86 percent / NaOAc; Br2 / 0 °C 2.1: 94 percent / BBr3 / CH2Cl2 / 0.67 h / -20 - 20 °C 3.1: NaH / dimethylformamide / 0 °C 3.2: 96 percent / dimethylformamide / 0 °C 4.1: 80 percent / various solvent(s) / 200 - 205 °C 5.1: O3 / methanol / -78 °C 5.2: 99 percent / NaBH4 / methanol / 1 h / -70 - 20 °C 6.1: 91 percent / Et3N; H2 / 10percent Pd/C/H2O / ethanol / 20 °C 7.1: pyridine / 0.83 h / -10 - -5 °C 7.2: 86 percent / Et3N / ethyl acetate / Heating View Scheme |
(S)-N-[2-(5-bromo-6-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: NaH / dimethylformamide / 0 °C 1.2: 96 percent / dimethylformamide / 0 °C 2.1: 80 percent / various solvent(s) / 200 - 205 °C 3.1: O3 / methanol / -78 °C 3.2: 99 percent / NaBH4 / methanol / 1 h / -70 - 20 °C 4.1: 91 percent / Et3N; H2 / 10percent Pd/C/H2O / ethanol / 20 °C 5.1: pyridine / 0.83 h / -10 - -5 °C 5.2: 86 percent / Et3N / ethyl acetate / Heating View Scheme |
(S)-N-[2-(5-bromo-6-methoxy-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 94 percent / BBr3 / CH2Cl2 / 0.67 h / -20 - 20 °C 2.1: NaH / dimethylformamide / 0 °C 2.2: 96 percent / dimethylformamide / 0 °C 3.1: 80 percent / various solvent(s) / 200 - 205 °C 4.1: O3 / methanol / -78 °C 4.2: 99 percent / NaBH4 / methanol / 1 h / -70 - 20 °C 5.1: 91 percent / Et3N; H2 / 10percent Pd/C/H2O / ethanol / 20 °C 6.1: pyridine / 0.83 h / -10 - -5 °C 6.2: 86 percent / Et3N / ethyl acetate / Heating View Scheme |
(S)-N-[2-(6-allyloxy-5-bromo-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 80 percent / various solvent(s) / 200 - 205 °C 2.1: O3 / methanol / -78 °C 2.2: 99 percent / NaBH4 / methanol / 1 h / -70 - 20 °C 3.1: 91 percent / Et3N; H2 / 10percent Pd/C/H2O / ethanol / 20 °C 4.1: pyridine / 0.83 h / -10 - -5 °C 4.2: 86 percent / Et3N / ethyl acetate / Heating View Scheme |
(S)-N-[2-(7-allyl-5-bromo-6-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: O3 / methanol / -78 °C 1.2: 99 percent / NaBH4 / methanol / 1 h / -70 - 20 °C 2.1: 91 percent / Et3N; H2 / 10percent Pd/C/H2O / ethanol / 20 °C 3.1: pyridine / 0.83 h / -10 - -5 °C 3.2: 86 percent / Et3N / ethyl acetate / Heating View Scheme |
(S)-N-[2-(5-bromo-6-hydroxy-7-(2-hydroxyethyl)-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 91 percent / Et3N; H2 / 10percent Pd/C/H2O / ethanol / 20 °C 2.1: pyridine / 0.83 h / -10 - -5 °C 2.2: 86 percent / Et3N / ethyl acetate / Heating View Scheme |
(S)-2-(1,6,7,8,-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine
ethylmagnesium bromide
ramelteon
Conditions | Yield |
---|---|
Stage #1: (S)-2-(1,6,7,8,-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine; ethylmagnesium bromide In toluene at -5 - 0℃; Stage #2: With water; acetic acid In toluene for 0.25 - 0.333333h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane; water at -5 - 20℃; |
Conditions | Yield |
---|---|
Stage #1: C13H17NO*(x)ClH With sodium hydroxide In tetrahydrofuran; water at 20 - 25℃; Stage #2: propionic acid anhydride In tetrahydrofuran; water at 20 - 25℃; for 1h; |
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 25℃; |
(S)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetonitrile
ramelteon
Conditions | Yield |
---|---|
With hydrogen; propionic acid anhydride; platinum on activated charcoal In tetrahydrofuran at 60 - 70℃; under 7500.75 - 9000.9 Torr; Product distribution / selectivity; |
(E)-3-(2,3-dihydrobenzofuran-4-yl)acrylaldehyde
ramelteon
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine / ethanol / 16 h / 0 °C 2.1: sodium dihydrogenphosphate; sodium chlorite / 2-methyl-but-2-ene; water; tert-butyl alcohol / 3 h / 20 °C 3.1: thionyl chloride / dichloromethane / 2 h / 60 °C 3.2: 16 h / 0 - 20 °C 4.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C 5.1: sodium hydroxide / methanol; water / 2 h / Reflux 5.2: 0.5 h / 160 °C / Inert atmosphere 6.1: thionyl chloride / toluene / 2 h / 60 °C 7.1: ammonia / dichloromethane / 0.17 h 8.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C 9.1: triethylamine / dichloromethane / 1 h / 20 °C View Scheme |
ramelteon
(S)-N-(2-[4-bromo-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl)propionamide
Conditions | Yield |
---|---|
With bromine; sodium acetate In methanol for 1.5h; Cooling with ice; | 93% |
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical
ramelteon
Conditions | Yield |
---|---|
With pyridine; triisopropylsilyl trifluoromethanesulfonate In hexane at 60℃; for 36h; chemoselective reaction; | 81% |
ramelteon
(S)-N-(2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)ethyl)propan-1-amine hydrochloride
Conditions | Yield |
---|---|
Stage #1: ramelteon With borane-THF In tetrahydrofuran at 20℃; for 2h; Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=7; | 56% |
Stage #1: ramelteon With borane-THF In tetrahydrofuran at 20℃; for 2h; Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=7; | 56% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View