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HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Hunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant

Oseltamivir

Cas:196618-13-0

Min.Order:1 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

196618-13-0 Application:196618-13-0

high quality APIs Oseltamivir cas no 196618-13-0

Cas:196618-13-0

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Oseltamivir Manufacturer/High quality/Best price/In stock

Cas:196618-13-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Oseltamivr supplier in China

Cas:196618-13-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Oseltamivr

Cas:196618-13-0

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Oseltamivir 196618-13-0 GMP Manufacturer

Cas:196618-13-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Oseltamivir

Cas:196618-13-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

OSELTAMIVIR

Cas:196618-13-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Oseltamivir CAS 196618-13-0

Cas:196618-13-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supplyCAS 196618-13-0 with best price

Cas:196618-13-0

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

product Name Oseltamivir Synonyms Oseltamivr; ethyl (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate Molecular Formula C16H28N2O4 Molecul

Oseltamivir

Cas:196618-13-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Qingdao Beluga Import and Export Co., LTD

Oseltamivir CAS:196618-13-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Oseltamivir CAS:196618-13-0

Cas:196618-13-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Oseltamivir

Cas:196618-13-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Top Quality Oseltamivir

Cas:196618-13-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

Factory direct supply Oseltamivir CAS 196618-13-0 AKS

Cas:196618-13-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Oseltamivir

Cas:196618-13-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

OSELTAMIVIR

Cas:196618-13-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Oseltamivir 196618-13-0 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Prof

Oseltamivir 196618-13-0

Cas:196618-13-0

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Hefei Zhaobo Technology Co., Ltd.

Oseltamivir CAS 196618-13-0 Description Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality

Oseltamivir CAS 196618-13-0

Cas:196618-13-0

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Oseltamivir

Cas:196618-13-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

OSELTAMIVIR

Cas:196618-13-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

Manufacturer/High quality Oseltamivir 196618-13-0

Cas:196618-13-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Oseltamivir

Cas:196618-13-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

196618-13-0 OSELTAMIVIR

Cas:196618-13-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our company advantages: Wuhan Han Sheng New Material Technology Co. Ltd 1. Liquid: 0.5liter/bottle, 1liter/bottle, 5liter/bottle, 25liter/box, we use corrosion-resistant chemical liquid packaging plastic barrels . and double layer metal bucket

Oseltamivir Top Quality Oseltamivir/Oseltamivir Phosphate Raw Powder with Best Price

Cas:196618-13-0

Min.Order:1 Kilogram

FOB Price: $20.0 / 60.0

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity Oseltamivir

Cas:196618-13-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Oseltamivir

Cas:196618-13-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: Oseltamivir Phosphate CAS No.:196618-13-0 Molecule Formula:C16H28N2O4 Molecule Weight:312.40 Purity: 99.0% Package: 25kg/drum Description: White or off-white powder Manufacture Standards:Enterprise Standard

High Quality Oseltamivir Phosphate

Cas:196618-13-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

196618-13-0 CAS NO.196618-13-0

Cas:196618-13-0

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Oseltamivir

Cas:196618-13-0

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

ethyl (3R,4R,5S)-4-N-acetylamino-5-N,N-diallylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate

ethyl (3R,4R,5S)-4-N-acetylamino-5-N,N-diallylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 50℃; for 2.21667h;88.7%
Stage #1: ethyl (3R,4R,5S)-4-N-acetylamino-5-N,N-diallylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate With 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine In ethanol at 35℃; for 2h; Inert atmosphere;
Stage #2: With phosphoric acid In acetone for 2h;
83.69%
With tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid
(3R,4R,5S)-ethyl 4-acetamido-5-((tert-butoxycarbonyl)amino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
367252-68-4

(3R,4R,5S)-ethyl 4-acetamido-5-((tert-butoxycarbonyl)amino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 4h; Inert atmosphere;92%
Stage #1: (3R,4R,5S)-ethyl 4-acetamido-5-((tert-butoxycarbonyl)amino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate With hydrogenchloride; water In ethanol at 50℃; for 1h;
Stage #2: With sodium hydrogencarbonate In water
90%
With hydrogenchloride In tetrahydrofuran; ethyl acetate for 0.05h;13.8 mg
ethyl (3R,4R,5S)-4-N-acetylamino-5-N-allylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
312904-18-0

ethyl (3R,4R,5S)-4-N-acetylamino-5-N-allylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With ethanolamine; palladium 10% on activated carbon In ethanol at 20℃; for 3h; Heating / reflux;70%
With palladium on activated charcoal; ethanolamine In ethanol for 3h; Heating;
With ethanolamine; palladium on activated charcoal In ethanol for 3h; Heating;
(1S,2R,3S,4R,5S)-4-acetylamino-3-(1-ethylpropoxy)-5-nitro-2-p-tolylsulfanylcyclohexanecarboxylic acid ethyl ester

(1S,2R,3S,4R,5S)-4-acetylamino-3-(1-ethylpropoxy)-5-nitro-2-p-tolylsulfanylcyclohexanecarboxylic acid ethyl ester

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Stage #1: (1S,2R,3S,4R,5S)-4-acetylamino-3-(1-ethylpropoxy)-5-nitro-2-p-tolylsulfanylcyclohexanecarboxylic acid ethyl ester With chloro-trimethyl-silane; zinc In ethanol at 23 - 70℃; for 2h; Inert atmosphere;
Stage #2: With ammonia In ethanol at 0℃; for 0.166667h;
Stage #3: With potassium carbonate In ethanol at 23℃; for 6h;
85%
Stage #1: (1S,2R,3S,4R,5S)-4-acetylamino-3-(1-ethylpropoxy)-5-nitro-2-p-tolylsulfanylcyclohexanecarboxylic acid ethyl ester With chloro-trimethyl-silane; zinc In ethanol at 70℃; for 2h; Inert atmosphere;
Stage #2: With ammonia In ethanol at 0℃; for 0.166667h; Inert atmosphere;
Stage #3: With potassium carbonate In ethanol at 23℃; for 9h; Inert atmosphere;
81%
Stage #1: (1S,2R,3S,4R,5S)-4-acetylamino-3-(1-ethylpropoxy)-5-nitro-2-p-tolylsulfanylcyclohexanecarboxylic acid ethyl ester With chloro-trimethyl-silane; zinc In ethanol at 70℃; for 2h;
Stage #2: With ammonia; potassium carbonate In ethanol at 20℃; for 6h;
80%
(3R,4R,5S)-4-acetamido-5-(1,3-dioxoisoindol-2-yl)-3-(pentyl-3-yloxy)cyclohexyl-ethyl-1-ene-1-carboxylate
1041262-68-3

(3R,4R,5S)-4-acetamido-5-(1,3-dioxoisoindol-2-yl)-3-(pentyl-3-yloxy)cyclohexyl-ethyl-1-ene-1-carboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With hydrazine In ethanol at 68℃; for 10h;100%
With hydrazine In ethanol at 68℃; for 10h; Inert atmosphere;100%
With hydrazine In ethanol at 68℃; for 11h; Schlenk technique; Inert atmosphere;86%
(3R,4R,5S)-4-acetamido-5-allyloxycarbonylamino-1-ethoxycarbonyl-3-(3-pentyloxy)cyclohex-1-ene

(3R,4R,5S)-4-acetamido-5-allyloxycarbonylamino-1-ethoxycarbonyl-3-(3-pentyloxy)cyclohex-1-ene

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With pyrrolidine; tetrakis(triphenylphosphine) palladium(0) In ethanol for 0.5h;95.1%
With 1,3-dimethylbarbituric acid; triphenylphosphine; palladium on activated charcoal In ethanol; water at 80℃; for 1h;
(3R,4R,5S)-ethyl-4-(N-acetylacetamide)-5-(1,3-dioxoisoindolin-2-yl)-3-(3-pentyloxy)cyclohex-1-ene carboxylate
1197396-47-6

(3R,4R,5S)-ethyl-4-(N-acetylacetamide)-5-(1,3-dioxoisoindolin-2-yl)-3-(3-pentyloxy)cyclohex-1-ene carboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Stage #1: (3R,4R,5S)-ethyl-4-(N-acetylacetamide)-5-(1,3-dioxoisoindolin-2-yl)-3-(3-pentyloxy)cyclohex-1-ene carboxylate With hydrazine hydrate In ethanol at 50℃; for 14h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In ethanol
Stage #3: With ammonium hydroxide In water pH=11;
96%
C21H36N2O6

C21H36N2O6

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With trifluoroacetic acid In isopropyl alcohol at 0 - 30℃; for 7h; Solvent; Reagent/catalyst; Temperature;96%
oseltamivir
204255-06-1

oseltamivir

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With hydrogen at 20℃; under 380.026 Torr; for 3h;98.5%
With tributylphosphine; acetic acid In ethanol; water at 5 - 25℃; for 5.5 - 9h;97%
With triphenylphosphine In tetrahydrofuran; water at 50℃; for 10h;96%
(1S,2R,3S,4R,5S)-ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexanecarboxylate

(1S,2R,3S,4R,5S)-ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexanecarboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With potassium carbonate In ethanol at 23℃; for 4h; retro Michael reaction;91%
With potassium carbonate In ethanol at 23℃; for 4h; Product distribution / selectivity;91%
Stage #1: (1S,2R,3S,4R,5S)-ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexanecarboxylate With ammonia In ethanol at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: With potassium carbonate In ethanol at 23℃; for 6h; Inert atmosphere;
45.2 mg
oseltamivir phosphate
204255-11-8

oseltamivir phosphate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 20℃; for 0.0833333h; Inert atmosphere;98%
Stage #1: oseltamivir phosphate In dichloromethane; water at 25 - 30℃; for 0.166667h;
Stage #2: With ammonia In dichloromethane; water pH=9 - 10;
Stage #3: In n-heptane at 25 - 30℃; for 1h; Purification / work up;
Stage #1: oseltamivir phosphate In dichloromethane; water at 25 - 30℃; for 0.166667h;
Stage #2: With ammonia In dichloromethane; water pH=9 - 10;
Stage #3: In n-heptane; toluene at 20 - 30℃; for 3.5h; Purification / work up;
In dichloromethane; water at 20℃; for 0.75h;
ethyl (3R,4R,5S)-4-N-acetyl(1,1-dimethylethyl)amino-5-N,N-diallylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
651324-07-1

ethyl (3R,4R,5S)-4-N-acetyl(1,1-dimethylethyl)amino-5-N,N-diallylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; ethanol / 13 - 25 °C
2: trifluoroacetic acid / 1.5 h / 50 °C
3: 1,3-dimethylbarbituric acid; triphenylphosphine; palladium diacetate / ethanol / 2 h / 35 °C / Sealed tube; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 1 h / 50 °C
2: 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine / ethanol / 2 h / 20 - 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine / ethanol / 2 h / 20 - 25 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 2 h / 35 - 40 °C
View Scheme
With 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine In ethanol; water at 50℃;
C20H36N2O4

C20H36N2O4

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 35 - 40℃; for 2h;
With trifluoroacetic acid In dichloromethane at 50℃; for 2h; Reagent/catalyst; Solvent;
tert-butyl [(1S,5R,6R)-6-acetylamino-3-cyano-5-(1-ethylpropoxy)cyclohex-3-en-1-yl]carbamate
891831-22-4

tert-butyl [(1S,5R,6R)-6-acetylamino-3-cyano-5-(1-ethylpropoxy)cyclohex-3-en-1-yl]carbamate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Stage #1: tert-butyl [(1S,5R,6R)-6-acetylamino-3-cyano-5-(1-ethylpropoxy)cyclohex-3-en-1-yl]carbamate With hydrogenchloride In ethanol at 60℃; for 4h;
Stage #2: With water In ethanol at 4℃; for 3h;
53%
(3R,4R)-ethyl 4-acetamido-5-nitro-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate

(3R,4R)-ethyl 4-acetamido-5-nitro-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate

A

ethyl (3R,4R,5R)-4-acetylamino-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
1402431-91-7

ethyl (3R,4R,5R)-4-acetylamino-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

B

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With chloro-trimethyl-silane; ethanol; zinc In tetrahydrofuran; toluene at 70℃; for 2h; Flow reactor;A n/a
B n/a
C19H35N2O4P
1362750-80-8

C19H35N2O4P

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Stage #1: C19H35N2O4P With hydrogenchloride; water In dichloromethane; toluene at 20℃; for 4h;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water; toluene pH=10;
53.2 mg
(3R,4R,5S)-ethyl 4-acetylamino-3-(pentan-3-yloxy)-5-(2,2,2-trichloroacetamido)cyclohex-1-enecarboxylate
1443055-49-9

(3R,4R,5S)-ethyl 4-acetylamino-3-(pentan-3-yloxy)-5-(2,2,2-trichloroacetamido)cyclohex-1-enecarboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Stage #1: (3R,4R,5S)-ethyl 4-acetylamino-3-(pentan-3-yloxy)-5-(2,2,2-trichloroacetamido)cyclohex-1-enecarboxylate With caesium carbonate In dimethyl sulfoxide at 80℃; for 0.25h;
Stage #2: With acetic acid In water; dimethyl sulfoxide at 80℃; for 0.333333h;
ethyl (3R,4R,5S)-4-acetamido-5-nitro-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
949164-64-1

ethyl (3R,4R,5S)-4-acetamido-5-nitro-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With acetic acid; zinc at 20℃; for 34h; Inert atmosphere;81%
Stage #1: ethyl (3R,4R,5S)-4-acetamido-5-nitro-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate With acetic acid; zinc In ethanol at 70℃; Inert atmosphere; Reflux;
Stage #2: With ammonium hydroxide In ethanol; water at 20℃; pH=8; Inert atmosphere;
71%
With hydrogenchloride In water at 50℃; for 1h; Inert atmosphere;
With chloro-trimethyl-silane; acetic acid; zinc In diethyl ether for 8h; Reflux;
(3R,4R,5S)-4-acetylamino-5-benzyloxycarbonylamino-1-cyano-3-(1-ethylpropoxy)cyclohexene
927395-63-9

(3R,4R,5S)-4-acetylamino-5-benzyloxycarbonylamino-1-cyano-3-(1-ethylpropoxy)cyclohexene

ethanol
64-17-5

ethanol

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Stage #1: (3R,4R,5S)-4-acetylamino-5-benzyloxycarbonylamino-1-cyano-3-(1-ethylpropoxy)cyclohexene; ethanol With hydrogenchloride at 20℃; for 24h;
Stage #2: With water In ethanol at 20℃; for 2h;
Stage #3: With ammonium hydroxide In ethanol at 20℃; for 10h;
74%
ethyl (3R,4R,5R,6R)-4-acetamido-5-azido-6-(methylsulfonyloxy)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
1196490-17-1

ethyl (3R,4R,5R,6R)-4-acetamido-5-azido-6-(methylsulfonyloxy)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate

A

C16H27NO4
1196490-21-7

C16H27NO4

B

ethyl (3S,4R,5R)-4-acetamido-3-amino-5-(pentan-3-yloxy)-cyclohex-1-enecarboxylate
1052063-39-4

ethyl (3S,4R,5R)-4-acetamido-3-amino-5-(pentan-3-yloxy)-cyclohex-1-enecarboxylate

C

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran; ethanol at -30 - 20℃;
(1S,5R,6S)-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester
204254-96-6

(1S,5R,6S)-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 97 percent / MgBr2*OEt2 / acetonitrile; various solvent(s) / 16 h / 55 °C
2.1: ethanolamine; Pd/C / ethanol / 3 h / Heating
2.2: 77 percent / H2SO4
3.1: various solvent(s)
4.1: Et3N / various solvent(s)
5.1: various solvent(s) / 15 h / 111 - 112 °C / 2625.21 - 3375.27 Torr
6.1: AcOH; MeSO3H / various solvent(s) / 15 h / 20 °C
7.1: NH2CH2CH2OH; Pd/C / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 7 steps
1.1: MgBr2*OEt2 / acetonitrile; various solvent(s) / Heating
1.2: H2NCH2CH2OH / Pd/C / ethanol / 3 h / Heating
2.1: 6 h / 100 °C / 750.08 - 3750.38 Torr
3.1: Et3N / ethyl acetate / 0 - 20 °C
4.1: MeSO3H / ethanol / 2.67 h / Heating
5.1: ethyl acetate / 6 h / 112 °C / 750.08 - 4500.45 Torr
6.1: AcOH; MeSO3H / various solvent(s) / 0 - 20 °C
7.1: H2NCH2CH2OH / Pd/C / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 7 steps
1.1: MgBr2*OEt2 / acetonitrile; various solvent(s) / Heating
1.2: H2NCH2CH2OH / Pd/C / ethanol / 3 h / Heating
2.1: 6 h / 100 °C / 750.08 - 3750.38 Torr
3.1: Et3N / ethyl acetate / 0 - 20 °C
4.1: MeSO3H / ethanol / 2.67 h / Heating
5.1: ethyl acetate / 6 h / 112 °C / 750.08 - 4500.45 Torr
6.1: AcOH; MeSO3H / various solvent(s) / 0 - 20 °C
7.1: HOCH2CH2OH / Pd/C / ethanol / Heating
View Scheme
ethyl (3R,4S,5R)-5-amino-3-(1-ethylpropoxy)-4-hydroxy-1-cyclohexene-1-carboxylate
312904-12-4

ethyl (3R,4S,5R)-5-amino-3-(1-ethylpropoxy)-4-hydroxy-1-cyclohexene-1-carboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: various solvent(s)
2: Et3N / various solvent(s)
3: various solvent(s) / 15 h / 111 - 112 °C / 2625.21 - 3375.27 Torr
4: AcOH; MeSO3H / various solvent(s) / 15 h / 20 °C
5: NH2CH2CH2OH; Pd/C / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: 6 h / 100 °C / 750.08 - 3750.38 Torr
2: Et3N / ethyl acetate / 0 - 20 °C
3: MeSO3H / ethanol / 2.67 h / Heating
4: ethyl acetate / 6 h / 112 °C / 750.08 - 4500.45 Torr
5: AcOH; MeSO3H / various solvent(s) / 0 - 20 °C
6: H2NCH2CH2OH / Pd/C / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: 6 h / 100 °C / 750.08 - 3750.38 Torr
2: Et3N / ethyl acetate / 0 - 20 °C
3: MeSO3H / ethanol / 2.67 h / Heating
4: ethyl acetate / 6 h / 112 °C / 750.08 - 4500.45 Torr
5: AcOH; MeSO3H / various solvent(s) / 0 - 20 °C
6: HOCH2CH2OH / Pd/C / ethanol / Heating
View Scheme
Multi-step reaction with 6 steps
1: acetonitrile / 1 h / 35 °C
2: pyridine / chloroform / 3 h / -5 °C
3: pyridine / tert-butyl methyl ether / 10 h / 80 °C
4: hydrogen; palladium on activated charcoal / ethanol / 8 h / 35 °C / 760.05 Torr
5: tert-butyl methyl ether / 2 h / 40 °C
6: trifluoroacetic acid / isopropyl alcohol / 7 h / 0 - 30 °C
View Scheme
2-pentanol
584-02-1

2-pentanol

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: BF3*Et2O / 2 h / 70 - 75 °C
2: pyridine, (dimethylamino)pyridine / 18 h / Ambient temperature
3: Ph3P, H2O / tetrahydrofuran / 10 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: boron trifluoride diethyl etherate / 75 °C / Inert atmosphere
2: pyridine; dmap / 1 h / 150 °C / Inert atmosphere; Microwave irradiation
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
4: hydrazine / ethanol / 10 h / 68 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: boron trifluoride diethyl etherate / 75 °C / Inert atmosphere
2: pyridine; dmap / 1 h / 150 °C / Inert atmosphere; Microwave irradiation
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
4: hydrazine / ethanol / 10 h / 68 °C / Inert atmosphere
View Scheme
C24H34N2O6
1158724-89-0

C24H34N2O6

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; ethanol at 20℃; for 24h;83%
2-(1-ethylpropoxy)acetaldehyde
1141364-90-0

2-(1-ethylpropoxy)acetaldehyde

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; chloroacetic acid / toluene
2.1: caesium carbonate / 4 h / 0 - 20 °C
3.1: -15 °C
4.1: trifluoroacetic acid / toluene / 4 h / 20 °C
5.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 0.33 h / 20 °C
6.1: trimethylsilylazide / toluene / 0.33 h / 20 °C
7.1: acetic acid / 48 h / 20 °C
8.1: chloro-trimethyl-silane; zinc / ethanol / 70 °C
8.2: 0 °C
9.1: potassium carbonate / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; chloroacetic acid / toluene / 6 h / 23 °C / Inert atmosphere
1.2: 2 h / 23 °C / Inert atmosphere
2.1: trifluoroacetic acid / toluene / 4 h / 23 °C / Inert atmosphere
3.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 0.5 h / 23 °C / Inert atmosphere
4.1: pyridine; trimethylsilylazide / N,N-dimethyl-formamide / 20 °C / Microflow reaction; Inert atmosphere
4.2: 110 °C / Microflow reaction; Inert atmosphere
5.1: chloro-trimethyl-silane; zinc / ethanol / 2 h / 70 °C / Inert atmosphere
5.2: 0.17 h / 0 °C / Inert atmosphere
5.3: 9 h / 23 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; chloroacetic acid / dimethyl sulfoxide / 20 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 70 °C / Inert atmosphere
3: acetic acid; zinc / 34 h / 20 °C / Inert atmosphere
View Scheme
N-((2R,3S)-1-nitro-4-oxo-3-(pentan-3-yloxy)butan-2-yl)acetamide
1226768-14-4

N-((2R,3S)-1-nitro-4-oxo-3-(pentan-3-yloxy)butan-2-yl)acetamide

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: caesium carbonate / 3 h / 0 °C
2: 36 h / -15 °C
3: chloro-trimethyl-silane; zinc / 2 h / -15 - 70 °C
4: ammonia; potassium carbonate / 14 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: caesium carbonate / 3 h / 0 °C
1.2: 1 h
2.1: 36 h / -15 °C
3.1: chloro-trimethyl-silane; zinc / 2 h / -15 - 70 °C
4.1: ammonia; potassium carbonate / 14 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / acetonitrile / 3 h / 0 - 20 °C
2: zinc; acetic acid / ethanol / 0.5 h / 70 °C / Inert atmosphere
3: acetonitrile / 4 h / 20 °C
4: lithium chloride / dimethyl sulfoxide / 2 h / 190 °C / Inert atmosphere
5: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere
View Scheme
tert-butyl [(1S,5R,6R)-6-acetylamino-3-cyano-5-(1-ethylpropoxy)cyclohex-3-en-1-yl]carbamate
891831-22-4

tert-butyl [(1S,5R,6R)-6-acetylamino-3-cyano-5-(1-ethylpropoxy)cyclohex-3-en-1-yl]carbamate

ethanol
64-17-5

ethanol

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Stage #1: tert-butyl [(1S,5R,6R)-6-acetylamino-3-cyano-5-(1-ethylpropoxy)cyclohex-3-en-1-yl]carbamate; ethanol With hydrogenchloride at 20℃; for 24h;
Stage #2: With water at 4 - 20℃; for 7.5h;
60%
ethyl (3R,4R,5S)-5-N-allylamino-4-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
312904-15-7

ethyl (3R,4R,5S)-5-N-allylamino-4-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: AcOH; MeSO3H / various solvent(s) / 15 h / 20 °C
2: NH2CH2CH2OH; Pd/C / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: AcOH; MeSO3H / various solvent(s) / 0 - 20 °C
2: H2NCH2CH2OH / Pd/C / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: AcOH; MeSO3H / various solvent(s) / 0 - 20 °C
2: HOCH2CH2OH / Pd/C / ethanol / Heating
View Scheme
argon

argon

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

1-amino-2-propene
107-11-9

1-amino-2-propene

A

oseltamivir
196618-13-0

oseltamivir

B

ethyl (3R,4R,5S)-5-N-allylamino-4-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
312904-15-7

ethyl (3R,4R,5S)-5-N-allylamino-4-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate

Conditions
ConditionsYield
With sodium sulfate In ethyl acetate
(3R,4S,5R)-4-acetylamino-3-(1-ethyl-propoxy)-5-methanesulfonyloxy-cyclohex-1-enecarboxylic acid ethyl ester
1132659-99-4

(3R,4S,5R)-4-acetylamino-3-(1-ethyl-propoxy)-5-methanesulfonyloxy-cyclohex-1-enecarboxylic acid ethyl ester

oseltamivir
196618-13-0

oseltamivir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 °C
2: water; triphenylphosphine / tetrahydrofuran / 8 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C
2: hydrogen / ethanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium azide / ethanol; water / 8 h / Reflux
2.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C
2.2: Staudinger Azide Reduction / 24 h / 20 °C
View Scheme
1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine
207857-15-6

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

oseltamivir
196618-13-0

oseltamivir

(3R,4R,5S)-5-[[(1Z)-[[(tert-butoxy)carbonyl]amino]([[(tert-butoxy)carbonyl]imino])methyl]amino]-4-acetylamino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid ethyl ester
208720-81-4

(3R,4R,5S)-5-[[(1Z)-[[(tert-butoxy)carbonyl]amino]([[(tert-butoxy)carbonyl]imino])methyl]amino]-4-acetylamino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
oseltamivir
196618-13-0

oseltamivir

oseltamivir acid

oseltamivir acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 90℃; for 2h;99%
Stage #1: oseltamivir With potassium hydroxide; water In tetrahydrofuran at 0 - 20℃; for 1h;
Stage #2: With Amberlite IR-120 In tetrahydrofuran pH=5;
88%
Stage #1: oseltamivir With potassium hydroxide In methanol; water
Stage #2: In methanol; water for 0.0833333h;
79%
oseltamivir
196618-13-0

oseltamivir

oseltamivir
204255-06-1

oseltamivir

Conditions
ConditionsYield
With fluorosulfonyl azide; potassium hydrogencarbonate In tert-butyl methyl ether; water; N,N-dimethyl-formamide at 20℃; for 0.5h;99%
oseltamivir
196618-13-0

oseltamivir

oseltamivir phosphate
204255-11-8

oseltamivir phosphate

Conditions
ConditionsYield
With phosphoric acid In ethanol at 50℃; for 0.0166667h; Sonication;98%
With phosphoric acid In ethanol at -18.8℃; for 17h;89.9%
With phosphoric acid In ethanol at 50 - 55℃;88.6%
2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

oseltamivir
196618-13-0

oseltamivir

(3R,4R,5S)-4-acetylamino-5-trifluoroacetylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester

(3R,4R,5S)-4-acetylamino-5-trifluoroacetylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With copper(l) iodide; 9-azabicyclo<3.3.1>nonane-N-oxyl; oxygen; 4,4'-di-tert-butyl-2,2'-bipyridine In acetonitrile at 20℃; under 760.051 Torr; for 4h; Sealed tube;90%
tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate
145013-05-4

tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate

oseltamivir
196618-13-0

oseltamivir

ethyl (3R,4R,5S)-4-acetamido-5-[N2,N3-bis(tert-butoxycarbonyl)guanidino]-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate

ethyl (3R,4R,5S)-4-acetamido-5-[N2,N3-bis(tert-butoxycarbonyl)guanidino]-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate

Conditions
ConditionsYield
With triethylamine; mercury dichloride In N,N-dimethyl-formamide at 0℃;89%
With triethylamine In N,N-dimethyl-formamide at 0 - 20℃;89%
With triethylamine; mercury dichloride In N,N-dimethyl-formamide at 20℃; for 10h;177 mg
phosphoric acid
86119-84-8, 7664-38-2

phosphoric acid

oseltamivir
196618-13-0

oseltamivir

oseltamivir phosphate
204255-11-8

oseltamivir phosphate

Conditions
ConditionsYield
In ethanol; water at 50 - 55℃; for 1.5 - 2h;88%
2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester
19350-66-4

2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester

oseltamivir
196618-13-0

oseltamivir

diethyl 4-(((1S,5R,6R)-6-acetamido-3-(ethoxycarbonyl)-5-(pentan-3-yloxy)cyclohex-3-en-1-yl)carbamoyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

diethyl 4-(((1S,5R,6R)-6-acetamido-3-(ethoxycarbonyl)-5-(pentan-3-yloxy)cyclohex-3-en-1-yl)carbamoyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Conditions
ConditionsYield
Stage #1: 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester With triethylamine; isobutyl chloroformate In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: oseltamivir In dichloromethane at 20℃; Inert atmosphere;
87%
tert-butyldicarbonate
34619-03-9

tert-butyldicarbonate

oseltamivir
196618-13-0

oseltamivir

(3R,4R,5S)-ethyl 4-acetamido-5-((tert-butoxycarbonyl)amino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
367252-68-4

(3R,4R,5S)-ethyl 4-acetamido-5-((tert-butoxycarbonyl)amino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate

Conditions
ConditionsYield
With triethylamine In methanol at 0 - 20℃; for 18h;86%
With triethylamine In methanol at 0 - 20℃; for 18h;86%
5-bromo-2-chloro-3-nitropyridine
67443-38-3

5-bromo-2-chloro-3-nitropyridine

oseltamivir
196618-13-0

oseltamivir

(3R,4R,5S)-4-acetamido-5-[2-(5-bromo-3-nitro)pyridinylamino]-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester

(3R,4R,5S)-4-acetamido-5-[2-(5-bromo-3-nitro)pyridinylamino]-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃;82%
oseltamivir
196618-13-0

oseltamivir

C16H28N2O4*H3O4P

C16H28N2O4*H3O4P

Conditions
ConditionsYield
With phosphoric acid In ethanol; water at 65 - 75℃; for 8h; pH=4; Temperature; pH-value;81.9%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

oseltamivir
196618-13-0

oseltamivir

C17H30N2O6S

C17H30N2O6S

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h;80%
With triethylamine In dichloromethane at 0℃;
hexyloxycarbonyl isothiocyanate

hexyloxycarbonyl isothiocyanate

oseltamivir
196618-13-0

oseltamivir

(3R,4R,5S)-4-acetamido-5-[N-(N′-n-hexyloxycarbonyl)thioureido]-3-(1-ethylpropoxy)-cyclohex-1-en-1-carboxylic acid ethyl ester

(3R,4R,5S)-4-acetamido-5-[N-(N′-n-hexyloxycarbonyl)thioureido]-3-(1-ethylpropoxy)-cyclohex-1-en-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h;75%
acetic acid
64-19-7

acetic acid

oseltamivir
196618-13-0

oseltamivir

(3R,4R,5S)-4-acetylamino-5-acetylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester
1191921-01-3

(3R,4R,5S)-4-acetylamino-5-acetylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate at 20℃;74.5%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃;

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