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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Manufacturer/High quality/Best price/In stock

Cas:196597-78-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Hangzhou Dingyan Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best qua

High purity 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one with high quality and best price cas:196597-78-1

Cas:196597-78-1

Min.Order:1 Kilogram

FOB Price: $1800.0 / 2400.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1200.html Product Name 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one CAS No.

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one CAS No.:196597-78-1 Name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Molecular Structure: Molecular Formula: C11H10O2 Molecular Weight: 174.2 CAS Reg

High purity 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one CAS No.:196597-78-1

Cas:196597-78-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1,2,6,7-Tetrahydro-8H-Indeno[5,4-B]Furan-8-One

Cas:196597-78-1

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Product Name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Synonyms: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one;1,2,6,7-Tetrahydro-8H-indeno[5,4-β]furan-8-one;1,2,6,7-tetrahydroindeno[5,4-b]furan-8-one;Ramelteon Inte

196597-78-1 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:1 Kilogram

FOB Price: $8900.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Best PurityCAS 196597-78-1 with best price

Cas:196597-78-1

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one CAS196597-78-1

Cas:196597-78-1

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Synonyms: 1,2,6,7-Tetrahydro-8H-indeno[5,4-β]furan-8-one CAS:196597-78-1 MF: C11H10O2 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one CAS:196597-78-1

Cas:196597-78-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one 196597-78-1

Cas:196597-78-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one CAS:196597-78-1

Cas:196597-78-1

Min.Order:1 Gram

FOB Price: $16.0 / 19.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one CAS:196597-78-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one CAS:196597-78-1

Cas:196597-78-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one cas:196597-78-1

Cas:196597-78-1

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

1,2,6,7-Tetrahydro-8H-Indeno[5,4-B]Furan-8-One

Cas:196597-78-1

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

1,2,6,7-TETRAHYDRO-8H-INDENO[5,4-B]FURAN-8-ONE

Cas:196597-78-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:1 Gram

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one Synonyms: 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one;1,2,6,7-Tetrahydro-8H-indeno[5,4-β]furan-8-one;RaMelteon I;4-b]furan-8-one;7-tetrahydro-;8H-Indeno[5;1,2,6,7-tetrahydroin

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one

Cas:196597-78-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Changchun Artel lmport and Export trade company

My Company Changchun Artel Import and Export trade companyImport and Export Trade Co., Ltd.is located in Changchun, a national historical and cultural city, Jilin Province, China. It covers an area of 22,000 square meters, construction area

1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one CAS NO.196597-78-1

Cas:196597-78-1

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Synthetic route

1-(2,3-dihydrobenzofuran-4-yl)-2-propen-1-one
1205098-83-4

1-(2,3-dihydrobenzofuran-4-yl)-2-propen-1-one

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate) In 1,2-dichloro-ethane at 10 - 20℃; for 16h; Solvent; Reagent/catalyst;96.3%
With sulfuric acid In pentane at 67℃; Product distribution / selectivity; Inert atmosphere;
With sulfuric acid In water; pentane at 67℃; for 0.5h; Inert atmosphere;
4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one
196597-77-0

4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
With hydrogen; acetic acid; 10percent Pd/C/H2O at 20℃; for 1h;89%
With hydrogen; sodium acetate; 5% palladium over charcoal In water; acetic acid at 20℃;89%
With hydrogen; sodium acetate; palladium 10% on activated carbon In methanol at 40℃; under 2175.22 - 3675.37 Torr; for 8h;88.6%
4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one
196597-77-0

4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

A

C11H12O
1092507-06-6

C11H12O

B

2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-ol
1092507-07-7

2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-ol

C

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
With hydrogen; sodium acetate; acetic acid; palladium 10% on activated carbon under 1471.14 - 2206.72 Torr;A n/a
B n/a
C 85%
6,7-dihydro-8H-indeno-[5,4-b]furan-8-one
15480-25-8

6,7-dihydro-8H-indeno-[5,4-b]furan-8-one

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
With hydrogen; 5% Pd(II)/C(eggshell); triethylamine In tetrahydrofuran; ethanol at 35℃; under 4500.45 - 5250.53 Torr; for 24h;62%
4-tert-butyl-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one
1198465-69-8

4-tert-butyl-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
With hydrogenchloride; aluminum (III) chloride In benzene20%
2,3-Dihydrobenzofuran
496-16-2

2,3-Dihydrobenzofuran

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 92 percent / TiCl4 / CH2Cl2 / 1 h
2.1: NaH / tetrahydrofuran / 0.33 h / 20 °C
2.2: 88 percent / tetrahydrofuran / 1 h / 20 °C
3.1: 99 percent / H2 / 10percent Pd/C/H2O / ethanol / 2 h / 20 °C
4.1: 97 percent / NaOAc; AcOH; Br2 / 1 h / 20 °C
5.1: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C
6.1: 93 percent / aq. KOH / ethanol / 1 h / 90 °C
7.1: SOCl2 / 75 °C
8.1: AlCl3 / 1,2-dichloro-ethane / 20 °C
9.1: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C
View Scheme
Multi-step reaction with 9 steps
1.1: 86 percent / POCl3 / 12 h / 80 - 85 °C
2.1: NaH / tetrahydrofuran / 0.33 h / 20 °C
2.2: 88 percent / tetrahydrofuran / 1 h / 20 °C
3.1: 99 percent / H2 / 10percent Pd/C/H2O / ethanol / 2 h / 20 °C
4.1: 97 percent / NaOAc; AcOH; Br2 / 1 h / 20 °C
5.1: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C
6.1: 93 percent / aq. KOH / ethanol / 1 h / 90 °C
7.1: SOCl2 / 75 °C
8.1: AlCl3 / 1,2-dichloro-ethane / 20 °C
9.1: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: trichlorophosphate / 5.17 h / 30 - 98 °C
2.1: sodium methylate / toluene / 0.25 h / 0 - 30 °C
3.1: hydrogen / nickel / methanol / 4 h / 50 °C
4.1: bromine; sodium acetate; acetic acid / 14 h / 20 - 28 °C
5.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C
5.2: 1 h / -5 - 5 °C
6.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C
View Scheme
2,3-dihydro-benzofuran-5-carbaldehyde
55745-70-5

2,3-dihydro-benzofuran-5-carbaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: NaH / tetrahydrofuran / 0.33 h / 20 °C
1.2: 88 percent / tetrahydrofuran / 1 h / 20 °C
2.1: 99 percent / H2 / 10percent Pd/C/H2O / ethanol / 2 h / 20 °C
3.1: 97 percent / NaOAc; AcOH; Br2 / 1 h / 20 °C
4.1: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C
5.1: 93 percent / aq. KOH / ethanol / 1 h / 90 °C
6.1: SOCl2 / 75 °C
7.1: AlCl3 / 1,2-dichloro-ethane / 20 °C
8.1: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium methylate / toluene / 0.25 h / 0 - 30 °C
2.1: hydrogen / nickel / methanol / 4 h / 50 °C
3.1: bromine; sodium acetate; acetic acid / 14 h / 20 - 28 °C
4.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C
4.2: 1 h / -5 - 5 °C
5.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: piperidine; pyridine / 6 h / 120 °C
2.1: thionyl chloride / 0.67 h / 26 - 73 °C / Heating / reflux
3.1: hydrogen / nickel / methanol / 4 h / 50 °C
4.1: bromine; sodium acetate; acetic acid / 14 h / 20 - 28 °C
5.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C
5.2: 1 h / -5 - 5 °C
6.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C
View Scheme
Multi-step reaction with 5 steps
1.1: piperidine; pyridine; acetic acid / 4 - 5 h / 100 °C
1.2: 2 - 3 h / 20 °C
2.1: sodium hydroxide; hydrogen; ammonium formate / palladium 10% on activated carbon / water / 5 - 6 h / 20 °C
3.1: bromine; sodium acetate; acetic acid / 2 - 3 h / 0 - 45 °C
4.1: thionyl chloride / N,N-dimethyl-formamide / 1 - 2 h / 20 °C
4.2: 1 - 2 h / 0 - 5 °C
5.1: hydrogen; sodium acetate; acetic acid / palladium 10% on activated carbon / 1471.14 - 2206.72 Torr
View Scheme
Multi-step reaction with 6 steps
1: sodium t-butanolate / toluene / 1 h
2: acetic acid; hydrogen; 5%-palladium/activated carbon / 1 h / 50 °C / 1470.15 - 2205.22 Torr
3: acetic acid; sodium acetate; bromine / 6 h / 20 °C / Cooling
4: thionyl chloride / 1,2-dichloro-benzene; N,N-dimethyl-formamide / 42 °C
5: aluminum (III) chloride / 0.5 h / Cooling with ice
6: hydrogen; sodium acetate; palladium 10% on activated carbon / methanol / 2 h / 40 °C / 2205.22 - 3675.37 Torr
View Scheme
ethyl (E)-3-(2,3-dihydrobenzofuran-5-yl)-2-propenoate
196597-65-6

ethyl (E)-3-(2,3-dihydrobenzofuran-5-yl)-2-propenoate

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 99 percent / H2 / 10percent Pd/C/H2O / ethanol / 2 h / 20 °C
2: 97 percent / NaOAc; AcOH; Br2 / 1 h / 20 °C
3: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C
4: 93 percent / aq. KOH / ethanol / 1 h / 90 °C
5: SOCl2 / 75 °C
6: AlCl3 / 1,2-dichloro-ethane / 20 °C
7: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: acetic acid; hydrogen; 5%-palladium/activated carbon / 1 h / 50 °C / 1470.15 - 2205.22 Torr
2: acetic acid; sodium acetate; bromine / 6 h / 20 °C / Cooling
3: thionyl chloride / 1,2-dichloro-benzene; N,N-dimethyl-formamide / 42 °C
4: aluminum (III) chloride / 0.5 h / Cooling with ice
5: hydrogen; sodium acetate; palladium 10% on activated carbon / methanol / 2 h / 40 °C / 2205.22 - 3675.37 Torr
View Scheme
ethyl 3-(2,3-dihydro-1-benzofuran-5-yl)propanoate
196597-66-7

ethyl 3-(2,3-dihydro-1-benzofuran-5-yl)propanoate

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 97 percent / NaOAc; AcOH; Br2 / 1 h / 20 °C
2: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C
3: 93 percent / aq. KOH / ethanol / 1 h / 90 °C
4: SOCl2 / 75 °C
5: AlCl3 / 1,2-dichloro-ethane / 20 °C
6: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: bromine; sodium acetate; acetic acid / 14 h / 20 - 28 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C
2.2: 1 h / -5 - 5 °C
3.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: acetic acid; sodium acetate; bromine / 6 h / 20 °C / Cooling
2: thionyl chloride / 1,2-dichloro-benzene; N,N-dimethyl-formamide / 42 °C
3: aluminum (III) chloride / 0.5 h / Cooling with ice
4: hydrogen; sodium acetate; palladium 10% on activated carbon / methanol / 2 h / 40 °C / 2205.22 - 3675.37 Torr
View Scheme
ethyl 3-(7-bromo-2,3-dihydro-1-benzofuran-5-yl)propanoate
196597-67-8

ethyl 3-(7-bromo-2,3-dihydro-1-benzofuran-5-yl)propanoate

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 53 percent / AcOH; Fe; Br2 / 5 h / 50 °C
2: 93 percent / aq. KOH / ethanol / 1 h / 90 °C
3: SOCl2 / 75 °C
4: AlCl3 / 1,2-dichloro-ethane / 20 °C
5: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C
View Scheme
3-(6,7-dibromo-2,3-dihydro-benzofuran-5-yl)-propionyl chloride
227179-21-7

3-(6,7-dibromo-2,3-dihydro-benzofuran-5-yl)-propionyl chloride

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: AlCl3 / 1,2-dichloro-ethane / 20 °C
2: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: aluminum (III) chloride / 0.5 h / Cooling with ice
2: hydrogen; sodium acetate; palladium 10% on activated carbon / methanol / 2 h / 40 °C / 2205.22 - 3675.37 Torr
View Scheme
ethyl 3-(6,7-dibromo-2,3-dihydrobenzofuran-5-yl) propionic acid
196597-76-9

ethyl 3-(6,7-dibromo-2,3-dihydrobenzofuran-5-yl) propionic acid

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SOCl2 / 75 °C
2: AlCl3 / 1,2-dichloro-ethane / 20 °C
3: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C
1.2: 1 h / -5 - 5 °C
2.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C
View Scheme
Multi-step reaction with 2 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 1 - 2 h / 20 °C
1.2: 1 - 2 h / 0 - 5 °C
2.1: hydrogen; sodium acetate; acetic acid / palladium 10% on activated carbon / 1471.14 - 2206.72 Torr
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / 1,2-dichloro-benzene; N,N-dimethyl-formamide / 42 °C
2: aluminum (III) chloride / 0.5 h / Cooling with ice
3: hydrogen; sodium acetate; palladium 10% on activated carbon / methanol / 2 h / 40 °C / 2205.22 - 3675.37 Torr
View Scheme
ethyl 3-(6,7-dibromo-2,3-dihydro-1-benzofuran-5-yl)propanoate
196597-75-8

ethyl 3-(6,7-dibromo-2,3-dihydro-1-benzofuran-5-yl)propanoate

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / aq. KOH / ethanol / 1 h / 90 °C
2: SOCl2 / 75 °C
3: AlCl3 / 1,2-dichloro-ethane / 20 °C
4: 89 percent / AcOH; H2 / 10percent Pd/C/H2O / 1 h / 20 °C
View Scheme
6-hydroxy-7-(2-mesyloxyethyl)indan-1-one
1198465-72-3

6-hydroxy-7-(2-mesyloxyethyl)indan-1-one

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
With triethylamine In ethyl acetate for 3h; Reflux;4.47 g
formaldehyd
50-00-0

formaldehyd

1-(dihydrobenzofuran-4-yl)ethanone
1205098-82-3

1-(dihydrobenzofuran-4-yl)ethanone

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Stage #1: formaldehyd; 1-(dihydrobenzofuran-4-yl)ethanone With dicyclohexylammonium trifloroacetate In 1,4-dioxane at 100℃; for 4h;
Stage #2: With sulfuric acid In pentane at 67℃; Inert atmosphere;
6-hydroxy-1-indanone
62803-47-8

6-hydroxy-1-indanone

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 5 h / Reflux
2.1: N,N-dimethyl-aniline / Inert atmosphere; Reflux
2.2: 25 °C
3.1: ozone / dichloromethane / -78 - 20 °C / Inert atmosphere
3.2: 20 °C
4.1: toluene-4-sulfonic acid / toluene / 0.75 h / Reflux
5.1: hydrogen / triethylamine; 5% Pd(II)/C(eggshell) / ethanol; tetrahydrofuran / 24 h / 35 °C / 4500.45 - 5250.53 Torr
View Scheme
6-allyloxy-indan-1-one

6-allyloxy-indan-1-one

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N,N-dimethyl-aniline / Inert atmosphere; Reflux
1.2: 25 °C
2.1: ozone / dichloromethane / -78 - 20 °C / Inert atmosphere
2.2: 20 °C
3.1: toluene-4-sulfonic acid / toluene / 0.75 h / Reflux
4.1: hydrogen / triethylamine; 5% Pd(II)/C(eggshell) / ethanol; tetrahydrofuran / 24 h / 35 °C / 4500.45 - 5250.53 Torr
View Scheme
6-hydroxy-7-allyl-indan-1-one

6-hydroxy-7-allyl-indan-1-one

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ozone / dichloromethane / -78 - 20 °C / Inert atmosphere
1.2: 20 °C
2.1: toluene-4-sulfonic acid / toluene / 0.75 h / Reflux
3.1: hydrogen / triethylamine; 5% Pd(II)/C(eggshell) / ethanol; tetrahydrofuran / 24 h / 35 °C / 4500.45 - 5250.53 Torr
View Scheme
2-methoxy-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one
1290145-09-3

2-methoxy-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / toluene / 0.75 h / Reflux
2: hydrogen / triethylamine; 5% Pd(II)/C(eggshell) / ethanol; tetrahydrofuran / 24 h / 35 °C / 4500.45 - 5250.53 Torr
View Scheme
3-(2,3-dihydro-1-benzofuran-5-yl)prop-2-enoic acid
198707-57-2

3-(2,3-dihydro-1-benzofuran-5-yl)prop-2-enoic acid

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / 0.67 h / 26 - 73 °C / Heating / reflux
2.1: hydrogen / nickel / methanol / 4 h / 50 °C
3.1: bromine; sodium acetate; acetic acid / 14 h / 20 - 28 °C
4.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C
4.2: 1 h / -5 - 5 °C
5.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydroxide; hydrogen; ammonium formate / palladium 10% on activated carbon / water / 5 - 6 h / 20 °C
2.1: bromine; sodium acetate; acetic acid / 2 - 3 h / 0 - 45 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / 1 - 2 h / 20 °C
3.2: 1 - 2 h / 0 - 5 °C
4.1: hydrogen; sodium acetate; acetic acid / palladium 10% on activated carbon / 1471.14 - 2206.72 Torr
View Scheme
ethyl 3-(2,3-dihydrobenzofuran-5-yl)acrylate
217483-05-1

ethyl 3-(2,3-dihydrobenzofuran-5-yl)acrylate

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogen / nickel / methanol / 4 h / 50 °C
2.1: bromine; sodium acetate; acetic acid / 14 h / 20 - 28 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-benzene / 2 h / 28 - 60 °C
3.2: 1 h / -5 - 5 °C
4.1: hydrogen; sodium acetate / raney chloride / methanol / 50 °C
View Scheme
3-(2,3-dihydro-1-benzofuran-5-yl)propanoic acid
215057-28-6

3-(2,3-dihydro-1-benzofuran-5-yl)propanoic acid

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: bromine; sodium acetate; acetic acid / 2 - 3 h / 0 - 45 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / 1 - 2 h / 20 °C
2.2: 1 - 2 h / 0 - 5 °C
3.1: hydrogen; sodium acetate; acetic acid / palladium 10% on activated carbon / 1471.14 - 2206.72 Torr
View Scheme
2,3-dihydro-1-benzofuran-4-carbaldehyde
209256-42-8

2,3-dihydro-1-benzofuran-4-carbaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 6.5 h / -10 - 20 °C
2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
3: copper(II) bis(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 16 h / 10 - 20 °C
View Scheme
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-ol
1092507-07-7

2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran; methanol at 0 - 20℃; for 6h;100%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(4-chlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(4-chlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.366667h; Green chemistry;98%
2-chloro-6-fluorobenzaldehyde
387-45-1

2-chloro-6-fluorobenzaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(2-chloro-6-fluorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(2-chloro-6-fluorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.166667h; Green chemistry;98%
With sodium hydroxide In water
2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(2-chlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(2-chlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.333333h; Green chemistry;97%
With sodium hydroxide In water
2,3-dichlorobenzylaldehyde
6334-18-5

2,3-dichlorobenzylaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(2,3-dichlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(2,3-dichlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.483333h; Green chemistry;96%
3,4-dichlorobenzaldehyde
6287-38-3

3,4-dichlorobenzaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(3,4-dichlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(3,4-dichlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.6h; Green chemistry;96%
methylbenzenesulfonylmethylisonitrile

methylbenzenesulfonylmethylisonitrile

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-carbonitrile

2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-carbonitrile

Conditions
ConditionsYield
With potassium tert-butylate In 1,2-dimethoxyethane; ethanol at 0 - 60℃; for 18h;95%
1-naphthaldehyde
66-77-3

1-naphthaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(naphthalen-1-ylmethylene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(naphthalen-1-ylmethylene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.516667h; Green chemistry;95%
2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(2,4-dichlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(2,4-dichlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.583333h; Green chemistry;95%
benzaldehyde
100-52-7

benzaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-benzylidene-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-benzylidene-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.5h; Reagent/catalyst; Green chemistry;94%
With sodium hydroxide In water
2,6-dichlorobenzaldehyde
83-38-5

2,6-dichlorobenzaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(2,6-dichlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(2,6-dichlorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.583333h; Green chemistry;94%
With sodium hydroxide In water
cyanoacetic acid
372-09-8

cyanoacetic acid

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile
221530-44-5

2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile

Conditions
ConditionsYield
With piperidine at 100 - 110℃;93%
3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(3,4-dimethoxybenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(3,4-dimethoxybenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.666667h; Green chemistry;93%
(4-isopropylbenzaldehyde)
122-03-2

(4-isopropylbenzaldehyde)

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(4-isopropylbenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(4-isopropylbenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.5h; Green chemistry;91%
Cyclopropanecarboxaldehyde
1489-69-6

Cyclopropanecarboxaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(cyclopropylmethylene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(cyclopropylmethylene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.416667h; Green chemistry;90%
malononitrile
109-77-3

malononitrile

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

C14H10N2O

C14H10N2O

Conditions
ConditionsYield
With ammonium acetate; acetic acid In toluene Reagent/catalyst; Solvent;89.8%
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile
221530-44-5

2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile

Conditions
ConditionsYield
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.5h; Horner-Wadsworth-Emmons olefination;
Stage #2: 1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one In tetrahydrofuran; mineral oil at 40℃; for 1h; Horner-Wadsworth-Emmons olefination;
89%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium methylate In tetrahydrofuran at 20℃; for 1h;
Stage #2: 1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one In tetrahydrofuran at 20℃; for 2.25h;
80%
Stage #1: diethyl 1-cyanomethylphosphonate With sodium hydride In tetrahydrofuran at 25℃; for 1h; Large scale;
Stage #2: 1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one In tetrahydrofuran; water for 3.5h; Large scale;
5.1 kg
In methanol at 20℃; for 0.25h; Alkaline conditions;
With sodium methylate at 5 - 25℃;
diethyl 1-cyanomethylphosphonate
2537-48-6

diethyl 1-cyanomethylphosphonate

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)acetonitrile
196597-79-2

(E)-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)acetonitrile

Conditions
ConditionsYield
With sodium methylate In methanol; water; toluene88%
With sodium methylate In methanol; toluene at 20℃; Wittig Reaction;88%
With sodium methylate In methanol; toluene at 0℃; for 5h;84.4%
p-trifluoromethoxybenzaldehyde
659-28-9

p-trifluoromethoxybenzaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(4-[trifluoromethoxy]benzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(4-[trifluoromethoxy]benzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.333333h; Green chemistry;86%
3-Cyanobenzaldehyde
24964-64-5

3-Cyanobenzaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-3-((8-oxo-1,2,6,8-tetrahydro-7H-indeno[5,4-b]furan-7-ylidene)methyl)benzonitrile

(E)-3-((8-oxo-1,2,6,8-tetrahydro-7H-indeno[5,4-b]furan-7-ylidene)methyl)benzonitrile

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.666667h; Green chemistry;85%
4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-(4-[trifluoromethyl]benzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(4-[trifluoromethyl]benzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.383333h; Green chemistry;83%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

ethyl (2)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylideneacetate
1093972-05-4

ethyl (2)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylideneacetate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In toluene at 0 - 5℃; for 2h;
Stage #2: 1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one In toluene at 90 - 100℃; for 15 - 18h;
80%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In toluene; mineral oil at 0 - 20℃; Inert atmosphere;
Stage #2: 1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one In toluene; mineral oil at 90 - 100℃; Inert atmosphere;
[bromo(difluoro)methyl](trimethyl)silane
115262-01-6

[bromo(difluoro)methyl](trimethyl)silane

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

8-fluoro-1,2-dihydronaphtho[2,1-b]furan-9-ol

8-fluoro-1,2-dihydronaphtho[2,1-b]furan-9-ol

Conditions
ConditionsYield
Stage #1: [bromo(difluoro)methyl]-trimethyl-silane; 1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one With tetrabutylammomium bromide In toluene at 110℃; for 7h; Sealed tube;
Stage #2: With tetrabutyl ammonium fluoride In toluene at 20℃; for 2h;
80%
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

(E)-7-(3-fluorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-(3-fluorobenzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.433333h; Green chemistry;80%
2-chloro-3-quinoline carboxaldehyde
73568-25-9

2-chloro-3-quinoline carboxaldehyde

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

(E)-7-([2-chloroquinolin-3-yl]methylene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

(E)-7-([2-chloroquinolin-3-yl]methylene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 0.3h; Green chemistry;75%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
196597-78-1

1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

ethyl (Z)-2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetate

ethyl (Z)-2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In toluene at 20℃; for 2h; Cooling with ice;
Stage #2: 1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one In toluene at 90℃; Cooling with ice;
74%

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