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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(R)-2-Amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(R)-2-Amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99

(R)-2-Amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2R)-2-Amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C11H16N2O2 R)-2-amino-N-benzyl-3-methoxypropanamide 196601-69-1

Cas:196601-69-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 196601-69-1 with best quality

Cas:196601-69-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

196601-69-1(R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(R)-2-amino-N-benzyl-3-methoxypropanamide 196601-69-1

Cas:196601-69-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 196601-69-1 (R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:As

(R)-2-Amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:196601-69-1

196601-69-1

Cas:196601-69-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(R)-2-AMINO-N-BENZYL-3-METHOXYPROPANAMIDE

Cas:196601-69-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

ProName: (R)-2-Amino-N-benzyl-3-methoxypropanam... CasNo: 196601-69-1 Molecular Formula: C11H16N2O2 Appearance: detailed see specifications Application: It is an important raw material and in... DeliveryTime: prompt PackAge: according to the

(R)-2-Amino-N-benzyl-3-methoxypropanamide CAS NO.196601-69-1

Cas:196601-69-1

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

(R)-2-Amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

(R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (R)-2-Amino-N-Benzyl-3-Methoxypropionamide CAS No.:196601-69-1 Molecule Formula:C11H16N2O2 Molecule Weight:208.25 Purity: 99% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TES

High Quality (R)-2-Amino-N-Benzyl-3-Methoxypropionamide in stock

Cas:196601-69-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

(R)-2-Amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:0

Negotiable

Type:Other

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

(R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

Product Name: (R)-2-amino-N-benzyl-3-methoxypropanamide Synonyms: (R)-2-amino-N-benzyl-3-methoxypropanamide;2(R)-Amino-N-benzyl-3-methoxypropionamide…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

(R)-2-Amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:0

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

(R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Hangzhou Dingyan Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best qualit

(R)-2-amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(R)-2-Amino-N-benzyl-3-methoxypropionamide

Cas:196601-69-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

(R)-2-Amino-N-Benzyl-3-Methoxypropanamide

Cas:196601-69-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

(R)-2-Amino-n-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

(R)-2-Amino-N-benzyl-3-methoxypropanamide

Cas:196601-69-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(R)-N-benzyl 2-N-(benzylcarboxycarbonyl)amino-3-methoxypropionamide
196601-68-0

(R)-N-benzyl 2-N-(benzylcarboxycarbonyl)amino-3-methoxypropionamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol for 3h; Ambient temperature;100%
With hydrogen; palladium on activated charcoal In methanol at 20℃; under 760 Torr; for 4h;96%
With palladium 10% on activated carbon; hydrogen at 20℃;95%
tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
With hydrogenchloride; water In dichloromethane at 0 - 30℃; for 2h;100%
With hydrogenchloride; water In dichloromethane at 0 - 30℃; for 2h;100%
With hydrogenchloride In dichloromethane; water at 0 - 10℃; for 1h;100%
C17H19N3O4

C17H19N3O4

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Stage #1: C17H19N3O4 With 5%-palladium/activated carbon; hydrogen In ethyl acetate at 20℃; under 760.051 Torr; for 4h;
Stage #2: With [bis(acetoxy)iodo]benzene In acetonitrile at 0℃; for 0.5h;
Stage #3: With sulfuric acid at 20℃; for 1h; enantioselective reaction;
95%
tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate
1253790-58-7

tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate

dimethyl sulfate
77-78-1

dimethyl sulfate

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Stage #1: tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate; dimethyl sulfate With water; sodium hydroxide; tetrabutylammomium bromide In dichloromethane at -10 - -5℃;
Stage #2: With hydrogenchloride In dichloromethane; water at 25 - 30℃; for 2h;
90.71%
N-Benzyl-2-Amino-3-Methoxypropionamide
262845-82-9

N-Benzyl-2-Amino-3-Methoxypropionamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
With L-Tartaric acid; phosphoric acid; benzaldehyde In methanol at 50℃; pH=6;72%
benzylamine
100-46-9

benzylamine

N-acetyl-N'-(3,4-dichlorophenylhaloacetyl)-hydrazide

N-acetyl-N'-(3,4-dichlorophenylhaloacetyl)-hydrazide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 4-methylmorpholine / tetrahydrofuran / 0.03 h / -78 °C
1.2: isobutyl chloroformate / tetrahydrofuran / 0.03 h
1.3: 65 percent / tetrahydrofuran / -78 - 20 °C
2.1: 90 percent / Ag2O / acetonitrile / 20 °C
3.1: 96 percent / H2 / Pd/C / methanol / 4 h / 20 °C / 760 Torr
View Scheme
(R)-N-benzyl 2-N-(benzyloxycarbonyl)amino-3-hydroxypropionamide
219835-31-1

(R)-N-benzyl 2-N-(benzyloxycarbonyl)amino-3-hydroxypropionamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / Ag2O / acetonitrile / 20 °C
2: 96 percent / H2 / Pd/C / methanol / 4 h / 20 °C / 760 Torr
View Scheme
Multi-step reaction with 2 steps
1: 84 percent / Ag2O / acetonitrile / 72 h / Ambient temperature
2: 100 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: silver(l) oxide / acetonitrile / 120 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide; tetrabutylammomium bromide / water; tert-butyl methyl ether / 12 h / -10 - 5 °C
2.1: hydrogenchloride; water / 0.75 h / 40 - 45 °C
2.2: 0 - 5 °C
View Scheme
benzylamine
100-46-9

benzylamine

chloride of/the/ 2-nitro-toluene-sulfonic acid-(4)

chloride of/the/ 2-nitro-toluene-sulfonic acid-(4)

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 1 h / Ambient temperature
2: 84 percent / Ag2O / acetonitrile / 72 h / Ambient temperature
3: 100 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature
View Scheme
N-benzyl-O-methyl-N2-trityl-D-serinamide
1159573-88-2

N-benzyl-O-methyl-N2-trityl-D-serinamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Stage #1: N-benzyl-O-methyl-N2-trityl-D-serinamide With hydrogenchloride In dichloromethane; water at 20℃; for 0.5h;
Stage #2: With ammonia In water
Stage #1: N-benzyl-O-methyl-N2-trityl-D-serinamide With acetic acid In ethanol at 20℃; for 0.5h;
Stage #2: With ammonia In water Product distribution / selectivity;
With hydrogenchloride In dichloromethane; water at 20℃; for 0.5h; Product distribution / selectivity;
C20H24N2O4

C20H24N2O4

(R)-N-benzyl 2-N-(benzylcarboxycarbonyl)amino-3-methoxypropionamide
196601-68-0

(R)-N-benzyl 2-N-(benzylcarboxycarbonyl)amino-3-methoxypropionamide

A

C12H18N2O2

C12H18N2O2

B

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 30 - 35℃; under 3750.38 - 4500.45 Torr; for 1h;
(R)-N-benzyl-2-amino-3-methoxypropionamide oxalate

(R)-N-benzyl-2-amino-3-methoxypropionamide oxalate

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
With sodium hydroxide In water
benzylamine
100-46-9

benzylamine

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / -5 °C
1.2: -5 - 0 °C
2.1: potassium hydroxide / dichloromethane / 5 °C
2.2: 5 °C
3.1: hydrogenchloride / dichloromethane; water / 25 - 30 °C
3.2: 25 - 30 °C / pH 10 - 11
View Scheme
Multi-step reaction with 3 steps
1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 4-methyl-morpholine / ethyl acetate / 3.5 h / 4 - 25 °C / Inert atmosphere
2.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 4 - 25 °C / Inert atmosphere
3.1: hydrogenchloride; water / dichloromethane / 3 h / 25 °C
3.2: 4 - 8 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 4-methyl-morpholine / ethyl acetate / 3.5 h / 4 - 25 °C / Cooling with ice; Inert atmosphere
2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane; water / 4 - 25 °C / Cooling with ice; Inert atmosphere
3.1: hydrogenchloride; water / dichloromethane / 3 h / 25 °C
3.2: 4 - 8 °C
View Scheme
tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate
1253790-58-7

tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium hydroxide / dichloromethane / 5 °C
1.2: 5 °C
2.1: hydrogenchloride / dichloromethane; water / 25 - 30 °C
2.2: 25 - 30 °C / pH 10 - 11
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 4 - 25 °C / Inert atmosphere
2.1: hydrogenchloride; water / dichloromethane / 3 h / 25 °C
2.2: 4 - 8 °C
View Scheme
Multi-step reaction with 2 steps
1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane; water / 4 - 25 °C / Cooling with ice; Inert atmosphere
2.1: hydrogenchloride; water / dichloromethane / 3 h / 25 °C
2.2: 4 - 8 °C
View Scheme
(R)-N-benzyl-2-(dibenzylamino)-3-methoxypropanamide
1346691-15-3

(R)-N-benzyl-2-(dibenzylamino)-3-methoxypropanamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
With hydrogen; palladium(II) hydroxide In methanol at 25 - 30℃; under 3677.86 Torr; for 8h; Inert atmosphere;
With hydrogen; palladium(II) hydroxide In methanol at 25 - 30℃; under 3750.38 Torr; for 8h; Inert atmosphere;
(2R)-2-amino-3-hydroxy-N-(phenylmethyl)propanamide
175481-39-7

(2R)-2-amino-3-hydroxy-N-(phenylmethyl)propanamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: ethyl acetate / 1 h / 25 - 30 °C
1.2: 1 h / 25 - 30 °C
2.1: sodium hydroxide; water / tetrabutylammomium bromide / dichloromethane / -10 - -5 °C
2.2: 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran
2.1: potassium hydroxide; tetrabutylammomium bromide / ethyl acetate
3.1: hydrogenchloride / water / Reflux
3.2: pH 8 - 9
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / tetrahydrofuran
2: tetrabutylammomium bromide; potassium hydroxide / ethyl acetate
3: hydrogenchloride; water / Reflux
View Scheme
(2R)-2-azido-N-benzyl-3-hydroxypropanamide
1357171-71-1

(2R)-2-azido-N-benzyl-3-hydroxypropanamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 1 h / 25 - 30 °C / 2795.17 Torr / Autoclave
2.1: ethyl acetate / 1 h / 25 - 30 °C
2.2: 1 h / 25 - 30 °C
3.1: sodium hydroxide; water / tetrabutylammomium bromide / dichloromethane / -10 - -5 °C
3.2: 2 h / 25 - 30 °C
View Scheme
(2S)-N-benzyl-2-bromo-3-hydroxypropanamide
1357171-70-0

(2S)-N-benzyl-2-bromo-3-hydroxypropanamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium azide / N,N-dimethyl-formamide / 50 - 55 °C
2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 1 h / 25 - 30 °C / 2795.17 Torr / Autoclave
3.1: ethyl acetate / 1 h / 25 - 30 °C
3.2: 1 h / 25 - 30 °C
4.1: sodium hydroxide; water / tetrabutylammomium bromide / dichloromethane / -10 - -5 °C
4.2: 2 h / 25 - 30 °C
View Scheme
(R)-N-benzyl-2-(ethoxycarbonylamino)-3-hydroxypropionamide
1320360-91-5

(R)-N-benzyl-2-(ethoxycarbonylamino)-3-hydroxypropionamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium hydroxide; tetrabutylammomium bromide / ethyl acetate
2.1: hydrogenchloride / water / Reflux
2.2: pH 8 - 9
View Scheme
Multi-step reaction with 2 steps
1: tetrabutylammomium bromide; potassium hydroxide / ethyl acetate
2: hydrogenchloride; water / Reflux
View Scheme
(R)-N-benzyl-2-(ethoxycarbonylamino)-3-methoxypropionamide
1320360-92-6

(R)-N-benzyl-2-(ethoxycarbonylamino)-3-methoxypropionamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Stage #1: (R)-N-benzyl-2-(ethoxycarbonylamino)-3-methoxypropionamide With hydrogenchloride In water Reflux;
Stage #2: With sodium hydroxide In water pH=8 - 9;
With hydrogenchloride; water Reflux;
(2R)-2-amino-N-benzyl-3-hydroxypropanamide hydrochloride
1322062-75-8

(2R)-2-amino-N-benzyl-3-hydroxypropanamide hydrochloride

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / water / 20 - 25 °C / pH 8 - 9
2: triethylamine / tetrahydrofuran
3: tetrabutylammomium bromide; potassium hydroxide / ethyl acetate
4: hydrogenchloride; water / Reflux
View Scheme
N-benzyl-2-amino-3-methoxypropanamide N-formyl-L-leucine salt

N-benzyl-2-amino-3-methoxypropanamide N-formyl-L-leucine salt

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
With alkaline salt solution In dichloromethane; water1.59 g
(R)-tert-butyl (1-(benzylamino)-3-methoxy-1-oxopropan-2-yl)-N-(hydroxymethyl)carbamate

(R)-tert-butyl (1-(benzylamino)-3-methoxy-1-oxopropan-2-yl)-N-(hydroxymethyl)carbamate

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tert-butyl methyl ether / 60 - 65 °C
2: hydrogenchloride; water / dichloromethane / 2 h / 0 - 30 °C
View Scheme
(R)-N-benzyl-2-(isoindolin-2-yl)-3-methoxypropanamide

(R)-N-benzyl-2-(isoindolin-2-yl)-3-methoxypropanamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
With hydrazine hydrate In isopropyl alcohol at 0 - 25℃; for 2h; Inert atmosphere;
With hydrazine hydrate In isopropyl alcohol at 0 - 25℃; for 2h; Inert atmosphere;
C10H12ClNO2

C10H12ClNO2

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: methanol / 3 h / 0 - 20 °C / Inert atmosphere
2: triethylamine; dmap / dichloromethane / 12 h / 20 °C / Inert atmosphere; Cooling with ice
3: sodium azide / water; N,N-dimethyl-formamide / 6 h / 70 °C / Inert atmosphere
4: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 20 °C / Autoclave
View Scheme
(S)-N-benzyl-2-hydroxy-3-methoxypropanamide
1567820-75-0

(S)-N-benzyl-2-hydroxy-3-methoxypropanamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; dmap / dichloromethane / 12 h / 20 °C / Inert atmosphere; Cooling with ice
2: sodium azide / water; N,N-dimethyl-formamide / 6 h / 70 °C / Inert atmosphere
3: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 20 °C / Autoclave
View Scheme
(S)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl 4-toluenesulfonate
1567820-77-2

(S)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl 4-toluenesulfonate

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium azide / water; N,N-dimethyl-formamide / 6 h / 70 °C / Inert atmosphere
2: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 20 °C / Autoclave
View Scheme
(R)-2-azido-N-benzyl-3-methoxypropanamide

(R)-2-azido-N-benzyl-3-methoxypropanamide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In methanol at 20℃; for 3h; Autoclave;
D-o-methylserine
86118-11-8

D-o-methylserine

benzylamine
100-46-9

benzylamine

A

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

B

(S)-N-benzyl 2-amino-3-methoxypropionamide
474534-78-6

(S)-N-benzyl 2-amino-3-methoxypropionamide

Conditions
ConditionsYield
With tris(2,2,2-trifluoroethyl) borate at 125℃; under 760.051 Torr; for 4h;A n/a
B n/a
acetic anhydride
108-24-7

acetic anhydride

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

lacosamide

lacosamide

Conditions
ConditionsYield
With pyridine; dmap In tetrahydrofuran for 1h; Ambient temperature;90%
With pyridine In tetrahydrofuran at 20℃; for 1h; enantioselective reaction;88%
at 10 - 25℃;81.8%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

N-benzyl-2-(2-bromo-acetylamino)-3-methoxy-propionamide

N-benzyl-2-(2-bromo-acetylamino)-3-methoxy-propionamide

Conditions
ConditionsYield
With sodium hydrogencarbonate; sodium carbonate In dichloromethane at 5 - 10℃;78%
Isopropenyl acetate
108-22-5

Isopropenyl acetate

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

lacosamide

lacosamide

Conditions
ConditionsYield
In Isopropyl acetate at 23 - 75℃;68.9%
acetyl chloride
75-36-5

acetyl chloride

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

lacosamide

lacosamide

Conditions
ConditionsYield
With triethylamine at 10 - 25℃;62.4%
With triethylamine In dichloromethane at 10 - 25℃;3.12 g
With sodium carbonate In toluene at 0 - 5℃; for 1h; Inert atmosphere;935 mg
With sodium carbonate In toluene at 0 - 5℃; for 1h;935 mg
With triethylamine at 0 - 20℃; for 1.58333h; Inert atmosphere;108 mg
acetaldehyde
75-07-0

acetaldehyde

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

N-benzyl-2-ethylamino-3-methoxy-propionamide

N-benzyl-2-ethylamino-3-methoxy-propionamide

Conditions
ConditionsYield
With sodium cyanoborohydride In methanol at 20℃; for 0.166667h;51%
acetic anhydride
108-24-7

acetic anhydride

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

A

(2S)-2-(acetylamino)-N-benzyl-3-methoxypropanamide

(2S)-2-(acetylamino)-N-benzyl-3-methoxypropanamide

B

lacosamide

lacosamide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h;
C12H18N2O2

C12H18N2O2

acetic anhydride
108-24-7

acetic anhydride

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

A

C14H20N2O3

C14H20N2O3

B

lacosamide

lacosamide

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 20℃; for 1h;
oxalic acid
144-62-7

oxalic acid

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

(R)-N-benzyl-2-amino-3-methoxypropionamide oxalate

(R)-N-benzyl-2-amino-3-methoxypropionamide oxalate

Conditions
ConditionsYield
In isopropyl alcohol at 0 - 32℃; for 1.25h;
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