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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

Lacosamide[CAS:175481-36-4] (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate[CAS:880468-89-3] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture.

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate for Lacosamide

Cas:880468-89-3

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

(R)-tert-Butyl 1-(benzylaMino)-3-Methoxy-1-oxopropan-2-ylcarbaMate

Cas:880468-89-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamat

Cas:880468-89-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

tert-Butyl N-[(1R)-1-(benzylcarbamoyl)-2-methoxyethyl]-carbamate

Cas:880468-89-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/786.html Product Name (R)-tert-Buty

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:1 Gram

FOB Price: $63.0

Type:Lab/Research institutions

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Leader Biochemical Group

About Product Technical Details (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate Basic information Product Name: (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

China Largest factory Manufacturer Supply (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate CAS 880468-89-3

Cas:880468-89-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C16H24N2O4 (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate 880468-89-3

Cas:880468-89-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 880468-89-3 with best quality

Cas:880468-89-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: BOC-serine methyl ether benzylamine Synonyms: (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate CAS:880468-89-3 MF: C16H24N2O4 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package:

BOC-serine methyl ether benzylamine

Cas:880468-89-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

880468-89-3 (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Qingdao Beluga Import and Export Co., LTD

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate CAS:880468-89-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermed

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate CAS:880468-89-3

Cas:880468-89-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

(R)-tert-Butyl 1-(benzylaMino)-3-Methoxy-1-oxopropan-2-ylcarbaMate CAS NO.880468-89-3

Cas:880468-89-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:880468-89-3

Best price 880468-89-3

Cas:880468-89-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(R) -2-tert-butoxycarbonyl amino-N-benzyl-3-methoxypropylamide

Cas:880468-89-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(R)-TERT-BUTYL 1-(BENZYLAMINO)-3-METHOXY-1-OXOPROPAN-2-YLCARBAMATE

Cas:880468-89-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcar...

Cas:880468-89-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate CAS NO.880468-89-3

Cas:880468-89-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(R) -2-tert-butoxycarbonyl amino-N-benzyl-3-methoxypropylamide

Cas:880468-89-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate

Cas:880468-89-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Synthetic route

N-Boc-O-methyl-D-serine pivalic anhydride

N-Boc-O-methyl-D-serine pivalic anhydride

benzylamine
100-46-9

benzylamine

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
In dichloromethane at 0 - 5℃; for 0.5h;100%
tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate
1253790-58-7

tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate

dimethyl sulfate
77-78-1

dimethyl sulfate

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium hydroxide In water; toluene at 0 - 30℃; for 1.5h;96.28%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane; water at 4 - 25℃; Inert atmosphere;75.8%
Stage #1: tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate; dimethyl sulfate With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane; water at 4 - 25℃; Cooling with ice; Inert atmosphere;
Stage #2: With ammonium hydroxide In dichloromethane; water
75.8%
2,4-dioxo-3-azaspiro[5.5]undecan-3-yl N-(tert-butoxycarbonyl)-O-methyl-D-serinate

2,4-dioxo-3-azaspiro[5.5]undecan-3-yl N-(tert-butoxycarbonyl)-O-methyl-D-serinate

benzylamine
100-46-9

benzylamine

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
at 20℃; for 3h;90.4%
benzylamine
100-46-9

benzylamine

(R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid
86123-95-7

(R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
Stage #1: (R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: benzylamine In tetrahydrofuran at -78 - 20℃; for 1h;
90%
With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -78 - 30℃; for 1h; Inert atmosphere;90%
Stage #1: (R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid With 4-methyl-morpholine In tetrahydrofuran at -78℃; for 0.0833333h; Inert atmosphere;
Stage #2: benzylamine With isobutyl chloroformate In tetrahydrofuran at -78 - 20℃; for 1h; Inert atmosphere;
90%
tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate
1253790-58-7

tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate

trimethoxonium tetrafluoroborate
420-37-1

trimethoxonium tetrafluoroborate

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 20℃; for 16h; Inert atmosphere; Green chemistry;81%
tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate
1253790-58-7

tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate

methyl p-toluene sulfonate
80-48-8

methyl p-toluene sulfonate

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium hydroxide In toluene at -1 - 2℃; Solvent; Reagent/catalyst; Temperature;80%
With tetrabutylammomium bromide; potassium hydroxide In water; toluene at 20℃; for 3h; Reagent/catalyst;60.97g
With tetrabutylammomium bromide; sodium hydroxide In water at 20℃; for 3h;38.5 g
With tetrabutylammomium bromide; sodium hydroxide In water; toluene at 20℃; for 3h;38.5 g
benzylamine
100-46-9

benzylamine

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / -5 °C
1.2: -5 - 0 °C
2.1: potassium hydroxide / dichloromethane / 5 °C
2.2: 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: methyl chloroformate; 4-methyl-morpholine / dichloromethane / 0.5 h / 35 °C
1.2: 20 °C
2.1: sodium hydroxide; tetrabutylammomium bromide / toluene; water / 2 - 27 °C
View Scheme
Multi-step reaction with 2 steps
1.1: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane / 5 °C
1.2: 0 - 5 °C
2.1: potassium hydroxide / 5 °C
2.2: 5 °C
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 10 h / 20 - 25 °C
2.1: sodium hydroxide / water / 0.5 h / 0 - 5 °C
2.2: 14 h / 5 - 10 °C
2.3: 0 - 5 °C
3.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 0.25 h / -15 - -10 °C
3.2: 3 h / -15 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water
1.2: 16 h / 20 °C
1.3: pH 3.5 - 4
2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1 h / -20 - 20 °C
3.1: sodium hydroxide / tetrabutylammomium bromide / dichloromethane; water / 2 h / 5 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: dmap; sodium hydroxide / water; tert-butyl alcohol / 11 h / 20 °C
2.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.5 h / 0 - 5 °C
2.2: 20 °C
3.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / -10 - -5 °C
3.2: 20 °C
View Scheme
tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water / 0.5 h / 0 - 5 °C
1.2: 14 h / 5 - 10 °C
1.3: 0 - 5 °C
2.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 0.25 h / -15 - -10 °C
2.2: 3 h / -15 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / -5 °C
1.2: -5 - 0 °C
2.1: potassium hydroxide / dichloromethane / 5 °C
2.2: 5 °C
View Scheme
Multi-step reaction with 2 steps
1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1 h / -20 - 20 °C
2: sodium hydroxide / tetrabutylammomium bromide / dichloromethane; water / 2 h / 5 - 20 °C
View Scheme
tert-butyl [(2R)-1-hydroxy-3-methoxypropan-2-yl]carbamate

tert-butyl [(2R)-1-hydroxy-3-methoxypropan-2-yl]carbamate

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium chlorite; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 6 h / 35 °C / pH 6.7 / aq. phosphate buffer
2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -78 °C / Inert atmosphere
2.2: 1 h / -78 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / acetonitrile; aq. phosphate buffer / 7 h / 35 °C / pH 6.7
2: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / -78 - 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: potassium dihydrogenphosphate; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / acetonitrile / 3 h / 20 °C
2.1: 4-methyl-morpholine / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
benzylamine
100-46-9

benzylamine

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 4-methyl-morpholine / ethyl acetate / 3.5 h / 4 - 25 °C / Inert atmosphere
2: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 4 - 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 4-methyl-morpholine / ethyl acetate / 3.5 h / 4 - 25 °C / Cooling with ice; Inert atmosphere
2: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane; water / 4 - 25 °C / Cooling with ice; Inert atmosphere
View Scheme
(4R)-3-(tert-butyloxycarbonyl)-4-(methoxymethyl)-5-oxazolidinone

(4R)-3-(tert-butyloxycarbonyl)-4-(methoxymethyl)-5-oxazolidinone

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / tert-butyl methyl ether / 60 - 65 °C
2: tert-butyl methyl ether / 60 - 65 °C
View Scheme
(R)-tert-butyl (1-(benzylamino)-3-methoxy-1-oxopropan-2-yl)-N-(hydroxymethyl)carbamate

(R)-tert-butyl (1-(benzylamino)-3-methoxy-1-oxopropan-2-yl)-N-(hydroxymethyl)carbamate

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
In tert-butyl methyl ether at 60 - 65℃; Solvent; Temperature;9 g
(R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid
86123-95-7

(R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / toluene / 120 - 130 °C / Dean-Stark
2: triethylamine / tert-butyl methyl ether / 60 - 65 °C
3: tert-butyl methyl ether / 60 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1: 4-methyl-morpholine / dichloromethane / 1 h / 0 - 5 °C
2: dichloromethane / 0.5 h / 0 - 5 °C
View Scheme
tert-butyl (R)-4-(methoxymethyl)-2,2-dimethyloxazolidine-3-carboxylate
721928-19-4

tert-butyl (R)-4-(methoxymethyl)-2,2-dimethyloxazolidine-3-carboxylate

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: p-toluenesulfonic acid monohydrate / methanol / 5 h / 20 °C
2.1: potassium dihydrogenphosphate; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / acetonitrile / 3 h / 20 °C
3.1: 4-methyl-morpholine / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester
108149-63-9

4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
2.1: p-toluenesulfonic acid monohydrate / methanol / 5 h / 20 °C
3.1: potassium dihydrogenphosphate; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / acetonitrile / 3 h / 20 °C
4.1: 4-methyl-morpholine / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
4.2: 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
benzylamine
100-46-9

benzylamine

(R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid
86123-95-7

(R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid

A

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

B

tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate
1253790-58-7

tert-butyl-N-[(1R)-2-(benzylamino)-1-(hydroxymethyl)-2-oxo-ethyl]carbamate

C

benzylcarbamic acid isobutyl ester
69805-82-9

benzylcarbamic acid isobutyl ester

D

C16H24N2O4

C16H24N2O4

E

C19H23N3O3

C19H23N3O3

F

C17H26N2O4

C17H26N2O4

Conditions
ConditionsYield
Stage #1: (R)-2-((tert-butoxycarbonyl)amino)-3-methoxypropionic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -10 - 0℃; for 3.5h;
Stage #2: benzylamine In dichloromethane at -10 - 15℃; for 2h; Overall yield = 150.3 g;
A n/a
B n/a
C n/a
D n/a
E n/a
F n/a
tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

(R)-2-amino-N-benzyl-3-methoxypropanamide
196601-69-1

(R)-2-amino-N-benzyl-3-methoxypropanamide

Conditions
ConditionsYield
With hydrogenchloride; water In dichloromethane at 0 - 30℃; for 2h;100%
With hydrogenchloride; water In dichloromethane at 0 - 30℃; for 2h;100%
With hydrogenchloride In dichloromethane; water at 0 - 10℃; for 1h;100%
tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

trifluoroacetic acid
76-05-1

trifluoroacetic acid

(R)-2-amino-N-benzyl-3-methoxypropanamide trifluoroacetate

(R)-2-amino-N-benzyl-3-methoxypropanamide trifluoroacetate

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h;100%
tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate
880468-89-3

tert-butyl [(2R)-1-(benzylamino)-3-methoxy-1-oxopropan-2-yl]carbamate

(R)-2-amino-N-benzyl-3-methoxypropionamide hydrochloride
1322062-76-9

(R)-2-amino-N-benzyl-3-methoxypropionamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol at 50℃; for 2h;
With hydrogenchloride In dichloromethane; water for 1h;n/a

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