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Hangzhou Think Chemical Co. Ltd

Product: Pemetrexed Disodium Intermediate Name 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrol[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid Molecular Formula C15H14N4O3 Molecular Weight 298.30

Hebei Nengqian Chemical Import and Export Co., LTD

ProName: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pym... CasNo: 137281-39-1 Molecular Formula: C15H14N4O3 Appearance: detailed see specifications Application: It is an important raw material and in... DeliveryTime: prompt PackAge: according to the

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid CAS:137281-39-1 CAS NO.137281-39-1

Cas:137281-39-1

Min.Order:1 Kilogram

FOB Price: $20.0 / 80.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ---------------------------------------------------------------------------------------------

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Pemetrexed Intermediate Benzoic Acid supplier in China

Cas:137281-39-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermediate Transpo

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c

137281-39-1 Benzoic acid,4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-

Cas:137281-39-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience 2. Free samples will be provided,ensure specifications and quality are right for customer 3. Customers will receive the most professional techn

Large Stock 99.0% Pemetrexed Intermediate 137281-39-1 Producer

Cas:137281-39-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Hubei DiBo chemical co., LTD

Name:4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid CAS NO: 137281-39-1 Grade:Medical scientific research and export Molecular formula:C15H14N4O3 Molecular weight:298.2967 Product Quality 12 years of chemica

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/844.html Product Name 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrol[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrol[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

Cas:137281-39-1

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--137281-39-1 -- 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supp

TIANFUCHEM--137281-39-1 -- 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid in stock

Cas:137281-39-1

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 137281-39-1 with competitive price

Cas:137281-39-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Solid Storage:Store in sealed contai

Pemetrexed Disodium Intermediate CAS 137281-39-1 with Purity 99%

Cas:137281-39-1

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzoic acid,4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]- 137281-39-1

Cas:137281-39-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

137281-39-1 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid

Cas:137281-39-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Product Name: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid CAS: 137281-39-1 MF: C15H14N4O3 MW: 298.3 EINECS: 429-790-9 Mol File: 137281-39-1.mol 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]py

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid

Cas:137281-39-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

YH-908 is a kind of highly purified, remodeled and organically modified bentonite which the raw material is natural calcium bentonite. It is mainly used in low to medium polar solvents, such as paints, inks and other products. It has the following

High quality CAS 137281-39-1with best price

Cas:137281-39-1

Min.Order:2 Metric Ton

FOB Price: $1820.0 / 1970.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid CAS:137281-39-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chem

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid CAS:137281-39-1

Cas:137281-39-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

Cas:137281-39-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Pemetrexed acid manufacturer with low price

Cas:137281-39-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Lonwin Chemical Group Limited

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrim CAS: 137281-39-1 Specification Test Items Specifications Result Appearance White to off-white powder Off-white powder

Factory supply 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrim

Cas:137281-39-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzoic acid,4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-

Cas:137281-39-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-(2-(2-Amino-4,7-Dihydro-4-Oxo-1H-Pymol(2,3-D)Pyrimodin-5-Yl)Ethyl)

Cas:137281-39-1

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao

Benzoicacid 137281-39-1

Cas:137281-39-1

Min.Order:1 Kilogram

FOB Price: $16.0 / 20.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid

Cas:137281-39-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid

Cas:137281-39-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-(2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid

Cas:137281-39-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
With water; sodium hydroxide at 40℃; for 1h;100%
With sodium hydroxide In water at 40℃; for 1.5h; Large scale;91%
With ethanol at 40℃; for 3h; Molecular sieve; Industrial scale;85.1%
4-[3-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-4-nitrobutyl]benzoic acid ethyl ester
229470-22-8

4-[3-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-4-nitrobutyl]benzoic acid ethyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
With sodium hydroxide; sulfuric acid; acetic acid In water; ethyl acetate98%
Multistep reaction;57%
Stage #1: 4-[3-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-4-nitrobutyl]benzoic acid ethyl ester With sodium hydroxide at 20℃; for 2h;
Stage #2: With sulfuric acid at 0℃; for 3h; Nef reaction;
Stage #3: With sodium hydroxide at 20℃; for 1h; pH=7;
57%
4-(3-bromo-4-oxobutyl)benzoic acid methyl ester

4-(3-bromo-4-oxobutyl)benzoic acid methyl ester

2,6-diaminopyrimidin-4-ol
56-06-4

2,6-diaminopyrimidin-4-ol

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
With sodium acetate In methanol; water at 50 - 55℃; for 5h; Inert atmosphere;75%
N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-benzoyl]-L-glutamic acid disodium salt

N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-benzoyl]-L-glutamic acid disodium salt

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
With hydrogenchloride; water at 100℃; for 120h;37%
With hydrogenchloride; water at 100℃; for 120h;37%
4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester
146943-41-1

4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
With water; trifluoroacetic acid
ethyl 4-(3-oxopropyl)benzoate
151864-81-2

ethyl 4-(3-oxopropyl)benzoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 68 percent / aq. NaOH / ethanol / 48 h / 38 °C
2.1: 90 percent / CH3SO2Cl; Et3N / CH2Cl2 / 0 - 20 °C
3.1: 91 percent / H2O; ethyl acetate / 24 h / 50 °C
4.1: aq. NaOH / 2 h / 20 °C
4.2: aq. H2SO4 / 3 h / 0 °C
4.3: 57 percent / aq. NaOH / 1 h / 20 °C / pH 7
View Scheme
Multi-step reaction with 4 steps
1: 72 percent / NaOH / ethanol
2: 90 percent / CH3SO2Cl; Et3N
3: 91 percent / ethyl acetate; H2O / 24 h / 50 °C
4: 57 percent
View Scheme
4-(3-hydroxy-4-nitrobutyl)benzoic acid ethyl ester
259145-25-0

4-(3-hydroxy-4-nitrobutyl)benzoic acid ethyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 90 percent / CH3SO2Cl; Et3N / CH2Cl2 / 0 - 20 °C
2.1: 91 percent / H2O; ethyl acetate / 24 h / 50 °C
3.1: aq. NaOH / 2 h / 20 °C
3.2: aq. H2SO4 / 3 h / 0 °C
3.3: 57 percent / aq. NaOH / 1 h / 20 °C / pH 7
View Scheme
Multi-step reaction with 3 steps
1: 90 percent / CH3SO2Cl; Et3N
2: 91 percent / ethyl acetate; H2O / 24 h / 50 °C
3: 57 percent
View Scheme
4-(4-nitrobut-3-enyl)benzoic acid ethyl ester

4-(4-nitrobut-3-enyl)benzoic acid ethyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 91 percent / H2O; ethyl acetate / 24 h / 50 °C
2.1: aq. NaOH / 2 h / 20 °C
2.2: aq. H2SO4 / 3 h / 0 °C
2.3: 57 percent / aq. NaOH / 1 h / 20 °C / pH 7
View Scheme
4-iodobenzoic acid ethyl ester
51934-41-9

4-iodobenzoic acid ethyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 98 percent / Pd(OAc)2
2: 72 percent / NaOH / ethanol
3: 90 percent / CH3SO2Cl; Et3N
4: 91 percent / ethyl acetate; H2O / 24 h / 50 °C
5: 57 percent
View Scheme
Multi-step reaction with 4 steps
1: lithium chloride; lithium acetate; tetrabutyl-ammonium chloride; palladium diacetate / N,N-dimethyl-formamide / 3 h / 70 °C
2: 2,2-dimethyl-5,5-dibromo-1,3-dioxane-4,6-dione; hydrogenchloride / diethyl ether / 24 h / 20 °C
3: sodium acetate / water; methanol / 3 h / 45 °C
4: sodium hydroxide / methanol / 24 h / 40 - 50 °C / Inert atmosphere
View Scheme
4-((E)-4-Nitro-but-3-enyl)-benzoic acid ethyl ester
229470-21-7

4-((E)-4-Nitro-but-3-enyl)-benzoic acid ethyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / ethyl acetate; H2O / 24 h / 50 °C
2: 57 percent
View Scheme
4-(tert-butoxycarbonyl)benzaldehyde
65874-27-3

4-(tert-butoxycarbonyl)benzaldehyde

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 94 percent / toluene / 1 h / Heating
2: 100 percent / H2 / 10percent Pd/C / ethyl acetate; methanol / 4 h
3: 99 percent / LiBH4 / diethyl ether / 15 h / Ambient temperature
4: 87 percent / oxalyl chloride, DMSO / CH2Cl2 / 0.25 h / -60 °C
5: 1) t-BuOK / 1) THF, toluene, 10 min, 2) toluene, 0 deg C, 20 min
6: 1) CH2Cl2, molecular sieves 3A, UV, 0 - 5 deg C
7: 74 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
8: CF3COOH, H2O
View Scheme
tert-Butyl 4-(3-hydroxy-1-propyl)benzoate
126931-32-6

tert-Butyl 4-(3-hydroxy-1-propyl)benzoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 87 percent / oxalyl chloride, DMSO / CH2Cl2 / 0.25 h / -60 °C
2: 1) t-BuOK / 1) THF, toluene, 10 min, 2) toluene, 0 deg C, 20 min
3: 1) CH2Cl2, molecular sieves 3A, UV, 0 - 5 deg C
4: 74 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
5: CF3COOH, H2O
View Scheme
3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal
134372-99-9

3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1) t-BuOK / 1) THF, toluene, 10 min, 2) toluene, 0 deg C, 20 min
2: 1) CH2Cl2, molecular sieves 3A, UV, 0 - 5 deg C
3: 74 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
4: CF3COOH, H2O
View Scheme
tert-butyl 4-(4-methoxy-3-butenyl)benzoate
134373-00-5

tert-butyl 4-(4-methoxy-3-butenyl)benzoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1) CH2Cl2, molecular sieves 3A, UV, 0 - 5 deg C
2: 74 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
3: CF3COOH, H2O
View Scheme
methyl 3-<4-(tert-butoxycarbonyl)phenyl>propenoate
146943-27-3

methyl 3-<4-(tert-butoxycarbonyl)phenyl>propenoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 100 percent / H2 / 10percent Pd/C / ethyl acetate; methanol / 4 h
2: 99 percent / LiBH4 / diethyl ether / 15 h / Ambient temperature
3: 87 percent / oxalyl chloride, DMSO / CH2Cl2 / 0.25 h / -60 °C
4: 1) t-BuOK / 1) THF, toluene, 10 min, 2) toluene, 0 deg C, 20 min
5: 1) CH2Cl2, molecular sieves 3A, UV, 0 - 5 deg C
6: 74 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
7: CF3COOH, H2O
View Scheme
methyl 3-<4-(tert-butoxycarbonyl)phenyl>propanoate
126931-31-5

methyl 3-<4-(tert-butoxycarbonyl)phenyl>propanoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 99 percent / LiBH4 / diethyl ether / 15 h / Ambient temperature
2: 87 percent / oxalyl chloride, DMSO / CH2Cl2 / 0.25 h / -60 °C
3: 1) t-BuOK / 1) THF, toluene, 10 min, 2) toluene, 0 deg C, 20 min
4: 1) CH2Cl2, molecular sieves 3A, UV, 0 - 5 deg C
5: 74 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
6: CF3COOH, H2O
View Scheme
4-(4-Cyano-3-dimethoxymethyl-4-ethoxycarbonyl-butyl)-benzoic acid tert-butyl ester

4-(4-Cyano-3-dimethoxymethyl-4-ethoxycarbonyl-butyl)-benzoic acid tert-butyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
2: CF3COOH, H2O
View Scheme
4-(4-carbomethoxyphenyl)butanal
106200-41-3

4-(4-carbomethoxyphenyl)butanal

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 5,5-dibromobarbituric acid; hydrogen bromide; acetic acid / dichloromethane / 25 °C / Large scale
2: sodium acetate / water; acetonitrile / 3 h / 40 °C / Large scale
3: sodium hydroxide / water / 1.5 h / 40 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: hydrogen bromide; acetic acid; bromine / ethyl acetate / 1 h / 0 °C
2: sodium acetate / water; acetonitrile / 3.5 h / 40 °C
3: sodium hydroxide; water / 1 h / 40 °C
View Scheme
Multi-step reaction with 3 steps
1: bromine / acetonitrile / 2 h / 0 - 20 °C
2: sodium acetate
3: sodium hydroxide; water
View Scheme
Multi-step reaction with 3 steps
1: pyridinium hydrobromide perbromide / acetonitrile / 0.17 h / -5 - 5 °C
2: sodium acetate; sodium hydrogensulfite / water / 2 h / 40 °C
3: sodium hydroxide; water / 2 h / 40 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid; 5,5-dibromobarbituric acid; hydrogen bromide / dichloromethane / 16 h / 20 °C
2: sodium acetate / acetonitrile; water / 3 h / 40 °C
3: sodium hydroxide / 1.5 h / 40 °C
View Scheme
4-(3-bromo-4-oxobutyl)benzoic acid methyl ester

4-(3-bromo-4-oxobutyl)benzoic acid methyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate / water; acetonitrile / 3 h / 40 °C / Large scale
2: sodium hydroxide / water / 1.5 h / 40 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1.1: sodium acetate
2.1: sodium hydroxide
2.2: 0 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium acetate / water; acetonitrile / 3.5 h / 40 °C
2: sodium hydroxide; water / 1 h / 40 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium acetate
2: sodium hydroxide; water
View Scheme
Multi-step reaction with 2 steps
1: sodium acetate / acetonitrile; water / 3 h / 40 °C
2: sodium hydroxide / 1.5 h / 40 °C
View Scheme
4-(4-hydroxy-1-butynyl)benzoic acid methyl ester
123910-86-1

4-(4-hydroxy-1-butynyl)benzoic acid methyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen; 5%-palladium/activated carbon / dichloromethane / 3.5 h / 3345.86 Torr / Inert atmosphere; Autoclave; Large scale
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / -10 - 20 °C / pH 9.5 / Large scale
3: 5,5-dibromobarbituric acid; hydrogen bromide; acetic acid / dichloromethane / 25 °C / Large scale
4: sodium acetate / water; acetonitrile / 3 h / 40 °C / Large scale
5: sodium hydroxide / water / 1.5 h / 40 °C / Large scale
View Scheme
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 25 - 30 °C / 6464.52 Torr / Inert atmosphere
2: potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / water; dichloromethane / 0.5 h / 25 - 30 °C / Inert atmosphere
3: pyridinium hydrobromide perbromide / tert-butyl methyl ether / 8 h / 25 - 30 °C / Inert atmosphere
4: sodium acetate / water; methanol / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: palladium 10% on activated carbon; hydrogen / dichloromethane / 30 °C / 37503.8 Torr / Flow reactor
2: sodium acetate; pyridinium chlorochromate / dichloromethane / 5 h / 20 °C
3: acetic acid; 5,5-dibromobarbituric acid; hydrogen bromide / dichloromethane / 16 h / 20 °C
4: sodium acetate / acetonitrile; water / 3 h / 40 °C
5: sodium hydroxide / 1.5 h / 40 °C
View Scheme
4-methoxycarbonylphenyl bromide
619-42-1

4-methoxycarbonylphenyl bromide

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: palladium dichloride; triphenylphosphine; copper(l) iodide; diethylamine / ethyl acetate / 4 h / 50 °C / Large scale
2: hydrogen; 5%-palladium/activated carbon / dichloromethane / 3.5 h / 3345.86 Torr / Inert atmosphere; Autoclave; Large scale
3: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / -10 - 20 °C / pH 9.5 / Large scale
4: 5,5-dibromobarbituric acid; hydrogen bromide; acetic acid / dichloromethane / 25 °C / Large scale
5: sodium acetate / water; acetonitrile / 3 h / 40 °C / Large scale
6: sodium hydroxide / water / 1.5 h / 40 °C / Large scale
View Scheme
Multi-step reaction with 4 steps
1: lithium acetate; lithium chloride; tetrabutyl-ammonium chloride; palladium diacetate / N,N-dimethyl-formamide / 75 °C / Inert atmosphere
2: hydrogen bromide; acetic acid; bromine / ethyl acetate / 1 h / 0 °C
3: sodium acetate / water; acetonitrile / 3.5 h / 40 °C
4: sodium hydroxide; water / 1 h / 40 °C
View Scheme
Multi-step reaction with 5 steps
1: triethylamine; copper(l) iodide; triphenylphosphine; palladium dichloride / 3 h / 75 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 25 - 30 °C / 6464.52 Torr / Inert atmosphere
3: potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / water; dichloromethane / 0.5 h / 25 - 30 °C / Inert atmosphere
4: pyridinium hydrobromide perbromide / tert-butyl methyl ether / 8 h / 25 - 30 °C / Inert atmosphere
5: sodium acetate / water; methanol / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: lithium acetate; lithium chloride; tetrabutylammomium bromide; palladium diacetate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere
2: pyridinium hydrobromide perbromide / acetonitrile / 0.17 h / -5 - 5 °C
3: sodium acetate; sodium hydrogensulfite / water / 2 h / 40 °C
4: sodium hydroxide; water / 2 h / 40 °C
View Scheme
Multi-step reaction with 6 steps
1: triphenylphosphine; palladium dichloride; copper(l) iodide; diethylamine / ethyl acetate / 4 h / 50 °C
2: palladium 10% on activated carbon; hydrogen / dichloromethane / 30 °C / 37503.8 Torr / Flow reactor
3: sodium acetate; pyridinium chlorochromate / dichloromethane / 5 h / 20 °C
4: acetic acid; 5,5-dibromobarbituric acid; hydrogen bromide / dichloromethane / 16 h / 20 °C
5: sodium acetate / acetonitrile; water / 3 h / 40 °C
6: sodium hydroxide / 1.5 h / 40 °C
View Scheme
methyl 4-(4-hydroxybut-1-yl)benzoate
123910-88-3

methyl 4-(4-hydroxybut-1-yl)benzoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / -10 - 20 °C / pH 9.5 / Large scale
2: 5,5-dibromobarbituric acid; hydrogen bromide; acetic acid / dichloromethane / 25 °C / Large scale
3: sodium acetate / water; acetonitrile / 3 h / 40 °C / Large scale
4: sodium hydroxide / water / 1.5 h / 40 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / water; dichloromethane / 0.5 h / 25 - 30 °C / Inert atmosphere
2: pyridinium hydrobromide perbromide / tert-butyl methyl ether / 8 h / 25 - 30 °C / Inert atmosphere
3: sodium acetate / water; methanol / 5 h / 50 - 55 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: sodium acetate; pyridinium chlorochromate / dichloromethane / 5 h / 20 °C
2: acetic acid; 5,5-dibromobarbituric acid; hydrogen bromide / dichloromethane / 16 h / 20 °C
3: sodium acetate / acetonitrile; water / 3 h / 40 °C
4: sodium hydroxide / 1.5 h / 40 °C
View Scheme
4-(4-carboxymethoxyphenyl)butanal sodium bisulfite adduct

4-(4-carboxymethoxyphenyl)butanal sodium bisulfite adduct

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: chloro-trimethyl-silane; bromine
2.1: sodium acetate
3.1: sodium hydroxide
3.2: 0 °C
View Scheme
ethyl 4-(3-formylpropyl)benzoate
72313-37-2

ethyl 4-(3-formylpropyl)benzoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2,2-dimethyl-5,5-dibromo-1,3-dioxane-4,6-dione; hydrogenchloride / diethyl ether / 24 h / 20 °C
2: sodium acetate / water; methanol / 3 h / 45 °C
3: sodium hydroxide / methanol / 24 h / 40 - 50 °C / Inert atmosphere
View Scheme
ethyl 4-(3-bromo-4-oxobutyl)benzoate
927897-33-4

ethyl 4-(3-bromo-4-oxobutyl)benzoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate / water; methanol / 3 h / 45 °C
2: sodium hydroxide / methanol / 24 h / 40 - 50 °C / Inert atmosphere
View Scheme
ethyl 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl)benzoate
151864-75-4

ethyl 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl)benzoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol at 40 - 50℃; for 24h; Inert atmosphere;
methyl 4-iodobenzoate
619-44-3

methyl 4-iodobenzoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium diacetate; lithium chloride; lithium acetate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 10 h / 60 °C / Inert atmosphere
2: bromine / acetonitrile / 2 h / 0 - 20 °C
3: sodium acetate
4: sodium hydroxide; water
View Scheme
acetic anhydride
108-24-7

acetic anhydride

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-[2-(2-acetylamino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

4-[2-(2-acetylamino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

Conditions
ConditionsYield
With acetic acid at 50℃; for 1h; Temperature;97.1%
With acetic acid at 30 - 50℃; for 1h; Temperature;97.1%
benzyl chloride
100-44-7

benzyl chloride

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-[2-(2-benzylamino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

4-[2-(2-benzylamino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 30 - 60℃; for 1h; Temperature;96.9%
With triethylamine In N,N-dimethyl-formamide at 30 - 50℃; for 1h; Temperature;
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-[2-(2-(p-tolylsulfonyl)amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

4-[2-(2-(p-tolylsulfonyl)amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 0 - 5℃; for 1h;96.7%
With triethylamine In N,N-dimethyl-formamide at 0 - 30℃; for 1h;
trityl chloride
76-83-5

trityl chloride

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-[2-(2-triphenylmethylamino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

4-[2-(2-triphenylmethylamino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 30 - 35℃; for 1h;96.3%
With triethylamine In N,N-dimethyl-formamide at 30 - 35℃; for 1h;
diethyl-L-glutamate hydrochloride
1118-89-4

diethyl-L-glutamate hydrochloride

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester
146943-43-3

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester

Conditions
ConditionsYield
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; sodium hydroxide In ethanol; water at 40℃; for 3h;94.5%
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine at 20℃; Condensation;62%
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: diethyl-L-glutamate hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃; for 3.5h;
62%
With 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-methylmorpholine N-oxide In N,N-dimethyl-formamide at 25℃; for 1.5h; Large scale;
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 6h;
3,5-dimethylisoxazol-4-amine
31329-64-3

3,5-dimethylisoxazol-4-amine

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(3,5-dimethylisoxazol-4-yl)benzamide

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(3,5-dimethylisoxazol-4-yl)benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0.1℃; for 3.25h; Inert atmosphere;93%
4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester
146943-43-3

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester

C39H41N9O8

C39H41N9O8

Conditions
ConditionsYield
With triethylamine; 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 25 - 30℃; for 2h; Temperature; Reagent/catalyst; Solvent;92.6%
4-chlorophenylethylamine
156-41-2

4-chlorophenylethylamine

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(4-chlorophenethyl)benzamide

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(4-chlorophenethyl)benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0.1℃; for 3.25h; Inert atmosphere;92%
2-thiazolylamine
96-50-4

2-thiazolylamine

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(thiazol-2-yl)benzamide

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(thiazol-2-yl)benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0.1℃; for 3.25h; Inert atmosphere;91%
L-glutamic dimethyl ester hydrochloride
23150-65-4

L-glutamic dimethyl ester hydrochloride

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

dipotassium (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido) pentanedioate

dipotassium (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido) pentanedioate

Conditions
ConditionsYield
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 0 - 30℃; Inert atmosphere;
Stage #2: L-glutamic dimethyl ester hydrochloride In N,N-dimethyl-formamide at 0 - 5℃;
Stage #3: With potassium hydroxide In dichloromethane; water for 1.5h;
90.38%
1-(o-fluorophenyl)piperazine
1011-15-0

1-(o-fluorophenyl)piperazine

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

2-amino-5-(4-(4-(2-fluorophenyl)piperazine-1-carbonyl)phenethyl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

2-amino-5-(4-(4-(2-fluorophenyl)piperazine-1-carbonyl)phenethyl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0.1℃; for 3.25h; Inert atmosphere;90%
1-Methylhomopiperazine
4318-37-0

1-Methylhomopiperazine

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

2-amino-5-(4-(4-methyl-1,4-diazepane-1-carbonyl)phenethyl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

2-amino-5-(4-(4-methyl-1,4-diazepane-1-carbonyl)phenethyl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0.1℃; for 3.25h; Inert atmosphere;89%
2-(aminoethyl)pyridine
2706-56-1

2-(aminoethyl)pyridine

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(2-(pyridin-2-yl)ethyl)benzamide

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(2-(pyridin-2-yl)ethyl)benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0.1℃; for 3.25h; Inert atmosphere;88%
4-methyl-morpholine
109-02-4

4-methyl-morpholine

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

diethyl-L-glutamate hydrochloride
1118-89-4

diethyl-L-glutamate hydrochloride

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

A

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester
146943-43-3

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester

B

4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-morpholine

4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-morpholine

Conditions
ConditionsYield
Stage #1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid In N,N-dimethyl-formamide at 20℃; for 1h; Cooling with ice; Inert atmosphere;
Stage #2: diethyl-L-glutamate hydrochloride In N,N-dimethyl-formamide at 35℃; for 2h; Inert atmosphere;
A 85.5%
B 4%
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

(R)-2-aminoglutaric acid diethyl ester hydrochloride

(R)-2-aminoglutaric acid diethyl ester hydrochloride

C24H29N5O6*C7H8O3S

C24H29N5O6*C7H8O3S

Conditions
ConditionsYield
Stage #1: (R)-2-aminoglutaric acid diethyl ester hydrochloride With sodium hydrogencarbonate In water at 20℃; for 0.5h;
Stage #2: toluene-4-sulfonic acid; 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane at 0 - 50℃; for 3h;
85%
1-(2-aminoethyl)piperidine
27578-60-5

1-(2-aminoethyl)piperidine

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(2-(piperidin-1-yl)ethyl)benzamide

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(2-(piperidin-1-yl)ethyl)benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0.1℃; for 3.25h; Inert atmosphere;84%
L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-glutamic acid heptakis-t-butyl ester
118252-57-6

L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-glutamic acid heptakis-t-butyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

C73H112N10O21

C73H112N10O21

Conditions
ConditionsYield
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 10 - 20℃; for 0.5h; Large scale;
Stage #2: L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-glutamic acid heptakis-t-butyl ester In N,N-dimethyl-formamide at 20℃; for 20h; Large scale;
82.5%
L-glutamic dimethyl ester hydrochloride
23150-65-4

L-glutamic dimethyl ester hydrochloride

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic dimethyl ester
155405-81-5

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic dimethyl ester

Conditions
ConditionsYield
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;
Stage #2: L-glutamic dimethyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃;
80.4%
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 0 - 5℃; for 1.5h;
Stage #2: L-glutamic dimethyl ester hydrochloride In N,N-dimethyl-formamide at 0 - 30℃;
65.5%
(S)-1-(pyrrolidin-3-yl)piperidine
917560-78-2

(S)-1-(pyrrolidin-3-yl)piperidine

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

(S)-2-amino-5-(4-(3-(piperidin-1-yl)pyrrolidine-1-carbonyl)phenethyl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

(S)-2-amino-5-(4-(3-(piperidin-1-yl)pyrrolidine-1-carbonyl)phenethyl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0.1℃; for 3.25h; Inert atmosphere;78%
(S)-benzyl 5-acetoxy-4-aminopentanoate
1376616-07-7

(S)-benzyl 5-acetoxy-4-aminopentanoate

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

(S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate
1376616-08-8

(S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate

Conditions
ConditionsYield
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 3h;
Stage #2: (S)-benzyl 5-acetoxy-4-aminopentanoate With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃;
77%
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 3h;
Stage #2: (S)-benzyl 5-acetoxy-4-aminopentanoate With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃;
77%
[(1S)-1-cyclohexylethyl]amine
17430-98-7

[(1S)-1-cyclohexylethyl]amine

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

(S)-4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(1-cyclohexylethyl)benzamide

(S)-4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(1-cyclohexylethyl)benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0.1℃; for 3.25h; Inert atmosphere;72%
4-fluoro-2-phenethylamine
1583-88-6

4-fluoro-2-phenethylamine

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(4-fluorophenethyl)benzamide

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(4-fluorophenethyl)benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0.1℃; for 3.25h; Inert atmosphere;71%
amine SDC-TRAP-0004
1207601-67-9

amine SDC-TRAP-0004

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl)ethyl)-N-methylbenzamide

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl)ethyl)-N-methylbenzamide

Conditions
ConditionsYield
With 1,2-dichloro-ethane In N,N-dimethyl-formamide at 20℃; for 18h;70%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 18h;70%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 18h;70%
amine SDC-TRAP-0004
1207601-67-9

amine SDC-TRAP-0004

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl)ethyl)-N-methylbenzamide

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)-N-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl)ethyl)-N-methylbenzamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 18h;70%
diethyl-L-glutamate hydrochloride
1118-89-4

diethyl-L-glutamate hydrochloride

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester 4-methylbenzenesulfonic acid salt
165049-28-5

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester 4-methylbenzenesulfonic acid salt

Conditions
ConditionsYield
Stage #1: diethyl-L-glutamate hydrochloride; 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere; Industrial scale;
Stage #2: toluene-4-sulfonic acid In ethanol; N,N-dimethyl-formamide at 70℃; Temperature; Inert atmosphere; Industrial scale;
68.1%
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 50 - 60℃; for 2h;
Stage #2: diethyl-L-glutamate hydrochloride With potassium carbonate In water; N,N-dimethyl-formamide at 80℃; for 3.5h;
Stage #3: toluene-4-sulfonic acid In ethanol for 1h; Reflux;
55.4 g
diethyl-L-glutamate hydrochloride
1118-89-4

diethyl-L-glutamate hydrochloride

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

(2R)-2-[[4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid diethyl ester p-toluenesulfonate

(2R)-2-[[4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid diethyl ester p-toluenesulfonate

Conditions
ConditionsYield
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane; N,N-dimethyl-formamide at 38 - 40℃; for 2h;
Stage #2: diethyl-L-glutamate hydrochloride In dichloromethane; N,N-dimethyl-formamide for 2h;
Stage #3: toluene-4-sulfonic acid In ethanol for 2h; Reflux;
66%
C10H21NO4Si

C10H21NO4Si

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid
137281-39-1

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

C25H33N5O6Si

C25H33N5O6Si

Conditions
ConditionsYield
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: C10H21NO4Si In N,N-dimethyl-formamide at 20℃; for 3h;
64%

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