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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99.5% up by Entecavir powder Entecavir API 142217-69-4

Cas:142217-69-4

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Entecavir from Wuhan, Hubei, China. It is made obtainabl

Entecavir

Cas:142217-69-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Hubei Vanz Pharm Co.,Ltd

We are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical

CAS 142217-69-4 Entecavir

Cas:142217-69-4

Min.Order:1 Gram

FOB Price: $10.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Entecavir Manufacturer/High quality/Best price/In stock

Cas:142217-69-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Entecavir in stock

Cas:142217-69-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White to off-white powder Storage:-20°C Freezer Package:10g/b

Good quality Entecavir (monohydrate) CAS 142217-69-4 with favorable price

Cas:142217-69-4

Min.Order:10 Gram

FOB Price: $40.0 / 50.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Entecavir

Cas:142217-69-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Entecavir 142217-69-4 ISO Manufacturer

Cas:142217-69-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Anhui Dexinjia Biopharm Co., Ltd

As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,

Entecavir

Cas:142217-69-4

Min.Order:1 Gram

FOB Price: $12.0

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Entecavir

Cas:142217-69-4

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

Entecavir

Cas:142217-69-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Entecavir

Cas:142217-69-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

High Purity Organic Medical Entecavir Powder CAS 142217-69-4 Entecavir

Cas:142217-69-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 142217-69-4 with competitive price

Cas:142217-69-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 142217-69-4 Entecavir in stock

Cas:142217-69-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Entecavir/ LIDE PHARMA- Factory supply / Best price

Cas:142217-69-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Chemical Name: Entecavir Molecular Formula: C12H15N5O3 Formula Weight: 277.283 CAS No.:142217-69-4;1367369-76-3 White to Off-White/Yellow Crystalline Powder Purity:99.5% Single impurity:NMT0.1% Total impurity:NMT0.3% Ad

Entecavir monohydrate

Cas:142217-69-4

Min.Order:5 Gram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99%min Entecavir Manufacturer 142217-69-4 Antiviral Anti-infectives

Cas:142217-69-4

Min.Order:10 Gram

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Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Entecavir 142217-69-4

Cas:142217-69-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Manufacturers Supply High Quality 99% Entecavir Raw Powder with Best Price Entecavir powder

Cas:142217-69-4

Min.Order:10 Gram

FOB Price: $0.6

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Product Name: Entecavir CAS: 142217-69-4 MF: C12H15N5O3 MW: 277.28 EINECS: 604-279-5 Mol File: 142217-69-4.mol Entecavir Structure Entecavir Chemical Properties Melting point 249-252°C Boiling point 661.4±65.0 &

Entecavir

Cas:142217-69-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Factory offer Medicine grade Anti-HBV drugs Entecavir CAS No 142217-69-4 and Entecavir

Cas:142217-69-4

Min.Order:1 Kilogram

FOB Price: $135.0 / 150.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Entecavir CAS:142217-69-4 .Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Entecavir CAS:142217-69-4

Cas:142217-69-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Entecavir

Cas:142217-69-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Package:in aluminum bag and foil bag or as customers' require Application:142217-69-4 Transp

Entecavir

Cas:142217-69-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 142217-69-4 Entecavir

Cas:142217-69-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:142217-69-4

Cas:142217-69-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe

Entecavir CAS 142217-69-4

Cas:142217-69-4

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

entecavir

Cas:142217-69-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

99%min Appearance:A white to nearly white crystalline powder Storage:Room temperature Package:as required Application:used medicine Transportation:by sea by air express Port:China main port

Entecavir 99%min Pharmaceutical Nucleoside Antivirus products made in china

Cas:142217-69-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Synthetic route

((1 R,3S,5S)-5-acetoxy-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylenecyclopentyl)methyl acetate
1383812-22-3

((1 R,3S,5S)-5-acetoxy-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylenecyclopentyl)methyl acetate

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Stage #1: ((1 R,3S,5S)-5-acetoxy-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylenecyclopentyl)methyl acetate With sodium hydroxide at 80℃; for 2h;
Stage #2: With hydrogenchloride In water at 0℃; pH=7;
60%
(1S,3R)-3-(tert-butyldimethylsilyloxy)-1-(oxiran-2-yl)pent-4-yn-1-ol
1383811-98-0

(1S,3R)-3-(tert-butyldimethylsilyloxy)-1-(oxiran-2-yl)pent-4-yn-1-ol

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: chloro-trimethyl-silane; 2,4,6-trimethyl-pyridine; zinc / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
2.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
3.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
5.1: sodium hydroxide / 2 h / 80 °C
5.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 6 steps
1.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
2.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C
3.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
4.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
5.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
6.1: sodium hydroxide / 2 h / 80 °C
6.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 7 steps
1.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
2.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
3.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
4.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction
5.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
5.2: 4.17 h / -10 °C / Inert atmosphere
6.1: formic acid / 9 h / 50 °C / Inert atmosphere
7.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
7.2: pH 7 / Inert atmosphere
View Scheme
(3S,5R)-7-(trimethylsilyl)hept-1-en-6-yne-3,5-diol
1383811-86-6

(3S,5R)-7-(trimethylsilyl)hept-1-en-6-yne-3,5-diol

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 1H-imidazole / tetrahydrofuran / 0 - 15 °C / Inert atmosphere
2.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
4.1: chloro-trimethyl-silane; 2,4,6-trimethyl-pyridine; zinc / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
5.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
7.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
8.1: sodium hydroxide / 2 h / 80 °C
8.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 8 steps
1.1: 1H-imidazole / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
2.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
4.1: chloro-trimethyl-silane; 2,4,6-trimethyl-pyridine; zinc / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
5.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
7.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
8.1: sodium hydroxide / 2 h / 80 °C
8.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 9 steps
1.1: 1H-imidazole / tetrahydrofuran / 0 - 15 °C / Inert atmosphere
2.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
4.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
5.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C
6.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
7.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
8.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
9.1: sodium hydroxide / 2 h / 80 °C
9.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 9 steps
1.1: 1H-imidazole / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
2.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
4.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
5.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C
6.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
7.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
8.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
9.1: sodium hydroxide / 2 h / 80 °C
9.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 10 steps
1.1: 1H-imidazole / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
2.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
4.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
5.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
6.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
7.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction
8.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
8.2: 4.17 h / -10 °C / Inert atmosphere
9.1: formic acid / 9 h / 50 °C / Inert atmosphere
10.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
10.2: pH 7 / Inert atmosphere
View Scheme
(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(trimethylsilyl)hept-1-en-6-yn-3-ol
1383811-90-2

(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(trimethylsilyl)hept-1-en-6-yn-3-ol

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
3.1: chloro-trimethyl-silane; 2,4,6-trimethyl-pyridine; zinc / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
4.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
5.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
6.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
7.1: sodium hydroxide / 2 h / 80 °C
7.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 8 steps
1.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
3.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
4.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C
5.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
7.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
8.1: sodium hydroxide / 2 h / 80 °C
8.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 9 steps
1.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
3.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
4.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
5.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
6.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction
7.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
7.2: 4.17 h / -10 °C / Inert atmosphere
8.1: formic acid / 9 h / 50 °C / Inert atmosphere
9.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
9.2: pH 7 / Inert atmosphere
View Scheme
(3S,5R)-5-(tert-butyldimethylsilyloxy)hept-1-en-6-yn-3-ol
1383811-94-6

(3S,5R)-5-(tert-butyldimethylsilyloxy)hept-1-en-6-yn-3-ol

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
2.1: chloro-trimethyl-silane; 2,4,6-trimethyl-pyridine; zinc / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
4.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
5.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
6.1: sodium hydroxide / 2 h / 80 °C
6.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 7 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
2.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
3.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C
4.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
5.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
6.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
7.1: sodium hydroxide / 2 h / 80 °C
7.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 8 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
2.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
3.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
4.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
5.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction
6.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
6.2: 4.17 h / -10 °C / Inert atmosphere
7.1: formic acid / 9 h / 50 °C / Inert atmosphere
8.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
8.2: pH 7 / Inert atmosphere
View Scheme
(1S,3R)-3-(tert-butyldimethylsilyloxy)-1-(oxiran-2-yl)pent-4-ynyl acetate
1383812-02-9

(1S,3R)-3-(tert-butyldimethylsilyloxy)-1-(oxiran-2-yl)pent-4-ynyl acetate

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C
2.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
3.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
5.1: sodium hydroxide / 2 h / 80 °C
5.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 6 steps
1.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
2.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction
4.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
4.2: 4.17 h / -10 °C / Inert atmosphere
5.1: formic acid / 9 h / 50 °C / Inert atmosphere
6.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
6.2: pH 7 / Inert atmosphere
View Scheme
(1S,2R,4R)-4-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)-3-methylenecyclopentyl acetate
1383812-06-3

(1S,2R,4R)-4-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)-3-methylenecyclopentyl acetate

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
2.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
4.1: sodium hydroxide / 2 h / 80 °C
4.2: 0 °C / pH 7
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction
3.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
3.2: 4.17 h / -10 °C / Inert atmosphere
4.1: formic acid / 9 h / 50 °C / Inert atmosphere
5.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
5.2: pH 7 / Inert atmosphere
View Scheme
(1S,2R,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)-3-methylenecyclopentanol
701278-65-1

(1S,2R,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)-3-methylenecyclopentanol

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
2.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
4.1: sodium hydroxide / 2 h / 80 °C
4.2: 0 °C / pH 7
View Scheme
((1R,3R,5S)-5-acetoxy-3-(tert-butyldimethylsilyloxy)-2-methylenecyclopentyl)methyl acetate
1383812-10-9

((1R,3R,5S)-5-acetoxy-3-(tert-butyldimethylsilyloxy)-2-methylenecyclopentyl)methyl acetate

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
3.1: sodium hydroxide / 2 h / 80 °C
3.2: 0 °C / pH 7
View Scheme
((1R,3R,5S)-5-acetoxy-3-hydroxy-2-methylenecyclo-pentyl) methyl acetate

((1R,3R,5S)-5-acetoxy-3-hydroxy-2-methylenecyclo-pentyl) methyl acetate

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
2.1: sodium hydroxide / 2 h / 80 °C
2.2: 0 °C / pH 7
View Scheme
((1R,3R,5S)-5-acetoxy-3-(tert-butyldimethylsilyloxy)-2-methylenecyclopentyl)methyl 4-nitrobenzoate
1435752-36-5

((1R,3R,5S)-5-acetoxy-3-(tert-butyldimethylsilyloxy)-2-methylenecyclopentyl)methyl 4-nitrobenzoate

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction
2.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
2.2: 4.17 h / -10 °C / Inert atmosphere
3.1: formic acid / 9 h / 50 °C / Inert atmosphere
4.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
4.2: pH 7 / Inert atmosphere
View Scheme
((1R,3R,5S)-5-acetoxy-3-hydroxy-2-methylenecyclopentyl)methyl 4-nitrobenzoate
1435752-42-3

((1R,3R,5S)-5-acetoxy-3-hydroxy-2-methylenecyclopentyl)methyl 4-nitrobenzoate

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
1.2: 4.17 h / -10 °C / Inert atmosphere
2.1: formic acid / 9 h / 50 °C / Inert atmosphere
3.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
3.2: pH 7 / Inert atmosphere
View Scheme
((1R,3S,5S)-5-acetoxy-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylenecyclopentyl)methyl 4-nitrobenzoate
1435752-48-9

((1R,3S,5S)-5-acetoxy-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylenecyclopentyl)methyl 4-nitrobenzoate

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: formic acid / 9 h / 50 °C / Inert atmosphere
2.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
2.2: pH 7 / Inert atmosphere
View Scheme
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
1.2: 4.17 h / -10 °C / Inert atmosphere
2.1: formic acid / 9 h / 50 °C / Inert atmosphere
3.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
3.2: pH 7 / Inert atmosphere
View Scheme
((1R,3S,5S)-5-acetoxy-3-(2-amino-6-oxo-1H-purin-9(6H)-yl)-2-methylenecyclopentyl)methyl 4-nitrobenzoate
1435752-55-8

((1R,3S,5S)-5-acetoxy-3-(2-amino-6-oxo-1H-purin-9(6H)-yl)-2-methylenecyclopentyl)methyl 4-nitrobenzoate

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Stage #1: ((1R,3S,5S)-5-acetoxy-3-(2-amino-6-oxo-1H-purin-9(6H)-yl)-2-methylenecyclopentyl)methyl 4-nitrobenzoate With sodium methylate In methanol at 20℃; for 0.5h; Inert atmosphere;
Stage #2: With hydrogenchloride; tert-butyl methyl ether In methanol pH=7; Inert atmosphere;
2.37 g
C10H20O2Si

C10H20O2Si

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: sodium acetate; dihydrogen peroxide / tetrahydrofuran; water / 0.83 h / 0 - 20 °C / Inert atmosphere
1.2: Enzymatic reaction
2.1: 1H-imidazole / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
3.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere
5.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
7.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
8.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction
9.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
9.2: 4.17 h / -10 °C / Inert atmosphere
10.1: formic acid / 9 h / 50 °C / Inert atmosphere
11.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere
11.2: pH 7 / Inert atmosphere
View Scheme
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

ω-chlorocaprylic acid
1795-62-6

ω-chlorocaprylic acid

N-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-hydroxymethyl-2-methylene-cyclopentyl]-2-6H-purin-6-oneoctanamide

N-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-hydroxymethyl-2-methylene-cyclopentyl]-2-6H-purin-6-oneoctanamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 30℃; for 8h;74%
n-dodecanoyl chloride
112-16-3

n-dodecanoyl chloride

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

N-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-hydroxymethyl-2-methylene-cyclopentyl]-2-6H-purin-6-onelaurylamide

N-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-hydroxymethyl-2-methylene-cyclopentyl]-2-6H-purin-6-onelaurylamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 50℃; for 8h;68%
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

Reaxys ID: 30033682

Reaxys ID: 30033682

Reaxys ID: 30033679

Reaxys ID: 30033679

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(((S)-1-isopropoxycarbonylethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(((S)-1-isopropoxycarbonylethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 20 °C
2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C
View Scheme
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(((S)-1-cyclohexyloxycarbonylethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(((S)-1-cyclohexyloxycarbonylethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 20 °C
2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C
View Scheme
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-((methoxycarbonylmethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-((methoxycarbonylmethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 20 °C
2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C
View Scheme
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-((ethoxycarbonylmethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-((ethoxycarbonylmethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 20 °C
2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C
View Scheme
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-((isopropoxycarbonylmethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-((isopropoxycarbonylmethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 20 °C
2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C
View Scheme
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(((S)-1-ethoxycarbonylethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(((S)-1-ethoxycarbonylethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 20 °C
2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C
View Scheme
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

A

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(((R)-(1S)-1-ethoxycarbonylethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(((R)-(1S)-1-ethoxycarbonylethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

B

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(((S)-(1S)-1-ethoxycarbonylethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(((S)-(1S)-1-ethoxycarbonylethylamino(phenoxy)phosphoryl)oxymethyl)-2-methylidenecyclopentyl]-6H-purin-6-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 20 °C
2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C
3: Diacel's Chiralpak AS / acetonitrile; ethanol
View Scheme
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 20 °C
2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C
3: Diacel's Chiralpak AS / acetonitrile; isopropyl alcohol
View Scheme
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
142217-69-4

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

C15H20N6O3

C15H20N6O3

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃;
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