Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:142217-69-4
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryWe are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Entecavir from Wuhan, Hubei, China. It is made obtainabl
We are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical
Cas:142217-69-4
Min.Order:1 Gram
FOB Price: $10.0
Type:Manufacturers
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:142217-69-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:142217-69-4
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White to off-white powder Storage:-20°C Freezer Package:10g/b
Cas:142217-69-4
Min.Order:10 Gram
FOB Price: $40.0 / 50.0
Type:Trading Company
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:142217-69-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryAs a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:142217-69-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:142217-69-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:142217-69-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:142217-69-4
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:142217-69-4
Min.Order:0
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Type:Lab/Research institutions
inquiryChemical Name: Entecavir Molecular Formula: C12H15N5O3 Formula Weight: 277.283 CAS No.:142217-69-4;1367369-76-3 White to Off-White/Yellow Crystalline Powder Purity:99.5% Single impurity:NMT0.1% Total impurity:NMT0.3% Ad
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:142217-69-4
Min.Order:10 Gram
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Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:142217-69-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:142217-69-4
Min.Order:10 Gram
FOB Price: $0.6
Type:Trading Company
inquiryProduct Name: Entecavir CAS: 142217-69-4 MF: C12H15N5O3 MW: 277.28 EINECS: 604-279-5 Mol File: 142217-69-4.mol Entecavir Structure Entecavir Chemical Properties Melting point 249-252°C Boiling point 661.4±65.0 &
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:142217-69-4
Min.Order:1 Kilogram
FOB Price: $135.0 / 150.0
Type:Trading Company
inquiryEntecavir CAS:142217-69-4 .Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:142217-69-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Package:in aluminum bag and foil bag or as customers' require Application:142217-69-4 Transp
1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:142217-69-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe
Cas:142217-69-4
Min.Order:1 Kilogram
FOB Price: $20.0 / 40.0
Type:Trading Company
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
99%min Appearance:A white to nearly white crystalline powder Storage:Room temperature Package:as required Application:used medicine Transportation:by sea by air express Port:China main port
Cas:142217-69-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry((1 R,3S,5S)-5-acetoxy-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylenecyclopentyl)methyl acetate
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Stage #1: ((1 R,3S,5S)-5-acetoxy-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylenecyclopentyl)methyl acetate With sodium hydroxide at 80℃; for 2h; Stage #2: With hydrogenchloride In water at 0℃; pH=7; | 60% |
(1S,3R)-3-(tert-butyldimethylsilyloxy)-1-(oxiran-2-yl)pent-4-yn-1-ol
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: chloro-trimethyl-silane; 2,4,6-trimethyl-pyridine; zinc / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 2.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 3.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 4.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 5.1: sodium hydroxide / 2 h / 80 °C 5.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 6 steps 1.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 2.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C 3.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 4.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 5.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 6.1: sodium hydroxide / 2 h / 80 °C 6.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 7 steps 1.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 2.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere 3.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 4.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction 5.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere 5.2: 4.17 h / -10 °C / Inert atmosphere 6.1: formic acid / 9 h / 50 °C / Inert atmosphere 7.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 7.2: pH 7 / Inert atmosphere View Scheme |
(3S,5R)-7-(trimethylsilyl)hept-1-en-6-yne-3,5-diol
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: 1H-imidazole / tetrahydrofuran / 0 - 15 °C / Inert atmosphere 2.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 4.1: chloro-trimethyl-silane; 2,4,6-trimethyl-pyridine; zinc / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 5.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 6.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 7.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 8.1: sodium hydroxide / 2 h / 80 °C 8.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 8 steps 1.1: 1H-imidazole / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere 2.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 4.1: chloro-trimethyl-silane; 2,4,6-trimethyl-pyridine; zinc / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 5.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 6.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 7.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 8.1: sodium hydroxide / 2 h / 80 °C 8.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 9 steps 1.1: 1H-imidazole / tetrahydrofuran / 0 - 15 °C / Inert atmosphere 2.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 4.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 5.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C 6.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 7.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 8.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 9.1: sodium hydroxide / 2 h / 80 °C 9.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 9 steps 1.1: 1H-imidazole / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere 2.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 4.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 5.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C 6.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 7.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 8.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 9.1: sodium hydroxide / 2 h / 80 °C 9.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 10 steps 1.1: 1H-imidazole / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere 2.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 4.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 5.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere 6.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 7.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction 8.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere 8.2: 4.17 h / -10 °C / Inert atmosphere 9.1: formic acid / 9 h / 50 °C / Inert atmosphere 10.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 10.2: pH 7 / Inert atmosphere View Scheme |
(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(trimethylsilyl)hept-1-en-6-yn-3-ol
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 3.1: chloro-trimethyl-silane; 2,4,6-trimethyl-pyridine; zinc / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 4.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 5.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 6.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 7.1: sodium hydroxide / 2 h / 80 °C 7.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 8 steps 1.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 3.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 4.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C 5.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 6.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 7.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 8.1: sodium hydroxide / 2 h / 80 °C 8.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 9 steps 1.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 3.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 4.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere 5.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 6.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction 7.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere 7.2: 4.17 h / -10 °C / Inert atmosphere 8.1: formic acid / 9 h / 50 °C / Inert atmosphere 9.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 9.2: pH 7 / Inert atmosphere View Scheme |
(3S,5R)-5-(tert-butyldimethylsilyloxy)hept-1-en-6-yn-3-ol
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 2.1: chloro-trimethyl-silane; 2,4,6-trimethyl-pyridine; zinc / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 3.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 4.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 5.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 6.1: sodium hydroxide / 2 h / 80 °C 6.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 7 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 2.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 3.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C 4.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 5.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 6.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 7.1: sodium hydroxide / 2 h / 80 °C 7.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 8 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 2.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 3.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere 4.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 5.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction 6.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere 6.2: 4.17 h / -10 °C / Inert atmosphere 7.1: formic acid / 9 h / 50 °C / Inert atmosphere 8.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 8.2: pH 7 / Inert atmosphere View Scheme |
(1S,3R)-3-(tert-butyldimethylsilyloxy)-1-(oxiran-2-yl)pent-4-ynyl acetate
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: manganese; 2,4,6-collidine hydrochloride / bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 4 h / 20 °C 2.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 3.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 4.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 5.1: sodium hydroxide / 2 h / 80 °C 5.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 6 steps 1.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere 2.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 3.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction 4.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere 4.2: 4.17 h / -10 °C / Inert atmosphere 5.1: formic acid / 9 h / 50 °C / Inert atmosphere 6.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 6.2: pH 7 / Inert atmosphere View Scheme |
(1S,2R,4R)-4-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)-3-methylenecyclopentyl acetate
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 2.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 4.1: sodium hydroxide / 2 h / 80 °C 4.2: 0 °C / pH 7 View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction 3.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere 3.2: 4.17 h / -10 °C / Inert atmosphere 4.1: formic acid / 9 h / 50 °C / Inert atmosphere 5.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 5.2: pH 7 / Inert atmosphere View Scheme |
(1S,2R,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)-3-methylenecyclopentanol
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 2.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 4.1: sodium hydroxide / 2 h / 80 °C 4.2: 0 °C / pH 7 View Scheme |
((1R,3R,5S)-5-acetoxy-3-(tert-butyldimethylsilyloxy)-2-methylenecyclopentyl)methyl acetate
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: pyridine; hydrogen fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 2.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 3.1: sodium hydroxide / 2 h / 80 °C 3.2: 0 °C / pH 7 View Scheme |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 2.1: sodium hydroxide / 2 h / 80 °C 2.2: 0 °C / pH 7 View Scheme |
((1R,3R,5S)-5-acetoxy-3-(tert-butyldimethylsilyloxy)-2-methylenecyclopentyl)methyl 4-nitrobenzoate
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction 2.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere 2.2: 4.17 h / -10 °C / Inert atmosphere 3.1: formic acid / 9 h / 50 °C / Inert atmosphere 4.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 4.2: pH 7 / Inert atmosphere View Scheme |
((1R,3R,5S)-5-acetoxy-3-hydroxy-2-methylenecyclopentyl)methyl 4-nitrobenzoate
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere 1.2: 4.17 h / -10 °C / Inert atmosphere 2.1: formic acid / 9 h / 50 °C / Inert atmosphere 3.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 3.2: pH 7 / Inert atmosphere View Scheme |
((1R,3S,5S)-5-acetoxy-3-(2-amino-6-chloro-9H-purin-9-yl)-2-methylenecyclopentyl)methyl 4-nitrobenzoate
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: formic acid / 9 h / 50 °C / Inert atmosphere 2.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 2.2: pH 7 / Inert atmosphere View Scheme |
2-Amino-6-chloropurin
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere 1.2: 4.17 h / -10 °C / Inert atmosphere 2.1: formic acid / 9 h / 50 °C / Inert atmosphere 3.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 3.2: pH 7 / Inert atmosphere View Scheme |
((1R,3S,5S)-5-acetoxy-3-(2-amino-6-oxo-1H-purin-9(6H)-yl)-2-methylenecyclopentyl)methyl 4-nitrobenzoate
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Stage #1: ((1R,3S,5S)-5-acetoxy-3-(2-amino-6-oxo-1H-purin-9(6H)-yl)-2-methylenecyclopentyl)methyl 4-nitrobenzoate With sodium methylate In methanol at 20℃; for 0.5h; Inert atmosphere; Stage #2: With hydrogenchloride; tert-butyl methyl ether In methanol pH=7; Inert atmosphere; | 2.37 g |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: sodium acetate; dihydrogen peroxide / tetrahydrofuran; water / 0.83 h / 0 - 20 °C / Inert atmosphere 1.2: Enzymatic reaction 2.1: 1H-imidazole / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere 3.1: potassium carbonate; methanol / 1 h / 20 °C / Inert atmosphere 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere 5.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 6.1: 2,4,6-trimethyl-pyridine; zinc; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere 7.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 8.1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; methanol / 4 h / 0 - 20 °C / Inert atmosphere; Enzymatic reaction 9.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere 9.2: 4.17 h / -10 °C / Inert atmosphere 10.1: formic acid / 9 h / 50 °C / Inert atmosphere 11.1: sodium methylate / methanol / 0.5 h / 20 °C / Inert atmosphere 11.2: pH 7 / Inert atmosphere View Scheme |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
ω-chlorocaprylic acid
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 30℃; for 8h; | 74% |
n-dodecanoyl chloride
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 50℃; for 8h; | 68% |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 20 °C 2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C View Scheme |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 20 °C 2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C View Scheme |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 20 °C 2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C View Scheme |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 20 °C 2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C View Scheme |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 20 °C 2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C View Scheme |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 20 °C 2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C View Scheme |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 20 °C 2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C 3: Diacel's Chiralpak AS / acetonitrile; ethanol View Scheme | |
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 20 °C 2: 1-methyl-1H-imidazole / tetrahydrofuran / 20 °C 3: Diacel's Chiralpak AS / acetonitrile; isopropyl alcohol View Scheme |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-metylidenecyclopentyl]-3H-purin-6-one
N,N-dimethyl-formamide dimethyl acetal
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; |
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