We are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical
Cas:104227-87-4
Min.Order:1 Gram
FOB Price: $10.0
Type:Manufacturers
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:104227-87-4
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:104227-87-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Crystalline Powder Storage:-20°C Freezer Package:1kg/fo
Cas:104227-87-4
Min.Order:1 Kilogram
FOB Price: $500.0
Type:Trading Company
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Competitive Price Famciclovir powder Xi'an Quanao Biotech Co., Ltd. is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemi
Cas:104227-87-4
Min.Order:500 Gram
FOB Price: $10.0 / 15.0
Type:Manufacturers
inquiryFamciclovir English name: Famciclovir Chemical name: 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate Category involved: bulk pharmaceutical chemicals Struc
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:104227-87-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Famciclovir The alias:famcyclovir; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate CAS NO: 104227-87-4 Molecular formula:C14H19N5O4 Molecular weight:321.3318 Product Quality 12 years of chemical raw materials Mature operatio
Cas:104227-87-4
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:104227-87-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:104227-87-4
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:104227-87-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryKeywords 104227-87-4 good supplier of Famciclovir Famciclovir Quick Details ProName: Famciclovir CasNo: 104227-87-4 Molecular Formula: C14H19N5O4 Appearance: White crystalline powder
Cas:104227-87-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 3.0
Type:Trading Company
inquiry104227-87-4 Famciclovir product Name Famciclovir Synonyms famcyclovir; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate; Famciclov
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers
Cas:104227-87-4
Min.Order:100 Gram
Negotiable
Type:Other
inquiryWe are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Famciclovir from Wuhan, Hubei, China. It is made
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:104227-87-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: Famciclovir Synonyms: Famciclover;Amciclovir;FAMCICLOVIR;[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)-butyl] acetate;2-[2-(2-AMINO-9H-PURIN-9-YL)ETHYL]-1,3-PROPANEDIOL, DIACETATE ESTER;famcyclovir;[2-(acetyloxymethyl)-4-(2-aminopuri
About Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:104227-87-4
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiry1.Strong backup of factory:hign ability,favorable quality and competitive price. 2.Most of our products in catalogue are have stock. 3.Free sample could be provided. 4.Suitable package to protect the product the product quality. 5.the lead time
Cas:104227-87-4
Min.Order:1 Gram
FOB Price: $140.0 / 150.0
Type:Trading Company
inquiryFamciclovir CAS:104227-87-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:104227-87-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Product Detail Minimum Order Qty. 10 Gram
Cas:104227-87-4
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:104227-87-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried
Cas:104227-87-4
Min.Order:1 Kilogram
FOB Price: $20.0 / 30.0
Type:Trading Company
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:104227-87-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:104227-87-4
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:104227-87-4
Min.Order:1 Kilogram
FOB Price: $6.0 / 9.0
Type:Trading Company
inquiryacetic anhydride
6-deoxypenciclovir
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
With pyridine; dmap In tetrahydrofuran at 20℃; for 3h; | 97% |
With triethylamine In dichloromethane at 20 - 30℃; for 10h; | 90% |
With pyridine; dmap In tetrahydrofuran for 3h; Ambient temperature; | 74% |
Stage #1: 6-deoxypenciclovir With hydrogenchloride In water at 45 - 50℃; for 1.5h; Stage #2: With triethylamine In dichloromethane at 22 - 30℃; for 0.166667 - 0.25h; Stage #3: acetic anhydride With dmap In dichloromethane at 8 - 11℃; for 2.66667 - 2.75h; | |
With dmap; triethylamine In dichloromethane at 20℃; for 12h; |
acetic anhydride
orthoformic acid triethyl ester
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Stage #1: 2-(2-((2-amino-6-chloro-5-nitrosopyrimidine-4-yl)amino)ethyl)propane-1,3-diol With 5%-palladium/activated carbon; ammonium formate In ethyl acetate at 65℃; for 22h; Stage #2: orthoformic acid triethyl ester With acetic acid In ethyl acetate at 30℃; for 20h; Stage #3: acetic anhydride With dmap; triethylamine In ethyl acetate at 30℃; for 1.5h; Reagent/catalyst; Temperature; | 92.12% |
9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
With nickel In ethanol; water for 1h; Heating; | 91% |
acetic anhydride
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Stage #1: 2-amino-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine hydrochloride With triethylamine In dichloromethane at 10 - 20℃; Stage #2: acetic anhydride With dmap In dichloromethane at 5 - 20℃; | 91% |
With dmap; triethylamine In dichloromethane at 20℃; for 2h; Acetylation; | 80% |
Stage #1: 2-amino-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine hydrochloride With triethylamine In dichloromethane at 10 - 20℃; for 0.25 - 0.333333h; Stage #2: acetic anhydride With dmap In dichloromethane at 5 - 20℃; for 3h; |
6-deoxypenciclovir
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
With pyridine; dmap; acetic anhydride In tetrahydrofuran; methanol | 91% |
9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-chloro-9H-purine
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
With water; ammonium formate; palladium on charcoal In ethyl acetate for 2h; Product distribution / selectivity; | 90.9% |
With ammonium formate; palladium In methanol; water | 90% |
With ammonium formate; palladium 10% on activated carbon In methanol for 2h; Heating / reflux; | 90% |
acetic anhydride
diethyl 2-(2-(2-aminopurine-9-yl)ethyl)malonate
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
With pyridine; dmap; sodium tetrahydroborate Yield given. Multistep reaction; |
2-amino-7-benzyl-1H-purin-6(7H)-one
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 2: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 3: HCOONH4 / Pd/C / methanol / 4 h / Heating 4: aq. NaOH / 0.5 h / Heating 5: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 6: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 7: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 8: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 9: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
N2-acetyl-7-benzylguanine
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 2: HCOONH4 / Pd/C / methanol / 4 h / Heating 3: aq. NaOH / 0.5 h / Heating 4: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 5: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 6: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 7: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 8: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: 12.6 g / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 2.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 2.2: NH4OH / 1 h / Heating 3.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 4.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 5.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 6.1: aq. NaOH / 0.5 h / Heating 7.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 8.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 9.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 10.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 11.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
2-amino-1,9-dihydro-6H-purin-6-one
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1.1: 1-methyl-pyrrolidin-2-one / 4 h / 150 °C 2.1: 12.6 g / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 3.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 3.2: NH4OH / 1 h / Heating 4.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 5.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 6.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 7.1: aq. NaOH / 0.5 h / Heating 8.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 9.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 10.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 11.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 12.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 1.) trifluoroacetic anhydride / 1) pyridine, 0 deg C, 20 min; 2) pyridine, rt, 2 h 2: potassium carbonate / dimethylformamide / 18 h / 40 °C 3: 91 percent / Raney nickel / ethanol; H2O / 1 h / Heating View Scheme | |
Multi-step reaction with 6 steps 1: 1.) trifluoroacetic anhydride / 1) pyridine, 0 deg C, 20 min; 2) pyridine, rt, 2 h 2: 86.6 percent / potassium carbonate / dimethylsulfoxide / 1 h / 50 °C 3: 93 percent / potassium carbonate / dimethylsulfoxide / 1.5 h / 50 °C 4: 85 percent / NaBH4 / methanol; bis-(2-methoxy-ethyl) ether / 18 h / 50 °C 5: 96 percent / pyridine / 16 h / Ambient temperature 6: 91 percent / Raney nickel / ethanol; H2O / 1 h / Heating View Scheme | |
Multi-step reaction with 6 steps 1: trichlorophosphate / N,N-dimethyl-formamide / 6 h / 0 °C / Reflux 2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere 3: potassium carbonate / dimethyl sulfoxide / 4 h / 40 - 50 °C 4: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 7 h / 55 °C 5: methanol; sodium tetrahydroborate / dichloromethane / 2.5 h / 20 °C 6: dmap; triethylamine / dichloromethane / 12 h / 20 °C View Scheme |
Penciclovir
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 2: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 3: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 4: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 5: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
G
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: dimethylsulfoxide / 24 h / 20 °C 1.2: 85 percent / aq. HCl / dimethylsulfoxide / 2 h / 70 °C 2.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 3.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 4.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 5.1: aq. NaOH / 0.5 h / Heating 6.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 7.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 8.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 9.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 10.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
2-[(acetyloxy)methyl]-4-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)butyl acetate
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: aq. NaOH / 0.5 h / Heating 2: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 3: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 4: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 5: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 6: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
N2-acetyl-9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]guanine
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 2: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 3: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 4: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 2: HCOONH4 / Pd/C / methanol / 4 h / Heating 3: aq. NaOH / 0.5 h / Heating 4: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 5: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 6: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 7: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 8: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 2: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-9H-purine
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 2: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 3: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 1.2: NH4OH / 1 h / Heating 2.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 3.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 4.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 5.1: aq. NaOH / 0.5 h / Heating 6.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 7.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 8.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 9.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 10.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: HCOONH4 / Pd/C / methanol / 4 h / Heating 2: aq. NaOH / 0.5 h / Heating 3: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 4: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 5: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 6: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 7: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme |
3-hydroxymethyl-4-hydroxybutanal diethyl acetal
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: 83 percent / Dowex 50WX8-H(1+) resin / ethanol / 2 h / Heating 2.1: 99 percent / NEt3 / CH2Cl2 / 3 h / 0 - 20 °C 3.1: 47 percent / HCl / H2O; dioxane / 18 h / 20 °C 4.1: 95 percent / NEt3; DMAP; 3 Angstroem molecular sieves / acetonitrile / 1 h / 20 °C 5.1: bis(trimethylsilyl)acetamide / dimethylformamide / 1.5 h / 20 °C 5.2: 81 percent / TMSOTf / dimethylformamide / 3 h / 0 - 5 °C 6.1: 42 percent / aq. NaOH / dioxane / 4 h / 20 °C 7.1: DIBAL-H / tetrahydrofuran / 24 h / 20 °C 8.1: NEt3; DMAP / CH2Cl2 / 2 h / Heating 9.1: 81 percent / hydrogen; NEt3 / Pd/C / ethyl acetate / 4 h / 50 °C / 760 Torr View Scheme |
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
6-deoxypenciclovir
Conditions | Yield |
---|---|
With ammonia In methanol for 18h; Ambient temperature; | 96% |
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 14h; | 88% |
Ethyl boronic acid
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-ethylpurine
Conditions | Yield |
---|---|
With tris(2,2'-bipyridyl)ruthenium dichloride; 1-acetoxy-1,2-benziodoxol-3-one at 30℃; for 4h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation; | 70% |
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; trifluoroacetic acid In N,N-dimethyl acetamide at 20℃; for 6h; Schlenk technique; Inert atmosphere; Irradiation; regioselective reaction; | 54% |
Conditions | Yield |
---|---|
With 4,5,6,7-tetrafluoro-1-hydroxybenzo[d][1,2]iodaoxol-3(1H)-one; Ru(bpy)3Cl2 at 30℃; for 24h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation; regioselective reaction; | 53% |
Conditions | Yield |
---|---|
With tris(2,2'-bipyridyl)ruthenium dichloride; 1-acetoxy-1,2-benziodoxol-3-one at 30℃; for 7h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation; | 51% |
cyclohexylboronic acid
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
With tris(2,2'-bipyridyl)ruthenium dichloride; 1-acetoxy-1,2-benziodoxol-3-one at 30℃; for 4h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation; | 50% |
Cyclobutanecarboxylic acid
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Conditions | Yield |
---|---|
With copper(I) thiophene-2-carboxylate; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(5-methyl-2-(4-fluorophenyl)pyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; bathophenanthroline; iodomesitylene diacetate In 1,4-dioxane at 20℃; for 1h; Inert atmosphere; Irradiation; regioselective reaction; | 40% |
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
(R,S)-9-<4-acetoxy-3-(hydroxymethyl)but-1-yl>-2-aminopurine
Conditions | Yield |
---|---|
With potassium carbonate In methanol for 0.333333h; | 30% |
With esterase from Escherichia coli host strain; oxygen In dimethyl sulfoxide at 30℃; pH=7.4; Enzymatic reaction; |
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
B
(R,S)-9-<4-acetoxy-3-(hydroxymethyl)but-1-yl>-2-aminopurine
Conditions | Yield |
---|---|
With potassium carbonate In methanol; acetic acid | A n/a B 30% |
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
Penciclovir
Conditions | Yield |
---|---|
With oxygen In water for 2.5h; cows' milk xanthine oxidase, pH 7; Yield given; |
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