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Hubei Vanz Pharm Co.,Ltd

We are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical

CAS 104227-87-4 Famciclovir

Cas:104227-87-4

Min.Order:1 Gram

FOB Price: $10.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Famciclovir Manufacturer/High quality/Best price/In stock

Cas:104227-87-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Famciclovir 104227-87-4

Cas:104227-87-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Crystalline Powder Storage:-20°C Freezer Package:1kg/fo

High quality Famciclovir CAS 104227-87-4 supplied by reliable manufacturer

Cas:104227-87-4

Min.Order:1 Kilogram

FOB Price: $500.0

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Famciclovir CAS 104227-87-4

Cas:104227-87-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Quanao Biotech Co., Ltd.

Competitive Price Famciclovir powder Xi'an Quanao Biotech Co., Ltd. is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemi

Competitive Price Famciclovir powder

Cas:104227-87-4

Min.Order:500 Gram

FOB Price: $10.0 / 15.0

Type:Manufacturers

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EAST CHEMSOURCES LIMITED

Famciclovir English name: Famciclovir Chemical name: 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate Category involved: bulk pharmaceutical chemicals Struc

Famciclovir

Cas:104227-87-4

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Famciclovir 104227-87-4 GMP Manufacturer

Cas:104227-87-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Famciclovir

Cas:104227-87-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Famciclovir The alias:famcyclovir; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate CAS NO: 104227-87-4 Molecular formula:C14H19N5O4 Molecular weight:321.3318 Product Quality 12 years of chemical raw materials Mature operatio

Famciclovir/CAS:104227-87-4/Manufacturer

Cas:104227-87-4

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM_ Famciclovir,104227-87-4

Cas:104227-87-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Famciclovir

Cas:104227-87-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 104227-87-4 with competitive price

Cas:104227-87-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Keywords 104227-87-4 good supplier of Famciclovir Famciclovir Quick Details ProName: Famciclovir CasNo: 104227-87-4 Molecular Formula: C14H19N5O4 Appearance: White crystalline powder

Famciclovir CAS NO.104227-87-4

Cas:104227-87-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

104227-87-4 Famciclovir product Name Famciclovir Synonyms famcyclovir; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate; Famciclov

Famciclovir, 104227-87-4

Cas:104227-87-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

99% Purity Pharmaceutical Raw Materials Powder Famciclovir CAS 104227-87-4

Cas:104227-87-4

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Famciclovir from Wuhan, Hubei, China. It is made

Famciclovir

Cas:104227-87-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Famciclovir 104227-87-4

Cas:104227-87-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Famciclovir Synonyms: Famciclover;Amciclovir;FAMCICLOVIR;[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)-butyl] acetate;2-[2-(2-AMINO-9H-PURIN-9-YL)ETHYL]-1,3-PROPANEDIOL, DIACETATE ESTER;famcyclovir;[2-(acetyloxymethyl)-4-(2-aminopuri

Famciclovir

Cas:104227-87-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Famciclovir CAS 104227-87-4 For research Use only

Cas:104227-87-4

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

1.Strong backup of factory:hign ability,favorable quality and competitive price. 2.Most of our products in catalogue are have stock. 3.Free sample could be provided. 4.Suitable package to protect the product the product quality. 5.the lead time

Famciclovir CAS NO.104227-87-4

Cas:104227-87-4

Min.Order:1 Gram

FOB Price: $140.0 / 150.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Famciclovir CAS:104227-87-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Famciclovir CAS:104227-87-4

Cas:104227-87-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Famciclovir

Cas:104227-87-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Famciclovir Impurities CAS NO.104227-87-4

Cas:104227-87-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 104227-87-4 Famciclovir

Cas:104227-87-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:104227-87-4

Cas:104227-87-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

99% Famciclovir Powder Price CAS 104227-87-4

Cas:104227-87-4

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Famciclovir

Cas:104227-87-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Famciclovir

Cas:104227-87-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Famciclovir CAS 104227-87-4 with Fast Shipment

Cas:104227-87-4

Min.Order:1 Kilogram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Synthetic route

acetic anhydride
108-24-7

acetic anhydride

6-deoxypenciclovir
104227-86-3

6-deoxypenciclovir

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
With pyridine; dmap In tetrahydrofuran at 20℃; for 3h;97%
With triethylamine In dichloromethane at 20 - 30℃; for 10h;90%
With pyridine; dmap In tetrahydrofuran for 3h; Ambient temperature;74%
Stage #1: 6-deoxypenciclovir With hydrogenchloride In water at 45 - 50℃; for 1.5h;
Stage #2: With triethylamine In dichloromethane at 22 - 30℃; for 0.166667 - 0.25h;
Stage #3: acetic anhydride With dmap In dichloromethane at 8 - 11℃; for 2.66667 - 2.75h;
With dmap; triethylamine In dichloromethane at 20℃; for 12h;
2-(2-((2-amino-6-chloro-5-nitrosopyrimidine-4-yl)amino)ethyl)propane-1,3-diol

2-(2-((2-amino-6-chloro-5-nitrosopyrimidine-4-yl)amino)ethyl)propane-1,3-diol

acetic anhydride
108-24-7

acetic anhydride

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Stage #1: 2-(2-((2-amino-6-chloro-5-nitrosopyrimidine-4-yl)amino)ethyl)propane-1,3-diol With 5%-palladium/activated carbon; ammonium formate In ethyl acetate at 65℃; for 22h;
Stage #2: orthoformic acid triethyl ester With acetic acid In ethyl acetate at 30℃; for 20h;
Stage #3: acetic anhydride With dmap; triethylamine In ethyl acetate at 30℃; for 1.5h; Reagent/catalyst; Temperature;
92.12%
9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine
225111-66-0

9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-<(4-chlorophenyl)sulfanyl>-9H-purine

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
With nickel In ethanol; water for 1h; Heating;91%
acetic anhydride
108-24-7

acetic anhydride

2-amino-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine hydrochloride

2-amino-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine hydrochloride

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Stage #1: 2-amino-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine hydrochloride With triethylamine In dichloromethane at 10 - 20℃;
Stage #2: acetic anhydride With dmap In dichloromethane at 5 - 20℃;
91%
With dmap; triethylamine In dichloromethane at 20℃; for 2h; Acetylation;80%
Stage #1: 2-amino-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine hydrochloride With triethylamine In dichloromethane at 10 - 20℃; for 0.25 - 0.333333h;
Stage #2: acetic anhydride With dmap In dichloromethane at 5 - 20℃; for 3h;
6-deoxypenciclovir
104227-86-3

6-deoxypenciclovir

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
With pyridine; dmap; acetic anhydride In tetrahydrofuran; methanol91%
9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-chloro-9H-purine
97845-60-8

9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-chloro-9H-purine

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
With water; ammonium formate; palladium on charcoal In ethyl acetate for 2h; Product distribution / selectivity;90.9%
With ammonium formate; palladium In methanol; water90%
With ammonium formate; palladium 10% on activated carbon In methanol for 2h; Heating / reflux;90%
acetic anhydride
108-24-7

acetic anhydride

diethyl 2-(2-(2-aminopurine-9-yl)ethyl)malonate
122497-22-7

diethyl 2-(2-(2-aminopurine-9-yl)ethyl)malonate

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
With pyridine; dmap; sodium tetrahydroborate Yield given. Multistep reaction;
2-amino-7-benzyl-1H-purin-6(7H)-one
17495-12-4

2-amino-7-benzyl-1H-purin-6(7H)-one

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C
2: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C
3: HCOONH4 / Pd/C / methanol / 4 h / Heating
4: aq. NaOH / 0.5 h / Heating
5: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C
6: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
7: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
8: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
9: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
N2-acetyl-7-benzylguanine
17495-10-2

N2-acetyl-7-benzylguanine

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C
2: HCOONH4 / Pd/C / methanol / 4 h / Heating
3: aq. NaOH / 0.5 h / Heating
4: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C
5: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
6: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
7: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
8: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide
19962-37-9

N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: 12.6 g / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C
2.1: HCOONH4 / Pd/C / methanol / 4 h / Heating
2.2: NH4OH / 1 h / Heating
3.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C
4.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C
5.1: HCOONH4 / Pd/C / methanol / 4 h / Heating
6.1: aq. NaOH / 0.5 h / Heating
7.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C
8.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
9.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
10.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
11.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
2-amino-1,9-dihydro-6H-purin-6-one
73-40-5

2-amino-1,9-dihydro-6H-purin-6-one

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: 1-methyl-pyrrolidin-2-one / 4 h / 150 °C
2.1: 12.6 g / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C
3.1: HCOONH4 / Pd/C / methanol / 4 h / Heating
3.2: NH4OH / 1 h / Heating
4.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C
5.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C
6.1: HCOONH4 / Pd/C / methanol / 4 h / Heating
7.1: aq. NaOH / 0.5 h / Heating
8.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C
9.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
10.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
11.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
12.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 1.) trifluoroacetic anhydride / 1) pyridine, 0 deg C, 20 min; 2) pyridine, rt, 2 h
2: potassium carbonate / dimethylformamide / 18 h / 40 °C
3: 91 percent / Raney nickel / ethanol; H2O / 1 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: 1.) trifluoroacetic anhydride / 1) pyridine, 0 deg C, 20 min; 2) pyridine, rt, 2 h
2: 86.6 percent / potassium carbonate / dimethylsulfoxide / 1 h / 50 °C
3: 93 percent / potassium carbonate / dimethylsulfoxide / 1.5 h / 50 °C
4: 85 percent / NaBH4 / methanol; bis-(2-methoxy-ethyl) ether / 18 h / 50 °C
5: 96 percent / pyridine / 16 h / Ambient temperature
6: 91 percent / Raney nickel / ethanol; H2O / 1 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: trichlorophosphate / N,N-dimethyl-formamide / 6 h / 0 °C / Reflux
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere
3: potassium carbonate / dimethyl sulfoxide / 4 h / 40 - 50 °C
4: palladium 10% on activated carbon; hydrogen; triethylamine / methanol / 7 h / 55 °C
5: methanol; sodium tetrahydroborate / dichloromethane / 2.5 h / 20 °C
6: dmap; triethylamine / dichloromethane / 12 h / 20 °C
View Scheme
Penciclovir
39809-25-1

Penciclovir

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C
2: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
3: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
4: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
5: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: dimethylsulfoxide / 24 h / 20 °C
1.2: 85 percent / aq. HCl / dimethylsulfoxide / 2 h / 70 °C
2.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C
3.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C
4.1: HCOONH4 / Pd/C / methanol / 4 h / Heating
5.1: aq. NaOH / 0.5 h / Heating
6.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C
7.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
8.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
9.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
10.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
2-[(acetyloxy)methyl]-4-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)butyl acetate
97845-72-2

2-[(acetyloxy)methyl]-4-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)butyl acetate

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: aq. NaOH / 0.5 h / Heating
2: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C
3: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
4: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
5: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
6: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
N2-acetyl-9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]guanine
256945-18-3

N2-acetyl-9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]guanine

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
2: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
3: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
4: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
4-acetoxy-3-acetoxymethylbut-1-yl tosylate

4-acetoxy-3-acetoxymethylbut-1-yl tosylate

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C
2: HCOONH4 / Pd/C / methanol / 4 h / Heating
3: aq. NaOH / 0.5 h / Heating
4: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C
5: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
6: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
7: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
8: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
acetic acid 2-acetoxymethyl-4-(2-acetylamino-purin-9-yl)-butyl ester

acetic acid 2-acetoxymethyl-4-(2-acetylamino-purin-9-yl)-butyl ester

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
2: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-9H-purine
256945-19-4

9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-9H-purine

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
2: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
3: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
N2-acetyl-7,9-dibenzylguaninium bromide

N2-acetyl-7,9-dibenzylguaninium bromide

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: HCOONH4 / Pd/C / methanol / 4 h / Heating
1.2: NH4OH / 1 h / Heating
2.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C
3.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C
4.1: HCOONH4 / Pd/C / methanol / 4 h / Heating
5.1: aq. NaOH / 0.5 h / Heating
6.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C
7.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
8.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
9.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
10.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
9-(4-acetoxy-3-acetoxymethyl-butyl)-2-acetylamino-7-benzyl-6-oxo-6,7-dihydro-1H-purin-9-ium; bromide

9-(4-acetoxy-3-acetoxymethyl-butyl)-2-acetylamino-7-benzyl-6-oxo-6,7-dihydro-1H-purin-9-ium; bromide

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: HCOONH4 / Pd/C / methanol / 4 h / Heating
2: aq. NaOH / 0.5 h / Heating
3: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C
4: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C
5: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr
6: 99 percent / aq. MeNH2 / 0.25 h / 20 °C
7: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C
View Scheme
3-hydroxymethyl-4-hydroxybutanal diethyl acetal
55387-85-4

3-hydroxymethyl-4-hydroxybutanal diethyl acetal

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 83 percent / Dowex 50WX8-H(1+) resin / ethanol / 2 h / Heating
2.1: 99 percent / NEt3 / CH2Cl2 / 3 h / 0 - 20 °C
3.1: 47 percent / HCl / H2O; dioxane / 18 h / 20 °C
4.1: 95 percent / NEt3; DMAP; 3 Angstroem molecular sieves / acetonitrile / 1 h / 20 °C
5.1: bis(trimethylsilyl)acetamide / dimethylformamide / 1.5 h / 20 °C
5.2: 81 percent / TMSOTf / dimethylformamide / 3 h / 0 - 5 °C
6.1: 42 percent / aq. NaOH / dioxane / 4 h / 20 °C
7.1: DIBAL-H / tetrahydrofuran / 24 h / 20 °C
8.1: NEt3; DMAP / CH2Cl2 / 2 h / Heating
9.1: 81 percent / hydrogen; NEt3 / Pd/C / ethyl acetate / 4 h / 50 °C / 760 Torr
View Scheme
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

6-deoxypenciclovir
104227-86-3

6-deoxypenciclovir

Conditions
ConditionsYield
With ammonia In methanol for 18h; Ambient temperature;96%
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

benzoyl chloride
98-88-4

benzoyl chloride

C28H27N5O6

C28H27N5O6

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 14h;88%
Ethyl boronic acid
4433-63-0

Ethyl boronic acid

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-ethylpurine
131266-23-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-ethylpurine

Conditions
ConditionsYield
With tris(2,2'-bipyridyl)ruthenium dichloride; 1-acetoxy-1,2-benziodoxol-3-one at 30℃; for 4h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation;70%
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate

1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate

2-(2-(2-amino-6-cyclohexyl-9H-purin-9-yl)ethyl)propane-1,3-diyl diacetate

2-(2-(2-amino-6-cyclohexyl-9H-purin-9-yl)ethyl)propane-1,3-diyl diacetate

Conditions
ConditionsYield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; trifluoroacetic acid In N,N-dimethyl acetamide at 20℃; for 6h; Schlenk technique; Inert atmosphere; Irradiation; regioselective reaction;54%
oct-7-yn-1-ol
871-91-0

oct-7-yn-1-ol

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

C22H31N5O5

C22H31N5O5

Conditions
ConditionsYield
With 4,5,6,7-tetrafluoro-1-hydroxybenzo[d][1,2]iodaoxol-3(1H)-one; Ru(bpy)3Cl2 at 30℃; for 24h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation; regioselective reaction;53%
C8H14BNO3

C8H14BNO3

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

C22H30N6O5

C22H30N6O5

Conditions
ConditionsYield
With tris(2,2'-bipyridyl)ruthenium dichloride; 1-acetoxy-1,2-benziodoxol-3-one at 30℃; for 7h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation;51%
cyclohexylboronic acid
4441-56-9

cyclohexylboronic acid

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

2-(2-(2-amino-6-cyclohexyl-9H-purin-9-yl)ethyl)propane-1,3-diyl diacetate

2-(2-(2-amino-6-cyclohexyl-9H-purin-9-yl)ethyl)propane-1,3-diyl diacetate

Conditions
ConditionsYield
With tris(2,2'-bipyridyl)ruthenium dichloride; 1-acetoxy-1,2-benziodoxol-3-one at 30℃; for 4h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation;50%
Cyclobutanecarboxylic acid
3721-95-7

Cyclobutanecarboxylic acid

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

C18H25N5O4

C18H25N5O4

Conditions
ConditionsYield
With copper(I) thiophene-2-carboxylate; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(5-methyl-2-(4-fluorophenyl)pyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; bathophenanthroline; iodomesitylene diacetate In 1,4-dioxane at 20℃; for 1h; Inert atmosphere; Irradiation; regioselective reaction;40%
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

(R,S)-9-<4-acetoxy-3-(hydroxymethyl)but-1-yl>-2-aminopurine
120687-07-2

(R,S)-9-<4-acetoxy-3-(hydroxymethyl)but-1-yl>-2-aminopurine

Conditions
ConditionsYield
With potassium carbonate In methanol for 0.333333h;30%
With esterase from Escherichia coli host strain; oxygen In dimethyl sulfoxide at 30℃; pH=7.4; Enzymatic reaction;
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

A

9-(4-acetoxy-3-hydroxymethyl-1-yl)-2-aminopurine

9-(4-acetoxy-3-hydroxymethyl-1-yl)-2-aminopurine

B

(R,S)-9-<4-acetoxy-3-(hydroxymethyl)but-1-yl>-2-aminopurine
120687-07-2

(R,S)-9-<4-acetoxy-3-(hydroxymethyl)but-1-yl>-2-aminopurine

Conditions
ConditionsYield
With potassium carbonate In methanol; acetic acidA n/a
B 30%
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine
104227-87-4

9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine

Penciclovir
39809-25-1

Penciclovir

Conditions
ConditionsYield
With oxygen In water for 2.5h; cows' milk xanthine oxidase, pH 7; Yield given;
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