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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ganciclovir

Cas:82410-32-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Direct Antiviral Ganciclovir Powder

Cas:82410-32-0

Min.Order:1 Kilogram

FOB Price: $50.0 / 300.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White powder White powder Solubility Very slightly soluble

High purity Various Specifications Ganciclovir CAS:82410-32-0

Cas:82410-32-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Ganciclovir Cas 82410-32-0 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum

Reliable supplier high quality Ganciclovir Cas 82410-32-0 with favorable price

Cas:82410-32-0

Min.Order:1 Kilogram

FOB Price: $220.0 / 243.0

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

We are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical

CAS 82410-32-0 Ganciclovir

Cas:82410-32-0

Min.Order:1 Gram

FOB Price: $10.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Ganciclovir manufacturer with low price

Cas:82410-32-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Ganciclovir 82410-32-0 ISO Producer

Cas:82410-32-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

Ganciclovir

Cas:82410-32-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Ganciclovir

Cas:82410-32-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Ganciclovir -- CHemwill

Cas:82410-32-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Ganciclovir CAS no:82410-32-0 Grade:Scientific research and export Molecular formula:C9H13N5O4 Molecular weight:255.23100 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data stora

Ganciclovir/cas:82410-32-0 /high quality/Ganciclovir material

Cas:82410-32-0

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Ganciclovir/ LIDE PHARMA- Factory supply / Best price

Cas:82410-32-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM---Ganciclovir

Cas:82410-32-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Ganciclovir

Cas:82410-32-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 82410-32-0 with best quality

Cas:82410-32-0

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

82410-32-0 Ganciclovir product Name Ganciclovir Synonyms 2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 9-(

Ganciclovir, 82410-32-0

Cas:82410-32-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Antimex Chemical Limied

Ganciclovir (ganciclovir), the chemical name 9- (1, 3-dihydroxy-2-propoxymethyl) guanine, belongs to the nucleoside antiviral drugs, being a kind of guanosine derivatives. It has broad-spectrum, high-efficient inhibitory effects on herpes virus and

Ganciclovir

Cas:82410-32-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

Ganciclovir

Cas:82410-32-0

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White crystalline odourless powder Storage:ln stock Package:25kg/Barrel Application:Anti-virus and anti-infection Transportation:Express/Sea/Air Port:Any port in China

High quliaty 99.5% Anti-virus API Ganciclovir USP grade

Cas:82410-32-0

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Ganciclovir CAS NO 82410-32-0

Cas:82410-32-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Ganciclovir from Wuhan, Hubei, China. It is made obt

Ganciclovir

Cas:82410-32-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ganciclovir 82410-32-0

Cas:82410-32-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Quallity Antiviral Pharmaceutical Chemical Ganciclovir raw powder Ganciclovir

Cas:82410-32-0

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Ganciclovir Antiviral drugs

Cas:82410-32-0

Min.Order:1 Kilogram

FOB Price: $180.0 / 260.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Ganciclovir CAS: 82410-32-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Ganciclovir CAS: 82410-32-0

Cas:82410-32-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

factory Outlet CAS 82410-32-0 Ganciclovir

Cas:82410-32-0

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ganciclovir

Cas:82410-32-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

Good Price 99% Quality Ganciclovir CAS NO.82410-32-0

Cas:82410-32-0

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 82410-32-0 Ganciclovir

Cas:82410-32-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N2-acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine
84960-04-3

N2-acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
With ammonium hydroxide In methanol at 20℃; for 17h;94%
With ammonium hydroxide In methanol at 25℃; for 16h; Yield given;
9-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine
86357-14-4

9-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
With ammonium hydroxide for 72h; Ambient temperature;91%
With acetic acid In water; methylamine87%
With potassium hydroxide at 70℃; for 0.5h; Reagent/catalyst; Microwave irradiation;82.8%
With methanol; potassium hydroxide at 20℃; for 12h;78%
With acetic acid In methylamine
9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine
82410-31-9

9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
palladium dichloride In ethanol; cyclohexene for 5h; Heating;90%
With palladium; cyclohexene In ethanol87.7%
With cyclohexene; palladium In ethanol for 24h; Heating;87.7%
With cyclohexene; palladium In ethanol
9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine
82410-31-9

9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
With ethanol; palladium In cyclohexene for 18h; Heating;84%
N2-acetyl-9-((1,3-pivaloyloxy-2-propoxy)methyl)guanine
100675-29-4

N2-acetyl-9-((1,3-pivaloyloxy-2-propoxy)methyl)guanine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
With sodium methylate In methanol for 40h; Heating;72%
1-<(1,3-dihydroxy-2-propoxy)methyl>-5-<(thiocarbamoyl)amino>-1H-imidazole-4-carboxamide
131490-72-7

1-<(1,3-dihydroxy-2-propoxy)methyl>-5-<(thiocarbamoyl)amino>-1H-imidazole-4-carboxamide

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
With sodium hydroxide; copper(II) sulfate for 1h; Heating;61%
2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-1,3-bis-1'-propyl-(2'S)-azido-3'-methylbutanoate
1219792-39-8

2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-1,3-bis-1'-propyl-(2'S)-azido-3'-methylbutanoate

A

2-[(2-amino-1,6-dihydro-6-oxopurin-9-yl)methyloxy]-3-hydroxypropyl 2'-(S)-azido-3'-methylbutanoate
1219792-38-7

2-[(2-amino-1,6-dihydro-6-oxopurin-9-yl)methyloxy]-3-hydroxypropyl 2'-(S)-azido-3'-methylbutanoate

B

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In methanol at 20℃; for 14h;A 34.5%
B 20 %Chromat.
C23H21N5O6
86629-51-8

C23H21N5O6

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
With ammonia In methanol Yield given;
9-<<2-hydroxy-1-(hydroxymethyl)ethoxy>methyl>-2,6-diamino-purine
86629-59-6

9-<<2-hydroxy-1-(hydroxymethyl)ethoxy>methyl>-2,6-diamino-purine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
at 25℃; for 18h; adenosine deaminase, pH = 7.5;
9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine
88110-89-8

9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine

A

ganciclovir
82410-32-0

ganciclovir

B

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;
ganciclovir dipropionate

ganciclovir dipropionate

A

ganciclovir
82410-32-0

ganciclovir

B

propionic acid
802294-64-0

propionic acid

Conditions
ConditionsYield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;
9-(1,3-diacetoxy-2-propoxymethyl)guanine
86357-19-9

9-(1,3-diacetoxy-2-propoxymethyl)guanine

A

ganciclovir
82410-32-0

ganciclovir

B

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;
ganciclovir dibutyrate
88110-71-8

ganciclovir dibutyrate

A

ganciclovir
82410-32-0

ganciclovir

B

butyric acid
107-92-6

butyric acid

Conditions
ConditionsYield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;
ganciclovir monopropionate
194159-18-7

ganciclovir monopropionate

A

ganciclovir
82410-32-0

ganciclovir

B

propionic acid
802294-64-0

propionic acid

Conditions
ConditionsYield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;
ganciclovir diisobutyrate

ganciclovir diisobutyrate

A

ganciclovir
82410-32-0

ganciclovir

B

isobutyric Acid
79-31-2

isobutyric Acid

Conditions
ConditionsYield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;
ganciclovir monobutyrate
298197-24-7

ganciclovir monobutyrate

A

ganciclovir
82410-32-0

ganciclovir

B

butyric acid
107-92-6

butyric acid

Conditions
ConditionsYield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;
ganciclovir monovalerate

ganciclovir monovalerate

A

ganciclovir
82410-32-0

ganciclovir

B

valeric acid
109-52-4

valeric acid

Conditions
ConditionsYield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;
2-amino-1,9-dihydro-6H-purin-6-one
73-40-5

2-amino-1,9-dihydro-6H-purin-6-one

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (NH4)2SO4
2: Bu4NF / tetrahydrofuran
3: cyclohexene / Pd / ethanol
View Scheme
Multi-step reaction with 3 steps
1: ammonium sulfate / 96 h / Heating
2: 17.8 percent / tetrabutylammonium fluoride / tetrahydrofuran / 22 h / Heating
3: 87.7 percent / cyclohexene / palladium black / ethanol / 24 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: (NH4)2SO4
2: Bu4NF / tetrahydrofuran
3: 87.7 percent / Pd black; cyclohexene / ethanol
View Scheme
2,6,9-tris(trimethylsilyl)guanine
18602-85-2

2,6,9-tris(trimethylsilyl)guanine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Bu4NF / tetrahydrofuran
2: cyclohexene / Pd / ethanol
View Scheme
Multi-step reaction with 2 steps
1: 17.8 percent / tetrabutylammonium fluoride / tetrahydrofuran / 22 h / Heating
2: 87.7 percent / cyclohexene / palladium black / ethanol / 24 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: Bu4NF / tetrahydrofuran
2: 87.7 percent / Pd black; cyclohexene / ethanol
View Scheme
N2-acetyl-9-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine
82410-30-8

N2-acetyl-9-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / EtOH / Pd(OH)2/C / cyclohexane / 40 h / Heating
2: 94 percent / aq. ammonium hydroxide / methanol / 17 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 20percent Pd(OH)2/C / cyclohexene; ethanol / 32 h / Heating
2: 56percent NH4OH / methanol / 16 h / 25 °C
View Scheme
Multi-step reaction with 2 steps
1: 99 percent / conc. ammonium hydroxide, pyridine / 15 h / 55 °C
2: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating
View Scheme
2,9-diacetylguanine
3056-33-5

2,9-diacetylguanine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 31 percent / p-toluenesulfonic acid / tetrahydrothiophene 1,1-dioxide / 85 h / 95 °C
2: 90 percent / EtOH / Pd(OH)2/C / cyclohexane / 40 h / Heating
3: 94 percent / aq. ammonium hydroxide / methanol / 17 h / 20 °C
View Scheme
7-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine
86357-17-7

7-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 50 percent / 0.17 h / 230 °C
2: 91 percent / NH4OH / 72 h / Ambient temperature
View Scheme
N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide
19962-37-9

N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) HMDS, ammonium sulfate; 2.) TBAI; 3.)methanol, water
2: 99 percent / conc. ammonium hydroxide, pyridine / 15 h / 55 °C
3: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C
2: palladium diacetate; bis(tertbutylcarbonyloxy)iodobenzene / toluene / 24 h / 120 °C
3: methanol; potassium hydroxide / 12 h / 20 °C
View Scheme
2,6-bisacetamidopurine
34097-37-5

2,6-bisacetamidopurine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 5.4 g / triethylamine / dimethylformamide / 1.) r.t. 60 h; 2.) 40 deg C, 1 h
2: 85 percent / Na / methanol / 1.) reflux, 2 h; 2.) r.t. 12 h
3: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating
4: 18 h / 25 °C / adenosine deaminase, pH = 7.5
View Scheme
9-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-9H-purine-2,6-diamine
89419-14-7

9-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-9H-purine-2,6-diamine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating
2: 18 h / 25 °C / adenosine deaminase, pH = 7.5
View Scheme
N-[2-Acetylamino-9-(2-benzyloxy-1-benzyloxymethyl-ethoxymethyl)-9H-purin-6-yl]-acetamide
89419-13-6

N-[2-Acetylamino-9-(2-benzyloxy-1-benzyloxymethyl-ethoxymethyl)-9H-purin-6-yl]-acetamide

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85 percent / Na / methanol / 1.) reflux, 2 h; 2.) r.t. 12 h
2: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating
3: 18 h / 25 °C / adenosine deaminase, pH = 7.5
View Scheme
9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>-methyl>-6-chloroguanine
84222-47-9

9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>-methyl>-6-chloroguanine

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / sodium, mercaptoethanol, water / methanol / 2.5 h / Heating
2: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating
View Scheme
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) 1,1,1,3,3,3-hexamethyldisilazane, ammonium sulfate; 2.) mercuric cyanide / 1.) 2 h, reflux; 2.) benzene, 3 h, reflux
2: 70 percent / sodium, mercaptoethanol, water / methanol / 2.5 h / Heating
3: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating
View Scheme
5-amino-1-<(1,3-dihydroxy-2-propoxy)methyl>-1H-imidazole-4-carboxamide
131490-62-5

5-amino-1-<(1,3-dihydroxy-2-propoxy)methyl>-1H-imidazole-4-carboxamide

ganciclovir
82410-32-0

ganciclovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2) K2CO3 / 1) acetone, reflux, 1 h, 2) methanol, reflux, 4 h
2: 61 percent / 3N aq. NaOH, copper(II) sulfate / 1 h / Heating
View Scheme
ganciclovir
82410-32-0

ganciclovir

2-Methylpropionic anhydride
97-72-3

2-Methylpropionic anhydride

isobutyric acid 2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-isobutyryloxy-propyl ester

isobutyric acid 2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-isobutyryloxy-propyl ester

Conditions
ConditionsYield
With pyridine; dmap for 1h; Acylation; Heating;99%
ganciclovir
82410-32-0

ganciclovir

1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

Hexadecanoic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-hexadecanoyloxy-propyl ester

Hexadecanoic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-hexadecanoyloxy-propyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 50℃; for 50h;97%
tert-butoxyphosphonic acid dichloride

tert-butoxyphosphonic acid dichloride

ganciclovir
82410-32-0

ganciclovir

C13H22N5O7P

C13H22N5O7P

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 50℃; for 5h; Inert atmosphere;96.8%
ganciclovir
82410-32-0

ganciclovir

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

9-<(1,3-bis(tert-butyldimethylsilyloxy)-2-propoxy)methyl>guanine
109082-88-4

9-<(1,3-bis(tert-butyldimethylsilyloxy)-2-propoxy)methyl>guanine

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide for 1h; Ambient temperature;95%
ganciclovir
82410-32-0

ganciclovir

C9H11Cl2N5O2

C9H11Cl2N5O2

Conditions
ConditionsYield
With phosphorus pentachloride In tetrahydrofuran at 0 - 10℃; for 1h;92.7%
ganciclovir
82410-32-0

ganciclovir

acetic anhydride
108-24-7

acetic anhydride

9-(1,3-diacetoxy-2-propoxymethyl)guanine
86357-19-9

9-(1,3-diacetoxy-2-propoxymethyl)guanine

Conditions
ConditionsYield
With dmap Ambient temperature;91%
With dmap In N,N-dimethyl-formamide at 23℃; Acetylation;90%
ganciclovir
82410-32-0

ganciclovir

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-ethoxymethyl]-1,9-dihydro-purin-6-one
266684-38-2

2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-ethoxymethyl]-1,9-dihydro-purin-6-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 24h; Substitution; silylation;91%
trimethyl orthovalerate
13820-09-2

trimethyl orthovalerate

ganciclovir
82410-32-0

ganciclovir

A

ganciclovir monovalerate

ganciclovir monovalerate

B

pentanoic acid 3-hydroxy-2-(6-oxo-2-pentanoylamino-1,6-dihydro-purin-9-ylmethoxy)-propyl ester

pentanoic acid 3-hydroxy-2-(6-oxo-2-pentanoylamino-1,6-dihydro-purin-9-ylmethoxy)-propyl ester

Conditions
ConditionsYield
Stage #1: trimethyl orthovalerate; ganciclovir With trifluoroacetic acid In N,N-dimethyl-formamide at 23℃; for 2h; Substitution;
Stage #2: With water In N,N-dimethyl-formamide at 23℃; Hydrolysis;
A 90%
B 5%
ganciclovir
82410-32-0

ganciclovir

azidovaline
40224-47-3

azidovaline

2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-1,3-bis-1'-propyl-(2'S)-azido-3'-methylbutanoate
1219792-39-8

2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-1,3-bis-1'-propyl-(2'S)-azido-3'-methylbutanoate

Conditions
ConditionsYield
Stage #1: ganciclovir With benzotriazol-1-ol; triethylamine In dimethyl sulfoxide at 25 - 30℃; for 0.166667h;
Stage #2: azidovaline In dimethyl sulfoxide at 25 - 30℃;
Stage #3: With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 25 - 30℃; for 2h;
88.8%
Stage #1: ganciclovir With triethanolamine; benzotriazol-1-ol In dimethyl sulfoxide at 25 - 30℃;
Stage #2: azidovaline With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20 - 30℃;
ganciclovir
82410-32-0

ganciclovir

propionic acid anhydride
123-62-6

propionic acid anhydride

ganciclovir dipropionate

ganciclovir dipropionate

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 23℃; Esterification;88%
With dmap Ambient temperature;52%
ganciclovir
82410-32-0

ganciclovir

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

9-<(1,3-di(imidazol-1-ylcarbonyloxy)-2-propoxy)methyl>guanine

9-<(1,3-di(imidazol-1-ylcarbonyloxy)-2-propoxy)methyl>guanine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 50℃; for 18h;87%
trimethoxypropane
24823-81-2

trimethoxypropane

ganciclovir
82410-32-0

ganciclovir

A

ganciclovir monopropionate
194159-18-7

ganciclovir monopropionate

B

propionic acid 3-hydroxy-2-(6-oxo-2-propionylamino-1,6-dihydro-purin-9-ylmethoxy)-propyl ester

propionic acid 3-hydroxy-2-(6-oxo-2-propionylamino-1,6-dihydro-purin-9-ylmethoxy)-propyl ester

Conditions
ConditionsYield
Stage #1: trimethoxypropane; ganciclovir With trifluoroacetic acid In N,N-dimethyl-formamide at 23℃; for 2h; Substitution;
Stage #2: With water In N,N-dimethyl-formamide at 23℃; Hydrolysis;
A 87%
B 6%
butanoic acid anhydride
106-31-0

butanoic acid anhydride

ganciclovir
82410-32-0

ganciclovir

ganciclovir dibutyrate
88110-71-8

ganciclovir dibutyrate

Conditions
ConditionsYield
With dmap Ambient temperature;86%
With dmap In N,N-dimethyl-formamide at 23℃; Esterification;80%
ganciclovir
82410-32-0

ganciclovir

4-isobutyryloxyphenacyl bromide
476360-57-3

4-isobutyryloxyphenacyl bromide

isobutyric acid 4-[3-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-8-oxo-5,8-dihydro-3H-1,3,4,5,7a-pentaaza-s-indacen-6-yl]-phenyl ester
476360-70-0

isobutyric acid 4-[3-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-8-oxo-5,8-dihydro-3H-1,3,4,5,7a-pentaaza-s-indacen-6-yl]-phenyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide86%
Stage #1: ganciclovir With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 4-isobutyryloxyphenacyl bromide In N,N-dimethyl-formamide at 20℃; for 4h; Further stages.;
55%
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 4h;
ganciclovir
82410-32-0

ganciclovir

2,2-dimethylpropanoic anhydride
1538-75-6

2,2-dimethylpropanoic anhydride

9-<(1,3-dipivaloyloxy-2-propoxy)methyl>guanine

9-<(1,3-dipivaloyloxy-2-propoxy)methyl>guanine

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide for 48h; Ambient temperature;84%
ganciclovir
82410-32-0

ganciclovir

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

N'-(9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylmethanimidamide

N'-(9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylmethanimidamide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 29h;84%
1,1,1-trimethoxybutane
43083-12-1

1,1,1-trimethoxybutane

ganciclovir
82410-32-0

ganciclovir

A

ganciclovir monobutyrate
298197-24-7

ganciclovir monobutyrate

B

butyric acid 2-(2-butyrylamino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-hydroxy-propyl ester

butyric acid 2-(2-butyrylamino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-hydroxy-propyl ester

Conditions
ConditionsYield
Stage #1: 1,1,1-trimethoxybutane; ganciclovir With trifluoroacetic acid In N,N-dimethyl-formamide at 23℃; for 2h; Substitution;
Stage #2: With water In N,N-dimethyl-formamide at 23℃; Hydrolysis;
A 83%
B 15%
ganciclovir
82410-32-0

ganciclovir

N-(Benzyloxycarbonyl)glycine
1138-80-3

N-(Benzyloxycarbonyl)glycine

Benzyloxycarbonylamino-acetic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(2-benzyloxycarbonylamino-acetoxy)-propyl ester

Benzyloxycarbonylamino-acetic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(2-benzyloxycarbonylamino-acetoxy)-propyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 48h; Acylation;81%
ganciclovir
82410-32-0

ganciclovir

2-Methylpropionic anhydride
97-72-3

2-Methylpropionic anhydride

ganciclovir diisobutyrate

ganciclovir diisobutyrate

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 23℃; Esterification;80%
ganciclovir
82410-32-0

ganciclovir

acetic anhydride
108-24-7

acetic anhydride

9-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine
86357-14-4

9-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine

Conditions
ConditionsYield
With pyridine for 6h; Reflux;80%
undecylenic acid
112-37-8

undecylenic acid

ganciclovir
82410-32-0

ganciclovir

undecanoic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-undecanoyloxy-propyl ester

undecanoic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-undecanoyloxy-propyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 23℃; for 48h; Esterification;78%
benzaldehyde dimethyl acetal
1125-88-8

benzaldehyde dimethyl acetal

ganciclovir
82410-32-0

ganciclovir

2-amino-9-((2-phenyl-1,3-dioxan-5-yloxy)methyl)-1H-purin-6(9H)-one

2-amino-9-((2-phenyl-1,3-dioxan-5-yloxy)methyl)-1H-purin-6(9H)-one

Conditions
ConditionsYield
Stage #1: benzaldehyde dimethyl acetal; ganciclovir With toluene-4-sulfonic acid In dimethyl sulfoxide at 25 - 80℃;
Stage #2: With triethylamine In water; dimethyl sulfoxide; ethyl acetate at 25 - 35℃;
78%
Isovaleric anhydride
1468-39-9

Isovaleric anhydride

ganciclovir
82410-32-0

ganciclovir

2-N-isobutyryl-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}guanine

2-N-isobutyryl-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}guanine

Conditions
ConditionsYield
Stage #1: ganciclovir With pyridine; chloro-trimethyl-silane at 20℃; for 0.25h;
Stage #2: Isovaleric anhydride at 20℃; for 3h;
Stage #3: With ammonia In water
76.8%
N-Acetylimidazole
2466-76-4

N-Acetylimidazole

ganciclovir
82410-32-0

ganciclovir

9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine
88110-89-8

9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine

Conditions
ConditionsYield
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux; Large scale;
Stage #2: N-Acetylimidazole With triethylamine at 20℃; for 6h; Large scale;
Stage #3: In methanol at 0 - 20℃; for 2h; Reagent/catalyst; Solvent; Large scale;
75.7%
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux;
Stage #2: N-Acetylimidazole With triethylamine In toluene at 20℃; for 6h;
Stage #3: With methanol In toluene at 0 - 20℃; for 2h; Reagent/catalyst; Solvent;
75.7%
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux;
Stage #2: N-Acetylimidazole With triethylamine In toluene at 20℃; for 6h;
Stage #3: With methanol In toluene at 0 - 20℃; for 2h; Reagent/catalyst; Solvent;
75.7%
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux;
Stage #2: N-Acetylimidazole With triethylamine In toluene at 20℃; for 6h; Reagent/catalyst; Solvent;
75.7%
vinyl acetate
108-05-4

vinyl acetate

ganciclovir
82410-32-0

ganciclovir

9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine
88110-89-8

9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine

Conditions
ConditionsYield
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux; Large scale;
Stage #2: vinyl acetate With triethylamine at 20℃; for 6h; Large scale;
Stage #3: In ethanol at 0 - 20℃; for 3h; Reagent/catalyst; Solvent; Large scale;
75.2%
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux;
Stage #2: vinyl acetate With triethylamine In 2-methyltetrahydrofuran at 20℃; for 6h;
Stage #3: With ethanol In 2-methyltetrahydrofuran at 0 - 20℃; for 2h; Reagent/catalyst; Solvent;
75.2%
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux;
Stage #2: vinyl acetate With triethylamine In tetrahydrofuran at 20℃; for 6h;
Stage #3: With ethanol In tetrahydrofuran at 0 - 20℃; for 3h; Reagent/catalyst; Solvent;
75.2%
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux;
Stage #2: vinyl acetate With triethylamine In 2-methyltetrahydrofuran at 20℃; for 6h; Reagent/catalyst; Solvent;
75.2%
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