As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:82410-32-0
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inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:82410-32-0
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inquiryItems Standard Result Appearance White powder White powder Solubility Very slightly soluble
Cas:82410-32-0
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inquiryUnique advantages for Ganciclovir Cas 82410-32-0 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum
Cas:82410-32-0
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inquiryWe are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical
Cas:82410-32-0
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:82410-32-0
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:82410-32-0
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Cas:82410-32-0
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inquiryName:Ganciclovir CAS no:82410-32-0 Grade:Scientific research and export Molecular formula:C9H13N5O4 Molecular weight:255.23100 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data stora
Cas:82410-32-0
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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Min.Order:1 Gram
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:82410-32-0
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:82410-32-0
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Type:Trading Company
inquiry82410-32-0 Ganciclovir product Name Ganciclovir Synonyms 2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 9-(
Ganciclovir (ganciclovir), the chemical name 9- (1, 3-dihydroxy-2-propoxymethyl) guanine, belongs to the nucleoside antiviral drugs, being a kind of guanosine derivatives. It has broad-spectrum, high-efficient inhibitory effects on herpes virus and
1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
Appearance:White crystalline odourless powder Storage:ln stock Package:25kg/Barrel Application:Anti-virus and anti-infection Transportation:Express/Sea/Air Port:Any port in China
Cas:82410-32-0
Min.Order:1 Kilogram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Ganciclovir from Wuhan, Hubei, China. It is made obt
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:82410-32-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:82410-32-0
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:82410-32-0
Min.Order:1 Kilogram
FOB Price: $180.0 / 260.0
Type:Trading Company
inquiryGanciclovir CAS: 82410-32-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:82410-32-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful
Cas:82410-32-0
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,
Cas:82410-32-0
Min.Order:20 Metric Ton
Negotiable
Type:Trading Company
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:82410-32-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryN2-acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine
ganciclovir
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol at 20℃; for 17h; | 94% |
With ammonium hydroxide In methanol at 25℃; for 16h; Yield given; |
9-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine
ganciclovir
Conditions | Yield |
---|---|
With ammonium hydroxide for 72h; Ambient temperature; | 91% |
With acetic acid In water; methylamine | 87% |
With potassium hydroxide at 70℃; for 0.5h; Reagent/catalyst; Microwave irradiation; | 82.8% |
With methanol; potassium hydroxide at 20℃; for 12h; | 78% |
With acetic acid In methylamine |
9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine
ganciclovir
Conditions | Yield |
---|---|
palladium dichloride In ethanol; cyclohexene for 5h; Heating; | 90% |
With palladium; cyclohexene In ethanol | 87.7% |
With cyclohexene; palladium In ethanol for 24h; Heating; | 87.7% |
With cyclohexene; palladium In ethanol |
9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine
ganciclovir
Conditions | Yield |
---|---|
With ethanol; palladium In cyclohexene for 18h; Heating; | 84% |
N2-acetyl-9-((1,3-pivaloyloxy-2-propoxy)methyl)guanine
ganciclovir
Conditions | Yield |
---|---|
With sodium methylate In methanol for 40h; Heating; | 72% |
1-<(1,3-dihydroxy-2-propoxy)methyl>-5-<(thiocarbamoyl)amino>-1H-imidazole-4-carboxamide
ganciclovir
Conditions | Yield |
---|---|
With sodium hydroxide; copper(II) sulfate for 1h; Heating; | 61% |
2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-1,3-bis-1'-propyl-(2'S)-azido-3'-methylbutanoate
A
2-[(2-amino-1,6-dihydro-6-oxopurin-9-yl)methyloxy]-3-hydroxypropyl 2'-(S)-azido-3'-methylbutanoate
B
ganciclovir
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In methanol at 20℃; for 14h; | A 34.5% B 20 %Chromat. |
C23H21N5O6
ganciclovir
Conditions | Yield |
---|---|
With ammonia In methanol Yield given; |
9-<<2-hydroxy-1-(hydroxymethyl)ethoxy>methyl>-2,6-diamino-purine
ganciclovir
Conditions | Yield |
---|---|
at 25℃; for 18h; adenosine deaminase, pH = 7.5; |
9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine
A
ganciclovir
B
acetic acid
Conditions | Yield |
---|---|
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents; |
Conditions | Yield |
---|---|
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents; |
Conditions | Yield |
---|---|
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents; |
Conditions | Yield |
---|---|
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents; |
Conditions | Yield |
---|---|
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents; |
Conditions | Yield |
---|---|
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents; |
Conditions | Yield |
---|---|
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents; |
Conditions | Yield |
---|---|
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents; |
2-amino-1,9-dihydro-6H-purin-6-one
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: (NH4)2SO4 2: Bu4NF / tetrahydrofuran 3: cyclohexene / Pd / ethanol View Scheme | |
Multi-step reaction with 3 steps 1: ammonium sulfate / 96 h / Heating 2: 17.8 percent / tetrabutylammonium fluoride / tetrahydrofuran / 22 h / Heating 3: 87.7 percent / cyclohexene / palladium black / ethanol / 24 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: (NH4)2SO4 2: Bu4NF / tetrahydrofuran 3: 87.7 percent / Pd black; cyclohexene / ethanol View Scheme |
2,6,9-tris(trimethylsilyl)guanine
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Bu4NF / tetrahydrofuran 2: cyclohexene / Pd / ethanol View Scheme | |
Multi-step reaction with 2 steps 1: 17.8 percent / tetrabutylammonium fluoride / tetrahydrofuran / 22 h / Heating 2: 87.7 percent / cyclohexene / palladium black / ethanol / 24 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: Bu4NF / tetrahydrofuran 2: 87.7 percent / Pd black; cyclohexene / ethanol View Scheme |
N2-acetyl-9-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / EtOH / Pd(OH)2/C / cyclohexane / 40 h / Heating 2: 94 percent / aq. ammonium hydroxide / methanol / 17 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 20percent Pd(OH)2/C / cyclohexene; ethanol / 32 h / Heating 2: 56percent NH4OH / methanol / 16 h / 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: 99 percent / conc. ammonium hydroxide, pyridine / 15 h / 55 °C 2: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating View Scheme |
2,9-diacetylguanine
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 31 percent / p-toluenesulfonic acid / tetrahydrothiophene 1,1-dioxide / 85 h / 95 °C 2: 90 percent / EtOH / Pd(OH)2/C / cyclohexane / 40 h / Heating 3: 94 percent / aq. ammonium hydroxide / methanol / 17 h / 20 °C View Scheme |
7-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 50 percent / 0.17 h / 230 °C 2: 91 percent / NH4OH / 72 h / Ambient temperature View Scheme |
N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) HMDS, ammonium sulfate; 2.) TBAI; 3.)methanol, water 2: 99 percent / conc. ammonium hydroxide, pyridine / 15 h / 55 °C 3: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C 2: palladium diacetate; bis(tertbutylcarbonyloxy)iodobenzene / toluene / 24 h / 120 °C 3: methanol; potassium hydroxide / 12 h / 20 °C View Scheme |
2,6-bisacetamidopurine
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 5.4 g / triethylamine / dimethylformamide / 1.) r.t. 60 h; 2.) 40 deg C, 1 h 2: 85 percent / Na / methanol / 1.) reflux, 2 h; 2.) r.t. 12 h 3: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating 4: 18 h / 25 °C / adenosine deaminase, pH = 7.5 View Scheme |
9-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-9H-purine-2,6-diamine
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating 2: 18 h / 25 °C / adenosine deaminase, pH = 7.5 View Scheme |
N-[2-Acetylamino-9-(2-benzyloxy-1-benzyloxymethyl-ethoxymethyl)-9H-purin-6-yl]-acetamide
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 85 percent / Na / methanol / 1.) reflux, 2 h; 2.) r.t. 12 h 2: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating 3: 18 h / 25 °C / adenosine deaminase, pH = 7.5 View Scheme |
9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>-methyl>-6-chloroguanine
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / sodium, mercaptoethanol, water / methanol / 2.5 h / Heating 2: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating View Scheme |
2-Amino-6-chloropurin
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) 1,1,1,3,3,3-hexamethyldisilazane, ammonium sulfate; 2.) mercuric cyanide / 1.) 2 h, reflux; 2.) benzene, 3 h, reflux 2: 70 percent / sodium, mercaptoethanol, water / methanol / 2.5 h / Heating 3: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating View Scheme |
5-amino-1-<(1,3-dihydroxy-2-propoxy)methyl>-1H-imidazole-4-carboxamide
ganciclovir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2) K2CO3 / 1) acetone, reflux, 1 h, 2) methanol, reflux, 4 h 2: 61 percent / 3N aq. NaOH, copper(II) sulfate / 1 h / Heating View Scheme |
ganciclovir
2-Methylpropionic anhydride
Conditions | Yield |
---|---|
With pyridine; dmap for 1h; Acylation; Heating; | 99% |
ganciclovir
1-hexadecylcarboxylic acid
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 50℃; for 50h; | 97% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 50℃; for 5h; Inert atmosphere; | 96.8% |
ganciclovir
tert-butyldimethylsilyl chloride
9-<(1,3-bis(tert-butyldimethylsilyloxy)-2-propoxy)methyl>guanine
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide for 1h; Ambient temperature; | 95% |
ganciclovir
Conditions | Yield |
---|---|
With phosphorus pentachloride In tetrahydrofuran at 0 - 10℃; for 1h; | 92.7% |
ganciclovir
acetic anhydride
9-(1,3-diacetoxy-2-propoxymethyl)guanine
Conditions | Yield |
---|---|
With dmap Ambient temperature; | 91% |
With dmap In N,N-dimethyl-formamide at 23℃; Acetylation; | 90% |
ganciclovir
tert-butylchlorodiphenylsilane
2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-ethoxymethyl]-1,9-dihydro-purin-6-one
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 24h; Substitution; silylation; | 91% |
trimethyl orthovalerate
ganciclovir
Conditions | Yield |
---|---|
Stage #1: trimethyl orthovalerate; ganciclovir With trifluoroacetic acid In N,N-dimethyl-formamide at 23℃; for 2h; Substitution; Stage #2: With water In N,N-dimethyl-formamide at 23℃; Hydrolysis; | A 90% B 5% |
ganciclovir
azidovaline
2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-1,3-bis-1'-propyl-(2'S)-azido-3'-methylbutanoate
Conditions | Yield |
---|---|
Stage #1: ganciclovir With benzotriazol-1-ol; triethylamine In dimethyl sulfoxide at 25 - 30℃; for 0.166667h; Stage #2: azidovaline In dimethyl sulfoxide at 25 - 30℃; Stage #3: With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 25 - 30℃; for 2h; | 88.8% |
Stage #1: ganciclovir With triethanolamine; benzotriazol-1-ol In dimethyl sulfoxide at 25 - 30℃; Stage #2: azidovaline With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20 - 30℃; |
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide at 23℃; Esterification; | 88% |
With dmap Ambient temperature; | 52% |
ganciclovir
1,1'-carbonyldiimidazole
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 50℃; for 18h; | 87% |
Conditions | Yield |
---|---|
Stage #1: trimethoxypropane; ganciclovir With trifluoroacetic acid In N,N-dimethyl-formamide at 23℃; for 2h; Substitution; Stage #2: With water In N,N-dimethyl-formamide at 23℃; Hydrolysis; | A 87% B 6% |
Conditions | Yield |
---|---|
With dmap Ambient temperature; | 86% |
With dmap In N,N-dimethyl-formamide at 23℃; Esterification; | 80% |
ganciclovir
4-isobutyryloxyphenacyl bromide
isobutyric acid 4-[3-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-8-oxo-5,8-dihydro-3H-1,3,4,5,7a-pentaaza-s-indacen-6-yl]-phenyl ester
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide | 86% |
Stage #1: ganciclovir With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 4-isobutyryloxyphenacyl bromide In N,N-dimethyl-formamide at 20℃; for 4h; Further stages.; | 55% |
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 4h; |
ganciclovir
2,2-dimethylpropanoic anhydride
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide for 48h; Ambient temperature; | 84% |
ganciclovir
N,N-dimethyl-formamide dimethyl acetal
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; for 29h; | 84% |
Conditions | Yield |
---|---|
Stage #1: 1,1,1-trimethoxybutane; ganciclovir With trifluoroacetic acid In N,N-dimethyl-formamide at 23℃; for 2h; Substitution; Stage #2: With water In N,N-dimethyl-formamide at 23℃; Hydrolysis; | A 83% B 15% |
ganciclovir
N-(Benzyloxycarbonyl)glycine
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 48h; Acylation; | 81% |
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide at 23℃; Esterification; | 80% |
ganciclovir
acetic anhydride
9-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine
Conditions | Yield |
---|---|
With pyridine for 6h; Reflux; | 80% |
undecylenic acid
ganciclovir
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 23℃; for 48h; Esterification; | 78% |
benzaldehyde dimethyl acetal
ganciclovir
Conditions | Yield |
---|---|
Stage #1: benzaldehyde dimethyl acetal; ganciclovir With toluene-4-sulfonic acid In dimethyl sulfoxide at 25 - 80℃; Stage #2: With triethylamine In water; dimethyl sulfoxide; ethyl acetate at 25 - 35℃; | 78% |
Isovaleric anhydride
ganciclovir
Conditions | Yield |
---|---|
Stage #1: ganciclovir With pyridine; chloro-trimethyl-silane at 20℃; for 0.25h; Stage #2: Isovaleric anhydride at 20℃; for 3h; Stage #3: With ammonia In water | 76.8% |
N-Acetylimidazole
ganciclovir
9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine
Conditions | Yield |
---|---|
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux; Large scale; Stage #2: N-Acetylimidazole With triethylamine at 20℃; for 6h; Large scale; Stage #3: In methanol at 0 - 20℃; for 2h; Reagent/catalyst; Solvent; Large scale; | 75.7% |
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux; Stage #2: N-Acetylimidazole With triethylamine In toluene at 20℃; for 6h; Stage #3: With methanol In toluene at 0 - 20℃; for 2h; Reagent/catalyst; Solvent; | 75.7% |
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux; Stage #2: N-Acetylimidazole With triethylamine In toluene at 20℃; for 6h; Stage #3: With methanol In toluene at 0 - 20℃; for 2h; Reagent/catalyst; Solvent; | 75.7% |
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux; Stage #2: N-Acetylimidazole With triethylamine In toluene at 20℃; for 6h; Reagent/catalyst; Solvent; | 75.7% |
vinyl acetate
ganciclovir
9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine
Conditions | Yield |
---|---|
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux; Large scale; Stage #2: vinyl acetate With triethylamine at 20℃; for 6h; Large scale; Stage #3: In ethanol at 0 - 20℃; for 3h; Reagent/catalyst; Solvent; Large scale; | 75.2% |
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux; Stage #2: vinyl acetate With triethylamine In 2-methyltetrahydrofuran at 20℃; for 6h; Stage #3: With ethanol In 2-methyltetrahydrofuran at 0 - 20℃; for 2h; Reagent/catalyst; Solvent; | 75.2% |
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux; Stage #2: vinyl acetate With triethylamine In tetrahydrofuran at 20℃; for 6h; Stage #3: With ethanol In tetrahydrofuran at 0 - 20℃; for 3h; Reagent/catalyst; Solvent; | 75.2% |
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux; Stage #2: vinyl acetate With triethylamine In 2-methyltetrahydrofuran at 20℃; for 6h; Reagent/catalyst; Solvent; | 75.2% |
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