Ganciclovir supplier | CasNO.82410-32-0

Name
Ganciclovir
EINECS 627-054-3
CAS No. 82410-32-0
Article Data36
CAS DataBase
Density 1.81 g/cm³
Solubility 0.1 M HCl: 10 mg/mL
Melting Point 250 °C
Formula C₉H₁₃N₅O₄
Boiling Point 675 °C at 760 mmHg
Molecular Weight 255.233
Flash Point 362 °C
Transport Information
Appearance white powder
Safety 53-36/37/39-45
Risk Codes 46-60-61
Molecular Structure
Hazard Symbols T
Synonyms Gancyclovir;
PSA 139.28000
LogP -1.38970

Synthetic route

: 84960-04-3
N2-acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
With ammonium hydroxide In methanol at 20℃; for 17h;	94%
With ammonium hydroxide In methanol at 25℃; for 16h; Yield given;

: 86357-14-4
9-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
With ammonium hydroxide for 72h; Ambient temperature;	91%
With acetic acid In water; methylamine	87%
With potassium hydroxide at 70℃; for 0.5h; Reagent/catalyst; Microwave irradiation;	82.8%
With methanol; potassium hydroxide at 20℃; for 12h;	78%
With acetic acid In methylamine

: 82410-31-9
9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
palladium dichloride In ethanol; cyclohexene for 5h; Heating;	90%
With palladium; cyclohexene In ethanol	87.7%
With cyclohexene; palladium In ethanol for 24h; Heating;	87.7%
With cyclohexene; palladium In ethanol

: 82410-31-9
9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
With ethanol; palladium In cyclohexene for 18h; Heating;	84%

: 100675-29-4
N2-acetyl-9-((1,3-pivaloyloxy-2-propoxy)methyl)guanine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
With sodium methylate In methanol for 40h; Heating;	72%

: 131490-72-7
1-<(1,3-dihydroxy-2-propoxy)methyl>-5-<(thiocarbamoyl)amino>-1H-imidazole-4-carboxamide

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
With sodium hydroxide; copper(II) sulfate for 1h; Heating;	61%

: 1219792-39-8
2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-1,3-bis-1'-propyl-(2'S)-azido-3'-methylbutanoate

A: 1219792-38-7
2-[(2-amino-1,6-dihydro-6-oxopurin-9-yl)methyloxy]-3-hydroxypropyl 2'-(S)-azido-3'-methylbutanoate

B: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In methanol at 20℃; for 14h;	A 34.5% B 20 %Chromat.

: 86629-51-8
C23H21N5O6

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
With ammonia In methanol Yield given;

: 86629-59-6
9-<<2-hydroxy-1-(hydroxymethyl)ethoxy>methyl>-2,6-diamino-purine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
at 25℃; for 18h; adenosine deaminase, pH = 7.5;

: 88110-89-8
9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine

A: 82410-32-0
ganciclovir

B: 64-19-7
acetic acid

Conditions

Conditions	Yield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;

: ganciclovir dipropionate

A: 82410-32-0
ganciclovir

B: 802294-64-0
propionic acid

Conditions

Conditions	Yield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;

: 86357-19-9
9-(1,3-diacetoxy-2-propoxymethyl)guanine

A: 82410-32-0
ganciclovir

B: 64-19-7
acetic acid

Conditions

Conditions	Yield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;

: 88110-71-8
ganciclovir dibutyrate

A: 82410-32-0
ganciclovir

B: 107-92-6
butyric acid

Conditions

Conditions	Yield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;

: 194159-18-7
ganciclovir monopropionate

A: 82410-32-0
ganciclovir

B: 802294-64-0
propionic acid

Conditions

Conditions	Yield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;

: ganciclovir diisobutyrate

A: 82410-32-0
ganciclovir

B: 79-31-2
isobutyric Acid

Conditions

Conditions	Yield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;

: 298197-24-7
ganciclovir monobutyrate

A: 82410-32-0
ganciclovir

B: 107-92-6
butyric acid

Conditions

Conditions	Yield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;

: ganciclovir monovalerate

A: 82410-32-0
ganciclovir

B: 109-52-4
valeric acid

Conditions

Conditions	Yield
With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents;

: 73-40-5
2-amino-1,9-dihydro-6H-purin-6-one

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (NH4)2SO4 2: Bu4NF / tetrahydrofuran 3: cyclohexene / Pd / ethanol View Scheme
Multi-step reaction with 3 steps 1: ammonium sulfate / 96 h / Heating 2: 17.8 percent / tetrabutylammonium fluoride / tetrahydrofuran / 22 h / Heating 3: 87.7 percent / cyclohexene / palladium black / ethanol / 24 h / Heating View Scheme
Multi-step reaction with 3 steps 1: (NH4)2SO4 2: Bu4NF / tetrahydrofuran 3: 87.7 percent / Pd black; cyclohexene / ethanol View Scheme

: 18602-85-2
2,6,9-tris(trimethylsilyl)guanine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Bu4NF / tetrahydrofuran 2: cyclohexene / Pd / ethanol View Scheme
Multi-step reaction with 2 steps 1: 17.8 percent / tetrabutylammonium fluoride / tetrahydrofuran / 22 h / Heating 2: 87.7 percent / cyclohexene / palladium black / ethanol / 24 h / Heating View Scheme
Multi-step reaction with 2 steps 1: Bu4NF / tetrahydrofuran 2: 87.7 percent / Pd black; cyclohexene / ethanol View Scheme

: 82410-30-8
N2-acetyl-9-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / EtOH / Pd(OH)2/C / cyclohexane / 40 h / Heating 2: 94 percent / aq. ammonium hydroxide / methanol / 17 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: 20percent Pd(OH)2/C / cyclohexene; ethanol / 32 h / Heating 2: 56percent NH4OH / methanol / 16 h / 25 °C View Scheme
Multi-step reaction with 2 steps 1: 99 percent / conc. ammonium hydroxide, pyridine / 15 h / 55 °C 2: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating View Scheme

: 3056-33-5
2,9-diacetylguanine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 31 percent / p-toluenesulfonic acid / tetrahydrothiophene 1,1-dioxide / 85 h / 95 °C 2: 90 percent / EtOH / Pd(OH)2/C / cyclohexane / 40 h / Heating 3: 94 percent / aq. ammonium hydroxide / methanol / 17 h / 20 °C View Scheme

: 86357-17-7
7-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 50 percent / 0.17 h / 230 °C 2: 91 percent / NH4OH / 72 h / Ambient temperature View Scheme

: 19962-37-9
N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) HMDS, ammonium sulfate; 2.) TBAI; 3.)methanol, water 2: 99 percent / conc. ammonium hydroxide, pyridine / 15 h / 55 °C 3: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating View Scheme
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C 2: palladium diacetate; bis(tertbutylcarbonyloxy)iodobenzene / toluene / 24 h / 120 °C 3: methanol; potassium hydroxide / 12 h / 20 °C View Scheme

: 34097-37-5
2,6-bisacetamidopurine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 5.4 g / triethylamine / dimethylformamide / 1.) r.t. 60 h; 2.) 40 deg C, 1 h 2: 85 percent / Na / methanol / 1.) reflux, 2 h; 2.) r.t. 12 h 3: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating 4: 18 h / 25 °C / adenosine deaminase, pH = 7.5 View Scheme

: 89419-14-7
9-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-9H-purine-2,6-diamine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating 2: 18 h / 25 °C / adenosine deaminase, pH = 7.5 View Scheme

: 89419-13-6
N-[2-Acetylamino-9-(2-benzyloxy-1-benzyloxymethyl-ethoxymethyl)-9H-purin-6-yl]-acetamide

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 85 percent / Na / methanol / 1.) reflux, 2 h; 2.) r.t. 12 h 2: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating 3: 18 h / 25 °C / adenosine deaminase, pH = 7.5 View Scheme

: 84222-47-9
9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>-methyl>-6-chloroguanine

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 70 percent / sodium, mercaptoethanol, water / methanol / 2.5 h / Heating 2: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating View Scheme

: 10310-21-1
2-Amino-6-chloropurin

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) 1,1,1,3,3,3-hexamethyldisilazane, ammonium sulfate; 2.) mercuric cyanide / 1.) 2 h, reflux; 2.) benzene, 3 h, reflux 2: 70 percent / sodium, mercaptoethanol, water / methanol / 2.5 h / Heating 3: 84 percent / ethanol / palladium black / cyclohexene / 18 h / Heating View Scheme

: 131490-62-5
5-amino-1-<(1,3-dihydroxy-2-propoxy)methyl>-1H-imidazole-4-carboxamide

: 82410-32-0
ganciclovir

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2) K2CO3 / 1) acetone, reflux, 1 h, 2) methanol, reflux, 4 h 2: 61 percent / 3N aq. NaOH, copper(II) sulfate / 1 h / Heating View Scheme

: 82410-32-0
ganciclovir

: 97-72-3
2-Methylpropionic anhydride

: isobutyric acid 2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-isobutyryloxy-propyl ester

Conditions

Conditions	Yield
With pyridine; dmap for 1h; Acylation; Heating;	99%

: 82410-32-0
ganciclovir

: 57-10-3
1-hexadecylcarboxylic acid

: Hexadecanoic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-hexadecanoyloxy-propyl ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 50℃; for 50h;	97%

: tert-butoxyphosphonic acid dichloride

: 82410-32-0
ganciclovir

: C13H22N5O7P

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 50℃; for 5h; Inert atmosphere;	96.8%

: 82410-32-0
ganciclovir

: 18162-48-6
tert-butyldimethylsilyl chloride

: 109082-88-4
9-<(1,3-bis(tert-butyldimethylsilyloxy)-2-propoxy)methyl>guanine

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide for 1h; Ambient temperature;	95%

: 82410-32-0
ganciclovir

: C9H11Cl2N5O2

Conditions

Conditions	Yield
With phosphorus pentachloride In tetrahydrofuran at 0 - 10℃; for 1h;	92.7%

: 82410-32-0
ganciclovir

: 108-24-7
acetic anhydride

: 86357-19-9
9-(1,3-diacetoxy-2-propoxymethyl)guanine

Conditions

Conditions	Yield
With dmap Ambient temperature;	91%
With dmap In N,N-dimethyl-formamide at 23℃; Acetylation;	90%

: 82410-32-0
ganciclovir

: 58479-61-1
tert-butylchlorodiphenylsilane

: 266684-38-2
2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-ethoxymethyl]-1,9-dihydro-purin-6-one

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 24h; Substitution; silylation;	91%

: 13820-09-2
trimethyl orthovalerate

: 82410-32-0
ganciclovir

A: ganciclovir monovalerate

B: pentanoic acid 3-hydroxy-2-(6-oxo-2-pentanoylamino-1,6-dihydro-purin-9-ylmethoxy)-propyl ester

Conditions

Conditions	Yield
Stage #1: trimethyl orthovalerate; ganciclovir With trifluoroacetic acid In N,N-dimethyl-formamide at 23℃; for 2h; Substitution; Stage #2: With water In N,N-dimethyl-formamide at 23℃; Hydrolysis;	A 90% B 5%

...Expand

: 82410-32-0
ganciclovir

: 40224-47-3
azidovaline

: 1219792-39-8
2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-1,3-bis-1'-propyl-(2'S)-azido-3'-methylbutanoate

Conditions

Conditions	Yield
Stage #1: ganciclovir With benzotriazol-1-ol; triethylamine In dimethyl sulfoxide at 25 - 30℃; for 0.166667h; Stage #2: azidovaline In dimethyl sulfoxide at 25 - 30℃; Stage #3: With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 25 - 30℃; for 2h;	88.8%
Stage #1: ganciclovir With triethanolamine; benzotriazol-1-ol In dimethyl sulfoxide at 25 - 30℃; Stage #2: azidovaline With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20 - 30℃;

: 82410-32-0
ganciclovir

: 123-62-6
propionic acid anhydride

: ganciclovir dipropionate

Conditions

Conditions	Yield
With dmap In N,N-dimethyl-formamide at 23℃; Esterification;	88%
With dmap Ambient temperature;	52%

: 82410-32-0
ganciclovir

: 530-62-1
1,1'-carbonyldiimidazole

: 9-<(1,3-di(imidazol-1-ylcarbonyloxy)-2-propoxy)methyl>guanine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; for 18h;	87%

: 24823-81-2
trimethoxypropane

: 82410-32-0
ganciclovir

A: 194159-18-7
ganciclovir monopropionate

B: propionic acid 3-hydroxy-2-(6-oxo-2-propionylamino-1,6-dihydro-purin-9-ylmethoxy)-propyl ester

Conditions

Conditions	Yield
Stage #1: trimethoxypropane; ganciclovir With trifluoroacetic acid In N,N-dimethyl-formamide at 23℃; for 2h; Substitution; Stage #2: With water In N,N-dimethyl-formamide at 23℃; Hydrolysis;	A 87% B 6%

...Expand

: 106-31-0
butanoic acid anhydride

: 82410-32-0
ganciclovir

: 88110-71-8
ganciclovir dibutyrate

Conditions

Conditions	Yield
With dmap Ambient temperature;	86%
With dmap In N,N-dimethyl-formamide at 23℃; Esterification;	80%

: 82410-32-0
ganciclovir

: 476360-57-3
4-isobutyryloxyphenacyl bromide

: 476360-70-0
isobutyric acid 4-[3-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-8-oxo-5,8-dihydro-3H-1,3,4,5,7a-pentaaza-s-indacen-6-yl]-phenyl ester

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide	86%
Stage #1: ganciclovir With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 4-isobutyryloxyphenacyl bromide In N,N-dimethyl-formamide at 20℃; for 4h; Further stages.;	55%
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 4h;

: 82410-32-0
ganciclovir

: 1538-75-6
2,2-dimethylpropanoic anhydride

: 9-<(1,3-dipivaloyloxy-2-propoxy)methyl>guanine

Conditions

Conditions	Yield
With dmap In N,N-dimethyl-formamide for 48h; Ambient temperature;	84%

: 82410-32-0
ganciclovir

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: N'-(9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylmethanimidamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 29h;	84%

: 43083-12-1
1,1,1-trimethoxybutane

: 82410-32-0
ganciclovir

A: 298197-24-7
ganciclovir monobutyrate

B: butyric acid 2-(2-butyrylamino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-hydroxy-propyl ester

Conditions

Conditions	Yield
Stage #1: 1,1,1-trimethoxybutane; ganciclovir With trifluoroacetic acid In N,N-dimethyl-formamide at 23℃; for 2h; Substitution; Stage #2: With water In N,N-dimethyl-formamide at 23℃; Hydrolysis;	A 83% B 15%

...Expand

: 82410-32-0
ganciclovir

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: Benzyloxycarbonylamino-acetic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(2-benzyloxycarbonylamino-acetoxy)-propyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 48h; Acylation;	81%

: 82410-32-0
ganciclovir

: 97-72-3
2-Methylpropionic anhydride

: ganciclovir diisobutyrate

Conditions

Conditions	Yield
With dmap In N,N-dimethyl-formamide at 23℃; Esterification;	80%

: 82410-32-0
ganciclovir

: 108-24-7
acetic anhydride

: 86357-14-4
9-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine

Conditions

Conditions	Yield
With pyridine for 6h; Reflux;	80%

: 112-37-8
undecylenic acid

: 82410-32-0
ganciclovir

: undecanoic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-undecanoyloxy-propyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 23℃; for 48h; Esterification;	78%

: 1125-88-8
benzaldehyde dimethyl acetal

: 82410-32-0
ganciclovir

: 2-amino-9-((2-phenyl-1,3-dioxan-5-yloxy)methyl)-1H-purin-6(9H)-one

Conditions

Conditions	Yield
Stage #1: benzaldehyde dimethyl acetal; ganciclovir With toluene-4-sulfonic acid In dimethyl sulfoxide at 25 - 80℃; Stage #2: With triethylamine In water; dimethyl sulfoxide; ethyl acetate at 25 - 35℃;	78%

: 1468-39-9
Isovaleric anhydride

: 82410-32-0
ganciclovir

: 2-N-isobutyryl-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}guanine

Conditions

Conditions	Yield
Stage #1: ganciclovir With pyridine; chloro-trimethyl-silane at 20℃; for 0.25h; Stage #2: Isovaleric anhydride at 20℃; for 3h; Stage #3: With ammonia In water	76.8%

: 2466-76-4
N-Acetylimidazole

: 82410-32-0
ganciclovir

: 88110-89-8
9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine

Conditions

Conditions	Yield
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux; Large scale; Stage #2: N-Acetylimidazole With triethylamine at 20℃; for 6h; Large scale; Stage #3: In methanol at 0 - 20℃; for 2h; Reagent/catalyst; Solvent; Large scale;	75.7%
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux; Stage #2: N-Acetylimidazole With triethylamine In toluene at 20℃; for 6h; Stage #3: With methanol In toluene at 0 - 20℃; for 2h; Reagent/catalyst; Solvent;	75.7%
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux; Stage #2: N-Acetylimidazole With triethylamine In toluene at 20℃; for 6h; Stage #3: With methanol In toluene at 0 - 20℃; for 2h; Reagent/catalyst; Solvent;	75.7%
Stage #1: ganciclovir With Trimethyl borate In toluene for 5h; Reflux; Stage #2: N-Acetylimidazole With triethylamine In toluene at 20℃; for 6h; Reagent/catalyst; Solvent;	75.7%

: 108-05-4
vinyl acetate

: 82410-32-0
ganciclovir

: 88110-89-8
9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine

Conditions

Conditions	Yield
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux; Large scale; Stage #2: vinyl acetate With triethylamine at 20℃; for 6h; Large scale; Stage #3: In ethanol at 0 - 20℃; for 3h; Reagent/catalyst; Solvent; Large scale;	75.2%
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux; Stage #2: vinyl acetate With triethylamine In 2-methyltetrahydrofuran at 20℃; for 6h; Stage #3: With ethanol In 2-methyltetrahydrofuran at 0 - 20℃; for 2h; Reagent/catalyst; Solvent;	75.2%
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux; Stage #2: vinyl acetate With triethylamine In tetrahydrofuran at 20℃; for 6h; Stage #3: With ethanol In tetrahydrofuran at 0 - 20℃; for 3h; Reagent/catalyst; Solvent;	75.2%
Stage #1: ganciclovir With triethyl borate In 2-methyltetrahydrofuran for 3h; Reflux; Stage #2: vinyl acetate With triethylamine In 2-methyltetrahydrofuran at 20℃; for 6h; Reagent/catalyst; Solvent;	75.2%

Ganciclovir Specification

1. Introduction of Ganciclovir

Ganciclovir, with the IUPAC Name of 2-Amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one, is one kind of white powder. This chemical has the Classification Code which include Anti-Infective Agents; Antiviral; Antiviral agents; Drug / Therapeutic Agent; Mutation data. Besides, it belongs to the Product Categories which include Bases & Related Reagents; Intermediates & Fine Chemicals; Nucleotides; Pharmaceuticals; API's; Antiviral.

2. Properties of Ganciclovir

Ganciclovir has the following properties: (1)Index of Refraction: 1.76; (2)Molar Refractivity: 57.9 cm³; (3)Molar Volume: 140.5 cm³; (4)Polarizability: 22.95×10-24 cm³; (5)Surface Tension: 86.6 dyne/cm; (6)Density: 1.81 g/cm³; (7)Flash Point: 362 °C; (8)Enthalpy of Vaporization: 104.13 kJ/mol; (9)Boiling Point: 675 °C at 760 mmHg; (10)Melting Point: 250 °C; (11)storage temperature: 2-8 °C; (12)solubility: 0.1 M HCl: 10 mg/mL; (13)Vapour Pressure: 3.82E-19 mmHg at 25 °C.

3. Structure Descriptors of Ganciclovir

You could convert the following datas into the molecular structure:
(1).Canonical SMILES: c12c(ncn1COC(CO)CO)c([nH]c(n2)N)=O
(2).InChI: InChI=1/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)

4. Toxicity of Ganciclovir

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	intravenous	> 150mg/kg (150mg/kg)	Drugs in Japan Vol. -, Pg. 291, 1990.
dog	LD50	oral	> 1gm/kg (1000mg/kg)	Drugs in Japan Vol. -, Pg. 291, 1990.
mouse	LD50	intraperitoneal	1gm/kg (1000mg/kg)	Journal of Medicinal Chemistry. Vol. 26, Pg. 759, 1983.
mouse	LD50	intravenous	900mg/kg (900mg/kg)	Drugs in Japan Vol. -, Pg. 291, 1990.
mouse	LD50	oral	> 2gm/kg (2000mg/kg)	Drugs in Japan Vol. -, Pg. 291, 1990.

5. Safety Information of Ganciclovir

Common adverse drug reactions >=1% of patients) include: neutropenia, granulocytopenia, thrombocytopenia, fever, nausea, vomiting, dyspepsia, diarrhoea, abdominal pain, flatulence, anorexia, raised liver enzymes, headache, confusion, hallucination, anaemia, pain and phlebitis at injection site (due to high pH), sweating, rash.
Hazard Codes: Toxic T
Risk Statements: 46-60-61
R46:May cause heritable genetic damage.
R60:May impair fertility.
R61:May cause harm to the unborn child.
Safety Statements: 53-36/37/39-45
S53:Avoid exposure - obtain special instructions before use.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS of Ganciclovir (CAS NO.82410-32-0): MF8407000

6. Use of Ganciclovir

Ganciclovir (CAS NO.82410-32-0) is an antiviral medication used to treat or prevent cytomegalovirus (CMV) infections.

Product Name

Ganciclovir

Synthetic route

Ganciclovir Specification

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