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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Piperine Manufacturer/High quality/Best price/In stock

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Greenutra Resource Inc

Black Pepper Extract [Product Name]Black pepper extract [Botanical Name] Piper Nigrum L. [Part Used] Seed [Active Ingredients] Piperine [CAS No.] 94-62-2 [Molecular Formula] C17H19NO3 [Molecular Weight] 285.34 [Specfication]90%-

Black Pepper Extract

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $17.0

Type:Trading Company

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Lonwin Chemical Group Limited

Why Choose Us 1. Quality Price We are the manufacturer, so we can provide the competitive price and high quality product. 2. Packing Products could be packaged according to customer's specializedrequirements. 3. Transport The products can be tr

Naturel Black Pepper Extract piperine 95 powder cas 94-62-2

Cas:94-62-2

Min.Order:1000 Kilogram

FOB Price: $70.0 / 75.0

Type:Other

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SHENGZHIKAI TECHNOLOGY INDUSTRY CO., LTD

1. The product quality has passed the professional production process and quality inspection, and the purity is more than 99%; We have a professional RESEARCH and development team and strong technical force to ensure technical support and research ca

Hot Selling Black Pepper Extract Piperine Extract Pure Piperine 90% 95% 98% cas 94-62-2

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $70.0 / 150.0

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Light yellow to 0ff white powder Complies Odor Characte

High purity Piperine with high quality and best price cas:94-62-2

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $600.0 / 700.0

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Piperine supplier in China

Cas:94-62-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Superiority KONO is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in

Hot Sale Best Quality Piperine CAS 94-62-2

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

94-62-2Black Pepper extract Piperine 98% CAS NO.94-62-2

Cas:94-62-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Xi'an Quanao Biotech Co., Ltd.

Professional Factory We has a complete production and operating system, with an annual output capacity of 2000 tons. It can produce variety of content and proportion of extract according to the demand . Excellent Team We are a young and profess

Best Piperine 95% from Black pepper extract lowest price Piperine 50% 98%

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $199.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Piperine

Cas:94-62-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Piperine 94-62-2 ISO Producer

Cas:94-62-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Xi`an Eastling Biotech Co., Ltd.

Piperine CAS: 94-62-2 Molecular Formula: C17H19NO3 Home Product Category Essence and spice Natural flavor 94-62-2 94-62-2 - Names and Identifiers Name Piperine Synonyms PIPERINE Piperine FEMA 2909 Bioperin

Top Quality Natural Piperine

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $35.0 / 49.0

Type:Lab/Research institutions

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Piperine

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Black Pepper Extract

Cas:94-62-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Piperine

Cas:94-62-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name: Piperine Alias: 1-Piperylpiperidine English Name:Piperine CSA: 94-62-2 Molecular formula: C17H19NO3 Molecular weight: 285.3377 Packaging Specification: 25kg/drum high purity 99%min stock Hubei DiBo Chemical Co., Ltd. was founded in 2

Piperine/CAS:94-62-2/Manufacturer provides straightly

Cas:94-62-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Piperine Basic information Product Name: Piperine Synonyms: PIPERINE;N-PIPEROYLPIPERIDIN;(E,E)-1-[5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-piperidine;FEMA 2909;5-BENZO[1,3]DIOXOL-

Piperine_

Cas:94-62-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Density: 1.0864 (rough estimate) Melting point: 131-135 ° C (lit.) Boiling point: 427.77 ° C (rough estimate) Flash point: 255.298 ° C Water solubility: 40 mg/L (18 º C) Steam pressure: 0mmHg at 25 ° C Solubility: 0.04g/l Refract

Piperine 94-62-2

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 94-62-2 with best quality

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Piperine CAS NO.94-62-2 CAS NO.94-62-2

Cas:94-62-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Piperine/ LIDE PHARMA- Factory supply / Best price

Cas:94-62-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:Off-white to tan or yellow-tan powder Storage:room temperature Package:25kg/drum Application:The alkaloid which gives pepper its spiciness, and has been used as an organic insecticide. Transportation:Express/Sea/Air Port:any port in chin

Piperine factory price

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr

Pure Natural 95% Piperine Powder CAS 94-62-2

Cas:94-62-2

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Piperine 94-62-2

Cas:94-62-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At pres

Piperine with CAS:94-62-2

Cas:94-62-2

Min.Order:1 Kilogram

FOB Price: $520.0 / 540.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Piperine CAS: 94-62-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, ste

Piperine CAS: 94-62-2

Cas:94-62-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Piperine

Cas:94-62-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Piperine

Cas:94-62-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

Black Pepper Extract 95% Piperine

Cas:94-62-2

Min.Order:25 Kilogram

FOB Price: $450.0 / 500.0

Type:Lab/Research institutions

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Synthetic route

1-crotonoylpiperidine
50838-22-7

1-crotonoylpiperidine

piperonal
120-57-0

piperonal

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
With Aliquat 336; potassium carbonate In toluene at 90℃; for 10h;95%
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dimethyl sulfoxide 1) 15 min, 25 deg C 2) 2 h, 60-65 deg C;88%
Stage #1: piperonal With sodium hydroxide In water; dimethyl sulfoxide for 0.5h;
Stage #2: 1-crotonoylpiperidine In water; dimethyl sulfoxide at 20℃;
75.3%
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dimethyl sulfoxide at 60 - 65℃; for 2h; Product distribution; various solvents;
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water; dimethyl sulfoxide at 25 - 30℃;89 g
piperidine
110-89-4

piperidine

piperic acid
136-72-1

piperic acid

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Stage #1: piperic acid With thionyl chloride In dichloromethane at 20℃; Schlenk technique;
Stage #2: piperidine In dichloromethane at 20℃; for 1h; Schlenk technique; Inert atmosphere; stereoselective reaction;
95%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 8h;93%
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; triethylamine In dichloromethane at 20 - 25℃; for 1h;90%
With dmap; dicyclohexyl-carbodiimide Amidation;72%
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 18h; Inert atmosphere;71%
piperidine
110-89-4

piperidine

Bestmann ylide
73818-55-0, 15596-07-3

Bestmann ylide

(E)-3,4-methylenedioxycinnamaldehyde
58095-77-5, 14756-00-4

(E)-3,4-methylenedioxycinnamaldehyde

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
In tetrahydrofuran for 24h; Heating;90%
piperidine
110-89-4

piperidine

(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienamide

(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienamide

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
With dipotassium peroxodisulfate In water at 100℃; for 0.166667h; Microwave irradiation; Green chemistry;83%
1-[(E)-3,4-(methylenedioxy)cinnamylsulfonyl]acetyl-piperidine
736947-76-5

1-[(E)-3,4-(methylenedioxy)cinnamylsulfonyl]acetyl-piperidine

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
With aluminum oxide; potassium hydroxide; dibromodifluoromethane In dichloromethane at 20℃; for 1h;82%
N-acrylpiperidine
10043-37-5

N-acrylpiperidine

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Stage #1: 3,4-methylenedioxy-trans-cinnamic acid With N-Bromosuccinimide; tetrabutylammonium trifluoroacetate In 1,2-dichloro-ethane at 20℃; for 4h; Decarboxylation; bromination; Hunsdiecker reaction;
Stage #2: N-acrylpiperidine With palladium diacetate; triphenylantimony; triethylamine In 1,2-dichloro-ethane for 20h; Heck reaction;
51%
N-acrylpiperidine
10043-37-5

N-acrylpiperidine

(E)-β-iodo-3,4-methylenedioxystyrene
202998-56-9

(E)-β-iodo-3,4-methylenedioxystyrene

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
With palladium diacetate; triethylamine; triphenylphosphine; lithium chloride In acetonitrile at 70 - 80℃; for 18h;38%
(E)-5-(3-bromoprop-1-en-1-yl)benzo[d][1,3]dioxole
67911-75-5

(E)-5-(3-bromoprop-1-en-1-yl)benzo[d][1,3]dioxole

N-<1-oxo-2-(3,6-diisopropyl-2-pyrazinylsulfinyl)ethyl>piperidine
136055-33-9

N-<1-oxo-2-(3,6-diisopropyl-2-pyrazinylsulfinyl)ethyl>piperidine

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
With potassium diisopropylamide 1.) THF, hexane, RT, 1 h, 2.) THF, hexane, reflux; Yield given. Multistep reaction;
1'-hydroxysafrole
5208-87-7

1'-hydroxysafrole

1-p-Tolylsulfanylethynyl-piperidine
80880-59-7

1-p-Tolylsulfanylethynyl-piperidine

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
1.) BF3OEt2 in refluxing toluene; 2.) oxidation (m-chloroperbenzoic acid, CH2Cl2,-78 grad C); 3.) reflux in toluene; Yield given. Multistep reaction;
Acetic acid 1-(benzenesulfonyl-benzo[1,3]dioxol-5-yl-methyl)-4-oxo-4-piperidin-1-yl-butyl ester
104683-09-2

Acetic acid 1-(benzenesulfonyl-benzo[1,3]dioxol-5-yl-methyl)-4-oxo-4-piperidin-1-yl-butyl ester

A

piperine
94-62-2

piperine

B

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol for 12h; Ambient temperature; Yield given. Yields of byproduct given;
piperidine
110-89-4

piperidine

piperic acid chloride
4711-72-2

piperic acid chloride

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
In diethyl ether
In diethyl ether 1.) -60 deg C to 10 deg C, 2.) 10 deg C, 1 h; Yield given;
In tetrahydrofuran at 20℃;
In dichloromethane at 60℃;
piperidine
110-89-4

piperidine

chavicinoyl chloride

chavicinoyl chloride

Piperine
94-62-2

Piperine

piperidine
110-89-4

piperidine

piperinic acid chloride

piperinic acid chloride

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
With benzene
piperidine
110-89-4

piperidine

trityl thiosemicarbazide resin

trityl thiosemicarbazide resin

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 100 percent / acetone / 20 °C
2.1: KOH / methanol / 0.17 h / 0 °C
2.2: 85 percent / methanol / 1 h / 0 °C
3.1: 92 percent / oxone / methanol; H2O / 0 °C
4.1: 82 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
thioacetic acid S-(3-benzo[1,3]dioxol-5-yl-allyl) ester
736947-15-2

thioacetic acid S-(3-benzo[1,3]dioxol-5-yl-allyl) ester

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: KOH / methanol / 0.17 h / 0 °C
1.2: 85 percent / methanol / 1 h / 0 °C
2.1: 92 percent / oxone / methanol; H2O / 0 °C
3.1: 82 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
1-[(E)-3,4-(methylenedioxy)cinnamylthio]acetyl-piperidine
736947-38-9

1-[(E)-3,4-(methylenedioxy)cinnamylthio]acetyl-piperidine

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / oxone / methanol; H2O / 0 °C
2: 82 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
1-chloroacetyl-piperidine
1440-60-4

1-chloroacetyl-piperidine

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: KOH / methanol / 0.17 h / 0 °C
1.2: 85 percent / methanol / 1 h / 0 °C
2.1: 92 percent / oxone / methanol; H2O / 0 °C
3.1: 82 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
piperonal
120-57-0

piperonal

rhodaninoic acid

rhodaninoic acid

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: benzene / 4 h / Heating
2.1: LiAlH4; AlCl3 / tetrahydrofuran / 1 h / 0 °C
3.1: 83 percent / DIAD; Ph3P / benzene / 1 h / 20 °C
4.1: KOH / methanol / 0.17 h / 0 °C
4.2: 85 percent / methanol / 1 h / 0 °C
5.1: 92 percent / oxone / methanol; H2O / 0 °C
6.1: 82 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
(E)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-ol
58095-76-4

(E)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-ol

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 83 percent / DIAD; Ph3P / benzene / 1 h / 20 °C
2.1: KOH / methanol / 0.17 h / 0 °C
2.2: 85 percent / methanol / 1 h / 0 °C
3.1: 92 percent / oxone / methanol; H2O / 0 °C
4.1: 82 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 55 percent / PDC / CH2Cl2 / 20 °C
2: 90 percent / tetrahydrofuran / 24 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: PBr3 / CH2Cl2 / 0.5 h / -5 °C
2: 1.) potassium diisopropylamide (KDA) / 1.) THF, hexane, RT, 1 h, 2.) THF, hexane, reflux
View Scheme
ethyl (E)-3-(benzo[d][1,3]dioxol-5-yl)acrylate
24393-66-6

ethyl (E)-3-(benzo[d][1,3]dioxol-5-yl)acrylate

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: LiAlH4; AlCl3 / tetrahydrofuran / 1 h / 0 °C
2.1: 83 percent / DIAD; Ph3P / benzene / 1 h / 20 °C
3.1: KOH / methanol / 0.17 h / 0 °C
3.2: 85 percent / methanol / 1 h / 0 °C
4.1: 92 percent / oxone / methanol; H2O / 0 °C
5.1: 82 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
piperonal
120-57-0

piperonal

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 94 percent / benzene / 24 h / Heating
2: 87 percent / DIBAL-H / tetrahydrofuran; hexane / 6 h / -10 - 20 °C
3: 55 percent / PDC / CH2Cl2 / 20 °C
4: 90 percent / tetrahydrofuran / 24 h / Heating
View Scheme
Multi-step reaction with 4 steps
2: 1) alkali, 2) acid
3: oxalyl chloride / benzene
4: diethyl ether
View Scheme
Multi-step reaction with 2 steps
1: 71 percent
2: 1.) BF3OEt2 in refluxing toluene; 2.) oxidation (m-chloroperbenzoic acid, CH2Cl2,-78 grad C); 3.) reflux in toluene
View Scheme
Multi-step reaction with 3 steps
1: lithium hydroxide / tetrahydrofuran / 4 h / Reflux
2: sodium hydroxide / methanol / 8 h / 20 °C
3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8 h / 20 °C
View Scheme
isosafrole
120-58-1

isosafrole

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 65 percent / SeO2 / dioxane / 16 h / Heating
2: 90 percent / tetrahydrofuran / 24 h / Heating
View Scheme
methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate
40918-96-5

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 87 percent / DIBAL-H / tetrahydrofuran; hexane / 6 h / -10 - 20 °C
2: 55 percent / PDC / CH2Cl2 / 20 °C
3: 90 percent / tetrahydrofuran / 24 h / Heating
View Scheme
piperidine
110-89-4

piperidine

3.) methyl halide

3.) methyl halide

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Et3N; hydroquinone / benzene / 5 h / 20 °C
2.1: N-bromosuccinimide; tetrabutylammonium trifluoroacetate / 1,2-dichloro-ethane / 4 h / 20 °C
2.2: 51 percent / Pd(OAc)2; Ph3Sb; Et3N / 1,2-dichloro-ethane / 20 h
View Scheme
furfural
98-01-1

furfural

ArgoGel-Rink resin bound NH2COCH2NH2

ArgoGel-Rink resin bound NH2COCH2NH2

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: methanol / 15 h / 20 °C
2: 80 percent / tetrahydrofuran / 2 h / 20 °C
3: 75 percent / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol
4: 72 percent / DCC; DMAP
View Scheme
furfural tosylhydrazone
18708-18-4

furfural tosylhydrazone

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / tetrahydrofuran / 2 h / 20 °C
2: 75 percent / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol
3: 72 percent / DCC; DMAP
View Scheme
(2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienal
54976-52-2, 83047-59-0

(2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienal

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / NaClO2; NaH2PO4 / 2-methyl-propan-2-ol
2: 72 percent / DCC; DMAP
View Scheme
3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 73 percent / N-iodosuccinimide, tetrabutylammonium trifluoroacetate / 1,2-dichloro-ethane / Ambient temperature
2: 38 percent / palladium acetate, triphenylphosphine, lithium chloride, triethylamine / acetonitrile / 18 h / 70 - 80 °C
View Scheme
piperic acid
136-72-1

piperic acid

Piperine
94-62-2

Piperine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (COCl)2 / CH2Cl2 / 3 h / Ambient temperature
2: diethyl ether / 1.) -60 deg C to 10 deg C, 2.) 10 deg C, 1 h
View Scheme
Multi-step reaction with 2 steps
1: oxalyl chloride / benzene
2: diethyl ether
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride / dichloromethane / 2 h / Inert atmosphere; Cooling with ice
2: dichloromethane / 60 °C
View Scheme
Piperine
94-62-2

Piperine

tetrahydropiperine
23434-88-0

tetrahydropiperine

Conditions
ConditionsYield
With zinc copper In methanol for 3h; Heating;98%
With 5% Pd/C; hydrogen under 2068.65 Torr; for 4h;98.5%
With 5% Pd(II)/C(eggshell); hydrogen In dichloromethane for 12h;97%
Piperine
94-62-2

Piperine

piperic acid
136-72-1

piperic acid

Conditions
ConditionsYield
With water; potassium hydroxide In ethanol for 18h; Reflux;96.4%
With potassium hydroxide In methanol at 150℃; for 24h;94%
Stage #1: Piperine With potassium hydroxide In ethanol for 20h; Reflux;
Stage #2: With hydrogenchloride In water pH=3;
94.5%
Piperine
94-62-2

Piperine

(E)-5-(benzo[1,3]dioxol-5-yl)-1-(piperidin-1-yl)pent-3-en-1-one
23512-55-2

(E)-5-(benzo[1,3]dioxol-5-yl)-1-(piperidin-1-yl)pent-3-en-1-one

Conditions
ConditionsYield
With methanol; magnesium at 20℃; for 2h; Reduction;96%
With methanol; magnesium at 20℃; for 2h;95%
Piperine
94-62-2

Piperine

A

(E)-5-(benzo[1,3]dioxol-5-yl)-1-(piperidin-1-yl)pent-3-en-1-one
23512-55-2

(E)-5-(benzo[1,3]dioxol-5-yl)-1-(piperidin-1-yl)pent-3-en-1-one

B

cis-5-benzo[1,3]dioxol-5-yl-1-piperidin-1-yl-pent-3-en-1-one

cis-5-benzo[1,3]dioxol-5-yl-1-piperidin-1-yl-pent-3-en-1-one

Conditions
ConditionsYield
With acetic acid; zinc for 2h; Ambient temperature;A 95%
B n/a
With ethylene dibromide; sodium iodide; (2,2'-bipyridine)nickel(II) dibromide In water; N,N-dimethyl-formamide Electrochemical reaction;A 80 % Chromat.
B 20 % Chromat.
Piperine
94-62-2

Piperine

(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)-2,4-pentadien-1-thione
1313741-02-4

(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)-2,4-pentadien-1-thione

Conditions
ConditionsYield
With Lawessons reagent In tetrahydrofuran at 20℃; for 20h;85%
Piperine
94-62-2

Piperine

chabamide

chabamide

Conditions
ConditionsYield
With silica gel In neat (no solvent, solid phase) at 200℃; for 3h; Reagent/catalyst; Solvent; Temperature; Time; Diels-Alder Cycloaddition; regioselective reaction;82%
Piperine
94-62-2

Piperine

(E)-3-[(1S,2S,5R,6S)-5,6-Bis-benzo[1,3]dioxol-5-yl-2-(piperidine-1-carbonyl)-cyclohex-3-enyl]-1-piperidin-1-yl-propenone

(E)-3-[(1S,2S,5R,6S)-5,6-Bis-benzo[1,3]dioxol-5-yl-2-(piperidine-1-carbonyl)-cyclohex-3-enyl]-1-piperidin-1-yl-propenone

nigramide B

nigramide B

chabamide

chabamide

(E)-3-(2,6-bis(benzo[d][1,3]dioxol-5-yl)-5-(piperidine-1-carbonyl)cyclohex-3-en-1-yl)-1-(piperidin-1-yl)prop-2-en-1-one

(E)-3-(2,6-bis(benzo[d][1,3]dioxol-5-yl)-5-(piperidine-1-carbonyl)cyclohex-3-en-1-yl)-1-(piperidin-1-yl)prop-2-en-1-one

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; rac-3-octanol; cobalt(II) chloride at 170℃; for 72h; Diels-Alder reaction; Further byproducts given;A 2%
B 12%
C 81%
D 4%
Piperine
94-62-2

Piperine

(3E,5E)-6-(benzo[d][1,3]dioxol-5-yl)-2-(piperidin-1-yl)hexa-3,5-dienenitrile

(3E,5E)-6-(benzo[d][1,3]dioxol-5-yl)-2-(piperidin-1-yl)hexa-3,5-dienenitrile

Conditions
ConditionsYield
Stage #1: Piperine With bis(triphenylphosphine)iridium(I) carbonyl chloride In toluene at 20℃; for 0.0833333h;
Stage #2: With 1,1,3,3-Tetramethyldisiloxane In toluene at 20℃; for 0.0833333h;
Stage #3: With trimethylsilyl cyanide In toluene at 20℃; for 0.5h;
81%
diethyl 2-chloromalonate
14064-10-9

diethyl 2-chloromalonate

Piperine
94-62-2

Piperine

(3R,6S)-3-Benzo[1,3]dioxol-5-yl-6-(piperidine-1-carbonyl)-3,6-dihydro-thiopyran-2,2-dicarboxylic acid diethyl ester
139059-84-0

(3R,6S)-3-Benzo[1,3]dioxol-5-yl-6-(piperidine-1-carbonyl)-3,6-dihydro-thiopyran-2,2-dicarboxylic acid diethyl ester

Conditions
ConditionsYield
With caesium carbonate; sulfur In acetonitrile Heating;80%
Piperine
94-62-2

Piperine

SCT-63

SCT-63

Conditions
ConditionsYield
With diisobutylaluminium hydride In toluene at -10℃; for 0.5h;80%
With lithium aluminium tetrahydride In tetrahydrofuran for 72h; Inert atmosphere;34%
With sodium tetrahydroborate; iodine In tetrahydrofuran at 0℃; for 48h;13%
With lithium aluminium tetrahydride In diethyl ether for 24h; Reduction; Heating;
With sodium tetrahydroborate; iodine In tetrahydrofuran at 0℃; for 48h; Inert atmosphere;
Piperine
94-62-2

Piperine

(2E,4E)-5-(3,4-dihydroxyphenyl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

(2E,4E)-5-(3,4-dihydroxyphenyl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

Conditions
ConditionsYield
With boron tribromide In dichloromethane at 20℃; for 48h;76.2%
With boron tribromide In dichloromethane at -15 - 20℃; for 24h;53%
With boron tribromide In dichloromethane at 0 - 20℃; for 16h;50%
Piperine
94-62-2

Piperine

4,5-(trans)-2,3-epoxy piperylpiperidine

4,5-(trans)-2,3-epoxy piperylpiperidine

Conditions
ConditionsYield
With dihydrogen peroxide at 37℃; for 18h; Horseradish peroxidase, 0,1M sodium phosphate buffer, pH 6,5;75%
Piperine
94-62-2

Piperine

(E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)pent-4-en-1-one

(E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)pent-4-en-1-one

Conditions
ConditionsYield
With sodium tetrahydroborate; iodine In tetrahydrofuran at 0℃; for 0.333333h;74%
Piperine
94-62-2

Piperine

nigramide B

nigramide B

chabamide

chabamide

(E)-3-(2,6-bis(benzo[d][1,3]dioxol-5-yl)-5-(piperidine-1-carbonyl)cyclohex-3-en-1-yl)-1-(piperidin-1-yl)prop-2-en-1-one

(E)-3-(2,6-bis(benzo[d][1,3]dioxol-5-yl)-5-(piperidine-1-carbonyl)cyclohex-3-en-1-yl)-1-(piperidin-1-yl)prop-2-en-1-one

[(1S,5R,6R)-5-Benzo[1,3]dioxol-5-yl-6-((E)-2-benzo[1,3]dioxol-5-yl-vinyl)-2-(piperidine-1-carbonyl)-cyclohex-2-enyl]-piperidin-1-yl-methanone

[(1S,5R,6R)-5-Benzo[1,3]dioxol-5-yl-6-((E)-2-benzo[1,3]dioxol-5-yl-vinyl)-2-(piperidine-1-carbonyl)-cyclohex-2-enyl]-piperidin-1-yl-methanone

Conditions
ConditionsYield
With rac-3-octanol; triphenylphosphine; cobalt(II) chloride at 170℃; for 72h; Diels-Alder reaction; Further byproducts given;A 11%
B 74%
C 9%
D 4%
With rac-3-octanol; cobalt(II) chloride at 170℃; for 72h; Diels-Alder reaction;A 15%
B 41%
C 3%
D 41%
With cobalt(II) chloride In various solvent(s) at 177℃; for 72h; Diels-Alder reaction;A 4.2%
B 11.5%
C 1%
D 11.5%
Piperine
94-62-2

Piperine

sodium piperonyl pentadienoate
161196-18-5

sodium piperonyl pentadienoate

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 86.5℃; for 24h; Concentration; Temperature; Time;70.03%
Multi-step reaction with 3 steps
1: potassium hydroxide / ethanol / Reflux
2: sulfuric acid / water
3: sodium hydroxide / ethanol / 1 h / 80.5 °C
View Scheme
diethyl 2-chloromalonate
14064-10-9

diethyl 2-chloromalonate

Piperine
94-62-2

Piperine

A

1,1,2,2-tetracarboethoxy-ethylene
6174-95-4

1,1,2,2-tetracarboethoxy-ethylene

(3R,6S)-3-Benzo[1,3]dioxol-5-yl-6-(piperidine-1-carbonyl)-3,6-dihydro-selenopyran-2,2-dicarboxylic acid diethyl ester
139059-85-1

(3R,6S)-3-Benzo[1,3]dioxol-5-yl-6-(piperidine-1-carbonyl)-3,6-dihydro-selenopyran-2,2-dicarboxylic acid diethyl ester

Conditions
ConditionsYield
With selenium; caesium carbonate In acetonitrile Heating;A 70%
B 24%
Piperine
94-62-2

Piperine

[(1S,2R,5S,6R)-2-Benzo[1,3]dioxol-5-yl-6-((E)-2-benzo[1,3]dioxol-5-yl-vinyl)-5-(piperidine-1-carbonyl)-cyclohex-3-enyl]-piperidin-1-yl-methanone

[(1S,2R,5S,6R)-2-Benzo[1,3]dioxol-5-yl-6-((E)-2-benzo[1,3]dioxol-5-yl-vinyl)-5-(piperidine-1-carbonyl)-cyclohex-3-enyl]-piperidin-1-yl-methanone

(E)-3-[(1S,2S,5R,6S)-5,6-Bis-benzo[1,3]dioxol-5-yl-2-(piperidine-1-carbonyl)-cyclohex-3-enyl]-1-piperidin-1-yl-propenone

(E)-3-[(1S,2S,5R,6S)-5,6-Bis-benzo[1,3]dioxol-5-yl-2-(piperidine-1-carbonyl)-cyclohex-3-enyl]-1-piperidin-1-yl-propenone

(E)-3-[(1R,2S,5R,6S)-2,6-Bis-benzo[1,3]dioxol-5-yl-5-(piperidine-1-carbonyl)-cyclohex-3-enyl]-1-piperidin-1-yl-propenone

(E)-3-[(1R,2S,5R,6S)-2,6-Bis-benzo[1,3]dioxol-5-yl-5-(piperidine-1-carbonyl)-cyclohex-3-enyl]-1-piperidin-1-yl-propenone

chabamide

chabamide

Conditions
ConditionsYield
With rac-3-octanol; triphenylphosphine; cobalt(II) chloride at 170℃; for 72h; Diels-Alder reaction; Further byproducts given;A 2%
B 3%
C 2%
D 62%
Piperine
94-62-2

Piperine

A

tetrahydropiperine
23434-88-0

tetrahydropiperine

B

(E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)pent-4-en-1-one

(E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)pent-4-en-1-one

Conditions
ConditionsYield
With sodium tetrahydroborate; iodine In tetrahydrofuran at 0℃; for 0.333333h;A 58%
B 14%
N-benzyl C-(trifluoromethyl)nitrone

N-benzyl C-(trifluoromethyl)nitrone

Piperine
94-62-2

Piperine

5-(((E)-2-(benzo[d][1,3]dioxol-5-yl)vinyl)-2-benzyl-3-(trifluoromethyl)isoxazolidin-4-yl)(piperidin-1-yl)methanone

5-(((E)-2-(benzo[d][1,3]dioxol-5-yl)vinyl)-2-benzyl-3-(trifluoromethyl)isoxazolidin-4-yl)(piperidin-1-yl)methanone

Conditions
ConditionsYield
In toluene at 70 - 80℃; chemoselective reaction;58%
N-t-butyltrifluoromethylnitrone
2344-50-5

N-t-butyltrifluoromethylnitrone

Piperine
94-62-2

Piperine

5-(((E)-2-(benzo[d][1,3]dioxol-5-yl)vinyl)-tert-butyl-3-(trifluoromethyl)isoxazolidin-4-yl)(piperidin-1-yl)methanone

5-(((E)-2-(benzo[d][1,3]dioxol-5-yl)vinyl)-tert-butyl-3-(trifluoromethyl)isoxazolidin-4-yl)(piperidin-1-yl)methanone

Conditions
ConditionsYield
In toluene at 70 - 80℃; chemoselective reaction;49%
Piperine
94-62-2

Piperine

(2Z,4Z)-3,5-diamino-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

(2Z,4Z)-3,5-diamino-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

Conditions
ConditionsYield
Stage #1: Piperine With sulfur In dimethyl sulfoxide at 20℃; Sealed tube;
Stage #2: With ammonium carbonate In dimethyl sulfoxide at 80℃; for 12h; Sealed tube;
48%
Piperine
94-62-2

Piperine

4R,5R-dihydroxypiperine

4R,5R-dihydroxypiperine

Conditions
ConditionsYield
Stage #1: Piperine With potassium osmate(VI) dihydrate; (DHQ)2PHAL; potassium carbonate; potassium hexacyanoferrate(III) In water; tert-butyl alcohol at 20℃; for 24h;
Stage #2: With sodium sulfite In water; tert-butyl alcohol at 20℃; for 12h;
44.5%
With potassium osmate(VI) dihydrate; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III) In water; tert-butyl alcohol at 20℃; for 24h;44.5%
Piperine
94-62-2

Piperine

4S,5S-dihydroxypiperine

4S,5S-dihydroxypiperine

Conditions
ConditionsYield
Stage #1: Piperine With potassium osmate(VI) dihydrate; (DHQD)2PHAL; potassium carbonate; potassium hexacyanoferrate(III) In water; tert-butyl alcohol at 20℃; for 24h;
Stage #2: With sodium sulfite In water; tert-butyl alcohol at 20℃; for 12h;
44.4%
With potassium osmate(VI) dihydrate; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III) In water; tert-butyl alcohol at 20℃; for 24h;44.4%
Piperine
94-62-2

Piperine

nigramide B

nigramide B

chabamide

chabamide

(E)-3-(2,6-bis(benzo[d][1,3]dioxol-5-yl)-5-(piperidine-1-carbonyl)cyclohex-3-en-1-yl)-1-(piperidin-1-yl)prop-2-en-1-one

(E)-3-(2,6-bis(benzo[d][1,3]dioxol-5-yl)-5-(piperidine-1-carbonyl)cyclohex-3-en-1-yl)-1-(piperidin-1-yl)prop-2-en-1-one

Conditions
ConditionsYield
at 130℃; for 72h; Diels-Alder reaction;A 9.7%
B 41%
C 6.3%
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