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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3,4-(Methylenedioxy)cinnamic acid Manufacturer/High quality/Best price/In stock

Cas:2373-80-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply trans-3,4-(methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 3,4-(Methylenedioxy)cinnamic acid 2373-80-0 Producer

Cas:2373-80-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,4-(Methylenedioxy)-cinnamic acid

Cas:2373-80-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 2373-80-0 with best quality

Cas:2373-80-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:

3,4-MethylenedioxycinnaMic Acid

Cas:2373-80-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

2-Propenoic acid,3-(1,3-benzodioxol-5-yl)-

Cas:2373-80-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

3,4-(Methylenedioxy)cinnamic acid CAS:2373-80-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

3,4-(Methylenedioxy)cinnamic acid CAS:2373-80-0

Cas:2373-80-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Propenoic acid,3-(1,3-benzodioxol-5-yl)-

Cas:2373-80-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:2373-80-0

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

NANJING SUNNY PHARMATECH CO., LTD

Our product has a very high quality and now we are exporting to customers overseas with very positive feedback. With best price, quality and service from Nanjing Sunny, we are confident to set up a very nice cooperation with customers all over the w

high purity 3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

2-Propenoic acid,3-(1,3-benzodioxol-5-yl)-

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3,4-(Methylenedioxy)Cinnamic Acid cas no. 2373-80-0 98%

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

3,4-(Methylenedioxy)cinnamic acidAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 3,4-Methylenedioxycinnamic acid 25g

Cas:2373-80-0

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Propenoic acid,3-(1,3-benzodioxol-5-yl)-

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

3,4-(Methylenedioxy)cinnamic acid CAS No.2373-80-0

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

3,4-(Methylenedioxy)cinnamic acid cas 2373-80-0Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3,4-(Methylenedioxy)cinnamic acid cas 2373-80-0

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5g Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

3,4-(Methylenedioxy)cinnamic acid

Cas:2373-80-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate
40918-96-5

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Stage #1: methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate With water; sodium hydroxide In tetrahydrofuran
Stage #2: With hydrogenchloride In water pH=< 3;
99%
With sodium hydroxide In tetrahydrofuran; methanol at 40℃; Inert atmosphere;81%
With potassium hydroxide In ethanol; water Heating;15 mg
piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With aluminum oxide; lithium chloride for 0.1h; Doebner condensation; microwave irradiation;98%
With piperidine; pyridine for 1h; Knoevenagel-Doebner-Stobbe Reaction; Reflux;98%
With ammonium acetate for 0.0666667h; Irradiation;97%
piperonal
120-57-0

piperonal

acetic acid
64-19-7

acetic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Stage #1: piperonal; acetic acid With titanium tetrachloride In dichloromethane at 25℃; for 0.333333h; Inert atmosphere;
Stage #2: With triethylamine In dichloromethane at 25℃; Inert atmosphere; stereoselective reaction;
98%
(2RS,3SR)-2,3-dibromo-3-(3,4-methylenedioxyphenyl)propanoic acid

(2RS,3SR)-2,3-dibromo-3-(3,4-methylenedioxyphenyl)propanoic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With zinc In acetic acid at 20℃; for 0.0166667h; microwave irradiation;96%
3,4-methylenedioxycinnamic acid benzhydryl ester
85580-21-8

3,4-methylenedioxycinnamic acid benzhydryl ester

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With formic acid at 40 - 45℃; for 0.5h; Product distribution;89%
(E)-2'-hydroxy-3,4-methylenedioxychalcone
16669-99-1

(E)-2'-hydroxy-3,4-methylenedioxychalcone

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With dihydrogen peroxide; potassium carbonate In acetonitrile at 20℃; for 5h;89%
piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

A

5-vinyl-1,3-benzodioxole
7315-32-4

5-vinyl-1,3-benzodioxole

B

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With pyridine; acetic acid at 130℃; for 0.133333h; Knoevenagel-Doebner reaction; microwave irradiation;A 4 % Spectr.
B 85%
piperonal
120-57-0

piperonal

acetic anhydride
108-24-7

acetic anhydride

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With potassium acetate for 6h; Heating;50%
With sodium acetate
wikstromol
117824-56-3

wikstromol

Sodium; 3-benzo[1,3]dioxol-5-yl-2-iodo-propionate

Sodium; 3-benzo[1,3]dioxol-5-yl-2-iodo-propionate

A

4-Benzenesulfonylamino-2-benzo[1,3]dioxol-5-ylmethyl-4-oxo-3-(3,4,5-trimethoxy-benzyl)-butyric acid
118975-42-1

4-Benzenesulfonylamino-2-benzo[1,3]dioxol-5-ylmethyl-4-oxo-3-(3,4,5-trimethoxy-benzyl)-butyric acid

B

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With n-butyllithium 1) -78 --> 0 deg C, several hours; 2) -78 --> RT; Yield given. Multistep reaction;A n/a
B 30%
piperonal
120-57-0

piperonal

sodium acetate
127-09-3

sodium acetate

acetic anhydride
108-24-7

acetic anhydride

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

acetic acid
64-19-7

acetic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

piperonal
120-57-0

piperonal

ethyl acetate
141-78-6

ethyl acetate

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With sodium Behandeln mit methylalkoholischer Kalilauge;
piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

dimethyl amine
124-40-3

dimethyl amine

A

3-benzo[1,3]dioxol-5-yl-3-methylamino-propionic acid

3-benzo[1,3]dioxol-5-yl-3-methylamino-propionic acid

B

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

ethyl (E)-3-(benzo[d][1,3]dioxol-5-yl)acrylate
24393-66-6

ethyl (E)-3-(benzo[d][1,3]dioxol-5-yl)acrylate

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With potassium hydroxide
With water; potassium hydroxide In tetrahydrofuran
3-(3,4,5-trimethoxyphenyl)propanoic acid
25173-72-2

3-(3,4,5-trimethoxyphenyl)propanoic acid

Sodium; 3-benzo[1,3]dioxol-5-yl-2-iodo-propionate

Sodium; 3-benzo[1,3]dioxol-5-yl-2-iodo-propionate

A

2-piperonyl-3-(3,4,5-trimethoxy-benzyl)-succinic acid
139747-16-3

2-piperonyl-3-(3,4,5-trimethoxy-benzyl)-succinic acid

B

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With lithium diisopropyl amide Yield given;
piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

ammonia
7664-41-7

ammonia

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

3-benzo<1,3>dioxol-5-acrylic acid isobutylamide

3-benzo<1,3>dioxol-5-acrylic acid isobutylamide

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With potassium hydroxide
ethanol
64-17-5

ethanol

dihydrogen peroxide
7722-84-1

dihydrogen peroxide

4-benzo[1,3]dioxol-5-yl-2-oxo-but-3-enoic acid
69662-23-3

4-benzo[1,3]dioxol-5-yl-2-oxo-but-3-enoic acid

KOH-solution

KOH-solution

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

potassium salt of/the/ piperonylidenepyruvic acid

potassium salt of/the/ piperonylidenepyruvic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With ethanol; dihydrogen peroxide
piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

ammonia
7664-41-7

ammonia

A

piperonylidene-malonic acid
4436-15-1

piperonylidene-malonic acid

B

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

C

β-amino-β-<3.4-methylenedioxy-phenyl>-propionic acid

β-amino-β-<3.4-methylenedioxy-phenyl>-propionic acid

caffeic acid
331-39-5

caffeic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 304 mg / conc. H2SO4 / 1 h / Heating
2: K2CO3, Cu0 / dimethylformamide / 1 h / Heating
3: 15 mg / KOH / ethanol; H2O / Heating
View Scheme
Methyl caffeate
3843-74-1, 67667-67-8

Methyl caffeate

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3, Cu0 / dimethylformamide / 1 h / Heating
2: 15 mg / KOH / ethanol; H2O / Heating
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 110 °C / Inert atmosphere
2: sodium hydroxide / methanol; tetrahydrofuran / 40 °C / Inert atmosphere
View Scheme
3-(1,3 benzodioxol-5-yl)propionic acid
2815-95-4

3-(1,3 benzodioxol-5-yl)propionic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) LDA, 2.) CBr4 / 1) THF, -78 deg C (45 min), 0 deg C (3 1/4 h), RT (1 h); 2) THF, -78 deg C, 2 h
2: 92 percent / KI / acetone / 24 h / Heating
3: NaH / 0 °C
4: 1.) LDA
View Scheme
Multi-step reaction with 4 steps
1: 1.) LDA, 2.) CBr4 / 1) THF, -78 deg C (45 min), 0 deg C (3 1/4 h), RT (1 h); 2) THF, -78 deg C, 2 h
2: 92 percent / KI / acetone / 24 h / Heating
3: NaH / 0 °C
4: 30 percent / 1.) n-BuLi / 1) -78 --> 0 deg C, several hours; 2) -78 --> RT
View Scheme
Multi-step reaction with 3 steps
1: 1.) LDA, 2.) iodine / 1) THF, -78 deg C (45 min), 0 deg C (3 1/4 h), RT (1 h); 2) THF, -78 deg C, 10 min
2: NaH / 0 °C
3: 1.) LDA
View Scheme
Multi-step reaction with 3 steps
1: 1.) LDA, 2.) iodine / 1) THF, -78 deg C (45 min), 0 deg C (3 1/4 h), RT (1 h); 2) THF, -78 deg C, 10 min
2: NaH / 0 °C
3: 30 percent / 1.) n-BuLi / 1) -78 --> 0 deg C, several hours; 2) -78 --> RT
View Scheme
3-(3,4-methylenedioxyphenyl)-2-bromopropionic acid
56183-75-6

3-(3,4-methylenedioxyphenyl)-2-bromopropionic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / KI / acetone / 24 h / Heating
2: NaH / 0 °C
3: 1.) LDA
View Scheme
Multi-step reaction with 3 steps
1: 92 percent / KI / acetone / 24 h / Heating
2: NaH / 0 °C
3: 30 percent / 1.) n-BuLi / 1) -78 --> 0 deg C, several hours; 2) -78 --> RT
View Scheme
3-Benzo[1,3]dioxol-5-yl-2-iodo-propionic acid
118975-38-5

3-Benzo[1,3]dioxol-5-yl-2-iodo-propionic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH / 0 °C
2: 1.) LDA
View Scheme
Multi-step reaction with 2 steps
1: NaH / 0 °C
2: 30 percent / 1.) n-BuLi / 1) -78 --> 0 deg C, several hours; 2) -78 --> RT
View Scheme
piperonal
120-57-0

piperonal

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; piperidine
2: ethanolic KOH-solution
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / 0 °C
2: potassium hydroxide; water / tetrahydrofuran
View Scheme
3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / 60 °C
2: pyridine; piperidine / 24 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetone / 29 h / 50 - 60 °C
2: pyridine; piperidine / 24 h / 80 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C
2.1: pyridine / 0.17 h / 20 °C
2.2: 4 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / Reflux
2: pyridine; piperidine / 24 h / 80 °C
View Scheme
benzene-1,2-diol
120-80-9

benzene-1,2-diol

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 80 °C
2: acetic anhydride / isopropyl alcohol / 1 h / 55 - 110 °C
3: piperidine; pyridine / 2 h / 115 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 80 °C
2.1: acetic anhydride / isopropyl alcohol / 0.5 h / 55 °C
2.2: 1 h / 110 °C
2.3: 3 h
3.1: pyridine; piperidine / 2 h / 115 °C
View Scheme
Methylenedioxybenzene
274-09-9

Methylenedioxybenzene

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic anhydride / isopropyl alcohol / 1 h / 55 - 110 °C
2: piperidine; pyridine / 2 h / 115 °C
View Scheme
Multi-step reaction with 2 steps
1.1: acetic anhydride / isopropyl alcohol / 0.5 h / 55 °C
1.2: 1 h / 110 °C
1.3: 3 h
2.1: pyridine; piperidine / 2 h / 115 °C
View Scheme
3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

3-(1,3 benzodioxol-5-yl)propionic acid
2815-95-4

3-(1,3 benzodioxol-5-yl)propionic acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In N,N-dimethyl-formamide under 760 Torr; for 24h;100%
With palladium 10% on activated carbon; hydrogen; acetic acid In methanol at 20℃; for 22h;99%
With 10% Pd/C; cyclohexa-1,4-diene In methanol at 100℃; for 0.0833333h; Microwave irradiation;95%
3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

(E)-3-(1,3-benzodioxol-5-yl)acryloyl chloride
96249-87-5

(E)-3-(1,3-benzodioxol-5-yl)acryloyl chloride

Conditions
ConditionsYield
With oxalyl dichloride at 25℃; for 0.5h;100%
With oxalyl dichloride at 25℃; for 2h;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃;100%
methanol
67-56-1

methanol

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate
40918-96-5

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate

Conditions
ConditionsYield
With sulfuric acid Heating;99%
With sulfuric acid for 24h; Reflux;98%
With sulfuric acid for 0.166667h; Esterification; Irradiation;96%
3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate
40918-96-5

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate

Conditions
ConditionsYield
In methanol; diethyl ether at 20℃; for 0.25h; Inert atmosphere;99%
2 g
In methanol; diethyl ether at 0℃; for 0.666667h; Esterification;
4-Chloro-3,5-dimethylphenol
88-04-0

4-Chloro-3,5-dimethylphenol

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

4-(benzo[d][1,3]dioxol-5-yl)-6-chloro-5,7-dimethyl-3,4-dihydrochromen-2-one
850496-03-6

4-(benzo[d][1,3]dioxol-5-yl)-6-chloro-5,7-dimethyl-3,4-dihydrochromen-2-one

Conditions
ConditionsYield
With trifluoroacetic acid for 23h;99%
With trifluoroacetic acid
methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate
40918-96-5

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Stage #1: methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate With water; sodium hydroxide In tetrahydrofuran
Stage #2: With hydrogenchloride In water pH=< 3;
99%
With sodium hydroxide In tetrahydrofuran; methanol at 40℃; Inert atmosphere;81%
With potassium hydroxide In ethanol; water Heating;15 mg
piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With aluminum oxide; lithium chloride for 0.1h; Doebner condensation; microwave irradiation;98%
With piperidine; pyridine for 1h; Knoevenagel-Doebner-Stobbe Reaction; Reflux;98%
With ammonium acetate for 0.0666667h; Irradiation;97%
piperonal
120-57-0

piperonal

acetic acid
64-19-7

acetic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Stage #1: piperonal; acetic acid With titanium tetrachloride In dichloromethane at 25℃; for 0.333333h; Inert atmosphere;
Stage #2: With triethylamine In dichloromethane at 25℃; Inert atmosphere; stereoselective reaction;
98%
(2RS,3SR)-2,3-dibromo-3-(3,4-methylenedioxyphenyl)propanoic acid

(2RS,3SR)-2,3-dibromo-3-(3,4-methylenedioxyphenyl)propanoic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With zinc In acetic acid at 20℃; for 0.0166667h; microwave irradiation;96%
3,4-methylenedioxycinnamic acid benzhydryl ester
85580-21-8

3,4-methylenedioxycinnamic acid benzhydryl ester

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With formic acid at 40 - 45℃; for 0.5h; Product distribution;89%
(E)-2'-hydroxy-3,4-methylenedioxychalcone
16669-99-1

(E)-2'-hydroxy-3,4-methylenedioxychalcone

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With dihydrogen peroxide; potassium carbonate In acetonitrile at 20℃; for 5h;89%
piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

A

5-vinyl-1,3-benzodioxole
7315-32-4

5-vinyl-1,3-benzodioxole

B

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With pyridine; acetic acid at 130℃; for 0.133333h; Knoevenagel-Doebner reaction; microwave irradiation;A 4 % Spectr.
B 85%
piperonal
120-57-0

piperonal

acetic anhydride
108-24-7

acetic anhydride

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With potassium acetate for 6h; Heating;50%
With sodium acetate
wikstromol
117824-56-3

wikstromol

Sodium; 3-benzo[1,3]dioxol-5-yl-2-iodo-propionate

Sodium; 3-benzo[1,3]dioxol-5-yl-2-iodo-propionate

A

4-Benzenesulfonylamino-2-benzo[1,3]dioxol-5-ylmethyl-4-oxo-3-(3,4,5-trimethoxy-benzyl)-butyric acid
118975-42-1

4-Benzenesulfonylamino-2-benzo[1,3]dioxol-5-ylmethyl-4-oxo-3-(3,4,5-trimethoxy-benzyl)-butyric acid

B

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With n-butyllithium 1) -78 --> 0 deg C, several hours; 2) -78 --> RT; Yield given. Multistep reaction;A n/a
B 30%
piperonal
120-57-0

piperonal

sodium acetate
127-09-3

sodium acetate

acetic anhydride
108-24-7

acetic anhydride

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

acetic acid
64-19-7

acetic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

piperonal
120-57-0

piperonal

ethyl acetate
141-78-6

ethyl acetate

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With sodium Behandeln mit methylalkoholischer Kalilauge;
piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

dimethyl amine
124-40-3

dimethyl amine

A

3-benzo[1,3]dioxol-5-yl-3-methylamino-propionic acid

3-benzo[1,3]dioxol-5-yl-3-methylamino-propionic acid

B

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

ethyl (E)-3-(benzo[d][1,3]dioxol-5-yl)acrylate
24393-66-6

ethyl (E)-3-(benzo[d][1,3]dioxol-5-yl)acrylate

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With potassium hydroxide
With water; potassium hydroxide In tetrahydrofuran
3-(3,4,5-trimethoxyphenyl)propanoic acid
25173-72-2

3-(3,4,5-trimethoxyphenyl)propanoic acid

Sodium; 3-benzo[1,3]dioxol-5-yl-2-iodo-propionate

Sodium; 3-benzo[1,3]dioxol-5-yl-2-iodo-propionate

A

2-piperonyl-3-(3,4,5-trimethoxy-benzyl)-succinic acid
139747-16-3

2-piperonyl-3-(3,4,5-trimethoxy-benzyl)-succinic acid

B

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With lithium diisopropyl amide Yield given;
piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

ammonia
7664-41-7

ammonia

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

3-benzo<1,3>dioxol-5-acrylic acid isobutylamide

3-benzo<1,3>dioxol-5-acrylic acid isobutylamide

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With potassium hydroxide
ethanol
64-17-5

ethanol

dihydrogen peroxide
7722-84-1

dihydrogen peroxide

4-benzo[1,3]dioxol-5-yl-2-oxo-but-3-enoic acid
69662-23-3

4-benzo[1,3]dioxol-5-yl-2-oxo-but-3-enoic acid

KOH-solution

KOH-solution

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

potassium salt of/the/ piperonylidenepyruvic acid

potassium salt of/the/ piperonylidenepyruvic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
With ethanol; dihydrogen peroxide
piperonal
120-57-0

piperonal

malonic acid
141-82-2

malonic acid

ammonia
7664-41-7

ammonia

A

piperonylidene-malonic acid
4436-15-1

piperonylidene-malonic acid

B

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

C

β-amino-β-<3.4-methylenedioxy-phenyl>-propionic acid

β-amino-β-<3.4-methylenedioxy-phenyl>-propionic acid

caffeic acid
331-39-5

caffeic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 304 mg / conc. H2SO4 / 1 h / Heating
2: K2CO3, Cu0 / dimethylformamide / 1 h / Heating
3: 15 mg / KOH / ethanol; H2O / Heating
View Scheme
Methyl caffeate
3843-74-1, 67667-67-8

Methyl caffeate

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3, Cu0 / dimethylformamide / 1 h / Heating
2: 15 mg / KOH / ethanol; H2O / Heating
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 110 °C / Inert atmosphere
2: sodium hydroxide / methanol; tetrahydrofuran / 40 °C / Inert atmosphere
View Scheme
3-(1,3 benzodioxol-5-yl)propionic acid
2815-95-4

3-(1,3 benzodioxol-5-yl)propionic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) LDA, 2.) CBr4 / 1) THF, -78 deg C (45 min), 0 deg C (3 1/4 h), RT (1 h); 2) THF, -78 deg C, 2 h
2: 92 percent / KI / acetone / 24 h / Heating
3: NaH / 0 °C
4: 1.) LDA
View Scheme
Multi-step reaction with 4 steps
1: 1.) LDA, 2.) CBr4 / 1) THF, -78 deg C (45 min), 0 deg C (3 1/4 h), RT (1 h); 2) THF, -78 deg C, 2 h
2: 92 percent / KI / acetone / 24 h / Heating
3: NaH / 0 °C
4: 30 percent / 1.) n-BuLi / 1) -78 --> 0 deg C, several hours; 2) -78 --> RT
View Scheme
Multi-step reaction with 3 steps
1: 1.) LDA, 2.) iodine / 1) THF, -78 deg C (45 min), 0 deg C (3 1/4 h), RT (1 h); 2) THF, -78 deg C, 10 min
2: NaH / 0 °C
3: 1.) LDA
View Scheme
Multi-step reaction with 3 steps
1: 1.) LDA, 2.) iodine / 1) THF, -78 deg C (45 min), 0 deg C (3 1/4 h), RT (1 h); 2) THF, -78 deg C, 10 min
2: NaH / 0 °C
3: 30 percent / 1.) n-BuLi / 1) -78 --> 0 deg C, several hours; 2) -78 --> RT
View Scheme
3-(3,4-methylenedioxyphenyl)-2-bromopropionic acid
56183-75-6

3-(3,4-methylenedioxyphenyl)-2-bromopropionic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / KI / acetone / 24 h / Heating
2: NaH / 0 °C
3: 1.) LDA
View Scheme
Multi-step reaction with 3 steps
1: 92 percent / KI / acetone / 24 h / Heating
2: NaH / 0 °C
3: 30 percent / 1.) n-BuLi / 1) -78 --> 0 deg C, several hours; 2) -78 --> RT
View Scheme
3-Benzo[1,3]dioxol-5-yl-2-iodo-propionic acid
118975-38-5

3-Benzo[1,3]dioxol-5-yl-2-iodo-propionic acid

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH / 0 °C
2: 1.) LDA
View Scheme
Multi-step reaction with 2 steps
1: NaH / 0 °C
2: 30 percent / 1.) n-BuLi / 1) -78 --> 0 deg C, several hours; 2) -78 --> RT
View Scheme
piperonal
120-57-0

piperonal

3,4-methylenedioxy-trans-cinnamic acid
2373-80-0

3,4-methylenedioxy-trans-cinnamic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; piperidine
2: ethanolic KOH-solution
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / 0 °C
2: potassium hydroxide; water / tetrahydrofuran
View Scheme

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