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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 5,6-dihydroxyindole

Cas:3131-52-0

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 3131-52-0 5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Leader Biochemical Group

About Product Details

China Biggest factory Manufacturer Supply High Quality 5,6-DIHYDROXYINDOLE CAS 3131-52-0

Cas:3131-52-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

5, 6-Dihydroxyindole Dhi CAS 3131-52-0

Cas:3131-52-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 3131-52-0 with competitive price

Cas:3131-52-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5,6-Dihydroxyindole 3131-52-0

Cas:3131-52-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

5,6-DIHYDROXYINDOLE

Cas:3131-52-0

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 5,6-DIHYDROXYINDOLE Synonyms: INDOLE-5,6-DIOL;DOPAMINE LUTINE;5,6-DIHYDROXYINDOLE;DIHYDROXYINDOLE;5,6-Dihydroxy-1H-indole;1H-indole-5,6-diol;5,6-DIYDROXYINDOLE;5.6-Dihydroxy Indol CAS: 3131-52-0 MF: C8H7NO2 MW: 149.15 EIN

5,6-DIHYDROXYINDOLE

Cas:3131-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

5,6-dihydroxyindole 99%

Cas:3131-52-0

Min.Order:1 Kilogram

FOB Price: $35.0 / 42.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

5,6-DIHYDROXYINDOLE CAS:3131-52-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm

5,6-DIHYDROXYINDOLE CAS:3131-52-0

Cas:3131-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 3131-52-0 5,6-DIHYDROXYINDOLE

Cas:3131-52-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory 5,6-dihydroxyindole in stock

Cas:3131-52-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. 5,6-Dihydroxyindole is an intermediate in melanogenesis, the production of melanin which is found in our skin, eyes, hair, and inner ear. Kind Pharma has its own laboratory, we can do analytical testing f

5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Manufacturer Supply High Quality 5,6-DIHYDROXYINDOLE CAS 3131-52-0 Item Standard Identification A.H-NMR:Comply with the structure B.LC-MS:Comply with the structure

High Quality 5,6-DIHYDROXYINDOLE CAS 3131-52-0 purity 99%

Cas:3131-52-0

Min.Order:1 Kilogram

FOB Price: $8.0 / 11.0

Type:Trading Company

inquiry

Zhejiang Huili Pharmaceutical Co., Ltd

ProName: 5,6-Dihydroxyindole CasNo: 3131-52-0 Molecular Formula: C8H7NO2 Appearance: detailed see specifications Application: It is an important raw material and in... DeliveryTime: prompt PackAge: according to the clients requirement Port:

5,6-dihydroxyindole

Cas:3131-52-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Specif

5,6-Dihydroxyindole CAS 3131-52-0

Cas:3131-52-0

Min.Order:1 Kilogram

FOB Price: $75.0 / 150.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi New nine Material Technology Co., Ltd.

Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Professional R&D

5,6-Dihydroxyindole CAS NO.3131-52-0

Cas:3131-52-0

Min.Order:10 Gram

FOB Price: $5.0 / 10.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Factory customize 5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationship

3131-52-0 5,6-DIHYDROXYINDOLE

Cas:3131-52-0

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

5,6-Dihydroxy-1H-indole

Cas:3131-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 5,6-dihydroxyindole CAS No.:3131-52-0 Molecule Formula: C8H7NO2 Molecule Weight:149.14 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Lower Price 5,6-dihydroxyindole

Cas:3131-52-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best Price5,6-Dihydroxyindole

Cas:3131-52-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

5,6-dihydroxy-2-carboxyindole
4790-08-3

5,6-dihydroxy-2-carboxyindole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With hydrogenchloride for 18h; Heating;100%
C8H7NO2

C8H7NO2

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With sodium dithionite-hydrate; sodium hydrogencarbonate In water at 20 - 58℃; for 1h; Inert atmosphere;98.1%
5,6-dibenzyloxyindole
4790-19-6

5,6-dibenzyloxyindole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With Pd(0)EnCat; ammonium formate In N,N-dimethyl-formamide at 80℃; for 0.166667h; Irradiation; microwave;95%
5,6-diacetoxyindole
15069-79-1

5,6-diacetoxyindole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With potassium carbonate In methanol for 0.583333h;90%
With methanol; sodium hydroxide; water at 0℃; Reagens 4: Natriumdithionit;
With sodium hydroxide In ethanol
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With sodium L-ascorbate In water at 20℃; for 0.75h; Product distribution / selectivity;90%
With sodium chloride In water at 20℃; for 0.75h; Product distribution / selectivity;
5,6-dimethoxyindole
14430-23-0

5,6-dimethoxyindole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With hydrogenchloride; acetic acid In water Reagent/catalyst; Solvent; Reflux;85.7%
fumaric acid disodium salt
17013-01-3

fumaric acid disodium salt

5,6-dihydroxyindoline hydrobromide

5,6-dihydroxyindoline hydrobromide

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With sodium hydroxide; palladium-carbon In water76.5%
(E)-4,5-dihydroxy-2,β-dinitrostyrene
96806-57-4

(E)-4,5-dihydroxy-2,β-dinitrostyrene

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol under 2585.7 Torr; for 1h;76%
With sodium dithionite; phosphate buffer; zinc(II) sulfate In various solvent(s) at 40℃; for 0.333333h;52%
With hydrogen; palladium on activated charcoal In water under 2585.7 Torr; for 0.75h;50%
ammonium persulfate

ammonium persulfate

5,6-dihydroxyindoline hydrobromide

5,6-dihydroxyindoline hydrobromide

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With sodium hydroxide In water56%
5,6-diacetoxy-2,3-dihydro-indole
15937-11-8

5,6-diacetoxy-2,3-dihydro-indole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With potassium carbonate In methanol at 0℃; for 0.833333h; Inert atmosphere;54%
CH3 CO2 H

CH3 CO2 H

(E)-4,5-dihydroxy-2,β-dinitrostyrene
96806-57-4

(E)-4,5-dihydroxy-2,β-dinitrostyrene

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With H2; palladium-carbon In water50%
levodopa
59-92-7

levodopa

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With sodium hydrogencarbonate; potassium hexacyanoferrate(III) In water for 2.5h;45%
With sodium hydrogencarbonate; potassium hexacyanoferrate(III) In water at 20℃; for 3h; Inert atmosphere;27%
Multi-step reaction with 2 steps
1: 59 percent / air, phosphate buffer pH 7.0 / 2.5 h / 25 °C / mushroom tyrosinase
2: 100 percent / 6 M HCl / 18 h / Heating
View Scheme
Na2 S2 O4

Na2 S2 O4

(E)-4,5-dihydroxy-2,β-dinitrostyrene
96806-57-4

(E)-4,5-dihydroxy-2,β-dinitrostyrene

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With hydrogenchloride In benzene40%
6-aminodopamine dihydrochloride
42241-07-6, 54749-74-5

6-aminodopamine dihydrochloride

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

7-amino-8-(2-aminoethyl)-3-hydroxy-2-oxo-2,3,4,10-tetrahydro<3,4-a>iminoethanophenoxazine
145069-19-8

7-amino-8-(2-aminoethyl)-3-hydroxy-2-oxo-2,3,4,10-tetrahydro<3,4-a>iminoethanophenoxazine

Conditions
ConditionsYield
With air; sodium hydrogencarbonateA 20%
B n/a
With air; sodium hydrogencarbonate Product distribution; Mechanism; other reagents;A 20%
B n/a
5,6-(carbonyldioxy)indole
93578-30-4

5,6-(carbonyldioxy)indole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With water at 100℃; for 1h;15%
α-methyldopamine
555-64-6

α-methyldopamine

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

1-(2,4,5-trihydroxyphenyl)-2-aminopropane
41241-36-5

1-(2,4,5-trihydroxyphenyl)-2-aminopropane

C

6-nitrodopamine

6-nitrodopamine

Conditions
ConditionsYield
With dihydrogen peroxide; horseradish peroxidase; sodium nitrite In phosphate buffer at 37℃; pH=7.4; Product distribution; Kinetics; Further Variations:; pH-values; Reagents;A n/a
B 7.2%
C 1.7%
1-(2-amino-4,5-dihydroxyphenyl)-2-ethylamine
38411-80-2

1-(2-amino-4,5-dihydroxyphenyl)-2-ethylamine

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With water; sodium hydrogencarbonate mit Luft;
6-hydroxydopamine hydrobromide
636-00-0

6-hydroxydopamine hydrobromide

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With water; sodium hydrogencarbonate; potassium hexacyanoferrate(III)
dopamine
51-61-6

dopamine

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

2,3-dihydro-indolo-5,6-quinone
67992-45-4

2,3-dihydro-indolo-5,6-quinone

Conditions
ConditionsYield
In water-d2 at 24.9℃; for 0.583333h; Rate constant; Mechanism; Irradiation; other sensitizers: methylene blue, rose bengal, fluoresceine; other solvent: H2O.;
With Aβ40 In aq. acetate buffer at 37℃; for 1h; pH=7.4; Reagent/catalyst; pH-value;
glutathion
70-18-8

glutathion

dopachrome

dopachrome

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

4-S-glutathionyl-5,6-dihydroxyindole
103153-88-4

4-S-glutathionyl-5,6-dihydroxyindole

Conditions
ConditionsYield
0.025 M sodium phosphate buffer, pH=6.8;A 75 % Chromat.
B 10 % Chromat.
A 75 % Chromat.
B 10 % Chromat.
5,6-dihydroxy-2-carboxyindole
4790-08-3

5,6-dihydroxy-2-carboxyindole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With hydrogenchloride for 18h; Heating;100%
C8H7NO2

C8H7NO2

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With sodium dithionite-hydrate; sodium hydrogencarbonate In water at 20 - 58℃; for 1h; Inert atmosphere;98.1%
5,6-dibenzyloxyindole
4790-19-6

5,6-dibenzyloxyindole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With Pd(0)EnCat; ammonium formate In N,N-dimethyl-formamide at 80℃; for 0.166667h; Irradiation; microwave;95%
5,6-diacetoxyindole
15069-79-1

5,6-diacetoxyindole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With potassium carbonate In methanol for 0.583333h;90%
With methanol; sodium hydroxide; water at 0℃; Reagens 4: Natriumdithionit;
With sodium hydroxide In ethanol
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With sodium L-ascorbate In water at 20℃; for 0.75h; Product distribution / selectivity;90%
With sodium chloride In water at 20℃; for 0.75h; Product distribution / selectivity;
5,6-dimethoxyindole
14430-23-0

5,6-dimethoxyindole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With hydrogenchloride; acetic acid In water Reagent/catalyst; Solvent; Reflux;85.7%
fumaric acid disodium salt
17013-01-3

fumaric acid disodium salt

5,6-dihydroxyindoline hydrobromide

5,6-dihydroxyindoline hydrobromide

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With sodium hydroxide; palladium-carbon In water76.5%
(E)-4,5-dihydroxy-2,β-dinitrostyrene
96806-57-4

(E)-4,5-dihydroxy-2,β-dinitrostyrene

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol under 2585.7 Torr; for 1h;76%
With sodium dithionite; phosphate buffer; zinc(II) sulfate In various solvent(s) at 40℃; for 0.333333h;52%
With hydrogen; palladium on activated charcoal In water under 2585.7 Torr; for 0.75h;50%
ammonium persulfate

ammonium persulfate

5,6-dihydroxyindoline hydrobromide

5,6-dihydroxyindoline hydrobromide

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With sodium hydroxide In water56%
5,6-diacetoxy-2,3-dihydro-indole
15937-11-8

5,6-diacetoxy-2,3-dihydro-indole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With potassium carbonate In methanol at 0℃; for 0.833333h; Inert atmosphere;54%
CH3 CO2 H

CH3 CO2 H

(E)-4,5-dihydroxy-2,β-dinitrostyrene
96806-57-4

(E)-4,5-dihydroxy-2,β-dinitrostyrene

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With H2; palladium-carbon In water50%
levodopa
59-92-7

levodopa

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With sodium hydrogencarbonate; potassium hexacyanoferrate(III) In water for 2.5h;45%
With sodium hydrogencarbonate; potassium hexacyanoferrate(III) In water at 20℃; for 3h; Inert atmosphere;27%
Multi-step reaction with 2 steps
1: 59 percent / air, phosphate buffer pH 7.0 / 2.5 h / 25 °C / mushroom tyrosinase
2: 100 percent / 6 M HCl / 18 h / Heating
View Scheme
Na2 S2 O4

Na2 S2 O4

(E)-4,5-dihydroxy-2,β-dinitrostyrene
96806-57-4

(E)-4,5-dihydroxy-2,β-dinitrostyrene

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With hydrogenchloride In benzene40%
6-aminodopamine dihydrochloride
42241-07-6, 54749-74-5

6-aminodopamine dihydrochloride

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

7-amino-8-(2-aminoethyl)-3-hydroxy-2-oxo-2,3,4,10-tetrahydro<3,4-a>iminoethanophenoxazine
145069-19-8

7-amino-8-(2-aminoethyl)-3-hydroxy-2-oxo-2,3,4,10-tetrahydro<3,4-a>iminoethanophenoxazine

Conditions
ConditionsYield
With air; sodium hydrogencarbonateA 20%
B n/a
With air; sodium hydrogencarbonate Product distribution; Mechanism; other reagents;A 20%
B n/a
5,6-(carbonyldioxy)indole
93578-30-4

5,6-(carbonyldioxy)indole

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With water at 100℃; for 1h;15%
α-methyldopamine
555-64-6

α-methyldopamine

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

1-(2,4,5-trihydroxyphenyl)-2-aminopropane
41241-36-5

1-(2,4,5-trihydroxyphenyl)-2-aminopropane

C

6-nitrodopamine

6-nitrodopamine

Conditions
ConditionsYield
With dihydrogen peroxide; horseradish peroxidase; sodium nitrite In phosphate buffer at 37℃; pH=7.4; Product distribution; Kinetics; Further Variations:; pH-values; Reagents;A n/a
B 7.2%
C 1.7%
1-(2-amino-4,5-dihydroxyphenyl)-2-ethylamine
38411-80-2

1-(2-amino-4,5-dihydroxyphenyl)-2-ethylamine

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With water; sodium hydrogencarbonate mit Luft;
6-hydroxydopamine hydrobromide
636-00-0

6-hydroxydopamine hydrobromide

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With water; sodium hydrogencarbonate; potassium hexacyanoferrate(III)
dopamine
51-61-6

dopamine

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

2,3-dihydro-indolo-5,6-quinone
67992-45-4

2,3-dihydro-indolo-5,6-quinone

Conditions
ConditionsYield
In water-d2 at 24.9℃; for 0.583333h; Rate constant; Mechanism; Irradiation; other sensitizers: methylene blue, rose bengal, fluoresceine; other solvent: H2O.;
With Aβ40 In aq. acetate buffer at 37℃; for 1h; pH=7.4; Reagent/catalyst; pH-value;
glutathion
70-18-8

glutathion

dopachrome

dopachrome

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

4-S-glutathionyl-5,6-dihydroxyindole
103153-88-4

4-S-glutathionyl-5,6-dihydroxyindole

Conditions
ConditionsYield
0.025 M sodium phosphate buffer, pH=6.8;A 75 % Chromat.
B 10 % Chromat.
A 75 % Chromat.
B 10 % Chromat.
L-tyrosine
60-18-4

L-tyrosine

A

indole
120-72-9

indole

B

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

C

4,4'-Dihydroxybiphenyl
92-88-6

4,4'-Dihydroxybiphenyl

D

4-Hydroxyphenylpyruvic acid
156-39-8

4-Hydroxyphenylpyruvic acid

E

5,6,3-trihydroxyindole
3569-19-5

5,6,3-trihydroxyindole

F

anthranilic acid
118-92-3

anthranilic acid

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; oxygen; iron(II) sulfate; ascorbic acid In water at 30 - 32℃; for 2h; Product distribution; biomimetic hydroxylation, pH 6.7;
L-tyrosine
60-18-4

L-tyrosine

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

levodopa
59-92-7

levodopa

C

leucodopachromene
18766-67-1

leucodopachromene

D

(2S)-dopachrome
3571-34-4, 89762-39-0

(2S)-dopachrome

Conditions
ConditionsYield
With water; mushroom tyrosinase Rate constant; phosphat buffer, ph 6.8;
Dopachrome
13520-94-0

Dopachrome

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
Rate constant;
With phosphate buffer at 30℃; Mechanism; Rate constant;96 % Chromat.
Dopachrome
13520-94-0

Dopachrome

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

5,6-dihydroxy-2-carboxyindole
4790-08-3

5,6-dihydroxy-2-carboxyindole

Conditions
ConditionsYield
With zinc diacetate In various solvent(s) Mechanism; Product distribution; Ambient temperature; rearrengament time;A 91 % Chromat.
B 2 % Chromat.
L-Tryptophan
73-22-3

L-Tryptophan

A

indole
120-72-9

indole

B

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

C

4,4'-Dihydroxybiphenyl
92-88-6

4,4'-Dihydroxybiphenyl

D

4-Hydroxyphenylpyruvic acid
156-39-8

4-Hydroxyphenylpyruvic acid

E

5,6,3-trihydroxyindole
3569-19-5

5,6,3-trihydroxyindole

F

anthranilic acid
118-92-3

anthranilic acid

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; oxygen; iron(II) sulfate; ascorbic acid In water at 30 - 32℃; for 2h; Product distribution; biomimetic hydroxylation, pH 6.7;
1(-)-tyrosine

1(-)-tyrosine

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With air; tyrosine ase from meal worms at 26 - 30℃; pH 6-6.5;
l(-)-3.4-dioxy-phenylalanine

l(-)-3.4-dioxy-phenylalanine

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With air; tyrosine ase from meal worms at 26 - 30℃; pH 6-6.5;
indole
120-72-9

indole

A

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

B

indole-2,3-dione
91-56-5

indole-2,3-dione

C

anthranilic acid
118-92-3

anthranilic acid

D

3-hydroxy pyrrolle-4,5-dicarboxylic acid

3-hydroxy pyrrolle-4,5-dicarboxylic acid

E

3-hydroxyanthranilic acid
548-93-6

3-hydroxyanthranilic acid

F

melanin

melanin

Conditions
ConditionsYield
With phosphate buffer; ethylenediaminetetraacetic acid; iron(II) sulfate; ascorbic acid In water; acetone at 37℃; for 2h; Product distribution; melanin formation under Udenfriend condition, oxygen atmosphere;
(2S)-dopachrome
3571-34-4, 89762-39-0

(2S)-dopachrome

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

Conditions
ConditionsYield
With potassium aluminum sulfate; HAc-NaAc buffer at 15℃; Kinetics;
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

5,6-bis (trimethylsilyloxy)-indole

5,6-bis (trimethylsilyloxy)-indole

Conditions
ConditionsYield
With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane71%
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

5,6-bis (trimethylsilyloxy)-indole

5,6-bis (trimethylsilyloxy)-indole

Conditions
ConditionsYield
In dichloromethane71%
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

di(1H-imidazol-2-yl)methanethione
88681-68-9

di(1H-imidazol-2-yl)methanethione

5,6-thiocarbonyldioxy indole
113370-16-4

5,6-thiocarbonyldioxy indole

Conditions
ConditionsYield
In water; Ethyl propionate; acetone; toluene63%
In di-isopropyl ether; water; acetone; toluene63%
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

glutathion
70-18-8

glutathion

4-S-glutathionyl-5,6-dihydroxyindole
103153-88-4

4-S-glutathionyl-5,6-dihydroxyindole

Conditions
ConditionsYield
With mushroom tyrosinase for 2h; 0.025 M phosphate buffer;48%
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

[1,4]naphthoquinone
130-15-4

[1,4]naphthoquinone

2-(5,6-Dihydroxy-1H-indol-3-yl)-[1,4]naphthoquinone
112097-20-8

2-(5,6-Dihydroxy-1H-indol-3-yl)-[1,4]naphthoquinone

Conditions
ConditionsYield
In acetic acid at 5℃;42%
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

4-[bis-(1H-5,6-dihydroxyindol-2-yl)methyl]-1,2-dihydroxybenzene

4-[bis-(1H-5,6-dihydroxyindol-2-yl)methyl]-1,2-dihydroxybenzene

Conditions
ConditionsYield
With phosphate buffer In water for 24h; pH=7.4;40%
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

acetic anhydride
108-24-7

acetic anhydride

A

2,3,7,8,12,13-hexaacetoxydiindolo[3,2-a:3',2'-c]carbazole

2,3,7,8,12,13-hexaacetoxydiindolo[3,2-a:3',2'-c]carbazole

B

2,3,6,7,11,12-hexaacetoxydiindolo[2,3-a:2',3'-c]carbazole

2,3,6,7,11,12-hexaacetoxydiindolo[2,3-a:2',3'-c]carbazole

Conditions
ConditionsYield
Stage #1: 1H-indole-5,6-diol With ammonium persulfate; phosphoric acid In water pH=1.4; Oxidation;
Stage #2: acetic anhydride With pyridine Acetylation;
A 29%
B 19%
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

acetic anhydride
108-24-7

acetic anhydride

A

2,3,7,8,12,13-hexaacetoxy-5,10,15-trimethyldiindolo[3,2-a:3',2'-c]carbazole

2,3,7,8,12,13-hexaacetoxy-5,10,15-trimethyldiindolo[3,2-a:3',2'-c]carbazole

B

2,3,6,7,11,12-hexaacetoxy-9,14,15-trimethyldiindolo[2,3-a:2',3'-c]carbazole

2,3,6,7,11,12-hexaacetoxy-9,14,15-trimethyldiindolo[2,3-a:2',3'-c]carbazole

Conditions
ConditionsYield
Stage #1: 1H-indole-5,6-diol With ammonium persulfate; phosphoric acid In water pH=1.4; Oxidation;
Stage #2: acetic anhydride With pyridine Acetylation;
A 26%
B 24%
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

acetic anhydride
108-24-7

acetic anhydride

A

5,5',6,6'-tetraacetoxy-2,7'-biindolyl
131248-80-1

5,5',6,6'-tetraacetoxy-2,7'-biindolyl

B

5,5',6,6'-tetraacetoxy-2,4'-biindolyl
131248-81-2

5,5',6,6'-tetraacetoxy-2,4'-biindolyl

Conditions
ConditionsYield
Stage #1: 1H-indole-5,6-diol With dihydrogen peroxide; horseradish peroxidase In phosphate buffer for 0.00694444h; pH=7.0;
Stage #2: acetic anhydride In pyridine at 20℃;
A 10%
B 15%
Stage #1: 1H-indole-5,6-diol With dihydrogen peroxide; horseradish peroxidase In phosphate buffer; acetone pH=7.0;
Stage #2: acetic anhydride In pyridine at 20℃;
A 13%
B 4%
2-thiouracil
141-90-2

2-thiouracil

1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

A

2-(5,6-Dihydroxy-1H-indol-2-ylsulfanyl)-3H-pyrimidin-4-one

2-(5,6-Dihydroxy-1H-indol-2-ylsulfanyl)-3H-pyrimidin-4-one

B

2-(5,6-Dihydroxy-1H-indol-3-ylsulfanyl)-3H-pyrimidin-4-one

2-(5,6-Dihydroxy-1H-indol-3-ylsulfanyl)-3H-pyrimidin-4-one

C

5,5',6,6'-tetrahydroxy-2,2'-bis[(4-hydroxypyrimidin-2-yl)thio]-4,4'-biindolyl

5,5',6,6'-tetrahydroxy-2,2'-bis[(4-hydroxypyrimidin-2-yl)thio]-4,4'-biindolyl

D

5,5',5",6,6',6"-hexahydroxy-2',3-bis[(4-hydroxypyrimidin-2-yl)thio]4,7':4',4"-terindolyl

5,5',5",6,6',6"-hexahydroxy-2',3-bis[(4-hydroxypyrimidin-2-yl)thio]4,7':4',4"-terindolyl

Conditions
ConditionsYield
With phosphate buffer pH 7.0; mushroom tyrosinase for 0.833333h; Product distribution; Mechanism; other melanin precursor;A 4%
B 5%
C 2%
D 9%
With phosphate buffer pH 7.0; mushroom tyrosinase for 0.833333h;A 4%
B 5%
C 2%
D 9%
1H-indole-5,6-diol
3131-52-0

1H-indole-5,6-diol

acetic anhydride
108-24-7

acetic anhydride

A

5,6-diacetoxy-N-acetyl-2-(5',6'-diacetoxyindol-3'-yl)indoline

5,6-diacetoxy-N-acetyl-2-(5',6'-diacetoxyindol-3'-yl)indoline

B

acetic acid 6-acetoxy-3-[2-(4,5-diacetoxy-2-acetylamino-phenyl)-1-(5,6-diacetoxy-1H-indol-3-yl)-ethyl]-1H-indol-5-yl ester

acetic acid 6-acetoxy-3-[2-(4,5-diacetoxy-2-acetylamino-phenyl)-1-(5,6-diacetoxy-1H-indol-3-yl)-ethyl]-1H-indol-5-yl ester

Conditions
ConditionsYield
Stage #1: 1H-indole-5,6-diol With ammonium persulfate; phosphoric acid In water for 0.000277778h; pH=1.4; Oxidation;
Stage #2: acetic anhydride With pyridine Acetylation;
A 9%
B 5%

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