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Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

Rasagiline Mesylate

Cas:161735-79-1

Min.Order:0

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Rasagiline mesylate Manufacturer/High quality/Best price/In stock

Cas:161735-79-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Rasagiline?Mesylate

Cas:161735-79-1

Min.Order:1

Negotiable

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 161735-79-1

Cas:161735-79-1

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Rasagiline mesylate 161735-79-1 GMP Manufacturer

Cas:161735-79-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

1. Superior quality 2.Competitive price 3. Good service 4. Stock availability all the year around 5. Flexible payment Appearance:white Storage:cool and dry Package:durm Application:api Transportation:by sea or by air Port:shandong

Rasagiline Mesylate CAS No.:161735-79-1

Cas:161735-79-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

R-(+)-Rasagiline mesylate

Cas:161735-79-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Rasagiline mesylate Basic information Product Name: Rasagiline mesylate Synonyms: RASAGILINE MESYLATE;(r)-n-2-propynyl-1-indanamine methanesulfonate;(1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-i

Rasagiline mesylate

Cas:161735-79-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Rasagiline mesylate

Cas:161735-79-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 161735-79-1 with best quality

Cas:161735-79-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot sale Rasagiline mesylate with best price and high quality

Cas:161735-79-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Rasagiline mesylate/ LIDE PHARMA- Factory supply / Best price

Cas:161735-79-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product Name Rasagiline mesylate CAS 161735-79-1 Molecular Formula C13H17NO3S Molecular Weight

Rasagiline mesylate

Cas:161735-79-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White to off-white crystalline solid Storage:Store in sealed

CAS: 161735-79-1 Sold Best Rasagiline Mesylate High Purity 99%

Cas:161735-79-1

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Rasagiline mesylate 161735-79-1

Cas:161735-79-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Rasagiline mesylate CAS 161735-79-1

Cas:161735-79-1

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antiparkinsonian drugs Rasagiline mesylate CAS:161735-79-1

Cas:161735-79-1

Min.Order:500 Gram

FOB Price: $1263.0 / 1334.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Rasagiline mesylate CAS:161735-79-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

Rasagiline mesylate CAS:161735-79-1

Cas:161735-79-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Rasagiline mesylate

Cas:161735-79-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 161735-79-1 Rasagiline mesylate

Cas:161735-79-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Rasagiline mesylate

Cas:161735-79-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detaile

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Rasagiline mesylate CAS NO.161735-79-1

Cas:161735-79-1

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Rasagiline mesylate

Cas:161735-79-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Rasagiline mesylate

Cas:161735-79-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Rasagiline mesylate 161735-79-1

Cas:161735-79-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Rasagiline mesylate

Cas:161735-79-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Rasagiline Mesylate

Cas:161735-79-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

TIANFU-CHEM - Rasagiline mesylateAppearance:Solid Storage:In Room Temperature Package:according to customers' requirements Application:Organic synthesis Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or ac

Rasagiline mesylate

Cas:161735-79-1

Min.Order:1 Gram

Negotiable

Type:Other

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Synthetic route

methanesulfonic acid
75-75-2

methanesulfonic acid

rasagiline
136236-51-6

rasagiline

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
In isopropyl alcohol for 1h; Reflux;98%
In toluene; acetonitrile at 40 - 80℃; Product distribution / selectivity;86.2%
In isopropyl alcohol at 5 - 10℃; for 0.5h;83%
methanesulfonic acid
75-75-2

methanesulfonic acid

(1R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine hemihydrate

(1R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine hemihydrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Stage #1: (1R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine hemihydrate With potassium carbonate In water pH=Ca. 10; Large scale;
Stage #2: methanesulfonic acid In isopropyl alcohol at 20℃; for 1.5h; Large scale;
92.6%
methanesulfonic acid
75-75-2

methanesulfonic acid

(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate

(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Stage #1: (1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate With sodium hydrogencarbonate In water; ethyl acetate at 20 - 25℃; Inert atmosphere;
Stage #2: methanesulfonic acid In isopropyl alcohol Reflux;
89%
methanesulfonic acid
75-75-2

methanesulfonic acid

rasagiline tartrate

rasagiline tartrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
In isopropyl alcohol at 5℃; for 1.5h; Reflux;83%
methanesulfonic acid
75-75-2

methanesulfonic acid

rasagiline tartrate

rasagiline tartrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
In isopropyl alcohol at 5 - 10℃; for 0.75h;83%
methanesulfonic acid
75-75-2

methanesulfonic acid

N-(2,3 dibromopropyl)-1-aminoindan
1166392-46-6

N-(2,3 dibromopropyl)-1-aminoindan

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Stage #1: N-(2,3 dibromopropyl)-1-aminoindan With potassium hydroxide In denaturated industrial spirit; water at 80 - 90℃; for 5h;
Stage #2: methanesulfonic acid In isopropyl alcohol at 25 - 30℃;
methanesulfonic acid
75-75-2

methanesulfonic acid

(R-(+)-N-propargyl-1-aminoindan)L-tartarate

(R-(+)-N-propargyl-1-aminoindan)L-tartarate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
In acetone for 0.75h; Product distribution / selectivity; Reflux;n/a
2,3-dihydro-1H-inden-1-amine
34698-41-4

2,3-dihydro-1H-inden-1-amine

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 24 h / 55 °C
2.1: isopropyl alcohol / 1.5 h / 25 - 30 °C / Reflux
3.1: ammonia / water / pH ~ 8.5 - 9
3.2: 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
2: 0.75 h / 25 - 65 °C
3: sodium hydroxide / water / 20 °C
4: acetone / 1 h / 25 - 35 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
2.1: 0.75 h / 25 - 65 °C
3.1: sodium hydroxide / water / 20 °C
4.1: hydrogen bromide / 0.5 h / 25 - 65 °C
5.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C
5.2: 0.5 h / 40 °C
View Scheme
Multi-step reaction with 4 steps
1: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
2: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
3: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
4: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
Multi-step reaction with 6 steps
1: ethanol; tert-butyl methyl ether / 20 °C
2: ethanol / 2.32 h / 79 °C
3: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C
4: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere
5: sodium hydroxide / toluene / 29 h / 30 °C
6: isopropyl alcohol / 1 h / 55 - 80 °C
View Scheme
methanesulfonic acid
75-75-2

methanesulfonic acid

(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate
1201685-18-8

(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Stage #1: (1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate With ammonia In water pH=~ 8.5 - 9;
Stage #2: methanesulfonic acid In acetone at 25 - 30℃; for 2h; Product distribution / selectivity;
inden-1-one
83-33-0

inden-1-one

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ethanol / 8 h / 25 - 30 °C
2.1: ethanol; sodium tetrahydroborate / 8 h / 25 - 30 °C
3.1: isopropyl alcohol / 1.5 h / 25 - 30 °C / Reflux
4.1: ammonia / water / pH ~ 8.5 - 9
4.2: 2 h / 25 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / tert-butyl methyl ether / 8 h
1.2: 1 h / -70 - -30 °C
2.1: diisobutylaluminium hydride / toluene; hexane / 1 h / -70 - -30 °C
2.2: 1 h / 20 °C
3.1: tert-butyl methyl ether / 21 h / 10 °C / Heating
4.1: sodium hydroxide
5.1: isopropyl alcohol / 16 h / 20 - 75 °C
View Scheme
Multi-step reaction with 6 steps
1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 70 - 75 °C
2: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave
3: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
4: 0.75 h / 25 - 65 °C
5: sodium hydroxide / water / 20 °C
6: acetone / 1 h / 25 - 35 °C
View Scheme
C21H33NO4Ti

C21H33NO4Ti

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ethanol; sodium tetrahydroborate / 8 h / 25 - 30 °C
2.1: isopropyl alcohol / 1.5 h / 25 - 30 °C / Reflux
3.1: ammonia / water / pH ~ 8.5 - 9
3.2: 2 h / 25 - 30 °C
View Scheme
rasagiline
136236-51-6

rasagiline

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogen bromide / 0.5 h / 25 - 65 °C
2.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C
2.2: 0.5 h / 40 °C
View Scheme
N-propargyl-1-aminoindan
1875-50-9

N-propargyl-1-aminoindan

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tert-butyl methyl ether / 21 h / 10 °C / Heating
2: sodium hydroxide
3: isopropyl alcohol / 16 h / 20 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1: 0.75 h / 25 - 65 °C
2: sodium hydroxide / water / 20 °C
3: acetone / 1 h / 25 - 35 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 0.75 h / 25 - 65 °C
2.1: sodium hydroxide / water / 20 °C
3.1: hydrogen bromide / 0.5 h / 25 - 65 °C
4.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C
4.2: 0.5 h / 40 °C
View Scheme
N-(2,3-dihydroinden-1-ylidene)prop-2-yn-1-amine
1227784-59-9

N-(2,3-dihydroinden-1-ylidene)prop-2-yn-1-amine

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / toluene; hexane / 1 h / -70 - -30 °C
1.2: 1 h / 20 °C
2.1: tert-butyl methyl ether / 21 h / 10 °C / Heating
3.1: sodium hydroxide
4.1: isopropyl alcohol / 16 h / 20 - 75 °C
View Scheme
R-(+)-N-propargyl-1-aminoindane L-(+)-mandelate
1309125-23-2

R-(+)-N-propargyl-1-aminoindane L-(+)-mandelate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide
2: isopropyl alcohol / 16 h / 20 - 75 °C
View Scheme
(R)-2,3-dihydro-1H-inden-1-amine hydrochloride

(R)-2,3-dihydro-1H-inden-1-amine hydrochloride

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.25 h / 15 - 20 °C
1.2: 2.75 h / 15 - 20 °C
2.1: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 0.58 h / 20 °C / Ice bath
2.1: caesium carbonate / acetonitrile / 0.17 h / 30 - 35 °C
2.2: 4 h / 30 - 35 °C
3.1: potassium hydroxide / water; methanol / 30 - 35 °C
4.1: isopropyl alcohol / 20 - 60 °C
4.2: 0.42 h / 20 - 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.25 h / 15 - 20 °C
1.2: 2.75 h / 15 - 20 °C
2.1: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / toluene / 29 h / 30 °C
2: isopropyl alcohol / 1 h / 55 - 80 °C
View Scheme
N-trifluoroacetyl-(R)-1-aminoindan
155666-94-7

N-trifluoroacetyl-(R)-1-aminoindan

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: caesium carbonate / acetonitrile / 0.17 h / 30 - 35 °C
1.2: 4 h / 30 - 35 °C
2.1: potassium hydroxide / water; methanol / 30 - 35 °C
3.1: isopropyl alcohol / 20 - 60 °C
3.2: 0.42 h / 20 - 60 °C
View Scheme
Multi-step reaction with 3 steps
1: caesium carbonate / acetonitrile; toluene / 30 - 35 °C
2: potassium hydroxide; water / methanol / 0.5 h / 30 - 35 °C
3: isopropyl alcohol / 50 - 60 °C
View Scheme
methanesulfonic acid
75-75-2

methanesulfonic acid

(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide
694436-33-4

(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Stage #1: (1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide With sodium hydroxide In ethyl acetate at 65℃; for 4h;
Stage #2: methanesulfonic acid In ethyl acetate at 40℃; for 0.5h;
rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave
2: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
3: 0.75 h / 25 - 65 °C
4: sodium hydroxide / water / 20 °C
5: acetone / 1 h / 25 - 35 °C
View Scheme
Multi-step reaction with 6 steps
1.1: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave
2.1: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
3.1: 0.75 h / 25 - 65 °C
4.1: sodium hydroxide / water / 20 °C
5.1: hydrogen bromide / 0.5 h / 25 - 65 °C
6.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C
6.2: 0.5 h / 40 °C
View Scheme
Multi-step reaction with 5 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 70 °C
2: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
3: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
4: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
5: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
Multi-step reaction with 7 steps
1: ammonia; hydrogen / methanol / 20 h / 42 °C / 2625.26 Torr
2: ethanol; tert-butyl methyl ether / 20 °C
3: ethanol / 2.32 h / 79 °C
4: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C
5: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere
6: sodium hydroxide / toluene / 29 h / 30 °C
7: isopropyl alcohol / 1 h / 55 - 80 °C
View Scheme
di-(R-(+)-N-propargyl-1-aminoindan) L-tartrate

di-(R-(+)-N-propargyl-1-aminoindan) L-tartrate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 20 °C
2.1: hydrogen bromide / 0.5 h / 25 - 65 °C
3.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C
3.2: 0.5 h / 40 °C
View Scheme
N-[(1R)-2,3-dihydro-1H-inden-1-yl]-2-methoxyacetamide

N-[(1R)-2,3-dihydro-1H-inden-1-yl]-2-methoxyacetamide

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
2: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
3: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Pd/AlO(OH) / toluene / 6 h / 70 °C / Inert atmosphere; Schlenk technique
2: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
3: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
4: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
5: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
3-Phenylpropionic acid
501-52-0

3-Phenylpropionic acid

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: polyphosphoric acid / 0.5 h / 90 °C
2: hydroxylamine hydrochloride / ethanol; water / 0.75 h / Reflux
3: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 70 °C
4: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
5: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
6: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
7: isopropyl alcohol / 0.5 h / 5 - 10 °C
View Scheme
2,3-dihydro-1H-inden-1-yl-acetate
26452-98-2

2,3-dihydro-1H-inden-1-yl-acetate

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Candida rugosa lipase / tetrahydrofuran; aq. phosphate buffer / 24 h / 30 °C / pH 7 / Resolution of racemate; Enzymatic reaction
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere
3: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
4: potassium carbonate / acetonitrile / 16 h / 60 °C
5: isopropyl alcohol / 1 h / Reflux
View Scheme
1-Indanol
6351-10-6

1-Indanol

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Thermomyces lanuginosus lipase / hexane / 0.25 h / 35 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere
3: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
4: potassium carbonate / acetonitrile / 16 h / 60 °C
5: isopropyl alcohol / 1 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: pseudomonas fluorescens lipase / toluene / 6 h / 30 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere
3: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
4: potassium carbonate / acetonitrile / 16 h / 60 °C
5: isopropyl alcohol / 1 h / Reflux
View Scheme
Multi-step reaction with 6 steps
1: dmap / dichloromethane / 4 h / 20 °C
2: Candida rugosa lipase / tetrahydrofuran; aq. phosphate buffer / 24 h / 30 °C / pH 7 / Resolution of racemate; Enzymatic reaction
3: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere
4: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
5: potassium carbonate / acetonitrile / 16 h / 60 °C
6: isopropyl alcohol / 1 h / Reflux
View Scheme
(S)-indanol
25501-32-0

(S)-indanol

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere
2: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
3: potassium carbonate / acetonitrile / 16 h / 60 °C
4: isopropyl alcohol / 1 h / Reflux
View Scheme
(R)-(+)-1-azidoindan

(R)-(+)-1-azidoindan

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
2: potassium carbonate / acetonitrile / 16 h / 60 °C
3: isopropyl alcohol / 1 h / Reflux
View Scheme
(R)-1-Aminoindane
10277-74-4

(R)-1-Aminoindane

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 16 h / 60 °C
2: isopropyl alcohol / 1 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere
2: sodium hydroxide / toluene / 29 h / 30 °C
3: isopropyl alcohol / 1 h / 55 - 80 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 16 h / 60 °C
2: isopropyl alcohol / 1 h / 70 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 15 - 20 °C / Inert atmosphere
2: triphenylsilyl radical; 2-Chlorobenzeneboronic acid / toluene / 24 h / 10 - 15 °C / Inert atmosphere
3: isopropyl alcohol / 1 h / 70 - 75 °C
View Scheme
(R)-1-aminoindan (S)-N-acetyl-L-glutaminate (2:1)

(R)-1-aminoindan (S)-N-acetyl-L-glutaminate (2:1)

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C
2: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere
3: sodium hydroxide / toluene / 29 h / 30 °C
4: isopropyl alcohol / 1 h / 55 - 80 °C
View Scheme
rasagiline mesylate
161735-79-1

rasagiline mesylate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In water at 3 - 5℃; for 1h; pH=7.5 - 11; Product distribution / selectivity;91.6%
With sodium hydroxide In water at 3 - 5℃; pH=11;91.6%
With sodium hydroxide In water; toluene pH=~ 14;
With sodium hydroxide In water; toluene pH=14;
(R-(+)-N-propargyl-1-aminoindan)L-tartarate

(R-(+)-N-propargyl-1-aminoindan)L-tartarate

rasagiline mesylate
161735-79-1

rasagiline mesylate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 40 - 50℃; pH=14; Product distribution / selectivity;

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