KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li
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Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
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inquiryRasagiline mesylate Basic information Product Name: Rasagiline mesylate Synonyms: RASAGILINE MESYLATE;(r)-n-2-propynyl-1-indanamine methanesulfonate;(1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-i
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name Rasagiline mesylate CAS 161735-79-1 Molecular Formula C13H17NO3S Molecular Weight
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inquiryRasagiline mesylate CAS:161735-79-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryTIANFU-CHEM - Rasagiline mesylateAppearance:Solid Storage:In Room Temperature Package:according to customers' requirements Application:Organic synthesis Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or ac
Conditions | Yield |
---|---|
In isopropyl alcohol for 1h; Reflux; | 98% |
In toluene; acetonitrile at 40 - 80℃; Product distribution / selectivity; | 86.2% |
In isopropyl alcohol at 5 - 10℃; for 0.5h; | 83% |
methanesulfonic acid
rasagiline mesylate
Conditions | Yield |
---|---|
Stage #1: (1R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine hemihydrate With potassium carbonate In water pH=Ca. 10; Large scale; Stage #2: methanesulfonic acid In isopropyl alcohol at 20℃; for 1.5h; Large scale; | 92.6% |
methanesulfonic acid
rasagiline mesylate
Conditions | Yield |
---|---|
Stage #1: (1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate With sodium hydrogencarbonate In water; ethyl acetate at 20 - 25℃; Inert atmosphere; Stage #2: methanesulfonic acid In isopropyl alcohol Reflux; | 89% |
Conditions | Yield |
---|---|
In isopropyl alcohol at 5℃; for 1.5h; Reflux; | 83% |
Conditions | Yield |
---|---|
In isopropyl alcohol at 5 - 10℃; for 0.75h; | 83% |
methanesulfonic acid
N-(2,3 dibromopropyl)-1-aminoindan
rasagiline mesylate
Conditions | Yield |
---|---|
Stage #1: N-(2,3 dibromopropyl)-1-aminoindan With potassium hydroxide In denaturated industrial spirit; water at 80 - 90℃; for 5h; Stage #2: methanesulfonic acid In isopropyl alcohol at 25 - 30℃; |
methanesulfonic acid
rasagiline mesylate
Conditions | Yield |
---|---|
In acetone for 0.75h; Product distribution / selectivity; Reflux; | n/a |
2,3-dihydro-1H-inden-1-amine
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 24 h / 55 °C 2.1: isopropyl alcohol / 1.5 h / 25 - 30 °C / Reflux 3.1: ammonia / water / pH ~ 8.5 - 9 3.2: 2 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 4 steps 1: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C 2: 0.75 h / 25 - 65 °C 3: sodium hydroxide / water / 20 °C 4: acetone / 1 h / 25 - 35 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C 2.1: 0.75 h / 25 - 65 °C 3.1: sodium hydroxide / water / 20 °C 4.1: hydrogen bromide / 0.5 h / 25 - 65 °C 5.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C 5.2: 0.5 h / 40 °C View Scheme | |
Multi-step reaction with 4 steps 1: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction 2: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux 3: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux 4: isopropyl alcohol / 0.5 h / 5 - 10 °C View Scheme | |
Multi-step reaction with 6 steps 1: ethanol; tert-butyl methyl ether / 20 °C 2: ethanol / 2.32 h / 79 °C 3: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C 4: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere 5: sodium hydroxide / toluene / 29 h / 30 °C 6: isopropyl alcohol / 1 h / 55 - 80 °C View Scheme |
methanesulfonic acid
(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate
rasagiline mesylate
Conditions | Yield |
---|---|
Stage #1: (1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate With ammonia In water pH=~ 8.5 - 9; Stage #2: methanesulfonic acid In acetone at 25 - 30℃; for 2h; Product distribution / selectivity; |
inden-1-one
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: ethanol / 8 h / 25 - 30 °C 2.1: ethanol; sodium tetrahydroborate / 8 h / 25 - 30 °C 3.1: isopropyl alcohol / 1.5 h / 25 - 30 °C / Reflux 4.1: ammonia / water / pH ~ 8.5 - 9 4.2: 2 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid / tert-butyl methyl ether / 8 h 1.2: 1 h / -70 - -30 °C 2.1: diisobutylaluminium hydride / toluene; hexane / 1 h / -70 - -30 °C 2.2: 1 h / 20 °C 3.1: tert-butyl methyl ether / 21 h / 10 °C / Heating 4.1: sodium hydroxide 5.1: isopropyl alcohol / 16 h / 20 - 75 °C View Scheme | |
Multi-step reaction with 6 steps 1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 70 - 75 °C 2: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave 3: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C 4: 0.75 h / 25 - 65 °C 5: sodium hydroxide / water / 20 °C 6: acetone / 1 h / 25 - 35 °C View Scheme |
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ethanol; sodium tetrahydroborate / 8 h / 25 - 30 °C 2.1: isopropyl alcohol / 1.5 h / 25 - 30 °C / Reflux 3.1: ammonia / water / pH ~ 8.5 - 9 3.2: 2 h / 25 - 30 °C View Scheme |
rasagiline
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogen bromide / 0.5 h / 25 - 65 °C 2.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C 2.2: 0.5 h / 40 °C View Scheme |
N-propargyl-1-aminoindan
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tert-butyl methyl ether / 21 h / 10 °C / Heating 2: sodium hydroxide 3: isopropyl alcohol / 16 h / 20 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: 0.75 h / 25 - 65 °C 2: sodium hydroxide / water / 20 °C 3: acetone / 1 h / 25 - 35 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 0.75 h / 25 - 65 °C 2.1: sodium hydroxide / water / 20 °C 3.1: hydrogen bromide / 0.5 h / 25 - 65 °C 4.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C 4.2: 0.5 h / 40 °C View Scheme |
N-(2,3-dihydroinden-1-ylidene)prop-2-yn-1-amine
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: diisobutylaluminium hydride / toluene; hexane / 1 h / -70 - -30 °C 1.2: 1 h / 20 °C 2.1: tert-butyl methyl ether / 21 h / 10 °C / Heating 3.1: sodium hydroxide 4.1: isopropyl alcohol / 16 h / 20 - 75 °C View Scheme |
R-(+)-N-propargyl-1-aminoindane L-(+)-mandelate
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide 2: isopropyl alcohol / 16 h / 20 - 75 °C View Scheme |
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.25 h / 15 - 20 °C 1.2: 2.75 h / 15 - 20 °C 2.1: isopropyl alcohol / 0.5 h / 5 - 10 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: pyridine / dichloromethane / 0.58 h / 20 °C / Ice bath 2.1: caesium carbonate / acetonitrile / 0.17 h / 30 - 35 °C 2.2: 4 h / 30 - 35 °C 3.1: potassium hydroxide / water; methanol / 30 - 35 °C 4.1: isopropyl alcohol / 20 - 60 °C 4.2: 0.42 h / 20 - 60 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide; tetrabutylammomium bromide / water / 0.25 h / 15 - 20 °C 1.2: 2.75 h / 15 - 20 °C 2.1: isopropyl alcohol / 0.5 h / 5 - 10 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / toluene / 29 h / 30 °C 2: isopropyl alcohol / 1 h / 55 - 80 °C View Scheme |
N-trifluoroacetyl-(R)-1-aminoindan
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: caesium carbonate / acetonitrile / 0.17 h / 30 - 35 °C 1.2: 4 h / 30 - 35 °C 2.1: potassium hydroxide / water; methanol / 30 - 35 °C 3.1: isopropyl alcohol / 20 - 60 °C 3.2: 0.42 h / 20 - 60 °C View Scheme | |
Multi-step reaction with 3 steps 1: caesium carbonate / acetonitrile; toluene / 30 - 35 °C 2: potassium hydroxide; water / methanol / 0.5 h / 30 - 35 °C 3: isopropyl alcohol / 50 - 60 °C View Scheme |
methanesulfonic acid
(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide
rasagiline mesylate
Conditions | Yield |
---|---|
Stage #1: (1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide With sodium hydroxide In ethyl acetate at 65℃; for 4h; Stage #2: methanesulfonic acid In ethyl acetate at 40℃; for 0.5h; |
indan-1-one oxime
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave 2: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C 3: 0.75 h / 25 - 65 °C 4: sodium hydroxide / water / 20 °C 5: acetone / 1 h / 25 - 35 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave 2.1: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C 3.1: 0.75 h / 25 - 65 °C 4.1: sodium hydroxide / water / 20 °C 5.1: hydrogen bromide / 0.5 h / 25 - 65 °C 6.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C 6.2: 0.5 h / 40 °C View Scheme | |
Multi-step reaction with 5 steps 1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 70 °C 2: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction 3: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux 4: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux 5: isopropyl alcohol / 0.5 h / 5 - 10 °C View Scheme | |
Multi-step reaction with 7 steps 1: ammonia; hydrogen / methanol / 20 h / 42 °C / 2625.26 Torr 2: ethanol; tert-butyl methyl ether / 20 °C 3: ethanol / 2.32 h / 79 °C 4: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C 5: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere 6: sodium hydroxide / toluene / 29 h / 30 °C 7: isopropyl alcohol / 1 h / 55 - 80 °C View Scheme |
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / water / 20 °C 2.1: hydrogen bromide / 0.5 h / 25 - 65 °C 3.1: sodium hydroxide / ethyl acetate / 4 h / 65 °C 3.2: 0.5 h / 40 °C View Scheme |
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux 2: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux 3: isopropyl alcohol / 0.5 h / 5 - 10 °C View Scheme |
(S)-1-Aminoindane
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Pd/AlO(OH) / toluene / 6 h / 70 °C / Inert atmosphere; Schlenk technique 2: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction 3: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux 4: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux 5: isopropyl alcohol / 0.5 h / 5 - 10 °C View Scheme |
3-Phenylpropionic acid
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: polyphosphoric acid / 0.5 h / 90 °C 2: hydroxylamine hydrochloride / ethanol; water / 0.75 h / Reflux 3: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 70 °C 4: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction 5: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux 6: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux 7: isopropyl alcohol / 0.5 h / 5 - 10 °C View Scheme |
2,3-dihydro-1H-inden-1-yl-acetate
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Candida rugosa lipase / tetrahydrofuran; aq. phosphate buffer / 24 h / 30 °C / pH 7 / Resolution of racemate; Enzymatic reaction 2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere 3: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C 4: potassium carbonate / acetonitrile / 16 h / 60 °C 5: isopropyl alcohol / 1 h / Reflux View Scheme |
1-Indanol
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Thermomyces lanuginosus lipase / hexane / 0.25 h / 35 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction 2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere 3: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C 4: potassium carbonate / acetonitrile / 16 h / 60 °C 5: isopropyl alcohol / 1 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1: pseudomonas fluorescens lipase / toluene / 6 h / 30 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction 2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere 3: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C 4: potassium carbonate / acetonitrile / 16 h / 60 °C 5: isopropyl alcohol / 1 h / Reflux View Scheme | |
Multi-step reaction with 6 steps 1: dmap / dichloromethane / 4 h / 20 °C 2: Candida rugosa lipase / tetrahydrofuran; aq. phosphate buffer / 24 h / 30 °C / pH 7 / Resolution of racemate; Enzymatic reaction 3: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere 4: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C 5: potassium carbonate / acetonitrile / 16 h / 60 °C 6: isopropyl alcohol / 1 h / Reflux View Scheme |
(S)-indanol
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 22 h / 0 - 20 °C / Inert atmosphere 2: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C 3: potassium carbonate / acetonitrile / 16 h / 60 °C 4: isopropyl alcohol / 1 h / Reflux View Scheme |
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triphenylphosphine; potassium hydroxide; water / tetrahydrofuran / 24 h / 20 °C 2: potassium carbonate / acetonitrile / 16 h / 60 °C 3: isopropyl alcohol / 1 h / Reflux View Scheme |
(R)-1-Aminoindane
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / acetonitrile / 16 h / 60 °C 2: isopropyl alcohol / 1 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere 2: sodium hydroxide / toluene / 29 h / 30 °C 3: isopropyl alcohol / 1 h / 55 - 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / acetonitrile / 16 h / 60 °C 2: isopropyl alcohol / 1 h / 70 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 15 - 20 °C / Inert atmosphere 2: triphenylsilyl radical; 2-Chlorobenzeneboronic acid / toluene / 24 h / 10 - 15 °C / Inert atmosphere 3: isopropyl alcohol / 1 h / 70 - 75 °C View Scheme |
rasagiline mesylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C 2: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere 3: sodium hydroxide / toluene / 29 h / 30 °C 4: isopropyl alcohol / 1 h / 55 - 80 °C View Scheme |
rasagiline mesylate
rasagiline
Conditions | Yield |
---|---|
With sodium hydroxide In water at 3 - 5℃; for 1h; pH=7.5 - 11; Product distribution / selectivity; | 91.6% |
With sodium hydroxide In water at 3 - 5℃; pH=11; | 91.6% |
With sodium hydroxide In water; toluene pH=~ 14; | |
With sodium hydroxide In water; toluene pH=14; |
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene at 40 - 50℃; pH=14; Product distribution / selectivity; |
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