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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Rasagiline

Cas:136236-51-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Rasagiline 136236-51-6 GMP Manufacturer

Cas:136236-51-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Rasagiline

Cas:136236-51-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine

Cas:136236-51-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 136236-51-6 with competitive price

Cas:136236-51-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Rasagiline CAS:136236-51-6

Cas:136236-51-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Inden-1-amine,2,3-dihydro-N-2-propyn-1-yl-, (1R)- 136236-51-6

Cas:136236-51-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Rasagiline CAS 136236-51-6

Cas:136236-51-6

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

supply best quality and price CAS 136236-51-6 rasagiline

Cas:136236-51-6

Min.Order:1 Gram

FOB Price: $10.0 / 20.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Rasagiline CAS:136236-51-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Rasagiline CAS:136236-51-6

Cas:136236-51-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Inden-1-amine,2,3-dihydro-N-2-propyn-1-yl-, (1R)-

Cas:136236-51-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Inden-1-amine,2,3-dihydro-N-2-propyn-1-yl-, (1R)-

Cas:136236-51-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:NA Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:It is an important raw material and

Rasagiline

Cas:136236-51-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Rasagiline Active Pharmaceutical Ingredients For Parkinson's disease 136236-51-6

Cas:136236-51-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1H-Inden-1-amine,2,3-dihydro-N-2-propyn-1-yl-, (1R)-

Cas:136236-51-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Rasagiline manufacturer

Cas:136236-51-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Rasagiline

Cas:136236-51-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Rasagiline

Cas:136236-51-6

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

1H-Inden-1-amine,2,3-dihydro-N-2-propyn-1-yl-, (1R)- (R)-2,3-DIHYDRO-N-2-PROPYNYL-1H-INDEN-1-AMINE;Rasagiline -13C3;Rasagiline;(R)-N-2-Propynyl-1-indanamine;1H-Inden-1-amine, 2,3-dihydro-N-2-propynyl-, (1R);1-Indanamine, N-2-propynyl-, (R)-;Unii-

136236-51-6

Cas:136236-51-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Rasagiline Active Pharmaceutical Ingredients For Parkinson's disease 136236-51-6

Cas:136236-51-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

(R)-N-(2-Propynyl)-2,3-dihydroinden-1-amine

Cas:136236-51-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Rasagiline

Cas:136236-51-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Rasagiline Synonyms: (R)-2,3-DIHYDRO-N-2-PROPYNYL-1H-INDEN-1-AMINE;Rasagiline -13C3;Rasagiline;(R)-N-2-Propynyl-1-indanamine;1H-Inden-1-amine, 2,3-dihydro-N-2-propynyl-, (1R);1-Indanamine, N-2-propynyl-, (R)-;Unii-003N66ts6t;(R)-N

Rasagiline

Cas:136236-51-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Rasagiline

Cas:136236-51-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Rasagiline Active Pharmaceutical Ingredients For Parkinson's disease 136236-51-6

Cas:136236-51-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Rasagiline(NaOH)

Cas:136236-51-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Cas no.136236-51-6 98% Rasagiline

Cas:136236-51-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Rasagiline Active Pharmaceutical Ingredients For Parkinson's disease 136236-51-6

Cas:136236-51-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:SHANGHAI;BEIJING

Rasagiline(artaric acid)

Cas:136236-51-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

(R-(+)-N-propargyl-1-aminoindan)L-tartarate

(R-(+)-N-propargyl-1-aminoindan)L-tartarate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 45℃; for 0.25h; pH=13 - 14;96%
With sodium hydroxide In water; toluene at 45℃; for 0.25h; Product distribution / selectivity;92%
With sodium hydroxide In water pH=11.98; Product distribution / selectivity;n/a
(R)-tert-butyl 2,3-dihydro-1H-inden-1-yl(prop-2-ynyl)carbamate
1224439-21-7

(R)-tert-butyl 2,3-dihydro-1H-inden-1-yl(prop-2-ynyl)carbamate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Stage #1: (R)-tert-butyl 2,3-dihydro-1H-inden-1-yl(prop-2-ynyl)carbamate With hydrogenchloride; water In 1,4-dioxane at 20℃; for 0.5h; Inert atmosphere;
Stage #2: With sodium hydrogencarbonate In 1,4-dioxane; water Inert atmosphere;
95%
rasagiline mesylate
161735-79-1

rasagiline mesylate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In water at 3 - 5℃; for 1h; pH=7.5 - 11; Product distribution / selectivity;91.6%
With sodium hydroxide In water at 3 - 5℃; pH=11;91.6%
With sodium hydroxide In water; toluene pH=~ 14;
With sodium hydroxide In water; toluene pH=14;
R-(+)-N-propargyl-1-aminoindane L-(+)-mandelate
1309125-23-2

R-(+)-N-propargyl-1-aminoindane L-(+)-mandelate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide90%
(R)-N-(2-chloroallyl)-2,3-dihydro-1H-inden-1-amine
1175018-73-1

(R)-N-(2-chloroallyl)-2,3-dihydro-1H-inden-1-amine

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium t-butanolate In ISOPROPYLAMIDE at 0 - 5℃; for 2.16667h; Product distribution / selectivity; Inert atmosphere;82%
(R)-1-Aminoindane
10277-74-4

(R)-1-Aminoindane

2-propynyl chloride
624-65-7

2-propynyl chloride

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 60℃; for 16h;79%
With potassium carbonate In acetonitrile at 60℃; for 16h;
propargyl benzenesulfonate
6165-75-9

propargyl benzenesulfonate

(R)-1-Aminoindane
10277-74-4

(R)-1-Aminoindane

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 30 - 50℃; Product distribution / selectivity;74.56%
propargyl benzenesulfonate
6165-75-9

propargyl benzenesulfonate

(R)-2,3-dihydro-1H-inden-1-amine hydrochloride

(R)-2,3-dihydro-1H-inden-1-amine hydrochloride

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In toluene at 30℃; for 29h;65.8%
With sodium hydroxide In toluene at 30℃; for 29h;65.8%
Stage #1: (R)-2,3-dihydro-1H-inden-1-amine hydrochloride With tetrabutylammomium bromide; sodium hydroxide In water at 15 - 20℃; for 0.25h;
Stage #2: propargyl benzenesulfonate In water at 15 - 20℃; for 2.75h;
Stage #1: (R)-2,3-dihydro-1H-inden-1-amine hydrochloride With tetrabutylammomium bromide; sodium hydroxide In water at 15 - 20℃; for 0.25h;
Stage #2: propargyl benzenesulfonate In water at 15 - 20℃; for 2.75h;
81.0 g
(R)-N-indan-1-yl-4-nitro-N-prop-2-ynyl-benzenesulfonamide
915797-28-3

(R)-N-indan-1-yl-4-nitro-N-prop-2-ynyl-benzenesulfonamide

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol64%
(R)-1-Aminoindane
10277-74-4

(R)-1-Aminoindane

propargyl bromide
106-96-7

propargyl bromide

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 30℃; for 12h; Reflux;59.7%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 80℃; for 0.166667h; Flow reactor;58%
With triethylamine In tetrahydrofuran at 50℃;
INDANE
496-11-7

INDANE

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Rh2[(S)-(adamantan-1-yl)(tetrachlorophthalimido)CHCOO]4; PhI(OAc)2 / various solvent(s) / 3 h / 23 °C
2: 75 percent / K2CO3
3: 64 percent / DBU; HSC2H4OH
View Scheme
(R)-N-indan-1-yl-4-nitrobenzenesulfonamide
217640-41-0

(R)-N-indan-1-yl-4-nitrobenzenesulfonamide

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / K2CO3
2: 64 percent / DBU; HSC2H4OH
View Scheme
C10H12O3S

C10H12O3S

Propargylamine
2450-71-7

Propargylamine

A

rasagiline
136236-51-6

rasagiline

B

N-Propargyl-1(S)-aminoindan

N-Propargyl-1(S)-aminoindan

Conditions
ConditionsYield
In dichloromethane at -29 - 20℃;A n/a
B n/a
di-(R-(+)-N-propargyl-1-aminoindan) L-tartrate

di-(R-(+)-N-propargyl-1-aminoindan) L-tartrate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In water; toluene
With sodium hydroxide In water at 20℃;
(R-(+)-N-propargyl-1-aminoindan)L-tartarate

(R-(+)-N-propargyl-1-aminoindan)L-tartarate

rasagiline mesylate
161735-79-1

rasagiline mesylate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 40 - 50℃; pH=14; Product distribution / selectivity;
R-(-)-N-(2,3 dibromopropyl)-1-aminoindan
1166392-44-4

R-(-)-N-(2,3 dibromopropyl)-1-aminoindan

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With potassium hydroxide In denaturated industrial spirit; water at 80 - 90℃; for 5h;
propargyl p-toluenesulfonate
6165-76-0

propargyl p-toluenesulfonate

(R)-1-Aminoindane
10277-74-4

(R)-1-Aminoindane

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Stage #1: (R)-1-Aminoindane With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 0 - 5℃;
Stage #2: propargyl p-toluenesulfonate In tetrahydrofuran at 0 - 25℃;
Stage #3: With sodium hydroxide In water for 0.25h;
Stage #1: (R)-1-Aminoindane With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 0 - 5℃;
Stage #2: propargyl p-toluenesulfonate In tetrahydrofuran at 15 - 20℃;
2,3-dihydro-1H-inden-1-amine
34698-41-4

2,3-dihydro-1H-inden-1-amine

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / toluene; water / 4.95 h / 20 - 47 °C / Inert atmosphere; Industry scale
2: isopropyl alcohol; water / 25 °C / Reflux; Inert atmosphere; Industry scale; Resolution of racemate
3: sodium hydroxide / toluene; water / 40 - 47 °C / Industry scale; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
2: 0.75 h / 25 - 65 °C
3: sodium hydroxide / water / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
2: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
3: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1: ethanol; tert-butyl methyl ether / 20 °C
2: ethanol / 2.32 h / 79 °C
3: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C
4: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere
5: sodium hydroxide / toluene / 29 h / 30 °C
View Scheme
(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate

(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine L-(+)-tartrate

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 40 - 47℃; Industry scale; Inert atmosphere;
inden-1-one
83-33-0

inden-1-one

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / tert-butyl methyl ether / 8 h
1.2: 1 h / -70 - -30 °C
2.1: diisobutylaluminium hydride / toluene; hexane / 1 h / -70 - -30 °C
2.2: 1 h / 20 °C
3.1: tert-butyl methyl ether / 21 h / 10 °C / Heating
4.1: sodium hydroxide
View Scheme
Multi-step reaction with 5 steps
1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 70 - 75 °C
2: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave
3: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
4: 0.75 h / 25 - 65 °C
5: sodium hydroxide / water / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: hydroxylamine hydrochloride / ethanol; water / 0.75 h / Reflux
2: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 70 °C
3: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
4: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
5: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
View Scheme
N-(2,3-dihydroinden-1-ylidene)prop-2-yn-1-amine
1227784-59-9

N-(2,3-dihydroinden-1-ylidene)prop-2-yn-1-amine

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisobutylaluminium hydride / toluene; hexane / 1 h / -70 - -30 °C
1.2: 1 h / 20 °C
2.1: tert-butyl methyl ether / 21 h / 10 °C / Heating
3.1: sodium hydroxide
View Scheme
N-trifluoroacetyl-(R)-1-aminoindan
155666-94-7

N-trifluoroacetyl-(R)-1-aminoindan

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: caesium carbonate / acetonitrile / 0.17 h / 30 - 35 °C
1.2: 4 h / 30 - 35 °C
2.1: potassium hydroxide / water; methanol / 30 - 35 °C
View Scheme
Multi-step reaction with 2 steps
1: caesium carbonate / acetonitrile; toluene / 30 - 35 °C
2: potassium hydroxide; water / methanol / 0.5 h / 30 - 35 °C
View Scheme
(R)-2,3-dihydro-1H-inden-1-amine hydrochloride

(R)-2,3-dihydro-1H-inden-1-amine hydrochloride

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridine / dichloromethane / 0.58 h / 20 °C / Ice bath
2.1: caesium carbonate / acetonitrile / 0.17 h / 30 - 35 °C
2.2: 4 h / 30 - 35 °C
3.1: potassium hydroxide / water; methanol / 30 - 35 °C
View Scheme
C14H12F3NO
1378030-60-4

C14H12F3NO

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
With potassium hydroxide In methanol; water at 30 - 35℃;
With water; potassium hydroxide In methanol at 30 - 35℃; for 0.5h;14.3 g
N-propargyl-1-aminoindan
1875-50-9

N-propargyl-1-aminoindan

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 0.75 h / 25 - 65 °C
2: sodium hydroxide / water / 20 °C
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave
2: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
3: 0.75 h / 25 - 65 °C
4: sodium hydroxide / water / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 70 °C
2: Candida antarctica lipase B; Pd/AlO(OH); potassium carbonate / toluene / 12 h / 50 °C / Resolution of racemate; Inert atmosphere; Schlenk technique; Enzymatic reaction
3: triethanolamine; sodium hydroxide / water / 6.25 h / 80 °C / Reflux
4: potassium carbonate / acetonitrile / 12 h / 30 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1: ammonia; hydrogen / methanol / 20 h / 42 °C / 2625.26 Torr
2: ethanol; tert-butyl methyl ether / 20 °C
3: ethanol / 2.32 h / 79 °C
4: sodium hydroxide / ethyl acetate / 0.5 h / 20 °C
5: hydrogenchloride / isopropyl alcohol / 0.5 h / 5 - 20 °C / Inert atmosphere
6: sodium hydroxide / toluene / 29 h / 30 °C
View Scheme
propargyl bromide
106-96-7

propargyl bromide

(R)-2,3-dihydro-1H-inden-1-amine hydrochloride

(R)-2,3-dihydro-1H-inden-1-amine hydrochloride

rasagiline
136236-51-6

rasagiline

Conditions
ConditionsYield
Stage #1: (R)-2,3-dihydro-1H-inden-1-amine hydrochloride With potassium carbonate In acetonitrile at 60 - 62℃; for 1h;
Stage #2: propargyl bromide In acetonitrile for 28h; Concentration; Time;
22 g
N-propargyl-1-aminoindan
1875-50-9

N-propargyl-1-aminoindan

A

rasagiline
136236-51-6

rasagiline

B

N-Propargyl-1(S)-aminoindan

N-Propargyl-1(S)-aminoindan

Conditions
ConditionsYield
With Chiralcel-OJ-H (4-methylbenzoate cellulose coated on silica) column In ethanol; hexane; diethylamine; isopropyl alcohol at 27℃; Temperature; Solvent; Resolution of racemate;
gluconic acid
526-95-4

gluconic acid

rasagiline
136236-51-6

rasagiline

R-(+)-N-propargyl-1-aminoindan gluconate
1204184-71-3

R-(+)-N-propargyl-1-aminoindan gluconate

Conditions
ConditionsYield
In ethanol; water for 2h; Product distribution / selectivity;100%
In water; isopropyl alcohol at 40℃; for 1h;
LACTIC ACID
849585-22-4

LACTIC ACID

rasagiline
136236-51-6

rasagiline

rasagiline DL-lactate
1260684-39-6

rasagiline DL-lactate

Conditions
ConditionsYield
In acetone for 2h;100%
propionic acid
802294-64-0

propionic acid

rasagiline
136236-51-6

rasagiline

rasagiline propanoate
1260684-10-3

rasagiline propanoate

Conditions
ConditionsYield
In di-isopropyl ether for 1.5h;100%
rasagiline
136236-51-6

rasagiline

valeric acid
109-52-4

valeric acid

rasagiline pentanoate
1260684-09-0

rasagiline pentanoate

Conditions
ConditionsYield
In di-isopropyl ether for 1.5h;100%
linoleic acid
60-33-3

linoleic acid

rasagiline
136236-51-6

rasagiline

rasagiline linoleate
1260684-08-9

rasagiline linoleate

Conditions
ConditionsYield
In acetone for 2h;100%
sodium docusate
577-11-7

sodium docusate

rasagiline
136236-51-6

rasagiline

rasagiline docusate
1260684-42-1

rasagiline docusate

Conditions
ConditionsYield
Stage #1: sodium docusate With hydrogenchloride In dichloromethane; water
Stage #2: rasagiline In acetone for 2h; Product distribution / selectivity;
100%
saccharin
81-07-2

saccharin

rasagiline
136236-51-6

rasagiline

rasagiline saccharinate
1260684-40-9

rasagiline saccharinate

Conditions
ConditionsYield
In acetone100%
In isopropyl alcohol at 20℃; Cooling with ice;63%
sodium 4-dodecylbenzenesulfonate
2211-98-5

sodium 4-dodecylbenzenesulfonate

rasagiline
136236-51-6

rasagiline

rasagiline 4-dodecylbenzenesulfonate
1260684-46-5

rasagiline 4-dodecylbenzenesulfonate

Conditions
ConditionsYield
With acetic acid In water; acetone for 2h;100%
benzenesulfonic acid
98-11-3

benzenesulfonic acid

rasagiline
136236-51-6

rasagiline

R-(+)-N-propargyl-1-aminoindan besylate
1201908-33-9

R-(+)-N-propargyl-1-aminoindan besylate

Conditions
ConditionsYield
In toluene at 20℃; Product distribution / selectivity;99.5%
In ethyl acetate at 10 - 25℃; for 3h; Product distribution / selectivity;
rasagiline
136236-51-6

rasagiline

[14C]-Rasagiline hydrochloride
136236-50-5

[14C]-Rasagiline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In tert-butyl methyl ether at 10 - 15℃; for 0.5h; Product distribution / selectivity;99%
With hydrogenchloride In diethyl ether Product distribution / selectivity; Cooling with ice;
With hydrogenchloride In water; isopropyl alcohol at 40℃; for 2h; Product distribution / selectivity;
hexanoic acid
142-62-1

hexanoic acid

rasagiline
136236-51-6

rasagiline

rasagiline hexanoate
1260684-13-6

rasagiline hexanoate

Conditions
ConditionsYield
In di-isopropyl ether for 1.5h; Inert atmosphere;99%
Octanoic acid
124-07-2

Octanoic acid

rasagiline
136236-51-6

rasagiline

rasagiline octanoate
1260684-12-5

rasagiline octanoate

Conditions
ConditionsYield
In di-isopropyl ether for 1.5h; Product distribution / selectivity; Inert atmosphere;99%
hydrogenchloride
7647-01-0

hydrogenchloride

rasagiline
136236-51-6

rasagiline

[14C]-Rasagiline hydrochloride
136236-50-5

[14C]-Rasagiline hydrochloride

Conditions
ConditionsYield
In tert-butyl methyl ether at 5 - 10℃; for 0.5h; Solvent; Acidic conditions;99%
methanesulfonic acid
75-75-2

methanesulfonic acid

rasagiline
136236-51-6

rasagiline

rasagiline mesylate
161735-79-1

rasagiline mesylate

Conditions
ConditionsYield
In isopropyl alcohol for 1h; Reflux;98%
In toluene; acetonitrile at 40 - 80℃; Product distribution / selectivity;86.2%
In isopropyl alcohol at 5 - 10℃; for 0.5h;83%
1-decanoic acid
334-48-5

1-decanoic acid

rasagiline
136236-51-6

rasagiline

rasagiline decanoate
1260684-11-4

rasagiline decanoate

Conditions
ConditionsYield
In di-isopropyl ether for 1.5h; Inert atmosphere;96%
cis-Octadecenoic acid
112-80-1

cis-Octadecenoic acid

rasagiline
136236-51-6

rasagiline

rasagiline oleate
1260684-14-7

rasagiline oleate

Conditions
ConditionsYield
In di-isopropyl ether for 1.5h; Product distribution / selectivity; Inert atmosphere;94%
oxalic acid
144-62-7

oxalic acid

rasagiline
136236-51-6

rasagiline

(R)-(+)-n-propargyl-1-aminoindane oxalate

(R)-(+)-n-propargyl-1-aminoindane oxalate

Conditions
ConditionsYield
In isopropyl alcohol93.1%
rasagiline
136236-51-6

rasagiline

(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide
694436-33-4

(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In isopropyl alcohol at 5 - 10℃; for 0.5h;90%
With hydrogen bromide at 25 - 65℃; for 0.5h; Product distribution / selectivity;
hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

rasagiline
136236-51-6

rasagiline

(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide
694436-33-4

(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine hydrobromide

Conditions
ConditionsYield
In isopropyl alcohol at 5 - 10℃; for 0.5h;90%
L-Tartaric acid
87-69-4

L-Tartaric acid

rasagiline
136236-51-6

rasagiline

(1R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine hemihydrate

(1R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine hemihydrate

Conditions
ConditionsYield
In isopropyl alcohol at 40℃; for 2.16667h;88%
In methanol; butanone for 1.16667h; Solvent; Time; Temperature; Reflux;72%
In isopropyl alcohol at 40℃; for 2h; Product distribution / selectivity;
naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

rasagiline
136236-51-6

rasagiline

di(rasagiline) naphthalene-1,5-disulfonate

di(rasagiline) naphthalene-1,5-disulfonate

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; Cooling with ice;86%
(S)-Mandelic acid
17199-29-0

(S)-Mandelic acid

rasagiline
136236-51-6

rasagiline

R-(+)-N-propargyl-1-aminoindane L-(+)-mandelate
1309125-23-2

R-(+)-N-propargyl-1-aminoindane L-(+)-mandelate

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; Heating; Cooling with ice;85%
In n-heptane; isopropyl alcohol
In ethyl acetate; isopropyl alcohol at 20℃; for 24h; Heating;
1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

rasagiline
136236-51-6

rasagiline

(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine palmitate
1260684-23-8

(1R)-2,3-dihydro-N-2-propynyl-1H-indane-1-amine palmitate

Conditions
ConditionsYield
In isopropyl alcohol at 5 - 10℃; for 0.5h;85%
In isopropyl alcohol at 5 - 10℃; for 0.5h;85%
D-Malic acid
636-61-3

D-Malic acid

rasagiline
136236-51-6

rasagiline

rasagiline (D)-malate
1377248-97-9

rasagiline (D)-malate

Conditions
ConditionsYield
In isopropyl alcohol Heating; Cooling with ice;84%
(1S)-10-camphorsulfonic acid
3144-16-9

(1S)-10-camphorsulfonic acid

rasagiline
136236-51-6

rasagiline

rasagiline (1S)-(+)-10-camphorsulfonate
1309125-24-3

rasagiline (1S)-(+)-10-camphorsulfonate

Conditions
ConditionsYield
In methanol at 20℃; for 1h;79%
In n-heptane; isopropyl alcohol

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