Products

Refine

Country

Business Type

Certificate

Display

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Dasatinib Synonyms: N-(2-chloro-6-Methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-Methyl-4-pyriMidinyl]aMino]-1,3-thiazole-5-carboxaMide;sprycel Dasatinib;NCGC00181129;Dasatinib (Dasatinib Monohydrate) Tablet;Dasatinib (anh

Dasatinib 99% Manufactuered in China best quality

Cas:302962-49-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Yangzhou Qinyuan Pharmatech Co.,Ltd

Dasatinib Cas no. 302962-49-8 Dasatinib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team

Dasatinib

Cas:302962-49-8

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Dasatinib

Cas:302962-49-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Dasatinib

Cas:302962-49-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to off-white powder off-white powder Assay 99%min

High purity Various Specifications Dasatinib CAS:302962-49-8

Cas:302962-49-8

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Sinoway Industrial Co., Ltd.

Sinoway's advantage: (1) ISO 9001:2008 certificated company (2) 28 years in pharmaceutical industry (3)China office of Fischer Chemicals AG (Switzerland) Appearance: white crystalline powder Package:according your requirement

GMP certified high price Dasatinib

Cas:302962-49-8

Min.Order:100 Gram

FOB Price: $100.0

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co. Ltd. is one of the most professional company in pharm/chmecial industry for more than 10 years. is located in Wuhan, Hubei province. We export to many countries and area with very competitive price, high quality, good service. E

Dasatinib high purity 99%

Cas:302962-49-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name Dasatinib Synonyms BMS 354825; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

Dasatinib/302962-49-8

Cas:302962-49-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Treatment 99%min Dasatinib Manufacturer 302962-49-8

Cas:302962-49-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White solid Storage:-20°C Freezer Package:1kg/foil bag; 1kg/t

High quality Dasatinib CAS 302962-49-8 with attractive price

Cas:302962-49-8

Min.Order:1 Kilogram

FOB Price: $1500.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Dasatinib 302962-49-8 GMP Manufacturer

Cas:302962-49-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an

Dasatinib

Cas:302962-49-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Dasatinib

Cas:302962-49-8

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Dasatinib

Cas:302962-49-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Dasatinib

Cas:302962-49-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Dasatinib CAS NO:302962-49-8 Grade:Medical scientific research and export Molecular formula:C22H28ClN7O3S Molecular weight:506.0208 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability

Dasatinib/ CAS:302962-49-8/Dasatinib raw material/ high-quality

Cas:302962-49-8

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM 302962-49-8 Dasatinib

Cas:302962-49-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Dasatinib

Cas:302962-49-8

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 302962-49-8 with competitive price

Cas:302962-49-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 302962-49-8 Dasatinib

Cas:302962-49-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Dasatinib/ LIDE PHARMA- Factory supply / Best price

Cas:302962-49-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Metabolism Drug; Carcino-Chemotherapeutic Drug Transportation:By sea or by air Port:Qingdao Port

Dasaitinib

Cas:302962-49-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

CML Treatment 99%min Dasatinib Manufacturer 302962-49-8

Cas:302962-49-8

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Room temperature Package:100g/bag,1kg/bag Application:API Transportation:Express/Sea/Air Port:Any port in china

High Purity APIs Dasatinib 99% Manufactuer

Cas:302962-49-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Dasatinib from Wuhan, Hubei, China. It is m

Dasatinib

Cas:302962-49-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

Top quality Dasatinib(302962-49-8) Synonyms:Sprycel;Spyrcel;N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide CAS No.: 302962-49-8 Formula:C22H26ClN7O2S Molecular Weigh

Top quality Dasatinib 99%

Cas:302962-49-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder Storage:keep in cool and dry place

Dasatinib 302962-49-8 cas Ready stock

Cas:302962-49-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Dasatinib CAS 302962-49-8 For research Use only

Cas:302962-49-8

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Dasatinib Tinib antitumor drugs

Cas:302962-49-8

Min.Order:1 Kilogram

FOB Price: $16.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
With tetrabutylammomium bromide In acetonitrile at 30 - 80℃;97%
In propan-1-ol at 115 - 120℃; Temperature;93%
With copper(l) chloride In N,N-dimethyl-formamide at 65℃; for 2h; Temperature; Reagent/catalyst;91.6%
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide
1245157-85-0

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
With potassium carbonate In methanol; water at 60 - 65℃; for 3h; Solvent; Reagent/catalyst;96.4%
Stage #1: N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide With water; sodium hydroxide at 50℃; for 2h;
Stage #2: With hydrogenchloride In water at 20 - 25℃; pH=4;
88.7%
Stage #1: N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide With water; sodium hydroxide at 50℃; for 2h;
Stage #2: With hydrogenchloride In water at 20 - 25℃; pH=4;
88.7%
C20H24ClN5O4S

C20H24ClN5O4S

acetamidine hydrochloride
124-42-5

acetamidine hydrochloride

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
With sodium methylate In methanol at 65℃; for 4h; Temperature; Cooling with ice;95.3%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2,4-dichloro-2-methylpyrimidine
1780-26-3

2,4-dichloro-2-methylpyrimidine

2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
302964-24-5

2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine With potassium phosphate; 1-butyl-3-methylimidazolium aminoethanic acid salt at 80℃; for 1.5h;
Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide at 20 - 80℃; for 2h; Reagent/catalyst;
92.27%
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine With potassium phosphate; 1-butyl-3-methylimidazolium aminoethanic acid salt In N,N-dimethyl acetamide at 80℃; for 2h;
Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide In N,N-dimethyl acetamide at 80℃; for 3h; Solvent;
89.31%
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine With copper(l) iodide; dimethylaminoacetic acid; O4P(3-)*O4P(3-)*3K(1+) In N,N-dimethyl-formamide at 20℃; for 0.666667h;
Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide at 120℃; for 6h; Inert atmosphere;
88.41%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-(6-bromo-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-formamide
1245157-51-0

2-(6-bromo-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-formamide

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In butan-1-ol for 7h; Solvent; Time; Reflux;87.9%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol for 5h; Product distribution / selectivity; Reflux;73.6%
2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol
127116-19-2

2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol

2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
302964-24-5

2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
In 1,4-dioxane at 75℃; for 3h; Concentration;83.2%
With potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl at 100 - 110℃; for 20h;
C29H30ClN7O3S
1245157-86-1

C29H30ClN7O3S

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Stage #1: C29H30ClN7O3S With water; sodium hydroxide at 50℃; for 2h;
Stage #2: With hydrogenchloride In water at 20 - 25℃; pH=4;
82.5%
Stage #1: C29H30ClN7O3S With water; sodium hydroxide at 50℃; for 2h;
Stage #2: With hydrogenchloride In water at 20 - 25℃; pH=4;
82.5%
C29H32ClN7O2S
1245157-70-3

C29H32ClN7O2S

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Stage #1: C29H32ClN7O2S With boron trichloride In dichloromethane at -15 - 20℃;
Stage #2: With water In dichloromethane Cooling with ice;
82.2%
With boron trichloride In dichloromethane at -15 - 20℃;82.2%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

(2-(6-chloro-2-methylpyrimidine-4-ylamino)-N-(2-chloro-6-methylpbenyl)thiazole-5-carboxamide)

(2-(6-chloro-2-methylpyrimidine-4-ylamino)-N-(2-chloro-6-methylpbenyl)thiazole-5-carboxamide)

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 65 - 100℃; for 1h; Inert atmosphere;82%
2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid
1245157-42-9

2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0 - 20℃; Product distribution / selectivity; Inert atmosphere;80.9%
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0 - 20℃; Reagent/catalyst; Inert atmosphere;80.9%
C24H30ClN7O2S2
1245157-78-1

C24H30ClN7O2S2

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Stage #1: C24H30ClN7O2S2 With boron trichloride In dichloromethane at -15 - 20℃;
Stage #2: With water In dichloromethane Cooling with ice;
80.7%
With boron trichloride In dichloromethane at -15 - 20℃;80.7%
C30H34ClN7O3S
1245157-72-5

C30H34ClN7O3S

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Stage #1: C30H34ClN7O3S With boron trichloride In dichloromethane at -15 - 20℃;
Stage #2: With water In dichloromethane Cooling with ice;
77.3%
With boron trichloride In dichloromethane at -15 - 20℃;77.3%
C26H34ClN7O3S
1245157-77-0

C26H34ClN7O3S

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Stage #1: C26H34ClN7O3S With boron trichloride In dichloromethane at -15 - 20℃;
Stage #2: With water In dichloromethane Cooling with ice;
72.5%
With boron trichloride In dichloromethane at -15 - 20℃;72.5%
C24H30ClN7O3S
1245157-75-8

C24H30ClN7O3S

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Stage #1: C24H30ClN7O3S With boron trichloride In dichloromethane at -15 - 20℃;
Stage #2: With water In dichloromethane Cooling with ice;
70.6%
With boron trichloride In dichloromethane at -15 - 20℃;70.6%
N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide
910297-51-7

N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide

2-bromoethanol
540-51-2

2-bromoethanol

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; for 16h;36%
methyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate
1245157-35-0

methyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;32%
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0 - 20℃; Reagent/catalyst; Inert atmosphere;32%
2-chloro-6-methylphenyl isocyanate
40398-01-4

2-chloro-6-methylphenyl isocyanate

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 - -75 °C
1.2: 86 percent / tetrahydrofuran; hexane / 2 h / -78 °C
2.1: NaH / dimethylformamide / 0.5 h
2.2: 95 percent / Bu4NI / dimethylformamide / 16 h / 20 °C
3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
3.2: 83 percent / tetrahydrofuran / 4 h / Heating
4.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C
5.1: i-Pr2NEt / dioxane / 12 h / Heating
View Scheme
Multi-step reaction with 5 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C
1.2: 86 percent / tetrahydrofuran; hexane / 2 h / -78 °C
2.1: NaH / dimethylformamide / 0.5 h / 20 °C
2.2: 95 percent / tetrabutylammonium iodide / dimethylformamide / 16 h / 20 °C
3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
3.2: 83 percent / tetrahydrofuran / 4 h / Heating
4.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C
5.1: diisopropylethylamine / dioxane / 12 h / Heating
View Scheme
2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
302964-11-0

2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: 95 percent / Bu4NI / dimethylformamide / 16 h / 20 °C
2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
2.2: 83 percent / tetrahydrofuran / 4 h / Heating
3.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C
4.1: i-Pr2NEt / dioxane / 12 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: NaH / dimethylformamide / 0.5 h / 20 °C
1.2: 95 percent / tetrabutylammonium iodide / dimethylformamide / 16 h / 20 °C
2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
2.2: 83 percent / tetrahydrofuran / 4 h / Heating
3.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C
4.1: diisopropylethylamine / dioxane / 12 h / Heating
View Scheme
N-(4-methoxybenzyl)-2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
834888-63-0

N-(4-methoxybenzyl)-2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
1.2: 83 percent / tetrahydrofuran / 4 h / Heating
2.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C
3.1: i-Pr2NEt / dioxane / 12 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
1.2: 83 percent / tetrahydrofuran / 4 h / Heating
2.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C
3.1: diisopropylethylamine / dioxane / 12 h / Heating
View Scheme
N-(4-methoxybenzyl)-2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
834888-64-1

N-(4-methoxybenzyl)-2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C
2: i-Pr2NEt / dioxane / 12 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C
2: diisopropylethylamine / dioxane / 12 h / Heating
View Scheme
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide n-butanolate

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide n-butanolate

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
In ethanol; water at 0 - 80℃; for 5h; Product distribution / selectivity;
dasatinib monohydrate
863127-77-9

dasatinib monohydrate

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
In propan-1-ol; water at 0 - 5℃; for 1h; Product distribution / selectivity; Heating / reflux;
In water; isopropyl alcohol at 0 - 5℃; for 1h; Product distribution / selectivity; Heating / reflux;
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide iso-propanolate

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide iso-propanolate

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide at 20 - 100℃;
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 8 h / Reflux
2: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: dichloromethane / 2.5 h / 30 °C
2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux
2.2: 0.17 h
2.3: 1 h / 10 - 15 °C
3.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 8 h / Reflux
2.1: water; lithium hydroxide / water / 3 h / 50 °C
2.2: 20 °C / pH 6 - 6.5
3.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
2,4-dichloro-2-methylpyrimidine
1780-26-3

2,4-dichloro-2-methylpyrimidine

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dichloromethane / 2.5 h / 30 °C
2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux
2.2: 0.17 h
2.3: 1 h / 10 - 15 °C
3.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: dichloromethane / 2.5 h / 30 °C
2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux
2.2: 0.17 h
2.3: 1 h / 10 - 15 °C
3.1: water; lithium hydroxide / water / 3 h / 50 °C
3.2: 20 °C / pH 6 - 6.5
4.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: dichloromethane / 2.5 h / 30 °C
2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux
2.2: 0.17 h
2.3: 1 h / 10 - 15 °C
3.1: sodium hydroxide; water / 20 °C
3.2: pH 6 - 6.5
4.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formyl chloride
1245158-43-3

2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formyl chloride

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 10 - 30℃; Product distribution / selectivity;
Stage #1: 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formyl chloride; 2-chloro-6-methylaniline In acetonitrile at 10 - 15℃;
Stage #2: With N-ethyl-N,N-diisopropylamine In acetonitrile at 30℃;
13.7 g
2-(6-(4-(2-benzoyloxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid
1245157-82-7

2-(6-(4-(2-benzoyloxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: sodium hydroxide; water / 2 h / 50 °C
2.2: 20 - 25 °C / pH 4
View Scheme
C22H23ClN6O3S
1245158-47-7

C22H23ClN6O3S

2-chloro-6-methylaniline
87-63-8

2-chloro-6-methylaniline

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C
2.1: sodium hydroxide; water / 2 h / 50 °C
2.2: 20 - 25 °C / pH 4
View Scheme
2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol
127116-19-2

2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux
1.2: 0.17 h
1.3: 1 h / 10 - 15 °C
2.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux
1.2: 0.17 h
1.3: 1 h / 10 - 15 °C
2.1: water; lithium hydroxide / water / 3 h / 50 °C
2.2: 20 °C / pH 6 - 6.5
3.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux
1.2: 0.17 h
1.3: 1 h / 10 - 15 °C
2.1: sodium hydroxide; water / 20 °C
2.2: pH 6 - 6.5
3.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
dasatanib
302962-49-8

dasatanib

dasatinib N-oxide

dasatinib N-oxide

Conditions
ConditionsYield
With dihydrogen peroxide In 1-methyl-pyrrolidin-2-one; water at 20℃; for 18h;100%
With hydrogenchloride; dihydrogen peroxide In acetonitrile at 90℃; for 7h; Temperature; Sealed tube;80%
With dihydrogen peroxide In 1-methyl-pyrrolidin-2-one at 40℃;
dasatanib
302962-49-8

dasatanib

N-(2-chloro-6-methylphenyl)-2-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-ylamino]-1,3-thiazole-5-carboxamide dihydrogen bromide

N-(2-chloro-6-methylphenyl)-2-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-ylamino]-1,3-thiazole-5-carboxamide dihydrogen bromide

Conditions
ConditionsYield
With hydrogen bromide In ethanol; water at 70℃;97.7%
4-Ethoxyphenol
622-62-8

4-Ethoxyphenol

dasatanib
302962-49-8

dasatanib

dasatinib 4-ethoxyphenol co-crystal

dasatinib 4-ethoxyphenol co-crystal

Conditions
ConditionsYield
In water at 50℃;97%
dasatanib
302962-49-8

dasatanib

dasatinib monohydrate
863127-77-9

dasatinib monohydrate

Conditions
ConditionsYield
With ethanol; water at 80℃; for 2h; Large scale;96.44%
With water In ethanol at 75 - 80℃;
With water In ethanol at 0 - 80℃; for 5h;
With water In methanol Solvent; Heating;21 g
Conditions
ConditionsYield
In methanol at 25 - 65℃; for 0.833333h; Time;95.6%
methanesulfonic acid
75-75-2

methanesulfonic acid

dasatanib
302962-49-8

dasatanib

N-(2-chloro-6-methylphenyl)-2-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-ylamino]-1,3-thiazole-5-carboxamide dimethanesulfonate salt

N-(2-chloro-6-methylphenyl)-2-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-ylamino]-1,3-thiazole-5-carboxamide dimethanesulfonate salt

Conditions
ConditionsYield
With hydrogen bromide In butanone at 60℃;93.7%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

dasatanib
302962-49-8

dasatanib

2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
881381-50-6

2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Conditions
ConditionsYield
With triethylamine; dmap In N,N-dimethyl-formamide at 20℃; for 1.5h;93.4%
cyclohexylsulfamic acid
100-88-9

cyclohexylsulfamic acid

dasatanib
302962-49-8

dasatanib

N-(2-chloro-6-methylphenyl)-2-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-ylamino]-1,3-thiazole-5-carboxamide monocyclamate salt

N-(2-chloro-6-methylphenyl)-2-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-ylamino]-1,3-thiazole-5-carboxamide monocyclamate salt

Conditions
ConditionsYield
In methanol at 70℃;93.4%
succinic acid anhydride
108-30-5

succinic acid anhydride

dasatanib
302962-49-8

dasatanib

4-(2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl) piperazin-1-yl)ethoxy)-4-oxobutanoic acid

4-(2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl) piperazin-1-yl)ethoxy)-4-oxobutanoic acid

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 48h; Schlenk technique;93%
With dmap In N,N-dimethyl-formamide at 50℃; for 18h; Inert atmosphere;90%
With triethylamine In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere;90%
lauric acid
143-07-7

lauric acid

dasatanib
302962-49-8

dasatanib

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl dodecanoate

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl dodecanoate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice;91%
copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

dasatanib
302962-49-8

dasatanib

C22H28ClCuN9O9S*NO3(1-)*H(1+)

C22H28ClCuN9O9S*NO3(1-)*H(1+)

Conditions
ConditionsYield
In methanol; dimethyl sulfoxide at 80℃; for 12h;91%
copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

dasatanib
302962-49-8

dasatanib

C22H28ClCuN9O9S*HNO3

C22H28ClCuN9O9S*HNO3

Conditions
ConditionsYield
In methanol; dimethyl sulfoxide at 80℃; for 12h; Solvent; Temperature;91%
formic acid
64-18-6

formic acid

dasatanib
302962-49-8

dasatanib

C23H26ClN7O3S

C23H26ClN7O3S

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 100℃; for 10h; Temperature;90.4%
1-decanoic acid
334-48-5

1-decanoic acid

dasatanib
302962-49-8

dasatanib

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl decanoate

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl decanoate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice;90.1%
Octanoic acid
124-07-2

Octanoic acid

dasatanib
302962-49-8

dasatanib

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl octanoate

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl octanoate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice;90%
carvacrol
499-75-2

carvacrol

dasatanib
302962-49-8

dasatanib

dasatinib carvacrol co-crystal

dasatinib carvacrol co-crystal

Conditions
ConditionsYield
In methanol at 50℃;90%
n-tetradecanoic acid
544-63-8

n-tetradecanoic acid

dasatanib
302962-49-8

dasatanib

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl tetradecanoate

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl tetradecanoate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice;88.6%
phthalimide
136918-14-4

phthalimide

dasatanib
302962-49-8

dasatanib

N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-(1,3-dioxoisoindol-2-yl)ethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-(1,3-dioxoisoindol-2-yl)ethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide

Conditions
ConditionsYield
With diisopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;88%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 0.166667h;87.8%
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

dasatanib
302962-49-8

dasatanib

N-(2-chloro-6-methylphenyl)-2-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-ylamino]-1,3-thiazole-5-carboxamide p-toluenesulfonate salt

N-(2-chloro-6-methylphenyl)-2-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-ylamino]-1,3-thiazole-5-carboxamide p-toluenesulfonate salt

Conditions
ConditionsYield
In water; isopropyl alcohol at 70℃; Solvent;87.4%
In ethanol at 65 - 70℃; for 4h;
In ethanol Heating / reflux;
1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

dasatanib
302962-49-8

dasatanib

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)pyrimidin-4-yl)piperazin-1-yl)ethyl palmitate

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)pyrimidin-4-yl)piperazin-1-yl)ethyl palmitate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice;86.5%
stearic acid
57-11-4

stearic acid

dasatanib
302962-49-8

dasatanib

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)pyrimidin-4-yl)piperazin-1-yl)ethyl stearate

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)pyrimidin-4-yl)piperazin-1-yl)ethyl stearate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 25℃; Inert atmosphere; Cooling with ice;86.3%
acetic acid
64-19-7

acetic acid

dasatanib
302962-49-8

dasatanib

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide
1245157-85-0

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice;86%
citric acid triethyl ester
77-93-0

citric acid triethyl ester

dasatanib
302962-49-8

dasatanib

C22H26ClN7O2S*C12H20O7

C22H26ClN7O2S*C12H20O7

Conditions
ConditionsYield
In methanol at 20℃; for 3h;86%
Arachidic acid
506-30-9

Arachidic acid

dasatanib
302962-49-8

dasatanib

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)pyrimidin-4-yl)piperazin-1-yl)ethyl icosanoate

2-(4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)pyrimidin-4-yl)piperazin-1-yl)ethyl icosanoate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 25℃; Inert atmosphere; Cooling with ice;85.3%
dasatanib
302962-49-8

dasatanib

3-bromodasatinib

3-bromodasatinib

Conditions
ConditionsYield
With hydrogen fluoride; antimony pentafluoride; sodium bromide at -20℃;84%

Downstream Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View