Product Name: Dasatinib Synonyms: N-(2-chloro-6-Methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-Methyl-4-pyriMidinyl]aMino]-1,3-thiazole-5-carboxaMide;sprycel Dasatinib;NCGC00181129;Dasatinib (Dasatinib Monohydrate) Tablet;Dasatinib (anh
Cas:302962-49-8
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryDasatinib Cas no. 302962-49-8 Dasatinib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:302962-49-8
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Items Standard Result Appearance White to off-white powder off-white powder Assay 99%min
Cas:302962-49-8
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquirySinoway's advantage: (1) ISO 9001:2008 certificated company (2) 28 years in pharmaceutical industry (3)China office of Fischer Chemicals AG (Switzerland) Appearance: white crystalline powder Package:according your requirement
Cas:302962-49-8
Min.Order:100 Gram
FOB Price: $100.0
Type:Trading Company
inquiryHubei Vanz Pharm Co. Ltd. is one of the most professional company in pharm/chmecial industry for more than 10 years. is located in Wuhan, Hubei province. We export to many countries and area with very competitive price, high quality, good service. E
Name Dasatinib Synonyms BMS 354825; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:302962-49-8
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White solid Storage:-20°C Freezer Package:1kg/foil bag; 1kg/t
Cas:302962-49-8
Min.Order:1 Kilogram
FOB Price: $1500.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:302962-49-8
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:302962-49-8
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:302962-49-8
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Dasatinib CAS NO:302962-49-8 Grade:Medical scientific research and export Molecular formula:C22H28ClN7O3S Molecular weight:506.0208 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability
Cas:302962-49-8
Min.Order:25 Kilogram
FOB Price: $2.0 / 3.0
Type:Other
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:302962-49-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:302962-49-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:302962-49-8
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:302962-49-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Metabolism Drug; Carcino-Chemotherapeutic Drug Transportation:By sea or by air Port:Qingdao Port
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:302962-49-8
Min.Order:10 Gram
Negotiable
Type:Other
inquiryAppearance:White powder Storage:Room temperature Package:100g/bag,1kg/bag Application:API Transportation:Express/Sea/Air Port:Any port in china
Cas:302962-49-8
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Dasatinib from Wuhan, Hubei, China. It is m
Top quality Dasatinib(302962-49-8) Synonyms:Sprycel;Spyrcel;N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide CAS No.: 302962-49-8 Formula:C22H26ClN7O2S Molecular Weigh
Cas:302962-49-8
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder Storage:keep in cool and dry place
Cas:302962-49-8
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:302962-49-8
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:302962-49-8
Min.Order:1 Kilogram
FOB Price: $16.0 / 20.0
Type:Trading Company
inquiry1-(2-hydroxyethyl)piperazine
2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
dasatanib
Conditions | Yield |
---|---|
With tetrabutylammomium bromide In acetonitrile at 30 - 80℃; | 97% |
In propan-1-ol at 115 - 120℃; Temperature; | 93% |
With copper(l) chloride In N,N-dimethyl-formamide at 65℃; for 2h; Temperature; Reagent/catalyst; | 91.6% |
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide
dasatanib
Conditions | Yield |
---|---|
With potassium carbonate In methanol; water at 60 - 65℃; for 3h; Solvent; Reagent/catalyst; | 96.4% |
Stage #1: N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide With water; sodium hydroxide at 50℃; for 2h; Stage #2: With hydrogenchloride In water at 20 - 25℃; pH=4; | 88.7% |
Stage #1: N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide With water; sodium hydroxide at 50℃; for 2h; Stage #2: With hydrogenchloride In water at 20 - 25℃; pH=4; | 88.7% |
Conditions | Yield |
---|---|
With sodium methylate In methanol at 65℃; for 4h; Temperature; Cooling with ice; | 95.3% |
1-(2-hydroxyethyl)piperazine
2,4-dichloro-2-methylpyrimidine
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
dasatanib
Conditions | Yield |
---|---|
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine With potassium phosphate; 1-butyl-3-methylimidazolium aminoethanic acid salt at 80℃; for 1.5h; Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide at 20 - 80℃; for 2h; Reagent/catalyst; | 92.27% |
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine With potassium phosphate; 1-butyl-3-methylimidazolium aminoethanic acid salt In N,N-dimethyl acetamide at 80℃; for 2h; Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide In N,N-dimethyl acetamide at 80℃; for 3h; Solvent; | 89.31% |
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine With copper(l) iodide; dimethylaminoacetic acid; O4P(3-)*O4P(3-)*3K(1+) In N,N-dimethyl-formamide at 20℃; for 0.666667h; Stage #2: 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide at 120℃; for 6h; Inert atmosphere; | 88.41% |
1-(2-hydroxyethyl)piperazine
2-(6-bromo-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-formamide
dasatanib
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In butan-1-ol for 7h; Solvent; Time; Reflux; | 87.9% |
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol for 5h; Product distribution / selectivity; Reflux; | 73.6% |
2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol
2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
dasatanib
Conditions | Yield |
---|---|
In 1,4-dioxane at 75℃; for 3h; Concentration; | 83.2% |
With potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl at 100 - 110℃; for 20h; |
C29H30ClN7O3S
dasatanib
Conditions | Yield |
---|---|
Stage #1: C29H30ClN7O3S With water; sodium hydroxide at 50℃; for 2h; Stage #2: With hydrogenchloride In water at 20 - 25℃; pH=4; | 82.5% |
Stage #1: C29H30ClN7O3S With water; sodium hydroxide at 50℃; for 2h; Stage #2: With hydrogenchloride In water at 20 - 25℃; pH=4; | 82.5% |
C29H32ClN7O2S
dasatanib
Conditions | Yield |
---|---|
Stage #1: C29H32ClN7O2S With boron trichloride In dichloromethane at -15 - 20℃; Stage #2: With water In dichloromethane Cooling with ice; | 82.2% |
With boron trichloride In dichloromethane at -15 - 20℃; | 82.2% |
1-(2-hydroxyethyl)piperazine
dasatanib
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one at 65 - 100℃; for 1h; Inert atmosphere; | 82% |
2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid
2-chloro-6-methylaniline
dasatanib
Conditions | Yield |
---|---|
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0 - 20℃; Product distribution / selectivity; Inert atmosphere; | 80.9% |
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0 - 20℃; Reagent/catalyst; Inert atmosphere; | 80.9% |
C24H30ClN7O2S2
dasatanib
Conditions | Yield |
---|---|
Stage #1: C24H30ClN7O2S2 With boron trichloride In dichloromethane at -15 - 20℃; Stage #2: With water In dichloromethane Cooling with ice; | 80.7% |
With boron trichloride In dichloromethane at -15 - 20℃; | 80.7% |
C30H34ClN7O3S
dasatanib
Conditions | Yield |
---|---|
Stage #1: C30H34ClN7O3S With boron trichloride In dichloromethane at -15 - 20℃; Stage #2: With water In dichloromethane Cooling with ice; | 77.3% |
With boron trichloride In dichloromethane at -15 - 20℃; | 77.3% |
C26H34ClN7O3S
dasatanib
Conditions | Yield |
---|---|
Stage #1: C26H34ClN7O3S With boron trichloride In dichloromethane at -15 - 20℃; Stage #2: With water In dichloromethane Cooling with ice; | 72.5% |
With boron trichloride In dichloromethane at -15 - 20℃; | 72.5% |
C24H30ClN7O3S
dasatanib
Conditions | Yield |
---|---|
Stage #1: C24H30ClN7O3S With boron trichloride In dichloromethane at -15 - 20℃; Stage #2: With water In dichloromethane Cooling with ice; | 70.6% |
With boron trichloride In dichloromethane at -15 - 20℃; | 70.6% |
N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin 4-yl)amino)thiazole-5-carboxamide
2-bromoethanol
dasatanib
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; for 16h; | 36% |
methyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate
2-chloro-6-methylaniline
dasatanib
Conditions | Yield |
---|---|
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 32% |
With O-phenyl phosphorodichloridate; triethylamine In dichloromethane at 0 - 20℃; Reagent/catalyst; Inert atmosphere; | 32% |
2-chloro-6-methylphenyl isocyanate
dasatanib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 - -75 °C 1.2: 86 percent / tetrahydrofuran; hexane / 2 h / -78 °C 2.1: NaH / dimethylformamide / 0.5 h 2.2: 95 percent / Bu4NI / dimethylformamide / 16 h / 20 °C 3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 3.2: 83 percent / tetrahydrofuran / 4 h / Heating 4.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C 5.1: i-Pr2NEt / dioxane / 12 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C 1.2: 86 percent / tetrahydrofuran; hexane / 2 h / -78 °C 2.1: NaH / dimethylformamide / 0.5 h / 20 °C 2.2: 95 percent / tetrabutylammonium iodide / dimethylformamide / 16 h / 20 °C 3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 3.2: 83 percent / tetrahydrofuran / 4 h / Heating 4.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C 5.1: diisopropylethylamine / dioxane / 12 h / Heating View Scheme |
2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
dasatanib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: 95 percent / Bu4NI / dimethylformamide / 16 h / 20 °C 2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 2.2: 83 percent / tetrahydrofuran / 4 h / Heating 3.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C 4.1: i-Pr2NEt / dioxane / 12 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1.1: NaH / dimethylformamide / 0.5 h / 20 °C 1.2: 95 percent / tetrabutylammonium iodide / dimethylformamide / 16 h / 20 °C 2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 2.2: 83 percent / tetrahydrofuran / 4 h / Heating 3.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C 4.1: diisopropylethylamine / dioxane / 12 h / Heating View Scheme |
N-(4-methoxybenzyl)-2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
dasatanib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 83 percent / tetrahydrofuran / 4 h / Heating 2.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C 3.1: i-Pr2NEt / dioxane / 12 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 83 percent / tetrahydrofuran / 4 h / Heating 2.1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C 3.1: diisopropylethylamine / dioxane / 12 h / Heating View Scheme |
N-(4-methoxybenzyl)-2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
dasatanib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C 2: i-Pr2NEt / dioxane / 12 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 99 percent / TFA; triflic acid / CH2Cl2 / 3 h / 20 °C 2: diisopropylethylamine / dioxane / 12 h / Heating View Scheme |
dasatanib
Conditions | Yield |
---|---|
In ethanol; water at 0 - 80℃; for 5h; Product distribution / selectivity; |
dasatinib monohydrate
dasatanib
Conditions | Yield |
---|---|
In propan-1-ol; water at 0 - 5℃; for 1h; Product distribution / selectivity; Heating / reflux; | |
In water; isopropyl alcohol at 0 - 5℃; for 1h; Product distribution / selectivity; Heating / reflux; |
dasatanib
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 20 - 100℃; |
1-(2-hydroxyethyl)piperazine
dasatanib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 8 h / Reflux 2: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: dichloromethane / 2.5 h / 30 °C 2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux 2.2: 0.17 h 2.3: 1 h / 10 - 15 °C 3.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 8 h / Reflux 2.1: water; lithium hydroxide / water / 3 h / 50 °C 2.2: 20 °C / pH 6 - 6.5 3.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
2,4-dichloro-2-methylpyrimidine
dasatanib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dichloromethane / 2.5 h / 30 °C 2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux 2.2: 0.17 h 2.3: 1 h / 10 - 15 °C 3.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: dichloromethane / 2.5 h / 30 °C 2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux 2.2: 0.17 h 2.3: 1 h / 10 - 15 °C 3.1: water; lithium hydroxide / water / 3 h / 50 °C 3.2: 20 °C / pH 6 - 6.5 4.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: dichloromethane / 2.5 h / 30 °C 2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux 2.2: 0.17 h 2.3: 1 h / 10 - 15 °C 3.1: sodium hydroxide; water / 20 °C 3.2: pH 6 - 6.5 4.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formyl chloride
2-chloro-6-methylaniline
dasatanib
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 10 - 30℃; Product distribution / selectivity; | |
Stage #1: 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formyl chloride; 2-chloro-6-methylaniline In acetonitrile at 10 - 15℃; Stage #2: With N-ethyl-N,N-diisopropylamine In acetonitrile at 30℃; | 13.7 g |
2-(6-(4-(2-benzoyloxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid
2-chloro-6-methylaniline
dasatanib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere 2.1: sodium hydroxide; water / 2 h / 50 °C 2.2: 20 - 25 °C / pH 4 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C 2.1: sodium hydroxide; water / 2 h / 50 °C 2.2: 20 - 25 °C / pH 4 View Scheme |
2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol
dasatanib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux 1.2: 0.17 h 1.3: 1 h / 10 - 15 °C 2.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux 1.2: 0.17 h 1.3: 1 h / 10 - 15 °C 2.1: water; lithium hydroxide / water / 3 h / 50 °C 2.2: 20 °C / pH 6 - 6.5 3.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / Reflux 1.2: 0.17 h 1.3: 1 h / 10 - 15 °C 2.1: sodium hydroxide; water / 20 °C 2.2: pH 6 - 6.5 3.1: triethylamine; O-phenyl phosphorodichloridate / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
dasatanib
Conditions | Yield |
---|---|
With dihydrogen peroxide In 1-methyl-pyrrolidin-2-one; water at 20℃; for 18h; | 100% |
With hydrogenchloride; dihydrogen peroxide In acetonitrile at 90℃; for 7h; Temperature; Sealed tube; | 80% |
With dihydrogen peroxide In 1-methyl-pyrrolidin-2-one at 40℃; |
dasatanib
Conditions | Yield |
---|---|
With hydrogen bromide In ethanol; water at 70℃; | 97.7% |
Conditions | Yield |
---|---|
In water at 50℃; | 97% |
dasatanib
dasatinib monohydrate
Conditions | Yield |
---|---|
With ethanol; water at 80℃; for 2h; Large scale; | 96.44% |
With water In ethanol at 75 - 80℃; | |
With water In ethanol at 0 - 80℃; for 5h; | |
With water In methanol Solvent; Heating; | 21 g |
dasatanib
Conditions | Yield |
---|---|
In methanol at 25 - 65℃; for 0.833333h; Time; | 95.6% |
methanesulfonic acid
dasatanib
Conditions | Yield |
---|---|
With hydrogen bromide In butanone at 60℃; | 93.7% |
tert-butyldimethylsilyl chloride
dasatanib
2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Conditions | Yield |
---|---|
With triethylamine; dmap In N,N-dimethyl-formamide at 20℃; for 1.5h; | 93.4% |
cyclohexylsulfamic acid
dasatanib
Conditions | Yield |
---|---|
In methanol at 70℃; | 93.4% |
succinic acid anhydride
dasatanib
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; for 48h; Schlenk technique; | 93% |
With dmap In N,N-dimethyl-formamide at 50℃; for 18h; Inert atmosphere; | 90% |
With triethylamine In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere; | 90% |
lauric acid
dasatanib
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice; | 91% |
Conditions | Yield |
---|---|
In methanol; dimethyl sulfoxide at 80℃; for 12h; | 91% |
Conditions | Yield |
---|---|
In methanol; dimethyl sulfoxide at 80℃; for 12h; Solvent; Temperature; | 91% |
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide at 100℃; for 10h; Temperature; | 90.4% |
1-decanoic acid
dasatanib
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice; | 90.1% |
Octanoic acid
dasatanib
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice; | 90% |
Conditions | Yield |
---|---|
In methanol at 50℃; | 90% |
n-tetradecanoic acid
dasatanib
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice; | 88.6% |
phthalimide
dasatanib
Conditions | Yield |
---|---|
With diisopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; | 88% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 0.166667h; | 87.8% |
toluene-4-sulfonic acid
dasatanib
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 70℃; Solvent; | 87.4% |
In ethanol at 65 - 70℃; for 4h; | |
In ethanol Heating / reflux; |
1-hexadecylcarboxylic acid
dasatanib
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice; | 86.5% |
stearic acid
dasatanib
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 25℃; Inert atmosphere; Cooling with ice; | 86.3% |
acetic acid
dasatanib
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; Cooling with ice; | 86% |
Conditions | Yield |
---|---|
In methanol at 20℃; for 3h; | 86% |
Arachidic acid
dasatanib
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 25℃; Inert atmosphere; Cooling with ice; | 85.3% |
dasatanib
Conditions | Yield |
---|---|
With hydrogen fluoride; antimony pentafluoride; sodium bromide at -20℃; | 84% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View